Herb & supplement monograph

Hemp Agrimony Drug Interactions, Uses, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Hemp Agrimony interacts with medications. The heart of this page is the interaction list — every drug Hemp Agrimony is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Hemp Agrimony is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

Check Hemp Agrimony against your medication

Add one medication
Hemp Agrimony
+
Start typing any prescription or over-the-counter drug name.
Reviewed by licensed pharmacists Sourced from Natural Medicines
On this page

Hemp Agrimony Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Hemp Agrimony drug interaction appears low for most people, though the liver concern behind these interactions deserves to be taken seriously. None of the listed interactions are rated major, and all of them rest on lab-based or theoretical evidence rather than documented problems in people.

Interactions deserving the most attention

Hemp agrimony naturally contains pyrrolizidine alkaloids, compounds that can harm the liver, and this single issue drives its entire interaction profile. The combinations we would watch most closely are with hepatotoxic drugs, meaning medications that can also stress the liver, such as acetaminophen, methotrexate, amiodarone, or isoniazid, since the effects could add up. Certain medicines, including carbamazepine, phenytoin, phenobarbital, and rifampin, may also speed up how the body converts these plant compounds into their more toxic forms.

What the rest of the list means

A list of hundreds of medications sounds alarming, but nearly every entry traces back to the same two theoretical liver concerns. These are predictions based on the plant's known compounds and how the body processes them, not on reported harm in people taking these combinations, so most pairings have never been shown to cause an actual problem.

Check your medications against Hemp Agrimony

Based on HelloPharmacist’s Hemp Agrimony interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Hemp Agrimony

440 medications have a known interaction with Hemp Agrimony, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
6-mercaptopurinePurinethol› Abacavir Sulfate, Dolutegravir, LamivudineTriumeq› Abacavir, LamivudineEpzicom› Abiraterone› Abiraterone AcetateYonsa, Zytiga› AcarboseGlucobay, Prandase, Precose› AcebutololRhotral, Sectral› AcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength› Acetaminophen, AspirinGemnisyn› Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine› Acetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu› Acetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more› Acetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more› Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine› Acetaminophen, Butalbital, CodeineBancap w/ Codeine› Acetaminophen, Butalbital, Codeine PhosphatePhrenilin #3› Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound› Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more› Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3› Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS› Acetaminophen, Caffeine, IsomethepteneMigralam› Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual› Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief› Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex› Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu› Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu› Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief› Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength› Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG› Acetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid›
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Hemp Agrimony combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Hemp Agrimony affects

Every type of medication (drug category) Hemp Agrimony is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 2 drug categories Hemp Agrimony interacts with
Cytochrome P450 3a4 (cyp3a4) InducersHepatotoxic Drugs
Cytochrome P450 3A4 (Cyp3A4) Inducers

Hemp agrimony contains hepatotoxic pyrrolizidine alkaloids (PA) which are substrates of cytochrome P450 3A4 (CYP3A4). Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites. Some drugs that induce CYP3A4 include carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, rifabutin (Mycobutin), and others.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Hemp agrimony contains hepatotoxic pyrrolizidine alkaloids (PA). Theoretically, using hemp agrimony with hepatotoxic drugs might have additive adverse effects on the liver. Some drugs that can adversely affect the liver include acetaminophen (Tylenol and others), amiodarone (Cordarone), carbamazepine (Tegretol), isoniazid (INH), methotrexate (Rheumatrex), methyldopa (Aldomet), fluconazole (Diflucan), itraconazole (Sporanox), erythromycin (Erythrocin, Ilosone, others), phenytoin (Dilantin), lovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor), and many others.

Likelihood Possible Evidence D
Monograph

Hemp Agrimony: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Hemp agrimony is a traditional European herb that has been used for digestion, colds, and as a general tonic, but there is very little reliable human research to support these uses. More importantly, the plant can contain pyrrolizidine alkaloids that may harm the liver, so most experts do not recommend taking it internally. Talk with your pharmacist or doctor before using any product that contains hemp agrimony.

