Drug & supplement interaction

Hydrazine Sulfate + Isoniazid, Pyrazinamide, Rifampin

Isoniazid, Pyrazinamide, Rifampin brand name: Rifater.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Hydrazine Sulfate has a moderate interaction with Isoniazid, Pyrazinamide, Rifampin. Theoretically, concurrent use of isoniazid and hydrazine sulfate might increase the risk for liver damage.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Hydrazine Sulfate and Isoniazid, Pyrazinamide, Rifampin

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ISONIAZID

Theoretically, concurrent use of isoniazid and hydrazine sulfate might increase the risk for liver damage.
Hydrazine sulfate is a metabolite of isoniazid. Animal research shows that hydrazine sulfate might be responsible for isoniazid-induced hepatotoxicity.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Rifater is a combination of three tuberculosis medicines, and the one that matters here is isoniazid. Interestingly, when your body breaks down isoniazid, one of the leftover byproducts is hydrazine, the same kind of compound found in hydrazine sulfate. Animal studies suggest this byproduct may be part of what makes isoniazid hard on the liver.

So the worry is that adding a hydrazine sulfate supplement could stack onto that risk and increase the chance of liver injury, such as yellowing skin or eyes, dark urine, nausea, belly pain, or unusual fatigue. To be honest, this is a theoretical concern from lab and animal work, not from strong human studies. Still, hydrazine sulfate is risky on its own and isn't recommended. Please check with your doctor or pharmacist before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Sarich TC, Adams SP, Petricca G, Wright JM. Inhibition of isoniazid-induced hepatotoxicity in rabbits by pretreatment with an amidase inhibitor. J Pharmacol Exp Ther 1999;289:695-702. DOI

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Hydrazine Sulfate Also Interacts With Other Medications

Hydrazine Sulfate has 97 moderate known drug interactions in our database — the Isoniazid, Pyrazinamide, Rifampin one above is one of them. If you take anything else, check it against the full list below.

Moderate 97 No known interaction 2,733 (incl. Isoniazid, Pyrazinamide, Rifampin)
Taking anything else?

Check Another of Your Medications Against Hydrazine Sulfate

Covers the 2,830 medications we’ve checked against Hydrazine Sulfate. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Isoniazid, Pyrazinamide, Rifampin

This page covers Hydrazine Sulfate only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Isoniazid, Pyrazinamide, Rifampin page lists 137 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Apple (major), Asarabacca (major), Beer (major) and Grapefruit (major).

By severity: 8 major · 109 moderate · 20 minor.

From our pharmacist’s overview on the Isoniazid, Pyrazinamide, Rifampin page

“Rifater combines isoniazid, pyrazinamide, and rifampin for tuberculosis, a regimen that runs for months and already works the liver hard, so this list warrants genuine care rather than a quick skim. Of the 137 supplements and herbs on file, eight rate major, and the largest single group, 38 ingredients, adds extra liver strain on top o…”

Reviewed by 2 · Jul 18, 2026

Open the Isoniazid, Pyrazinamide, Rifampin interaction page

How much people look this up

Where Hydrazine Sulfate and Isoniazid, Pyrazinamide, Rifampin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hydrazine Sulfate
Steady interest

#1,315 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Isoniazid, Pyrazinamide, Rifampin
Top 10%

#161 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Hydrazine Sulfate

What is Hydrazine Sulfate?

  • Cancer-related weight loss (cachexia)
  • Cancer treatment (unproven)
  • Appetite stimulation
  • Improving quality of life in advanced illness

Hydrazine sulfate is a synthetic industrial chemical that was promoted as an alternative cancer treatment, but well-designed clinical trials found it does not help people with cancer live longer or feel better. It carries real risks, including serious nerve and liver toxicity, and is not approved or recommended for any medical use. Talk with your doctor or pharmacist before considering it.

Read the full Hydrazine Sulfate monograph & all interactions
Keep checking

Other Drugs & Hydrazine Sulfate

Browse every other medication we’ve checked against Hydrazine Sulfate — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
97Moderate
0Minor
2,732No known interaction
97 Moderate 2,732 No interaction
Moderate

97 interactions

Showing 60 of 97 moderate interactions — see all 97 on the Hydrazine Sulfate page.

No interaction 2,732 drugs checked — show the list

We also checked Hydrazine Sulfate against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,732 medications checked with no known interaction — see the full Hydrazine Sulfate list.

See the full Hydrazine Sulfate interactions page
See every supplement checked against Isoniazid, Pyrazinamide, Rifampin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Hydrazine Sulfate monograph › Uses, safety, and every drug interaction in one place Isoniazid, Pyrazinamide, Rifampin supplement interactions › Every supplement checked against Isoniazid, Pyrazinamide, Rifampin, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Hydrazine Sulfate and Isoniazid, Pyrazinamide, Rifampin Together: Common Questions

Can you take Hydrazine Sulfate with Isoniazid, Pyrazinamide, Rifampin?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Hydrazine Sulfate and Isoniazid, Pyrazinamide, Rifampin interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.