Medications That May Deplete VITAMIN C
Vitamin C is an antioxidant that supports the immune system, collagen formation, and iron absorption. See which medications carry a reported association, how strong the evidence is, and what to discuss with your pharmacist.
Vitamin C is an antioxidant that supports the immune system, collagen formation, and iron absorption.
Common food sources: Citrus fruits; Bell peppers; Strawberries and kiwi; Broccoli and Brussels sprouts.
Frank vitamin C deficiency is uncommon with a varied diet. If your diet is limited and you take an associated medication, ask your provider whether your intake is adequate.
HelloPharmacist pharmacist-reviewed education. The medication records below are licensed clinical data, shown as published.
Deep dive: Vitamin C — uses, safety & drug interactions
Medications associated with VITAMIN C depletion
Each record is shown as published in our licensed clinical database. Open a medication for its full nutrient report.
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Acetaminophen, Aspirin
Insignificant DepletionBrand names include Gemnisyn
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your immune cells and connective tissue depend on, and aspirin can interfere with it in two ways: it limits how much your cells actually absorb and hold onto, and it may reduce how much you take in from food, leaving more to be flushed out through the kidneys. That said, this is rated as insignificant depletion, and the concern really only comes up with high, long-term aspirin doses, not the low daily doses most people take for heart health. For the typical person using low-dose aspirin, no extra vitamin C is generally needed, but if you have questions about your specific dose or situation, your pharmacist or doctor is a great place to start.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Acetaminophen, Aspirin, Caffeine
Insignificant DepletionBrand names include Excedrin Migraine, Excedrin, Excedrin Extra Strength
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Here's something worth knowing: the aspirin component in this combination can affect how your body handles vitamin C, which supports your immune system, skin, and healing. Aspirin appears to interfere with how cells take up vitamin C and may also limit how much is absorbed from the gut, causing more of it to pass out through the urine. That said, the evidence rates this as insignificant for most people, especially at the low aspirin doses found in headache combinations. If you happen to take high-dose aspirin regularly over a long period, it's worth mentioning to your pharmacist or doctor.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Acetaminophen, Caffeine, Pyrilamine
Insignificant DepletionBrand names include Midol Max Strength Menstrual
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your body uses to support your immune system, heal tissue, and protect cells from damage. There is some research suggesting that diuretics (water pills) can increase how much vitamin C the body flushes out through urine, but that connection has mainly been seen with intravenous furosemide in people with kidney disease, not with everyday oral medications. For a combination like acetaminophen, caffeine, and pyrilamine, any effect on vitamin C is considered insignificant, meaning most people taking it have nothing to worry about. No action is needed for the average user, but if you have concerns, your pharmacist is always a good place to start.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Full nutrient report for Acetaminophen, Caffeine, Pyrilamine →
Acetaminophen, Pamabrom, Pyrilamine
Insignificant DepletionBrand names include Midol Max Strength PMS, Pamprin, Pamprin ES
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
This combination product contains pamabrom, a mild diuretic that helps reduce water retention. Because diuretics increase how much urine your body produces, there is a theoretical possibility they could carry a little extra vitamin C (which supports your immune system, skin, and wound healing) out with that extra fluid. In practice, this effect has not been shown to cause any meaningful drop in vitamin C levels with regular use of oral diuretics like pamabrom, so most people taking this product do not need to worry about it or add a supplement. If you have any concerns, a quick conversation with your pharmacist is always a good idea.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Full nutrient report for Acetaminophen, Pamabrom, Pyrilamine →
Acetazolamide
Insignificant DepletionBrand names include Diamox, Ak-Zol
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it is worth knowing that diuretics like acetazolamide, which work partly by increasing the amount of fluid your kidneys flush out, may carry a little extra vitamin C out with that urine. That said, this has only been seen in specific situations involving intravenous doses of other diuretics, and meaningful vitamin C depletion has not been reported with regular oral use. For most people taking acetazolamide, this is not something that needs action, but if you have questions about your diet or whether a supplement makes sense for you personally, your pharmacist or doctor is a good person to ask.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Acetylsalicylic acid
Insignificant DepletionBrand names include Entrophen
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your immune cells and tissues depend on for repair and overall health. Here is an interesting quirk: aspirin appears to interfere with how your white blood cells and tissues take up vitamin C, which pushes more of it into the bloodstream where the kidneys can filter it out in urine. At the low doses most people use for heart health, though, this effect is considered insignificant, and a supplement is not something most people need to worry about. If you take high-dose aspirin regularly over a long period, it is worth mentioning to your pharmacist just to be sure.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide
Insignificant DepletionBrand names include Ascriptin Codeine #2
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your immune cells and connective tissue depend on to work properly. The aspirin in this combination has been shown to affect how well your cells hold onto vitamin C, and it may also reduce how much your gut absorbs, with both effects tied to the dose you take. At the low aspirin doses typically used for heart health, this is considered an insignificant concern, and most people do not need a supplement because of it. If you have questions about your specific dose or situation, your pharmacist is a great first stop.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Full nutrient report for Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide →
Aluminum Hydroxide, Aspirin, Magnesium Hydroxide
Insignificant DepletionBrand names include Ascriptin
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your immune cells and tissues depend on, and aspirin has a known tendency to affect how those cells hold onto it. At higher doses, aspirin can nudge the kidneys to flush more vitamin C out in the urine and may also reduce how much is absorbed from food. That said, this combination includes a low-dose aspirin, the kind typically used for heart health, and at that level the effect is considered insignificant for most people. No extra vitamin C is generally needed here, but if you have questions about your specific situation, your pharmacist or doctor is the right person to ask.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Full nutrient report for Aluminum Hydroxide, Aspirin, Magnesium Hydroxide →
Amiloride, Hydrochlorothiazide
Insignificant DepletionBrand names include Moduretic, Amilzide, Moduret 25
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and wound healing all depend on, so it is worth knowing a little about. Because amiloride and hydrochlorothiazide work by making your kidneys produce more urine, there is a theoretical possibility that some vitamin C could be carried out in that extra fluid. That said, meaningful depletion from oral diuretics like this combination has not been reported in practice, and the evidence rates this as insignificant for most people. No action is needed on your end, but if you ever want to talk through your diet or whether a supplement makes sense for you, your pharmacist or doctor is a good person to ask.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Ammonium Chloride
Insignificant DepletionIn people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your body needs to support your immune system, heal wounds, and keep connective tissue strong. Ammonium chloride works by acidifying your urine, and some diuretics in general have been loosely linked to washing a little extra vitamin C out through increased urine flow. That said, this interaction is rated insignificant, and real-world deficiency from oral use has not been reported. For most people taking ammonium chloride, no extra vitamin C is needed, though your pharmacist is always a good sounding board if you have concerns.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Aspirin
Insignificant DepletionBrand names include Children's Aspirin, Easprin, Ecotrin
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your immune cells and tissues depend on to stay healthy, and aspirin has a quirky effect on how your body handles it: at higher doses, aspirin appears to block cells from pulling vitamin C in from the bloodstream, so more of it ends up filtered out through the kidneys rather than being used. It may also reduce how much vitamin C gets absorbed from the gut in the first place. That said, this is rated as insignificant depletion, meaning at the low daily doses most people take aspirin for heart health, this likely has no real-world impact. If you happen to take high-dose aspirin regularly for another reason, it's worth a quick conversation with your pharmacist to see if anything needs attention.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide
Insignificant DepletionBrand names include Ascriptin Codeine #3
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your immune cells and tissues depend on for repair and overall health. Aspirin, particularly at higher doses taken long-term, can nudge your body to hold less of it in your cells and flush more of it out through urine, and it may also reduce how much you absorb from food. That said, at the low doses most people take aspirin for heart health, this effect is considered insignificant, so the vast majority of people do not need to do anything differently. If you are on high-dose aspirin regularly, it is worth a quick conversation with your pharmacist or doctor just to be sure.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Full nutrient report for Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide →
Aspirin, Butalbital
Insignificant DepletionBrand names include Axotal
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your body needs to support your immune system, heal tissue, and keep your cells healthy. The aspirin component of this medication can nudge your body to excrete more vitamin C through the urine, partly because it interferes with how your cells take up the vitamin, leaving more of it circulating until the kidneys filter it out. That said, this interaction is rated as insignificant for most people, and it tends to matter mainly at high aspirin doses taken over a long time. For the doses typically used in a combination product like this, you likely do not need to do anything extra, but your pharmacist is always a good person to check with if you have questions.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Aspirin, Butalbital, Caffeine
Insignificant DepletionBrand names include Fiorinal
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your immune cells and tissues depend on for repair and overall health. The aspirin in this combination may nudge your body to excrete a little more vitamin C through the urine, partly by reducing how well your cells hold onto it and possibly by slowing absorption from the gut a bit. That said, the evidence rates this as insignificant at the doses typically used in combination headache products, so most people do not need to worry or take a supplement. If you use aspirin regularly at higher doses over the long term, it's worth mentioning to your pharmacist or doctor just to be sure.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Aspirin, Butalbital, Caffeine, Codeine Phosphate
Insignificant DepletionBrand names include Fiorinal w/ Codeine
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your body needs for immune function, wound healing, and keeping tissues healthy. The aspirin in this combination product can interfere in two ways: it nudges your cells to take up less vitamin C and may also reduce how much is absorbed from your gut, so more ends up flushed out in the urine. That said, this effect is closely tied to dose, and at the lower amounts found in combination headache products, it is generally considered insignificant for most people. No supplement is needed for most patients, but if you have any concerns, a quick chat with your pharmacist is always a good idea.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Full nutrient report for Aspirin, Butalbital, Caffeine, Codeine Phosphate →
Aspirin, Butalbital, Caffeine, Phenacetin
Insignificant DepletionBrand names include Marnal
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your immune cells and tissues depend on to stay healthy, and aspirin, the active pain-relieving ingredient in this combination, can interfere with how well those cells hold onto it. At higher doses, aspirin appears to push more vitamin C out through the urine rather than letting tissues absorb and keep it. That said, the evidence rates this as insignificant for most people, so extra supplementation is not something the average patient needs to worry about with a standard dose. If you have any concerns, a quick chat with your pharmacist or doctor can help you figure out whether your specific situation calls for a closer look.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Full nutrient report for Aspirin, Butalbital, Caffeine, Phenacetin →
Aspirin, Caffeine
Insignificant DepletionBrand names include Anacin
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your immune cells and tissues depend on for repair and fighting off illness. Aspirin appears to interfere with how well those cells hold onto vitamin C, which can push more of it out through the urine rather than keeping it where the body needs it. That said, this interaction is rated insignificant at the low doses most people take for heart health, so the average person following a typical aspirin regimen does not need to worry about it. If you are on high-dose aspirin long-term for any reason, it is worth bringing up with your pharmacist or doctor.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Aspirin, Caffeine, Codeine Phosphate
Insignificant DepletionBrand names include Anacin w/ Codeine
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your body uses for immune defense, wound healing, and keeping tissues healthy. The aspirin in this combination may nudge your body to hold less of it, partly by slowing how well the gut absorbs it and partly by reducing how well certain cells take it up, which leaves more circulating in the blood where the kidneys can filter it out. That said, this effect appears to be dose-related, and at the lower doses found in combination pain products, the impact is considered insignificant for most people. No supplement is needed for the average person, but if you have any questions about your vitamin C intake, your pharmacist or doctor is a good place to start.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Full nutrient report for Aspirin, Caffeine, Codeine Phosphate →
Aspirin, Caffeine, Dihydrocodeine Bitartrate
Insignificant DepletionBrand names include Synalgos DC
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your immune cells and tissues depend on for repair and fighting off illness. Aspirin, the pain-relieving ingredient in this combination, appears to interfere with how well your cells hold onto vitamin C, which can push more of it out through the urine. That said, this effect is most relevant at high aspirin doses taken long-term, and the rating here is insignificant, meaning most people taking this product have nothing to worry about. If you have any concerns, your pharmacist or doctor can help you sort out whether your situation calls for any extra attention.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Full nutrient report for Aspirin, Caffeine, Dihydrocodeine Bitartrate →
Aspirin, Caffeine, Dover's Pwd
Insignificant DepletionBrand names include Acedoval, Dovacet
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your immune cells and tissues depend on to stay healthy, and aspirin has been shown to affect how well your body holds onto it. Specifically, aspirin appears to reduce how much vitamin C your white blood cells and tissues take in, which can leave more of it circulating in the bloodstream where the kidneys then filter it out through urine. Higher aspirin doses seem to have a bigger impact, but at the low doses commonly used for heart health, this effect is considered insignificant for most people. No supplement is needed for the typical patient, though if you have any concerns, your pharmacist or doctor is a good person to ask.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Aspirin, Caffeine, Hydrocodone
Insignificant DepletionBrand names include Damason-P
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your immune cells and tissues depend on, and here is an interesting quirk: aspirin appears to interfere with how your cells take up and hold onto vitamin C, which can push more of it out through the urine. It may also slightly reduce how much your gut absorbs in the first place. That said, this combination product contains a low dose of aspirin, and the evidence rates this interaction as insignificant for most people, so a supplement is not something most patients need to worry about. If you take high-dose aspirin regularly for another reason, it is worth mentioning to your pharmacist.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin
Insignificant DepletionBrand names include Lanorinal
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your immune cells and tissues depend on for repair and general health, and aspirin appears to interfere with how well those cells hold onto it. Specifically, aspirin seems to push vitamin C out of tissues and into the bloodstream, where the kidneys can filter it away in the urine, and at higher doses it may also reduce how much is absorbed from the gut in the first place. That said, this combination product contains a low dose of aspirin, and at that level the effect on vitamin C is considered insignificant for most people. If you have any concerns, a quick conversation with your pharmacist is always a reasonable step.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Full nutrient report for Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin →
Aspirin, Caffeine, Orphenadrine
Insignificant DepletionBrand names include Norgesic Forte, Invagesic, Invagesic Forte
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your immune cells and connective tissues depend on, and aspirin, the active pain reliever in this combination, can nudge your body to excrete more of it through the urine while also reducing how much gets absorbed in the gut. That said, this effect tends to be dose-related, meaning it matters most at high, long-term aspirin doses rather than the lower amounts typically found in combination products like this one. For most people, this is considered an insignificant depletion and no supplement is needed. If you take high-dose aspirin regularly or have concerns, it is worth a quick conversation with your pharmacist or doctor.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Aspirin, Caffeine, Phenacetin, Propoxyphene
Insignificant DepletionBrand names include Margesic Comp. 65
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your immune cells and tissues depend on to stay healthy, and aspirin appears to interfere with how well those tissues hold onto it. Specifically, aspirin can reduce the amount of vitamin C that your cells actually take in, so more of it ends up filtered out through the urine rather than being used. That said, this effect seems to matter mainly at high aspirin doses taken long-term, not at the low doses most people use for heart health. For typical aspirin use, most people do not need to worry about this or take a supplement, but if you have questions about your specific dose, a quick chat with your pharmacist is always a reasonable step.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Full nutrient report for Aspirin, Caffeine, Phenacetin, Propoxyphene →
Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide
Insignificant DepletionBrand names include Bufferin
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your body uses to support your immune system, heal tissue, and keep your cells healthy. At higher doses, aspirin appears to interfere with how well your cells hold onto vitamin C, causing more of it to spill out through the kidneys into urine. That said, this concern is mainly tied to high-dose aspirin taken over a long period. For the low doses most people take for heart health, this is considered insignificant, and a supplement is not needed for most people.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Full nutrient report for Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide →
Aspirin, Carisoprodol
Insignificant DepletionBrand names include Soma Compound
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your immune cells and connective tissue depend on every day. Here is the interesting part: aspirin appears to interfere with how certain cells take up and hold onto vitamin C, so more of it ends up circulating in the blood and eventually gets filtered out through the urine rather than staying where the body can use it. That said, this effect is rated insignificant, and it seems to matter mainly at high doses taken long-term. For most people using a standard low-dose aspirin, no extra vitamin C is needed, though it is always fine to mention your full medication list to your pharmacist if you have any concerns.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Aspirin, Carisoprodol, Codeine Phosphate
Insignificant DepletionBrand names include Soma Compound w/ Codeine
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Aspirin has a known interaction with vitamin C, which your body uses for immune function, tissue repair, and keeping blood vessels healthy. At higher doses, aspirin appears to interfere with how well your cells hold onto vitamin C, and some of it ends up being flushed out through the urine rather than staying where it is needed. That said, this combination uses a low aspirin dose, and at that level the effect is considered insignificant for most people. No supplement is typically needed, but if you are curious about your intake or take aspirin regularly, it is always fine to mention it to your pharmacist or doctor.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Full nutrient report for Aspirin, Carisoprodol, Codeine Phosphate →
Aspirin, Chlorpheniramine, Phenylpropanolamine
