Medication interaction hub

What Supplements Interact with Isoniazid, Pyrazinamide, Rifampin?

Isoniazid, Pyrazinamide, Rifampin brand name: Rifater. Every interaction below applies to the brands too.

137 Interactions 8 Major 109 Moderate 20 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Isoniazid, Pyrazinamide, Rifampin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Isoniazid, Pyrazinamide, Rifampin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Rifater combines isoniazid, pyrazinamide, and rifampin for tuberculosis, a regimen that runs for months and already works the liver hard, so this list warrants genuine care rather than a quick skim. Of the 137 supplements and herbs on file, eight rate major, and the largest single group, 38 ingredients, adds extra liver strain on top of drugs known for exactly that. Alcohol in any form belongs among those major entries, and it is the first one I would rule out.

The other major theme is absorption. Everyday juices, apple and grapefruit among them, block a gut transporter called OATP that helps oral drugs reach the bloodstream, and human studies confirm the effect, so keep them well apart from each dose. Most of the 109 moderate entries either raise sun sensitivity or shift how these drugs are broken down, and only 20 rate minor.

— , Clinical Pharmacist · July 18, 2026

Major 8 Moderate 109 Minor 20 No known interaction 1,315

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Isoniazid, Pyrazinamide, Rifampin: Top Interactions at a Glance

The Isoniazid, Pyrazinamide, Rifampin supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 137 interacting ingredients — plus 1,315 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Isoniazid, Pyrazinamide, Rifampin Combinations Today

The Isoniazid, Pyrazinamide, Rifampin + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Major Likelihood Likely Apple + Isoniazid, Pyrazinamide, Rifampini

Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.

Read the full interaction Major Likelihood Likely Sweet Orange + Isoniazid, Pyrazinamide, Rifampini

Consuming sweet orange juice can decrease oral absorption of OATP substrates.

Read the full interaction Moderate Likelihood Possible Black Cohosh + Isoniazid, Pyrazinamide, Rifampini

Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.

Read the full interaction Moderate Likelihood Possible Kratom + Isoniazid, Pyrazinamide, Rifampini

CYP3A4 inhibitors might increase the concentrations and clinical effects of kratom's primary active alkaloid mitragynine.

Read the full interaction Major Likelihood Likely Grapefruit + Isoniazid, Pyrazinamide, Rifampini

Grapefruit juice can decrease levels of drugs that are substrates of OATP.

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Isoniazid, Pyrazinamide, Rifampini

Siberian cocklebur can adversely affect the kidney.

Read the full interaction
The complete list

Every Supplement Checked Against Isoniazid, Pyrazinamide, Rifampin

All 1,452 ingredients in our database, ranked by severity — 137 with a Isoniazid, Pyrazinamide, Rifampin interaction on file and 1,315 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Isoniazid, Pyrazinamide, Rifampin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Apple with Isoniazid, Pyrazinamide, Rifampin?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.

Full Apple + Isoniazid, Pyrazinamide, Rifampin answer

Can you take Sweet Orange with Isoniazid, Pyrazinamide, Rifampin?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Consuming sweet orange juice can decrease oral absorption of OATP substrates.

Full Sweet Orange + Isoniazid, Pyrazinamide, Rifampin answer

Can you take Black Cohosh with Isoniazid, Pyrazinamide, Rifampin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.

Full Black Cohosh + Isoniazid, Pyrazinamide, Rifampin answer

Can you take Kratom with Isoniazid, Pyrazinamide, Rifampin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. CYP3A4 inhibitors might increase the concentrations and clinical effects of kratom's primary active alkaloid mitragynine.

Full Kratom + Isoniazid, Pyrazinamide, Rifampin answer

Can you take Black Psyllium with Isoniazid, Pyrazinamide, Rifampin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Isoniazid, Pyrazinamide, Rifampin answer

Can you take Blond Psyllium with Isoniazid, Pyrazinamide, Rifampin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Isoniazid, Pyrazinamide, Rifampin answer

Can you take Caffeine with Isoniazid, Pyrazinamide, Rifampin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Full Caffeine + Isoniazid, Pyrazinamide, Rifampin answer

Can you take Caraway with Isoniazid, Pyrazinamide, Rifampin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, caraway might increase the effects and adverse effects of isoniazid.

Full Caraway + Isoniazid, Pyrazinamide, Rifampin answer

Can you take Carob with Isoniazid, Pyrazinamide, Rifampin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Isoniazid, Pyrazinamide, Rifampin answer

Can you take Celery with Isoniazid, Pyrazinamide, Rifampin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, celery might increase the risk of photosensitivity reactions when taken with photosensitizing drugs.

Full Celery + Isoniazid, Pyrazinamide, Rifampin answer

Can you take Eleuthero with Isoniazid, Pyrazinamide, Rifampin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, eleuthero might decrease levels of drugs metabolized by OATP.

Full Eleuthero + Isoniazid, Pyrazinamide, Rifampin answer

Can you take Guarana with Isoniazid, Pyrazinamide, Rifampin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Full Guarana + Isoniazid, Pyrazinamide, Rifampin answer

Can you take Karaya Gum with Isoniazid, Pyrazinamide, Rifampin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Isoniazid, Pyrazinamide, Rifampin answer

Can you take Marshmallow with Isoniazid, Pyrazinamide, Rifampin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Isoniazid, Pyrazinamide, Rifampin answer

Can you take Milk Thistle with Isoniazid, Pyrazinamide, Rifampin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Milk thistle may inhibit one form of OATP, OATP-B1, which could reduce the bioavailability and clinical effects of OATP-B1 substrates.

