Medication interaction hub

What Supplements Interact with Diethylstilbestrol, Methyltestosterone?

Diethylstilbestrol, Methyltestosterone brand name: Tylosterone. Every interaction below applies to the brands too.

73 Interactions 4 Major 53 Moderate 16 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Diethylstilbestrol, Methyltestosterone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Diethylstilbestrol, Methyltestosterone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Tylosterone pairs diethylstilbestrol, an estrogen, with methyltestosterone, an oral androgen already known for stressing the liver, and that is exactly where this interaction list concentrates. I would handle these 73 supplements carefully. Thirty-eight of them can injure the liver on their own, so stacking any onto this hormone combination compounds the danger. Siberian cocklebur is the sharpest hazard, with documented cases of liver failure, and alcohol, whether beer or wine, rates major for the same reason.

The other big theme is absorption. Seventeen ingredients, activated charcoal chief among them, can keep the tablet from being fully taken up, so space those well apart from your dose. Eighteen more are testosterone boosters and androgen products that add to methyltestosterone's own side effects, from mood changes to heart and kidney strain. Only 4 of the 73 rate major, alongside 53 moderate and 16 minor, but the liver risk threading through this page deserves your closest attention.

— , Clinical Pharmacist · July 18, 2026

Major 4 Moderate 53 Minor 16 No known interaction 1,379

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Diethylstilbestrol, Methyltestosterone: Top Interactions at a Glance

The most significant Diethylstilbestrol, Methyltestosterone supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 73 interacting ingredients — plus 1,379 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Diethylstilbestrol, Methyltestosterone + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Siberian Cocklebur + Diethylstilbestrol, Methyltestosteronei

Siberian cocklebur can adversely affect the liver.

Read the full interaction Major Likelihood Probable Activated Charcoal + Diethylstilbestrol, Methyltestosteronei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Beer + Diethylstilbestrol, Methyltestosteronei

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction Major Likelihood Probable Wine + Diethylstilbestrol, Methyltestosteronei

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction
The complete list

Every Supplement Checked Against Diethylstilbestrol, Methyltestosterone

All 1,452 ingredients in our database, ranked by severity — 73 with a Diethylstilbestrol, Methyltestosterone interaction on file and 1,379 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Diethylstilbestrol, Methyltestosterone?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Cordyceps with Diethylstilbestrol, Methyltestosterone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concurrent use of cordyceps and testosterone might have additive effects.

Full Cordyceps + Diethylstilbestrol, Methyltestosterone answer

Can you take Dhea with Diethylstilbestrol, Methyltestosterone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, DHEA might increase the effects and side effects of testosterone therapy.

Full Dhea + Diethylstilbestrol, Methyltestosterone answer

Can you take Eurycoma Longifolia with Diethylstilbestrol, Methyltestosterone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Eurycoma longifolia may further increase levels of testosterone.

Full Eurycoma Longifolia + Diethylstilbestrol, Methyltestosterone answer

Can you take Karaya Gum with Diethylstilbestrol, Methyltestosterone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Diethylstilbestrol, Methyltestosterone answer

Can you take L-arginine with Diethylstilbestrol, Methyltestosterone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of L-arginine and testosterone might have additive effects.

Full L-arginine + Diethylstilbestrol, Methyltestosterone answer

Can you take Marshmallow with Diethylstilbestrol, Methyltestosterone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Diethylstilbestrol, Methyltestosterone answer

Can you take Xanthan Gum with Diethylstilbestrol, Methyltestosterone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Diethylstilbestrol, Methyltestosterone answer

Can you take Siberian Cocklebur with Diethylstilbestrol, Methyltestosterone?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Siberian cocklebur can adversely affect the liver.