Insignificant DepletionBrand names include Alka-Seltzer Plus Cold
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your body relies on for immune function, skin repair, and keeping your cells healthy. Aspirin, the active ingredient here doing most of the work, appears to interfere with how your cells take up vitamin C, which can nudge more of it into the bloodstream where the kidneys filter it out through urine. That said, this effect is tied to higher doses of aspirin taken regularly, and the evidence rating for this combination is insignificant, meaning most people taking it do not need to worry or add a supplement. If you have any lingering questions, your pharmacist is a good first stop.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Full nutrient report for Aspirin, Chlorpheniramine, Phenylpropanolamine →
Aspirin, Citric Acid, Sodium Bicarbonate
Insignificant DepletionBrand names include Alka-Seltzer Pain Reliever and Antacid
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your immune cells and tissues depend on for repair and fighting off illness. Aspirin appears to interfere with how well your cells hold onto vitamin C, which can push more of it out through the urine, and at higher doses it may also reduce how much your gut absorbs. That said, this combination product uses a low amount of aspirin, and the evidence puts this depletion in the 'insignificant' category, meaning most people using it occasionally have nothing to worry about. If you take aspirin daily at higher doses long-term, it is worth a quick conversation with your pharmacist.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Full nutrient report for Aspirin, Citric Acid, Sodium Bicarbonate →
Aspirin, Codeine Phosphate
Insignificant DepletionBrand names include Aspirin w/ Codeine
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your immune cells and connective tissue depend on, and aspirin may nudge levels down slightly by reducing how well your cells hold onto it and, to some extent, how much your gut absorbs. The body responds by clearing more of it through urine. That said, this effect is really only a practical concern at high, long-term aspirin doses. At the lower doses commonly used for heart protection, most people do not need to take any extra vitamin C, though it is always fine to mention your full medication list to your pharmacist if you have questions.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Aspirin, Codeine Phosphate, Methocarbamol
Insignificant DepletionBrand names include Robaxisal C
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your immune cells and tissues depend on, and aspirin, at higher doses, can nudge your body toward flushing more of it out through urine rather than holding onto it. The short version: aspirin appears to reduce how well your cells take up vitamin C, so more of it ends up filtered out by the kidneys. That said, this interaction is rated insignificant for most people, especially those taking low-dose aspirin. No supplement is needed for the typical patient, but if you take higher doses of aspirin regularly over a long stretch of time, it is worth mentioning to your pharmacist or doctor.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Full nutrient report for Aspirin, Codeine Phosphate, Methocarbamol →
Aspirin, Codeine Phosphate, Phenobarbital
Insignificant DepletionBrand names include Phenaphen
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your body needs to support your immune system, heal tissues, and keep cells healthy. Aspirin, specifically at higher doses, can nudge your body to hold less of it in your cells and flush a bit more out through the urine, and it may also reduce how much you absorb from food. That said, the evidence rates this as insignificant for most people, especially those taking a low daily aspirin for heart health. If you happen to be on high-dose aspirin long-term, it is worth mentioning to your pharmacist or doctor just to be safe.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Full nutrient report for Aspirin, Codeine Phosphate, Phenobarbital →
Aspirin, Diphenhydramine, Phenylpropanolamine
Insignificant DepletionBrand names include Alka Seltzer Plus Night Time Effervescent
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your body uses to support your immune system, heal tissue, and keep cells healthy. Aspirin, at higher doses, appears to interfere with how your cells take up vitamin C, leaving more of it to spill out through the kidneys. That said, this combination product contains a low dose of aspirin, and at that level the effect on vitamin C is considered too small to matter for most people. No supplement is needed for the typical user, but if you have questions about your specific situation, your pharmacist or doctor is a good person to ask.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Full nutrient report for Aspirin, Diphenhydramine, Phenylpropanolamine →
Aspirin, Dipyridamole
Insignificant DepletionBrand names include Aggrenox, Asasantin Retard
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your immune cells and tissues depend on to function well, and aspirin appears to interfere with how those cells take it in, leaving more of it to spill out through the kidneys rather than being used. That said, this interaction is dose-dependent, meaning it becomes meaningful mainly at high aspirin doses taken long-term. At the low doses typically used for heart health, this is generally considered insignificant and most people do not need to do anything about it. If you have any concerns, your pharmacist or doctor can help you decide whether your situation warrants a closer look.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Aspirin, Ethoheptazine, Meprobamate
Insignificant DepletionBrand names include Equagesic
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Aspirin can interfere with how your body holds onto vitamin C, a nutrient your immune system and tissues need for repair and healing. At higher doses, aspirin appears to reduce how well cells absorb and keep vitamin C, so more of it ends up filtered out through the urine. That said, this combination product contains a relatively low aspirin dose, and the evidence rating here is insignificant, meaning most people taking it do not need a supplement. If you take aspirin regularly or have questions about your vitamin C levels, a quick conversation with your pharmacist or doctor can put your mind at ease.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Full nutrient report for Aspirin, Ethoheptazine, Meprobamate →
Aspirin, Hydrocodone
Insignificant DepletionBrand names include Alor 5 500, Lortab ASA
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your immune cells and connective tissue depend on, and aspirin has been shown to interfere with how well the body's cells hold onto it, leaving more of it to be filtered out through the kidneys. That said, this effect appears to be closely tied to high, long-term aspirin doses rather than the lower amounts most people take for heart health. For the typical aspirin user, this is considered an insignificant concern and supplementing is not something most people need to worry about. Still, if you have questions about your specific dose or situation, your pharmacist or doctor is the right person to ask.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Aspirin, Meprobamate
Insignificant DepletionBrand names include Micrainin
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your body depends on for immune defense, wound healing, and keeping tissues healthy. Regular-strength aspirin appears to interfere with how your cells take up vitamin C, and some of it ends up flushed out through the kidneys rather than staying where the body can use it. That said, this interaction is rated insignificant, meaning it really only becomes a practical concern for people taking very high doses of aspirin over a long period of time. If you are on a low-dose aspirin for your heart, most experts say there is nothing extra you need to do, but your pharmacist or doctor can give you personal guidance.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Aspirin, Methocarbamol
Insignificant DepletionBrand names include Robaxisal
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your body uses to support your immune system, heal tissue, and keep your cells healthy. High doses of aspirin can interfere with how your cells take up vitamin C, and may also reduce how much you absorb from food, leaving more of it to be flushed out through the kidneys. That said, this is rated as insignificant depletion, so for most people taking low-dose aspirin (like the 81 mg used for heart health), this is not a practical concern and supplements are generally not needed. If you are on long-term, high-dose aspirin for any reason, it is worth a quick conversation with your pharmacist or doctor.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Aspirin, Oxycodone
Insignificant DepletionBrand names include Percodan
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your immune cells and tissues depend on for repair and fighting off illness. Aspirin, even at modest doses, can nudge your body's cells to take up slightly less vitamin C, leaving a bit more to spill out through the kidneys. That said, this interaction is rated insignificant, meaning it is not considered a real concern for most people, especially those on the low doses commonly used for heart health. If you take high-dose aspirin regularly and have questions, it is worth a quick chat with your pharmacist.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Aspirin, Pentazocine
Insignificant DepletionBrand names include Talwin Compound
Aspirin reduces tissue and leukocyte uptake of vitamin C, leaving more in the plasma to be filtered into the urine and increasing elimination. It may also reduce absorption of vitamin C from the gut. These effects are dose-related. Vitamin C supplementation has been suggested for people taking high-dose aspirin long-term. Supplements aren't needed with the low doses of aspirin used for cardiovascular indications.
Vitamin C is something your body relies on for healing, immune function, and keeping tissues healthy. Aspirin appears to interfere with how well your cells hold onto vitamin C, and at higher doses it may also reduce how much is absorbed from the gut, with both effects being dose-related. That said, the evidence rates this as insignificant for most people, especially those taking a low daily aspirin for heart health. If you take higher doses of aspirin long-term and have questions about your vitamin C levels, it is worth a quick conversation with your pharmacist or doctor.
References (5)
- Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45. DOI
- Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. PubMed
- Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. PubMed
- Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90.
- Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204.
Atenolol, Chlortalidone
Insignificant DepletionBrand names include AtenixCo, Totaretic, Tenoret 50
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and tissue repair all count on, so it is worth knowing that chlortalidone, a diuretic in this combination, can cause the kidneys to flush out more water than usual, and vitamin C may leave the body along with it. That said, this effect looks to be quite small in practice, and significant vitamin C depletion has not been reported with everyday oral use of diuretics like this one. For most people taking this medication, no extra vitamin C is needed, though if you have any concerns it is always fine to bring them up with your pharmacist or doctor.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Atenolol, Chlorthalidone
Insignificant DepletionBrand names include Tenoretic
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Chlorthalidone is a diuretic, meaning it helps your body shed excess fluid through urine, and that extra flushing could theoretically carry some vitamin C out along with it. Vitamin C is something your immune system, skin, and blood vessels depend on every day. That said, real-world evidence has not shown meaningful vitamin C losses with oral diuretics like this one, which is why the rating here is insignificant. For most people taking this combination, no extra vitamin C is needed, but if you have questions or eat a very limited diet, it is worth a quick chat with your pharmacist.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Azilsartan, Chlorthalidone
Insignificant DepletionBrand names include Edarbyclor
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and blood vessels depend on every day. Chlorthalidone is a diuretic, meaning it helps your kidneys remove extra fluid, and that process can carry a small amount of vitamin C out in the urine along with it. That said, this interaction is rated insignificant, and meaningful vitamin C loss has not been reported with regular oral use of diuretics like this one. Most people taking this combination do not need a supplement, but if you have questions or eat a diet low in fruits and vegetables, it is worth a quick conversation with your pharmacist.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Bazedoxifene Acetate, Conjugated Estrogens
Insignificant DepletionBrand names include Duavee
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your body needs for immune function, skin repair, and protecting cells from damage. The estrogen component in this medication has been loosely linked to slightly lower vitamin C levels, possibly because the body uses vitamin C to help process estrogen in tissues, or because estrogen may affect how well vitamin C is absorbed. That said, the evidence here is mixed and the rating is insignificant, meaning this is not a real concern for most people who eat a reasonably balanced diet. If you have questions about your vitamin C intake, your pharmacist or doctor is a good place to start.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Full nutrient report for Bazedoxifene Acetate, Conjugated Estrogens →
Benazepril, Hydrochlorothiazide
Insignificant DepletionBrand names include Lotensin HCT
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and blood vessels all depend on, so it makes sense to wonder about it. The hydrochlorothiazide portion of this combination is a diuretic, meaning it makes your kidneys produce more urine, and there is some thinking that extra urine output could carry a little more vitamin C out of the body. That said, meaningful vitamin C depletion has not actually been reported with regular oral use of diuretics like this one. For most people taking this medication, no special action is needed, but if you have questions about your diet or vitamins, your pharmacist or doctor is a good person to ask.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Bendroflumethiazide
Insignificant DepletionBrand names include Naturetin, Aprinox, Neo-NaClex
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it makes sense to wonder if bendroflumethiazide affects it. Because this thiazide diuretic makes your kidneys pass more water, there is a theoretical chance that some vitamin C gets flushed out along with it. That said, real-world studies have not found meaningful vitamin C losses with regular oral use of diuretics like this one, and for most people taking bendroflumethiazide no extra vitamin C is needed. If you have any concerns, a quick chat with your pharmacist or doctor can give you peace of mind.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Bendroflumethiazide, Nadolol
Insignificant DepletionBrand names include Corzide
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it is worth knowing that diuretics like bendroflumethiazide can, in theory, carry a little extra vitamin C out of the body along with the extra water they help you shed through urine. That said, meaningful vitamin C depletion has not been reported with regular oral use of diuretics, and this interaction is rated as insignificant for most patients. No action is needed for the average person on this combination, but if you have questions or eat a diet low in fruits and vegetables, a quick chat with your pharmacist is always a reasonable idea.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Bendroflumethiazide, Potassium
Insignificant DepletionBrand names include Neo-NaClex-K, Centyl K
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and wound healing all depend on, so it is worth understanding how your water pill fits in. Bendroflumethiazide works by making your kidneys pass more water and salt out through urine, and there is some thought that this extra water loss could carry a little vitamin C along with it. That said, meaningful vitamin C depletion has not been reported with regular oral use of diuretics like this one, and the evidence here is rated insignificant. For most people taking bendroflumethiazide, no special action is needed, but mention it to your pharmacist or doctor if you have any concerns.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Bendroflumethiazide, Rauwolfia Serpentina
Insignificant DepletionBrand names include Rauzide
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and blood vessels all depend on, so it is worth knowing that thiazide diuretics like bendroflumethiazide can theoretically nudge levels down a little by increasing the amount of water your kidneys flush out, which may carry small amounts of vitamin C along with it. That said, meaningful depletion has not been reported with regular oral use of this type of medicine, and the evidence here is rated insignificant. For most people taking this combination, there is no reason to worry or to start a supplement, but if you have questions about your diet or vitamin levels, your pharmacist or doctor is a great person to ask.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Full nutrient report for Bendroflumethiazide, Rauwolfia Serpentina →
Benzthiazide
Insignificant DepletionBrand names include Exna
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it's a nutrient worth knowing about. Benzthiazide is a diuretic, meaning it nudges your kidneys to flush out more water and salt, and some research suggests that extra water loss can carry a little vitamin C out with it through the urine. That said, this has been rated insignificant, and meaningful vitamin C depletion has not been reported with regular oral use of diuretics like this one. Most people taking benzthiazide do not need to do anything differently, but if you have questions about your diet or any supplements, your pharmacist or doctor is a great person to ask.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Bisoprolol, Hydrochlorothiazide
Insignificant DepletionBrand names include Ziac
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and blood vessels count on every day. The hydrochlorothiazide in this combination is a diuretic, meaning it makes your kidneys pass more water, and there is some thought that this extra fluid loss could carry a little vitamin C out with it. That said, this is rated as insignificant, and real deficiency has not been reported with regular use of diuretics taken by mouth. Most people on this medication do not need to do anything special, but if you have questions about your diet or vitamin intake, your pharmacist or doctor is a great place to start.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Bumetanide
Insignificant DepletionBrand names include Burinex
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and wound healing all depend on, so it's worth knowing that loop diuretics like bumetanide could nudge urinary losses slightly upward, likely because they push the kidneys to move more water out and vitamin C goes along for the ride. That said, real-world vitamin C depletion from oral diuretics like bumetanide simply hasn't shown up in the evidence, and this interaction is rated insignificant. For most people taking bumetanide, no extra vitamin C is needed, but if you have questions about your diet or any symptoms you're noticing, your pharmacist or doctor is a great place to start.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Bumetanide, Potassium
Insignificant DepletionBrand names include Burinex K
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something the body needs to support the immune system, heal wounds, and keep connective tissue strong. Bumetanide, like other loop diuretics, makes the kidneys produce more urine, and there is some thought that extra fluid leaving the body could carry a little vitamin C along with it. That said, meaningful vitamin C depletion has not been reported with regular oral use of diuretics like this one, so most people taking bumetanide do not need to worry or add a supplement. If you have any concerns, your pharmacist or doctor can help you sort out whether your diet is giving you enough.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Caffeine, Potassium Salicylate, Salicylamide
Insignificant DepletionBrand names include Trim-Elim
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your body uses to support your immune system, heal tissue, and keep your cells healthy. There is some thought that diuretic-type effects could nudge the kidneys to flush out a little more vitamin C in the urine along with extra water, but this has only been shown with high intravenous doses of certain diuretics, not with typical oral use. For this combination product, the evidence rating is insignificant, meaning real-world depletion has not been a documented concern. Most people taking this do not need to do anything, but if you have questions about your vitamin C intake, your pharmacist or doctor is a good person to ask.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Full nutrient report for Caffeine, Potassium Salicylate, Salicylamide →
Candesartan Cilexetil, Hydrochlorothiazide
Insignificant DepletionBrand names include Atacand HCT
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and blood vessels all depend on, so it is worth knowing that the hydrochlorothiazide in this combination may nudge levels slightly lower. Because it is a diuretic, it causes the kidneys to push out more water, and a small amount of vitamin C can tag along with that extra fluid. In practice, this effect appears to be minor and real deficiency has not been reported with regular oral use of diuretics like this one. Most people on this medication do not need to take any action, but if you have concerns, a quick conversation with your pharmacist or doctor can put your mind at ease.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Full nutrient report for Candesartan Cilexetil, Hydrochlorothiazide →
Captopril, Hydrochlorothiazide
Insignificant DepletionBrand names include Capozide, Acezide
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and blood vessels all depend on, so it is worth knowing that diuretics like hydrochlorothiazide can sometimes increase how much your body flushes out in urine, simply because they push more water through the kidneys. That said, this has been rated as an insignificant depletion, meaning meaningful vitamin C loss from long-term oral use of these medications has not really been documented in practice. For most people taking this combination, no extra action is needed, but if you are curious whether your diet is giving you enough, your pharmacist or doctor is a good person to ask.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Chlorothiazide
Insignificant DepletionBrand names include Diuril
