Coenzyme Q10 Interactions Overview

Check For Interactions With Coenzyme Q10

Coenzyme Q10

Also known as
  • CoQ10
Coenzyme Q10, also known as CoQ10, is a naturally occurring substance that is found in every cell of the body and plays an essential role in energy production within the mitochondria, which are the powerhouse of the cells. CoQ10 also acts as an antioxidant, protecting cells from damage caused by harmful free radicals. While CoQ10 is endogenous, meaning our body can produce it on its own, levels can decrease with age, with certain medications (e.g., statins) or due to certain medical conditions. In such cases, supplementation with CoQ10 may be beneficial. Additionally, CoQ10 supplements have been studied for a variety of health benefits, including improving heart health, reducing inflammation, and potentially even aiding in the treatment of neurological disorders such as Parkinson's disease. However, it's important to note that while some studies have shown potential benefits, the research on CoQ10 supplementation is still ongoing, and more studies are needed to fully understand its effects on the body.
There are 195 drugs known to interact with Coenzyme Q10

Does CoQ10 Interact With Any Drugs?

Interactions of CoQ10 with other medications and treatments are important to consider before supplementing with it.

Here are some potential interactions to keep in mind:

Antihypertensives

Coenzyme Q10 may have additive effects with antihypertensive drugs, and some clinical research has shown that it can significantly lower blood pressure. However, conflicting results have been reported.

It's important to monitor blood pressure closely and adjust medication doses as necessary if supplementing with CoQ10.

Warfarin

Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.

Concomitant use of CoQ10 and warfarin might reduce the anticoagulant effects of warfarin.

There have been at least four reported cases (one such report can be found here on PubMed) of decreased warfarin efficacy thought to be due to CoQ10. However, some preliminary clinical research suggests that CoQ10 might not significantly decrease the effects of warfarin in patients who have a stable INR.

Patients on warfarin should consult with their healthcare provider before supplementing with CoQ10.

Alkylating Agents

Coenzyme Q10 has antioxidant effects, which theoretically may reduce the activity of chemotherapy drugs that generate free radicals.

Antioxidants such as CoQ10 might also protect tumor cells from chemotherapeutic agents that work by inducing oxidative stress, such as alkylating agents (e.g., cyclophosphamide) and radiation therapy.

The clinical importance of this interaction is unknown, and it's important to consult with a healthcare provider before supplementing with CoQ10 during cancer treatment.

Drugs that interact with Coenzyme Q10

Return to the main supplement interaction checker page

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLCs