Drug-induced nutrient depletion

Medications That May Deplete COENZYME Q10

CoQ10 helps cells produce energy and acts as an antioxidant; heart and muscle tissue use it heavily. See which medications carry a reported association, how strong the evidence is, and what to discuss with your pharmacist.

288Medications
288Depletion records
About COENZYME Q10

CoQ10 helps cells produce energy and acts as an antioxidant; heart and muscle tissue use it heavily.

Common food sources: Organ meats and fatty fish; Whole grains; Nuts and seeds.

There is no routine blood test for CoQ10 in everyday practice. If you have new, unexplained muscle symptoms on a medication linked to CoQ10 (statins are the best-known example), talk to your prescriber before changing anything — symptoms have many possible causes and your prescriber has several options.

Caution: Do not stop a prescribed medication because of this association — discuss any symptoms with your prescriber first.

HelloPharmacist pharmacist-reviewed education. The medication records below are licensed clinical data, shown as published.

Deep dive: Coenzyme Q10 — uses, safety & drug interactions

The evidence

Medications associated with COENZYME Q10 depletion

Each record is shown as published in our licensed clinical database. Open a medication for its full nutrient report.

Acarbose

Insignificant Depletion

Brand names include Precose, Prandase, Glucobay

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Acarbose? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and some diabetes medications have been linked to modest reductions in the body's own levels of it. Acarbose works differently from drugs like metformin or sulfonylureas, and the evidence connecting it specifically to coenzyme Q10 changes is not strong. For most people, this is rated as insignificant, meaning a supplement is not considered necessary. That said, if you have questions about your overall diabetes management, your pharmacist or doctor is a great resource.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Acarbose →

Acetohexamide

Insignificant Depletion

Brand names include Dymelor

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Acetohexamide? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and acetohexamide belongs to the sulfonylurea class of diabetes drugs that may modestly interfere with the enzyme activity your body needs to make it. That said, the evidence here is rated insignificant, meaning most people taking this medication are unlikely to notice any real-world effect from it. There is no strong proof that lower coenzyme Q10 levels cause side effects in people on these drugs, and taking a supplement has not been shown to improve blood sugar control either. If you still have questions, a quick chat with your pharmacist can help put your mind at ease.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Acetohexamide →

Albiglutide

Insignificant Depletion

Brand names include Tanzeum

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Albiglutide? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a substance your body makes naturally that helps your cells produce energy and acts as an antioxidant. Some antidiabetes medications have been linked to modest dips in coenzyme Q10 levels, though the connection to albiglutide specifically is not well established, and the overall evidence is rated insignificant. Most people taking albiglutide do not need to worry about this or take a supplement. If you have questions about your own situation, your pharmacist or doctor is the right person to ask.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Albiglutide →

Alogliptin

Insignificant Depletion

Brand names include Nesina

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Alogliptin? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and some antidiabetes medications have been linked to modest reductions in the body's own supply of it. Alogliptin belongs to a different class than the drugs most studied for this effect, so any connection is not well established. The rating here is insignificant, meaning most people taking alogliptin have nothing to worry about and a supplement is not likely needed. That said, if you have questions or feel something is off, it is always worth a quick conversation with your pharmacist or doctor.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Alogliptin →

Alogliptin, Metformin

Insignificant Depletion

Brand names include Kazano

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Alogliptin, Metformin? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and some research suggests metformin may mildly interfere with the enzyme activity involved in making it. That said, the effect appears to be small, and there is no solid evidence it causes meaningful problems or that taking a supplement improves blood sugar control. For most people on this combination, this is not something that requires action. If you are curious about your levels or whether a supplement makes sense for you personally, a quick conversation with your pharmacist or doctor can help.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Alogliptin, Metformin →

Alogliptin, Pioglitazone

Insignificant Depletion

Brand names include Oseni

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Alogliptin, Pioglitazone? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and some antidiabetes medications have been associated with modest reductions in the body's own levels of it. Alogliptin and pioglitazone belong to a different class than the drugs most studied for this effect, so the concern here is considered insignificant for most people taking this combination. There is also no strong evidence that topping up coenzyme Q10 with a supplement actually improves blood sugar control. Most people taking these medications do not need to do anything about this, but if you have questions, your pharmacist or doctor is a great place to start.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Alogliptin, Pioglitazone →

Brand names include Glyxambi

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your body makes that helps cells produce energy, and some research suggests certain diabetes medications, including DPP-4 inhibitors, may modestly reduce how much your body produces on its own. That said, the evidence here is rated insignificant, meaning this is not considered a real-world concern for most people taking this class of drug. There is no strong proof that lower CoQ10 levels from these medications cause any noticeable problems, and taking a CoQ10 supplement has not been shown to improve blood sugar control in people with diabetes. If you are curious whether any supplement makes sense for your situation, your pharmacist or doctor is a good person to ask.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor →

Canagliflozin

Insignificant Depletion

Brand names include Invokana

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Canagliflozin? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. Some antidiabetes medications have been linked to mildly lower levels of it, though the exact way canagliflozin might affect coenzyme Q10 is not well established for this specific drug. The good news is that this is rated as an insignificant depletion, meaning most people taking canagliflozin are unlikely to need a supplement. If you have questions or any concerns, it is always worth a quick chat with your pharmacist or doctor.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Canagliflozin →

Canagliflozin, Metformin

Insignificant Depletion

Brand names include Invokamet

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Canagliflozin, Metformin? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Metformin appears to interfere with certain enzyme activity involved in how the body makes CoQ10 on its own, which can nudge those internal levels down a bit. That said, this combination is rated as insignificant depletion, meaning most people taking these medications do not need to worry about it or reach for a supplement. If you are still curious, it is worth a quick conversation with your pharmacist or doctor.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Canagliflozin, Metformin →

Canagliflozin, Metformin Hydrochloride

Insignificant Depletion

Brand names include Invokamet XR

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Canagliflozin, Metformin Hydrochloride? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Metformin appears to interfere with certain enzymes involved in the body's own CoQ10 production, which may modestly reduce internal levels over time. That said, the evidence here is rated insignificant, meaning most people on this combination do not need to worry or consider a supplement. If you are curious, it is worth a quick conversation with your pharmacist or doctor.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Canagliflozin, Metformin Hydrochloride →

Chlorpropamide

Insignificant Depletion

Brand names include Diabinese, Chlorpropam

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Chlorpropamide? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and chlorpropamide, like other sulfonylurea diabetes medicines, may slightly interfere with the enzymes that make it. That said, the evidence here is modest, and this is rated as an insignificant depletion, meaning most people taking chlorpropamide do not need to worry about it or take a supplement. If you are curious whether coenzyme Q10 is relevant for you personally, it is worth a quick conversation with your pharmacist or doctor.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Chlorpropamide →

Dapagliflozin

Insignificant Depletion

Brand names include Farxiga

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Dapagliflozin? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Some antidiabetes medications have been linked to modest dips in the body's own CoQ10 levels, possibly by interfering with the enzymes that make it, though the evidence for dapagliflozin specifically is not well established. The good news is that this is rated insignificant for most people, and research so far has not shown that taking a CoQ10 supplement actually improves blood sugar control. If you are curious whether any of this applies to you personally, it is worth a quick conversation with your pharmacist or doctor.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Dapagliflozin →

Dapagliflozin Propanediol, Metformin

Insignificant Depletion

Brand names include Xigduo XR

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Dapagliflozin Propanediol, Metformin? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. Metformin appears to modestly interfere with enzymes involved in making CoQ10 naturally in the body, which can nudge levels down slightly. That said, the evidence here is rated insignificant, meaning most people on this combination do not need to worry or take a supplement. If you are curious about your CoQ10 status, it is worth a quick conversation with your pharmacist or doctor.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Dapagliflozin Propanediol, Metformin →

Brand names include Qtern

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Dapagliflozin Propanediol, Saxagliptin Hydrochloride? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is something your body makes naturally to help cells produce energy, and some diabetes medications have been reported to modestly lower those internal levels. Dapagliflozin and saxagliptin are newer diabetes drugs, and the concern here is more tied to older agents like metformin and sulfonylureas, so the effect with this combination is considered insignificant for most people. Research also has not shown that taking a CoQ10 supplement improves blood sugar control in people with diabetes. Unless your doctor or pharmacist flags a specific concern for you, no action is needed here.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Dapagliflozin Propanediol, Saxagliptin Hydrochloride →

Brand names include Qternmet XR

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Metformin, one of the medications in this combination, has been shown to modestly interfere with CoQ10 enzyme activity, which can nudge levels down slightly. That said, the evidence rates this as insignificant for most people, and research so far has not found that taking CoQ10 supplements improves blood sugar control. No action is needed for the majority of patients, but if you have questions about your nutrient levels, your pharmacist or doctor is a great place to start.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride →

Dasiglucagon Hydrochloride

Insignificant Depletion

Brand names include Zegalogue

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Dasiglucagon Hydrochloride? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it may also act as an antioxidant. Some antidiabetes drugs have been linked to modest decreases in the body's own CoQ10 levels, likely by interfering with the enzymes that make it. That said, dasiglucagon is used only for severe low blood sugar episodes rather than as a daily diabetes medicine, so this interaction is considered insignificant for most people. No action is needed, but feel free to bring it up with your pharmacist or doctor if you have questions.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Dasiglucagon Hydrochloride →

Dulaglutide

Insignificant Depletion

Brand names include Trulicity

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Dulaglutide? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. Some antidiabetes medications have been linked to modest dips in the body's own CoQ10 levels, though dulaglutide is not one of the drugs where this has been well studied. The overall evidence rates this as insignificant, meaning most people taking dulaglutide are not expected to need a CoQ10 supplement. If you are curious whether it is relevant for you personally, it is worth a quick chat with your pharmacist or doctor.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Dulaglutide →

Empagliflozin

Insignificant Depletion

Brand names include Jardiance

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Empagliflozin? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and some antidiabetes medications have been associated with modest dips in the body's own levels of it. For empagliflozin specifically, the evidence for any meaningful reduction is quite thin, and researchers have not found a clear, well-established reason it would interfere with coenzyme Q10 the way some older diabetes drugs might. Given the insignificant rating here, most people taking empagliflozin do not need to worry about this or reach for a supplement. If you still have questions, your pharmacist or doctor is a great place to start.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Empagliflozin →

Brand names include Trijardy XR

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Empagliflozin, Linagliptin, Metformin Hydrochloride? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and some research suggests metformin (one of the ingredients in this combination medication) may modestly interfere with the enzymes that make it. That said, the effect appears to be small, and there is no solid evidence that it causes real problems or that taking a CoQ10 supplement actually helps people on these medications. For most patients, this is not something that needs action, but if you are curious or have concerns, your pharmacist or doctor is a good person to ask.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Empagliflozin, Linagliptin, Metformin Hydrochloride →

Empagliflozin, Metformin

Insignificant Depletion

Brand names include Synjardy

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Empagliflozin, Metformin? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Metformin has been shown to mildly interfere with the enzyme activity involved in making coenzyme Q10 in the body, which can nudge levels down a bit. That said, the evidence here is rated insignificant, meaning most people on this combination do not need to worry about it or take a supplement. If you are still curious, a quick conversation with your pharmacist or doctor can help you decide whether anything extra makes sense for you.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Empagliflozin, Metformin →

Empagliflozin, Metformin Hydrochloride

Insignificant Depletion

Brand names include Synjardy XR

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Empagliflozin, Metformin Hydrochloride? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. The metformin in this combination has been shown to mildly interfere with the enzyme activity your body uses to make its own CoQ10, which can nudge levels slightly lower over time. That said, this is rated insignificant, meaning most people on this medication do not need to worry about it or take a supplement. If you are curious whether CoQ10 is relevant for you personally, it is worth a quick conversation with your pharmacist or doctor.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Empagliflozin, Metformin Hydrochloride →

Ertugliflozin

Insignificant Depletion

Brand names include Steglatro

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Ertugliflozin? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and some antidiabetes medications have been linked to modest dips in the body's own levels of it. Ertugliflozin belongs to a different drug class than metformin or sulfonylureas, and there is no strong evidence that it specifically affects coenzyme Q10 in a meaningful way. For most people taking ertugliflozin, this is considered an insignificant concern, and a supplement is not something most patients need. That said, if you are curious about your levels or want to talk it through, your pharmacist or doctor is a good starting point.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Ertugliflozin →

Ertugliflozin, Metformin Hydrochloride

Insignificant Depletion

Brand names include Segluromet

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Ertugliflozin, Metformin Hydrochloride? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. The metformin component of this combination may gently interfere with the enzyme activity your body uses to make coenzyme Q10, which can nudge levels down slightly. That said, the evidence puts this in the 'insignificant' category, meaning most people taking metformin do not need to worry about it or take a supplement. If you are curious whether this applies to you, it is worth a quick chat with your pharmacist or doctor.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Ertugliflozin, Metformin Hydrochloride →

Exenatide

Insignificant Depletion

Brand names include Byetta, Bydureon

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Exenatide? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Some antidiabetes medications, particularly metformin and sulfonylureas, have been linked to modest dips in the body's own CoQ10 levels, possibly by interfering with the enzymes that make it. Exenatide belongs to a different drug class, so any connection here is quite indirect, and the evidence is rated insignificant. For most people taking exenatide, this is not something that requires action, though your pharmacist is always a good resource if you have questions.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Exenatide →

Exenatide Synthetic

Insignificant Depletion

Brand names include Bydureon BCISE

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Exenatide Synthetic? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Some antidiabetes medications, particularly metformin and sulfonylureas, have been linked to modest dips in CoQ10 levels, possibly by interfering with the enzymes that make it. Exenatide works differently from those drugs, so any connection to CoQ10 is considered insignificant, and most people taking it simply do not need to worry about this. If you are curious about your levels or whether a supplement makes sense for you, a quick chat with your pharmacist or doctor is the best place to start.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Exenatide Synthetic →

Gliclazide

Insignificant Depletion

Brand names include Diamicron

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Gliclazide? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and gliclazide, as a sulfonylurea, has been reported to mildly reduce the body's own levels of it. The working theory is that sulfonylureas may interfere with the enzymes involved in making coenzyme Q10 naturally. That said, this is rated as insignificant depletion, and research has not shown that taking a coenzyme Q10 supplement actually improves blood sugar control in people with diabetes. Most patients on gliclazide do not need to act on this, but if you have questions, your pharmacist or doctor is the right person to ask.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Gliclazide →

Glimepiride

Insignificant Depletion

Brand names include Amaryl

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Glimepiride? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to generate energy, and it also acts as an antioxidant. Glimepiride belongs to a drug class called sulfonylureas, and there is some evidence that sulfonylureas may modestly reduce the body's own CoQ10 levels, possibly by interfering with the enzyme activity needed to make it. That said, the effect appears small and has not been shown to cause real problems, so for most people taking glimepiride, a CoQ10 supplement is not something you need to worry about. If you are curious whether it applies to you personally, it is worth a quick conversation with your pharmacist or doctor.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Glimepiride →

Glipizide

Insignificant Depletion

Brand names include Glucotrol, Glucotrol XL

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Glipizide? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and glipizide (a sulfonylurea) may modestly lower your body's own production of it by interfering with the enzyme activity involved in making it. That said, the evidence rates this as insignificant, meaning most people on glipizide simply do not need to worry about it. Studies also show that taking a CoQ10 supplement does not appear to meaningfully improve blood sugar control anyway. If you still have questions about whether any supplement makes sense for you, your pharmacist or doctor is the right person to ask.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Glipizide →

Glipizide, Metformin

Insignificant Depletion

Brand names include Metaglip

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Glipizide, Metformin? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. Both metformin and sulfonylureas like glipizide appear to interfere with how the body makes or uses CoQ10, which can lead to modestly lower levels over time. That said, the evidence rates this as insignificant for most people, and studies have not shown that taking CoQ10 supplements actually improves blood sugar control. So this is not something most patients need to act on, but if you are curious or have concerns, it is worth a quick conversation with your pharmacist or doctor.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Glipizide, Metformin →

Glucagon

Insignificant Depletion

Brand names include Baqsimi

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Glucagon? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it plays a role in protecting cells from damage. Interestingly, the depletion concern here is really tied to oral antidiabetes drugs like metformin and sulfonylureas, not glucagon itself, since glucagon is given as an injection in emergencies and is not taken regularly the way those medications are. Because of that, and because the evidence for any meaningful drop in coenzyme Q10 is rated insignificant overall, most people receiving glucagon do not need to give this a second thought. If you have questions about coenzyme Q10 and any diabetes medications you take daily, it is worth a quick conversation with your pharmacist.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Glucagon →

Glucose

Insignificant Depletion

Brand names include IV Glucose

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Glucose? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and some antidiabetes medications like metformin and sulfonylureas have been reported to modestly lower the body's own CoQ10 levels, possibly by interfering with an enzyme involved in making it. That said, the evidence here is rated insignificant, meaning most people taking these medications do not appear to need a CoQ10 supplement, and taking one has not been shown to improve blood sugar control. If you still have questions, your pharmacist is a great first stop.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Glucose →

Glyburide

Insignificant Depletion

Brand names include Diabeta, Micronase, Glynase

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Glyburide? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and glyburide (a sulfonylurea) has been associated with modest reductions in the body's own CoQ10 levels, possibly by interfering with the enzyme activity involved in making it. That said, the evidence rates this as an insignificant depletion, meaning most people taking glyburide are unlikely to notice any real-world impact. Research so far has not shown that taking a CoQ10 supplement improves blood sugar control in people with diabetes, so this is not something most patients need to act on. If you are still curious, it is always fine to bring it up with your pharmacist or doctor.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Glyburide →

Glyburide, Metformin

Insignificant Depletion

Brand names include Glucovance

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Glyburide, Metformin? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and both metformin and glyburide appear to modestly interfere with the enzymes that make it. That said, the effect is considered insignificant for most people, and there is no solid evidence this small dip causes any real problems or that taking a CoQ10 supplement improves blood sugar control. Most patients on these medications do not need to do anything about this, but if you have questions, your pharmacist or doctor is a great place to start.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Glyburide, Metformin →

Inhaled Insulin

Insignificant Depletion

Brand names include Exubera

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Inhaled Insulin? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and some antidiabetes drugs have been linked to modest dips in the body's own supply. Inhaled insulin itself is not the drug tied to this effect in the research; it is oral agents like metformin and sulfonylureas that appear to interfere with CoQ10 enzyme activity. Because the rating here is insignificant, this is not something most people need to act on, and adding a CoQ10 supplement has not been shown to improve blood sugar control anyway. If you have questions about your specific regimen, a quick chat with your pharmacist is always a good starting point.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Inhaled Insulin →

Insulin

Insignificant Depletion

Brand names include NovoRapid Insulin

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Insulin? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. The evidence linking insulin specifically to lower CoQ10 levels is not well established; the more studied connection involves other diabetes drugs like metformin and sulfonylureas. Given that this is rated as insignificant depletion, most people using insulin do not need to worry about this or consider a CoQ10 supplement. If you have questions about your nutritional needs while managing diabetes, your pharmacist or doctor is a great place to start.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Insulin →

Insulin (Bovine)

Insignificant Depletion

Brand names include Hypurin Bovine Neutral

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Insulin (Bovine)? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Some antidiabetes medications have been loosely linked to modest dips in CoQ10 levels, though the connection with bovine insulin specifically is not well established. The evidence here is rated insignificant, meaning this is not something most people using insulin need to worry about, and routine CoQ10 supplementation is generally not recommended. If you have questions about your nutritional needs while managing diabetes, your pharmacist or doctor is the right person to ask.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Insulin (Bovine) →

Insulin (Human)

Insignificant Depletion

Brand names include Novolin N, Novolin 70/30, Novolin R

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Insulin (Human)? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a substance your cells use to produce energy, and it also acts as an antioxidant. Some antidiabetes drugs like metformin and sulfonylureas have been linked to modest dips in CoQ10 levels, but insulin itself is not well known for this effect, and the overall concern is rated insignificant. Research so far has not shown that taking CoQ10 supplements improves blood sugar control in people with diabetes, so most patients on insulin do not need to worry about this or take any action beyond their current routine.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Insulin (Human) →

Insulin (Pork)

Insignificant Depletion

Brand names include Lente Iletin II, NPH Iletin, Regular Iletin

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Insulin (Pork)? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and some antidiabetes medications have been loosely linked to modest dips in its natural levels. For insulin specifically, this connection is not well established, and the evidence rating here is insignificant, meaning most people using pork insulin simply do not need to worry about it. Research so far has not shown that taking a CoQ10 supplement improves blood sugar control in people with diabetes. If you are curious whether this applies to your situation, it is worth a quick conversation with your pharmacist or doctor.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Insulin (Pork) →

Insulin (rDNA)

Insignificant Depletion

Brand names include Humalog, Humalog Mix 75/25, Humulin R

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Insulin (rDNA)? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. The concern with certain antidiabetes drugs is that they may interfere with enzymes involved in making CoQ10 naturally, but the evidence for insulin specifically is quite thin, and the overall rating here is insignificant. In plain terms, most people using insulin do not need to worry about this or consider a CoQ10 supplement. If you have questions about your nutritional needs while managing diabetes, your pharmacist or doctor is a great place to start.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Insulin (rDNA) →

Insulin Aspart

Insignificant Depletion

Brand names include Fiasp

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Insulin Aspart? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a naturally made compound your cells use to produce energy, and some antidiabetes medications have been linked to modest dips in the body's own levels of it. With insulin aspart specifically, this connection is not well established, and the overall evidence for any meaningful depletion is considered insignificant. For most people using this insulin, there is no reason to worry or to start a CoQ10 supplement. That said, if you have questions about your nutrient levels or supplements, your pharmacist or doctor is the right person to ask.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Insulin Aspart →

Insulin Aspart, Insulin Degludec

Insignificant Depletion

Brand names include Ryzodeg 70/30

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Insulin Aspart, Insulin Degludec? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Interestingly, the depletion concern here comes mainly from other diabetes drugs like metformin and sulfonylureas, not from insulin itself. Since insulin aspart and insulin degludec don't share those same mechanisms, and even for the drugs where a modest effect has been reported the evidence hasn't shown meaningful harm, this is rated insignificant for most patients. No action is needed, but if you have questions your pharmacist is always a good place to start.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Insulin Aspart, Insulin Degludec →

Insulin Degludec

Insignificant Depletion

Brand names include Tresiba

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Insulin Degludec? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and some antidiabetes drugs have been linked to modest dips in the body's own levels of it. Insulin degludec itself is not strongly associated with this effect; the concern comes mainly from other diabetes medicines like metformin or sulfonylureas. Even then, the evidence is rated insignificant, meaning most people do not need a supplement, and taking extra coenzyme Q10 has not been shown to improve blood sugar control. No action is needed on your part, but if you have questions about your overall diabetes regimen, your pharmacist or doctor is a great person to ask.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Insulin Degludec →

Insulin Degludec, Liraglutide

Insignificant Depletion

Brand names include Xultophy 100/3.6

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Insulin Degludec, Liraglutide? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your body makes that helps cells produce energy and acts as an antioxidant. Some antidiabetes medications have been linked to modest reductions in coenzyme Q10 levels, though the evidence for insulin degludec and liraglutide specifically is not strong, and this combination is rated as insignificant depletion. The good news is that research has not shown a clear connection between lower coenzyme Q10 levels and side effects from these types of drugs, and CoQ10 supplements do not appear to meaningfully improve blood sugar control. For most people taking these medications, no action is needed, but feel free to ask your pharmacist if you have questions.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Insulin Degludec, Liraglutide →

Insulin determir

Insignificant Depletion

Brand names include Levemir

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Insulin determir? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and some antidiabetes medications have been loosely linked to modest dips in the body's own levels of it. For insulin detemir specifically, any effect on coenzyme Q10 appears to be quite small, and the overall evidence is not convincing that it causes a meaningful shortfall. Most people using this insulin do not need to take a coenzyme Q10 supplement, and research so far does not show that taking one improves blood sugar control anyway. If you have questions about your nutritional needs, your pharmacist or doctor is the right person to ask.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Insulin determir →

Insulin Glargine

Insignificant Depletion

Brand names include Basaglar, Lusduna, Semglee

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Insulin Glargine? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and some antidiabetes medications have been linked to modest reductions in the body's own levels of it. Insulin glargine itself is not strongly tied to this effect, and the research connection is mostly noted with other diabetes drugs like metformin and sulfonylureas. Given the insignificant rating here, this is not something most people using insulin glargine need to worry about, but if you have questions about your overall diabetes regimen, it is always worth a conversation with your pharmacist or doctor.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Insulin Glargine →

Insulin Glargine (rDNA)

Insignificant Depletion

Brand names include Lantus

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Insulin Glargine (rDNA)? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and some antidiabetes medications have been linked to modest dips in its levels. For insulin glargine specifically, the connection is indirect and not well established, and the overall evidence is rated insignificant, meaning most people on this medication are very unlikely to need a supplement. There is also no solid proof that taking extra coenzyme Q10 improves blood sugar control in people with diabetes. That said, if you are curious about your levels or wondering whether a supplement makes sense for you, it is always worth a quick conversation with your pharmacist or doctor.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Insulin Glargine (rDNA) →

Insulin Glargine Recombinant

Insignificant Depletion

Brand names include Toujeo Solostar

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Insulin Glargine Recombinant? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and some antidiabetes medications have been loosely linked to modest dips in the body's own levels of it. For insulin glargine specifically, any connection is not well established, and the evidence rating here is insignificant, meaning this is more of a theoretical footnote than a real concern for most people using this insulin. Research so far has not shown that taking a CoQ10 supplement improves blood sugar control in people with diabetes. If you have questions about whether a supplement makes sense for your situation, your pharmacist or doctor is the right person to ask.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Insulin Glargine Recombinant →

Insulin Glargine, Lixisenatide

Insignificant Depletion

Brand names include Soliqua 100/33

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Insulin Glargine, Lixisenatide? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Some antidiabetes medications have been linked to modest reductions in CoQ10 levels, though this combination of insulin glargine and lixisenatide is not among the drugs where that connection is well established. The evidence here is rated insignificant, meaning most people on this regimen do not need to worry about CoQ10 or consider a supplement. If you are curious about your levels or want to talk it through, your pharmacist or doctor is a good place to start.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Insulin Glargine, Lixisenatide →

Insulin Glulisine (rDNA)

Insignificant Depletion

Brand names include Apidra

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Insulin Glulisine (rDNA)? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a naturally made compound your cells use to produce energy, and it also acts as an antioxidant. Some antidiabetes drugs like metformin and sulfonylureas have been linked to modest dips in the body's own CoQ10 levels, but insulin glulisine is not in those drug classes, and any connection to CoQ10 for this insulin is considered insignificant. For most people using insulin glulisine, there is no practical reason to reach for a CoQ10 supplement, though if you have questions about your specific situation, your pharmacist is a great place to start.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Insulin Glulisine (rDNA) →