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and wound healing all depend on, so it is worth knowing that diuretics like chlorothiazide can, in theory, cause a little more of it to leave the body through urine along with the extra water these medications flush out. That said, meaningful vitamin C depletion has not been reported with everyday oral use of this type of diuretic, and the evidence here is rated insignificant, meaning most people taking chlorothiazide do not need to worry about this or take a supplement for it. If you have any concerns, your pharmacist or doctor can help you figure out whether your diet is giving you plenty.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Chlorothiazide, Methyldopa
Insignificant DepletionBrand names include Aldoclor 150, Aldochlor, Aldoclor 250
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and blood vessels all count on to stay healthy. Thiazide diuretics like chlorothiazide work by making your kidneys push out more water and salt, and there is some thought that extra water loss could carry a little vitamin C out with it. That said, this effect has not been shown to cause a real shortage with everyday oral use, and for most people taking these medications a supplement is not needed. If you are still curious, a quick chat with your pharmacist can put your mind at ease.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Chlorothiazide, Reserpine
Insignificant DepletionBrand names include Diupres
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and blood vessels all depend on, so it is worth knowing that diuretics like chlorothiazide may nudge levels slightly lower by increasing how much water your kidneys flush out, and water-soluble vitamins like vitamin C can tag along with that extra fluid loss. That said, this interaction is rated insignificant, and meaningful vitamin C depletion has not been reported with everyday oral use of diuretics. Most people on this combination do not need to take any action, but if you have concerns about your diet or nutrient levels, your pharmacist or doctor is a great place to start that conversation.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Chlorthalidone
Insignificant DepletionBrand names include Hygroton, Thalitone
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and tissues depend on to stay healthy and repair themselves. Because chlorthalidone is a diuretic that makes your kidneys produce more urine, there is a theoretical possibility that some vitamin C gets carried out with that extra fluid. In practice, though, meaningful vitamin C loss from long-term use of diuretics like chlorthalidone has not been reported, and this is rated as insignificant. Most people taking this medication do not need to do anything about it, but if you have concerns, a quick conversation with your pharmacist is always a reasonable step.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Chlorthalidone, Clonidine
Insignificant DepletionBrand names include Clorpres, Combipres
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and blood vessels all count on every day. Because chlorthalidone is a diuretic, it makes the kidneys pass more water, and some research suggests that extra fluid loss could carry a small amount of vitamin C out with it. That said, this has only been seen with intravenous doses in specific situations, and meaningful vitamin C depletion has not been reported with regular long-term use of oral diuretics like chlorthalidone. For most people taking this combination, no special action is needed, but mention it to your pharmacist or doctor if you have any concerns.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Conjugated Estrogens
Insignificant DepletionBrand names include Premarin, Cenestin, Enjuvia
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your immune system, skin, and tissues depend on every day, and there is some research suggesting that estrogens like conjugated estrogens may slightly reduce how well your body absorbs it or speed up how quickly it gets used up. That said, the evidence here is genuinely mixed, and this is rated as insignificant for most people. If you are eating a reasonable amount of fruits and vegetables, you are very likely getting plenty. No supplement is needed for most patients, but if you have concerns about your diet, your pharmacist or doctor is a good person to ask.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Conjugated Estrogens, Medroxyprogesterone Acetate
Insignificant DepletionBrand names include Prempro, Premplus
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it matters to keep your levels steady. There is some research suggesting that estrogen hormones like those in this medication may slightly reduce how well the body absorbs vitamin C or may use it up a bit faster as the body processes estrogen. That said, the evidence here is mixed and the overall impact is rated as insignificant, meaning that for most people eating a reasonably balanced diet, this is not a concern worth worrying about. If your diet is very low in fruits and vegetables, it is worth a quick conversation with your pharmacist or doctor.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Full nutrient report for Conjugated Estrogens, Medroxyprogesterone Acetate →
Conjugated Estrogens, Meprobamate
Insignificant DepletionBrand names include PMB 200, PMB 400
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your immune system, skin, and tissue repair all count on, and there is some research suggesting estrogens like conjugated estrogens might interfere with it, either by slowing how much your gut absorbs or by using it up faster as the body processes the hormone. That said, the evidence here is genuinely mixed and the overall impact is rated insignificant for most people. If you are eating a reasonable amount of fruits and vegetables, you very likely do not need to worry about this. If you have concerns about your diet or vitamin levels, your pharmacist or doctor is a great person to ask.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Full nutrient report for Conjugated Estrogens, Meprobamate →
Conjugated Estrogens, Methyltestosterone
Insignificant DepletionBrand names include Premarin with Methyltestosterone
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your body uses to support immune function, skin health, and tissue repair, so keeping levels in a good range matters. Some research suggests estrogens may slightly reduce how well vitamin C is absorbed in the gut or may cause the body to use it up a bit faster, possibly because vitamin C helps neutralize estrogen byproducts in tissues. That said, the evidence here is mixed and the overall effect is rated as insignificant for most people. If you eat a reasonably varied diet with fruits and vegetables, you are unlikely to need a supplement, but your pharmacist or doctor can give you personal guidance if you have concerns.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Full nutrient report for Conjugated Estrogens, Methyltestosterone →
Cryptenamine, Methyclothiazide
Insignificant DepletionBrand names include Diutensen
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and blood vessels all depend on, so it is worth knowing that diuretics like methyclothiazide can sometimes nudge your body to flush a little more of it out through urine along with extra water. That said, meaningful vitamin C depletion from oral diuretics has not really shown up in clinical use, and the evidence here is rated insignificant. For most people taking this medication, no extra vitamin C is needed, but if you have any concerns your pharmacist is a good first stop.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Cyclothiazide
Insignificant DepletionBrand names include Fluidil, Anhydron
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and wound healing all depend on, so it is worth understanding when a medication might affect it. Cyclothiazide is a thiazide diuretic, meaning it helps your kidneys push out extra fluid, and that extra urine flow can theoretically carry a little vitamin C out with it. That said, this interaction is rated as insignificant, and meaningful vitamin C depletion has not been reported with regular oral use of diuretics like this one. Most people taking cyclothiazide do not need to do anything about this, but if you have concerns, your pharmacist or doctor is a good person to ask.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Cyproterone Acetate, Ethinyl Estradiol
Insignificant DepletionBrand names include Diane-35, Dianette
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is a nutrient your body uses for immune defense, skin repair, and acting as an antioxidant. The estrogen component of this medication may modestly affect vitamin C by slightly reducing how much your gut absorbs or by using some of it up as the body processes estrogen in tissue. That said, the research here is mixed and the effect is rated insignificant, meaning that if you eat a reasonable variety of fruits and vegetables, this is very unlikely to matter for you. No supplement is needed for most people, but if you have concerns about your diet, a quick chat with your pharmacist is always a good idea.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Full nutrient report for Cyproterone Acetate, Ethinyl Estradiol →
Deserpidine, Hydrochlorothiazide
Insignificant DepletionBrand names include Oreticyl Forte, Oreticyl
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and wound healing all depend on, so it is worth knowing that diuretics like hydrochlorothiazide can cause the kidneys to flush out a bit more of it along with extra water. That said, meaningful vitamin C depletion from oral diuretics has not been reported in practice, and the evidence for this combination is rated insignificant. Most people taking this medication do not need to do anything differently, but if you have questions about your diet or whether a supplement makes sense for you, your pharmacist or doctor is a good person to ask.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Deserpidine, Methyclothiazide
Insignificant DepletionBrand names include Enduronyl Forte, Enduronyl
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it is worth knowing that diuretics like methyclothiazide can, in theory, cause a little extra vitamin C to leave the body through the urine when water excretion goes up. That said, meaningful vitamin C depletion has not been reported with long-term use of oral diuretics, and this interaction is rated insignificant. For most people taking this medication, no special action is needed, though you are always welcome to mention it to your pharmacist if you have questions.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Desogestrel, Ethinyl Estradiol
Insignificant DepletionBrand names include Ortho-Cept 28, Ortho-Cept 21, Marvelon 21
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it is worth understanding this one. The estrogen component of this birth control pill may slightly reduce how well your body absorbs vitamin C or speed up how your body uses it up, partly because vitamin C appears to help protect estrogen from breaking down in tissue. That said, the research on this is genuinely mixed, and the overall effect is considered insignificant for most people who eat a reasonably balanced diet. If you are concerned about your vitamin C intake, a quick chat with your pharmacist or doctor can put your mind at ease.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Drospirenone, Estetrol
Insignificant DepletionBrand names include Nextstellis
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it matters to keep your levels in a good range. Some research suggests estrogen-containing medications like this one might nudge vitamin C levels down a little, possibly because estrogen tissue metabolism uses up some vitamin C as an antioxidant, or slightly reduces how much you absorb. That said, the evidence here is mixed and the effect is considered insignificant for most people eating a reasonably balanced diet. If you eat fruits and vegetables regularly, there is nothing special you need to do, but if you have concerns about your diet, a quick chat with your pharmacist or doctor can put your mind at ease.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Drospirenone, Ethinyl Estradiol
Insignificant DepletionBrand names include Yasmin, Gianvi, Angeliq
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your body uses for immune defense, skin repair, and general antioxidant protection. Birth control pills containing estrogen like this one have shown some conflicting signals around vitamin C levels, with the thought being that estrogen may compete with vitamin C during absorption or that the body uses vitamin C to help break down estrogen in tissue. That said, the evidence is inconsistent and the rating here is insignificant, meaning this is not a practical concern for most people who eat a reasonably varied diet. If your diet is already low in fruits and vegetables, it is worth mentioning to your pharmacist or doctor just to be sure.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
drospirenone, ethinyl estradiol, levomefolate
Insignificant DepletionBrand names include Beyaz
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your body uses for immune defense, skin health, and protecting cells from damage. The estrogen component of this birth control pill may slightly affect how your body absorbs or breaks down vitamin C, and there is some thought that vitamin C gets used up helping to process estrogen in body tissues. That said, the research here is mixed, and for most people eating a reasonably balanced diet, this is not considered a meaningful concern. No supplement is recommended for this, but if you have questions about your diet or vitamin C intake, your pharmacist or doctor is a good person to ask.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Full nutrient report for drospirenone, ethinyl estradiol, levomefolate →
Enalapril Maleate, Hydrochlorothiazide
Insignificant DepletionBrand names include Vaseretic
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and blood vessels all depend on, so it is worth knowing that the hydrochlorothiazide in this combination pill is a diuretic, meaning it makes your kidneys produce more urine. That extra urine output can carry a small amount of vitamin C out with it. In practice, though, meaningful vitamin C depletion has not been reported with long-term use of oral diuretics like this one, and most people taking this medication do not need a supplement for this reason. If you have any concerns, your pharmacist or doctor is a good person to ask.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Full nutrient report for Enalapril Maleate, Hydrochlorothiazide →
Esterified Estrogens
Insignificant DepletionBrand names include Menest, Estratab
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your body uses to support immune function, skin health, and tissue repair, and there is some suggestion that estrogen-based medications like esterified estrogens may slightly affect how the body absorbs or breaks it down. The research here is genuinely mixed, though, and this is rated as insignificant depletion, meaning it is unlikely to be a real concern for someone who eats a reasonably varied diet. If your vitamin C intake is already very low, it may be worth a quick conversation with your pharmacist or doctor, but for most people no supplement is needed.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Esterified Estrogens, Methyltestosterone
Insignificant DepletionBrand names include Estratest
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your body uses to support immune function, skin, and tissue repair, and there is some thought that estrogen-containing medications might slightly affect how the body absorbs or breaks it down. The research here is genuinely mixed, though, and this combination is rated as an insignificant depletion, meaning it really only comes up as a concern for people who are already eating very little vitamin C. If your diet regularly includes fruits and vegetables, you most likely have nothing to worry about, but feel free to ask your pharmacist if you have questions about your intake.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Full nutrient report for Esterified Estrogens, Methyltestosterone →
Estradiol
Insignificant DepletionBrand names include Estrace, Gynodiol, Vagifem
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your immune system, skin, and tissue repair all depend on, and there is some research suggesting estradiol might nudge levels down a little, possibly because the body uses vitamin C to help break down estrogen, or because absorption is slightly affected. That said, the evidence here is genuinely mixed and the overall rating is insignificant, meaning this is not a concern for most people taking estradiol who already eat a reasonable amount of fruits and vegetables. If your diet is very low in vitamin C, it is worth mentioning to your pharmacist or doctor, but supplements are not something most people on estradiol need to worry about for this reason.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Estradiol, Medroxyprogesterone
Insignificant DepletionBrand names include Divitren
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your immune system, skin, and tissues depend on every day. There is some research suggesting that estrogens like estradiol may nudge vitamin C levels slightly lower, possibly because the body uses vitamin C to help break down estrogen in tissues, or because absorption from the gut is mildly affected. That said, the evidence is genuinely mixed and this is rated as insignificant for most people. If you eat a reasonable amount of fruits and vegetables, you likely have nothing to worry about, but feel free to mention it to your pharmacist if you have concerns about your diet.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Estradiol, Norethindrone Acetate
Insignificant DepletionBrand names include Activella
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it is worth knowing that estrogen-containing medications like this one have been loosely linked to slightly lower vitamin C levels in some studies. The thinking is that estrogens may slow how well vitamin C is absorbed in the gut, speed up how the body breaks it down, or use up vitamin C stores to protect the estrogen itself from oxidation in body tissues. That said, the research is conflicting, the rating here is insignificant, and most people eating a reasonably balanced diet are unlikely to have any real concern. If your diet is already low in fruits and vegetables, it is worth mentioning to your pharmacist or doctor just to be sure.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Estradiol, Norgestimate
Insignificant DepletionBrand names include Ortho-Prefest
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your body uses to support immune function, skin health, and tissue repair, so keeping your levels up matters in general. There is some research suggesting estrogens like estradiol may slightly reduce how well the body absorbs vitamin C or may use it up a bit faster as part of normal hormone processing, but the evidence on this is genuinely mixed. For most people taking this medication who eat a reasonable amount of fruits and vegetables, this is not a practical concern. If your diet is low in vitamin C, it is worth mentioning to your pharmacist or doctor.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Estradiol, Progesterone
Insignificant DepletionBrand names include Bijuvanda
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your body uses for immune defense, skin repair, and keeping cells protected from damage. There is some research suggesting estrogens like estradiol may slightly lower vitamin C, possibly because the body uses vitamin C to help process estrogen in tissues, or because absorption may be mildly affected. The evidence here is mixed and the rating is insignificant, meaning if you eat a reasonable amount of fruits and vegetables, this is very unlikely to be a concern for you. No supplement is typically needed, but if you have questions about your diet, your pharmacist or doctor is a good person to ask.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Estrogen
Insignificant DepletionEvidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your body uses to support your immune system, skin, and tissue repair, and there is some research suggesting estrogen may slightly reduce how well you absorb it or speed up how your body uses it up. That said, the evidence here is genuinely mixed, and for most people eating a reasonable diet, this is not something to worry about. Supplements are not considered necessary unless your vitamin C intake is already quite low. If you have concerns, a quick chat with your pharmacist or doctor can help you figure out if your diet has you covered.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Estrone
Insignificant DepletionBrand names include Ortho-Est
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your body uses to protect cells, heal tissue, and support your immune system, so having enough of it matters. Estrone, like other estrogens, may use up some of that vitamin C in the body's own process of keeping the hormone stable, and there is some suggestion it could affect how well vitamin C is absorbed or broken down. That said, the research here is mixed and the overall effect is considered insignificant for most people, meaning if you eat a reasonably balanced diet you are very likely getting plenty. If you are concerned, a quick chat with your pharmacist or doctor can put your mind at ease.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Estropipate
Insignificant DepletionBrand names include Ogen, Ortho EST
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it matters to keep your levels steady. With estrogen-based medications like estropipate, there is some suggestion that estrogen may slightly reduce how well the body absorbs vitamin C or use up more of it in tissue, but the research on this is mixed and not conclusive. The good news is that for most people eating a reasonable diet, this is not considered a meaningful concern. If you are worried about your intake, a quick conversation with your pharmacist or doctor can put your mind at ease.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Ethacrynic Acid
Insignificant DepletionBrand names include Edecrin
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and blood vessels all depend on, so it is worth knowing that loop diuretics like ethacrynic acid can pull extra water out through the kidneys, and a small amount of vitamin C may leave the body along with that extra urine. That said, meaningful vitamin C depletion has not been reported with long-term oral use of this type of medication, and a supplement is not considered necessary for most people taking it. If you have any concerns, a quick conversation with your pharmacist or doctor can put your mind at ease.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Ethanol
Insignificant DepletionPreliminary clinical evidence suggests that alcohol intake increases urinary excretion of vitamin C by 47%. In healthy patients, this increased excretion does not appear to significantly affect vitamin C status. However, in chronic alcohol abusers, particularly those who are acutely unwell or critically ill, vitamin C deficiency is common and scurvy can occur.