Full Milk Thistle + Isoniazid, Pyrazinamide, Rifampin answer

Can you take Passion Flower with Isoniazid, Pyrazinamide, Rifampin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.

Full Passion Flower + Isoniazid, Pyrazinamide, Rifampin answer

Can you take Puravive with Isoniazid, Pyrazinamide, Rifampin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Puravive contains quercetin.

Full Puravive + Isoniazid, Pyrazinamide, Rifampin answer

Can you take Xanthan Gum with Isoniazid, Pyrazinamide, Rifampin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Isoniazid, Pyrazinamide, Rifampin answer

Can you take Yerba Mate with Isoniazid, Pyrazinamide, Rifampin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of CYP1A2 inhibitors and yerba mate might increase levels and adverse effects of the caffeine in yerba mate.

Full Yerba Mate + Isoniazid, Pyrazinamide, Rifampin answer

Can you take Asian Water Plantain with Isoniazid, Pyrazinamide, Rifampin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Studies on animals have shown that Asian water plantain extract, which contains triterpenoids, is generally safe at doses up to 1440 mg/kg o...

Full Asian Water Plantain + Isoniazid, Pyrazinamide, Rifampin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Isoniazid, Pyrazinamide, Rifampin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Isoniazid, Pyrazinamide, Rifampin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Isoniazid, Pyrazinamide, Rifampin sits in 17 interaction categories. Open any one to see what the group means:

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Isoniazid, Pyrazinamide, Rifampin through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Isoniazid, Pyrazinamide, Rifampin through this category.

Cytochrome P450 3A4 (Cyp3A4) Inducers 19 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

19 of the supplement ingredients on this page reach Isoniazid, Pyrazinamide, Rifampin through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Isoniazid, Pyrazinamide, Rifampin through this category.

Organic Anion-Transporting Polypeptide Substrates (Oatp) 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Isoniazid, Pyrazinamide, Rifampin through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Isoniazid, Pyrazinamide, Rifampin through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Isoniazid, Pyrazinamide, Rifampin through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Isoniazid, Pyrazinamide, Rifampin through this category.

Rifampin (Rifadin) 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Isoniazid, Pyrazinamide, Rifampin through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Isoniazid, Pyrazinamide, Rifampin through this category.

Cytochrome P450 2C9 (Cyp2C9) Inhibitors 4 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

4 of the supplement ingredients on this page reach Isoniazid, Pyrazinamide, Rifampin through this category.

Cytochrome P450 2C9 (Cyp2C9) Inducers 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Isoniazid, Pyrazinamide, Rifampin through this category.

Isoniazid 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Isoniazid, Pyrazinamide, Rifampin through this category.

Cytochrome P450 2C19 (Cyp2C19) Inducers 2 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

2 of the supplement ingredients on this page reach Isoniazid, Pyrazinamide, Rifampin through this category.

Cytochrome P450 2C19 (Cyp2C19) Inhibitors 2 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

2 of the supplement ingredients on this page reach Isoniazid, Pyrazinamide, Rifampin through this category.

Cytochrome P450 1A2 (Cyp1A2) Inducers 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Isoniazid, Pyrazinamide, Rifampin through this category.

Pyrazinamide 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Isoniazid, Pyrazinamide, Rifampin through this category.

Related: does Isoniazid, Pyrazinamide, Rifampin deplete any nutrients?

Isoniazid, Pyrazinamide, Rifampin has 5 reported nutrient associations in the research literature — see the Isoniazid, Pyrazinamide, Rifampin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Isoniazid, Pyrazinamide, Rifampin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Isoniazid, Pyrazinamide, Rifampin.

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Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Pharmacist Counseling Corner

Isoniazid, Pyrazinamide, Rifampin & Supplements: Common Questions

What supplements interact with Isoniazid, Pyrazinamide, Rifampin?
More than you might expect — 137 in total, though they are far from equal: 8 are rated major, 109 moderate, and 20 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Apple, Grapefruit, Siberian Cocklebur.
Which Isoniazid, Pyrazinamide, Rifampin supplement interactions are the most serious?
The 8 major-rated combinations — led by Apple, Grapefruit, Siberian Cocklebur, Sweet Orange and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Isoniazid, Pyrazinamide, Rifampin?
Usually yes — most people on Isoniazid, Pyrazinamide, Rifampin can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Rifater have the same supplement interactions as Isoniazid, Pyrazinamide, Rifampin?
Yes — Rifater all contain Isoniazid, Pyrazinamide, Rifampin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Isoniazid, Pyrazinamide, Rifampin deplete any vitamins or nutrients?
It might — Isoniazid, Pyrazinamide, Rifampin has 5 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Isoniazid, Pyrazinamide, Rifampin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Isoniazid, Pyrazinamide, Rifampin and my other medications?
This page covers Isoniazid, Pyrazinamide, Rifampin against supplements and herbal ingredients. Checking Isoniazid, Pyrazinamide, Rifampin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.