Insulin Human, Sodium Chloride

Insignificant Depletion

Brand names include Myxredlin

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Insulin Human, Sodium Chloride? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and some antidiabetes medications have been linked to modest dips in its levels. The connection with insulin specifically is not well established, and the overall evidence here is rated insignificant, meaning most people using insulin do not need to worry about this or take a supplement for it. Research so far also has not shown that adding coenzyme Q10 helps blood sugar control in people with diabetes. That said, if you have questions about your personal situation, your pharmacist or doctor is a great place to start.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Insulin Human, Sodium Chloride →

Insulin Lispro

Insignificant Depletion

Brand names include Admelog, Admelog Solostar

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Insulin Lispro? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and some antidiabetes medications have been linked to modest dips in the body's own levels of it. For insulin lispro specifically, there is no well-established mechanism showing it lowers coenzyme Q10, and the overall evidence here is rated insignificant. Research also has not shown that taking coenzyme Q10 supplements improves blood sugar control in people with diabetes, so most patients using insulin lispro do not need to worry about this one. That said, if you have questions about your nutritional needs, your pharmacist or doctor is a great place to start.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Insulin Lispro →

Insulin Lispro Recombinant

Insignificant Depletion

Brand names include Humalog Kwikpen

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Insulin Lispro Recombinant? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and some research suggests certain diabetes medications may slightly reduce the body's own levels of it. With insulin lispro specifically, there is no well-established mechanism showing it directly lowers coenzyme Q10, and the overall evidence here is rated insignificant. For most people using this insulin, this is not a practical concern and supplements are not something you need to seek out on your own. If you are curious, it is always fine to bring it up with your pharmacist or doctor.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Insulin Lispro Recombinant →

Insulin Lispro-Aabc

Insignificant Depletion

Brand names include Lyumjev

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Insulin Lispro-Aabc? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and some diabetes medications have been linked to modest dips in the body's own levels of it. For insulin lispro-aabc specifically, there is no well-established mechanism showing it lowers coenzyme Q10, and the overall evidence is rated insignificant. Most people taking this insulin do not need to worry about this or consider a supplement. If you have questions about your diabetes regimen, your pharmacist or doctor is the right person to ask.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Insulin Lispro-Aabc →

Linagliptin

Insignificant Depletion

Brand names include Tradjenta

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Linagliptin? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Some antidiabetes medications have been linked to modest decreases in the body's own CoQ10 levels, though linagliptin belongs to a newer drug class and the evidence for this effect is not well established for it specifically. The overall rating here is insignificant, meaning most people taking linagliptin are not expected to need a CoQ10 supplement. If you are curious or have concerns, it is worth a quick conversation with your pharmacist or doctor.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Linagliptin →

Linagliptin, Metformin Hydrochloride

Insignificant Depletion

Brand names include Jentadueto XR

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Linagliptin, Metformin Hydrochloride? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Metformin appears to mildly interfere with the enzyme activity your body uses to make its own coenzyme Q10, which may nudge levels slightly lower over time. That said, the evidence rates this as insignificant, and research has not shown that taking a coenzyme Q10 supplement improves blood sugar control in people with diabetes. For most patients on this medication, no action is needed, but feel free to bring it up with your pharmacist or doctor if you are curious.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Linagliptin, Metformin Hydrochloride →

Liraglutide

Insignificant Depletion

Brand names include Victoza

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Liraglutide? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. Liraglutide itself is not strongly linked to lowering CoQ10 levels; the concern in the research is mostly tied to other diabetes medicines like metformin and sulfonylureas. Even in those cases, the drop in CoQ10 is considered insignificant for most people, and there is no solid evidence that taking a CoQ10 supplement improves blood sugar control. For the average person using liraglutide, this is not something that needs action, but your pharmacist is always a good sounding board if you have questions.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Liraglutide →

Liraglutide Recombinant

Insignificant Depletion

Brand names include Saxenda

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Liraglutide Recombinant? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a naturally made compound your cells use to produce energy, and some diabetes medications have been linked to modest dips in the body's own levels of it. Liraglutide is not one of the drugs most associated with this effect; the research pointing to lower CoQ10 levels is mainly tied to metformin and sulfonylureas, not GLP-1 medications like liraglutide. The rating here is insignificant, meaning this is not something most people using liraglutide need to worry about or act on. That said, if you have questions about CoQ10 or any supplement, your pharmacist is a great first stop.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Liraglutide Recombinant →

Lixisenatide

Insignificant Depletion

Brand names include Adlyxin

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Lixisenatide? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your body makes that helps cells produce energy and acts as an antioxidant. Some antidiabetes medications have been linked to modest reductions in CoQ10 levels, though lixisenatide itself is not strongly tied to this effect. The evidence here is rated insignificant, meaning most people taking this medication are very unlikely to need a CoQ10 supplement. That said, if you have questions about your specific situation, your pharmacist or doctor is a great person to ask.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Lixisenatide →

Metformin

Insignificant Depletion

Brand names include Glucophage

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Metformin? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and some research suggests metformin may interfere with an enzyme involved in making it, nudging levels down slightly. That said, this is rated insignificant, meaning the drop is modest and has not been shown to cause real-world problems for most people. Taking a CoQ10 supplement has not been shown to improve blood sugar control in people with diabetes, so there is no clear benefit to adding one. If you are curious whether this applies to you personally, it is worth a quick conversation with your pharmacist or doctor.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Metformin →

Metformin Hydrochloride

Insignificant Depletion

Brand names include Riomet ER

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Metformin Hydrochloride? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your body makes naturally that helps cells produce energy, and some research suggests metformin may modestly reduce its levels by interfering with the enzymes your body uses to make it. That said, the evidence here is rated insignificant, meaning this small dip has not been linked to any real harm in people taking metformin. Most patients on this medication do not need a CoQ10 supplement, and taking one has not been shown to improve blood sugar control. If you are still curious about it, a quick conversation with your pharmacist or doctor can put your mind at ease.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Metformin Hydrochloride →

Metformin XR

Insignificant Depletion

Brand names include Glucophage XR

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Metformin XR? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your body makes that helps cells generate energy, and some research suggests metformin may modestly reduce your body's own production of it, possibly by interfering with the enzymes involved in making it. That said, the evidence here is rated insignificant, meaning this small dip does not appear to cause real problems for most people taking metformin, and studies have not shown that taking a CoQ10 supplement improves blood sugar control. For now, there is no strong reason to add one, but if you have questions or concerns, your pharmacist or doctor is a good place to start.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Metformin XR →

Metformin, Linagliptin

Insignificant Depletion

Brand names include Jentadueto

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Metformin, Linagliptin? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Metformin appears to mildly interfere with the enzyme activity your body uses to make its own coenzyme Q10, which can nudge levels slightly lower. That said, the evidence rates this as insignificant, meaning most people on metformin do not need a supplement, and research so far has not shown that taking coenzyme Q10 improves blood sugar control. If you are still curious whether this applies to you personally, it is worth a quick conversation with your pharmacist or doctor.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Metformin, Linagliptin →

Metformin, Rosiglitazone

Insignificant Depletion

Brand names include Avandamet

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Metformin, Rosiglitazone? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and some research suggests metformin may mildly interfere with the enzymes that make it. That said, the dip in levels seen in studies is considered insignificant, meaning most people taking metformin or rosiglitazone have no reason for concern about this. Adding a CoQ10 supplement has not been shown to improve blood sugar control in people with diabetes, so it is not routinely recommended. If you are curious whether it applies to you personally, a quick conversation with your pharmacist or doctor can help.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Metformin, Rosiglitazone →

Metformin, Sitagliptin

Insignificant Depletion

Brand names include Janumet, Janumet XR

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Metformin, Sitagliptin? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and some research suggests metformin may gently interfere with the enzymes involved in making it, which can modestly lower the amount your body produces on its own. That said, the evidence here is rated insignificant, meaning this small dip does not appear to cause real problems for most people taking metformin or sitagliptin. Adding a coenzyme Q10 supplement has not been shown to improve blood sugar control in people with diabetes, so there is no strong reason to start one on your own. If you are curious whether it is worth discussing for your specific situation, your pharmacist or doctor is a great place to start.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Metformin, Sitagliptin →

Miglitol

Insignificant Depletion

Brand names include Glyset

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Miglitol? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and some diabetes medications have been loosely associated with modest dips in the body's own supply. Miglitol works mainly in your gut by slowing carbohydrate digestion, so any effect on coenzyme Q10 levels is considered quite small and not well established for this drug specifically. The evidence rating here is insignificant, meaning this is not something most people taking miglitol need to worry about or act on. That said, if you have questions about your overall supplement routine, your pharmacist or doctor is a good place to start.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Miglitol →

Muraglitazar

Insignificant Depletion

Brand names include Pargluva

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Muraglitazar? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to generate energy, and it also acts as an antioxidant throughout the body. Some antidiabetes medications in the same class as muraglitazar appear to interfere with the enzyme activity that helps your body make its own coenzyme Q10, which can nudge levels down modestly. That said, the evidence here is rated insignificant, meaning most people taking this type of drug do not need a supplement, and coenzyme Q10 supplements have not been shown to meaningfully improve blood sugar control anyway. If you are curious about your levels, a quick conversation with your pharmacist or doctor is the best place to start.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Muraglitazar →

Nateglinide

Insignificant Depletion

Brand names include Starlix

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Nateglinide? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. Some antidiabetes drugs in the sulfonylurea family appear to interfere with the enzymes your body uses to make CoQ10, and nateglinide works in a similar way to those drugs, so a modest effect is plausible. That said, the evidence here is rated insignificant, meaning most people taking nateglinide are unlikely to need a CoQ10 supplement. If you are curious about your levels or whether supplementing makes sense for you, it is worth a quick chat with your pharmacist or doctor.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Nateglinide →

Pioglitazone

Insignificant Depletion

Brand names include Actos

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Pioglitazone? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. Some antidiabetes medications have been linked to modest reductions in the body's own CoQ10 levels, though for pioglitazone specifically the evidence is limited and the overall rating here is insignificant. In plain terms, this is not something most people taking pioglitazone need to worry about, and research so far has not shown that taking a CoQ10 supplement improves blood sugar control. That said, if you have questions or a specific concern, your pharmacist or doctor is a great resource.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Pioglitazone →

pioglitazone, metformin

Insignificant Depletion

Brand names include ActoPlus Met

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking pioglitazone, metformin? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. The metformin component of this combination has been shown to modestly interfere with CoQ10 enzyme activity, which can nudge the body's own levels down a little. That said, the evidence rates this as insignificant for most people, and research has not found that taking CoQ10 supplements improves blood sugar control in people with diabetes. Most patients on this medication do not need to act on this, but if you are curious whether it applies to you, it is worth a quick conversation with your pharmacist or doctor.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for pioglitazone, metformin →

Pramlintide

Insignificant Depletion

Brand names include Symlin

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Pramlintide? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and some antidiabetes medications have been linked to modest reductions in the body's own levels of it. Pramlintide is a newer injectable diabetes medication, and honestly, there is no strong evidence it meaningfully affects coenzyme Q10 on its own. The 'insignificant depletion' rating here means most people using pramlintide do not need to worry about this or consider a supplement. If you have questions about your diabetes medications and nutrition, your pharmacist or doctor is a good place to start.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Pramlintide →

Repaglinide

Insignificant Depletion

Brand names include Prandin, GlucoNorm

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Repaglinide? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and some antidiabetes medications in the sulfonylurea class have been linked to modest reductions in the body's own CoQ10 levels. Repaglinide works differently from those drugs, so any connection to CoQ10 is even less clear. The rating here is insignificant, meaning this is not something most people need to worry about or act on. If you are curious whether a CoQ10 supplement makes sense for you personally, it is worth a quick conversation with your pharmacist or doctor.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Repaglinide →

Rosiglitazone Maleate

Insignificant Depletion

Brand names include Avandia

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Rosiglitazone Maleate? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and some research suggests that certain antidiabetes medications may modestly reduce the body's own supply of it. Rosiglitazone belongs to that same class of drugs, so a similar effect is possible in theory. That said, the evidence here is rated insignificant, meaning this is not considered a clinically meaningful concern for most people taking it, and studies have not shown that adding a CoQ10 supplement improves blood sugar control. If you are curious whether anything applies to your situation, a quick conversation with your pharmacist is always a good idea.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Rosiglitazone Maleate →

rosiglitazone, glimepiride

Insignificant Depletion

Brand names include Avandaryl

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking rosiglitazone, glimepiride? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Sulfonylureas like glimepiride appear to interfere with certain enzymes involved in the body's own CoQ10 production, which can modestly reduce internal levels. That said, the evidence here is rated insignificant, meaning most people taking these diabetes medications do not need to worry about this or take a CoQ10 supplement. If you have questions about your specific situation, your pharmacist or doctor is a good person to ask.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for rosiglitazone, glimepiride →

Saxagliptin

Insignificant Depletion

Brand names include Onglyza

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Saxagliptin? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Some antidiabetes medications have been linked to modest dips in the body's own CoQ10 levels, though the connection with saxagliptin specifically is not well established. Given the insignificant rating here, this is more of a footnote than a real concern for most people, and CoQ10 supplements have not been shown to improve blood sugar control anyway. No action is needed, but your pharmacist is always a good sounding board if you have questions.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Saxagliptin →

Saxagliptin, metformin XR

Insignificant Depletion

Brand names include Kombiglyze

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Saxagliptin, metformin XR? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Research shows metformin may mildly interfere with the enzyme activity your body uses to make coenzyme Q10 on its own, which can nudge levels down slightly. That said, this is rated as insignificant depletion, meaning most people on this combination do not need to worry about it or take a supplement. If you are curious whether this applies to you personally, it is worth a quick conversation with your pharmacist or doctor.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Saxagliptin, metformin XR →

Semaglutide

Insignificant Depletion

Brand names include Ozempic, Rybelsus, Wegovy

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Semaglutide? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and some antidiabetes medications have been linked to modest dips in the body's own supply of it. Semaglutide itself is not well known for this effect; the concern comes mainly from older diabetes drugs like metformin and sulfonylureas, and even with those the evidence is not strong. For most people on semaglutide, this is considered an insignificant finding, meaning a supplement is not something most patients need to think about. That said, if you have questions or want to talk it through, your pharmacist or doctor is always a good place to start.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Semaglutide →

Simvastatin, Sitagliptin

Insignificant Depletion

Brand names include Juvisync

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Simvastatin, Sitagliptin? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. Some antidiabetes medications have been shown to slightly reduce the body's own CoQ10 activity, though the exact reason is not fully understood. For most people taking sitagliptin or simvastatin, this is considered an insignificant concern, meaning routine supplementation is not something most patients need to worry about. If you have questions about your specific situation, your pharmacist or doctor is the best person to ask.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Simvastatin, Sitagliptin →

Sitagliptin

Insignificant Depletion

Brand names include Januvia, Zituvio

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Sitagliptin? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to generate energy, and some antidiabetes medications have been linked to modest dips in the body's natural levels of it. Sitagliptin works differently from older diabetes drugs like metformin or sulfonylureas, so any connection to coenzyme Q10 for sitagliptin specifically is not well established. The evidence here is rated insignificant, meaning most people taking sitagliptin have no reason to worry about this or reach for a supplement. If you have questions about your nutrition while managing diabetes, your pharmacist or doctor is a great place to start.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Sitagliptin →

Sitagliptin, Metformin

Insignificant Depletion

Brand names include Zituvimet

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Sitagliptin, Metformin? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a naturally made compound your cells use to produce energy, and some research suggests metformin may modestly interfere with the enzyme activity involved in making it. That said, this combination carries an insignificant depletion rating, meaning the effect appears small and most people taking these medications do not need to worry about it. Studies so far have not shown that taking a CoQ10 supplement actually improves blood sugar control in people with diabetes. If you have questions about whether a supplement makes sense for your situation, a quick conversation with your pharmacist or doctor is the best next step.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Sitagliptin, Metformin →

Sotagliflozin

Insignificant Depletion

Brand names include Inpefa

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Sotagliflozin? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and some antidiabetes medications have been linked to modest dips in the body's natural levels of it. Sotagliflozin belongs to the SGLT inhibitor class, and while closely related diabetes drugs like metformin and sulfonylureas appear to interfere with CoQ10 enzyme activity, the overall effect is considered insignificant for most patients. Research so far has not shown that lower CoQ10 levels from these medications cause meaningful problems, and taking a CoQ10 supplement does not appear to improve blood sugar control either. For now, most people on sotagliflozin do not need to do anything about this, but feel free to ask your pharmacist if you have questions.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Sotagliflozin →

Tirzepatide

Insignificant Depletion

Brand names include Mounjaro, Zepbound

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Tirzepatide? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and some antidiabetes medications have been linked to modest reductions in the body's natural levels of it. Tirzepatide itself does not have a well-established direct mechanism for this, but because it is used alongside or compared to drugs like metformin that may gently inhibit coenzyme Q10 enzyme activity, the topic sometimes comes up. That said, this interaction is rated insignificant, meaning a supplement is not considered necessary for most people, and there is no strong evidence that tweaking coenzyme Q10 levels meaningfully affects blood sugar control. If you are still curious whether this applies to your situation, a quick chat with your pharmacist or doctor can put your mind at ease.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Tirzepatide →

Tobutamide

Insignificant Depletion

Brand names include Mobenol

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Tobutamide? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it plays a supporting role in heart and muscle function. Tolbutamide, a sulfonylurea used for blood sugar control, may modestly reduce the body's natural coenzyme Q10 levels, possibly by interfering with the enzyme activity involved in making it. That said, the evidence here is rated insignificant, meaning most people taking this medication do not need to worry about supplementing coenzyme Q10. If you have questions about your diabetes medications and nutritional needs, your pharmacist or doctor is the right person to ask.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Tobutamide →

Tolazamide

Insignificant Depletion

Brand names include Tolinase

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Tolazamide? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and tolazamide, like other sulfonylurea diabetes medications, may modestly reduce your body's own CoQ10 levels by interfering with the enzymes that make it. That said, the evidence here is rated insignificant, meaning most people taking tolazamide do not need to worry about this or take a supplement. Research so far has not shown that topping up CoQ10 actually improves blood sugar control anyway. If you have questions or concerns, it is always worth a quick conversation with your pharmacist or doctor.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Tolazamide →

Tolbutamide

Insignificant Depletion

Brand names include Orinase

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Tolbutamide? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Tolbutamide belongs to the sulfonylurea family of diabetes medications, and there is some evidence that drugs in this class can modestly lower the body's own production of coenzyme Q10, a nutrient your cells use to generate energy. The effect appears to involve interfering with the enzyme activity your body needs to make coenzyme Q10 on its own. That said, this is rated as insignificant depletion, meaning the real-world impact for most people taking tolbutamide is considered minimal. No routine supplementation is recommended, but if you have questions or any concerns, your pharmacist or doctor is the right person to ask.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Tolbutamide →

Troglitazone

Insignificant Depletion

Brand names include Rezulin

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Troglitazone? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and some antidiabetes medications have been linked to modest dips in the body's own levels of it. Troglitazone belongs to that class of drugs, so a similar effect is plausible, though the evidence for any meaningful drop is quite thin. For most people, this falls into the "worth knowing but not worth worrying about" category, and a supplement is not considered necessary. If you have questions about your specific situation, your pharmacist or doctor is the right person to ask.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Troglitazone →

Vildagliptin

Insignificant Depletion

Brand names include Galvus

Metformin and sulfonylureas can modestly decrease endogenous levels of coenzyme Q10, but coenzyme Q10 supplements are not likely to be needed for patients taking these drugs.

Some antidiabetes drugs, including metformin and sulfonylureas, appear to inhibit coenzyme Q10 enzyme activity and decrease endogenous levels of coenzyme Q10. However, there is no strong evidence that coenzyme Q10 depletion is the cause of antidiabetes drug-related side effects. Furthermore, taking coenzyme Q10 does not seem to improve fasting glucose levels or glycated hemoglobin in patients with diabetes.
Taking Vildagliptin? A supplement is not needed for most patients.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and some diabetes medications have been linked to modest reductions in the body's own supply of it. Vildagliptin belongs to a class of antidiabetes drugs where this has occasionally been noted, though the exact way it might affect CoQ10 is not well established for this specific medication. The good news is that the evidence rates this as insignificant, meaning most people taking vildagliptin are unlikely to need a CoQ10 supplement. If you are still curious, a quick chat with your pharmacist or doctor can help you decide whether it is worth paying attention to in your situation.

References (4)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
  2. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016;19(8):588-96. doi: 0161908/AIM
  3. Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12. PubMed
  4. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015 Aug;40(4):413-8.

Full nutrient report for Vildagliptin →

Acebutolol

Insufficient Evidence

Brand names include Sectral, Rhotral

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Acebutolol? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your body makes and uses to produce energy inside cells, and it also acts as an antioxidant. Acebutolol is a beta blocker, and there is some evidence that beta blockers may interfere with certain enzymes involved in the body's own CoQ10 production, which could modestly reduce levels over time. That said, the evidence here is genuinely uncertain, and it is not known whether this translates into any real health effect for most people taking acebutolol. If you have questions or take this medication long term, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Acebutolol →

Acetazolamide

Insufficient Evidence

Brand names include Diamox, Ak-Zol

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Acetazolamide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also works as an antioxidant throughout the body. Some blood-pressure-lowering medications have been reported to interfere with the enzymes that make or use CoQ10, which could nudge levels down slightly, and acetazolamide falls into that broader drug category. That said, the evidence here is really thin, and it is genuinely not known whether any small drop in CoQ10 actually causes problems for people taking this medication. If you are curious or have concerns, it is worth bringing up with your pharmacist or doctor at your next visit.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Acetazolamide →

Aliskiren

Insufficient Evidence

Brand names include Tekturna

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Aliskiren? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Some antihypertensive medications appear to interfere with the enzymes that make or use coenzyme Q10 in the body, and aliskiren belongs to that broader drug class. That said, the evidence for aliskiren specifically is insufficient, meaning no one really knows yet whether this matters in practice. Most people taking aliskiren do not need to act on this, but if you are curious about your levels or whether a supplement makes sense for you, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Aliskiren →

Ambrisentan

Insufficient Evidence

Brand names include Letairis, Volibris

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Ambrisentan? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and the heart muscle relies on it quite a bit. Some antihypertensive medications have been reported to interfere with the enzymes that make coenzyme Q10 in the body, which could nudge levels down over time. That said, the evidence for ambrisentan specifically is insufficient, meaning researchers simply do not yet know whether this is a real concern for people taking it. If you are curious or have questions, your pharmacist or doctor is the right person to walk through it with you.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Ambrisentan →

Amiloride

Insufficient Evidence

Brand names include Midamor, Amilamont

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Amiloride? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and some research suggests that certain blood pressure medications may interfere with enzymes involved in making it. Amiloride is a diuretic rather than a beta blocker, so its specific effect on coenzyme Q10 is genuinely unclear, and the evidence here is rated insufficient. For most people taking amiloride, this is not something to lose sleep over, but if you are curious whether monitoring or any dietary changes make sense for you, a quick conversation with your pharmacist or doctor is the right move.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Amiloride →

Amiloride, Hydrochlorothiazide

Insufficient Evidence

Brand names include Moduretic, Amilzide, Moduret 25

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Amiloride, Hydrochlorothiazide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it may also play a role in heart health. Some blood pressure medications have been linked to mildly lower levels of it in the body, possibly by interfering with the enzymes that help make it. For this combination drug, though, the evidence is thin and the real-world significance is simply not known yet. If you are curious whether this applies to you, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Amiloride, Hydrochlorothiazide →

Amitriptyline

Insufficient Evidence

Brand names include Elavil

Tricyclic antidepressants can modestly decrease endogenous levels of coenzyme Q10.

Tricyclic antidepressants might inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to tricyclic antidepressant side effects.
Taking Amitriptyline? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Some research suggests that tricyclic antidepressants like amitriptyline may interfere with the enzymes involved in making coenzyme Q10, which could modestly reduce the body's natural levels. That said, the evidence here is really thin, and no one has shown this actually causes problems in people taking the medication. If you are curious about it, a quick conversation with your pharmacist or doctor is the right place to start.

References (1)
  1. Garrido-Maraver J, Cordero MD, Oropesa-Ávila M, et al. Coenzyme Q10 therapy. Mol Syndromol. 2014;5(3-4):187-97.

Full nutrient report for Amitriptyline →

Amitriptyline, Chlordiazepoxide

Insufficient Evidence

Brand names include Limbitrol DS

Tricyclic antidepressants can modestly decrease endogenous levels of coenzyme Q10.

Tricyclic antidepressants might inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to tricyclic antidepressant side effects.
Taking Amitriptyline, Chlordiazepoxide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is something your cells use to produce energy, and it plays a role in keeping your heart and muscles working well. The tricyclic antidepressant component of this medication (amitriptyline) may interfere with how the body makes or uses CoQ10 at the cellular level, possibly leading to modestly lower levels over time. That said, the evidence here is really thin, and right now we simply do not know if this has any meaningful effect on how you feel. If you are curious or have been on this medication long-term, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Garrido-Maraver J, Cordero MD, Oropesa-Ávila M, et al. Coenzyme Q10 therapy. Mol Syndromol. 2014;5(3-4):187-97.

Full nutrient report for Amitriptyline, Chlordiazepoxide →

Amitriptyline, Perphenazine

Insufficient Evidence

Brand names include Triavil, Etrafon, Etrafon-A

Tricyclic antidepressants can modestly decrease endogenous levels of coenzyme Q10.

Tricyclic antidepressants might inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to tricyclic antidepressant side effects.
Taking Amitriptyline, Perphenazine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Research suggests that tricyclic antidepressants like amitriptyline may interfere with the enzymes involved in making coenzyme Q10, which could modestly reduce the amount your body produces on its own. That said, the evidence here is really preliminary, and it is not currently known whether this reduction causes any real-world health effects or contributes to side effects. If you have questions or concerns, it is worth bringing up with your pharmacist or doctor.

References (1)
  1. Garrido-Maraver J, Cordero MD, Oropesa-Ávila M, et al. Coenzyme Q10 therapy. Mol Syndromol. 2014;5(3-4):187-97.

