Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Pro-Comp Ingredients & Drug Interactions

by Landmark Research

Pro-Comp label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pro-Comp against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pro-Comp is a dietary supplement by Landmark Research with 4 active ingredients. Its ingredients are commonly taken for muscle building, athletic performance and bodybuilding, strength gains.Based on those ingredients, 371 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are RAD 140, Andarin S4. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pro-Comp by Landmark Research

Ask about any prescription or over-the-counter medication and we check it for interactions with Pro-Comp by Landmark Research — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Pro-Comp by Landmark Research

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Pro-Comp contains four active ingredients: RAD 140 (testolone), GW 501516, SR9009 (stenabolic), and Andarin S4 (andarine). All four are experimental research chemicals not approved for human use.

The product also contains inactive ingredients — gelatin, silica, and rice flour — which are fillers and capsule materials.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: body recomposition and athletic performance.
  • We looked for evidence on: Athletic performance, Muscle strength, Obesity, Sarcopenia, fat loss, muscle gain — and 1 related terms.
  • The closest evidence on file: Stenabolic is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Stenabolic is rated "Insufficient Reliable Evidence To Rate" for Obesity.
  • Also on file: Testolone is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Muscle strength, Sarcopenia.

The evidence for effectiveness is insufficient across the board. For RAD 140, there's not enough reliable data to rate its use for athletic performance, muscle strength, osteoporosis, cachexia (wasting), or breast cancer.

SR9009 similarly lacks sufficient evidence for athletic performance, diabetes, or obesity. Andarin S4 has no effectiveness ratings on file.

In short, we don't have established data showing any of these ingredients work for their claimed purposes in humans.

The evidence, ingredient by ingredient Testolone Stenabolic Andarine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

This product carries serious safety concerns. RAD 140 is an unapproved experimental drug with reported serious risks and should not be used.

The most common adverse effects include decreased appetite, dehydration, elevated liver enzymes, vomiting, and weight loss. Rare but serious effects include acute heart inflammation (myocarditis), liver injury, and abnormal minerals in the blood.

SR9009 is an untested research chemical with no human safety data and is not legal to sell as a supplement. Andarin S4 is likewise unapproved with unknown human safety, and the FDA has warned that drugs like it may increase the risk of heart attack and stroke.

All three ingredients with safety data are marked possibly unsafe in pregnancy and lactation and should be avoided entirely during these times.

Side effects, ingredient by ingredient Testolone Stenabolic Andarine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Andarine, Testolone.
  • The most serious interaction on file is rated Moderate.
  • For scale: 372 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you take any medications that stress the liver (hepatotoxic drugs) — RAD 140 may compound that damage. Also flag any male-hormone drugs (androgens) you're on, since Andarin S4 may intensify androgenic side effects.

GW 501516 and SR9009 have not been checked for interactions with medications in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product contains experimental research chemicals that are not approved for human use and carry documented serious risks including liver injury, heart inflammation, and heart attack. If you're considering this, talk to your pharmacist first — the safety profile and lack of proven benefit make it a high-risk choice.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 22, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pro-Comp, straight from the product label.

Brand Landmark Research
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Dec 22, 2019
DSLD ID 210029
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pro-Comp by Landmark Research, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
120
IngredientAmount% DV
RAD 1405 mg--
GW 5015165 mg--
SR90097.5 mg--
Andarin S412.5 mg--

Other ingredients: Gelatin, Silica, Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

12 week recompositioning SARM compound Research SARMs

General Statements

Clinical grade

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pro-Comp by Landmark Research label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pro-Comp label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pro-Comp by Landmark Research

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

RAD 140

Interacts with
370 drugs
5 mg per serving

Testolone (RAD-140) is a synthetic experimental drug called a selective androgen receptor modulator (SARM), not a dietary supplement or herb, and it i...

RAD 140 monograph & interactions

GW 501516

5 mg per serving

SR9009

No known
interactions
7.5 mg per serving

Stenabolic (also called SR9009) is an experimental research chemical, not a true dietary supplement, herb, or approved drug. It is sold online for fat...

SR9009 monograph & interactions

Andarin S4

Interacts with
9 drugs
12.5 mg per serving

Andarine (S-4) is a synthetic selective androgen receptor modulator (SARM) that is not approved by the FDA for human use and is banned in sports. It i...

Andarin S4 monograph & interactions

Other (inactive) ingredients: Gelatin, Silica, Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pro-Comp by Landmark Research Drug Interactions

Want to check YOUR meds against Pro-Comp?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
371Drugs
371 Moderate

Ingredients driving the most interactions

RAD 140 370
Andarin S4 9

Individual Drug Interactions

The ingredients in Pro-Comp interact with 371 drugs. Click any drug to see the details.

2 of the 4 ingredients in Pro-Comp interact with drugs. Each result below shows which ingredient is responsible. RAD 140 Andarin S4

Each ingredient & the kinds of drugs it affects

For each ingredient in Pro-Comp with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

RAD 1401 drug type · 370 drugs

Hepatotoxic Drugs

Theoretically, concomitant use might have additive hepatotoxic effects.
In a case report, a 52-year-old male was diagnosed with liver injury thought to be related to the use of products containing testolone. Also, elevated liver enzymes were commonly reported in a dose escalation study of testolone.