Vitamin C is something your body needs to heal wounds, support your immune system, and keep connective tissue strong. Alcohol can nudge the kidneys to flush out more vitamin C in the urine than usual, so some of it gets lost before the body can use it. For most people who drink occasionally or even moderately, this does not appear to meaningfully affect vitamin C levels. That said, people who drink heavily over a long period of time are in a different situation, and if that applies to you, it is worth having a conversation with your pharmacist or doctor.
References (3)
- Faizallah R, Morris AI, Krasner N, Walker RJ. Alcohol enhances vitamin C excretion in the urine. Alcohol and Alcoholism. 1986;21(1):81-84. DOI
- Goodwin JS, Sanchez CJ, Thomas P, et al. Alcohol intake in a healthy elderly population. Am J Public Health. 1987;77(2):173-7. PubMed
- Ong J, Randhawa R. Scurvy in an alcoholic patient treated with intravenous vitamins. BMJ Case Rep. 2014;2014. PubMed
Ethiny Estradiol, Levonorgestrel
Insignificant DepletionBrand names include Logynon, Microgynon 30 ED
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it is worth understanding this connection. Some research suggests estrogen-containing pills like this one may interfere slightly with how the body absorbs vitamin C or how quickly it gets used up in tissues, though the studies on this are mixed and not definitive. Because the evidence is conflicting and the overall effect appears small, most people taking this contraceptive who eat a reasonably balanced diet do not need to worry or take a supplement. If your diet is already low in fruits and vegetables, it is worth a quick chat with your pharmacist or doctor just to check.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Ethinyl Estradiol
Insignificant DepletionBrand names include Estinyl
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your body uses for immunity, skin repair, and keeping your cells protected from damage. There is some research suggesting that estrogen-based medications like ethinyl estradiol might slightly reduce vitamin C levels, possibly because the body uses vitamin C to help process estrogen in tissues, or because absorption is mildly affected. The evidence here is conflicting and the overall rating is insignificant, meaning that for most people eating a reasonably balanced diet, this is not a concern worth worrying about. If you are unsure whether your vitamin C intake is adequate, a quick conversation with your pharmacist or doctor can put your mind at ease.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Ethinyl Estradiol, Desogestrel
Insignificant DepletionBrand names include Linessa, Apri, Reclipsen
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it's worth knowing that estrogen-containing birth control like this one has been loosely linked to lower vitamin C levels in some studies. The thinking is that estrogens may reduce how well the gut absorbs vitamin C, or that the body uses up more of it to help process estrogen in the tissues. That said, the research is genuinely mixed, and this is rated as an insignificant depletion, meaning most people taking this pill who eat a reasonably balanced diet have nothing to worry about. If your diet is low in fruits and vegetables, it's worth mentioning to your pharmacist or doctor just to be safe.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Ethinyl Estradiol, Drospirenone
Insignificant DepletionBrand names include Yaz
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it makes sense to keep an eye on it. Some research suggests estrogen-containing pills like this one may nudge vitamin C levels down a bit, possibly because estrogen speeds up how the body breaks down vitamin C or because the body uses vitamin C to help process estrogen in tissues. That said, the evidence here is genuinely mixed and the overall rating is insignificant, meaning most people on this pill who eat a reasonably balanced diet have nothing to worry about. If your diet is already low in fruits and vegetables, it is worth mentioning to your pharmacist or doctor.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Ethinyl Estradiol, Ethynodiol Diacetate
Insignificant DepletionBrand names include Demulen 1/35, Zovia 1/35, Demulen Compack
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your body uses to support immune function, skin health, and protecting cells from damage. This oral contraceptive contains estrogen, and estrogen may slightly affect vitamin C by reducing how well it's absorbed in the gut or by using it up more quickly as the body works to break estrogen down in tissue. That said, the evidence here is mixed and the overall effect is considered insignificant for most people. If you eat a reasonably balanced diet with fruits and vegetables, you likely have nothing to worry about, but feel free to mention it to your pharmacist or doctor if you have concerns about your intake.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Full nutrient report for Ethinyl Estradiol, Ethynodiol Diacetate →
Ethinyl estradiol, Levonogestrel
Insignificant DepletionBrand names include Lybrel
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it matters to keep levels steady. The estrogen component of this birth control pill may slightly reduce how much vitamin C your body absorbs or speed up how quickly it breaks down, and some research suggests your body may also use vitamin C to help process estrogen itself. That said, the evidence here is mixed and the rating is insignificant, meaning this is not a concern for most people who eat a reasonably balanced diet. If your vitamin C intake is already very low, it's worth a quick conversation with your pharmacist or doctor.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Ethinyl Estradiol, Levonorgestrel
Insignificant DepletionBrand names include Levlite 28, Tri-Levlen 21, Tri-Levlen 28
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your body relies on for immune defense, skin repair, and protecting cells from damage. The estrogen in this birth control pill may slightly reduce how much vitamin C your body absorbs or how quickly it gets broken down, though research on this has been mixed and the effect appears quite small. For most people eating a reasonably balanced diet, this is not a concern worth worrying about. If you are already eating very little vitamin C, it is worth mentioning to your pharmacist or doctor.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Full nutrient report for Ethinyl Estradiol, Levonorgestrel →
Ethinyl Estradiol, Norethindrone
Insignificant DepletionBrand names include Femhrt, Loestrin 21, Ovcon 35 21
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your body relies on for immune defense, skin repair, and acting as an antioxidant. There is some research suggesting that estrogen, one of the hormones in this birth control pill, might slightly reduce how much vitamin C your body absorbs or how quickly it gets used up in tissues, but the studies on this have been mixed and inconclusive. For most people taking this pill who eat a reasonably varied diet, this is not something to worry about. If your diet is low in fruits and vegetables, it is worth mentioning to your pharmacist or doctor.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Ethinyl Estradiol, Norethindrone, Ferrous Fumarate
Insignificant DepletionBrand names include Estrostep Fe, Loestrin Fe, Microgestin FE
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your body uses to support your immune system, skin, and tissue repair, and there is some research suggesting that estrogen-containing medications like this one might affect how the body absorbs or uses it. The thinking is that the body may use up some vitamin C to help process estrogen in tissues, or that absorption could be slightly reduced. That said, the evidence here is mixed and the overall rating is insignificant, meaning most people eating a reasonably balanced diet are unlikely to have any problem. If you are concerned about your vitamin C intake, a quick conversation with your pharmacist or doctor can help you figure out whether anything needs to change.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Full nutrient report for Ethinyl Estradiol, Norethindrone, Ferrous Fumarate →
Ethinyl Estradiol, Norgestimate
Insignificant DepletionBrand names include Ortho Tri-Cyclen 28, Ortho Tri-Cyclen Lo, Ortho-Cyclen
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it is worth knowing that estrogen-containing birth control pills like this one have been loosely linked to lower vitamin C levels in some studies. The leading theories are that estrogen may slightly reduce how well vitamin C is absorbed in the gut, speed up how the body breaks it down, or use it up as the body tries to protect estrogen from oxidation in tissue. That said, the research is genuinely mixed, and for someone eating a reasonably balanced diet, this is rated as insignificant, meaning most people on this pill do not need a supplement. If you are concerned about your diet or want to double-check, a quick conversation with your pharmacist is all it takes.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Ethinyl Estradiol, Norgestrel
Insignificant DepletionBrand names include Ovral, Lo/Ovral, Cryselle
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it is worth knowing that estrogen-containing birth control pills like this one have been loosely linked to lower vitamin C levels in some studies. The leading theories are that estrogens may slow how well your gut absorbs vitamin C or speed up how quickly your body breaks it down, and some research also suggests your body uses vitamin C to help process estrogen in your tissues. That said, the evidence is genuinely mixed and this is rated as an insignificant depletion, meaning most people eating a reasonably balanced diet have nothing to worry about. If your vitamin C intake is already quite low, it is worth a quick chat with your pharmacist or doctor.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Etonogestrel, Ethinyl Estradiol
Insignificant DepletionBrand names include NuvaRing
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your body relies on for immune defense, wound healing, and protecting cells from damage. The estrogen component of this birth control ring may interact with vitamin C in a couple of ways: research suggests estrogen could reduce how well the gut absorbs it, speed up how the body breaks it down, or even use vitamin C up as the body processes estrogen in tissues. That said, the evidence is genuinely mixed and this is rated as insignificant for most people, meaning if you eat a reasonable amount of fruits and vegetables, there is likely nothing to worry about. If your diet is low in vitamin C, it is worth mentioning to your pharmacist or doctor.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Fosinopril, Hydrochlorothiazide
Insignificant DepletionBrand names include Monopril HCT
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is a nutrient your immune system, skin, and blood vessels depend on, and there is some early evidence that diuretics like hydrochlorothiazide may nudge the kidneys to excrete a little more of it along with extra fluid. That said, meaningful vitamin C depletion has not been reported with long-term use of oral diuretics, so this is rated insignificant for most people. No routine supplementation is needed, but if you have any concerns, a quick conversation with your pharmacist is always a good idea.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Furosemide
Insignificant DepletionBrand names include Lasix
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your body uses to support your immune system, heal tissue, and protect cells from damage. Furosemide is a strong water pill, and when it pulls extra fluid out through your kidneys, it can carry a little vitamin C along with it in the urine. That said, this has mainly been seen with IV doses given in a clinical setting, and significant depletion has not been reported with everyday oral furosemide use. For most people taking this medication, this is not something to worry about, though your pharmacist or doctor can always weigh in if you have specific concerns.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Furosemide, Potassium
Insignificant DepletionBrand names include Diumide-K Continus, Lasikal
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and wound healing all depend on, so it is worth knowing that furosemide may nudge levels slightly lower. When furosemide pulls extra water out through the kidneys, a small amount of vitamin C can leave the body with it in the urine. That said, this has only been seen with intravenous doses in a clinical setting, and significant depletion has not been reported in people taking furosemide by mouth over the long term. For most patients, no supplement is needed, but if you have questions about your diet or vitamin levels, your pharmacist or doctor is a good person to ask.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Guanethidine, Hydrochlorothiazide
Insignificant DepletionBrand names include Esimil
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and blood vessels depend on to stay healthy. Hydrochlorothiazide is a diuretic, meaning it makes your kidneys remove extra fluid, and that extra urination can carry small amounts of vitamin C out with it. That said, real vitamin C depletion from oral diuretics like this one has not been reported in practice, so most people taking this combination do not need to worry or add a supplement. If you have any concerns, your pharmacist or doctor can help you sort out whether anything extra makes sense for you.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Full nutrient report for Guanethidine, Hydrochlorothiazide →
Hydralazine, Hydrochlorothiazide
Insignificant DepletionBrand names include Apresoline-Esidrix, Apresazide
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it is worth understanding when a medication might affect it. Hydrochlorothiazide is a diuretic, meaning it helps your body shed extra fluid through urine, and that increased urine output could, in theory, carry a little extra vitamin C out with it. That said, this effect is rated insignificant, and real-world deficiency from oral diuretics like this has not been documented in studies. For most people taking this combination, no special action is needed, but if you have questions about your diet or whether a supplement makes sense for you personally, your pharmacist or doctor is a great resource.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Hydralazine, Hydrochlorothiazide, Reserpine
Insignificant DepletionBrand names include Ser-Ap-Es, Unipres, Uniserp
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and blood vessels all depend on, so it is worth knowing that diuretics like hydrochlorothiazide may carry a small amount of it out of the body through urine, simply because they increase how much water the kidneys flush away. That said, this is rated as insignificant, and real vitamin C shortfalls from long-term use of these medicines have not been reported in practice. For most people taking this combination, no extra vitamin C supplement is needed, but if you have questions or eat a limited diet, it is always fine to mention it to your pharmacist or doctor.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Full nutrient report for Hydralazine, Hydrochlorothiazide, Reserpine →
Hydrochlorothiazide
Insignificant DepletionBrand names include Esidrix, Hydro, Microzide
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system and skin tissue depend on, and there is some thinking that diuretics like hydrochlorothiazide could nudge levels down slightly by pulling more water through the kidneys, which may carry a little extra vitamin C out with it. That said, meaningful vitamin C depletion has not been reported with routine, long-term use of oral diuretics, and the evidence here is rated insignificant. For most people taking hydrochlorothiazide, this is not something to worry about, though a balanced diet with fruits and vegetables covers your bases nicely.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Hydrochlorothiazide, Irbesartan
Insignificant DepletionBrand names include Avalide
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and blood vessels depend on daily, and there is some thought that diuretics like hydrochlorothiazide could nudge levels down slightly by pulling more water through the kidneys, which may carry a little extra vitamin C out with it. That said, this has been rated as insignificant depletion, meaning real-world shortfalls from oral use have not been documented in the research. For most people taking this combination, no extra vitamin C is needed, but if you have questions about your diet or whether a supplement makes sense for you personally, your pharmacist or doctor is a great place to start.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Hydrochlorothiazide, Labetalol
Insignificant DepletionBrand names include Trandate HCT
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and blood vessels depend on to stay healthy. Because hydrochlorothiazide is a diuretic, it pulls extra water out through the kidneys, and there is some thought that vitamin C can get carried out with that extra urine flow. That said, this interaction is rated insignificant, meaning real deficiency from oral diuretics like this has not been reported in practice. No action is needed for most people, but if you ever have questions about your nutrient levels, a quick chat with your pharmacist or doctor can put your mind at ease.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Hydrochlorothiazide, Lisinopril
Insignificant DepletionBrand names include Zestoretic, Prinzide
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and blood vessels all depend on, so it's worth knowing that diuretics like hydrochlorothiazide can cause the kidneys to flush out more water than usual, and some water-soluble nutrients like vitamin C may leave the body along with it. That said, meaningful vitamin C depletion hasn't actually been reported with regular oral use of this type of diuretic, which is why this is rated as insignificant. For most people on hydrochlorothiazide, eating a diet with fruits and vegetables is plenty, and no supplement is typically needed. If you have any concerns, your pharmacist or doctor can take a look at the full picture.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Hydrochlorothiazide, Losartan Potassium
Insignificant DepletionBrand names include Hyzaar
