Androsterone + Tibolone
Tibolone brand name: Livial.
Androsterone has a minor interaction with Tibolone. Androsterone, as an androgenic hormone, may interact with other androgenic drugs, such as testosterone, due to their similar mechanisms of action.
Read the full interaction reportAndrosterone and Tibolone
Here is the interaction we found between these two, with the evidence behind it.
Androgens
Why this applies to Tibolone
Tibolone falls under Androgens — the group Androsterone interacts with.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the simple version. Tibolone (Livial) is a hormone medicine many women take after menopause. Once it's in your body, it turns into pieces that act in three ways: like estrogen, like progesterone, and a little bit like an androgen (the testosterone family of hormones). That androgen-like part is what overlaps with androsterone.
Since androsterone is itself a weak androgen, stacking it on top of Tibolone could add to the androgen-type effects. In real life that might look like more acne, oilier skin, unwanted hair changes, or shifts in libido. The interaction is rated minor and the evidence is fairly weak, so it isn't an emergency. Still, androsterone is banned in U.S. supplements and not worth the risk. Please check with your pharmacist or doctor before combining them.
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Androsterone Also Interacts With Other Medications
Androsterone has 8 minor known drug interactions in our database — the Tibolone one above is one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Androsterone
We haven’t checked that one against Androsterone yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Androsterone. Pick one to open its full report.
See Every Supplement That Interacts With Tibolone
This page covers Androsterone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tibolone page lists 80 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), Aletris (moderate), Alfalfa (moderate) and Andarine (moderate).
By severity: 2 major · 62 moderate · 16 minor.
From our pharmacist’s overview on the Tibolone page
“Grapefruit is the risk I would learn first with tibolone (Livial), a hormone therapy used for menopause symptoms. Grapefruit can raise estrogen levels in the blood, magnifying both the drug's effects and its side effects, and it shares major status with activated charcoal, which soaks up medications in the gut and can blunt tibolone's…”
Reviewed by 2 · Jul 18, 2026
Taking Androsterone as Part of a Dietary Supplement Product? Check It for Interactions
We hold 12 real supplement products containing Androsterone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Androsterone. Your product may carry other ingredients that interact with Tibolone too, on top of Androsterone — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Androsterone and Tibolone Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,244 of 1,452 supplements looked up here in the last 7 days
#2,815 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Androsterone
What is Androsterone?
- Muscle building and athletic performance
- Boosting testosterone or androgen levels
- Supporting libido
- Bodybuilding 'prohormone' stacks
Androsterone is a natural androgenic steroid hormone made in the body, but supplement versions are classified as anabolic-androgenic steroids and are banned from U.S. dietary supplements under the DASCA law. There is no good evidence that taking it is safe or effective, and it carries the same hormone-related risks as other anabolic steroids. Avoid products that contain it, and talk to a pharmacist or doctor about safer, legal options.
Other Drugs & Androsterone
Browse every other medication we’ve checked against Androsterone — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
8 interactions
No interaction 2,821 drugs checked — show the list
We also checked Androsterone against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Sumatriptan ›
- Ibuprofen ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
- Bisoprolol ›
Showing the 60 most looked-up of 2,821 medications checked with no known interaction — see the full Androsterone list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Tibolone Is Linked to Lower Levels of 5 Nutrients
Natural Medicines records Tibolone as a medicine that can lower these. This is not an interaction with Androsterone — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Tibolone nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Androsterone and Tibolone Together: Common Questions
Can you take Androsterone with Tibolone?
How serious is the Androsterone and Tibolone interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Tibolone and Androsterone?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.