Androsterone + Diethylstilbestrol, Methyltestosterone
Diethylstilbestrol, Methyltestosterone brand name: Tylosterone.
Androsterone has a minor interaction with Diethylstilbestrol, Methyltestosterone. Androsterone, as an androgenic hormone, may interact with other androgenic drugs, such as testosterone, due to their similar mechanisms of action.
Read the full interaction reportAndrosterone and Diethylstilbestrol, Methyltestosterone
Here is the interaction we found between these two, with the evidence behind it.
Androgens
Why this applies to Diethylstilbestrol, Methyltestosterone
Diethylstilbestrol, Methyltestosterone falls under Androgens — the group Androsterone interacts with.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the simple version. The product you asked about, Tylosterone, contains methyltestosterone, which is itself an androgen (a male-type hormone). Androsterone is also a weak androgen. So you'd essentially be stacking two hormones that pull on the same receptors. Rather than one canceling the other, they can add together and push androgen effects higher.
In real life that may mean more of the usual androgen side effects: oily skin and acne, scalp hair thinning, shifts in sex drive, mood changes, and over time disruption of your natural hormone balance. This is rated a minor, possible interaction on weaker evidence, so it's not an emergency. Still, androsterone is a banned, unproven steroid, so please don't combine them. Talk with your doctor or pharmacist first.
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Androsterone Also Interacts With Other Medications
Androsterone has 8 minor known drug interactions in our database — the Diethylstilbestrol, Methyltestosterone one above is one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Androsterone
We haven’t checked that one against Androsterone yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Androsterone. Pick one to open its full report.
See Every Supplement That Interacts With Diethylstilbestrol, Methyltestosterone
This page covers Androsterone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diethylstilbestrol, Methyltestosterone page lists 73 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and 1-androsterone (moderate).
By severity: 4 major · 53 moderate · 16 minor.
From our pharmacist’s overview on the Diethylstilbestrol, Methyltestosterone page
“Tylosterone pairs diethylstilbestrol, an estrogen, with methyltestosterone, an oral androgen already known for stressing the liver, and that is exactly where this interaction list concentrates. I would handle these 73 supplements carefully.”
Reviewed by 2 · Jul 18, 2026
Open the Diethylstilbestrol, Methyltestosterone interaction page
Taking Androsterone as Part of a Dietary Supplement Product? Check It for Interactions
We hold 12 real supplement products containing Androsterone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Androsterone. Your product may carry other ingredients that interact with Diethylstilbestrol, Methyltestosterone too, on top of Androsterone — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Androsterone and Diethylstilbestrol, Methyltestosterone Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,421 of 1,452 supplements looked up here in the last 7 days
#2,785 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Androsterone
What is Androsterone?
- Muscle building and athletic performance
- Boosting testosterone or androgen levels
- Supporting libido
- Bodybuilding 'prohormone' stacks
Androsterone is a natural androgenic steroid hormone made in the body, but supplement versions are classified as anabolic-androgenic steroids and are banned from U.S. dietary supplements under the DASCA law. There is no good evidence that taking it is safe or effective, and it carries the same hormone-related risks as other anabolic steroids. Avoid products that contain it, and talk to a pharmacist or doctor about safer, legal options.
Other Drugs & Androsterone
Browse every other medication we’ve checked against Androsterone — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
8 interactions
No interaction 2,821 drugs checked — show the list
We also checked Androsterone against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Aspirin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Acetaminophen ›
- Escitalopram ›
- Tadalafil ›
- Clopidogrel ›
- Abemaciclib ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Ibuprofen ›
- Methamphetamine ›
- Tirzepatide ›
- Semaglutide ›
- Warfarin Sodium ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Lisinopril ›
- Bupropion ›
- Amoxicillin ›
- Bendamustine ›
- Amitriptyline ›
- Acyclovir ›
- Methotrexate ›
- Doxycycline ›
- Fluoxetine ›
- Amphetamine ›
- Lamotrigine ›
- Pregabalin ›
- Acetaminophen, Codeine ›
- Azithromycin ›
- Gabapentin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Methylene Blue ›
- Omeprazole ›
- Amlodipine Besylate ›
- Quetiapine ›
- Letrozole ›
- Duloxetine ›
- Naproxen ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Bisoprolol ›
Showing the 60 most looked-up of 2,821 medications checked with no known interaction — see the full Androsterone list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Taking Androsterone and Diethylstilbestrol, Methyltestosterone Together: Common Questions
Can you take Androsterone with Diethylstilbestrol, Methyltestosterone?
How serious is the Androsterone and Diethylstilbestrol, Methyltestosterone interaction?
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