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your body needs to support healthy skin, immune function, and tissue repair. Because hydrochlorothiazide is a diuretic, it makes you urinate more, and there is a theoretical concern that extra fluid loss could carry some vitamin C out with it. That said, this effect has not been shown to cause meaningful depletion with regular oral use of diuretics like this one, so most people taking this combination do not need to worry or take a supplement. If you eat a reasonably varied diet, you are likely fine, but feel free to mention it to your pharmacist or doctor at your next visit.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Full nutrient report for Hydrochlorothiazide, Losartan Potassium →
Hydrochlorothiazide, Methyldopa
Insignificant DepletionBrand names include Aldoril 15, Methazide, Aldoril 25
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and blood vessels count on every day. Because hydrochlorothiazide is a diuretic, it increases how much urine your body makes, and there is some thought that extra fluid leaving the body could carry a little vitamin C along with it. That said, this connection has only been observed with intravenous diuretics in people with kidney disease, and meaningful depletion has not been reported with regular oral use. For most people taking this medication combination, no extra vitamin C is needed, but mention it to your pharmacist if you have any concerns.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Hydrochlorothiazide, Metoprolol
Insignificant DepletionBrand names include Lopressor HCT
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and blood vessels all depend on, so it is worth knowing that diuretics like hydrochlorothiazide can, in theory, wash a little extra of it out through the urine simply by increasing how much water your kidneys clear. That said, this has only been shown in intravenous studies with other diuretics, and real-world depletion with oral medications like hydrochlorothiazide has not been documented. For most people on this combination, there is no reason to worry or to add a supplement. If you eat a reasonable amount of fruits and vegetables, you are almost certainly fine, but your pharmacist or doctor can weigh in if you have concerns.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Hydrochlorothiazide, Moexipril
Insignificant DepletionBrand names include Uniretic
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it is worth knowing that diuretics like hydrochlorothiazide can nudge the kidneys to flush out a little more of it along with extra water. That said, real vitamin C deficiency from oral diuretic use has not been reported in the research, and the evidence here is rated insignificant. Most people on this combination do not need to take any action, but if you have questions about your diet or whether a supplement makes sense for you, your pharmacist or doctor is a good person to ask.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Hydrochlorothiazide, Pindolol
Insignificant DepletionBrand names include Viskazide
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system and tissues depend on to stay healthy and repair themselves. Because hydrochlorothiazide is a diuretic, it makes your kidneys pass more water, and a small amount of vitamin C can leave the body along with that extra fluid. That said, this effect is rated insignificant, meaning real deficiencies have not been reported with everyday oral use of diuretics like this one. Most people taking this medication do not need a supplement for this reason, though if you have any concerns your pharmacist or doctor is the right person to ask.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Hydrochlorothiazide, Propranolol
Insignificant DepletionBrand names include Inderide
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and blood vessels all depend on, so it is worth knowing that diuretics like hydrochlorothiazide may nudge levels down slightly by causing the kidneys to flush out more water, and a small amount of vitamin C can leave the body along with it. That said, this interaction is rated insignificant, meaning meaningful depletion has not been shown with regular oral use of these medications. For most people taking this combination, no special action is needed, but if you have any concerns about your diet or nutrient levels, a quick conversation with your pharmacist or doctor can put your mind at ease.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Hydrochlorothiazide, Quinapril
Insignificant DepletionBrand names include Accuretic
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and wound healing all depend on, so it is worth understanding this note. Because hydrochlorothiazide is a diuretic, it makes your kidneys produce more urine, and there is some evidence that increased urine output can carry a little extra vitamin C out with it. That said, this has only been seen with high intravenous doses in research settings, and meaningful vitamin C depletion has not been reported with everyday oral use of diuretics like hydrochlorothiazide. For most people on this combination, no special action is needed, but your pharmacist or doctor can answer any questions you have.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Hydrochlorothiazide, Reserpine
Insignificant DepletionBrand names include Hydropres, Serpasil-Esidrix, Serpasil-Esidrix #1
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it is worth knowing that diuretics like hydrochlorothiazide can, in theory, carry a little extra vitamin C out through the urine simply by increasing how much fluid your kidneys flush out. That said, this has been rated as insignificant, and real deficiency from long-term use of diuretics taken by mouth has not been reported. For most people on this medication, no special supplement is needed, but if you have any concerns about your diet or vitamin levels, your pharmacist or doctor is a great first stop.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Hydrochlorothiazide, Spironolactone
Insignificant DepletionBrand names include Spirozine, Aldactazide, Aldactide 25
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and wound healing all depend on, so it is worth knowing that diuretics like hydrochlorothiazide and spironolactone may nudge your body to excrete a bit more of it through the urine simply because these medications increase how much water your kidneys flush out. That said, meaningful vitamin C depletion from long-term oral diuretic use has not been reported in practice, and this interaction is rated as insignificant for most people. No supplement is needed for the majority of patients taking these medications, but if you have questions or eat a limited diet, a quick conversation with your pharmacist is always a reasonable step.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Full nutrient report for Hydrochlorothiazide, Spironolactone →
Hydrochlorothiazide, Timolol
Insignificant DepletionBrand names include Timolide
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and blood vessels all depend on, so it is worth knowing that diuretics like hydrochlorothiazide may carry a small theoretical risk of nudging levels a bit lower, possibly because increased urination can wash out some water-soluble vitamins along the way. That said, significant vitamin C depletion has not been reported with regular oral use of these medications, and this interaction is rated insignificant for most people. No action is needed for the majority of patients, but if you have any concerns, a quick conversation with your pharmacist is always a good idea.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Hydrochlorothiazide, Triamterene
Insignificant DepletionBrand names include Maxzide, Dyazide, Maxzide-25
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it is worth knowing where it fits with your water pill. Hydrochlorothiazide and triamterene work by making the kidneys excrete more water and salt, and that extra fluid leaving the body can carry small amounts of vitamin C along with it. That said, this is rated as an insignificant depletion, meaning meaningful losses have not been reported with regular oral use of diuretics like these. Most people taking this combination do not need to do anything extra, though if you have questions about your diet or vitamin levels your pharmacist or doctor is a great place to start.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Hydrochlorothiazide, Valsartan
Insignificant DepletionBrand names include Diovan HCT
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and blood vessels count on every day. Because hydrochlorothiazide is a diuretic, it makes your kidneys pass more water, and a small amount of vitamin C can leave the body along with that extra fluid. In practice, though, this effect appears too minor to cause a real problem for most people taking this combination, and a supplement is not considered necessary for the average patient. If you are curious about your levels, a quick conversation with your pharmacist or doctor can put your mind at ease.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Hydroflumethiazide
Insignificant DepletionBrand names include Saluron
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it makes sense to keep an eye on it. Hydroflumethiazide is a thiazide diuretic, meaning it nudges your kidneys to pass more water and some dissolved nutrients out through the urine, and vitamin C can tag along for the ride. That said, real-world evidence of meaningful vitamin C loss with oral diuretics like this one is lacking, so most people taking hydroflumethiazide simply do not need to worry about this or add a supplement. If you have any concerns, a quick chat with your pharmacist or doctor can put your mind at ease.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Hydroflumethiazide, Reserpine
Insignificant DepletionBrand names include Salutensin-Demi, Salutensin
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it is worth knowing that diuretics like hydroflumethiazide can theoretically nudge your body to excrete a little more of it through the urine simply because they increase how much water you flush out. That said, real-world evidence has not shown meaningful vitamin C shortfalls with long-term use of oral diuretics, and this combination is rated as an insignificant depletion. For most people taking this medication, no special action is needed, but if you have any concerns about your diet or nutrition, a quick chat with your pharmacist or doctor can put your mind at ease.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Indapamide
Insignificant DepletionBrand names include Lozol, Lozide
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and wound healing all depend on, so it is worth knowing that diuretics like indapamide can, in theory, cause a little more of it to leave the body through urine simply because these medications increase how much water the kidneys flush out. That said, real vitamin C depletion from oral diuretics has not been reported in practice, and this interaction is rated as insignificant for most people. No extra supplement is needed for the typical indapamide user, but if you have concerns or eat a diet low in fruits and vegetables, a quick chat with your pharmacist is always a reasonable step.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Irbesartan, Hydrochlorothiazide
Insignificant DepletionBrand names include CoAprovel
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it is worth knowing that the hydrochlorothiazide in this combination pill is a diuretic, meaning it makes your kidneys remove extra fluid. That flushing action can carry a small amount of vitamin C out in the urine along with the water. In practice, though, meaningful vitamin C loss has not been reported with regular oral use of diuretics like this one, so for most people taking this medication no extra supplementation is needed. If you ever have concerns, a quick conversation with your pharmacist or doctor can put your mind at ease.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Levonorgestrel, Ethinyl Estradiol
Insignificant DepletionBrand names include Nordette, Logynon ED, Microgynon 30
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your body uses to support immune health, skin, and tissue repair, and there is some research suggesting that the estrogen component in birth control pills like this one may interfere with how well your gut absorbs it or how quickly your body breaks it down. That said, the evidence here is genuinely mixed and the overall rating is insignificant, meaning for most people eating a reasonably balanced diet, this is not a practical concern. If your vitamin C intake is already very low, it may be worth a quick conversation with your pharmacist or doctor, but a supplement is not something most people in this situation need.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Full nutrient report for Levonorgestrel, Ethinyl Estradiol →
Mannitol
Insignificant DepletionBrand names include Osmitrol, Bronchitol
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and wound healing all depend on, so it is worth knowing that mannitol, a diuretic given intravenously in hospital settings, could theoretically carry a little extra vitamin C out through the urine simply because it pulls so much water through the kidneys. That said, any such loss is considered insignificant, and meaningful vitamin C depletion has not been reported with diuretics like this. For most patients receiving mannitol, no special supplementation is needed, though if you have questions about your own situation, a quick word with your pharmacist or doctor is always a reasonable step.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Medroxyprogesterone Acetate, Oestrogens, Conjugated
Insignificant DepletionBrand names include Premique
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C helps your body fight oxidative stress and keeps tissues healthy, so it's a nutrient worth knowing about. Some research suggests estrogen-based hormones like these may slightly reduce vitamin C levels, possibly because the body uses vitamin C to help process estrogens in tissue, or because absorption in the gut is mildly affected. That said, the evidence is mixed, and for anyone eating a reasonably balanced diet, this is considered insignificant. No supplement is needed for most people, but if you have questions about your diet or vitamin C intake, your pharmacist or doctor is a good person to ask.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Full nutrient report for Medroxyprogesterone Acetate, Oestrogens, Conjugated →
Methazolamide
Insignificant DepletionBrand names include Neptazane
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and wound healing all depend on, so it is worth knowing that diuretics like methazolamide can occasionally nudge levels a little lower, likely because increased urine output carries a small amount of it out of the body. That said, this is rated as an insignificant depletion, meaning real-world deficiency from methazolamide has not been meaningfully documented. For most people taking this medication, no special action is needed, though it never hurts to mention it to your pharmacist if you have concerns.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Methyclothiazide
Insignificant DepletionBrand names include Enduron, Aquatensen
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it is worth knowing that diuretics like methyclothiazide can, in theory, cause a little more of it to leave the body through the urine simply because these medications increase how much water the kidneys flush out. That said, a real vitamin C shortage from long-term use of oral diuretics has not been reported, and this interaction is rated insignificant, meaning most people taking methyclothiazide do not need to take any action. If you want peace of mind, eating plenty of fruits and vegetables covers your bases, and your pharmacist or doctor can help you decide if anything more is needed.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Methyclothiazide, Pargyline
Insignificant DepletionBrand names include Eutron
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and wound healing all depend on, so it is worth knowing that diuretics like methyclothiazide may slightly increase how much your body loses through urine, simply because these medications make you excrete more water overall. That said, this connection is rated as insignificant, meaning real vitamin C deficiency from long-term diuretic use has not been well documented in practice. For most people taking this medication, there is no particular reason to worry or to start a supplement. If you have any concerns, a quick conversation with your pharmacist or doctor can put your mind at ease.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Methyclothiazide, Reserpine
Insignificant DepletionBrand names include Diutensen-R
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it is worth knowing that diuretics like methyclothiazide can, in theory, nudge your body to excrete a little more of it in the urine along with extra water. That said, this concern is rated insignificant, meaning real-world deficiency from long-term use of oral diuretics like this one has not been shown to be a meaningful problem. For most people taking this combination, no extra vitamin C is needed, but if you have questions or eat a limited diet, a quick chat with your pharmacist is always a good idea.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Metolazone
Insignificant DepletionBrand names include Diulo, Zaroxolyn, Mykrox
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and tissue repair all depend on. Because metolazone is a diuretic that pulls extra water out through your kidneys, there is some thought that vitamin C could ride along and be lost in the urine as well. That said, meaningful vitamin C depletion has not actually been reported with long-term use of oral diuretics like metolazone, so most people taking it do not need to worry about this. If you have any concerns, your pharmacist or doctor can help you decide whether anything extra is worth doing.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Norelgestromin, Ethinyl Estradiol
Insignificant DepletionBrand names include Ortho Evra, Evra
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your body uses to support immune function, skin health, and tissue repair, so keeping steady levels matters. The estrogen component of this patch has been linked to slightly lower vitamin C in some studies, possibly because estrogen speeds up how the body breaks vitamin C down or uses it up as an antioxidant. The research here is genuinely mixed, though, and the overall rating is insignificant, meaning that for most people eating a reasonable diet, this is not something to worry about. If your diet is already light on fruits and vegetables, it is worth a quick conversation with your pharmacist or doctor.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Full nutrient report for Norelgestromin, Ethinyl Estradiol →
Norethindrone Acetate, Ethinyl Estradiol, Ferrous Fumarate
Insignificant DepletionBrand names include Minastrin 24 FE, LoMinastrin FE
