Herb & supplement monograph

Testolone Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Testolone interacts with medications. The heart of this page is the interaction list — every drug Testolone is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Testolone is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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On this page

Testolone Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the risk of a clinically significant Testolone drug interaction is moderate, and nearly all of that risk comes down to one shared concern: added strain on the liver. Every interaction on the list is rated moderate, and all of them trace back to Testolone's possible effects on the liver rather than to many separate problems.

Interactions deserving the most attention

The combinations that deserve the most attention involve hepatotoxic drugs, meaning medications that can themselves stress or injure the liver. This concern is not just theoretical. Liver injury was reported in a man using products containing Testolone, and elevated liver enzyme levels were commonly seen in a human dose study of the compound. Pairing it with another medication that taxes the liver could add to that burden.

What the rest of the list means

A long list of interacting medications can look alarming, but here it reflects a single mechanism applied across many drugs, not hundreds of separate proven dangers. The additive liver effect remains possible rather than well established in people, so not every combination will cause harm. Still, the human reports of liver enzyme changes mean we would not dismiss the concern either.

Check your medications against Testolone

Based on HelloPharmacist’s Testolone interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Testolone

372 medications have a known interaction with Testolone, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Testolone using our pharmacist-reviewed interaction data.

AI summaries are generated from our Testolone interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Testolone combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Testolone affects

Every type of medication (drug category) Testolone is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Testolone interacts with

Hepatotoxic Drugs

Theoretically, concomitant use might have additive hepatotoxic effects.
In a case report, a 52-year-old male was diagnosed with liver injury thought to be related to the use of products containing testolone. Also, elevated liver enzymes were commonly reported in a dose escalation study of testolone.

Likelihood Possible Evidence B

Monograph

Testolone: Uses, Safety & Side Effects

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Reviewed July 2026 ·

The bottom line

Testolone (RAD-140) is a synthetic experimental drug called a selective androgen receptor modulator (SARM), not a dietary supplement or herb, and it is not approved or proven safe for human use. It is illegally sold for muscle building, has been linked to serious harms including liver injury, and is banned in sports — it should not be taken outside of supervised clinical research.

Part used: Synthetic compound (not a plant); supplied as a chemical powder or liquid
Common forms: Capsules, tablets, liquids, and powders sold as 'research chemicals'

People commonly use it for

Muscle building
Athletic performance and bodybuilding
Strength gains
Body recomposition (fat loss with muscle gain)

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance

OverallBest avoided

Testolone is an unapproved experimental drug with reported serious risks and should not be used.

PregnancyPossibly Unsafe

When used orally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing selective androgen rece...

Read the full pregnancy detail

BreastfeedingPossibly Unsafe

When used orally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing selective androgen rece...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Testolone, also known by the code name RAD-140, is a man-made chemical called a selective androgen receptor modulator (SARM). It is not an herb, plant, or natural dietary supplement, even though it is often sold next to supplements online and in some stores.

RAD-140 was originally created by a pharmaceutical company to study possible treatment of conditions like muscle wasting and certain cancers. It has never been approved by the U.S. Food and Drug Administration (FDA) for any use, and human research is very limited.

People who buy Testolone usually do so to try to build muscle, lose body fat, or boost athletic performance. Products labeled as SARMs are frequently mislabeled, contain other drugs, or contain different amounts than the label says.

How it works

Testolone is designed to attach to androgen receptors, the same receptors that respond to testosterone. The idea behind SARMs is that they might stimulate muscle and bone tissue while having fewer effects on other organs than traditional anabolic steroids.

In laboratory and animal studies, RAD-140 appears to encourage muscle growth. However, these results are mostly from preclinical research, and the way it behaves in the human body is not fully understood.

Despite marketing claims, SARMs are not free of hormone-related side effects. They can disrupt the body's own hormone balance and affect organs such as the liver.

Effectiveness

Does Testolone work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by Dr. Brian Staiger, PharmD.

Evidence overview · 8 uses evaluated

8 Insufficient evidence

How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.

2Likely EffectiveGood evidence, though not yet conclusive.

3Possibly EffectiveSome evidence suggests a benefit.

4Possibly IneffectiveSome evidence it may not help.

5Likely IneffectiveFairly strong evidence it doesn’t help.

6IneffectiveStrong evidence it doesn’t work.

7Insufficient Reliable Evidence to RateToo little research to say either way.

For Testolone, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 8 conditions — evidence insufficient to rate

Insufficient Reliable Evidence To Rate Athletic performance