Drug-induced nutrient depletion

Medications That May Deplete RIBOFLAVIN

Riboflavin helps the body produce energy and process other B vitamins. See which medications carry a reported association, how strong the evidence is, and what to discuss with your pharmacist.

225Medications
225Depletion records
About RIBOFLAVIN

Riboflavin helps the body produce energy and process other B vitamins.

Common food sources: Dairy products and eggs; Lean meats; Fortified grains; Green vegetables.

Deficiency is uncommon with a varied diet; ask your provider if you have persistent mouth-corner cracking, sore tongue, or unexplained fatigue on a long-term associated medication.

HelloPharmacist pharmacist-reviewed education. The medication records below are licensed clinical data, shown as published.

Deep dive: Riboflavin — uses, safety & drug interactions

The evidence

Medications associated with RIBOFLAVIN depletion

Each record is shown as published in our licensed clinical database. Open a medication for its full nutrient report.

Amikacin

Insignificant Depletion

Brand names include Amikin, Arikayce

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Amikacin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to turn food into energy and keep skin and nerves healthy, is mainly absorbed from the foods you eat rather than from bacteria living in your gut. Amikacin, like other antibiotics, can disrupt those gut bacteria, which do produce a small amount of riboflavin on their own. That said, since dietary intake does most of the heavy lifting here, this disruption is considered insignificant in practice, and a riboflavin supplement is not something most people need while taking this medication.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Amikacin →

Amitriptyline

Insignificant Depletion

Brand names include Elavil

TCAs might reduce active riboflavin levels; however, this is not likely to be clinically significant.
TCAs have structural similarities to riboflavin and can interfere with its conversion to the active form flavin adenine dinucleotide (FAD). In animal models, very high doses of amitriptyline and imipramine (50 mg/kg daily) decrease FAD levels in the liver, heart, and brain. Lower doses (10 mg/kg daily) only affect levels in the heart. Since these doses are higher than those used therapeutically in humans, it is unlikely that the effect is clinically significant or that supplements are necessary.
Taking Amitriptyline? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body turn food into energy and keeps cells working properly. Amitriptyline has a chemical shape similar enough to riboflavin that it may interfere with how the body converts riboflavin into its active, usable form. That said, this effect has really only shown up in animal studies using doses far higher than what people take, so for most patients on amitriptyline this is considered insignificant and no supplement is needed. If you ever have questions about your nutrient levels, your pharmacist or doctor is a great first stop.

References (2)
  1. Pinto J, Huang YP, Rivlin RS. Inhibition of riboflavin metabolism in rat tissues by chlorpromazine, imipramine and amitriptyline. J Clin Invest 1981;67:1500-6. PubMed
  2. Pinto J, Huang YP, Pelliccione N, Rivlin RS. Cardiac sensitivity to the inhibitory effects of chlorpromazine, imipramine, and amitriptyline upon formation of flavins. Biochem Pharmacol 1982;31:3495-9.. PubMed

Full nutrient report for Amitriptyline →

Amitriptyline, Chlordiazepoxide

Insignificant Depletion

Brand names include Limbitrol DS

TCAs might reduce active riboflavin levels; however, this is not likely to be clinically significant.
TCAs have structural similarities to riboflavin and can interfere with its conversion to the active form flavin adenine dinucleotide (FAD). In animal models, very high doses of amitriptyline and imipramine (50 mg/kg daily) decrease FAD levels in the liver, heart, and brain. Lower doses (10 mg/kg daily) only affect levels in the heart. Since these doses are higher than those used therapeutically in humans, it is unlikely that the effect is clinically significant or that supplements are necessary.
Taking Amitriptyline, Chlordiazepoxide? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin is a B vitamin your body uses to convert food into energy and keep cells working properly. Amitriptyline shares some chemical features with riboflavin, and research suggests it may interfere with the step that turns riboflavin into its active, working form in the body. That said, this effect has really only been seen in animal studies using doses much higher than what people take, so for most patients this is not a practical concern. No action is needed for the majority of people, but if you have questions about your nutrition or this medication, your pharmacist or doctor is a great resource.

References (2)
  1. Pinto J, Huang YP, Rivlin RS. Inhibition of riboflavin metabolism in rat tissues by chlorpromazine, imipramine and amitriptyline. J Clin Invest 1981;67:1500-6. PubMed
  2. Pinto J, Huang YP, Pelliccione N, Rivlin RS. Cardiac sensitivity to the inhibitory effects of chlorpromazine, imipramine, and amitriptyline upon formation of flavins. Biochem Pharmacol 1982;31:3495-9.. PubMed

Full nutrient report for Amitriptyline, Chlordiazepoxide →

Amitriptyline, Perphenazine

Insignificant Depletion

Brand names include Triavil, Etrafon, Etrafon-A

TCAs might reduce active riboflavin levels; however, this is not likely to be clinically significant.
TCAs have structural similarities to riboflavin and can interfere with its conversion to the active form flavin adenine dinucleotide (FAD). In animal models, very high doses of amitriptyline and imipramine (50 mg/kg daily) decrease FAD levels in the liver, heart, and brain. Lower doses (10 mg/kg daily) only affect levels in the heart. Since these doses are higher than those used therapeutically in humans, it is unlikely that the effect is clinically significant or that supplements are necessary.
Taking Amitriptyline, Perphenazine? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin is a B vitamin your body uses to convert food into energy and keep cells working properly. Amitriptyline has a chemical shape that resembles riboflavin, and research suggests it may interfere with the step that turns riboflavin into its active, usable form in the body. That said, this effect has mainly been seen in animal studies using doses far higher than what people actually take, so for most patients this is not a practical concern. No action is needed for the vast majority of people, but if you have questions about your nutrition while on this medication, your pharmacist or doctor is a great place to start.

