Herb & supplement monograph

Andarine Drug Interactions, Uses, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Andarine interacts with medications. The heart of this page is the interaction list — every drug Andarine is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Andarine is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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On this page

Andarine Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Andarine drug interaction appears low for most people. None of the listed interactions are rated major, and every one of them rests on theoretical reasoning rather than documented reactions in people.

Interactions deserving the most attention

The interactions that deserve the most attention involve androgens, meaning testosterone-like medications. Because Andarine acts on the same hormone receptors these drugs target, combining them could add up their effects and raise the chance of side effects such as acne, hair loss, mood changes, aggression, or stress on the liver. This concern comes from what we know about how Andarine works, not from reports of actual harm in people, so we treat it as a sensible caution rather than a proven danger.

What the rest of the list means

Andarine's interaction list is fairly short, and every entry on it is theoretical. A moderate rating here reflects what could happen based on the compound's hormone-like activity, not effects that have been confirmed in human studies. So far, no combination on this list has been shown to cause a meaningful problem in people.

Check your medications against Andarine

Based on HelloPharmacist’s Andarine interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Andarine

9 medications have a known interaction with Andarine, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
Conjugated Estrogens, MethyltestosteronePremarin with Methyltestosterone› Diethylstilbestrol, MethyltestosteroneTylosterone› Esterified Estrogens, MethyltestosteroneEstratest› MethyltestosteroneAndroid 10, Android 25, Metandren, Methitest, Oreton, Testred +1 more› Methyltestosterone BuccalAndroid 5, Oreton Buccal› TestosteroneAndrogel, Andropatch, Delatestryl, Intrinsa, Natesto, Nebido +3 more› Testosterone EnanthateXyosted› Testosterone UndecanoateAndriol, Aveed, Jatenzo, Kyzatrex› TiboloneLivial› "phentolamineOraVerse, Rogitine, Ryzumvi› 6-mercaptopurinePurinethol› Ado-trastuzumab EmtansineKadcyla› AbacavirZiagen› Abacavir Sulfate, Dolutegravir, LamivudineTriumeq› Abacavir, LamivudineEpzicom› AbaloparatideTymlos› AbametapirXeglyze› AbarelixPlenaxis› AbciximabReoPro› AbemaciclibVerzenio› Abiraterone› Abiraterone AcetateYonsa, Zytiga› AbrocitinibCibinqo› AcalabrutinibCalquence› AcamprosateCampral› AcarboseGlucobay, Prandase, Precose› AcebutololRhotral, Sectral› AcenocoumarolSintrom› AcepromazineAtravet› AcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength›
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Andarine combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Andarine affects

Every type of medication (drug category) Andarine is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Andarine interacts with
Androgens
Androgens

Due to its androgenic properties, Andarine (S-4) may theoretically interact with other androgenic drugs, potentially increasing the risk of side effects associated with androgenic activity (source: https://pubmed.ncbi.nlm.nih.gov/12604714/). These side effects can include masculinization, virilization, acne, hair loss, increased libido, aggression, mood changes, and liver toxicity.

Likelihood Possible Evidence C
Monograph

Andarine: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Andarine (S-4) is a synthetic selective androgen receptor modulator (SARM) that is not approved by the FDA for human use and is banned in sports. It is not a legal dietary supplement ingredient, its long-term safety in people is unknown, and reported side effects include vision changes and possible liver and hormone problems. Because of these risks and its illegal status, we do not recommend using it.

Andarine
Part used
Not applicable (synthetic chemical compound)
Common forms
Capsules, tablets, liquid solutions (sold as research chemicals)
People commonly use it for
  • Muscle building
  • Strength gains
  • Fat loss / body recomposition
  • Athletic performance enhancement
  • Bone density support

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallBest avoided

Andarine is an unapproved drug with unknown human safety and is not a legal supplement.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Andarine, often called S-4, is a man-made chemical known as a selective androgen receptor modulator (SARM). It is not a plant or herb. It was first developed in a laboratory as a possible treatment for conditions like muscle wasting and bone loss, but it was never approved as a medicine.

People sometimes buy Andarine online as a so-called "research chemical" hoping to build muscle, lose fat, or boost athletic performance. It is not approved by the FDA for human use and is not legal to sell as a dietary supplement in the United States. Products containing it are often mislabeled or contain unknown amounts of the drug.

Uses & effectiveness

People mainly use Andarine in an attempt to gain muscle, increase strength, improve bone density, and lose body fat. These uses come from bodybuilding and fitness communities, not from approved medical practice.

The evidence in humans is very limited. Most of what we know comes from early laboratory and animal studies, which suggested it could increase muscle and bone in rodents while having weaker effects on the prostate than testosterone. However, animal results do not prove that something is safe or effective in people. There are no large, high-quality human trials confirming benefits, and Andarine has not completed the testing needed for approval as a drug.