Hemp Agrimony
Scientific name
Eupatorium cannabinum
Family
Asteraceae
Part used
Aerial parts (leaves, flowers, stems) and roots
Common forms
Tea, tincture, dried herb, liquid extract
People commonly use it for
  • Digestive complaints
  • Cold and flu symptoms
  • Respiratory conditions
  • Mild fever
  • Traditional 'tonic' or detox use

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallBest avoided

It may contain liver-toxic pyrrolizidine alkaloids, so internal use is generally not recommended.

PregnancyLikely Unsafe

When used orally. Hemp agrimony preparations, containing hepatotoxic pyrrolizidine alkaloid (PA) constituents, might be teratogenic and hepatotoxic. T...

Read the full pregnancy detail
BreastfeedingLikely Unsafe

When used orally. Hepatotoxic pyrrolizidine alkaloid (PA) constituents in hemp agrimony are excreted in milk. There is insufficient reliable informati...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Hemp agrimony (Eupatorium cannabinum) is a tall flowering plant in the daisy or aster family (Asteraceae). It has hairy, deeply divided leaves and clusters of small pinkish-purple flowers. It grows widely across Europe and parts of Asia, often in damp places like riverbanks, ditches, and marshy ground.

Despite its name, hemp agrimony is not related to marijuana (Cannabis sativa) and does not contain THC. The name comes from its leaves, which look a bit like those of the hemp plant.

For centuries it has been used in traditional European herbal medicine, usually as a tea or tincture, for digestive troubles, colds, and as a general 'cleansing' tonic. Today it is much less commonly used, in part because of concerns about its safety.

Uses & effectiveness

People have traditionally used hemp agrimony for a range of complaints, including digestive upset, colds and flu, fevers, and breathing problems such as coughs. Some folk traditions also used it as a diuretic (to increase urine) or as a so-called liver or blood 'tonic.'

The scientific evidence for these uses is very weak. Most of what we know comes from traditional use, laboratory tests, and a small amount of animal research. There are no strong, well-designed human studies showing that hemp agrimony reliably treats any health condition.

Because the evidence is so limited, hemp agrimony should not be relied on in place of proven treatments. If you have ongoing symptoms, it is best to see a healthcare provider.

How it works

Hemp agrimony contains a mix of natural compounds, including flavonoids, sesquiterpene lactones, essential oils, and tannins. Laboratory studies suggest some of these compounds may have antioxidant or immune-related effects, but this work is early and has not been confirmed in people.

The plant also contains pyrrolizidine alkaloids (PAs). These are the compounds that raise the most safety concern, because certain PAs are known to damage the liver and may be cancer-causing over time.

Overall, the proposed mechanisms are based mostly on test-tube and animal research. They do not prove that hemp agrimony works as a medicine in humans.

Safety & precautions

The main safety concern with hemp agrimony is its possible content of pyrrolizidine alkaloids, which can be toxic to the liver and may build up with repeated use. For this reason, many experts and herbal references advise against taking it by mouth.

People with liver disease, a history of liver problems, or anyone who drinks heavily should be especially cautious and should avoid it. Because hemp agrimony is in the daisy family, people allergic to ragweed, marigolds, chrysanthemums, or related plants may also react to it.

Pregnancy and breastfeeding: Avoid hemp agrimony if you are pregnant or breastfeeding. There is no reliable safety information, and the potential for liver-toxic compounds makes the risk too high. As a general rule, do not give it to children either.

Always tell your pharmacist or doctor about any herbal product you are taking or thinking about taking.

Side effects

Because hemp agrimony is not well studied in people, its full side effect profile is not known. Reported or possible effects include nausea, stomach upset, and allergic skin reactions, especially in people sensitive to plants in the daisy family.

The most serious concern is liver damage from pyrrolizidine alkaloids. This can develop slowly and without obvious early warning signs. Stop using the herb and seek medical care if you notice yellowing of the skin or eyes, dark urine, belly pain, unusual tiredness, or loss of appetite.