Full nutrient report for Amitriptyline, Perphenazine →

Amlodipine

Insufficient Evidence

Brand names include Norliqva

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Amlodipine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your body makes naturally that helps your cells produce energy and acts as an antioxidant. Some blood pressure medications have been reported to interfere with the enzymes that make or use CoQ10, which could modestly lower the amount your body has on hand. For amlodipine specifically, the evidence is quite limited and the clinical importance is simply not known yet. Most people taking amlodipine do not need to worry about this, but if you are curious about your CoQ10 status, it is worth bringing up with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Amlodipine →

Amlodipine Benzoate

Insufficient Evidence

Brand names include Katerzia

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Amlodipine Benzoate? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. A few blood pressure medications have been reported to interfere with CoQ10 enzyme activity, which could modestly reduce the body's own supply of it. For amlodipine specifically, the evidence is quite thin, and right now it simply is not known whether any reduction is large enough to matter clinically. If you have been on amlodipine long term and are curious about this, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Amlodipine Benzoate →

Amlodipine Besilate

Insufficient Evidence

Brand names include Istin

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Amlodipine Besilate? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and the heart muscle in particular depends on it. Some blood pressure medications have been linked to mildly lower levels of coenzyme Q10, possibly by interfering with the enzymes the body uses to make it, though how much this applies specifically to amlodipine is not well established. The evidence here is rated insufficient, meaning researchers simply do not have enough data yet to know whether this is a real concern for people taking amlodipine. Most people do not need to act on this, but if you are curious about your levels or considering a supplement, your pharmacist or doctor is a good place to start that conversation.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Amlodipine Besilate →

Amlodipine Besylate

Insufficient Evidence

Brand names include Norvasc

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Amlodipine Besylate? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a naturally made compound your cells use to produce energy, and your heart muscle in particular depends on it. Some blood pressure medications seem to interfere with the enzymes your body uses to make its own CoQ10, though it is worth noting that amlodipine works differently from the drugs most often linked to this effect, like beta blockers. Because the evidence here is truly insufficient, no one can say yet whether this matters in practice for amlodipine users. If you are curious or want peace of mind, it is worth bringing up with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Amlodipine Besylate →

Amlodipine Besylate, Benazepril

Insufficient Evidence

Brand names include Lotrel

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Amlodipine Besylate, Benazepril? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Some antihypertensive medications have been linked to modest reductions in the body's own CoQ10 levels, possibly by interfering with the enzymes involved in making it, though whether amlodipine and benazepril specifically do this is not well established. The current evidence is simply insufficient to know if this matters in a real, practical way for most people taking this combination. If you are curious about your CoQ10 status, it is worth bringing up with your pharmacist or doctor rather than acting on it on your own.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Amlodipine Besylate, Benazepril →

Amlodipine, Celecoxib

Insufficient Evidence

Brand names include Consensi

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Amlodipine, Celecoxib? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Some blood pressure medications have been reported to interfere with the enzymes that make CoQ10 naturally, which could modestly lower your body's own supply. That said, the evidence here is really preliminary, and there is no solid proof that amlodipine specifically causes a meaningful drop or that it leads to any noticeable symptoms. This is worth mentioning to your pharmacist or doctor if you are curious, but most people do not need to act on this right now.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Amlodipine, Celecoxib →

Ammonium Chloride

Insufficient Evidence
Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Ammonium Chloride? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to generate energy, and it also acts as an antioxidant. Ammonium chloride is not a typical antihypertensive, so the connection here is unclear, and right now there simply is not enough evidence to know whether it meaningfully affects coenzyme Q10 levels at all. Most people taking ammonium chloride do not need to worry about this. That said, if you have questions about your specific situation, your pharmacist or doctor is the right person to ask.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Ammonium Chloride →

Amoxapine

Insufficient Evidence

Brand names include Asendin

Tricyclic antidepressants can modestly decrease endogenous levels of coenzyme Q10.

Tricyclic antidepressants might inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to tricyclic antidepressant side effects.
Taking Amoxapine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and some research suggests tricyclic antidepressants like amoxapine may interfere with its activity in the body. The thinking is that these medications might slow down certain enzyme steps involved in making or using CoQ10, leading to a modest dip in levels. That said, the evidence here is really thin, and nobody has shown this translates into any real problem for patients. If you are curious whether this is worth paying attention to in your situation, it is a good question to bring up with your pharmacist or doctor.

References (1)
  1. Garrido-Maraver J, Cordero MD, Oropesa-Ávila M, et al. Coenzyme Q10 therapy. Mol Syndromol. 2014;5(3-4):187-97.

Full nutrient report for Amoxapine →

Aprocitentan

Insufficient Evidence

Brand names include Tryvio

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Aprocitentan? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your body makes that helps your cells produce energy and acts as an antioxidant. Some blood pressure medications have been reported to interfere with the enzymes that make coenzyme Q10, which could nudge levels down slightly, and aprocitentan belongs to that broader drug family. That said, the evidence for aprocitentan specifically is thin, and no one has shown this translates into real health problems. If you are curious whether monitoring or supplementing makes sense for you, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Aprocitentan →

Atenolol

Insufficient Evidence

Brand names include Tenormin, Atenix

Beta-blockers can decrease endogenous levels of coenzyme Q10.

Beta-blockers are thought to inhibit coenzyme Q10 mitochondrial enzymes and decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to beta-blocker side effects.
Taking Atenolol? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it plays a role in keeping the heart muscle working efficiently. Atenolol belongs to a class of medications called beta-blockers, which some research suggests may interfere with the mitochondrial enzymes your body needs to make coenzyme Q10, potentially nudging levels a little lower. That said, the evidence here is really thin, and it is not known whether this dip actually causes any harm or contributes to side effects. If you are curious whether this applies to you, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi H, Kishi T, Folkers K. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q10 enzymes by clinically used anti-hypertensive drugs. Res Commun Chem Pathol Pharmacol 1975;12:533-40.

Full nutrient report for Atenolol →

Atenolol, Chlortalidone

Insufficient Evidence

Brand names include AtenixCo, Totaretic, Tenoret 50

Beta-blockers can decrease endogenous levels of coenzyme Q10.

Beta-blockers are thought to inhibit coenzyme Q10 mitochondrial enzymes and decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to beta-blocker side effects.
Taking Atenolol, Chlortalidone? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. There is some early research suggesting that beta blockers like atenolol may interfere with the enzymes your body uses to make coenzyme Q10, which could nudge its natural levels down a bit. That said, the evidence here is really thin, and it is not known whether this small change actually matters for your health. If you are curious about it, a conversation with your pharmacist or doctor is the right starting point.

References (1)
  1. Kishi H, Kishi T, Folkers K. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q10 enzymes by clinically used anti-hypertensive drugs. Res Commun Chem Pathol Pharmacol 1975;12:533-40.

Full nutrient report for Atenolol, Chlortalidone →

Atenolol, Chlorthalidone

Insufficient Evidence

Brand names include Tenoretic

Beta-blockers can decrease endogenous levels of coenzyme Q10.

Beta-blockers are thought to inhibit coenzyme Q10 mitochondrial enzymes and decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to beta-blocker side effects.
Taking Atenolol, Chlorthalidone? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it plays a role in keeping the heart and muscles working well. Atenolol, as a beta-blocker, may interfere with certain enzymes inside your cells' mitochondria that are involved in making CoQ10, which could nudge levels a bit lower. That said, the evidence here is really thin, and researchers have not confirmed this matters in any practical way for most people taking it. If you are curious or have concerns, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi H, Kishi T, Folkers K. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q10 enzymes by clinically used anti-hypertensive drugs. Res Commun Chem Pathol Pharmacol 1975;12:533-40.

Full nutrient report for Atenolol, Chlorthalidone →

Atorvastatin

Insufficient Evidence

Brand names include Atorvaliq

Statins can halt the synthesis of coenzyme Q10, reducing endogenous levels. However, it is not clear whether this contributes to statin adverse effects, or if coenzyme Q10 supplements reduce these adverse effects.

HMG-CoA reductase inhibitors can reduce serum coenzyme Q10 levels. They block the synthesis of mevalonic acid, which is a precursor of coenzyme Q10, in a dose-dependent manner. Taking atorvastatin 80 mg daily for 30 days reduces coenzyme Q10 serum levels by 52%, but atorvastatin 10 mg daily or pravastatin 20 mg daily do not have this effect in healthy people. In other research, taking simvastatin 20 mg daily for 4 weeks reduces serum coenzyme Q10 levels by about 32%, but muscle levels increase by 47%. Since coenzyme Q10 is transported with low-density lipoprotein (LDL) cholesterol, reduction in LDL cholesterol levels by a statin may increase the amount of free coenzyme Q10 in the blood that is available for uptake into muscles. There is no reliable evidence that statin adverse effects such as myopathy are linked to reduced coenzyme Q10 levels in the blood, or that taking coenzyme Q10 supplements reduces statin side effects.
Taking Atorvastatin? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it happens to be made through the same biological pathway that atorvastatin blocks to lower cholesterol. Because of that overlap, higher doses of atorvastatin have been shown to reduce coenzyme Q10 levels in the blood, though interestingly, muscle levels may not drop in the same way. Right now there is not enough reliable evidence to know whether this blood-level change actually causes any harm, so most people do not need to act on this. If you are curious or have questions about muscle symptoms, it is worth bringing up with your pharmacist or doctor.

References (12)
  1. Folkers K, Langsjoen P, Willis R, et al. Lovastatin decreases coenzyme Q levels in humans. Proc Natl Acad Sci USA 1990;87:8931-4. PubMed
  2. Mortensen SA, Leth A, Agner E, et al. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med 1997;18:S137-44. PubMed
  3. Ghirlanda G, Oradei A, Manto A, et al. Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: A double blind, placebo-controlled study. J Clin Pharmacol 1993;33:226-9. PubMed
  4. De Pinieux G, Chariot P, Ammi-Said M, et al. Lipid-lowering drugs and mitochondrial function: Effects of HMG-CoA Reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Br J Clin Pharmacol 1996;42:333-7. PubMed
  5. Bargossi AM, Grossi G, Fiorella PL, et al. Exogenous CoQ10 supplementation prevents plasma ubiquinone reduction induced by HMG-CoA reductase inhibitors. Mol Aspects Med 1994;15:187-93. PubMed
  6. Watts GF, Castelluccio C, Rice-Evans C, et al. Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin. J Clin Pathol 1993;46:1055-7.
  7. Hanaki Y, Sugiyama S, Ozawa T, et al. Coenzyme Q10 and coronary artery disease. Clin Investig 1993;71:112-5. PubMed
  8. Berthold HK, Naini A, Di Mauro S, et al. Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial. Drug Saf 2006;29:703-12. PubMed
  9. Fuke C, Krikorian SA, Couris RR. Coenzyme Q10: A review of essential functions and clinical trials. US Pharm 2000;25:28-41.
  10. Bleske BE, Willis RA, Anthony M, et al. The effect of pravastatin and atorvastatin on coenzyme Q10. Am Heart J 2001;142:E2. PubMed
  11. Rundek T, Naini A, Sacco R, et al. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. Arch Neurol 2004;61:889-92.. PubMed
  12. Laaksonen R, Jokelainen K, Sahi T, et al. Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans. Clin Pharmacol Ther 1995;57:62-6. PubMed

Full nutrient report for Atorvastatin →

Atorvastatin Calcium

Insufficient Evidence

Brand names include Lipitor

Statins can halt the synthesis of coenzyme Q10, reducing endogenous levels. However, it is not clear whether this contributes to statin adverse effects, or if coenzyme Q10 supplements reduce these adverse effects.

HMG-CoA reductase inhibitors can reduce serum coenzyme Q10 levels. They block the synthesis of mevalonic acid, which is a precursor of coenzyme Q10, in a dose-dependent manner. Taking atorvastatin 80 mg daily for 30 days reduces coenzyme Q10 serum levels by 52%, but atorvastatin 10 mg daily or pravastatin 20 mg daily do not have this effect in healthy people. In other research, taking simvastatin 20 mg daily for 4 weeks reduces serum coenzyme Q10 levels by about 32%, but muscle levels increase by 47%. Since coenzyme Q10 is transported with low-density lipoprotein (LDL) cholesterol, reduction in LDL cholesterol levels by a statin may increase the amount of free coenzyme Q10 in the blood that is available for uptake into muscles. There is no reliable evidence that statin adverse effects such as myopathy are linked to reduced coenzyme Q10 levels in the blood, or that taking coenzyme Q10 supplements reduces statin side effects.
Taking Atorvastatin Calcium? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and atorvastatin can reduce the body's ability to make it. Here is why: atorvastatin blocks a liver pathway called HMG-CoA reductase, and that same pathway is needed to build coenzyme Q10, not just cholesterol. Higher doses appear more likely to affect levels than lower ones. That said, the evidence is genuinely unclear right now, so if you have questions about whether this matters for you personally, it is worth a quick conversation with your pharmacist or doctor.

References (12)
  1. Folkers K, Langsjoen P, Willis R, et al. Lovastatin decreases coenzyme Q levels in humans. Proc Natl Acad Sci USA 1990;87:8931-4. PubMed
  2. Mortensen SA, Leth A, Agner E, et al. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med 1997;18:S137-44. PubMed
  3. Ghirlanda G, Oradei A, Manto A, et al. Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: A double blind, placebo-controlled study. J Clin Pharmacol 1993;33:226-9. PubMed
  4. De Pinieux G, Chariot P, Ammi-Said M, et al. Lipid-lowering drugs and mitochondrial function: Effects of HMG-CoA Reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Br J Clin Pharmacol 1996;42:333-7. PubMed
  5. Bargossi AM, Grossi G, Fiorella PL, et al. Exogenous CoQ10 supplementation prevents plasma ubiquinone reduction induced by HMG-CoA reductase inhibitors. Mol Aspects Med 1994;15:187-93. PubMed
  6. Watts GF, Castelluccio C, Rice-Evans C, et al. Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin. J Clin Pathol 1993;46:1055-7.
  7. Hanaki Y, Sugiyama S, Ozawa T, et al. Coenzyme Q10 and coronary artery disease. Clin Investig 1993;71:112-5. PubMed
  8. Berthold HK, Naini A, Di Mauro S, et al. Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial. Drug Saf 2006;29:703-12. PubMed
  9. Fuke C, Krikorian SA, Couris RR. Coenzyme Q10: A review of essential functions and clinical trials. US Pharm 2000;25:28-41.
  10. Bleske BE, Willis RA, Anthony M, et al. The effect of pravastatin and atorvastatin on coenzyme Q10. Am Heart J 2001;142:E2. PubMed
  11. Rundek T, Naini A, Sacco R, et al. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. Arch Neurol 2004;61:889-92.. PubMed
  12. Laaksonen R, Jokelainen K, Sahi T, et al. Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans. Clin Pharmacol Ther 1995;57:62-6. PubMed

Full nutrient report for Atorvastatin Calcium →

Azilsartan

Insufficient Evidence

Brand names include Edarbi

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Azilsartan? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and your heart muscle in particular depends on it. Some blood pressure medications have been reported to interfere with certain enzymes the body uses to make or activate CoQ10, which could nudge levels down a bit. For azilsartan specifically, the evidence is thin and we honestly do not know whether any small change in CoQ10 levels matters in a real-world sense. If you are curious or have concerns, it is worth raising with your pharmacist or doctor rather than making any changes on your own.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Azilsartan →

Azilsartan, Chlorthalidone

Insufficient Evidence

Brand names include Edarbyclor

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Azilsartan, Chlorthalidone? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Some blood pressure medications have been linked to modest reductions in the body's own CoQ10 levels, possibly by interfering with the enzymes that make or use it, though exactly how this applies to azilsartan and chlorthalidone specifically is not well established. The evidence here is rated as insufficient, meaning researchers simply do not have enough data yet to know whether this matters in practice. For now, most people taking this combination do not need to act on this, but if you are curious about your CoQ10 status, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Azilsartan, Chlorthalidone →

Benazepril

Insufficient Evidence

Brand names include Lotensin

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Benazepril? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your body makes that helps cells produce energy and acts as an antioxidant. Some blood pressure medications have been reported to interfere with the enzymes that make or use coenzyme Q10, and benazepril falls into that broader category, though the exact mechanism for this specific drug is not well established. The evidence here is simply too limited to know whether this matters in any real, practical way for most people taking benazepril. If you have concerns, it is worth bringing up with your pharmacist or doctor rather than starting a supplement on your own.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Benazepril →

Benazepril, Hydrochlorothiazide

Insufficient Evidence

Brand names include Lotensin HCT

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Benazepril, Hydrochlorothiazide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. Some antihypertensive medications have been associated with mildly lower CoQ10 levels, possibly by interfering with the enzymes your body uses to make it naturally. That said, the evidence for this combination is genuinely thin, and it is not known whether any reduction is meaningful in practice. Most people taking this medication do not need to act on this, but if you are curious about your CoQ10 status, it is worth a quick chat with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Benazepril, Hydrochlorothiazide →

Bendroflumethiazide

Insufficient Evidence

Brand names include Naturetin, Aprinox, Neo-NaClex

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Bendroflumethiazide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Some blood pressure medications, including thiazide-type drugs like bendroflumethiazide, have been reported to interfere with the enzymes that help your body make or use coenzyme Q10, which could modestly affect its levels. That said, the evidence here is really thin, and no one has clearly shown this causes any practical harm. If you are curious about your levels or whether a supplement makes sense for you, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Bendroflumethiazide →

Bendroflumethiazide, Nadolol

Insufficient Evidence

Brand names include Corzide

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Bendroflumethiazide, Nadolol? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a substance your body makes naturally that helps cells generate energy, and the heart muscle relies on it quite a bit. Nadolol belongs to a class called beta blockers, and some research suggests beta blockers may partially interfere with the enzymes your body uses to produce coenzyme Q10, which could nudge levels down a little. That said, the evidence here is rated insufficient, meaning researchers simply do not yet know whether this dip is meaningful in practice. If you are curious or have concerns, it is worth bringing up with your pharmacist or doctor rather than starting anything on your own.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Bendroflumethiazide, Nadolol →

Brand names include Rauzide

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Bendroflumethiazide, Rauwolfia Serpentina? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and the heart muscle in particular depends on healthy levels of it. Some blood pressure medications appear to interfere with the enzymes that make or use coenzyme Q10 in the body, and this combination may fall into that category. That said, the evidence here is truly thin, with no clear proof that any meaningful drop actually occurs or causes problems. Most people taking this medication do not need to act on this, but if you are curious about your levels or whether a supplement makes sense for you, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Bendroflumethiazide, Rauwolfia Serpentina →

Benzthiazide

Insufficient Evidence

Brand names include Exna

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Benzthiazide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Some antihypertensive medications, possibly including benzthiazide, have been linked to mildly lower levels of it, perhaps by interfering with the enzymes your body uses to make it naturally. That said, the evidence here is really thin, and right now nobody knows whether this small change actually matters for your health. If you have questions or are thinking about a supplement, it is worth a quick conversation with your pharmacist or doctor first.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Benzthiazide →

Betaxolol

Insufficient Evidence

Brand names include Kerlone, Betoptic

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Betaxolol? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Beta blockers like betaxolol are thought to interfere with certain enzymes involved in making or using CoQ10, which could modestly lower your body's natural levels. That said, the evidence here is really thin, and it is not clear this drop matters in any practical way for most people. If you are curious whether this is worth paying attention to in your situation, it is a good question to bring up with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Betaxolol →

Bisoprolol

Insufficient Evidence

Brand names include Zebeta

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Bisoprolol? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Beta blockers like bisoprolol may interfere with certain enzymes involved in making CoQ10, which could nudge levels slightly lower over time. That said, the evidence here is genuinely thin, and researchers have not confirmed this matters clinically for most people. If you have been on bisoprolol long-term and are curious, it is worth a conversation with your pharmacist or doctor before considering any supplement.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Bisoprolol →

Bisoprolol, Hydrochlorothiazide

Insufficient Evidence

Brand names include Ziac

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Bisoprolol, Hydrochlorothiazide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Beta blockers like bisoprolol appear to interfere with the enzymes your body uses to make coenzyme Q10, which could modestly reduce your natural levels over time. That said, the current evidence is really insufficient to know whether this matters clinically, and there is no solid proof it causes any noticeable side effects. If you are curious or have been taking this medication long term, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Bisoprolol, Hydrochlorothiazide →

Bosentan

Insufficient Evidence

Brand names include Tracleer

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Bosentan? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it may also play a role in heart and muscle function. Some antihypertensive medications are thought to interfere with the enzymes your body uses to make CoQ10, which could nudge levels a little lower over time. For bosentan specifically, the evidence is genuinely thin, so right now this is more of an open question than a proven concern. If you are curious whether this applies to you, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Bosentan →

Bumetanide

Insufficient Evidence

Brand names include Burinex

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Bumetanide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. Some antihypertensive medications have been associated with mildly reduced CoQ10 levels, possibly by interfering with the enzymes the body uses to make it. That said, bumetanide is a loop diuretic, not one of the drug types where this has been clearly shown, and the overall evidence here is simply insufficient to know whether this matters in practice. Most people taking bumetanide do not need to act on this, but if you are curious, your pharmacist or doctor can help you think it through.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Bumetanide →

Bumetanide (IV)

Insufficient Evidence

Brand names include Bumex

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Bumetanide (IV)? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. A few antihypertensive medications have been linked to slightly lower levels of it, possibly by interfering with the enzymes your body uses to make it. Whether bumetanide specifically does this is genuinely unclear, and right now the evidence is too thin to know if it matters at all. Most people on this medication do not need to take any action, but if you are curious, your pharmacist or doctor can talk it through with you.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Bumetanide (IV) →

Bumetanide (Oral)

Insufficient Evidence

Brand names include Bumex

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Bumetanide (Oral)? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and the heart muscle in particular depends on it. Bumetanide is a diuretic rather than one of the antihypertensive drug classes most closely linked to this issue, but some blood pressure medications as a group have been reported to interfere with CoQ10 enzyme activity, possibly nudging levels down. The honest answer here is that researchers simply do not have enough solid evidence yet to know whether this matters in practice for bumetanide users. For now, there is nothing you need to act on, but if you are curious about your CoQ10 status, your pharmacist or doctor is a good place to start that conversation.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Bumetanide (Oral) →

Candesartan Cilexetil

Insufficient Evidence

Brand names include Atacand, Amias

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Candesartan Cilexetil? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and the heart muscle relies on it heavily. Some blood pressure medications have been linked to mildly reduced CoQ10 activity in the body, possibly by interfering with the enzymes involved in making it, though whether candesartan specifically does this is not well established. Right now the evidence for this interaction is too thin to draw firm conclusions, so most people taking candesartan do not need to act on this. If you are curious or have concerns, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Candesartan Cilexetil →

Brand names include Atacand HCT

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Candesartan Cilexetil, Hydrochlorothiazide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and the heart muscle in particular depends on it. Some blood pressure medications have been linked to modest reductions in the body's own CoQ10 levels, possibly by interfering with the enzymes that make or activate it, though exactly how this combination fits into that picture is not well understood. Right now the evidence is simply too limited to know whether this matters in any real, practical way for most people. If you are curious, it is worth bringing up with your pharmacist or doctor, especially if you take this medication long-term.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Candesartan Cilexetil, Hydrochlorothiazide →

Captopril

Insufficient Evidence

Brand names include Capoten, Acepril

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Captopril? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Some blood pressure medications appear to interfere with the enzymes that make or use CoQ10, which could nudge levels down a little, though whether captopril specifically does this is not well established. The evidence here is genuinely thin, so this is not something most people on captopril need to worry about right now. Still, if you have questions or take captopril long-term, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Captopril →

Captopril, Hydrochlorothiazide

Insufficient Evidence

Brand names include Capozide, Acezide

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Captopril, Hydrochlorothiazide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is something your body makes on its own, and your cells use it to produce energy and protect themselves from damage. A few antihypertensive medications have been linked to slightly lower CoQ10 levels, possibly by interfering with the enzymes your body needs to make it. For captopril and hydrochlorothiazide specifically, the evidence is quite thin, and right now there is no clear proof this causes any real health problem. If you are curious whether you need to pay attention to this, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Captopril, Hydrochlorothiazide →

Carteolol

Insufficient Evidence

Brand names include Cartrol, Ocupress

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Carteolol? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and the heart muscle in particular depends on it. Carteolol is a beta blocker, and some research suggests that beta blockers may interfere with the enzymes that help your body make coenzyme Q10 naturally, which could modestly reduce your levels over time. That said, the evidence here is rated insufficient, meaning we really do not have enough solid data to know whether this actually causes a problem in practice. If you have been taking carteolol long-term and are curious, it is worth bringing up with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Carteolol →

Carvedilol

Insufficient Evidence

Brand names include Coreg, Coreg CR

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Carvedilol? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Carvedilol is a beta blocker, and there is some research suggesting that beta blockers may interfere with the enzymes your body needs to make coenzyme Q10 on its own, potentially nudging levels a little lower. That said, the evidence here is genuinely uncertain, and it is not known whether this translates into any real-world problem for people taking carvedilol. If you are curious whether this is worth monitoring for you personally, it is a great question to bring up with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Carvedilol →

Celiprolol

Insufficient Evidence

Brand names include Celicard

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Celiprolol? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your body makes that helps cells produce energy, and the heart muscle relies on it quite a bit. Celiprolol is a beta blocker, and some beta blockers appear to interfere with the enzymes your body uses to produce coenzyme Q10, which could modestly reduce your levels over time. That said, the evidence here is genuinely unclear, and there is no solid proof this matters in practice for most people. If you have been on celiprolol long-term and are curious, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Celiprolol →

Cerivastatin Sodium

Insufficient Evidence

Brand names include Baycol

Statins can halt the synthesis of coenzyme Q10, reducing endogenous levels. However, it is not clear whether this contributes to statin adverse effects, or if coenzyme Q10 supplements reduce these adverse effects.

HMG-CoA reductase inhibitors can reduce serum coenzyme Q10 levels. They block the synthesis of mevalonic acid, which is a precursor of coenzyme Q10, in a dose-dependent manner. Taking atorvastatin 80 mg daily for 30 days reduces coenzyme Q10 serum levels by 52%, but atorvastatin 10 mg daily or pravastatin 20 mg daily do not have this effect in healthy people. In other research, taking simvastatin 20 mg daily for 4 weeks reduces serum coenzyme Q10 levels by about 32%, but muscle levels increase by 47%. Since coenzyme Q10 is transported with low-density lipoprotein (LDL) cholesterol, reduction in LDL cholesterol levels by a statin may increase the amount of free coenzyme Q10 in the blood that is available for uptake into muscles. There is no reliable evidence that statin adverse effects such as myopathy are linked to reduced coenzyme Q10 levels in the blood, or that taking coenzyme Q10 supplements reduces statin side effects.
Taking Cerivastatin Sodium? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is something your cells use to produce energy, and it shows up in the heart and muscles especially. Cerivastatin, like other statins, works by blocking a liver pathway called HMG-CoA reductase, and that same pathway happens to be a stepping stone in the body's own production of coenzyme Q10, so blood levels can dip. That said, the evidence here is genuinely uncertain: researchers are still unsure whether lower blood levels actually cause problems in practice, or whether taking a supplement helps. If you have questions or notice muscle discomfort while on this medication, it is worth bringing up with your pharmacist or doctor.