Likelihood Possible Evidence B
RAD 140 full monograph & interactions

Andarin S41 drug type · 9 drugs

Androgens

Due to its androgenic properties, Andarine (S-4) may theoretically interact with other androgenic drugs, potentially increasing the risk of side effects associated with androgenic activity (source: https://pubmed.ncbi.nlm.nih.gov/12604714/). These side effects can include masculinization, virilization, acne, hair loss, increased libido, aggression, mood changes, and liver toxicity.

Likelihood Possible Evidence C
Andarin S4 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pro-Comp, from the product label.

Landmark Research

See all Landmark Research products
Name
Landmark Research
Pharmacist Counseling Corner

Pro-Comp by Landmark Research: Common Questions

Does Pro-Comp by Landmark Research interact with any medications?
Yes. Based on its ingredients, Pro-Comp has a known interaction with 371 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pro-Comp contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this product approved by the FDA?
No. RAD 140, SR9009, and Andarin S4 are all unapproved experimental or research chemicals. SR9009 and Andarin S4 are not legal to sell as supplements. These are not regulated like normal dietary supplements.
Can I take this if I'm pregnant or breastfeeding?
No. RAD 140 is hormonally active and unstudied in pregnancy — don't use it. SR9009 and Andarin S4 have no safety data in pregnancy or lactation and should be avoided completely. Talk to your doctor before considering any supplement during pregnancy or while nursing.
What are the most common side effects?
With RAD 140, the most common side effects reported in studies are decreased appetite, dehydration, elevated liver enzymes, vomiting, and weight loss. Rare but serious effects include heart inflammation and liver injury. The other three ingredients lack human safety data, so their side effect profiles are unknown.
Does this product actually work for athletic performance?
We don't have reliable evidence that any of the four ingredients work for athletic performance in humans. All the effectiveness ratings for these experimental chemicals are insufficient to rate.
Why would anyone take an unapproved drug?
These are marketed as performance or physique enhancers, but they remain experimental. The lack of approval, unknown full safety profile, and documented serious risks — including liver injury and heart problems — make them high-risk choices with unproven benefits.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pro-Comp is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pro-Comp label
Go deeper

The Full Monographs Behind Pro-Comp’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Testolone

Interacts with 370 drugs

Testolone (RAD-140) is a synthetic experimental drug called a selective androgen receptor modulator (SARM), not a dietary supplement or herb, and it is not approved or proven safe for human...

Read the full Testolone monograph → Herb & supplement monograph

Stenabolic

Stenabolic (also called SR9009) is an experimental research chemical, not a true dietary supplement, herb, or approved drug. It is sold online for fat loss and endurance, but it has never be...

Read the full Stenabolic monograph → Herb & supplement monograph

Andarine

Interacts with 9 drugs

Andarine (S-4) is a synthetic selective androgen receptor modulator (SARM) that is not approved by the FDA for human use and is banned in sports. It is not a legal dietary supplement ingredi...

Read the full Andarine monograph →
Sources

Sources & How We Checked

Pro-Comp's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Testolone 7 references
  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
  2. Warning Letter: Ironmag Labs 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582464.htm Accessed: November 1, 2017
  3. Warning Letter: Panther Sports Nutrition 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm581630.htm. Accessed: November 1, 2017
  4. Warning Letter: Infantry Labs LLC 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582685.htm. Accessed: November 1, 2017
  5. LoRusso P, Hamilton E, Ma C, et al. A first-in-human phase 1 study of a novel selective androgen receptor modulator (SARM), RAD140, in ER+/HER2- metastatic breast cancer. Clin Breast Cancer 2022;22(1):67-77. PubMed
  6. Barbara M, Dhingra S, Mindikoglu AL. Drug-induced liver injury associated with alpha bolic (RAD-140) and alpha elite (RAD-140 and LGD-4033). ACG Case Rep J 2020;7(6):e00409. PubMed
  7. Padappayil RP, Chandini Arjun A, Vivar Acosta J, Ghali W, Mughal MS. Acute myocarditis from the use of selective androgen receptor modulator (SARM) RAD-140 (Testolone). Cureus. 2022;14(1):e21663. PubMed

See these in context on the Testolone monograph →

Stenabolic 1 reference
  1. What Should Tested Athletes Know About GW1516? Education, Spirit of Sport. U.S. Anti-Doping Agency (USADA). September 24, 2019. Available at: https://www.usada.org/spirit-of-sport/education/what-should-athletes-know-gw1516/

See these in context on the Stenabolic monograph →

Andarine 1 reference
  1. FDA. FDA Warns against using SARMs in body building products. October 2017. Available at: https://www.fda.gov/newsevents/newsroom/fdainbrief/ucm583021.htm.

See these in context on the Andarine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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