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it is worth understanding this one. The estrogen component in this pill may modestly reduce vitamin C levels, possibly because the body uses vitamin C to help process estrogen in tissues, or because estrogen slightly affects how much vitamin C the gut absorbs. That said, the evidence here is genuinely mixed and the overall rating is insignificant, meaning most people taking this pill who eat a reasonable amount of fruits and vegetables are unlikely to have any real issue. If your diet is low in vitamin C, it is worth mentioning to your pharmacist or doctor at your next visit.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Full nutrient report for Norethindrone Acetate, Ethinyl Estradiol, Ferrous Fumarate →
Oestrogen
Insignificant DepletionEvidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your body uses to support immune function, skin, and tissue repair, and there is some research suggesting oestrogen may slightly reduce how well it is absorbed or cause the body to use it up a bit faster. That said, the evidence here is genuinely mixed, and this is rated as an insignificant depletion, meaning it is not considered a real concern for most people taking oestrogen who eat a reasonably varied diet. If your vitamin C intake is already quite low, it might be worth a quick chat with your pharmacist, but for the majority of people, no supplement is needed.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Polythiazide
Insignificant DepletionBrand names include Renese
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it is worth knowing that thiazide diuretics like polythiazide may nudge levels slightly lower, likely because they increase how much water your kidneys flush out, and vitamin C can leave the body along with that extra fluid. That said, the evidence here is rated insignificant, meaning real deficiency from long-term use of this type of diuretic has not been documented in practice. Most people taking polythiazide do not need to worry about this or add a supplement, but if you have any concerns, a quick conversation with your pharmacist or doctor can put your mind at ease.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Polythiazide, Prazosin
Insignificant DepletionBrand names include Minizide
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and blood vessels all depend on, so it is worth understanding where it fits here. Because polythiazide is a diuretic, it makes the kidneys produce more urine, and that extra fluid leaving the body can carry a small amount of vitamin C along with it. That said, this interaction is rated as insignificant, meaning meaningful depletion has not been documented with regular oral use of diuretics like this one. For most people taking this combination, no special action is needed, but if you have any concerns, a quick conversation with your pharmacist is always a reasonable step.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Polythiazide, Reserpine
Insignificant DepletionBrand names include Renese R
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and healing processes all depend on. Because polythiazide is a diuretic, it makes your kidneys produce more urine, and there is some thought that extra water loss could carry a small amount of vitamin C along with it. That said, meaningful vitamin C depletion has not been reported with long-term use of oral diuretics like this one, and the evidence here is rated insignificant. Most people on this combination do not need to worry, but if you have questions about your diet or a supplement, your pharmacist or doctor is a good place to start.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Prasterone (prescription drug)
Insignificant DepletionBrand names include Intrarosa
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Prasterone is a prescription form of DHEA that the body converts into estrogens, and those estrogens may have a mild effect on vitamin C, which your immune system and skin rely on for tissue repair and protection against cell damage. The thinking is that estrogens might slightly reduce how well vitamin C is absorbed in the gut, or that the body uses a bit more of it to keep estrogens from oxidizing in tissue. That said, the evidence here is genuinely mixed and the overall rating is insignificant, meaning this is not a concern for most people who eat a reasonably varied diet. If you are ever worried about your vitamin C intake, a quick chat with your pharmacist is all it takes.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Quinethazone
Insignificant DepletionBrand names include Hydromox
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and wound healing all depend on, so it is worth understanding how quinethazone might relate to your levels. Quinethazone is a diuretic, meaning it helps your kidneys pass more water and salt out through urine, and that extra urine flow can carry some vitamin C along with it. That said, this interaction is rated insignificant, and meaningful vitamin C depletion has not been reported with long-term use of diuretics like this one taken by mouth. Most people on quinethazone do not need to do anything about this, but if you have any concerns, a quick chat with your pharmacist is always a good idea.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Quinethazone, Reserpine
Insignificant DepletionBrand names include Hydromox R
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it is worth knowing that diuretics like quinethazone may nudge levels down slightly by increasing how much water your kidneys flush out, which can carry a little extra vitamin C along with it. That said, meaningful depletion simply has not been reported with regular oral use of this type of diuretic, and the evidence rating here is insignificant. For most people taking this combination, no special action is needed, but if you have any concerns about your diet or vitamin levels, your pharmacist or doctor is a good person to ask.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Relugolix, Estradiol, Norethindrone Acetate
Insignificant DepletionBrand names include Myfembree
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
The estradiol component of this combination medication is the part that may nudge vitamin C levels slightly lower, since estrogen appears to compete with vitamin C absorption in the gut and may also cause the body to use vitamin C more quickly as it works to neutralize estrogen in tissues. That said, the evidence here is mixed and the rating is insignificant, meaning this is not something most people need to worry about. As long as you are eating a reasonable variety of fruits and vegetables, your intake is likely plenty sufficient. If you have concerns about your diet, a quick conversation with your pharmacist or doctor can help you sort out whether anything extra makes sense for you.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Full nutrient report for Relugolix, Estradiol, Norethindrone Acetate →
Reserpine, Trichlormethiazide
Insignificant DepletionBrand names include Naquival, Metatensin #2, Metatensin #4
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Trichlormethiazide is a diuretic, meaning it helps your kidneys remove extra fluid, and there is some thought that flushing out more water could carry a bit of vitamin C out with it. Vitamin C is something your body uses for immune defense, wound healing, and keeping tissues healthy. That said, real-world evidence has not shown meaningful vitamin C loss with oral diuretics like this one, so the rating here is insignificant. Most people taking this combination do not need to worry about it, but if you have any concerns, a quick conversation with your pharmacist or doctor can put your mind at ease.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Sacubitril, Valsartan
Insignificant DepletionBrand names include Entresto
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and blood vessels depend on every day. Sacubitril/valsartan contains a component that works partly like a diuretic, meaning it can nudge the kidneys to pass more fluid, and some research suggests that extra fluid loss may carry a small amount of vitamin C out in the urine along with it. That said, real vitamin C depletion from oral heart medications like this one has not been reported in practice, so this is rated insignificant. No action is needed for most people, but if you have questions about your diet or any supplements, your pharmacist or doctor is a great place to start.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Segesterone Acetate, Ethinyl Estradiol
Insignificant DepletionBrand names include Annovera
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Vitamin C is something your immune system, skin, and tissues depend on every day, so it is worth knowing that the estrogen component in this contraceptive ring has been loosely linked to lower vitamin C levels in some studies. Researchers think estrogen may slow how well the gut absorbs vitamin C or speed up how quickly the body breaks it down, though the evidence is genuinely mixed. For most people using this ring who eat a reasonable diet with fruits and vegetables, this is considered an insignificant concern and no supplement is needed. If you eat very little vitamin C regularly, it is worth a quick conversation with your pharmacist or doctor.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Full nutrient report for Segesterone Acetate, Ethinyl Estradiol →
Spironolactone
Insignificant DepletionBrand names include Aldactone, Spiroton, Carospir
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and wound healing all depend on, so it is worth knowing that diuretics like spironolactone may, in theory, nudge urinary losses slightly higher simply by increasing how much water your kidneys flush out. That said, meaningful vitamin C depletion has not been reported with regular oral use of diuretics, and the evidence here is rated insignificant. Most people taking spironolactone do not need to do anything extra about this, but if you have questions about your diet or whether a supplement makes sense for you, your pharmacist or doctor is the right person to ask.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Theobromine
Insignificant DepletionIn people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Theobromine is a mild diuretic, meaning it nudges your kidneys to pass more water, and there is some thought that extra water loss could carry a little vitamin C out with it. Vitamin C is something your body depends on for healthy skin, immune function, and wound healing. That said, any effect here is considered insignificant, and real deficiency from this kind of drug has not been reported with regular use. Most people taking theobromine have no reason to worry about this, but if you have questions, a quick chat with your pharmacist is always a good idea.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Tibolone
Insignificant DepletionBrand names include Livial
Evidence on the effects of oral contraceptives and hormone replacement therapy on vitamin C levels is conflicting. It's suggested that estrogens can reduce vitamin C absorption or increase its breakdown, and that vitamin C stores are used to prevent oxidation of estrogens in tissue. This may only be clinically relevant in patients with very low intake of vitamin C. Supplements aren't necessary for people on estrogens who have an adequate dietary intake of vitamin C.
Tibolone has estrogenic activity in the body, and there is some research suggesting that estrogens may slightly reduce vitamin C levels, possibly by limiting how well the gut absorbs it or by using it up as the body processes estrogen in tissues. That said, the evidence here is conflicting and the effect is considered insignificant for most people. If you eat a reasonably varied diet with fruits and vegetables, you almost certainly do not need a vitamin C supplement because of tibolone, though it is always fine to mention it to your pharmacist if you have questions.
References (9)
- Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. DOI
- Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277. PubMed
- Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. PubMed
- Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. DOI
- Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64.
- McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. PubMed
- Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. PubMed
- Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9.
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
Torsemide
Insignificant DepletionBrand names include Demadex, Soaanz
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Torsemide is a loop diuretic, meaning it works by making your kidneys pull extra fluid out of your body through urine. Because more water is being flushed out, small amounts of vitamin C (which supports your immune system, skin, and wound healing) can tag along for the ride. That said, this effect looks to be pretty minor in practice, and significant vitamin C depletion has not been reported with regular oral use of drugs in this class. Most people taking torsemide do not need to do anything special about this, but if you have concerns, a quick chat with your pharmacist is always a good idea.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Trichlormethiazide
Insignificant DepletionBrand names include Metahydrin, Naqua, Marazide II
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it makes sense to keep an eye on it. Trichlormethiazide is a thiazide diuretic, meaning it makes your kidneys push out more water and salt, and that extra urine flow can carry a little vitamin C out with it. That said, meaningful vitamin C depletion has not been reported with regular oral use of diuretics like this one, and most people taking trichlormethiazide do not need to do anything special about this. If you have any concerns, a quick chat with your pharmacist or doctor can put your mind at ease.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Urea
Insignificant DepletionBrand names include Ureaphil
In people with chronic renal failure, a 20 mg intravenous dose of furosemide (Lasix) increases urinary losses of vitamin C, probably due to increased water excretion. Significant vitamin C depletion hasn't been reported with long-term oral use of furosemide or other diuretics.
Vitamin C is something your immune system, skin, and wound healing all depend on, so it is worth knowing how your medications interact with it. Urea is a diuretic, meaning it pulls extra water out through the kidneys, and that process can carry some vitamin C along with it in the urine. That said, this interaction is rated insignificant, and meaningful vitamin C loss from diuretics like this has not been shown in people taking them by mouth over the long term. Most people using urea do not need to do anything differently, but if you have any concerns, a quick conversation with your pharmacist is always a good idea.
References (1)
- Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6..
Amlodipine
Insufficient EvidenceBrand names include Norliqva
DCCBs inhibit uptake of vitamin C by intestinal cells in vitro. Whether this causes a clinically significant reduction in vitamin C absorption in humans is not known.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it is worth knowing that amlodipine belongs to a drug class that, in laboratory studies, appeared to interfere with how intestinal cells take up vitamin C. That said, whether this actually plays out in a meaningful way in real people is simply not known yet. The evidence here is early and inconclusive, so there is no reason to worry, but if you take amlodipine long-term and are curious about your vitamin C intake, it is a fine question to raise with your pharmacist or doctor.
References (1)
- Kuo SM, Lin CP, Morehouse HF Jr. Dihydropyridine calcium channel blockers inhibit ascorbic acid accumulation in human intestinal Caco-2 cells. Life Sci 2001;68:1751-60.. PubMed
Amlodipine Benzoate
Insufficient EvidenceBrand names include Katerzia
DCCBs inhibit uptake of vitamin C by intestinal cells in vitro. Whether this causes a clinically significant reduction in vitamin C absorption in humans is not known.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it is worth knowing that amlodipine belongs to a drug class that showed some interference with how intestinal cells take up vitamin C in lab studies. That said, this has only been seen in test-tube research, and nobody has shown it actually leads to lower vitamin C levels in people taking amlodipine. The evidence here is truly preliminary, so most people on this medication do not need to do anything differently, but if you have questions or eat a diet low in fruits and vegetables, a quick conversation with your pharmacist or doctor is always a reasonable step.
References (1)
- Kuo SM, Lin CP, Morehouse HF Jr. Dihydropyridine calcium channel blockers inhibit ascorbic acid accumulation in human intestinal Caco-2 cells. Life Sci 2001;68:1751-60.. PubMed
Amlodipine Besilate
Insufficient EvidenceBrand names include Istin
DCCBs inhibit uptake of vitamin C by intestinal cells in vitro. Whether this causes a clinically significant reduction in vitamin C absorption in humans is not known.
Amlodipine belongs to a drug class that, in laboratory studies, appears to interfere with how intestinal cells take up vitamin C, the nutrient your immune system, skin, and wound healing depend on. That said, those findings come from cell-based research, not from studies in actual people, so whether this matters at real-world doses is genuinely unknown. The current evidence is simply too limited to say there is a meaningful concern, and most people on amlodipine do not need to worry about this. If you have questions about your vitamin C intake, it is worth a quick conversation with your pharmacist or doctor.
References (1)
- Kuo SM, Lin CP, Morehouse HF Jr. Dihydropyridine calcium channel blockers inhibit ascorbic acid accumulation in human intestinal Caco-2 cells. Life Sci 2001;68:1751-60.. PubMed
Amlodipine Besylate
Insufficient EvidenceBrand names include Norvasc
DCCBs inhibit uptake of vitamin C by intestinal cells in vitro. Whether this causes a clinically significant reduction in vitamin C absorption in humans is not known.
Vitamin C is something your immune system, skin, and wound healing all depend on, so it is worth understanding this one. Amlodipine belongs to a class of blood pressure medicines that, in lab studies, appears to interfere with how intestinal cells take up vitamin C from food. That said, those were test-tube findings, and whether the same thing happens in a meaningful way in real people simply is not known yet. The evidence here is genuinely too limited to draw conclusions, so most people on amlodipine do not need to act on this, though it is always fine to mention it to your pharmacist if you are curious.