Because of the lack of proof and the safety concerns, the supposed benefits do not outweigh the risks.

How it works

Andarine is designed to attach to androgen receptors, the same receptors that the hormone testosterone uses. The idea behind SARMs is that they can target muscle and bone tissue more than other tissues like the prostate, in the hope of building muscle with fewer side effects than anabolic steroids.

In animal research, Andarine appeared to stimulate muscle growth and support bone-building cells while having weaker effects on some other hormone-sensitive tissues. It is also reported to have only minor effects on certain pituitary hormones compared with testosterone.

It is important to understand that these mechanisms are based mostly on laboratory and animal studies. How Andarine truly behaves in the human body over time is not well understood.

Safety & precautions

Andarine is not approved for human use, and its safety in people has not been established. Products sold online are unregulated, so you often cannot be sure what is actually in them or how much.

One well-known issue reported by users is vision changes, such as a yellowish tint to vision or trouble adjusting to light or dark. SARMs as a group have also been linked to possible liver injury and to suppression of the body's own testosterone production.

Pregnancy and breastfeeding: Andarine should be avoided completely. A drug that affects hormones could harm a developing baby, and there is no safety information for use while nursing.

Athletes should know that Andarine is banned by the World Anti-Doping Agency (WADA) and most sports organizations, and using it can lead to a failed drug test. Anyone considering it should talk with a doctor or pharmacist first—our recommendation is to avoid it.

Side effects

Because Andarine is not approved and not well studied in humans, its full side effect profile is unknown. Reported and possible effects include:

  • Vision changes, such as yellow-tinted vision or difficulty seeing in low light
  • Possible liver strain or injury
  • Suppression of natural testosterone, which can affect mood, energy, and sexual function
  • Hormone-related effects such as changes in libido

Serious or long-term risks have not been fully measured. Because the products are unregulated, contamination with other substances is also a real concern. Stop use and seek medical care if you notice vision problems, yellowing of the skin or eyes, dark urine, or severe fatigue.

Andarine: Reported Adverse Effects

Documented safety reports on Andarine from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, selective androgen receptor modulators, such as andarine, could potentially increase the risk of myocardial infarction, stroke, and liver toxicity. However, no thorough safety evaluations of andarine have been conducted.

  1. FDA. FDA Warns against using SARMs in body building products. October 2017. Available at: https://www.fda.gov/newsevents/newsroom/fdainbrief/ucm583021.htm.
Reports by condition
Myocardial infarction (MI) Cardiovascular

The FDA has warned that selective androgen receptor modulators, such as andarine, could potentially increase the risk of myocardial infarction and stroke.

  1. FDA. FDA Warns against using SARMs in body building products. October 2017. Available at: https://www.fda.gov/newsevents/newsroom/fdainbrief/ucm583021.htm.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no established or approved dose for Andarine because it is not a recognized medicine or legal supplement. We cannot recommend a safe dose, and doses circulated online are not backed by proper human research.

Given that it is unapproved, potentially unsafe, and illegal to sell as a supplement, the safest choice is not to use it at all. If you are looking to build muscle or improve performance, talk with a pharmacist or doctor about proven and legal options.

Pregnancy & Breastfeeding

Andarine & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Andarine & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 1 references that drive our Andarine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. FDA. FDA Warns against using SARMs in body building products. October 2017. Available at: https://www.fda.gov/newsevents/newsroom/fdainbrief/ucm583021.htm.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Andarine

11 brands in our database make a supplement containing Andarine.

Product directory

Supplement products with Andarine

13 products in our database contain Andarine. Open any to see its full ingredient list and every drug interaction we check.

Pharmacist Counseling Corner

Andarine: Common Questions

Does Andarine interact with prescription medications?
Yes. We list 9 medications with a known interaction with Andarine. Use the checker above to see how Andarine interacts with a specific drug.
How are Andarine interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Andarine with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Andarine interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
Is Andarine a legal dietary supplement?
No. Andarine is an unapproved drug, not a legal dietary supplement ingredient in the United States. Products selling it are often marketed as "research chemicals" and are not FDA-approved or quality-controlled.
Is Andarine safe to take?
Its safety in humans has not been established. Reported problems include vision changes, possible liver injury, and suppressed natural testosterone, so we recommend avoiding it.
Why do some people get yellow-tinted vision from Andarine?
Vision changes, including a yellow tint or trouble seeing in dim light, are commonly reported by Andarine users. The exact cause is not fully understood, and it is one reason this compound is concerning.
Will Andarine cause a failed drug test?
Yes. Andarine and other SARMs are banned by WADA and most sports organizations, and using it can result in a positive doping test.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Keep exploring

Products that contain Andarine

A rotating sample of real supplements in our database that list Andarine — open any to see its full ingredients and every drug interaction we check.

See all 13 products with Andarine →
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