Drug & supplement interaction

Andarine + Testosterone

Testosterone brand names: Intrinsa, Testim, Androgel, Andropatch, Testogel, and others.

Moderate Interaction
Medically reviewed by · Updated February 2024
The bottom line Moderate

Andarine has a moderate interaction with Testosterone. Due to its androgenic properties, Andarine (S-4) may theoretically interact with other androgenic drugs, potentially increasing the risk of side effects associated with androgenic activity (source: https://pubmed.ncbi.nlm.nih.gov/12604714/).

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceC
What do Severity, Likelihood & Evidence mean?
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Interaction report

Andarine and Testosterone

Here is the interaction we found between these two, with the evidence behind it.

Moderate

Androgens

Why this applies to Testosterone

Testosterone falls under Androgens — the group Andarine interacts with.

Due to its androgenic properties, Andarine (S-4) may theoretically interact with other androgenic drugs, potentially increasing the risk of side effects associated with androgenic activity (source: https://pubmed.ncbi.nlm.nih.gov/12604714/). These side effects can include masculinization, virilization, acne, hair loss, increased libido, aggression, mood changes, and liver toxicity.
Severity Moderate Likelihood Possible Evidence C

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: both testosterone and Andarine work on the same target, your androgen receptors. Andarine is a SARM built to act like testosterone in your body. So putting the two together is like pressing on the same pedal twice. You don't get a new kind of interaction, you just get more androgen activity stacked on top of your prescribed dose.

In real terms, that can mean more of testosterone's known effects: acne, oily skin, hair thinning, mood swings or irritability, a higher red blood cell count, and added strain on the liver. This is rated a possible, theoretical concern, so it isn't proven, but the overlap is real. On top of that, Andarine isn't FDA approved or legal as a supplement, and we don't recommend it. Please talk with your doctor or pharmacist before combining anything with your testosterone.

Contact Dr. Brian directly if you have additional questions on this interaction

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Andarine Also Interacts With Other Medications

Andarine has 8 moderate known drug interactions in our database — the Testosterone one above is one of them. If you take anything else, check it against the full list below.

Moderate 8 No known interaction 2,822 (incl. Testosterone)
Taking anything else?

Check Another of Your Medications Against Andarine

Covers the 2,830 medications we’ve checked against Andarine. Pick one to open its full report.

From our Q&A

Questions About Andarine or Testosterone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Andarine or Testosterone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Testosterone

This page covers Andarine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Testosterone page lists 170 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Beer (major), Grapefruit (major), Siberian Cocklebur (major), St. John's Wort (major) and Wine (major).

By severity: 5 major · 129 moderate · 36 minor.

From our pharmacist’s overview on the Testosterone page

“The supplement list for testosterone therapy (Androgel, Testim, Nebido, and others) deserves real attention, mainly because five of its 170 entries are rated major and four of those are everyday items: grapefruit, St. John's wort, and alcohol in the form of beer or wine.”

Reviewed by 2 · Jul 18, 2026

Open the Testosterone interaction page

One more smart check

Taking Andarine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 13 real supplement products containing Andarine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Andarine. Your product may carry other ingredients that interact with Testosterone too, on top of Andarine — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Andarine and Testosterone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Andarine
Steady interest

#1,088 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Testosterone
Top 1%

#15 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Andarine

What is Andarine?

Andarine
  • Muscle building
  • Strength gains
  • Fat loss / body recomposition
  • Athletic performance enhancement
  • Bone density support

Andarine (S-4) is a synthetic selective androgen receptor modulator (SARM) that is not approved by the FDA for human use and is banned in sports. It is not a legal dietary supplement ingredient, its long-term safety in people is unknown, and reported side effects include vision changes and possible liver and hormone problems. Because of these risks and its illegal status, we do not recommend using it.

Read the full Andarine monograph & all interactions
Medication

About Testosterone

What Is Testosterone Used For?

Brand names: Intrinsa, Testim, Androgel, Andropatch, Testogel, Nebido, Delatestryl, Natesto, Vogelxo

Testosterone replacement therapy is used in adult males whose bodies do not produce enough of their own testosterone. This includes primary hypogonadism — where the testes themselves fail due to causes such as Klinefelter's syndrome, injury, chemotherapy, or surgical removal — and hypogonadotropic hypogonadism, where the brain's signaling system (the hypothalamus or pituitary gland) fails to trigger testosterone production.

Testopel (subcutaneous pellets) may also be used to stimulate puberty in carefully selected males with clearly delayed puberty. The safety and efficacy of testosterone for age-related (late-onset) hypogonadism have not been established for most products, including AndroGel, Testim, Jatenzo, Kyzatrex, Natesto, Depo-Testosterone, Testosterone Cypionate, and Xyosted.

See full Testosterone drug information
Keep checking

Other Drugs & Andarine

Browse every other medication we’ve checked against Andarine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
8Moderate
0Minor
2,821No known interaction
8 Moderate 2,821 No interaction
Moderate

8 interactions

No interaction 2,821 drugs checked — show the list

We also checked Andarine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,821 medications checked with no known interaction — see the full Andarine list.

See the full Andarine interactions page
See every supplement checked against Testosterone, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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Pharmacist Counseling Corner

Taking Andarine and Testosterone Together: Common Questions

Can you take Andarine with Testosterone?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Andarine and Testosterone interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Testosterone and Andarine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.