References (1)
- Kuo SM, Lin CP, Morehouse HF Jr. Dihydropyridine calcium channel blockers inhibit ascorbic acid accumulation in human intestinal Caco-2 cells. Life Sci 2001;68:1751-60.. PubMed
Amlodipine Besylate, Benazepril
Insufficient EvidenceBrand names include Lotrel
DCCBs inhibit uptake of vitamin C by intestinal cells in vitro. Whether this causes a clinically significant reduction in vitamin C absorption in humans is not known.
Amlodipine, the calcium channel blocker in this combination, belongs to a drug class that laboratory studies suggest might interfere with how intestinal cells take up vitamin C, a nutrient your immune system and tissues depend on for repair. That said, those findings come from lab experiments, not human studies, so nobody yet knows whether this actually lowers vitamin C levels in real patients. With the evidence rated insufficient, there is no reason to worry right now, but if you are a long-term user, it is a reasonable thing to mention to your pharmacist.
References (1)
- Kuo SM, Lin CP, Morehouse HF Jr. Dihydropyridine calcium channel blockers inhibit ascorbic acid accumulation in human intestinal Caco-2 cells. Life Sci 2001;68:1751-60.. PubMed
Amlodipine, Celecoxib
Insufficient EvidenceBrand names include Consensi
DCCBs inhibit uptake of vitamin C by intestinal cells in vitro. Whether this causes a clinically significant reduction in vitamin C absorption in humans is not known.
Vitamin C is something your immune system, skin, and wound healing all depend on, so it is worth knowing that amlodipine, a type of calcium channel blocker, has shown in lab studies that it may interfere with how intestinal cells take up vitamin C. That said, this has only been seen in lab settings, not confirmed in real patients, which is why the evidence is currently rated as insufficient. Most people taking amlodipine do not need to worry about this, but if you have questions or want to discuss your diet or vitamin intake, your pharmacist or doctor is a great place to start.
References (1)
- Kuo SM, Lin CP, Morehouse HF Jr. Dihydropyridine calcium channel blockers inhibit ascorbic acid accumulation in human intestinal Caco-2 cells. Life Sci 2001;68:1751-60.. PubMed
Amoxicillin, Omeprazole Magnesium, Rifabutin
Insufficient EvidenceBrand names include Talicia
Preliminary research suggests omeprazole reduces vitamin C levels, possibly due to increased destruction of vitamin C at higher gastric pH levels. It is not known if this interaction results in clinically significant reductions in vitamin C levels.
Omeprazole is the drug in this combination most likely connected to vitamin C, which your immune system, skin, and wound healing all depend on. Here is the thinking: omeprazole reduces stomach acid, and some early research suggests that a less acidic stomach environment may actually break down vitamin C before the body can absorb it properly. That said, the evidence is still quite preliminary, and researchers are not yet sure whether this leads to any real-world shortfall in most people. If you are on long-term omeprazole and have questions about your vitamin C intake, it is worth bringing up with your pharmacist or doctor.
References (1)
- Mowat C, Carswell A, Wirz A, McColl KE. Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice. Gastroenterology 1999;116:813-22. PubMed
Full nutrient report for Amoxicillin, Omeprazole Magnesium, Rifabutin →
Bepridil
Insufficient EvidenceBrand names include Vascor
DCCBs inhibit uptake of vitamin C by intestinal cells in vitro. Whether this causes a clinically significant reduction in vitamin C absorption in humans is not known.
Bepridil belongs to a class of calcium channel blockers, and there is some early lab research suggesting these drugs might interfere with how intestinal cells take up vitamin C, the nutrient your immune system and skin tissues depend on. That said, this has only been seen in test-tube studies so far, and nobody knows yet whether it actually affects vitamin C levels in real patients. Given the 'insufficient evidence' rating, there is no reason to be alarmed right now. If you are a long-term bepridil user and are curious, it is worth a quick conversation with your pharmacist or doctor.
References (1)
- Kuo SM, Lin CP, Morehouse HF Jr. Dihydropyridine calcium channel blockers inhibit ascorbic acid accumulation in human intestinal Caco-2 cells. Life Sci 2001;68:1751-60.. PubMed
Dexlansoprazole
Insufficient EvidenceBrand names include Dexilant Solutab
Preliminary research suggests omeprazole reduces vitamin C levels, possibly due to increased destruction of vitamin C at higher gastric pH levels. It is not known if this interaction results in clinically significant reductions in vitamin C levels.
Vitamin C is something your immune system, skin, and wound healing all depend on, so it is worth knowing that dexlansoprazole, like other proton pump inhibitors, may have some effect on it. The thinking is that when stomach acid is reduced, the environment in the stomach changes, and vitamin C may break down more easily there before your body can absorb it. That said, the research here is very early and limited, and right now there simply is not enough evidence to know whether this matters in a real, practical way for most people. If you take dexlansoprazole long-term and are curious, it is a reasonable thing to bring up with your pharmacist or doctor.
References (1)
- Mowat C, Carswell A, Wirz A, McColl KE. Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice. Gastroenterology 1999;116:813-22. PubMed
Diltiazem
Insufficient EvidenceBrand names include Cardizem, Cardizem SR, Diltiaz SR
DCCBs inhibit uptake of vitamin C by intestinal cells in vitro. Whether this causes a clinically significant reduction in vitamin C absorption in humans is not known.
Vitamin C is something your body depends on for healthy skin, wound healing, and a strong immune system. There is some early lab research suggesting that calcium channel blockers like diltiazem might interfere with how intestinal cells take up vitamin C, but this has only been seen in lab studies, not confirmed in people. The evidence here is really too thin to know whether it matters in real life. If you take diltiazem long term and have questions about your vitamin C intake, it is worth a quick conversation with your pharmacist or doctor.
References (1)
- Kuo SM, Lin CP, Morehouse HF Jr. Dihydropyridine calcium channel blockers inhibit ascorbic acid accumulation in human intestinal Caco-2 cells. Life Sci 2001;68:1751-60.. PubMed
Diltiazem, Enalapril
Insufficient EvidenceBrand names include Teczem
DCCBs inhibit uptake of vitamin C by intestinal cells in vitro. Whether this causes a clinically significant reduction in vitamin C absorption in humans is not known.
Vitamin C is something your body relies on for healthy skin, immune function, and tissue repair. There is some lab-based research suggesting that calcium channel blockers like diltiazem might interfere with how intestinal cells take up vitamin C, but this has only been seen in laboratory studies, not confirmed in people. The evidence here is truly preliminary, so most patients taking diltiazem or enalapril do not need to worry about this right now. That said, if you have concerns or eat a diet low in fruits and vegetables, it is always worth a quick conversation with your pharmacist or doctor.
References (1)
- Kuo SM, Lin CP, Morehouse HF Jr. Dihydropyridine calcium channel blockers inhibit ascorbic acid accumulation in human intestinal Caco-2 cells. Life Sci 2001;68:1751-60.. PubMed
Enalapril Maleate, Felodipine
Insufficient EvidenceBrand names include Lexxel
DCCBs inhibit uptake of vitamin C by intestinal cells in vitro. Whether this causes a clinically significant reduction in vitamin C absorption in humans is not known.
Felodipine belongs to a drug class that, in lab studies, appears to interfere with how intestinal cells take up vitamin C, the nutrient your immune system and skin tissue depend on. That said, these were test-tube findings, and nobody has confirmed this actually lowers vitamin C levels in people taking the medication. The evidence is too thin right now to know whether it matters clinically, so most patients don't need to worry. If you have concerns or eat a diet low in fruits and vegetables, it's worth a quick conversation with your pharmacist or doctor.
References (1)
- Kuo SM, Lin CP, Morehouse HF Jr. Dihydropyridine calcium channel blockers inhibit ascorbic acid accumulation in human intestinal Caco-2 cells. Life Sci 2001;68:1751-60.. PubMed
Esomeprazole
Insufficient EvidenceBrand names include Nexium
Preliminary research suggests omeprazole reduces vitamin C levels, possibly due to increased destruction of vitamin C at higher gastric pH levels. It is not known if this interaction results in clinically significant reductions in vitamin C levels.
Here is something interesting that researchers have noticed: esomeprazole, like other acid-reducing drugs in its class, raises the pH inside your stomach, and early evidence suggests that a higher, less acidic stomach environment may actually break down vitamin C before your body can absorb it. Vitamin C is the nutrient your immune system and skin-repair processes depend on heavily. That said, the evidence here is still very preliminary, and nobody knows yet whether this translates into a real, meaningful drop for people taking the medication. Most patients do not need to act on this, but if you have been on esomeprazole long-term and are curious, it is worth a quick conversation with your pharmacist.
References (1)
- Mowat C, Carswell A, Wirz A, McColl KE. Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice. Gastroenterology 1999;116:813-22. PubMed
Esomeprazole Magnesium
Insufficient EvidenceBrand names include Nexium 24hr
Preliminary research suggests omeprazole reduces vitamin C levels, possibly due to increased destruction of vitamin C at higher gastric pH levels. It is not known if this interaction results in clinically significant reductions in vitamin C levels.
Vitamin C is something your immune system, skin, and wound healing all depend on, so it is worth understanding this one. Esomeprazole works by raising the acid level in your stomach, and there is early research suggesting that a less acidic stomach environment may actually break down vitamin C before your body can absorb it. That said, the evidence here is still very preliminary, and whether this causes any real-world problem for most people is simply not known yet. If you have been on this medication long-term and are curious, it is a reasonable thing to bring up with your pharmacist or doctor.
References (1)
- Mowat C, Carswell A, Wirz A, McColl KE. Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice. Gastroenterology 1999;116:813-22. PubMed
Esomeprazole Strontium
Insufficient EvidencePreliminary research suggests omeprazole reduces vitamin C levels, possibly due to increased destruction of vitamin C at higher gastric pH levels. It is not known if this interaction results in clinically significant reductions in vitamin C levels.
Vitamin C is something your immune system, skin, and wound healing all depend on, so it is worth knowing that proton pump inhibitors like esomeprazole strontium may have some effect on it. Because this drug reduces stomach acid, early research suggests the higher pH environment in the stomach may cause vitamin C to break down more quickly before it can be absorbed. That said, the evidence here is still very preliminary, and nobody knows yet whether this leads to any real-world shortage in the body. If you take this medication long-term and have concerns, a quick conversation with your pharmacist or doctor is the most sensible next step.
References (1)
- Mowat C, Carswell A, Wirz A, McColl KE. Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice. Gastroenterology 1999;116:813-22. PubMed
Esomeprazole, Naproxen
Insufficient EvidenceBrand names include Vimovo
Preliminary research suggests omeprazole reduces vitamin C levels, possibly due to increased destruction of vitamin C at higher gastric pH levels. It is not known if this interaction results in clinically significant reductions in vitamin C levels.
Vitamin C is something your immune system, skin, and wound healing all depend on, so it is worth knowing that proton pump inhibitors like esomeprazole might affect how much of it stays in your body. The thinking is that these medications raise the pH inside your stomach, and vitamin C may break down more quickly in a less acidic environment before it even gets absorbed. That said, the evidence here is early and limited, so nobody knows yet whether this translates into a real, meaningful drop for most people. If you have been on esomeprazole long-term and are curious, it is a reasonable thing to bring up with your pharmacist or doctor.
References (1)
- Mowat C, Carswell A, Wirz A, McColl KE. Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice. Gastroenterology 1999;116:813-22. PubMed
Felodipine
Insufficient EvidenceBrand names include Plendil, Renedil
DCCBs inhibit uptake of vitamin C by intestinal cells in vitro. Whether this causes a clinically significant reduction in vitamin C absorption in humans is not known.
Felodipine belongs to a group of blood pressure medications that, in laboratory studies, appears to interfere with how intestinal cells take up vitamin C, a nutrient your immune system and skin repair processes depend on. That said, nobody has confirmed this actually plays out in a meaningful way in real patients, so the evidence right now is simply too thin to know whether it matters. Most people taking felodipine do not need to worry about this or change anything because of it. If you are curious or take felodipine long-term, it is always fine to bring it up with your pharmacist or doctor.
References (1)
- Kuo SM, Lin CP, Morehouse HF Jr. Dihydropyridine calcium channel blockers inhibit ascorbic acid accumulation in human intestinal Caco-2 cells. Life Sci 2001;68:1751-60.. PubMed
Isradipine
Insufficient EvidenceBrand names include Dynacirc CR
DCCBs inhibit uptake of vitamin C by intestinal cells in vitro. Whether this causes a clinically significant reduction in vitamin C absorption in humans is not known.
Vitamin C is something your immune system, skin, and wound healing all depend on, so it is worth understanding this. Isradipine belongs to a drug class that, in laboratory studies, appears to interfere with how intestinal cells take up vitamin C from food. The catch is that those studies were done in a test tube, not in people, so nobody yet knows whether this translates to a real drop in vitamin C levels in actual patients. The evidence here is simply too limited to draw firm conclusions, and most people taking isradipine do not need to worry about this, though it is always fine to mention it to your pharmacist or doctor if you have concerns.
References (1)
- Kuo SM, Lin CP, Morehouse HF Jr. Dihydropyridine calcium channel blockers inhibit ascorbic acid accumulation in human intestinal Caco-2 cells. Life Sci 2001;68:1751-60.. PubMed
Lansoprazole
Insufficient EvidenceBrand names include Prevacid
Preliminary research suggests omeprazole reduces vitamin C levels, possibly due to increased destruction of vitamin C at higher gastric pH levels. It is not known if this interaction results in clinically significant reductions in vitamin C levels.
Vitamin C is something your immune system, skin, and tissue repair all depend on, so it is worth knowing that lansoprazole belongs to a class of drugs that raises the pH inside your stomach. Some early research hints that a less acidic stomach environment may actually break down vitamin C before your body can absorb it, leaving less available. That said, the evidence here is quite preliminary, and nobody knows yet whether this causes a real, meaningful drop in vitamin C for most people taking these medications. If you have been on lansoprazole long-term and are curious, it is a reasonable thing to bring up with your pharmacist or doctor.
References (1)
- Mowat C, Carswell A, Wirz A, McColl KE. Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice. Gastroenterology 1999;116:813-22. PubMed
Lansoprazole, Amoxicillin, Clarithromycin
Insufficient EvidenceBrand names include Prevpac
Preliminary research suggests omeprazole reduces vitamin C levels, possibly due to increased destruction of vitamin C at higher gastric pH levels. It is not known if this interaction results in clinically significant reductions in vitamin C levels.
Vitamin C is something your immune system, skin, and wound healing all depend on. There is early, limited research suggesting that proton pump inhibitors like lansoprazole might reduce vitamin C levels, possibly because raising the stomach's pH changes how vitamin C behaves in the gut before it can be absorbed. That said, the evidence here is genuinely preliminary, and no one knows yet whether this causes a real-world problem for most people. If you are on long-term therapy with this combination and are curious about your vitamin C status, it is worth a quick conversation with your pharmacist or doctor.
References (1)
- Mowat C, Carswell A, Wirz A, McColl KE. Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice. Gastroenterology 1999;116:813-22. PubMed
Full nutrient report for Lansoprazole, Amoxicillin, Clarithromycin →
Lercanidipine hydrochloride
Insufficient EvidenceBrand names include Zanidip
DCCBs inhibit uptake of vitamin C by intestinal cells in vitro. Whether this causes a clinically significant reduction in vitamin C absorption in humans is not known.