Hemp Agrimony: Reported Adverse Effects

Documented safety reports on Hemp Agrimony from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Reports by condition
Diarrhea Hepatic

Orally, the major concern with hemp agrimony preparations is the hepatotoxic pyrrolizidine alkaloid (PA) content. Chronic exposure to other plants containing hepatotoxic PA constituents is associated with veno-occlusive disease. Subacute veno-occlusive disease causes vague symptoms with persistent liver enlargement. Symptoms of acute veno-occlusive disease include colicky epigastrium pain, vomiting and diarrhea, and ascites formation within several days. Enlargement and induration of the liver occurs within a few weeks. Dietary supplements sold in the US are not required to disclose the amount of PAs they contain; therefore, all oral preparations containing hemp agrimony should be considered potentially unsafe.

  1. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46.
  2. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  3. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
  4. Klepser TB, Klepser ME. Unsafe and potentially safe herbal therapies. Am J Health Syst Pharm 1999;56:125-38.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no established safe or standardized dose for hemp agrimony. Because of concerns about liver-toxic compounds, most reliable sources do not recommend taking it internally at all.

If a product containing hemp agrimony is available, do not assume any amount is proven safe. Follow the product label, and check with a pharmacist or doctor before using it. When possible, choose better-studied alternatives for whatever condition you are trying to treat.

Pregnancy & Breastfeeding

Hemp Agrimony & Pregnancy

Likely Unsafe

When used orally. Hemp agrimony preparations, containing hepatotoxic pyrrolizidine alkaloid (PA) constituents, might be teratogenic and hepatotoxic. There is insufficient reliable information available about the safety of using hemp agrimony products that do not contain hepatotoxic PAs during pregnancy.

  1. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46.
  2. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.

Hemp Agrimony & Breastfeeding

Likely Unsafe

When used orally. Hepatotoxic pyrrolizidine alkaloid (PA) constituents in hemp agrimony are excreted in milk. There is insufficient reliable information available about the safety of using hemp agrimony products that do not contain hepatotoxic PAs during lactation.

  1. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46.
  2. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 5 references that drive our Hemp Agrimony monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Klepser TB, Klepser ME. Unsafe and potentially safe herbal therapies. Am J Health Syst Pharm 1999;56:125-38. PubMed
  2. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
  3. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  4. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  5. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Hemp Agrimony

1 brand in our database make a supplement containing Hemp Agrimony.

Product directory

Supplement products with Hemp Agrimony

3 products in our database contain Hemp Agrimony. Open any to see its full ingredient list and every drug interaction we check.

Pharmacist Counseling Corner

Hemp Agrimony: Common Questions

Does Hemp Agrimony interact with prescription medications?
Yes. We list 440 medications with a known interaction with Hemp Agrimony. Use the checker above to see how Hemp Agrimony interacts with a specific drug.
How are Hemp Agrimony interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Hemp Agrimony with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Hemp Agrimony interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
Is Hemp Agrimony the same as marijuana or hemp?
No. Hemp Agrimony is a different plant in the daisy family and does not contain THC or CBD. It only got its name because its leaves look similar to hemp leaves.
Is Hemp Agrimony safe to take?
Internal use is generally not recommended because the plant may contain pyrrolizidine alkaloids that can harm the liver. Talk with your pharmacist or doctor before using any product that contains it.
Can I use Hemp Agrimony for a cold or upset stomach?
It has been used this way traditionally, but there is no strong evidence it works, and the possible liver risk usually outweighs any benefit. Proven remedies are a safer choice.
Can I take Hemp Agrimony while pregnant or breastfeeding?
No. It should be avoided during pregnancy and breastfeeding because of possible liver-toxic compounds and a lack of safety data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Keep exploring

Products that contain Hemp Agrimony

A rotating sample of real supplements in our database that list Hemp Agrimony — open any to see its full ingredients and every drug interaction we check.

Where next
Supplement interaction checkerCheck any supplement or product against your medications Drug–drug interactionsCheck two or more of your medications against each other Browse medications A–ZEvery drug we’ve checked against herbs & supplements NDC & pricing lookupFind a drug’s NDCs, packaging and costs Ask a pharmacistFree, personal answer from our licensed team

Have a question about Hemp Agrimony?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist