Perindopril Arginine, Amlodipine & Nutrient Depletion
Also searched as Prestalia. What the clinical evidence reports, what it may mean, and what to discuss with your pharmacist.
Perindopril Arginine, Amlodipine has been associated with depletion of COENZYME Q10 and VITAMIN C. This does not mean a deficiency will occur — it means these are worth knowing about and, if you take Perindopril Arginine, Amlodipine long-term, worth raising with your pharmacist or healthcare provider.
Take more than one medication? Open the checker with Perindopril Arginine, Amlodipine pre-loaded and add the rest to see overlapping nutrient signals.
Reported nutrient depletions with Perindopril Arginine, Amlodipine
Each record below is shown as published in our licensed clinical database, with its evidence rating and citations. Expand a section for food sources and talking points.
COENZYME Q10
Insufficient EvidenceANTIHYPERTENSIVE DRUGS
Some antihypertensive drugs, including beta blockers, diazoxide, hydralazine, and others, appear to inhibit coenzyme Q10 enzyme activity and may decrease endogenous levels of coenzyme Q10. However, it is not clear if this reduction is clinically significant. There is no reliable evidence that coenzyme Q10 depletion contributes to antihypertensive drug side effects.
Coenzyme Q10 is a compound your cells use to produce energy, and it also acts as an antioxidant throughout the body. Some antihypertensive medications have been reported to interfere with the enzymes that help your body make its own CoQ10, which could modestly lower your natural levels over time. That said, the current evidence for this with perindopril and amlodipine is really thin, and nobody has shown that any such drop causes meaningful problems. If you are curious or have concerns, it is worth bringing up with your pharmacist or doctor.
What Coenzyme Q10 (CoQ10) does & food sources
CoQ10 helps cells produce energy and acts as an antioxidant; heart and muscle tissue use it heavily.
Common food sources:
- Organ meats and fatty fish
- Whole grains
- Nuts and seeds
HelloPharmacist pharmacist-reviewed education — separate from the licensed record above.
What to discuss with your clinician
There is no routine blood test for CoQ10 in everyday practice. If you have new, unexplained muscle symptoms on a medication linked to CoQ10 (statins are the best-known example), talk to your prescriber before changing anything — symptoms have many possible causes and your prescriber has several options.
HelloPharmacist pharmacist-reviewed education — separate from the licensed record above.
Supplement considerations
CoQ10 is generally well tolerated, but evidence for supplementing (for example, for statin muscle symptoms) is mixed. It may also modestly affect warfarin — check with your pharmacist before combining.
Do not start or stop medications or supplements without professional guidance — supplements can interact with prescription medications.
HelloPharmacist pharmacist-reviewed education — separate from the licensed record above.
Caution: Do not stop a prescribed medication because of this association — discuss any symptoms with your prescriber first.
Learn more about this nutrient: Coenzyme Q10 — uses, safety & interactions
References (1)
- Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. J Med 1976;7:307-21.
VITAMIN C
Insufficient EvidenceCALCIUM CHANNEL BLOCKERS
DCCBs inhibit uptake of vitamin C by intestinal cells in vitro. Whether this causes a clinically significant reduction in vitamin C absorption in humans is not known.
Amlodipine belongs to a class of blood pressure medications that, in lab studies, appears to interfere with how intestinal cells take up vitamin C, a nutrient your immune system, skin, and tissue repair all depend on. That said, nobody has confirmed this actually plays out in real people at meaningful levels, so the evidence right now is simply too thin to know whether it matters. Most people on amlodipine do not need to worry about this, but if you are curious or have concerns about your vitamin C intake, it is worth a quick conversation with your pharmacist or doctor.
What Vitamin C does & food sources
Vitamin C is an antioxidant that supports the immune system, collagen formation, and iron absorption.
Common food sources:
- Citrus fruits
- Bell peppers
- Strawberries and kiwi
- Broccoli and Brussels sprouts
HelloPharmacist pharmacist-reviewed education — separate from the licensed record above.
What to discuss with your clinician
Frank vitamin C deficiency is uncommon with a varied diet. If your diet is limited and you take an associated medication, ask your provider whether your intake is adequate.
HelloPharmacist pharmacist-reviewed education — separate from the licensed record above.
Supplement considerations
Vitamin C is water-soluble and generally low-risk at food-level intakes; very high supplemental doses can cause stomach upset and may not add benefit.
Do not start or stop medications or supplements without professional guidance — supplements can interact with prescription medications.
HelloPharmacist pharmacist-reviewed education — separate from the licensed record above.
Learn more about this nutrient: Vitamin C — uses, safety & interactions
References (1)
- Kuo SM, Lin CP, Morehouse HF Jr. Dihydropyridine calcium channel blockers inhibit ascorbic acid accumulation in human intestinal Caco-2 cells. Life Sci 2001;68:1751-60.. PubMed
This tool is educational and is not a substitute for professional medical advice. An association is not a diagnosis and does not mean a deficiency will occur. Always talk to your pharmacist or healthcare provider before starting, stopping, or changing any medication or supplement.
Disclaimer: This checker finds which nutrients might be depleted by prescription or over-the-counter medications. Each nutrient depletion issue is rated based on clinical significance. Use your own professional judgment prior to making clinical decisions.© 2026 Therapeutic Research Center Licensed records refresh weekly · last updated July 3, 2026.
More about Perindopril Arginine, Amlodipine
What drug-induced nutrient depletion means
Some medications can, over time, lower the levels of certain vitamins, minerals, or other nutrients — through reduced absorption, increased loss, or changes in how the body uses them.
Association is not deficiency
An entry here means a depletion has been reported or studied — not that it happens to everyone, or that you are deficient. Dose, duration, diet, and your own health all matter.
Evidence varies by pair
Some drug–nutrient links (like metformin and vitamin B12) are well studied; others rest on limited or preliminary research. Each entry shows the evidence rating from our licensed clinical database.
When to ask about labs
If you take an associated medication long-term, ask your healthcare provider whether monitoring is appropriate for you. Not everyone needs testing — your provider can weigh your dose, duration, and symptoms.
Don't self-supplement blindly
Supplements are not risk-free: some can interact with medications, and some (like potassium or magnesium) can be risky with kidney disease. Talk to your pharmacist before adding anything.
Never stop a medication over this
These medications are prescribed for good reasons, and the benefit usually far outweighs a manageable nutrient consideration. Any change belongs in a conversation with your prescriber.
Food first, usually
For many nutrients, a varied diet covers the gap. Each entry lists common food sources; a supplement is a decision to make with your pharmacist or provider, not a default.
Perindopril Arginine, Amlodipine & nutrients: FAQs
Does Perindopril Arginine, Amlodipine deplete COENZYME Q10?
Should I take a supplement because I take Perindopril Arginine, Amlodipine?
Should I stop taking Perindopril Arginine, Amlodipine?
Where does this information come from?
Questions about Perindopril Arginine, Amlodipine and your nutrition?
Ask a licensed pharmacist — free, no appointment needed.
Sources & How We Checked
Nutrient depletion records for Perindopril Arginine, Amlodipine are evidence-graded and sourced from the Natural Medicines database, and are displayed as published with their citations.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for drug-induced nutrient depletions, supplements, and interactions — the basis for this page.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for medication overviews across the site.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.