Vitamin C is something your immune system, skin, and tissue repair all depend on. Lercanidipine belongs to a drug class that, in lab studies, appears to interfere with how intestinal cells take up vitamin C from food. That said, whether this actually matters in a real person taking the medication is genuinely unknown, so the evidence is rated insufficient. Most people on lercanidipine do not need to worry about this, but if you take it long-term and have questions about your diet or vitamin levels, it is worth a quick chat with your pharmacist or doctor.
References (1)
- Kuo SM, Lin CP, Morehouse HF Jr. Dihydropyridine calcium channel blockers inhibit ascorbic acid accumulation in human intestinal Caco-2 cells. Life Sci 2001;68:1751-60.. PubMed
Levamlodipine
Insufficient EvidenceBrand names include Conjupri
DCCBs inhibit uptake of vitamin C by intestinal cells in vitro. Whether this causes a clinically significant reduction in vitamin C absorption in humans is not known.
Levamlodipine belongs to a drug class that, in laboratory studies, appears to interfere with how intestinal cells take up vitamin C, the nutrient your immune system and skin-healing processes depend on. That said, whether this actually matters in a living person is simply not known yet, and the evidence is too limited to draw real conclusions. Most people taking this medication do not need to worry about their vitamin C levels based on what we currently know. If you are curious or have concerns, it is worth a quick chat with your pharmacist or doctor.
References (1)
- Kuo SM, Lin CP, Morehouse HF Jr. Dihydropyridine calcium channel blockers inhibit ascorbic acid accumulation in human intestinal Caco-2 cells. Life Sci 2001;68:1751-60.. PubMed
Nicardipine
Insufficient EvidenceBrand names include Cardene, Cardene SR, Cardene IV
DCCBs inhibit uptake of vitamin C by intestinal cells in vitro. Whether this causes a clinically significant reduction in vitamin C absorption in humans is not known.
Nicardipine belongs to a class of blood pressure medications that, in laboratory studies, appears to interfere with how intestinal cells take up vitamin C, the nutrient your immune system and skin repair rely on. That said, whether this actually reduces vitamin C levels in real people is simply not known yet, so the evidence is genuinely preliminary. Most people taking nicardipine do not need to worry about this right now, but if you have questions or want to keep an eye on your diet, a quick conversation with your pharmacist or doctor is the right place to start.
References (1)
- Kuo SM, Lin CP, Morehouse HF Jr. Dihydropyridine calcium channel blockers inhibit ascorbic acid accumulation in human intestinal Caco-2 cells. Life Sci 2001;68:1751-60.. PubMed
Nifedipine
Insufficient EvidenceBrand names include Procardia XL, Adalat PA, Adalat
DCCBs inhibit uptake of vitamin C by intestinal cells in vitro. Whether this causes a clinically significant reduction in vitamin C absorption in humans is not known.
Vitamin C is something your body depends on for healthy skin, wound healing, and a strong immune system. Nifedipine belongs to a drug class that, in laboratory studies, appears to interfere with how intestinal cells take up vitamin C, which could theoretically reduce how much you absorb. That said, this has only been seen in lab settings, not confirmed in people, so the real-world impact is simply not known yet. If you take nifedipine long-term and have concerns, it is worth a quick conversation with your pharmacist or doctor.
References (1)
- Kuo SM, Lin CP, Morehouse HF Jr. Dihydropyridine calcium channel blockers inhibit ascorbic acid accumulation in human intestinal Caco-2 cells. Life Sci 2001;68:1751-60.. PubMed
Nisoldipine
Insufficient EvidenceBrand names include Sular
DCCBs inhibit uptake of vitamin C by intestinal cells in vitro. Whether this causes a clinically significant reduction in vitamin C absorption in humans is not known.
Nisoldipine belongs to a drug class that, in lab studies, appears to interfere with how intestinal cells take up vitamin C, the nutrient your immune system and skin tissues depend on for repair and defense. That said, whether this actually translates into lower vitamin C levels in real people is genuinely unknown, so the evidence here is too thin to draw firm conclusions. For most people taking nisoldipine, this is not something to worry about right now, but if you have questions about your diet or whether a supplement makes sense for you, it is worth a quick conversation with your pharmacist or doctor.
References (1)
- Kuo SM, Lin CP, Morehouse HF Jr. Dihydropyridine calcium channel blockers inhibit ascorbic acid accumulation in human intestinal Caco-2 cells. Life Sci 2001;68:1751-60.. PubMed
Nitrendipine
Insufficient EvidenceBrand names include Cardif
DCCBs inhibit uptake of vitamin C by intestinal cells in vitro. Whether this causes a clinically significant reduction in vitamin C absorption in humans is not known.
Nitrendipine belongs to a class of blood pressure medications that, in lab studies, appears to interfere with how intestinal cells take up vitamin C, the nutrient your immune system and skin tissue depend on. That said, this has only been seen in cell studies, not in people, so nobody knows yet whether it actually lowers vitamin C levels in real-world use. Given the 'insufficient evidence' rating, there is no reason to worry right now, but if you are a long-term user of this medication and have concerns, it is worth raising with your pharmacist or doctor.
References (1)
- Kuo SM, Lin CP, Morehouse HF Jr. Dihydropyridine calcium channel blockers inhibit ascorbic acid accumulation in human intestinal Caco-2 cells. Life Sci 2001;68:1751-60.. PubMed
Omeprazole
Insufficient EvidenceBrand names include Prilosec, Zegerid, Losec
Preliminary research suggests omeprazole reduces vitamin C levels, possibly due to increased destruction of vitamin C at higher gastric pH levels. It is not known if this interaction results in clinically significant reductions in vitamin C levels.
Vitamin C is something your body needs to heal tissue, support your immune system, and absorb iron properly. Here is something interesting: omeprazole works by raising the pH inside your stomach, and some early research hints that vitamin C may break down more quickly in a less acidic environment, which could nudge levels a bit lower. That said, the evidence right now is too thin to know whether this actually matters in real life. If you take omeprazole long-term and have concerns, it is worth mentioning to your pharmacist or doctor.
References (1)
- Mowat C, Carswell A, Wirz A, McColl KE. Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice. Gastroenterology 1999;116:813-22. PubMed
Omeprazole, Sodium Bicarbonate
Insufficient EvidenceBrand names include Konvomep
Preliminary research suggests omeprazole reduces vitamin C levels, possibly due to increased destruction of vitamin C at higher gastric pH levels. It is not known if this interaction results in clinically significant reductions in vitamin C levels.
Vitamin C is something your body needs to support your immune system, heal tissue, and absorb iron properly. Omeprazole works by raising the pH inside your stomach, and there is early research suggesting that a less acidic stomach environment may break down vitamin C before it can be absorbed. That said, the evidence here is quite preliminary, and whether this leads to any real shortage in most people is simply not known yet. If you have been on this medication long-term and are curious, it is worth a quick conversation with your pharmacist or doctor.
References (1)
- Mowat C, Carswell A, Wirz A, McColl KE. Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice. Gastroenterology 1999;116:813-22. PubMed
Pantoprazole
Insufficient EvidenceBrand names include Protonix, Pantoloc, Protonix IV
Preliminary research suggests omeprazole reduces vitamin C levels, possibly due to increased destruction of vitamin C at higher gastric pH levels. It is not known if this interaction results in clinically significant reductions in vitamin C levels.
Pantoprazole reduces stomach acid, and there is early research suggesting that less acid in the stomach may actually speed up the breakdown of vitamin C before your body can absorb it. Vitamin C is something your body depends on for immune defense, wound healing, and keeping tissues strong. That said, the evidence here is preliminary and the clinical significance is simply not known, so this is more of a 'keep it on your radar' finding than a cause for concern. If you take pantoprazole long-term and eat a varied diet, you are likely fine, but it is worth mentioning to your pharmacist or doctor if you have questions.
References (1)
- Mowat C, Carswell A, Wirz A, McColl KE. Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice. Gastroenterology 1999;116:813-22. PubMed
Perindopril Arginine, Amlodipine
Insufficient EvidenceBrand names include Prestalia
DCCBs inhibit uptake of vitamin C by intestinal cells in vitro. Whether this causes a clinically significant reduction in vitamin C absorption in humans is not known.
Amlodipine belongs to a class of blood pressure medications that, in lab studies, appears to interfere with how intestinal cells take up vitamin C, a nutrient your immune system, skin, and tissue repair all depend on. That said, nobody has confirmed this actually plays out in real people at meaningful levels, so the evidence right now is simply too thin to know whether it matters. Most people on amlodipine do not need to worry about this, but if you are curious or have concerns about your vitamin C intake, it is worth a quick conversation with your pharmacist or doctor.
References (1)
- Kuo SM, Lin CP, Morehouse HF Jr. Dihydropyridine calcium channel blockers inhibit ascorbic acid accumulation in human intestinal Caco-2 cells. Life Sci 2001;68:1751-60.. PubMed
Rabeprazole
Insufficient EvidenceBrand names include Pariet
Preliminary research suggests omeprazole reduces vitamin C levels, possibly due to increased destruction of vitamin C at higher gastric pH levels. It is not known if this interaction results in clinically significant reductions in vitamin C levels.
Vitamin C is something your body counts on for immune defense, wound healing, and keeping tissues strong. Rabeprazole raises the pH inside your stomach, meaning the stomach becomes less acidic, and some early research hints that vitamin C breaks down more easily in that less-acidic environment. That said, the evidence here is quite preliminary and the real-world impact on your vitamin C levels is genuinely unknown. If you have questions or take rabeprazole long-term, it is worth mentioning to your pharmacist or doctor.
References (1)
- Mowat C, Carswell A, Wirz A, McColl KE. Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice. Gastroenterology 1999;116:813-22. PubMed
Rabeprazole Sodium
Insufficient EvidenceBrand names include Aciphex, Aciphex Sprinkle
Preliminary research suggests omeprazole reduces vitamin C levels, possibly due to increased destruction of vitamin C at higher gastric pH levels. It is not known if this interaction results in clinically significant reductions in vitamin C levels.
Rabeprazole belongs to a class of acid-reducing medicines, and there is some early research suggesting these drugs may lower vitamin C levels, possibly because vitamin C breaks down more easily when stomach acid is reduced. That said, the evidence here is quite thin and no one knows yet whether this translates into a real problem for people taking the drug. If you have been on rabeprazole for a long time and are curious, it is worth mentioning to your pharmacist or doctor at your next visit.
References (1)
- Mowat C, Carswell A, Wirz A, McColl KE. Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice. Gastroenterology 1999;116:813-22. PubMed
Telmisartan, Amlodipine
Insufficient EvidenceBrand names include Twynsta
DCCBs inhibit uptake of vitamin C by intestinal cells in vitro. Whether this causes a clinically significant reduction in vitamin C absorption in humans is not known.
Amlodipine belongs to a drug class that, in lab studies, appears to interfere with how intestinal cells take up vitamin C, the nutrient your immune system, skin, and tissue repair all depend on. That said, whether this actually reduces vitamin C levels in real patients has never been clearly shown, so the evidence right now is simply too thin to draw conclusions. Most people taking this combination do not need to worry, but if you have concerns about your vitamin C intake, a quick conversation with your pharmacist or doctor is always a reasonable step.
References (1)
- Kuo SM, Lin CP, Morehouse HF Jr. Dihydropyridine calcium channel blockers inhibit ascorbic acid accumulation in human intestinal Caco-2 cells. Life Sci 2001;68:1751-60.. PubMed
Trandolapril, Verapamil
Insufficient EvidenceBrand names include Tarka
DCCBs inhibit uptake of vitamin C by intestinal cells in vitro. Whether this causes a clinically significant reduction in vitamin C absorption in humans is not known.
Vitamin C is something your immune system, skin, and wound healing all depend on, so it is worth knowing that verapamil, a calcium channel blocker in this combination, has shown in lab studies an ability to interfere with how intestinal cells take up vitamin C. That said, this has only been seen in lab settings and has not been confirmed to matter in real people, which is why the evidence is currently rated as insufficient. Most patients taking this medication do not need to act on this, but if you have any concerns about your vitamin C levels or diet, it is a good topic to raise with your pharmacist or doctor.
References (1)
- Kuo SM, Lin CP, Morehouse HF Jr. Dihydropyridine calcium channel blockers inhibit ascorbic acid accumulation in human intestinal Caco-2 cells. Life Sci 2001;68:1751-60.. PubMed
Verapamil
Insufficient EvidenceBrand names include Isoptin SR, Verelan, Isoptin
DCCBs inhibit uptake of vitamin C by intestinal cells in vitro. Whether this causes a clinically significant reduction in vitamin C absorption in humans is not known.
Vitamin C is something your immune system, skin, and tissues depend on to stay healthy and repair themselves. Lab studies have suggested that calcium channel blockers like verapamil might interfere with how intestinal cells take up vitamin C, but this has only been shown in a test tube, not in real patients. Honestly, the evidence here is too thin to know whether it matters at all in practice. If you have been on verapamil long-term and are curious, it is worth a quick conversation with your pharmacist or doctor just to put your mind at ease.
References (1)
- Kuo SM, Lin CP, Morehouse HF Jr. Dihydropyridine calcium channel blockers inhibit ascorbic acid accumulation in human intestinal Caco-2 cells. Life Sci 2001;68:1751-60.. PubMed
This tool is educational and is not a substitute for professional medical advice. An association is not a diagnosis and does not mean a deficiency will occur. Always talk to your pharmacist or healthcare provider before starting, stopping, or changing any medication or supplement.
Disclaimer: This checker finds which nutrients might be depleted by prescription or over-the-counter medications. Each nutrient depletion issue is rated based on clinical significance. Use your own professional judgment prior to making clinical decisions.© 2026 Therapeutic Research Center Licensed records refresh weekly · last updated July 3, 2026.
What drug-induced nutrient depletion means
Some medications can, over time, lower the levels of certain vitamins, minerals, or other nutrients — through reduced absorption, increased loss, or changes in how the body uses them.
Association is not deficiency
An entry here means a depletion has been reported or studied — not that it happens to everyone, or that you are deficient. Dose, duration, diet, and your own health all matter.
Evidence varies by pair
Some drug–nutrient links (like metformin and vitamin B12) are well studied; others rest on limited or preliminary research. Each entry shows the evidence rating from our licensed clinical database.
When to ask about labs
If you take an associated medication long-term, ask your healthcare provider whether monitoring is appropriate for you. Not everyone needs testing — your provider can weigh your dose, duration, and symptoms.
Don't self-supplement blindly
Supplements are not risk-free: some can interact with medications, and some (like potassium or magnesium) can be risky with kidney disease. Talk to your pharmacist before adding anything.
Never stop a medication over this
These medications are prescribed for good reasons, and the benefit usually far outweighs a manageable nutrient consideration. Any change belongs in a conversation with your prescriber.
Food first, usually
For many nutrients, a varied diet covers the gap. Each entry lists common food sources; a supplement is a decision to make with your pharmacist or provider, not a default.
VITAMIN C & medications: FAQs
Which medications can lower VITAMIN C?
I take one of these medications — am I deficient in VITAMIN C?
Should I start a VITAMIN C supplement?
Where does this information come from?
Other commonly implicated nutrients
Wondering about your VITAMIN C levels?
Ask a licensed pharmacist — free, no appointment needed.
Sources & How We Checked
Medication associations with VITAMIN C are evidence-graded and sourced from the Natural Medicines database, and are displayed as published with their citations.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for drug-induced nutrient depletions, supplements, and interactions — the basis for this page.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for medication overviews across the site.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.