References (2)
  1. Pinto J, Huang YP, Rivlin RS. Inhibition of riboflavin metabolism in rat tissues by chlorpromazine, imipramine and amitriptyline. J Clin Invest 1981;67:1500-6. PubMed
  2. Pinto J, Huang YP, Pelliccione N, Rivlin RS. Cardiac sensitivity to the inhibitory effects of chlorpromazine, imipramine, and amitriptyline upon formation of flavins. Biochem Pharmacol 1982;31:3495-9.. PubMed

Full nutrient report for Amitriptyline, Perphenazine →

Amoxapine

Insignificant Depletion

Brand names include Asendin

TCAs might reduce active riboflavin levels; however, this is not likely to be clinically significant.
TCAs have structural similarities to riboflavin and can interfere with its conversion to the active form flavin adenine dinucleotide (FAD). In animal models, very high doses of amitriptyline and imipramine (50 mg/kg daily) decrease FAD levels in the liver, heart, and brain. Lower doses (10 mg/kg daily) only affect levels in the heart. Since these doses are higher than those used therapeutically in humans, it is unlikely that the effect is clinically significant or that supplements are necessary.
Taking Amoxapine? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin is a B vitamin your body uses to convert food into energy and keep cells running properly. Amoxapine belongs to a drug class whose molecular structure happens to look similar enough to riboflavin that it may interfere with the step that turns riboflavin into its active, working form inside the body. That said, the doses where researchers actually saw this effect in animals were far higher than anything prescribed to people, so for most patients taking amoxapine this is considered insignificant and no supplement is needed. If you ever have questions about your B vitamin intake, your pharmacist or doctor is a great place to start.

References (2)
  1. Pinto J, Huang YP, Rivlin RS. Inhibition of riboflavin metabolism in rat tissues by chlorpromazine, imipramine and amitriptyline. J Clin Invest 1981;67:1500-6. PubMed
  2. Pinto J, Huang YP, Pelliccione N, Rivlin RS. Cardiac sensitivity to the inhibitory effects of chlorpromazine, imipramine, and amitriptyline upon formation of flavins. Biochem Pharmacol 1982;31:3495-9.. PubMed

Full nutrient report for Amoxapine →

Amoxicillin

Insignificant Depletion

Brand names include Amoxil Capsules, Trimox, Wymox

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Amoxicillin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses for energy production and healthy cell function, is mostly absorbed from the food you eat rather than made by gut bacteria. Amoxicillin can disrupt those gut bacteria, which do produce a small amount of riboflavin, but research suggests that contribution is too minor to matter much in practice. For most people taking a course of amoxicillin, this is considered an insignificant concern and no riboflavin supplement is needed. That said, if you have questions about your diet or any antibiotic you are taking, your pharmacist is always a good first stop.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Amoxicillin →

Amoxicillin Veterinary

Insignificant Depletion

Brand names include Biomox

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Amoxicillin Veterinary? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body turn food into energy and keeps your skin, eyes, and nerves working properly. Amoxicillin, like other antibiotics, can alter the natural bacteria living in your gut, and those bacteria do produce a small amount of riboflavin. The key word there is small: your body gets the vast majority of riboflavin from food, so this shift in gut bacteria is not considered meaningful in practice. For most people taking this medication, no extra riboflavin is needed, though your pharmacist is always a good sounding board if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Amoxicillin Veterinary →

Amoxicillin, Clavulanate Potassium

Insignificant Depletion

Brand names include Augmentin, Augmentin XR, Clavulin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Amoxicillin, Clavulanate Potassium? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin and nervous system healthy. Amoxicillin-clavulanate, like other antibiotics, can disrupt the friendly bacteria living in your gut, and those bacteria do produce small amounts of riboflavin. That said, your gut bacteria contribute very little to your overall riboflavin supply since most of it comes straight from the food you eat, so this interaction is considered insignificant for the vast majority of people. No extra riboflavin is needed during a typical course of this antibiotic.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Amoxicillin, Clavulanate Potassium →

Brand names include Talicia

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Amoxicillin, Omeprazole Magnesium, Rifabutin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, sometimes called vitamin B2, is a nutrient your body uses to convert food into energy and keep skin and tissues healthy. Antibiotics like amoxicillin can disrupt the bacteria that live in your gut, and those bacteria do produce a small amount of riboflavin. The key word, though, is small: your body gets the vast majority of its riboflavin from food, so this interaction is considered insignificant. Most people taking this antibiotic combination do not need a riboflavin supplement, but if you have questions, your pharmacist is a great place to start.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Amoxicillin, Omeprazole Magnesium, Rifabutin →