Full Siberian Cocklebur + Diethylstilbestrol, Methyltestosterone answer

Can you take Activated Charcoal with Diethylstilbestrol, Methyltestosterone?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Diethylstilbestrol, Methyltestosterone answer

Can you take Beer with Diethylstilbestrol, Methyltestosterone?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Full Beer + Diethylstilbestrol, Methyltestosterone answer

Can you take Wine with Diethylstilbestrol, Methyltestosterone?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Full Wine + Diethylstilbestrol, Methyltestosterone answer

Can you take Coffee Charcoal with Diethylstilbestrol, Methyltestosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Diethylstilbestrol, Methyltestosterone answer

Can you take European Mandrake with Diethylstilbestrol, Methyltestosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Diethylstilbestrol, Methyltestosterone answer

Can you take Glucomannan with Diethylstilbestrol, Methyltestosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Diethylstilbestrol, Methyltestosterone answer

Can you take 1-androsterone with Diethylstilbestrol, Methyltestosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking 1-androsterone with testosterone might increase the risk for additive adverse effects such as mood disturbances and ca...

Full 1-androsterone + Diethylstilbestrol, Methyltestosterone answer

Can you take 19-nor-dhea with Diethylstilbestrol, Methyltestosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. 19-nor-DHEA is purportedly converted to nandrolone and other androgens upon ingestion.

Full 19-nor-dhea + Diethylstilbestrol, Methyltestosterone answer

Can you take 4-androsterone with Diethylstilbestrol, Methyltestosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. 4-Androsterone is purportedly converted to testosterone and other androgens upon ingestion.

Full 4-androsterone + Diethylstilbestrol, Methyltestosterone answer

Can you take 7-methoxyflavone with Diethylstilbestrol, Methyltestosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence shows that 7-methoxyflavone inhbits aromatase.

Full 7-methoxyflavone + Diethylstilbestrol, Methyltestosterone answer

Can you take Andarine with Diethylstilbestrol, Methyltestosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Due to its androgenic properties, Andarine (S-4) may theoretically interact with other androgenic drugs, potentially increasing the risk of...

Full Andarine + Diethylstilbestrol, Methyltestosterone answer

Can you take Androstenediol with Diethylstilbestrol, Methyltestosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Androstenediol is a precursor to testosterone and can increase levels of testosterone.

Full Androstenediol + Diethylstilbestrol, Methyltestosterone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Diethylstilbestrol, Methyltestosterone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Diethylstilbestrol, Methyltestosterone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Diethylstilbestrol, Methyltestosterone sits in 4 interaction categories. Open any one to see what the group means:

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Diethylstilbestrol, Methyltestosterone through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Diethylstilbestrol, Methyltestosterone through this category.

Testosterone 14 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

14 of the supplement ingredients on this page reach Diethylstilbestrol, Methyltestosterone through this category.

Androgens 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Diethylstilbestrol, Methyltestosterone through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Diethylstilbestrol, Methyltestosterone

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Diethylstilbestrol, Methyltestosterone.

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Products that contain Diethylstilbestrol, Methyltestosterone-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Diethylstilbestrol, Methyltestosterone.

Zi Sheng Teapills by Plum Flower contains Siberian Cocklebur Cold Away by Health Concerns contains Siberian Cocklebur Sugar Coated Bi Yan Pian by Plum Flower contains Siberian Cocklebur Pe Min Kan Wan by Plum Flower contains Siberian Cocklebur
Pharmacist Counseling Corner

Diethylstilbestrol, Methyltestosterone & Supplements: Common Questions

What supplements interact with Diethylstilbestrol, Methyltestosterone?
More than you might expect — 73 in total, though they are far from equal: 4 are rated major, 53 moderate, and 16 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Beer.
Which Diethylstilbestrol, Methyltestosterone supplement interactions are the most serious?
The 4 major-rated combinations — led by Siberian Cocklebur, Activated Charcoal, Beer and Wine — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Diethylstilbestrol, Methyltestosterone?
Usually yes — most people on Diethylstilbestrol, Methyltestosterone can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Tylosterone have the same supplement interactions as Diethylstilbestrol, Methyltestosterone?
Yes — Tylosterone all contain Diethylstilbestrol, Methyltestosterone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Diethylstilbestrol, Methyltestosterone and my other medications?
This page covers Diethylstilbestrol, Methyltestosterone against supplements and herbal ingredients. Checking Diethylstilbestrol, Methyltestosterone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.