References (12)
  1. Folkers K, Langsjoen P, Willis R, et al. Lovastatin decreases coenzyme Q levels in humans. Proc Natl Acad Sci USA 1990;87:8931-4. PubMed
  2. Mortensen SA, Leth A, Agner E, et al. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med 1997;18:S137-44. PubMed
  3. Ghirlanda G, Oradei A, Manto A, et al. Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: A double blind, placebo-controlled study. J Clin Pharmacol 1993;33:226-9. PubMed
  4. De Pinieux G, Chariot P, Ammi-Said M, et al. Lipid-lowering drugs and mitochondrial function: Effects of HMG-CoA Reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Br J Clin Pharmacol 1996;42:333-7. PubMed
  5. Bargossi AM, Grossi G, Fiorella PL, et al. Exogenous CoQ10 supplementation prevents plasma ubiquinone reduction induced by HMG-CoA reductase inhibitors. Mol Aspects Med 1994;15:187-93. PubMed
  6. Watts GF, Castelluccio C, Rice-Evans C, et al. Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin. J Clin Pathol 1993;46:1055-7.
  7. Hanaki Y, Sugiyama S, Ozawa T, et al. Coenzyme Q10 and coronary artery disease. Clin Investig 1993;71:112-5. PubMed
  8. Berthold HK, Naini A, Di Mauro S, et al. Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial. Drug Saf 2006;29:703-12. PubMed
  9. Fuke C, Krikorian SA, Couris RR. Coenzyme Q10: A review of essential functions and clinical trials. US Pharm 2000;25:28-41.
  10. Bleske BE, Willis RA, Anthony M, et al. The effect of pravastatin and atorvastatin on coenzyme Q10. Am Heart J 2001;142:E2. PubMed
  11. Rundek T, Naini A, Sacco R, et al. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. Arch Neurol 2004;61:889-92.. PubMed
  12. Laaksonen R, Jokelainen K, Sahi T, et al. Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans. Clin Pharmacol Ther 1995;57:62-6. PubMed

Full nutrient report for Cerivastatin Sodium →

Chlorothiazide

Insufficient Evidence

Brand names include Diuril

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Chlorothiazide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. Some antihypertensive medications, possibly including chlorothiazide, have been linked to modest reductions in the body's own CoQ10 levels, perhaps by interfering with enzymes involved in making or using it. That said, the evidence here is genuinely insufficient, meaning researchers simply do not yet know whether this matters in practice. No action is needed based on current evidence, but feel free to bring it up with your pharmacist or doctor if you are curious.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Chlorothiazide →

Chlorothiazide, Methyldopa

Insufficient Evidence

Brand names include Aldoclor 150, Aldochlor, Aldoclor 250

Thiazides can modestly decrease endogenous levels of coenzyme Q10.

Thiazide diuretics might decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to thiazide c side effects.
Taking Chlorothiazide, Methyldopa? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Some antihypertensive medications appear to interfere with certain enzymes involved in the body's own CoQ10 production, which could nudge levels slightly lower. That said, the evidence here is really thin, and it is not known whether any small drop actually causes problems. If you are curious whether this is worth watching in your case, it is a good question to bring up with your pharmacist or doctor.

References (1)
  1. LaValle JB. Hidden disruptions in metabolic syndrome: drug-induced nutrient depletion as a pathway to accelerated pathophysiology of metabolic syndrome. Altern Ther Health Med. 2006 Mar-Apr;12(2):26-31; quiz 32-3.

Full nutrient report for Chlorothiazide, Methyldopa →

Chlorothiazide, Reserpine

Insufficient Evidence

Brand names include Diupres

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Chlorothiazide, Reserpine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your body makes that helps cells produce energy and acts as an antioxidant. Some antihypertensive medications, possibly including this combination, have been linked to slightly lower CoQ10 levels, likely because they may interfere with the enzymes your body uses to produce it. That said, the evidence here is really thin, and no one has clearly shown this causes any real harm or symptoms. If you have concerns, it is worth a quick chat with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Chlorothiazide, Reserpine →

Chlorthalidone

Insufficient Evidence

Brand names include Hygroton, Thalitone

Thiazides can modestly decrease endogenous levels of coenzyme Q10.

Thiazide diuretics might decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to thiazide c side effects.
Taking Chlorthalidone? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and some early research suggests thiazide-type diuretics like chlorthalidone may modestly reduce the body's own levels of it. The honest answer right now is that nobody knows whether that small reduction actually matters in practice, and there is no good evidence linking it to any of chlorthalidone's known side effects. For most people taking this medication, this is not something that requires action. Still, if you are curious whether a coenzyme Q10 supplement makes sense for you, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. LaValle JB. Hidden disruptions in metabolic syndrome: drug-induced nutrient depletion as a pathway to accelerated pathophysiology of metabolic syndrome. Altern Ther Health Med. 2006 Mar-Apr;12(2):26-31; quiz 32-3.

Full nutrient report for Chlorthalidone →

Chlorthalidone, Clonidine

Insufficient Evidence

Brand names include Clorpres, Combipres

Thiazides can modestly decrease endogenous levels of coenzyme Q10.

Thiazide diuretics might decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to thiazide c side effects.
Taking Chlorthalidone, Clonidine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it may also play a role in heart health. Some research suggests that thiazide-type diuretics like chlorthalidone can modestly reduce the body's own coenzyme Q10 levels, possibly by interfering with how the body makes or maintains it. That said, the evidence here is really preliminary, and it is not known whether this small change actually causes any health problems in practice. If you are curious, it is worth a quick conversation with your pharmacist or doctor before considering any supplement.

References (1)
  1. LaValle JB. Hidden disruptions in metabolic syndrome: drug-induced nutrient depletion as a pathway to accelerated pathophysiology of metabolic syndrome. Altern Ther Health Med. 2006 Mar-Apr;12(2):26-31; quiz 32-3.

Full nutrient report for Chlorthalidone, Clonidine →

Cilazapril

Insufficient Evidence

Brand names include Inhibace

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Cilazapril? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. Some blood pressure medications have been linked to modest reductions in the body's own CoQ10 levels, possibly by interfering with the enzymes that make or use it, though exactly how cilazapril fits into this picture is not well established. Honestly, the evidence here is thin, and right now there is no solid proof this matters clinically for people taking cilazapril. If you are curious or have concerns, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Cilazapril →

Clevidipine

Insufficient Evidence

Brand names include Cleviprex

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Clevidipine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Some blood pressure medications have been linked to mildly lower levels of it, possibly by interfering with the enzymes your body uses to make it. For clevidipine specifically, the evidence is thin enough that researchers haven't been able to say whether this matters at all in practice. If you have concerns, it's worth bringing up with your pharmacist or doctor, but there is no clear reason for most people on this medication to worry right now.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Clevidipine →

Clomipramine

Insufficient Evidence

Brand names include Anafranil, Anafranil SR

Tricyclic antidepressants can modestly decrease endogenous levels of coenzyme Q10.

Tricyclic antidepressants might inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to tricyclic antidepressant side effects.
Taking Clomipramine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Some research suggests that tricyclic antidepressants like clomipramine may interfere with the enzymes involved in making or using CoQ10, which could modestly reduce the body's own levels. That said, the evidence here is really preliminary, and nobody has shown this causes any real health problem in people taking the medication. If you're curious whether this is worth discussing for your situation, a quick conversation with your pharmacist or doctor is the right place to start.

References (1)
  1. Garrido-Maraver J, Cordero MD, Oropesa-Ávila M, et al. Coenzyme Q10 therapy. Mol Syndromol. 2014;5(3-4):187-97.

Full nutrient report for Clomipramine →

Clonidine

Insufficient Evidence

Brand names include Catapres

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Clonidine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Some antihypertensive medications appear to interfere with the enzymes that make or use coenzyme Q10 in the body, which could nudge levels down a bit. For clonidine specifically, the evidence is quite thin, and right now there is simply not enough research to know whether any change in coenzyme Q10 levels is meaningful for people taking it. Most people on clonidine do not need to act on this, but if you are curious or have concerns, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Clonidine →

Cryptenamine, Methyclothiazide

Insufficient Evidence

Brand names include Diutensen

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Cryptenamine, Methyclothiazide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also works as an antioxidant throughout the body. Some antihypertensive medications, possibly including the drugs in this combination, have been reported to interfere with CoQ10 enzyme activity, which could nudge levels downward. That said, the evidence here is rated insufficient, meaning researchers simply do not yet know whether this matters in a real, noticeable way for patients. There is no need to worry or act on this right now, but if you have questions it is always fine to bring them up with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Cryptenamine, Methyclothiazide →

Cyclothiazide

Insufficient Evidence

Brand names include Fluidil, Anhydron

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Cyclothiazide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Cyclothiazide belongs to the thiazide diuretic family, and some research suggests these medications may modestly reduce the body's own CoQ10 levels, possibly because they interfere with the same biological pathway the body uses to make it. That said, the evidence here is still quite thin, and it is not known whether any drop in CoQ10 levels actually causes real-world problems. If you have concerns, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Cyclothiazide →

Daunorubicin Citrate

Insufficient Evidence

Brand names include DaunoXome

Anthracyclines might alter synthesis and storage of coenzyme Q10, but it is unclear whether coenzyme Q10 supplements are beneficial during anthracycline therapy.

Anthracycline chemotherapeutic agents are thought to inhibit coenzyme Q10 mitochondrial enzymes and the synthesis of coenzyme Q10 in the heart. However, plasma levels of coenzyme Q10 might actually rise immediately after treatment with these drugs, due to myocardial tissue damage resulting in release of coenzyme Q10 into plasma. Preliminary research suggests that coenzyme Q10 might protect against anthracycline cardiotoxicity, possibly through correction of coenzyme Q10 deficiencies and scavenging of free radicals. However, conflicting evidence exists. Additional research is needed before coenzyme Q10 supplementation can be routinely recommended during anthracycline therapy.
Taking Daunorubicin Citrate? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is something your heart cells rely on heavily to produce energy, and daunorubicin belongs to a drug class that may interfere with how the heart makes and stores it. The picture is actually a bit complicated here, because blood levels of coenzyme Q10 can temporarily rise after treatment, possibly because heart tissue releases it. Right now there simply is not enough reliable research to know whether this interaction matters clinically, so if you have questions about coenzyme Q10 during your treatment, that is a great conversation to have with your oncologist or pharmacist.

References (3)
  1. Eaton S, Skinner R, Hale JP, et al. Plasma coenzyme Q(10) in children and adolescents undergoing doxorubicin therapy. Clin Chim Acta 2000;302:1-9.
  2. Greenberg S, Frishman WH. Co-enzyme Q10: a new drug for cardiovascular disease. J Clin Pharmacol 1990;30:596-608.
  3. Tsubaki, K., Horiuchi, A., Kitani, T., Taniguchi, N., Masaoka, T., Shibata, H., Yonezawa, T., Tsubakio, T., Kawagoe, H., Shinohara, Y., and . [Investigation of the preventive effect of CoQ10 against the side- effects of anthracycline antineoplastic agent

Full nutrient report for Daunorubicin Citrate →

Daunorubicin, Cytarabine

Insufficient Evidence

Brand names include Vyxeos

Anthracyclines might alter synthesis and storage of coenzyme Q10, but it is unclear whether coenzyme Q10 supplements are beneficial during anthracycline therapy.

Anthracycline chemotherapeutic agents are thought to inhibit coenzyme Q10 mitochondrial enzymes and the synthesis of coenzyme Q10 in the heart. However, plasma levels of coenzyme Q10 might actually rise immediately after treatment with these drugs, due to myocardial tissue damage resulting in release of coenzyme Q10 into plasma. Preliminary research suggests that coenzyme Q10 might protect against anthracycline cardiotoxicity, possibly through correction of coenzyme Q10 deficiencies and scavenging of free radicals. However, conflicting evidence exists. Additional research is needed before coenzyme Q10 supplementation can be routinely recommended during anthracycline therapy.
Taking Daunorubicin, Cytarabine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your heart cells rely on to produce energy and protect themselves from damage. Daunorubicin is an anthracycline, a type of chemotherapy thought to interfere with how the heart makes and stores coenzyme Q10 inside its cells. That said, the evidence here is genuinely preliminary and conflicting, so no one yet knows whether this shift causes a real problem or whether taking a supplement would help. If you have questions, bring them up with your oncologist or pharmacist before doing anything on your own.

References (3)
  1. Eaton S, Skinner R, Hale JP, et al. Plasma coenzyme Q(10) in children and adolescents undergoing doxorubicin therapy. Clin Chim Acta 2000;302:1-9.
  2. Greenberg S, Frishman WH. Co-enzyme Q10: a new drug for cardiovascular disease. J Clin Pharmacol 1990;30:596-608.
  3. Tsubaki, K., Horiuchi, A., Kitani, T., Taniguchi, N., Masaoka, T., Shibata, H., Yonezawa, T., Tsubakio, T., Kawagoe, H., Shinohara, Y., and . [Investigation of the preventive effect of CoQ10 against the side- effects of anthracycline antineoplastic agent

Full nutrient report for Daunorubicin, Cytarabine →

Deserpidine

Insufficient Evidence

Brand names include Harmonyl

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Deserpidine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Some antihypertensive medications, possibly including deserpidine, have been reported to interfere with coenzyme Q10 enzyme activity, which could nudge levels downward. That said, the evidence here is truly insufficient, meaning researchers have not yet established whether this actually matters for people taking the drug. Most people do not need to act on this, but if you are curious about your levels, it is worth a conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Deserpidine →

Deserpidine, Hydrochlorothiazide

Insufficient Evidence

Brand names include Oreticyl Forte, Oreticyl

Thiazides can modestly decrease endogenous levels of coenzyme Q10.

Thiazide diuretics might decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to thiazide c side effects.
Taking Deserpidine, Hydrochlorothiazide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and the heart muscle in particular depends on it. Some antihypertensive medications appear to interfere with the enzymes that keep CoQ10 levels normal in the body, which could modestly lower how much is available. That said, the evidence here is really thin, so right now we simply do not know whether this combination causes a meaningful drop or causes any noticeable effects. If you are curious or have concerns, it is worth bringing up with your pharmacist or doctor.

References (1)
  1. LaValle JB. Hidden disruptions in metabolic syndrome: drug-induced nutrient depletion as a pathway to accelerated pathophysiology of metabolic syndrome. Altern Ther Health Med. 2006 Mar-Apr;12(2):26-31; quiz 32-3.

Full nutrient report for Deserpidine, Hydrochlorothiazide →

Deserpidine, Methyclothiazide

Insufficient Evidence

Brand names include Enduronyl Forte, Enduronyl

Thiazides can modestly decrease endogenous levels of coenzyme Q10.

Thiazide diuretics might decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to thiazide c side effects.
Taking Deserpidine, Methyclothiazide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and some research suggests the thiazide component in this combination (methyclothiazide) may modestly reduce the body's own levels of it, possibly by interfering with how the body makes or maintains it. That said, the evidence here is genuinely limited, and right now it is not known whether this small reduction causes any real health effects or contributes to side effects. Most people on this medication do not need to act on this, but if you are curious or have concerns, it is a good topic to bring up with your pharmacist or doctor.

References (1)
  1. LaValle JB. Hidden disruptions in metabolic syndrome: drug-induced nutrient depletion as a pathway to accelerated pathophysiology of metabolic syndrome. Altern Ther Health Med. 2006 Mar-Apr;12(2):26-31; quiz 32-3.

Full nutrient report for Deserpidine, Methyclothiazide →

Desipramine

Insufficient Evidence

Brand names include Norpramin, Pertofrane

Tricyclic antidepressants can modestly decrease endogenous levels of coenzyme Q10.

Tricyclic antidepressants might inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to tricyclic antidepressant side effects.
Taking Desipramine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Some research suggests that tricyclic antidepressants like desipramine may interfere with the enzymes involved in making coenzyme Q10, which could modestly reduce your body's own levels over time. That said, the evidence here is rated insufficient, meaning researchers simply do not yet have enough data to know whether this matters in practice for most people. If you have concerns, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Garrido-Maraver J, Cordero MD, Oropesa-Ávila M, et al. Coenzyme Q10 therapy. Mol Syndromol. 2014;5(3-4):187-97.

Full nutrient report for Desipramine →

Diltiazem

Insufficient Evidence

Brand names include Cardizem, Cardizem SR, Diltiaz SR

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Diltiazem? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your body makes that helps cells produce energy and acts as an antioxidant. Some antihypertensive medications have been reported to interfere with the enzymes that keep CoQ10 levels where they should be, and diltiazem falls into that broader category. That said, the evidence here is really thin, and nobody has clearly shown this actually causes a problem for people taking diltiazem. If you have concerns, it is worth a quick conversation with your pharmacist or doctor before doing anything differently.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Diltiazem →

Diltiazem, Enalapril

Insufficient Evidence

Brand names include Teczem

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Diltiazem, Enalapril? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and your heart muscle relies on it heavily. Some antihypertensive medications have been reported to interfere with the enzymes that help the body make its own CoQ10, which could modestly reduce levels over time. That said, the evidence for diltiazem and enalapril specifically is insufficient, meaning researchers simply do not yet know whether this matters in practice for most people. If you are curious or have concerns, it is worth bringing up with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Diltiazem, Enalapril →

Brand names include Cosopt PF

Beta-blockers can decrease endogenous levels of coenzyme Q10.

Beta-blockers are thought to inhibit coenzyme Q10 mitochondrial enzymes and decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to beta-blocker side effects.
Taking Dorzolamide Hydrochloride, Timolol Maleate? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Timolol, the beta-blocker in this eye drop combination, may interfere with certain enzymes inside your cells' mitochondria, which are the tiny structures that produce energy, and some research suggests this can nudge coenzyme Q10 levels down. Coenzyme Q10 is a compound your cells use to generate that energy and act as an antioxidant. That said, the evidence here is rated insufficient, meaning no one really knows if this drop is meaningful in practice. For most people using these drops, there is nothing urgent to act on, but your pharmacist or doctor is a good sounding board if you have questions.

References (1)
  1. Kishi H, Kishi T, Folkers K. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q10 enzymes by clinically used anti-hypertensive drugs. Res Commun Chem Pathol Pharmacol 1975;12:533-40.

Full nutrient report for Dorzolamide Hydrochloride, Timolol Maleate →

Dorzolamide, Timolol

Insufficient Evidence

Brand names include Cosopt

Beta-blockers can decrease endogenous levels of coenzyme Q10.

Beta-blockers are thought to inhibit coenzyme Q10 mitochondrial enzymes and decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to beta-blocker side effects.
Taking Dorzolamide, Timolol? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it plays a role in keeping the heart and muscles working properly. The timolol in this eye drop belongs to a drug class called beta-blockers, which some research suggests may interfere with the cellular machinery that makes coenzyme Q10, potentially nudging levels a bit lower over time. That said, the evidence here is genuinely thin, and it is not known whether any reduction is meaningful for most people using this medication. If you are curious or have concerns, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi H, Kishi T, Folkers K. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q10 enzymes by clinically used anti-hypertensive drugs. Res Commun Chem Pathol Pharmacol 1975;12:533-40.

Full nutrient report for Dorzolamide, Timolol →

Doxazosin Mesylate

Insufficient Evidence

Brand names include Cardura

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Doxazosin Mesylate? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and your heart muscle in particular depends on it. There is some research suggesting that certain blood pressure medications may interfere with the enzymes your body uses to make coenzyme Q10 on its own, though it is not firmly established whether doxazosin specifically works this way. Importantly, the evidence here is rated insufficient, meaning we simply do not have enough solid data to know if this matters in practice. If you are curious or have concerns, it is worth bringing up with your pharmacist or doctor rather than acting on it alone.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Doxazosin Mesylate →

Enalapril Maleate

Insufficient Evidence

Brand names include Vasotec, Epaned

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Enalapril Maleate? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is something your body makes on its own, and your cells use it to produce energy. Some antihypertensive medications have been linked to modest drops in CoQ10 levels, possibly by interfering with the enzymes your body needs to make it, though where enalapril fits in that picture is genuinely unclear. The evidence here is rated insufficient, meaning researchers simply do not have enough data yet to know if this matters in practice. Most people taking enalapril do not need to act on this, but if you have questions about CoQ10, your pharmacist or doctor is a good person to ask.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Enalapril Maleate →

Enalapril Maleate, Felodipine

Insufficient Evidence

Brand names include Lexxel

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Enalapril Maleate, Felodipine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your body makes that helps cells produce energy and acts as an antioxidant. Some antihypertensive medications have been reported to interfere with the enzymes that regulate coenzyme Q10 levels, which could modestly reduce how much your body has on hand. That said, the evidence for this with enalapril and felodipine is simply too limited to know whether it matters in real life, and there is no solid proof it causes side effects. If you are curious or have concerns, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Enalapril Maleate, Felodipine →

Brand names include Vaseretic

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Enalapril Maleate, Hydrochlorothiazide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and your heart muscle in particular depends on it. There is some research suggesting that certain blood pressure medications may interfere with the body's own ability to make CoQ10, though exactly how this combination fits into that picture is not well understood. The evidence here is rated as insufficient, meaning there simply is not enough solid data yet to know whether this is a real concern for patients taking this medication. For now, most people do not need to take action, but if you are curious or have symptoms like unusual fatigue, it is worth bringing up with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Enalapril Maleate, Hydrochlorothiazide →

Eplerenone

Insufficient Evidence

Brand names include Inspra

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Eplerenone? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and your heart muscle relies on it quite a bit. Some blood pressure medications have been reported to interfere with enzymes that help the body make its own CoQ10, and eplerenone belongs to that broader drug class, though whether this actually matters in real life is genuinely unknown right now. The evidence here is too thin to say this is a real concern, so most people on eplerenone do not need to act on this. That said, if you are curious or have other heart health questions, it is worth bringing up with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Eplerenone →

Epoprostenol

Insufficient Evidence

Brand names include Flolan

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Epoprostenol? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Some antihypertensive medications appear to interfere with enzymes that help the body make its own coenzyme Q10, and epoprostenol falls into that broader category. That said, the evidence here is really preliminary, and it is not clear this dip in levels means anything noticeable for most people. If you have questions or take epoprostenol long-term, it is worth bringing up with your pharmacist or doctor just to get their read on it.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Epoprostenol →

Eprosartan

Insufficient Evidence

Brand names include Teveten

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Eprosartan? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your body makes that helps cells produce energy and acts as an antioxidant. Some blood pressure medications have been shown to interfere with the enzymes that make or use CoQ10, and eprosartan belongs to the broader antihypertensive family where this has occasionally been noted. That said, the evidence here is really thin, and right now we simply do not know whether any small change in CoQ10 levels from eprosartan actually matters to your health. If you are curious or have concerns, it is worth a quick conversation with your pharmacist or doctor before considering anything.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Eprosartan →

Esmolol

Insufficient Evidence

Brand names include Brevibloc

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Esmolol? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a naturally made compound your cells use to produce energy, and it also acts as an antioxidant. Beta blockers like esmolol appear to interfere with the enzymes your body uses to make CoQ10, which can nudge those levels down a bit. That said, the evidence here is genuinely thin, and right now we do not know if this small drop causes any real health concern. If you have been on a beta blocker long term and are curious, it is worth bringing up with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Esmolol →

Ethacrynic Acid

Insufficient Evidence

Brand names include Edecrin

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Ethacrynic Acid? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and the heart muscle relies on it heavily. Ethacrynic acid is a diuretic rather than a traditional antihypertensive, but some blood-pressure-lowering drugs as a group have been reported to interfere with the enzymes that make or activate coenzyme Q10 in the body. Right now, the evidence for this with ethacrynic acid specifically is too thin to know whether it matters in practice, so most people do not need to act on this. If you are curious about your levels or whether a supplement makes sense for you, a quick conversation with your pharmacist or doctor is the right place to start.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Ethacrynic Acid →

Ezetimibe, Atorvastatin

Insufficient Evidence

Brand names include Liptruzet

Statins can halt the synthesis of coenzyme Q10, reducing endogenous levels. However, it is not clear whether this contributes to statin adverse effects, or if coenzyme Q10 supplements reduce these adverse effects.

HMG-CoA reductase inhibitors can reduce serum coenzyme Q10 levels. They block the synthesis of mevalonic acid, which is a precursor of coenzyme Q10, in a dose-dependent manner. Taking atorvastatin 80 mg daily for 30 days reduces coenzyme Q10 serum levels by 52%, but atorvastatin 10 mg daily or pravastatin 20 mg daily do not have this effect in healthy people. In other research, taking simvastatin 20 mg daily for 4 weeks reduces serum coenzyme Q10 levels by about 32%, but muscle levels increase by 47%. Since coenzyme Q10 is transported with low-density lipoprotein (LDL) cholesterol, reduction in LDL cholesterol levels by a statin may increase the amount of free coenzyme Q10 in the blood that is available for uptake into muscles. There is no reliable evidence that statin adverse effects such as myopathy are linked to reduced coenzyme Q10 levels in the blood, or that taking coenzyme Q10 supplements reduces statin side effects.
Taking Ezetimibe, Atorvastatin? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it happens to share part of the same production pathway that atorvastatin blocks. Because statins like atorvastatin interrupt that pathway to lower cholesterol, they can also reduce the body's own CoQ10 production, especially at higher doses. That said, the evidence here is rated insufficient, meaning researchers are genuinely unsure whether lower blood levels translate into real problems for most people. If you have questions about whether this applies to you, it is worth bringing up with your pharmacist or doctor.

References (12)
  1. Folkers K, Langsjoen P, Willis R, et al. Lovastatin decreases coenzyme Q levels in humans. Proc Natl Acad Sci USA 1990;87:8931-4. PubMed
  2. Mortensen SA, Leth A, Agner E, et al. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med 1997;18:S137-44. PubMed
  3. Ghirlanda G, Oradei A, Manto A, et al. Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: A double blind, placebo-controlled study. J Clin Pharmacol 1993;33:226-9. PubMed
  4. De Pinieux G, Chariot P, Ammi-Said M, et al. Lipid-lowering drugs and mitochondrial function: Effects of HMG-CoA Reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Br J Clin Pharmacol 1996;42:333-7. PubMed
  5. Bargossi AM, Grossi G, Fiorella PL, et al. Exogenous CoQ10 supplementation prevents plasma ubiquinone reduction induced by HMG-CoA reductase inhibitors. Mol Aspects Med 1994;15:187-93. PubMed
  6. Watts GF, Castelluccio C, Rice-Evans C, et al. Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin. J Clin Pathol 1993;46:1055-7.
  7. Hanaki Y, Sugiyama S, Ozawa T, et al. Coenzyme Q10 and coronary artery disease. Clin Investig 1993;71:112-5. PubMed
  8. Berthold HK, Naini A, Di Mauro S, et al. Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial. Drug Saf 2006;29:703-12. PubMed
  9. Fuke C, Krikorian SA, Couris RR. Coenzyme Q10: A review of essential functions and clinical trials. US Pharm 2000;25:28-41.
  10. Bleske BE, Willis RA, Anthony M, et al. The effect of pravastatin and atorvastatin on coenzyme Q10. Am Heart J 2001;142:E2. PubMed
  11. Rundek T, Naini A, Sacco R, et al. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. Arch Neurol 2004;61:889-92.. PubMed
  12. Laaksonen R, Jokelainen K, Sahi T, et al. Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans. Clin Pharmacol Ther 1995;57:62-6. PubMed

Full nutrient report for Ezetimibe, Atorvastatin →

Felodipine

Insufficient Evidence

Brand names include Plendil, Renedil

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Felodipine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your body makes naturally that helps cells produce energy and acts as an antioxidant. Some blood pressure medications have been linked to slightly lower CoQ10 levels, possibly by interfering with the enzymes your body uses to make it, though it is not fully clear whether felodipine specifically does this. Right now the evidence is too limited to know if this matters in any real way for people taking felodipine. If you are curious, it is worth a quick conversation with your pharmacist or doctor before considering any supplement.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Felodipine →

Fenoldopam

Insufficient Evidence

Brand names include Corlopam

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Fenoldopam? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and your heart muscle relies on it heavily. Some blood pressure medications appear to interfere with the enzymes that make coenzyme Q10 in the body, and fenoldopam falls into that general category of antihypertensives. That said, the evidence here is really thin, so this is more of an open question than a proven concern. If you use fenoldopam long-term, it is worth mentioning to your pharmacist or doctor, but there is currently no clear reason to worry.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Fenoldopam →

Fluvastatin

Insufficient Evidence

Brand names include Lescol, Lescol XL

Statins can halt the synthesis of coenzyme Q10, reducing endogenous levels. However, it is not clear whether this contributes to statin adverse effects, or if coenzyme Q10 supplements reduce these adverse effects.

HMG-CoA reductase inhibitors can reduce serum coenzyme Q10 levels. They block the synthesis of mevalonic acid, which is a precursor of coenzyme Q10, in a dose-dependent manner. Taking atorvastatin 80 mg daily for 30 days reduces coenzyme Q10 serum levels by 52%, but atorvastatin 10 mg daily or pravastatin 20 mg daily do not have this effect in healthy people. In other research, taking simvastatin 20 mg daily for 4 weeks reduces serum coenzyme Q10 levels by about 32%, but muscle levels increase by 47%. Since coenzyme Q10 is transported with low-density lipoprotein (LDL) cholesterol, reduction in LDL cholesterol levels by a statin may increase the amount of free coenzyme Q10 in the blood that is available for uptake into muscles. There is no reliable evidence that statin adverse effects such as myopathy are linked to reduced coenzyme Q10 levels in the blood, or that taking coenzyme Q10 supplements reduces statin side effects.
Taking Fluvastatin? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it plays a role in keeping muscles and the heart working properly. Fluvastatin, like other statins, works by blocking a liver pathway called HMG-CoA reductase, and that same pathway happens to be involved in making coenzyme Q10 naturally in the body, so blood levels can drop. That said, the evidence here is genuinely unclear: researchers are not yet sure whether this blood-level change actually causes any problems, or whether taking a supplement fixes anything. If you are curious or have concerns, it is worth bringing up with your pharmacist or doctor.

References (12)
  1. Folkers K, Langsjoen P, Willis R, et al. Lovastatin decreases coenzyme Q levels in humans. Proc Natl Acad Sci USA 1990;87:8931-4. PubMed
  2. Mortensen SA, Leth A, Agner E, et al. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med 1997;18:S137-44. PubMed
  3. Ghirlanda G, Oradei A, Manto A, et al. Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: A double blind, placebo-controlled study. J Clin Pharmacol 1993;33:226-9. PubMed
  4. De Pinieux G, Chariot P, Ammi-Said M, et al. Lipid-lowering drugs and mitochondrial function: Effects of HMG-CoA Reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Br J Clin Pharmacol 1996;42:333-7. PubMed
  5. Bargossi AM, Grossi G, Fiorella PL, et al. Exogenous CoQ10 supplementation prevents plasma ubiquinone reduction induced by HMG-CoA reductase inhibitors. Mol Aspects Med 1994;15:187-93. PubMed
  6. Watts GF, Castelluccio C, Rice-Evans C, et al. Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin. J Clin Pathol 1993;46:1055-7.
  7. Hanaki Y, Sugiyama S, Ozawa T, et al. Coenzyme Q10 and coronary artery disease. Clin Investig 1993;71:112-5. PubMed
  8. Berthold HK, Naini A, Di Mauro S, et al. Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial. Drug Saf 2006;29:703-12. PubMed
  9. Fuke C, Krikorian SA, Couris RR. Coenzyme Q10: A review of essential functions and clinical trials. US Pharm 2000;25:28-41.
  10. Bleske BE, Willis RA, Anthony M, et al. The effect of pravastatin and atorvastatin on coenzyme Q10. Am Heart J 2001;142:E2. PubMed
  11. Rundek T, Naini A, Sacco R, et al. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. Arch Neurol 2004;61:889-92.. PubMed
  12. Laaksonen R, Jokelainen K, Sahi T, et al. Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans. Clin Pharmacol Ther 1995;57:62-6. PubMed

Full nutrient report for Fluvastatin →

Fosinopril

Insufficient Evidence

Brand names include Monopril

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Fosinopril? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and your heart muscle is especially dependent on it. Fosinopril is an ACE inhibitor, and while it works differently than beta blockers, some antihypertensive drugs as a class have been reported to interfere with the enzymes that help your body make its own CoQ10. That said, the evidence here is truly insufficient, meaning researchers simply do not yet know whether this matters in a real, practical way for patients. If you are curious or have concerns, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Fosinopril →

Fosinopril, Hydrochlorothiazide

Insufficient Evidence

Brand names include Monopril HCT

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Fosinopril, Hydrochlorothiazide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Some antihypertensive medications have been reported to interfere with enzymes involved in the body's own production of coenzyme Q10, which could nudge levels slightly lower over time. That said, the evidence here is really thin, and no one has clearly shown this matters for people taking fosinopril or hydrochlorothiazide. If you are curious whether your levels are a concern, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Fosinopril, Hydrochlorothiazide →

Furosemide

Insufficient Evidence

Brand names include Lasix

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Furosemide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your body makes that helps cells produce energy and acts as an antioxidant. Some antihypertensive medications have been reported to interfere with the enzymes that keep CoQ10 levels normal, though it is not fully clear whether furosemide specifically drives this effect or how much it matters in practice. With only insufficient evidence here, there is no reason to be alarmed, and most people taking furosemide do not need to act on this. If you are curious about your levels or whether a supplement makes sense for you, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Furosemide →

Guanabenz Acetate

Insufficient Evidence

Brand names include Wytensin

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Guanabenz Acetate? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and your heart muscle relies on it quite a bit. A handful of blood-pressure medications have been noted to interfere with the enzymes that make coenzyme Q10 in the body, and guanabenz may fall into that category. That said, the evidence here is really thin, so nobody can say yet whether this matters in a meaningful way for people taking it. If you have questions or want to keep an eye on it, a quick conversation with your pharmacist or doctor is the right place to start.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Guanabenz Acetate →

Guanadrel Sulfate

Insufficient Evidence

Brand names include Hylorel

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Guanadrel Sulfate? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Some antihypertensive medications, guanadrel included, have been loosely linked to lower CoQ10 levels, possibly by interfering with the enzymes your body uses to make it. That said, the evidence here is genuinely insufficient, meaning researchers simply do not yet know whether this matters clinically. Most people taking guanadrel do not need to act on this, but if you are curious about your CoQ10 status, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Guanadrel Sulfate →

Guanethidine Monosulfate

Insufficient Evidence

Brand names include Ismelin, Isimil

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Guanethidine Monosulfate? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also works as an antioxidant to protect tissues. There is some research suggesting that certain blood pressure medications may interfere with the enzymes that keep coenzyme Q10 levels normal in the body, and guanethidine falls into that general category. That said, the evidence here is really thin, so this is considered an area of uncertainty rather than a proven concern. If you are curious about it, a quick conversation with your pharmacist or doctor is the right move.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Guanethidine Monosulfate →

Guanethidine, Hydrochlorothiazide

Insufficient Evidence

Brand names include Esimil

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Guanethidine, Hydrochlorothiazide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Some antihypertensive medications, possibly including guanethidine and hydrochlorothiazide, have been reported to interfere with the enzymes that help your body make or use coenzyme Q10, which could modestly reduce its levels. That said, the evidence here is really thin, and no one has clearly shown this causes any practical health problem. If you are curious whether this matters for you personally, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Guanethidine, Hydrochlorothiazide →

Guanfacine

Insufficient Evidence

Brand names include Tenex

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Guanfacine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a naturally made compound your body uses to produce energy inside cells and support heart muscle function. Some blood pressure medications have been reported to interfere with the enzymes that make coenzyme Q10, which could modestly lower the amount your body produces. Where guanfacine fits in that picture is genuinely unclear, since the evidence for this drug specifically is too limited to draw any firm conclusions. If you have been on guanfacine long-term and are curious, it is a reasonable thing to bring up with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Guanfacine →

Hydralazine

Insufficient Evidence

Brand names include Apresoline, Hylazin, Dralzine

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Hydralazine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Hydralazine appears to interfere with certain enzymes involved in making or using coenzyme Q10 in the body, which could nudge levels down slightly. That said, the evidence here is really thin, and right now no one knows whether this small change causes any real-world problems. If you have concerns, it is worth a quick conversation with your pharmacist or doctor before adding any supplement.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Hydralazine →

Hydralazine, Hydrochlorothiazide

Insufficient Evidence

Brand names include Apresoline-Esidrix, Apresazide

Thiazides can modestly decrease endogenous levels of coenzyme Q10.

Thiazide diuretics might decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to thiazide c side effects.
Taking Hydralazine, Hydrochlorothiazide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. Research suggests hydralazine may interfere with certain enzymes involved in CoQ10 activity, which could modestly reduce the body's own CoQ10 levels. That said, the evidence here is rated insufficient, meaning we really do not know whether this drop matters clinically or causes any noticeable effects. If you are curious about it, a quick conversation with your pharmacist or doctor is the right place to start.

References (1)
  1. LaValle JB. Hidden disruptions in metabolic syndrome: drug-induced nutrient depletion as a pathway to accelerated pathophysiology of metabolic syndrome. Altern Ther Health Med. 2006 Mar-Apr;12(2):26-31; quiz 32-3.

Full nutrient report for Hydralazine, Hydrochlorothiazide →

Brand names include Ser-Ap-Es, Unipres, Uniserp

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Hydralazine, Hydrochlorothiazide, Reserpine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your body makes that helps cells produce energy, and it also acts as an antioxidant. The hydrochlorothiazide in this combination pill has been linked to modest reductions in the body's own CoQ10 levels, though researchers aren't sure exactly why. Here's the reassuring part: the evidence on this is quite thin, and there's no solid proof that this small dip causes any real health problem or contributes to side effects. Most people on this medication don't need to take any action, but if you're curious whether a CoQ10 supplement makes sense for you, it's worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Hydralazine, Hydrochlorothiazide, Reserpine →

Hydralazine, Reserpine

Insufficient Evidence

Brand names include Serpasil-Apresoline1, Serpasil-Apresoline2

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Hydralazine, Reserpine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your body makes naturally that helps cells produce energy and acts as an antioxidant. Hydralazine appears to interfere with certain enzymes involved in coenzyme Q10 activity, which may nudge levels down a bit, though researchers are still not sure this difference is meaningful in practice. Right now the evidence is simply too thin to know whether people taking hydralazine need to worry about this at all. If you are curious whether a coenzyme Q10 supplement makes sense for you, it is worth a conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Hydralazine, Reserpine →

Hydrochlorothiazide

Insufficient Evidence

Brand names include Esidrix, Hydro, Microzide

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Hydrochlorothiazide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and some research suggests thiazide diuretics like hydrochlorothiazide may modestly reduce the body's own levels of it. The leading theory is that the drug may interfere with a shared biochemical pathway the body uses to make CoQ10 on its own, though exactly how this happens is still not fully understood. That said, the evidence here is genuinely thin, and there is no good data showing this modest dip actually causes problems or contributes to any side effects. For now, most people on hydrochlorothiazide do not need to act on this, but if you are curious about your situation specifically, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Hydrochlorothiazide →

Hydrochlorothiazide, Irbesartan

Insufficient Evidence

Brand names include Avalide

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Hydrochlorothiazide, Irbesartan? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and your heart muscle in particular depends on it. Some blood pressure medications have been linked to a mild drop in the body's own CoQ10 levels, possibly by interfering with the enzymes that make or activate it, though exactly how hydrochlorothiazide and irbesartan fit into that picture is not well established. With an 'Insufficient Evidence' rating, this is more of an open question than a proven concern, so most people taking these medications do not need to act on it. If you're curious whether CoQ10 is worth discussing for your situation, your pharmacist or doctor is a good place to start.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Hydrochlorothiazide, Irbesartan →

Hydrochlorothiazide, Labetalol

Insufficient Evidence

Brand names include Trandate HCT

Thiazides can modestly decrease endogenous levels of coenzyme Q10.

Thiazide diuretics might decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to thiazide c side effects.
Taking Hydrochlorothiazide, Labetalol? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and some early research suggests hydrochlorothiazide, a thiazide diuretic, may modestly lower the body's own levels of it. The exact reason is not fully understood, but it may relate to how thiazides affect cellular metabolism over time. That said, the evidence here is rated insufficient, meaning researchers simply do not yet know whether this small change makes any real difference to how you feel or function. If you have questions about whether monitoring or supplementing makes sense for you, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. LaValle JB. Hidden disruptions in metabolic syndrome: drug-induced nutrient depletion as a pathway to accelerated pathophysiology of metabolic syndrome. Altern Ther Health Med. 2006 Mar-Apr;12(2):26-31; quiz 32-3.

Full nutrient report for Hydrochlorothiazide, Labetalol →

Hydrochlorothiazide, Lisinopril

Insufficient Evidence

Brand names include Zestoretic, Prinzide

Thiazides can modestly decrease endogenous levels of coenzyme Q10.

Thiazide diuretics might decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to thiazide c side effects.
Taking Hydrochlorothiazide, Lisinopril? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. The thiazide component of this combination, hydrochlorothiazide, has been reported to modestly lower the body's own coenzyme Q10 levels, though researchers are not certain exactly why this happens. Here is the reassuring part: the evidence is thin, and there is no solid proof this small dip actually causes any health problems or side effects. That said, if you are curious whether this applies to your situation, it is worth bringing up with your pharmacist or doctor.

References (1)
  1. LaValle JB. Hidden disruptions in metabolic syndrome: drug-induced nutrient depletion as a pathway to accelerated pathophysiology of metabolic syndrome. Altern Ther Health Med. 2006 Mar-Apr;12(2):26-31; quiz 32-3.

Full nutrient report for Hydrochlorothiazide, Lisinopril →

Brand names include Hyzaar

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Hydrochlorothiazide, Losartan Potassium? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. Some antihypertensive drugs have been shown to interfere with the enzymes that make coenzyme Q10 in the body, which could nudge levels down a little. For this combination, though, the evidence is thin and the clinical meaning is simply not known yet. Most people taking these medications do not need to act on this, but if you are curious about your coenzyme Q10 levels, your doctor or pharmacist is a good place to start that conversation.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Hydrochlorothiazide, Losartan Potassium →

Hydrochlorothiazide, Methyldopa

Insufficient Evidence

Brand names include Aldoril 15, Methazide, Aldoril 25

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Hydrochlorothiazide, Methyldopa? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Some research suggests hydrochlorothiazide, a thiazide diuretic, may modestly reduce the body's own CoQ10 levels, though exactly how this happens is not fully understood. Here is the reassuring part: the evidence is currently insufficient to know whether this reduction matters in a real, everyday sense, and there is no solid proof it causes any noticeable side effects. If you have concerns, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Hydrochlorothiazide, Methyldopa →

Hydrochlorothiazide, Metoprolol

Insufficient Evidence

Brand names include Lopressor HCT

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Hydrochlorothiazide, Metoprolol? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. Beta blockers like metoprolol appear to interfere with the enzymes that make or use coenzyme Q10 in the body, which may modestly reduce its levels over time. That said, the evidence here is genuinely thin, and researchers have not confirmed that this drop causes any real-world problems. If you are curious whether this applies to you, it is a good question to raise with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Hydrochlorothiazide, Metoprolol →

Hydrochlorothiazide, Moexipril

Insufficient Evidence

Brand names include Uniretic

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Hydrochlorothiazide, Moexipril? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to generate energy, and the heart muscle relies on it quite a bit. Some antihypertensive medications have been reported to interfere with the enzymes that make coenzyme Q10 in the body, which could modestly lower your internal supply over time. That said, the evidence here is really thin, and no one has clearly shown this matters clinically for people taking this combination. If you are curious whether a coenzyme Q10 supplement makes sense for you, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Hydrochlorothiazide, Moexipril →

Hydrochlorothiazide, Pindolol

Insufficient Evidence

Brand names include Viskazide

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Hydrochlorothiazide, Pindolol? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and your heart muscle relies on it heavily. Pindolol belongs to the beta blocker class, and some research suggests beta blockers may interfere with the enzymes your body uses to make coenzyme Q10, which could nudge levels down over time. That said, the evidence here is genuinely thin, and no one has shown this translates into real symptoms or problems for patients. If you are curious whether this matters for you personally, it is worth bringing up with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Hydrochlorothiazide, Pindolol →

Hydrochlorothiazide, Propranolol

Insufficient Evidence

Brand names include Inderide

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Hydrochlorothiazide, Propranolol? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. Propranolol, the beta blocker in this combination, has been reported to interfere with the enzymes your body uses to make CoQ10 on its own, which could nudge levels down over time. That said, the evidence here is rated insufficient, meaning researchers simply do not yet know whether this matters in a real, practical way for most people taking these medications. If you are curious about your levels or whether a supplement makes sense for you, it is worth bringing up with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Hydrochlorothiazide, Propranolol →

Hydrochlorothiazide, Quinapril

Insufficient Evidence

Brand names include Accuretic

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Hydrochlorothiazide, Quinapril? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Some blood pressure medications have been reported to mildly interfere with the enzymes that make or use coenzyme Q10 in the body, which could nudge levels down a bit. That said, the evidence here is quite thin, and it is genuinely unclear whether any drop matters in a real-world sense. This is not something to worry about on your own, but if you are curious, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Hydrochlorothiazide, Quinapril →

Hydrochlorothiazide, Reserpine

Insufficient Evidence

Brand names include Hydropres, Serpasil-Esidrix, Serpasil-Esidrix #1

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Hydrochlorothiazide, Reserpine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also works as an antioxidant. Some blood pressure medications appear to interfere with certain enzymes involved in the body's own CoQ10 production, which could nudge levels slightly lower. That said, the evidence for this combination is truly limited, and right now there is no solid proof this matters in real life for most people taking it. If you are curious, a quick chat with your pharmacist or doctor can help you decide whether any monitoring makes sense for you.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Hydrochlorothiazide, Reserpine →

Hydrochlorothiazide, Spironolactone

Insufficient Evidence

Brand names include Spirozine, Aldactazide, Aldactide 25

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Hydrochlorothiazide, Spironolactone? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Some research suggests that thiazide diuretics like hydrochlorothiazide may modestly reduce the body's own CoQ10 levels, though the exact reason is not fully understood. Here's the reassuring part: the evidence is thin, and there's no solid proof this small dip actually causes any symptoms or side effects. If you're curious whether CoQ10 is worth discussing for your situation, your pharmacist or doctor is a good place to start that conversation.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Hydrochlorothiazide, Spironolactone →

Hydrochlorothiazide, Timolol

Insufficient Evidence

Brand names include Timolide

Thiazides can modestly decrease endogenous levels of coenzyme Q10.

Thiazide diuretics might decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to thiazide c side effects.
Taking Hydrochlorothiazide, Timolol? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and some research suggests thiazide diuretics like hydrochlorothiazide may modestly reduce the body's own supply of it, possibly by interfering with how the body makes it. That said, the evidence here is really thin, and no one has shown this small reduction actually causes problems in people taking the medication. Right now, most patients on hydrochlorothiazide don't need to do anything specific about this, but if you're curious whether a supplement makes sense for you, it's worth a quick conversation with your pharmacist or doctor.

References (1)
  1. LaValle JB. Hidden disruptions in metabolic syndrome: drug-induced nutrient depletion as a pathway to accelerated pathophysiology of metabolic syndrome. Altern Ther Health Med. 2006 Mar-Apr;12(2):26-31; quiz 32-3.

Full nutrient report for Hydrochlorothiazide, Timolol →

Hydrochlorothiazide, Triamterene

Insufficient Evidence

Brand names include Maxzide, Dyazide, Maxzide-25

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Hydrochlorothiazide, Triamterene? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. The thiazide component of this combination pill has been loosely linked to modest reductions in the body's own CoQ10 levels, though researchers aren't sure exactly how it happens. Here's the reassuring part: the evidence is currently too limited to know whether this drop matters clinically, and no solid research ties it to any real side effects. Most people taking this medication do not need to act on this, but if you're curious or have concerns, it's worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Hydrochlorothiazide, Triamterene →

Hydrochlorothiazide, Valsartan

Insufficient Evidence

Brand names include Diovan HCT

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Hydrochlorothiazide, Valsartan? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your body makes that helps cells produce energy and acts as an antioxidant. Some blood pressure medications have been linked to modest reductions in the body's own CoQ10 levels, possibly by interfering with the enzymes that produce it, though exactly how hydrochlorothiazide and valsartan affect this is not well understood. Honestly, the evidence here is thin, and there is no solid proof this matters clinically or causes noticeable side effects. If you are curious whether CoQ10 is something worth discussing for your situation, bring it up with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Hydrochlorothiazide, Valsartan →

Hydroflumethiazide

Insufficient Evidence

Brand names include Saluron

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Hydroflumethiazide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and the heart muscle relies on it quite a bit. Some blood pressure medications, hydroflumethiazide included, have been loosely linked to lower CoQ10 levels, possibly by interfering with the enzymes your body uses to make it. That said, the evidence here is genuinely thin, and no one has shown this actually causes problems for people taking these drugs. If you have concerns, it is worth mentioning to your pharmacist or doctor, but there is no clear reason to worry right now.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Hydroflumethiazide →

Hydroflumethiazide, Reserpine

Insufficient Evidence

Brand names include Salutensin-Demi, Salutensin

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Hydroflumethiazide, Reserpine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a substance your body makes naturally that helps cells produce energy, and some research suggests thiazide diuretics like hydroflumethiazide may modestly reduce those internal levels over time. The honest truth, though, is that we do not fully understand why this happens or whether it matters clinically. For most people taking this medication, there is currently no solid evidence that this small change causes any noticeable problem. Still, if you are curious or have concerns, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Hydroflumethiazide, Reserpine →

Iloprost

Insufficient Evidence

Brand names include Ventavis, Aurlumyn

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Iloprost? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Iloprost is a prostacyclin medication used for conditions like pulmonary arterial hypertension, and like some other drugs that affect blood pressure, it may interfere with the enzymes your body uses to make coenzyme Q10, potentially nudging levels down a little. That said, the evidence here is genuinely thin, and no one has shown this matters in a real clinical way for patients. If you are curious whether this applies to you, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Iloprost →

Imipramine

Insufficient Evidence

Brand names include Tofranil, Tofranil PM

Tricyclic antidepressants can modestly decrease endogenous levels of coenzyme Q10.

Tricyclic antidepressants might inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to tricyclic antidepressant side effects.
Taking Imipramine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. Some research suggests that tricyclic antidepressants like imipramine may interfere with the enzymes that help your body make or use CoQ10, leading to modestly lower levels. That said, the evidence here is really thin, and no one has shown this actually causes problems in people taking the medication. If you are curious, it is worth a quick conversation with your pharmacist or doctor before considering anything further.

References (1)
  1. Garrido-Maraver J, Cordero MD, Oropesa-Ávila M, et al. Coenzyme Q10 therapy. Mol Syndromol. 2014;5(3-4):187-97.

Full nutrient report for Imipramine →

Indapamide

Insufficient Evidence

Brand names include Lozol, Lozide

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Indapamide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your body makes that helps cells produce energy and may support heart muscle function. Some blood pressure medications have been linked to lower CoQ10 activity, possibly by interfering with the enzymes your body uses to make it, though whether indapamide specifically does this is not well studied. The evidence here is genuinely thin, so there is no need to worry or act on this right now. If you are curious whether a CoQ10 supplement makes sense for you, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Indapamide →

Irbesartan

Insufficient Evidence

Brand names include Avapro, Aprovel

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Irbesartan? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Some antihypertensive medications have been linked to mildly lower levels of it, possibly by interfering with the enzymes your body uses to make it, though exactly how irbesartan specifically fits into that picture is not well established. Right now the evidence is simply too limited to know whether this matters in a practical way for people taking irbesartan. If you are curious about your levels or thinking about a supplement, that is a good conversation to have with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Irbesartan →

Irbesartan, Hydrochlorothiazide

Insufficient Evidence

Brand names include CoAprovel

Thiazides can modestly decrease endogenous levels of coenzyme Q10.

Thiazide diuretics might decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to thiazide c side effects.
Taking Irbesartan, Hydrochlorothiazide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. The hydrochlorothiazide portion of this combination pill has been reported to modestly reduce the body's own CoQ10 levels, though exactly how is not fully understood. Because the evidence here is rated as insufficient, we simply don't know yet whether this small dip is meaningful in any practical way. If you have concerns, it's worth bringing up with your pharmacist or doctor at your next visit.

References (1)
  1. LaValle JB. Hidden disruptions in metabolic syndrome: drug-induced nutrient depletion as a pathway to accelerated pathophysiology of metabolic syndrome. Altern Ther Health Med. 2006 Mar-Apr;12(2):26-31; quiz 32-3.

