Andarine + Diethylstilbestrol, Methyltestosterone
Diethylstilbestrol, Methyltestosterone brand name: Tylosterone.
Andarine has a moderate interaction with Diethylstilbestrol, Methyltestosterone. Due to its androgenic properties, Andarine (S-4) may theoretically interact with other androgenic drugs, potentially increasing the risk of side effects associated with androgenic activity (source: https://pubmed.ncbi.nlm.nih.gov/12604714/).
Read the full interaction reportAndarine and Diethylstilbestrol, Methyltestosterone
Here is the interaction we found between these two, with the evidence behind it.
Androgens
Why this applies to Diethylstilbestrol, Methyltestosterone
Diethylstilbestrol, Methyltestosterone falls under Androgens — the group Andarine interacts with.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
The medication you're asking about includes methyltestosterone, which is itself an androgen (a male-type hormone). Andarine (S-4) is a SARM that acts on those very same androgen receptors. So instead of two different mechanisms clashing, you'd basically be stacking one androgen on top of another. That adds up, and the worry is simply more androgen activity than your body would get from the prescription alone.
In real terms, that could mean more acne, oily skin, hair loss, mood swings or irritability, and a higher chance of liver strain, plus masculinizing effects that hit especially hard for women. Keep in mind this is a theoretical, lower-evidence concern, but Andarine is also illegal and unstudied in people. Please loop in your doctor or pharmacist before combining anything here.
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Andarine Also Interacts With Other Medications
Andarine has 8 moderate known drug interactions in our database — the Diethylstilbestrol, Methyltestosterone one above is one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Andarine
We haven’t checked that one against Andarine yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Andarine. Pick one to open its full report.
See Every Supplement That Interacts With Diethylstilbestrol, Methyltestosterone
This page covers Andarine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diethylstilbestrol, Methyltestosterone page lists 73 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and 1-androsterone (moderate).
By severity: 4 major · 53 moderate · 16 minor.
From our pharmacist’s overview on the Diethylstilbestrol, Methyltestosterone page
“Tylosterone pairs diethylstilbestrol, an estrogen, with methyltestosterone, an oral androgen already known for stressing the liver, and that is exactly where this interaction list concentrates. I would handle these 73 supplements carefully.”
Reviewed by 2 · Jul 18, 2026
Open the Diethylstilbestrol, Methyltestosterone interaction page
Taking Andarine as Part of a Dietary Supplement Product? Check It for Interactions
We hold 13 real supplement products containing Andarine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Andarine. Your product may carry other ingredients that interact with Diethylstilbestrol, Methyltestosterone too, on top of Andarine — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Andarine and Diethylstilbestrol, Methyltestosterone Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,040 of 1,452 supplements looked up here in the last 7 days
#286 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Andarine
What is Andarine?
- Muscle building
- Strength gains
- Fat loss / body recomposition
- Athletic performance enhancement
- Bone density support
Andarine (S-4) is a synthetic selective androgen receptor modulator (SARM) that is not approved by the FDA for human use and is banned in sports. It is not a legal dietary supplement ingredient, its long-term safety in people is unknown, and reported side effects include vision changes and possible liver and hormone problems. Because of these risks and its illegal status, we do not recommend using it.
Other Drugs & Andarine
Browse every other medication we’ve checked against Andarine — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
8 interactions
No interaction 2,821 drugs checked — show the list
We also checked Andarine against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Ivermectin ›
- Abemaciclib ›
- Sertraline ›
- Losartan Potassium ›
- Acetaminophen ›
- Rosuvastatin ›
- Aspirin ›
- Escitalopram ›
- Metoprolol ›
- Clopidogrel ›
- Atorvastatin ›
- Rivaroxaban ›
- Isotretinoin ›
- Tirzepatide ›
- Warfarin Sodium ›
- Ibuprofen ›
- Methamphetamine ›
- Amlodipine Besylate ›
- Docusate ›
- Valacyclovir ›
- Metformin ›
- Prednisone ›
- Sumatriptan ›
- Hydroxyurea ›
- Tadalafil ›
- Amitriptyline ›
- Levothyroxine, Liothyronine ›
- Semaglutide ›
- Lisdexamfetamine ›
- Propranolol ›
- Amphetamine ›
- Methotrexate ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Fluoxetine ›
- Azithromycin ›
- Doxycycline ›
- Pregabalin ›
- Bendamustine ›
- Gabapentin ›
- Dextroamphetamine ›
- Lamotrigine ›
- Naproxen ›
- Acetaminophen, Aspirin, Caffeine ›
- Acyclovir ›
- Quetiapine ›
- Clonazepam ›
- Buspirone ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Citalopram ›
- Methylene Blue ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,821 medications checked with no known interaction — see the full Andarine list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Taking Andarine and Diethylstilbestrol, Methyltestosterone Together: Common Questions
Can you take Andarine with Diethylstilbestrol, Methyltestosterone?
How serious is the Andarine and Diethylstilbestrol, Methyltestosterone interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.