Full nutrient report for Irbesartan, Hydrochlorothiazide →

Isosorbide Dinitrate, Hydralazine

Insufficient Evidence

Brand names include BiDil

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Isosorbide Dinitrate, Hydralazine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Hydralazine, one of the two drugs in this combination, appears to interfere with enzymes that help your body make or use coenzyme Q10, which could nudge levels down over time. That said, the evidence here is really preliminary, and right now it is not clear whether any drop in levels actually causes problems in real patients. If you have questions or are thinking about a CoQ10 supplement, your pharmacist or doctor is the right person to talk it through with.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Isosorbide Dinitrate, Hydralazine →

Isradipine

Insufficient Evidence

Brand names include Dynacirc CR

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Isradipine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and your heart muscle relies on it heavily. Some antihypertensive medications have been reported to interfere with the enzymes that make or use coenzyme Q10 in the body, and isradipine falls into this broader drug class, though exactly how strong this effect is for isradipine specifically is not well understood. The evidence here is genuinely insufficient, so there is no solid reason to worry right now. That said, if you are curious about your levels or whether a supplement makes sense for you, it is worth a conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Isradipine →

Labetalol

Insufficient Evidence

Brand names include Normodyne, Trandate

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Labetalol? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and the heart muscle in particular depends on it. Labetalol is a beta blocker, and there is some research suggesting beta blockers may partially interfere with the enzymes your body uses to make its own CoQ10, potentially nudging levels a bit lower over time. That said, the current evidence is genuinely thin, so nobody knows yet whether this drop is large enough to matter clinically. If you are a long-term labetalol user and are curious, it is a perfectly reasonable question to bring up with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Labetalol →

Lercanidipine hydrochloride

Insufficient Evidence

Brand names include Zanidip

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Lercanidipine hydrochloride? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and the heart muscle relies on it quite a bit. Some antihypertensive medications have been linked to modest drops in the body's own CoQ10 levels, possibly by interfering with the enzymes that make it, though it is not fully clear whether lercanidipine specifically does this or whether the drop matters clinically. The evidence here is listed as insufficient, meaning researchers simply have not studied this combination enough to draw firm conclusions. If you have been on lercanidipine long-term and are curious, it is worth a quick conversation with your pharmacist or doctor rather than acting on your own.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Lercanidipine hydrochloride →

Levamlodipine

Insufficient Evidence

Brand names include Conjupri

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Levamlodipine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a substance your body makes naturally that helps cells produce energy and acts as an antioxidant. Levamlodipine is a calcium channel blocker used to lower blood pressure, and some blood pressure medications have been reported to interfere with the enzymes that produce coenzyme Q10, potentially nudging levels down a bit. That said, the current evidence for this with levamlodipine specifically is quite thin, and no one has shown this translates into real health problems. If you are curious whether this applies to you, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Levamlodipine →

Lisinopril

Insufficient Evidence

Brand names include Zestril, Prinivil, Qbrelis

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Lisinopril? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. Some antihypertensive medications have been linked to modest reductions in the body's own CoQ10 levels, possibly by interfering with certain enzymes involved in making or using it. For lisinopril specifically, the picture is unclear, and right now there simply is not enough evidence to know whether this matters in practice. If you are curious whether CoQ10 is worth discussing for your situation, bring it up with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Lisinopril →

Lofepramine

Insufficient Evidence

Brand names include Feprapax, Lomont, Gamanil

Tricyclic antidepressants can modestly decrease endogenous levels of coenzyme Q10.

Tricyclic antidepressants might inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to tricyclic antidepressant side effects.
Taking Lofepramine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Lofepramine, like other tricyclic antidepressants, may interfere with enzymes involved in coenzyme Q10 activity, which could modestly reduce the body's own levels. That said, the evidence here is genuinely thin, and nobody has clearly shown this causes real health problems in people taking these medications. If you are curious or have concerns, it is worth raising with your pharmacist or doctor.

References (1)
  1. Garrido-Maraver J, Cordero MD, Oropesa-Ávila M, et al. Coenzyme Q10 therapy. Mol Syndromol. 2014;5(3-4):187-97.

Full nutrient report for Lofepramine →

Losartan Potassium

Insufficient Evidence

Brand names include Cozaar

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Losartan Potassium? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is something your body makes on its own, and your cells use it to produce energy. With losartan, there is a loose idea that blood pressure medications as a class might interfere with the enzymes that make CoQ10, though the research on losartan specifically is thin and no one has clearly shown it causes a meaningful drop. The evidence here is simply too limited to know whether this matters in practice, so most people taking losartan do not need to act on this right now. If you are curious about your CoQ10 levels or whether a supplement makes sense for you, that is a good conversation to have with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Losartan Potassium →

Lovastatin

Insufficient Evidence

Brand names include Mevacor, Altocor

Statins can halt the synthesis of coenzyme Q10, reducing endogenous levels. However, it is not clear whether this contributes to statin adverse effects, or if coenzyme Q10 supplements reduce these adverse effects.

HMG-CoA reductase inhibitors can reduce serum coenzyme Q10 levels. They block the synthesis of mevalonic acid, which is a precursor of coenzyme Q10, in a dose-dependent manner. Taking atorvastatin 80 mg daily for 30 days reduces coenzyme Q10 serum levels by 52%, but atorvastatin 10 mg daily or pravastatin 20 mg daily do not have this effect in healthy people. In other research, taking simvastatin 20 mg daily for 4 weeks reduces serum coenzyme Q10 levels by about 32%, but muscle levels increase by 47%. Since coenzyme Q10 is transported with low-density lipoprotein (LDL) cholesterol, reduction in LDL cholesterol levels by a statin may increase the amount of free coenzyme Q10 in the blood that is available for uptake into muscles. There is no reliable evidence that statin adverse effects such as myopathy are linked to reduced coenzyme Q10 levels in the blood, or that taking coenzyme Q10 supplements reduces statin side effects.
Taking Lovastatin? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and lovastatin works by blocking a liver pathway that happens to make CoQ10 as well as cholesterol. So there is a real biological reason to think lovastatin could lower CoQ10 levels in the blood. That said, researchers are still unsure whether this matters in practice, and right now the evidence is simply not strong enough to draw firm conclusions. If you have questions about whether any monitoring or supplementation makes sense for you personally, that is a great conversation to have with your pharmacist or doctor.

References (12)
  1. Folkers K, Langsjoen P, Willis R, et al. Lovastatin decreases coenzyme Q levels in humans. Proc Natl Acad Sci USA 1990;87:8931-4. PubMed
  2. Mortensen SA, Leth A, Agner E, et al. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med 1997;18:S137-44. PubMed
  3. Ghirlanda G, Oradei A, Manto A, et al. Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: A double blind, placebo-controlled study. J Clin Pharmacol 1993;33:226-9. PubMed
  4. De Pinieux G, Chariot P, Ammi-Said M, et al. Lipid-lowering drugs and mitochondrial function: Effects of HMG-CoA Reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Br J Clin Pharmacol 1996;42:333-7. PubMed
  5. Bargossi AM, Grossi G, Fiorella PL, et al. Exogenous CoQ10 supplementation prevents plasma ubiquinone reduction induced by HMG-CoA reductase inhibitors. Mol Aspects Med 1994;15:187-93. PubMed
  6. Watts GF, Castelluccio C, Rice-Evans C, et al. Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin. J Clin Pathol 1993;46:1055-7.
  7. Hanaki Y, Sugiyama S, Ozawa T, et al. Coenzyme Q10 and coronary artery disease. Clin Investig 1993;71:112-5. PubMed
  8. Berthold HK, Naini A, Di Mauro S, et al. Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial. Drug Saf 2006;29:703-12. PubMed
  9. Fuke C, Krikorian SA, Couris RR. Coenzyme Q10: A review of essential functions and clinical trials. US Pharm 2000;25:28-41.
  10. Bleske BE, Willis RA, Anthony M, et al. The effect of pravastatin and atorvastatin on coenzyme Q10. Am Heart J 2001;142:E2. PubMed
  11. Rundek T, Naini A, Sacco R, et al. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. Arch Neurol 2004;61:889-92.. PubMed
  12. Laaksonen R, Jokelainen K, Sahi T, et al. Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans. Clin Pharmacol Ther 1995;57:62-6. PubMed

Full nutrient report for Lovastatin →

Macitentan

Insufficient Evidence

Brand names include Opsumit

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Macitentan? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a naturally made compound your cells use to produce energy and protect themselves from damage. Macitentan is a blood pressure medication for pulmonary arterial hypertension, and like some other antihypertensives, it may interfere with the enzymes your body uses to make CoQ10, possibly nudging levels down a little. That said, the evidence here is genuinely thin, and right now nobody knows if this small change actually matters in practice. If you are curious or have been on macitentan long term, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Macitentan →

Macitentan, Tadalafil

Insufficient Evidence

Brand names include Opsynvi

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Macitentan, Tadalafil? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. Some antihypertensive medications have been loosely linked to mildly lower CoQ10 levels, possibly by interfering with the enzymes your body uses to make it. For macitentan and tadalafil specifically, the evidence is thin and the clinical significance is simply not known. Most people taking these medications do not need to act on this, but if you are curious whether CoQ10 is worth discussing for your situation, your pharmacist or doctor is a great place to start.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Macitentan, Tadalafil →

Mannitol

Insufficient Evidence

Brand names include Osmitrol, Bronchitol

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Mannitol? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Mannitol is primarily used as an osmotic agent rather than a classic antihypertensive, so the concern here really stems from a broader observation that some blood-pressure drugs may interfere with enzymes the body needs to make coenzyme Q10. Right now the evidence is simply too thin to know whether this matters for mannitol users specifically. If you have questions about your levels or whether a supplement makes sense, a quick conversation with your pharmacist or doctor is the right place to start.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Mannitol →

Mecamylamine

Insufficient Evidence

Brand names include Inversine

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Mecamylamine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy and protect themselves from damage. Some blood pressure medications, including older ones like mecamylamine, have been loosely associated with slightly lower CoQ10 levels, possibly by interfering with the enzymes your body uses to make it. That said, the evidence here is genuinely thin, and there is no clear proof this reduction causes any real harm. If you have concerns, it is worth a quick chat with your pharmacist or doctor before considering anything.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Mecamylamine →

Methazolamide

Insufficient Evidence

Brand names include Neptazane

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Methazolamide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and the heart muscle in particular depends on healthy levels of it. Methazolamide belongs to a drug class that, in some studies, appears to interfere with the enzymes that help your body make or use CoQ10, which could nudge levels downward over time. That said, the evidence here is genuinely insufficient, meaning researchers simply do not yet know whether this matters in practice for people taking methazolamide. If you have been on this medication long term and are curious, it is worth bringing up with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Methazolamide →

Methyclothiazide

Insufficient Evidence

Brand names include Enduron, Aquatensen

Thiazides can modestly decrease endogenous levels of coenzyme Q10.

Thiazide diuretics might decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to thiazide c side effects.
Taking Methyclothiazide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a naturally made compound your cells use to produce energy, and some research suggests thiazide diuretics like methyclothiazide may modestly reduce the body's own levels of it, possibly by interfering with how the body synthesizes it internally. That said, the evidence here is genuinely thin, and there is no good proof this small dip causes any real symptoms or problems. For most people taking this medication, this is not something to lose sleep over, though if you are curious about your levels or considering a supplement, a quick chat with your pharmacist or doctor is the right move.

References (1)
  1. LaValle JB. Hidden disruptions in metabolic syndrome: drug-induced nutrient depletion as a pathway to accelerated pathophysiology of metabolic syndrome. Altern Ther Health Med. 2006 Mar-Apr;12(2):26-31; quiz 32-3.

Full nutrient report for Methyclothiazide →

Methyclothiazide, Pargyline

Insufficient Evidence

Brand names include Eutron

Thiazides can modestly decrease endogenous levels of coenzyme Q10.

Thiazide diuretics might decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to thiazide c side effects.
Taking Methyclothiazide, Pargyline? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Methyclothiazide, a thiazide-type diuretic, has been loosely linked to modest dips in the body's own CoQ10 levels, though researchers aren't certain exactly why this happens. The evidence here is rated insufficient, meaning there simply isn't enough solid data yet to know whether this matters in practice. Most people taking this medication don't need to act on this, but if you're curious or have concerns, it's worth a quick conversation with your pharmacist or doctor.

References (1)
  1. LaValle JB. Hidden disruptions in metabolic syndrome: drug-induced nutrient depletion as a pathway to accelerated pathophysiology of metabolic syndrome. Altern Ther Health Med. 2006 Mar-Apr;12(2):26-31; quiz 32-3.

Full nutrient report for Methyclothiazide, Pargyline →

Methyclothiazide, Reserpine

Insufficient Evidence

Brand names include Diutensen-R

Thiazides can modestly decrease endogenous levels of coenzyme Q10.

Thiazide diuretics might decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to thiazide c side effects.
Taking Methyclothiazide, Reserpine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. The thiazide component of this combination medication has been loosely linked to modest reductions in the body's own CoQ10 levels, possibly by interfering with how cells make it. That said, the evidence here is genuinely thin, and there is no good proof this translates into any real health problem for most people taking this drug. If you are curious whether this applies to you, it is worth a quick chat with your pharmacist or doctor.

References (1)
  1. LaValle JB. Hidden disruptions in metabolic syndrome: drug-induced nutrient depletion as a pathway to accelerated pathophysiology of metabolic syndrome. Altern Ther Health Med. 2006 Mar-Apr;12(2):26-31; quiz 32-3.

Full nutrient report for Methyclothiazide, Reserpine →

Methyldopa

Insufficient Evidence

Brand names include Aldomet

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Methyldopa? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Some blood pressure medications, possibly including methyldopa, appear to interfere with the enzymes your body relies on to make or use coenzyme Q10, which could nudge levels down slightly. That said, the evidence here is really thin, and right now there is no good proof this drop matters clinically or causes any noticeable problems. If you are curious whether this is worth paying attention to in your situation, it is a fine question to bring up with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Methyldopa →

Metolazone

Insufficient Evidence

Brand names include Diulo, Zaroxolyn, Mykrox

Thiazides can modestly decrease endogenous levels of coenzyme Q10.

Thiazide diuretics might decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to thiazide c side effects.
Taking Metolazone? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your body makes that helps cells produce energy, and some evidence suggests certain blood pressure medications may interfere with the enzymes that keep CoQ10 levels up. Metolazone belongs to that broader antihypertensive family, though exactly how it might affect CoQ10 is not well understood for this drug specifically. Honestly, the research here is still pretty thin, so there is no clear reason to worry or rush to take a supplement. If you are curious whether this is worth tracking in your situation, it is a great question to bring up with your pharmacist or doctor.

References (1)
  1. LaValle JB. Hidden disruptions in metabolic syndrome: drug-induced nutrient depletion as a pathway to accelerated pathophysiology of metabolic syndrome. Altern Ther Health Med. 2006 Mar-Apr;12(2):26-31; quiz 32-3.

Full nutrient report for Metolazone →

Metoprolol

Insufficient Evidence

Brand names include Lopressor, Toprol XL

Beta-blockers can decrease endogenous levels of coenzyme Q10.

Beta-blockers are thought to inhibit coenzyme Q10 mitochondrial enzymes and decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to beta-blocker side effects.
Taking Metoprolol? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it plays a role in keeping the heart and muscles working efficiently. Metoprolol, like other beta-blockers, may interfere with certain enzymes inside your cells that are involved in making coenzyme Q10, which could nudge your body's natural levels down a bit. That said, the evidence here is truly preliminary, and right now researchers do not know whether this small change actually causes any real problems. If you have concerns, it is worth bringing up with your pharmacist or doctor rather than starting a supplement on your own.

References (1)
  1. Kishi H, Kishi T, Folkers K. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q10 enzymes by clinically used anti-hypertensive drugs. Res Commun Chem Pathol Pharmacol 1975;12:533-40.

Full nutrient report for Metoprolol →

Minoxidil

Insufficient Evidence

Brand names include Loniten, Rogaine

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Minoxidil? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and the heart muscle relies on it heavily. Some antihypertensive medications, including minoxidil, have been linked to lower activity of enzymes involved in making coenzyme Q10 in the body, though exactly how minoxidil does this is not fully understood. Honestly, the evidence here is thin, and right now there is no solid proof this drop is meaningful or causes any real harm. If you are curious about it, a quick conversation with your pharmacist or doctor is the right place to start.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Minoxidil →

Moexipril

Insufficient Evidence

Brand names include Univasc

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Moexipril? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and your heart muscle relies on it quite a bit. Some antihypertensive medications have been linked to mildly lower CoQ10 levels, possibly by interfering with the enzymes your body uses to make it, though whether moexipril specifically does this is not well studied. The evidence here is rated insufficient, meaning we simply do not have enough reliable data to know if this matters in practice for most people taking moexipril. If you are curious or have concerns, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Moexipril →

Moxonidine

Insufficient Evidence

Brand names include Physiotens

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Moxonidine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Some antihypertensive medicines have been reported to interfere with the enzymes that make or activate CoQ10, which could nudge levels down a bit, though whether moxonidine specifically does this is genuinely unclear. The evidence here is rated insufficient, meaning researchers simply do not have enough data yet to know if this matters in practice for people taking moxonidine. If you are curious or have concerns, it is worth raising with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Moxonidine →

Nadolol

Insufficient Evidence

Brand names include Corgard

Beta-blockers can decrease endogenous levels of coenzyme Q10.

Beta-blockers are thought to inhibit coenzyme Q10 mitochondrial enzymes and decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to beta-blocker side effects.
Taking Nadolol? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it plays a role in keeping the heart and muscles working properly. Nadolol belongs to a drug class called beta-blockers, and there is some evidence these medications may interfere with certain enzymes inside your cells that your body needs to make coenzyme Q10. That said, whether this actually causes a meaningful drop in levels is genuinely unknown right now, and there is no solid proof it leads to any real symptoms or problems. If you have questions or concerns, it is worth bringing up with your pharmacist or doctor.

References (1)
  1. Kishi H, Kishi T, Folkers K. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q10 enzymes by clinically used anti-hypertensive drugs. Res Commun Chem Pathol Pharmacol 1975;12:533-40.

Full nutrient report for Nadolol →

Nebivolol

Insufficient Evidence

Brand names include Bystolic, Nebilet

Beta-blockers can decrease endogenous levels of coenzyme Q10.

Beta-blockers are thought to inhibit coenzyme Q10 mitochondrial enzymes and decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to beta-blocker side effects.
Taking Nebivolol? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it plays a role in keeping the heart and muscles running efficiently. Nebivolol is a beta-blocker, and this class of medication is thought to interfere with certain enzymes inside your cells' mitochondria that the body needs to make CoQ10, which can nudge levels downward. That said, the current evidence is simply too limited to know whether this drop is meaningful in practice, and there is no solid proof it causes any real symptoms. If you are curious or concerned, it is worth bringing up with your pharmacist or doctor before considering any supplement.

References (1)
  1. Kishi H, Kishi T, Folkers K. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q10 enzymes by clinically used anti-hypertensive drugs. Res Commun Chem Pathol Pharmacol 1975;12:533-40.

Full nutrient report for Nebivolol →

Nebivolol Hydrochloride, Valsartan

Insufficient Evidence

Brand names include Byvalson

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Nebivolol Hydrochloride, Valsartan? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is something your body makes naturally and uses to produce energy inside cells, and your heart muscle relies on it heavily. The beta-blocker portion of this combination (nebivolol) has been reported to interfere with the enzymes your body uses to produce CoQ10, which may modestly reduce your natural levels over time. That said, the evidence here is rated insufficient, meaning researchers simply do not yet know whether this reduction causes any real-world problems. If you have been on this medication long-term and are curious, it is worth a conversation with your pharmacist or doctor before considering anything further.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Nebivolol Hydrochloride, Valsartan →

Niacin, Lovastatin

Insufficient Evidence

Brand names include Advicor

Statins can halt the synthesis of coenzyme Q10, reducing endogenous levels. However, it is not clear whether this contributes to statin adverse effects, or if coenzyme Q10 supplements reduce these adverse effects.

HMG-CoA reductase inhibitors can reduce serum coenzyme Q10 levels. They block the synthesis of mevalonic acid, which is a precursor of coenzyme Q10, in a dose-dependent manner. Taking atorvastatin 80 mg daily for 30 days reduces coenzyme Q10 serum levels by 52%, but atorvastatin 10 mg daily or pravastatin 20 mg daily do not have this effect in healthy people. In other research, taking simvastatin 20 mg daily for 4 weeks reduces serum coenzyme Q10 levels by about 32%, but muscle levels increase by 47%. Since coenzyme Q10 is transported with low-density lipoprotein (LDL) cholesterol, reduction in LDL cholesterol levels by a statin may increase the amount of free coenzyme Q10 in the blood that is available for uptake into muscles. There is no reliable evidence that statin adverse effects such as myopathy are linked to reduced coenzyme Q10 levels in the blood, or that taking coenzyme Q10 supplements reduces statin side effects.
Taking Niacin, Lovastatin? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Lovastatin works by blocking a step in the body's cholesterol-making pathway, and coenzyme Q10, a compound your cells use to produce energy, is made through that same pathway. Because of this overlap, statins like lovastatin can reduce the amount of coenzyme Q10 your body produces on its own. That said, the evidence here is genuinely unclear: blood levels may dip, but whether that affects how you feel or causes any harm is not well established. If you are curious about this or take lovastatin long-term, it is worth bringing up with your pharmacist or doctor.

References (12)
  1. Folkers K, Langsjoen P, Willis R, et al. Lovastatin decreases coenzyme Q levels in humans. Proc Natl Acad Sci USA 1990;87:8931-4. PubMed
  2. Mortensen SA, Leth A, Agner E, et al. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med 1997;18:S137-44. PubMed
  3. Ghirlanda G, Oradei A, Manto A, et al. Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: A double blind, placebo-controlled study. J Clin Pharmacol 1993;33:226-9. PubMed
  4. De Pinieux G, Chariot P, Ammi-Said M, et al. Lipid-lowering drugs and mitochondrial function: Effects of HMG-CoA Reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Br J Clin Pharmacol 1996;42:333-7. PubMed
  5. Bargossi AM, Grossi G, Fiorella PL, et al. Exogenous CoQ10 supplementation prevents plasma ubiquinone reduction induced by HMG-CoA reductase inhibitors. Mol Aspects Med 1994;15:187-93. PubMed
  6. Watts GF, Castelluccio C, Rice-Evans C, et al. Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin. J Clin Pathol 1993;46:1055-7.
  7. Hanaki Y, Sugiyama S, Ozawa T, et al. Coenzyme Q10 and coronary artery disease. Clin Investig 1993;71:112-5. PubMed
  8. Berthold HK, Naini A, Di Mauro S, et al. Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial. Drug Saf 2006;29:703-12. PubMed
  9. Fuke C, Krikorian SA, Couris RR. Coenzyme Q10: A review of essential functions and clinical trials. US Pharm 2000;25:28-41.
  10. Bleske BE, Willis RA, Anthony M, et al. The effect of pravastatin and atorvastatin on coenzyme Q10. Am Heart J 2001;142:E2. PubMed
  11. Rundek T, Naini A, Sacco R, et al. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. Arch Neurol 2004;61:889-92.. PubMed
  12. Laaksonen R, Jokelainen K, Sahi T, et al. Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans. Clin Pharmacol Ther 1995;57:62-6. PubMed

Full nutrient report for Niacin, Lovastatin →

Niacin, Simvastatin

Insufficient Evidence

Brand names include Simcor

Statins can halt the synthesis of coenzyme Q10, reducing endogenous levels. However, it is not clear whether this contributes to statin adverse effects, or if coenzyme Q10 supplements reduce these adverse effects.

HMG-CoA reductase inhibitors can reduce serum coenzyme Q10 levels. They block the synthesis of mevalonic acid, which is a precursor of coenzyme Q10, in a dose-dependent manner. Taking atorvastatin 80 mg daily for 30 days reduces coenzyme Q10 serum levels by 52%, but atorvastatin 10 mg daily or pravastatin 20 mg daily do not have this effect in healthy people. In other research, taking simvastatin 20 mg daily for 4 weeks reduces serum coenzyme Q10 levels by about 32%, but muscle levels increase by 47%. Since coenzyme Q10 is transported with low-density lipoprotein (LDL) cholesterol, reduction in LDL cholesterol levels by a statin may increase the amount of free coenzyme Q10 in the blood that is available for uptake into muscles. There is no reliable evidence that statin adverse effects such as myopathy are linked to reduced coenzyme Q10 levels in the blood, or that taking coenzyme Q10 supplements reduces statin side effects.
Taking Niacin, Simvastatin? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and simvastatin may reduce the amount your body makes. Here is why: statins work by blocking a liver pathway called HMG-CoA reductase, and that same pathway also happens to produce coenzyme Q10, so the medication can cut production as a side effect. That said, the evidence on whether this actually causes harm is genuinely unclear, and researchers are still debating whether lower blood levels even translate to a real problem in muscles or elsewhere. If you are curious about your personal situation, it is worth raising the question with your pharmacist or doctor rather than starting a supplement on your own.

References (12)
  1. Folkers K, Langsjoen P, Willis R, et al. Lovastatin decreases coenzyme Q levels in humans. Proc Natl Acad Sci USA 1990;87:8931-4. PubMed
  2. Mortensen SA, Leth A, Agner E, et al. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med 1997;18:S137-44. PubMed
  3. Ghirlanda G, Oradei A, Manto A, et al. Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: A double blind, placebo-controlled study. J Clin Pharmacol 1993;33:226-9. PubMed
  4. De Pinieux G, Chariot P, Ammi-Said M, et al. Lipid-lowering drugs and mitochondrial function: Effects of HMG-CoA Reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Br J Clin Pharmacol 1996;42:333-7. PubMed
  5. Bargossi AM, Grossi G, Fiorella PL, et al. Exogenous CoQ10 supplementation prevents plasma ubiquinone reduction induced by HMG-CoA reductase inhibitors. Mol Aspects Med 1994;15:187-93. PubMed
  6. Watts GF, Castelluccio C, Rice-Evans C, et al. Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin. J Clin Pathol 1993;46:1055-7.
  7. Hanaki Y, Sugiyama S, Ozawa T, et al. Coenzyme Q10 and coronary artery disease. Clin Investig 1993;71:112-5. PubMed
  8. Berthold HK, Naini A, Di Mauro S, et al. Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial. Drug Saf 2006;29:703-12. PubMed
  9. Fuke C, Krikorian SA, Couris RR. Coenzyme Q10: A review of essential functions and clinical trials. US Pharm 2000;25:28-41.
  10. Bleske BE, Willis RA, Anthony M, et al. The effect of pravastatin and atorvastatin on coenzyme Q10. Am Heart J 2001;142:E2. PubMed
  11. Rundek T, Naini A, Sacco R, et al. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. Arch Neurol 2004;61:889-92.. PubMed
  12. Laaksonen R, Jokelainen K, Sahi T, et al. Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans. Clin Pharmacol Ther 1995;57:62-6. PubMed

Full nutrient report for Niacin, Simvastatin →

Nicardipine

Insufficient Evidence

Brand names include Cardene, Cardene SR, Cardene IV

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Nicardipine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural substance your body makes that helps your cells produce energy and acts as an antioxidant. Some blood pressure medications, possibly including nicardipine, have been loosely linked to lower CoQ10 levels, though the exact reason for this class of drugs is not well understood. That said, the evidence here is rated insufficient, meaning researchers simply do not yet have enough data to know whether this is a real concern or how meaningful it might be in practice. If you have questions about your levels or whether a supplement makes sense for you, that is a great conversation to have with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Nicardipine →

Nifedipine

Insufficient Evidence

Brand names include Procardia XL, Adalat PA, Adalat

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Nifedipine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Some blood pressure medications have been linked to modest reductions in the body's own CoQ10 levels, possibly by interfering with the enzymes that make or use it, though exactly how nifedipine fits into this picture is not well understood. The evidence here is rated insufficient, meaning researchers simply do not have enough data yet to know whether this matters clinically for people taking nifedipine. For now, most people do not need to act on this, but if you are curious about your CoQ10 status, it is worth bringing up with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Nifedipine →

Nimodipine

Insufficient Evidence

Brand names include Nimotop, Nymalize

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Nimodipine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your body makes naturally that helps cells produce energy and acts as an antioxidant. Some antihypertensive medications have been linked to mildly lower CoQ10 levels, possibly by interfering with the enzymes your body uses to produce it, and nimodipine falls into that general class of blood pressure drugs. That said, the evidence here is truly insufficient, meaning researchers simply do not know yet whether this matters in practice. Most people taking nimodipine do not need to act on this, but if you are curious about your CoQ10 status, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Nimodipine →

Nisoldipine

Insufficient Evidence

Brand names include Sular

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Nisoldipine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Some blood pressure medications have been reported to interfere with the enzymes that make or use coenzyme Q10, which could nudge levels down modestly, though whether nisoldipine specifically does this is not well studied. The evidence here is genuinely thin, so there is no reason to worry or rush out for a supplement. That said, if you are curious about your levels or have questions, your pharmacist or doctor is a great first stop.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Nisoldipine →

Nitroprusside

Insufficient Evidence

Brand names include Nitropress

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Nitroprusside? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. A few antihypertensive medications have been reported to interfere with the enzymes that make or use coenzyme Q10 in the body, and nitroprusside falls into this broader category. That said, the evidence here is genuinely thin, so right now there is no clear reason to worry or to reach for a supplement. If you have questions, your pharmacist or doctor is the right person to weigh in.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Nitroprusside →

Nortriptyline

Insufficient Evidence

Brand names include Pamelor, Aventyl, Allegron

Tricyclic antidepressants can modestly decrease endogenous levels of coenzyme Q10.

Tricyclic antidepressants might inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to tricyclic antidepressant side effects.
Taking Nortriptyline? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. Some research suggests that tricyclic antidepressants like nortriptyline may interfere with the enzymes your body uses to make CoQ10, which could lead to modestly lower levels over time. That said, the evidence here is rated insufficient, meaning scientists simply do not yet know whether this drop is meaningful for most people. If you have been on nortriptyline long-term and are curious, it is worth bringing up with your pharmacist or doctor.

References (1)
  1. Garrido-Maraver J, Cordero MD, Oropesa-Ávila M, et al. Coenzyme Q10 therapy. Mol Syndromol. 2014;5(3-4):187-97.

Full nutrient report for Nortriptyline →

Olmesartan Medoxomil

Insufficient Evidence

Brand names include Benicar

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Olmesartan Medoxomil? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Some antihypertensive medications have been reported to interfere with the enzymes that help your body make its own CoQ10, though exactly how olmesartan fits into that picture is not well understood. The evidence for this particular drug is thin, so most people taking olmesartan do not need to worry about this. If you are curious, it is a perfectly reasonable thing to bring up with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Olmesartan Medoxomil →

Oxprenolol

Insufficient Evidence

Brand names include Slow Trasicor, Trasicor

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Oxprenolol? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to generate energy, and it also acts as an antioxidant. Oxprenolol is a beta blocker, and there is some research suggesting that drugs in this class may interfere with the enzymes your body needs to make coenzyme Q10, potentially nudging levels down a bit. That said, the evidence here is genuinely thin, and it is not known whether any reduction actually matters for your health. If you are curious, it is worth bringing up with your pharmacist or doctor rather than acting on it on your own.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Oxprenolol →

Pargyline

Insufficient Evidence

Brand names include Eutonyl

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Pargyline? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Some blood pressure medications, possibly including pargyline, have been reported to interfere with coenzyme Q10 enzyme activity, which could nudge levels down slightly. That said, the evidence here is really thin, and right now there is no solid proof this reduction causes any noticeable health effects. If you have concerns, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Pargyline →

Penbutolol Sulfate

Insufficient Evidence

Brand names include Levatol

Beta-blockers can decrease endogenous levels of coenzyme Q10.

Beta-blockers are thought to inhibit coenzyme Q10 mitochondrial enzymes and decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to beta-blocker side effects.
Taking Penbutolol Sulfate? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it plays a role in keeping the heart and muscles working well. Penbutolol is a beta-blocker, and there is some research suggesting that drugs in this class may interfere with certain mitochondrial enzymes involved in making coenzyme Q10, potentially lowering the body's own supply. That said, the evidence here is rated insufficient, meaning scientists have not yet established whether this reduction actually causes any real-world problems. If you have concerns, it is worth bringing up with your pharmacist or doctor rather than starting any supplement on your own.

References (1)
  1. Kishi H, Kishi T, Folkers K. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q10 enzymes by clinically used anti-hypertensive drugs. Res Commun Chem Pathol Pharmacol 1975;12:533-40.

Full nutrient report for Penbutolol Sulfate →

Perindopril Arginine, Amlodipine

Insufficient Evidence

Brand names include Prestalia

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Perindopril Arginine, Amlodipine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Some antihypertensive medications have been reported to interfere with the enzymes that help your body make its own CoQ10, which could modestly lower your natural levels over time. That said, the current evidence for this with perindopril and amlodipine is really thin, and nobody has shown that any such drop causes meaningful problems. If you are curious or have concerns, it is worth bringing up with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Perindopril Arginine, Amlodipine →

Perindopril Erbumine

Insufficient Evidence

Brand names include Aceon

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Perindopril Erbumine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a naturally made compound your cells use to produce energy, and it also acts as an antioxidant. There is some early research suggesting that certain blood pressure medications may interfere with the enzymes your body uses to make CoQ10, which could nudge levels down a little. For perindopril specifically, the evidence is quite thin, and researchers have not confirmed this is a real concern with ACE inhibitors like this one. Because the rating here is "insufficient evidence," most people taking perindopril do not need to act on this, but if you are curious whether CoQ10 is relevant for you, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Perindopril Erbumine →

Phenoxybenzamine

Insufficient Evidence

Brand names include Dibenzyline

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Phenoxybenzamine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy and protect tissues from damage. Phenoxybenzamine is an alpha-blocker used to manage blood pressure, and like some other antihypertensive medications, it may interfere with the enzymes your body uses to make coenzyme Q10, potentially nudging levels a little lower. That said, the evidence here is really thin, and no one has clearly shown this translates into any real health problem for patients. If you have been on phenoxybenzamine for a long time and are curious about it, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Phenoxybenzamine →

Pindolol

Insufficient Evidence

Brand names include Visken, Pindol

Beta-blockers can decrease endogenous levels of coenzyme Q10.

Beta-blockers are thought to inhibit coenzyme Q10 mitochondrial enzymes and decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to beta-blocker side effects.
Taking Pindolol? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it plays a role in keeping the heart and muscles running efficiently. Pindolol belongs to the beta-blocker family, and there is some research suggesting these medications may interfere with the enzymes inside cells that help the body make its own coenzyme Q10. That said, the evidence here is genuinely insufficient, meaning scientists have not established that this actually causes problems in people taking pindolol. If you have any concerns, it is worth bringing up with your pharmacist or doctor rather than starting a supplement on your own.

References (1)
  1. Kishi H, Kishi T, Folkers K. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q10 enzymes by clinically used anti-hypertensive drugs. Res Commun Chem Pathol Pharmacol 1975;12:533-40.

Full nutrient report for Pindolol →

Pitavastatin

Insufficient Evidence

Brand names include Zypitamag, Nikita

Statins can halt the synthesis of coenzyme Q10, reducing endogenous levels. However, it is not clear whether this contributes to statin adverse effects, or if coenzyme Q10 supplements reduce these adverse effects.

HMG-CoA reductase inhibitors can reduce serum coenzyme Q10 levels. They block the synthesis of mevalonic acid, which is a precursor of coenzyme Q10, in a dose-dependent manner. Taking atorvastatin 80 mg daily for 30 days reduces coenzyme Q10 serum levels by 52%, but atorvastatin 10 mg daily or pravastatin 20 mg daily do not have this effect in healthy people. In other research, taking simvastatin 20 mg daily for 4 weeks reduces serum coenzyme Q10 levels by about 32%, but muscle levels increase by 47%. Since coenzyme Q10 is transported with low-density lipoprotein (LDL) cholesterol, reduction in LDL cholesterol levels by a statin may increase the amount of free coenzyme Q10 in the blood that is available for uptake into muscles. There is no reliable evidence that statin adverse effects such as myopathy are linked to reduced coenzyme Q10 levels in the blood, or that taking coenzyme Q10 supplements reduces statin side effects.
Taking Pitavastatin? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Pitavastatin works by blocking a liver enzyme called HMG-CoA reductase, and that same pathway the body uses to make cholesterol also happens to produce coenzyme Q10, a compound your cells rely on for energy production. Because the pathway gets interrupted, pitavastatin may nudge CoQ10 levels downward in the blood. That said, the evidence here is genuinely thin, and researchers are still unsure whether this translates into any real health concern for most people taking a statin. If you have questions or are noticing muscle discomfort, it is worth bringing up with your pharmacist or doctor.

References (12)
  1. Folkers K, Langsjoen P, Willis R, et al. Lovastatin decreases coenzyme Q levels in humans. Proc Natl Acad Sci USA 1990;87:8931-4. PubMed
  2. Mortensen SA, Leth A, Agner E, et al. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med 1997;18:S137-44. PubMed
  3. Ghirlanda G, Oradei A, Manto A, et al. Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: A double blind, placebo-controlled study. J Clin Pharmacol 1993;33:226-9. PubMed
  4. De Pinieux G, Chariot P, Ammi-Said M, et al. Lipid-lowering drugs and mitochondrial function: Effects of HMG-CoA Reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Br J Clin Pharmacol 1996;42:333-7. PubMed
  5. Bargossi AM, Grossi G, Fiorella PL, et al. Exogenous CoQ10 supplementation prevents plasma ubiquinone reduction induced by HMG-CoA reductase inhibitors. Mol Aspects Med 1994;15:187-93. PubMed
  6. Watts GF, Castelluccio C, Rice-Evans C, et al. Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin. J Clin Pathol 1993;46:1055-7.
  7. Hanaki Y, Sugiyama S, Ozawa T, et al. Coenzyme Q10 and coronary artery disease. Clin Investig 1993;71:112-5. PubMed
  8. Berthold HK, Naini A, Di Mauro S, et al. Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial. Drug Saf 2006;29:703-12. PubMed
  9. Fuke C, Krikorian SA, Couris RR. Coenzyme Q10: A review of essential functions and clinical trials. US Pharm 2000;25:28-41.
  10. Bleske BE, Willis RA, Anthony M, et al. The effect of pravastatin and atorvastatin on coenzyme Q10. Am Heart J 2001;142:E2. PubMed
  11. Rundek T, Naini A, Sacco R, et al. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. Arch Neurol 2004;61:889-92.. PubMed
  12. Laaksonen R, Jokelainen K, Sahi T, et al. Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans. Clin Pharmacol Ther 1995;57:62-6. PubMed

Full nutrient report for Pitavastatin →

Polythiazide

Insufficient Evidence

Brand names include Renese

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Polythiazide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant in the body. Some antihypertensive medications appear to interfere with the enzymes that make or use coenzyme Q10, which could modestly reduce your natural levels over time. That said, the evidence for polythiazide specifically is quite limited, and nobody has clearly shown this drop causes real health problems. If you are curious, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Polythiazide →

Polythiazide, Prazosin

Insufficient Evidence

Brand names include Minizide

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Polythiazide, Prazosin? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it may also play a role in heart and muscle function. Some blood pressure medications appear to interfere with the enzymes your body uses to make its own coenzyme Q10, which could nudge levels slightly lower over time. For this combination, though, the evidence is genuinely thin, so there is no clear reason for concern right now. If you are curious whether this applies to you, it is worth bringing up with your pharmacist or doctor at your next visit.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Polythiazide, Prazosin →

Polythiazide, Reserpine

Insufficient Evidence

Brand names include Renese R

Thiazides can modestly decrease endogenous levels of coenzyme Q10.

Thiazide diuretics might decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to thiazide c side effects.
Taking Polythiazide, Reserpine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. Some research suggests thiazide diuretics like polythiazide may modestly lower the body's natural coenzyme Q10 levels, possibly by interfering with how the body makes it internally. That said, the evidence here is quite limited, and right now there is no solid proof this translates into any real health problem. If you are curious whether this is worth paying attention to in your case, it is a good question to bring up with your pharmacist or doctor.

References (1)
  1. LaValle JB. Hidden disruptions in metabolic syndrome: drug-induced nutrient depletion as a pathway to accelerated pathophysiology of metabolic syndrome. Altern Ther Health Med. 2006 Mar-Apr;12(2):26-31; quiz 32-3.

Full nutrient report for Polythiazide, Reserpine →

Pravastatin Sodium

Insufficient Evidence

Brand names include Pravachol

Statins can halt the synthesis of coenzyme Q10, reducing endogenous levels. However, it is not clear whether this contributes to statin adverse effects, or if coenzyme Q10 supplements reduce these adverse effects.

HMG-CoA reductase inhibitors can reduce serum coenzyme Q10 levels. They block the synthesis of mevalonic acid, which is a precursor of coenzyme Q10, in a dose-dependent manner. Taking atorvastatin 80 mg daily for 30 days reduces coenzyme Q10 serum levels by 52%, but atorvastatin 10 mg daily or pravastatin 20 mg daily do not have this effect in healthy people. In other research, taking simvastatin 20 mg daily for 4 weeks reduces serum coenzyme Q10 levels by about 32%, but muscle levels increase by 47%. Since coenzyme Q10 is transported with low-density lipoprotein (LDL) cholesterol, reduction in LDL cholesterol levels by a statin may increase the amount of free coenzyme Q10 in the blood that is available for uptake into muscles. There is no reliable evidence that statin adverse effects such as myopathy are linked to reduced coenzyme Q10 levels in the blood, or that taking coenzyme Q10 supplements reduces statin side effects.
Taking Pravastatin Sodium? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and statins like pravastatin work through a pathway that can also reduce your body's ability to make it. That said, research on pravastatin at a typical 20 mg dose has not shown a meaningful drop in blood levels the way higher doses of other statins have. The evidence here is genuinely unclear, so this is not something most people need to worry about on their own. If you have questions, it is always worth a conversation with your pharmacist or doctor.

References (12)
  1. Folkers K, Langsjoen P, Willis R, et al. Lovastatin decreases coenzyme Q levels in humans. Proc Natl Acad Sci USA 1990;87:8931-4. PubMed
  2. Mortensen SA, Leth A, Agner E, et al. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med 1997;18:S137-44. PubMed
  3. Ghirlanda G, Oradei A, Manto A, et al. Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: A double blind, placebo-controlled study. J Clin Pharmacol 1993;33:226-9. PubMed
  4. De Pinieux G, Chariot P, Ammi-Said M, et al. Lipid-lowering drugs and mitochondrial function: Effects of HMG-CoA Reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Br J Clin Pharmacol 1996;42:333-7. PubMed
  5. Bargossi AM, Grossi G, Fiorella PL, et al. Exogenous CoQ10 supplementation prevents plasma ubiquinone reduction induced by HMG-CoA reductase inhibitors. Mol Aspects Med 1994;15:187-93. PubMed
  6. Watts GF, Castelluccio C, Rice-Evans C, et al. Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin. J Clin Pathol 1993;46:1055-7.
  7. Hanaki Y, Sugiyama S, Ozawa T, et al. Coenzyme Q10 and coronary artery disease. Clin Investig 1993;71:112-5. PubMed
  8. Berthold HK, Naini A, Di Mauro S, et al. Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial. Drug Saf 2006;29:703-12. PubMed
  9. Fuke C, Krikorian SA, Couris RR. Coenzyme Q10: A review of essential functions and clinical trials. US Pharm 2000;25:28-41.
  10. Bleske BE, Willis RA, Anthony M, et al. The effect of pravastatin and atorvastatin on coenzyme Q10. Am Heart J 2001;142:E2. PubMed
  11. Rundek T, Naini A, Sacco R, et al. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. Arch Neurol 2004;61:889-92.. PubMed
  12. Laaksonen R, Jokelainen K, Sahi T, et al. Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans. Clin Pharmacol Ther 1995;57:62-6. PubMed

Full nutrient report for Pravastatin Sodium →

Prazosin

Insufficient Evidence

Brand names include Minipress, Prazo, Prazin

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Prazosin? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and your heart muscle in particular depends on healthy levels of it. Some antihypertensive medications appear to interfere with the enzymes that make or activate coenzyme Q10 in the body, and prazosin falls into that broader drug class. That said, the evidence here is really thin, and right now there is no solid proof that this interaction causes any meaningful health effect. If you are curious or have concerns, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Prazosin →

Propranolol

Insufficient Evidence

Brand names include Inderal LA, Inderal, Angilol

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Propranolol? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and your heart muscle in particular depends on it. Propranolol, like other beta blockers, appears to interfere with certain enzymes involved in making or using coenzyme Q10, which could modestly reduce the amount your body has available. That said, the evidence here is really thin, and researchers have not shown that this drop causes any meaningful harm or contributes to side effects. If you are a long-term propranolol user and are curious about your levels, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Propranolol →

Propranolol Hydrochloride

Insufficient Evidence

Brand names include Hemangeol

Beta-blockers can decrease endogenous levels of coenzyme Q10.

Beta-blockers are thought to inhibit coenzyme Q10 mitochondrial enzymes and decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to beta-blocker side effects.
Taking Propranolol Hydrochloride? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it plays a role in keeping the heart and muscles working well. Propranolol belongs to a class called beta-blockers, and research suggests these drugs may interfere with certain enzymes inside cells that are involved in making coenzyme Q10, which can nudge levels down. That said, the evidence here is really thin, and nobody has clearly shown this drop causes any actual symptoms or problems for people taking propranolol. If you have concerns, it is worth bringing up with your pharmacist or doctor rather than starting anything on your own.

References (1)
  1. Kishi H, Kishi T, Folkers K. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q10 enzymes by clinically used anti-hypertensive drugs. Res Commun Chem Pathol Pharmacol 1975;12:533-40.

Full nutrient report for Propranolol Hydrochloride →

Protriptyline

Insufficient Evidence

Brand names include Vivactil

Tricyclic antidepressants can modestly decrease endogenous levels of coenzyme Q10.

Tricyclic antidepressants might inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to tricyclic antidepressant side effects.
Taking Protriptyline? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and some research suggests that tricyclic antidepressants like protriptyline may interfere with how the body makes or uses it. The thinking is that these medications might partially block the activity of enzymes involved in CoQ10 production, though the picture is still fuzzy. Right now the evidence is simply too limited to know whether this matters in practice, and there is no solid proof it causes any symptoms. If you have concerns, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Garrido-Maraver J, Cordero MD, Oropesa-Ávila M, et al. Coenzyme Q10 therapy. Mol Syndromol. 2014;5(3-4):187-97.

Full nutrient report for Protriptyline →

Quinapril

Insufficient Evidence

Brand names include Accupril, Accupro

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Quinapril? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and your heart muscle is especially dependent on it. Some blood pressure medications have been linked to lower CoQ10 levels, possibly by interfering with the enzymes your body uses to make it on its own. For quinapril specifically, the evidence is quite thin, and right now researchers simply do not know whether any reduction is meaningful. If you are curious about your levels or whether a supplement makes sense, that is a good question to bring up with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Quinapril →

Quinethazone

Insufficient Evidence

Brand names include Hydromox

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Quinethazone? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Some antihypertensive medications, possibly including quinethazone, have been reported to interfere with the enzymes that help your body make and use coenzyme Q10, which could modestly lower your internal levels over time. That said, the evidence here is really thin, and no one has clearly shown this matters clinically for people taking this type of drug. If you have questions or concerns, it is worth bringing up with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Quinethazone →

Quinethazone, Reserpine

Insufficient Evidence

Brand names include Hydromox R

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Quinethazone, Reserpine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Some antihypertensive medications, possibly including this combination, have been reported to interfere with the enzymes that make or use CoQ10 in the body, which could nudge levels slightly lower over time. That said, the evidence here is genuinely insufficient, meaning researchers simply do not yet know whether this matters clinically for most people taking these drugs. No action is needed right now, but if you have questions or concerns, a quick conversation with your pharmacist or doctor is always a reasonable step.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Quinethazone, Reserpine →

Ramipril

Insufficient Evidence

Brand names include Altace

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Ramipril? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a substance your body makes naturally that helps cells produce energy and acts as an antioxidant. Some antihypertensive medications have been reported to interfere with the enzymes that keep CoQ10 levels up, though it is not well established whether ramipril specifically does this or whether any small drop actually causes problems. The evidence here is genuinely thin, so this is not something most people on ramipril need to worry about right now. If you are curious or have concerns, it is worth bringing up with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Ramipril →

Rescinnamine

Insufficient Evidence

Brand names include Moderil

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Rescinnamine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and your heart muscle relies on it heavily. Some blood pressure medications appear to interfere with the enzymes that make or activate coenzyme Q10 in the body, and rescinnamine belongs to that general class of antihypertensives, so a similar effect is plausible. That said, the evidence here is truly insufficient, meaning researchers simply do not yet know whether any drop in levels is meaningful. Most people taking rescinnamine do not need to act on this, but if you have questions or notice unusual fatigue, it is worth a conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Rescinnamine →

Reserpine

Insufficient Evidence

Brand names include Serpasil, Sandril

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Reserpine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and your heart muscle in particular depends on it. Some blood pressure medications appear to interfere with enzymes that help the body make its own CoQ10, and reserpine falls into that broader antihypertensive category. That said, the evidence here is genuinely thin, so this is listed as insufficient rather than a well-documented concern. Most people on reserpine do not need to act on this, but if you are curious whether CoQ10 monitoring or supplementation makes sense for you, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Reserpine →

Reserpine, Trichlormethiazide

Insufficient Evidence

Brand names include Naquival, Metatensin #2, Metatensin #4

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Reserpine, Trichlormethiazide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. The thiazide diuretic component of this combination (trichlormethiazide) has been reported to modestly reduce the body's own coenzyme Q10 levels, though researchers aren't sure exactly how. What's important to know is that the evidence here is quite thin, and there's no clear proof this reduction causes any real health problem. If you're curious whether monitoring or supplementation makes sense for you, it's worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Reserpine, Trichlormethiazide →

Riociguat

Insufficient Evidence

Brand names include Adempas

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Riociguat? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your body makes that helps cells produce energy and acts as an antioxidant. Some blood pressure-lowering medications appear to interfere with the enzymes your body uses to produce CoQ10, and riociguat, which works to lower blood pressure in the lungs and body, may fall into that category. Right now the evidence is too thin to know whether this matters in a real-world way for people taking riociguat. If you have concerns, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Riociguat →

Rosuvastatin

Insufficient Evidence

Brand names include Crestor, Ezallor

Statins can halt the synthesis of coenzyme Q10, reducing endogenous levels. However, it is not clear whether this contributes to statin adverse effects, or if coenzyme Q10 supplements reduce these adverse effects.

HMG-CoA reductase inhibitors can reduce serum coenzyme Q10 levels. They block the synthesis of mevalonic acid, which is a precursor of coenzyme Q10, in a dose-dependent manner. Taking atorvastatin 80 mg daily for 30 days reduces coenzyme Q10 serum levels by 52%, but atorvastatin 10 mg daily or pravastatin 20 mg daily do not have this effect in healthy people. In other research, taking simvastatin 20 mg daily for 4 weeks reduces serum coenzyme Q10 levels by about 32%, but muscle levels increase by 47%. Since coenzyme Q10 is transported with low-density lipoprotein (LDL) cholesterol, reduction in LDL cholesterol levels by a statin may increase the amount of free coenzyme Q10 in the blood that is available for uptake into muscles. There is no reliable evidence that statin adverse effects such as myopathy are linked to reduced coenzyme Q10 levels in the blood, or that taking coenzyme Q10 supplements reduces statin side effects.
Taking Rosuvastatin? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Rosuvastatin works by blocking a liver pathway called HMG-CoA reductase, and that same pathway happens to be involved in making coenzyme Q10, a compound your cells use to produce energy. So rosuvastatin can reduce your body's own CoQ10 production, at least in the bloodstream. That said, the evidence here is rated insufficient, meaning researchers simply do not yet know whether this drop matters for your health or causes any symptoms. If you are curious about whether CoQ10 is something worth discussing for your situation, bring it up with your pharmacist or doctor.

References (12)
  1. Folkers K, Langsjoen P, Willis R, et al. Lovastatin decreases coenzyme Q levels in humans. Proc Natl Acad Sci USA 1990;87:8931-4. PubMed
  2. Mortensen SA, Leth A, Agner E, et al. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med 1997;18:S137-44. PubMed
  3. Ghirlanda G, Oradei A, Manto A, et al. Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: A double blind, placebo-controlled study. J Clin Pharmacol 1993;33:226-9. PubMed
  4. De Pinieux G, Chariot P, Ammi-Said M, et al. Lipid-lowering drugs and mitochondrial function: Effects of HMG-CoA Reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Br J Clin Pharmacol 1996;42:333-7. PubMed
  5. Bargossi AM, Grossi G, Fiorella PL, et al. Exogenous CoQ10 supplementation prevents plasma ubiquinone reduction induced by HMG-CoA reductase inhibitors. Mol Aspects Med 1994;15:187-93. PubMed
  6. Watts GF, Castelluccio C, Rice-Evans C, et al. Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin. J Clin Pathol 1993;46:1055-7.
  7. Hanaki Y, Sugiyama S, Ozawa T, et al. Coenzyme Q10 and coronary artery disease. Clin Investig 1993;71:112-5. PubMed
  8. Berthold HK, Naini A, Di Mauro S, et al. Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial. Drug Saf 2006;29:703-12. PubMed
  9. Fuke C, Krikorian SA, Couris RR. Coenzyme Q10: A review of essential functions and clinical trials. US Pharm 2000;25:28-41.
  10. Bleske BE, Willis RA, Anthony M, et al. The effect of pravastatin and atorvastatin on coenzyme Q10. Am Heart J 2001;142:E2. PubMed
  11. Rundek T, Naini A, Sacco R, et al. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. Arch Neurol 2004;61:889-92.. PubMed
  12. Laaksonen R, Jokelainen K, Sahi T, et al. Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans. Clin Pharmacol Ther 1995;57:62-6. PubMed

Full nutrient report for Rosuvastatin →

Rosuvastatin Calcium, Ezetimibe

Insufficient Evidence

Brand names include Roszet

Statins can halt the synthesis of coenzyme Q10, reducing endogenous levels. However, it is not clear whether this contributes to statin adverse effects, or if coenzyme Q10 supplements reduce these adverse effects.

HMG-CoA reductase inhibitors can reduce serum coenzyme Q10 levels. They block the synthesis of mevalonic acid, which is a precursor of coenzyme Q10, in a dose-dependent manner. Taking atorvastatin 80 mg daily for 30 days reduces coenzyme Q10 serum levels by 52%, but atorvastatin 10 mg daily or pravastatin 20 mg daily do not have this effect in healthy people. In other research, taking simvastatin 20 mg daily for 4 weeks reduces serum coenzyme Q10 levels by about 32%, but muscle levels increase by 47%. Since coenzyme Q10 is transported with low-density lipoprotein (LDL) cholesterol, reduction in LDL cholesterol levels by a statin may increase the amount of free coenzyme Q10 in the blood that is available for uptake into muscles. There is no reliable evidence that statin adverse effects such as myopathy are linked to reduced coenzyme Q10 levels in the blood, or that taking coenzyme Q10 supplements reduces statin side effects.
Taking Rosuvastatin Calcium, Ezetimibe? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. The statin in this combination (rosuvastatin) works by blocking a liver pathway called the mevalonate pathway, and that same pathway happens to be a stepping stone for the body's own CoQ10 production, so statin use can be associated with lower CoQ10 levels in the blood. That said, the evidence here is rated insufficient, meaning researchers simply do not yet know whether this translates into any real health consequence or whether taking a CoQ10 supplement would help. If you have questions or are experiencing muscle discomfort while on this medication, it is worth bringing up with your pharmacist or doctor.

References (12)
  1. Folkers K, Langsjoen P, Willis R, et al. Lovastatin decreases coenzyme Q levels in humans. Proc Natl Acad Sci USA 1990;87:8931-4. PubMed
  2. Mortensen SA, Leth A, Agner E, et al. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med 1997;18:S137-44. PubMed
  3. Ghirlanda G, Oradei A, Manto A, et al. Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: A double blind, placebo-controlled study. J Clin Pharmacol 1993;33:226-9. PubMed
  4. De Pinieux G, Chariot P, Ammi-Said M, et al. Lipid-lowering drugs and mitochondrial function: Effects of HMG-CoA Reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Br J Clin Pharmacol 1996;42:333-7. PubMed
  5. Bargossi AM, Grossi G, Fiorella PL, et al. Exogenous CoQ10 supplementation prevents plasma ubiquinone reduction induced by HMG-CoA reductase inhibitors. Mol Aspects Med 1994;15:187-93. PubMed
  6. Watts GF, Castelluccio C, Rice-Evans C, et al. Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin. J Clin Pathol 1993;46:1055-7.
  7. Hanaki Y, Sugiyama S, Ozawa T, et al. Coenzyme Q10 and coronary artery disease. Clin Investig 1993;71:112-5. PubMed
  8. Berthold HK, Naini A, Di Mauro S, et al. Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial. Drug Saf 2006;29:703-12. PubMed
  9. Fuke C, Krikorian SA, Couris RR. Coenzyme Q10: A review of essential functions and clinical trials. US Pharm 2000;25:28-41.
  10. Bleske BE, Willis RA, Anthony M, et al. The effect of pravastatin and atorvastatin on coenzyme Q10. Am Heart J 2001;142:E2. PubMed
  11. Rundek T, Naini A, Sacco R, et al. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. Arch Neurol 2004;61:889-92.. PubMed
  12. Laaksonen R, Jokelainen K, Sahi T, et al. Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans. Clin Pharmacol Ther 1995;57:62-6. PubMed

Full nutrient report for Rosuvastatin Calcium, Ezetimibe →

Sacubitril, Valsartan

Insufficient Evidence

Brand names include Entresto

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Sacubitril, Valsartan? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Some blood pressure medications have been linked to modest reductions in the body's natural CoQ10 levels, possibly by interfering with the enzymes that make it, and sacubitril/valsartan falls into that general category. That said, the evidence here is genuinely thin, and right now there is no solid proof this matters clinically for most people taking this medication. If you are curious whether any monitoring or dietary consideration makes sense for you, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Sacubitril, Valsartan →

Selexipag

Insufficient Evidence

Brand names include Uptravi

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Selexipag? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and your heart muscle relies on it quite a bit. Selexipag is used for pulmonary arterial hypertension rather than general high blood pressure, so its connection to coenzyme Q10 is even less clear than it is for classic antihypertensive drugs. The current evidence is simply too thin to know whether selexipag meaningfully affects coenzyme Q10 levels at all. If you have concerns, it is worth bringing up with your pharmacist or doctor, but there is no solid reason to worry about this right now.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Selexipag →

Simvastatin

Insufficient Evidence

Brand names include Zocor

Statins can halt the synthesis of coenzyme Q10, reducing endogenous levels. However, it is not clear whether this contributes to statin adverse effects, or if coenzyme Q10 supplements reduce these adverse effects.

HMG-CoA reductase inhibitors can reduce serum coenzyme Q10 levels. They block the synthesis of mevalonic acid, which is a precursor of coenzyme Q10, in a dose-dependent manner. Taking atorvastatin 80 mg daily for 30 days reduces coenzyme Q10 serum levels by 52%, but atorvastatin 10 mg daily or pravastatin 20 mg daily do not have this effect in healthy people. In other research, taking simvastatin 20 mg daily for 4 weeks reduces serum coenzyme Q10 levels by about 32%, but muscle levels increase by 47%. Since coenzyme Q10 is transported with low-density lipoprotein (LDL) cholesterol, reduction in LDL cholesterol levels by a statin may increase the amount of free coenzyme Q10 in the blood that is available for uptake into muscles. There is no reliable evidence that statin adverse effects such as myopathy are linked to reduced coenzyme Q10 levels in the blood, or that taking coenzyme Q10 supplements reduces statin side effects.
Taking Simvastatin? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and simvastatin may reduce the amount your body makes on its own. Here is why: simvastatin works by blocking a step in a biochemical pathway, and coenzyme Q10 happens to be made through that same pathway, so production can drop as a side effect. That said, the evidence here is rated insufficient, meaning researchers are genuinely unsure whether lower blood levels actually cause harm or whether taking a supplement helps. If you have questions or are noticing muscle discomfort while on simvastatin, it is worth bringing up with your pharmacist or doctor.

References (12)
  1. Folkers K, Langsjoen P, Willis R, et al. Lovastatin decreases coenzyme Q levels in humans. Proc Natl Acad Sci USA 1990;87:8931-4. PubMed
  2. Mortensen SA, Leth A, Agner E, et al. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med 1997;18:S137-44. PubMed
  3. Ghirlanda G, Oradei A, Manto A, et al. Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: A double blind, placebo-controlled study. J Clin Pharmacol 1993;33:226-9. PubMed
  4. De Pinieux G, Chariot P, Ammi-Said M, et al. Lipid-lowering drugs and mitochondrial function: Effects of HMG-CoA Reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Br J Clin Pharmacol 1996;42:333-7. PubMed
  5. Bargossi AM, Grossi G, Fiorella PL, et al. Exogenous CoQ10 supplementation prevents plasma ubiquinone reduction induced by HMG-CoA reductase inhibitors. Mol Aspects Med 1994;15:187-93. PubMed
  6. Watts GF, Castelluccio C, Rice-Evans C, et al. Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin. J Clin Pathol 1993;46:1055-7.
  7. Hanaki Y, Sugiyama S, Ozawa T, et al. Coenzyme Q10 and coronary artery disease. Clin Investig 1993;71:112-5. PubMed
  8. Berthold HK, Naini A, Di Mauro S, et al. Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial. Drug Saf 2006;29:703-12. PubMed
  9. Fuke C, Krikorian SA, Couris RR. Coenzyme Q10: A review of essential functions and clinical trials. US Pharm 2000;25:28-41.
  10. Bleske BE, Willis RA, Anthony M, et al. The effect of pravastatin and atorvastatin on coenzyme Q10. Am Heart J 2001;142:E2. PubMed
  11. Rundek T, Naini A, Sacco R, et al. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. Arch Neurol 2004;61:889-92.. PubMed
  12. Laaksonen R, Jokelainen K, Sahi T, et al. Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans. Clin Pharmacol Ther 1995;57:62-6. PubMed

Full nutrient report for Simvastatin →

simvastatin/ezetimibe

Insufficient Evidence

Brand names include Vytorin

Statins can halt the synthesis of coenzyme Q10, reducing endogenous levels. However, it is not clear whether this contributes to statin adverse effects, or if coenzyme Q10 supplements reduce these adverse effects.

HMG-CoA reductase inhibitors can reduce serum coenzyme Q10 levels. They block the synthesis of mevalonic acid, which is a precursor of coenzyme Q10, in a dose-dependent manner. Taking atorvastatin 80 mg daily for 30 days reduces coenzyme Q10 serum levels by 52%, but atorvastatin 10 mg daily or pravastatin 20 mg daily do not have this effect in healthy people. In other research, taking simvastatin 20 mg daily for 4 weeks reduces serum coenzyme Q10 levels by about 32%, but muscle levels increase by 47%. Since coenzyme Q10 is transported with low-density lipoprotein (LDL) cholesterol, reduction in LDL cholesterol levels by a statin may increase the amount of free coenzyme Q10 in the blood that is available for uptake into muscles. There is no reliable evidence that statin adverse effects such as myopathy are linked to reduced coenzyme Q10 levels in the blood, or that taking coenzyme Q10 supplements reduces statin side effects.
Taking simvastatin/ezetimibe? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it happens to share a production pathway with cholesterol. Because simvastatin works by blocking an early step in that pathway, it can also reduce how much coenzyme Q10 your body makes on its own. Here is the twist though: some research suggests that even when blood levels dip, muscle levels may actually rise, possibly because less LDL is carrying the compound away. Right now the evidence is genuinely uncertain, so most people on this combination do not need to act on this, but if you are curious about whether it matters for you personally, it is worth a conversation with your pharmacist or doctor.

References (12)
  1. Folkers K, Langsjoen P, Willis R, et al. Lovastatin decreases coenzyme Q levels in humans. Proc Natl Acad Sci USA 1990;87:8931-4. PubMed
  2. Mortensen SA, Leth A, Agner E, et al. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med 1997;18:S137-44. PubMed
  3. Ghirlanda G, Oradei A, Manto A, et al. Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: A double blind, placebo-controlled study. J Clin Pharmacol 1993;33:226-9. PubMed
  4. De Pinieux G, Chariot P, Ammi-Said M, et al. Lipid-lowering drugs and mitochondrial function: Effects of HMG-CoA Reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Br J Clin Pharmacol 1996;42:333-7. PubMed
  5. Bargossi AM, Grossi G, Fiorella PL, et al. Exogenous CoQ10 supplementation prevents plasma ubiquinone reduction induced by HMG-CoA reductase inhibitors. Mol Aspects Med 1994;15:187-93. PubMed
  6. Watts GF, Castelluccio C, Rice-Evans C, et al. Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin. J Clin Pathol 1993;46:1055-7.
  7. Hanaki Y, Sugiyama S, Ozawa T, et al. Coenzyme Q10 and coronary artery disease. Clin Investig 1993;71:112-5. PubMed
  8. Berthold HK, Naini A, Di Mauro S, et al. Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial. Drug Saf 2006;29:703-12. PubMed
  9. Fuke C, Krikorian SA, Couris RR. Coenzyme Q10: A review of essential functions and clinical trials. US Pharm 2000;25:28-41.
  10. Bleske BE, Willis RA, Anthony M, et al. The effect of pravastatin and atorvastatin on coenzyme Q10. Am Heart J 2001;142:E2. PubMed
  11. Rundek T, Naini A, Sacco R, et al. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. Arch Neurol 2004;61:889-92.. PubMed
  12. Laaksonen R, Jokelainen K, Sahi T, et al. Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans. Clin Pharmacol Ther 1995;57:62-6. PubMed

Full nutrient report for simvastatin/ezetimibe →

Sitaxsentan sodium

Insufficient Evidence

Brand names include Thelin

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Sitaxsentan sodium? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Some antihypertensive medications have been reported to interfere with the enzymes that make or use CoQ10, and sitaxsentan sodium falls into this broader category, though the specific details for this drug are not well studied. Right now the evidence is truly insufficient to know whether this matters in practice, so most people taking sitaxsentan do not need to worry about it. That said, if you have questions or want to discuss whether any monitoring makes sense for you, your pharmacist or doctor is the right person to ask.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Sitaxsentan sodium →

Sodium Nitroprusside

Insufficient Evidence

Brand names include Nipride RTU

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Sodium Nitroprusside? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy and protect tissues from damage. Some antihypertensive medicines, possibly including sodium nitroprusside, may interfere with the enzymes that keep coenzyme Q10 levels where they should be, though exactly how this plays out with this particular drug is not well understood. The evidence here is genuinely preliminary, so there is no reason to worry or make any changes on your own. If you are curious whether this is worth tracking in your situation, a quick conversation with your pharmacist or doctor is the right place to start.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Sodium Nitroprusside →

Sotalol

Insufficient Evidence

Brand names include Betapace AF, Betapace, Sotacor

Beta-blockers can decrease endogenous levels of coenzyme Q10.

Beta-blockers are thought to inhibit coenzyme Q10 mitochondrial enzymes and decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to beta-blocker side effects.
Taking Sotalol? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to generate energy, and it plays a role in keeping the heart and muscles working efficiently. Sotalol is a beta-blocker, and there is some research suggesting that drugs in this class may interfere with the cellular machinery that produces coenzyme Q10, potentially nudging levels down over time. That said, the evidence here is genuinely thin, and it is not known whether this drop is large enough to actually matter for most people taking sotalol. If you have been on this medication long-term and are curious, it is worth bringing up with your pharmacist or doctor.

References (1)
  1. Kishi H, Kishi T, Folkers K. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q10 enzymes by clinically used anti-hypertensive drugs. Res Commun Chem Pathol Pharmacol 1975;12:533-40.

Full nutrient report for Sotalol →

Sotalol Hydrochloride

Insufficient Evidence

Brand names include Sotylize

Beta-blockers can decrease endogenous levels of coenzyme Q10.

Beta-blockers are thought to inhibit coenzyme Q10 mitochondrial enzymes and decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to beta-blocker side effects.
Taking Sotalol Hydrochloride? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it plays a role in keeping the heart muscle working efficiently. Sotalol is a beta-blocker, and there is some research suggesting that beta-blockers as a class may interfere with certain enzymes inside the mitochondria that the body needs to make its own coenzyme Q10, which could nudge levels lower over time. That said, the evidence here is rated insufficient, meaning researchers have not confirmed this is actually a problem in people taking sotalol. For now, most people do not need to act on this, but if you have questions or take sotalol long-term, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi H, Kishi T, Folkers K. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q10 enzymes by clinically used anti-hypertensive drugs. Res Commun Chem Pathol Pharmacol 1975;12:533-40.

Full nutrient report for Sotalol Hydrochloride →

Spironolactone

Insufficient Evidence

Brand names include Aldactone, Spiroton, Carospir

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Spironolactone? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your body makes and uses to produce energy inside cells, and it also acts as an antioxidant. Some blood pressure medications have been linked to mildly reduced CoQ10 levels, possibly by interfering with the enzymes your body uses to make it, and spironolactone falls loosely into that category. That said, the evidence here is genuinely thin, so this is rated as insufficient, meaning no one really knows yet whether the dip matters in practice. If you are curious or have concerns, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Spironolactone →

Talinolol

Insufficient Evidence
Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Talinolol? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Talinolol is a beta blocker, and there is some evidence that drugs in this class may interfere with the enzymes your body uses to make coenzyme Q10, potentially nudging levels a bit lower. That said, the evidence here is rated as insufficient, meaning researchers simply do not yet know whether this drop matters in practice. If you have been on talinolol long-term and are curious, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Talinolol →

Telmisartan

Insufficient Evidence

Brand names include Micardis

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Telmisartan? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and the heart relies on it quite a bit. Some antihypertensive drugs have been reported to interfere with enzymes that the body uses to make CoQ10, which could nudge levels down a little. For telmisartan specifically, the honest answer is that we just don't have enough reliable evidence to know whether this matters clinically. Most people taking telmisartan don't need to act on this, but if you're curious about your CoQ10 levels, it's worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Telmisartan →

Telmisartan, Amlodipine

Insufficient Evidence

Brand names include Twynsta

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Telmisartan, Amlodipine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Some antihypertensive medications have been reported to interfere with the enzymes that help your body make or use CoQ10, which could modestly lower its levels over time. That said, the evidence for telmisartan and amlodipine specifically is insufficient, meaning we simply do not have enough reliable data to know whether this is a real concern in practice. If you are a long-term user and curious, it is worth bringing up with your pharmacist or doctor rather than starting a supplement on your own.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Telmisartan, Amlodipine →

Terazosin

Insufficient Evidence

Brand names include Hytrin

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Terazosin? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your body makes that helps cells produce energy and acts as an antioxidant. Some blood pressure medications have been reported to interfere with the enzymes that the body uses to produce coenzyme Q10, and terazosin falls into this general category, though the research specific to terazosin is very thin. Right now there simply is not enough evidence to know whether this matters in practice for most people taking terazosin. If you are curious, it is worth bringing up with your pharmacist or doctor rather than starting a supplement on your own.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Terazosin →

Timolol

Insufficient Evidence

Brand names include Blocadren, Timol, Timoptic

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Timolol? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and the heart muscle relies on it heavily. Timolol is a beta blocker, and some research suggests beta blockers may interfere with the enzymes your body uses to make coenzyme Q10, which could nudge levels down modestly. That said, the evidence here is genuinely thin, and no one has clearly shown this matters for most people taking timolol. If you are curious, it is worth bringing up with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Timolol →

Torsemide

Insufficient Evidence

Brand names include Demadex, Soaanz

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Torsemide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Some antihypertensive medications have been reported to interfere with the enzymes that make or use CoQ10, which could nudge levels down a bit, though torsemide is a loop diuretic rather than the beta blockers or vasodilators most often linked to this effect. The evidence here is rated insufficient, meaning researchers simply have not studied this enough to know whether it matters practically. Most people taking torsemide do not need to act on this, but if you are curious or have concerns, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Torsemide →

Trandolapril

Insufficient Evidence

Brand names include Mavik

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Trandolapril? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and your heart muscle in particular depends on it. Some blood pressure medications have been reported to interfere with enzymes the body uses to make or activate coenzyme Q10, and trandolapril belongs to that general class of antihypertensives, so a mild effect is plausible. That said, the evidence here is truly insufficient, meaning researchers have not yet confirmed this is a real or meaningful concern with trandolapril specifically. If you are curious whether monitoring or a supplement makes sense for you, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Trandolapril →

Trandolapril, Verapamil

Insufficient Evidence

Brand names include Tarka

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Trandolapril, Verapamil? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your body makes that helps cells produce energy and acts as an antioxidant. Some blood pressure medications, including verapamil, appear to interfere with certain enzymes involved in the body's own CoQ10 production, which could modestly reduce levels over time. That said, the evidence here is really thin, and no one has shown this causes actual problems for people taking these medications. If you are curious or have concerns, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Trandolapril, Verapamil →

Treprostinil (Inh)

Insufficient Evidence

Brand names include Tyvaso

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Treprostinil (Inh)? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and your heart muscle in particular depends on it. Treprostinil is a pulmonary vasodilator, not a classic antihypertensive, so any connection to CoQ10 levels is based on a loose class effect seen with some blood pressure drugs rather than solid evidence for this specific medication. Honestly, the evidence here is too thin to draw firm conclusions. If you are curious or have concerns, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Treprostinil (Inh) →

Treprostinil (Oral)

Insufficient Evidence

Brand names include Remodulin, Orenitram

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Treprostinil (Oral)? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Treprostinil is a blood vessel-relaxing medication, and some drugs in that broader category have been reported to interfere with enzymes that your body needs to make coenzyme Q10, potentially nudging levels down over time. That said, the evidence here is really thin, and right now it is not known whether this interaction is meaningful for patients. If you have questions or are curious about monitoring, your pharmacist or doctor is the right person to ask.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Treprostinil (Oral) →

Triamterene

Insufficient Evidence

Brand names include Dyrenium

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Triamterene? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. Some blood pressure medications have been reported to interfere with enzymes involved in the body's own CoQ10 production, which could modestly lower its levels, though whether triamterene specifically does this is not well studied. The evidence here is simply too thin to draw firm conclusions, so most people taking triamterene do not need to worry about this. If you have questions or take triamterene long-term, it is worth bringing up with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Triamterene →

Trichlormethiazide

Insufficient Evidence

Brand names include Metahydrin, Naqua, Marazide II

Thiazides can modestly decrease endogenous levels of coenzyme Q10.

Thiazide diuretics might decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to thiazide c side effects.
Taking Trichlormethiazide? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Trichlormethiazide is a thiazide diuretic, and this class of water pills has been loosely linked to modest dips in the body's own CoQ10 levels, though exactly how that happens is not fully worked out. The evidence here is rated insufficient, meaning researchers simply do not yet have enough data to know whether this matters in a real, day-to-day way for patients. If you are curious or have concerns, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. LaValle JB. Hidden disruptions in metabolic syndrome: drug-induced nutrient depletion as a pathway to accelerated pathophysiology of metabolic syndrome. Altern Ther Health Med. 2006 Mar-Apr;12(2):26-31; quiz 32-3.

Full nutrient report for Trichlormethiazide →

Trimethaphan

Insufficient Evidence

Brand names include Arfonad

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Trimethaphan? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant. Some antihypertensive drugs, possibly including trimethaphan, may interfere with the enzymes your body uses to make coenzyme Q10, which could modestly lower your natural levels. That said, the evidence here is really thin, and right now there is no solid proof this matters clinically. If you are curious whether any monitoring or supplementation makes sense for you, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Trimethaphan →

Trimipramine

Insufficient Evidence

Brand names include Surmontil, Trimip, Rhotrimine

Tricyclic antidepressants can modestly decrease endogenous levels of coenzyme Q10.

Tricyclic antidepressants might inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to tricyclic antidepressant side effects.
Taking Trimipramine? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your body makes that helps cells produce energy and acts as an antioxidant. Some research suggests tricyclic antidepressants like trimipramine may interfere with how coenzyme Q10 works at the cellular level, possibly leading to modest reductions in the body's own supply. That said, the evidence here is really thin, and it is not known whether this has any practical effect on how you feel. If you have questions or concerns, a quick conversation with your pharmacist or doctor is the right move.

References (1)
  1. Garrido-Maraver J, Cordero MD, Oropesa-Ávila M, et al. Coenzyme Q10 therapy. Mol Syndromol. 2014;5(3-4):187-97.

Full nutrient report for Trimipramine →

Urea

Insufficient Evidence

Brand names include Ureaphil

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Urea? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a compound your cells use to produce energy, and your heart muscle relies on it heavily. Urea itself is a topical skin treatment, but the record here seems to be referencing a broader class of antihypertensive drugs, and the evidence that any of them meaningfully reduce coenzyme Q10 levels is thin and not well established. The current rating is 'insufficient evidence,' meaning researchers simply do not have enough data to say whether this is a real concern in practice. Most people using urea do not need to worry about this, but if you have questions about coenzyme Q10 and any blood pressure medications you take, it is worth a conversation with your pharmacist or doctor.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Urea →

Valsartan

Insufficient Evidence

Brand names include Diovan, Prexxartan

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Valsartan? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and your heart muscle relies on it heavily. Some blood pressure medications have been linked to modest reductions in the body's own CoQ10 levels, possibly by interfering with certain enzymes involved in making or using it, though valsartan specifically has not been well studied for this effect. Right now the evidence is simply too limited to know whether this matters in real life, and there is no solid proof it causes side effects. If you are curious or concerned, it is worth a quick conversation with your pharmacist or doctor before considering anything further.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Valsartan →

Verapamil

Insufficient Evidence

Brand names include Isoptin SR, Verelan, Isoptin

Some antihypertensive drugs can modestly decrease endogenous levels of coenzyme Q10.

Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Taking Verapamil? Insufficient evidence to rate; clinical significance is not known.
Dr. Brian Staiger, Pharm.D explains

Coenzyme Q10 is a natural compound your cells use to produce energy, and it also acts as an antioxidant. Some antihypertensive medications appear to interfere with the enzymes that help your body make or use CoQ10, and verapamil falls into this broader class of blood pressure drugs where that concern has been raised. That said, the evidence here is really thin, and right now there is no solid proof this matters clinically for people taking verapamil. If you are curious or have concerns, it is worth a quick conversation with your pharmacist or doctor before considering any supplement.

References (1)
  1. Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.

Full nutrient report for Verapamil →

Important

This tool is educational and is not a substitute for professional medical advice. An association is not a diagnosis and does not mean a deficiency will occur. Always talk to your pharmacist or healthcare provider before starting, stopping, or changing any medication or supplement.

Disclaimer: This checker finds which nutrients might be depleted by prescription or over-the-counter medications. Each nutrient depletion issue is rated based on clinical significance. Use your own professional judgment prior to making clinical decisions.

© 2026 Therapeutic Research Center Licensed records refresh weekly · last updated July 3, 2026.
Understand the basics

What drug-induced nutrient depletion means

Some medications can, over time, lower the levels of certain vitamins, minerals, or other nutrients — through reduced absorption, increased loss, or changes in how the body uses them.

Association is not deficiency

An entry here means a depletion has been reported or studied — not that it happens to everyone, or that you are deficient. Dose, duration, diet, and your own health all matter.

Evidence varies by pair

Some drug–nutrient links (like metformin and vitamin B12) are well studied; others rest on limited or preliminary research. Each entry shows the evidence rating from our licensed clinical database.

When to ask about labs

If you take an associated medication long-term, ask your healthcare provider whether monitoring is appropriate for you. Not everyone needs testing — your provider can weigh your dose, duration, and symptoms.

Don't self-supplement blindly

Supplements are not risk-free: some can interact with medications, and some (like potassium or magnesium) can be risky with kidney disease. Talk to your pharmacist before adding anything.

Never stop a medication over this

These medications are prescribed for good reasons, and the benefit usually far outweighs a manageable nutrient consideration. Any change belongs in a conversation with your prescriber.

Food first, usually

For many nutrients, a varied diet covers the gap. Each entry lists common food sources; a supplement is a decision to make with your pharmacist or provider, not a default.

Common questions

COENZYME Q10 & medications: FAQs

Which medications can lower COENZYME Q10?
In our licensed clinical database, 288 medications have been associated with COENZYME Q10 depletion, including Acarbose, Acetohexamide, Albiglutide and Alogliptin. Each entry above shows the evidence rating and the published details. An association is not a guarantee — dose, duration, diet, and your own health all matter.
I take one of these medications — am I deficient in COENZYME Q10?
Not necessarily. These entries describe reported associations, not certainties. Many people take these medications without developing a meaningful COENZYME Q10 problem. If you take one long-term, the reasonable step is to ask your healthcare provider whether checking your COENZYME Q10 status is appropriate for you.
Should I start a COENZYME Q10 supplement?
Not without checking first. Supplements are not risk-free — some interact with medications, and for certain nutrients (like potassium or magnesium) supplementation can be genuinely risky with kidney disease or particular drug combinations. Food-first strategies and clinician-guided testing usually come before a supplement.
Where does this information come from?
The depletion records come from the Natural Medicines (Therapeutic Research Center) database — an evidence-graded clinical reference — and are displayed as published, with their citations. The plain-English education is written and reviewed by licensed HelloPharmacist pharmacists.

Wondering about your COENZYME Q10 levels?

Ask a licensed pharmacist — free, no appointment needed.

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Sources

Sources & How We Checked

Medication associations with COENZYME Q10 are evidence-graded and sourced from the Natural Medicines database, and are displayed as published with their citations.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.