Amphotericin, Tetracycline

Insignificant Depletion

Brand names include Mysteclin-F

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Amphotericin, Tetracycline? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to convert food into energy and keep your skin and cells healthy. Antibiotics like tetracycline can reduce the bacteria that normally live in your gut, and those bacteria do produce a small amount of riboflavin. That said, most of what you need comes from food, so this bacterial loss does not appear to make a meaningful difference. For most people taking these antibiotics, no extra riboflavin is needed, but feel free to bring it up with your pharmacist if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Amphotericin, Tetracycline →

Ampicillin

Insignificant Depletion

Brand names include Principen, Omnipen-N, Omnipen

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Ampicillin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses to convert food into energy and support healthy skin and nerves, can theoretically dip a little when you take ampicillin. The reason is that antibiotics like ampicillin can disrupt the friendly bacteria living in your gut, and those bacteria do produce small amounts of riboflavin. That said, your gut bacteria contribute very little to your overall riboflavin supply compared to what you get from food, so this is rated insignificant for most people. No riboflavin supplement is needed for a typical course of ampicillin, but feel free to ask your pharmacist if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Ampicillin →

Ampicillin, Sulbactam

Insignificant Depletion

Brand names include Unasyn

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Ampicillin, Sulbactam? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to convert food into energy and keep your skin and tissues healthy. Ampicillin-sulbactam, like other antibiotics, can disrupt the natural bacteria living in your gut, and those bacteria do make small amounts of riboflavin. That said, your body gets the vast majority of its riboflavin from the food you eat, so this disruption is considered insignificant for most people. No extra riboflavin supplement is typically needed during a course of this antibiotic, but your pharmacist is always a good resource if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Ampicillin, Sulbactam →

Avibactam Sodium, Ceftazidime

Insignificant Depletion

Brand names include Avycaz

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Avibactam Sodium, Ceftazidime? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin, eyes, and nerves working properly. Ceftazidime/avibactam is an antibiotic, and like other antibiotics it can shift the normal bacteria living in your gut. Those bacteria do make a small amount of riboflavin, so in theory disrupting them could nudge levels down a bit. In practice, your body gets the vast majority of riboflavin from food, not from gut bacteria, so the effect is considered insignificant for most patients. No extra supplement is needed, but if you have questions about your nutrition during treatment, your pharmacist or doctor is a great resource.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Avibactam Sodium, Ceftazidime →

Azithromycin

Insignificant Depletion

Brand names include Zithromax, Zmax, Azasite

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Azithromycin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses to convert food into energy and keep skin and tissue healthy, is obtained almost entirely from what you eat rather than from bacteria living in your gut. Azithromycin can temporarily disrupt those gut bacteria, which do produce a small amount of riboflavin, but that contribution is so minor that losing it rarely makes a real difference. For most people taking a short course of azithromycin, this is not something to worry about, and a riboflavin supplement is not needed. If you have questions about your nutrition during antibiotic therapy, your pharmacist or doctor is a good resource.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Azithromycin →

Aztreonam

Insignificant Depletion

Brand names include Azactam

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Aztreonam? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses to convert food into energy and support healthy skin and nerves, can theoretically dip a little when you take antibiotics like aztreonam. The reason is indirect: antibiotics disrupt the natural bacteria in your gut, and those bacteria do produce small amounts of riboflavin. That said, your gut bacteria contribute very little to your overall riboflavin supply compared to what you get from food, so this interaction is considered insignificant for most people. No riboflavin supplement is generally needed during a course of aztreonam, but your pharmacist is always happy to answer questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Aztreonam →

Bacampicillin

Insignificant Depletion

Brand names include Penglobe

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Bacampicillin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to turn food into energy and keep skin and nerves healthy, is found mostly in the foods you eat rather than being made inside your gut. Bacampicillin is an antibiotic, and like other antibiotics it can disrupt the bacteria that normally live in your intestines, which in theory could reduce a small amount of riboflavin those bacteria produce. In practice, because your diet supplies the vast majority of your riboflavin anyway, this effect is considered insignificant for most people. No supplement is generally needed, but if you have questions about your diet during a course of antibiotics, your pharmacist is a good place to start.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Bacampicillin →

Bacitracin

Insignificant Depletion

Brand names include Baci-IM, Bacitracin Ointment, Baciguent

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Bacitracin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body turn food into energy and keeps your skin and nervous system healthy. Bacitracin, like other antibiotics, can reduce the helpful bacteria living in your gut that make small amounts of riboflavin as a byproduct. That said, your body relies mainly on food for riboflavin, not on those bacteria, so this loss is considered insignificant. For most people using bacitracin, no extra riboflavin is needed, but feel free to mention it to your pharmacist if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Bacitracin →

Benznidazole

Insignificant Depletion
Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Benznidazole? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body turn food into energy and keeps skin, eyes, and nerves working properly. Benznidazole is an antibiotic, and antibiotics in general can slightly reduce the amount of riboflavin that gut bacteria produce. That said, your body gets the vast majority of its riboflavin from food rather than from bacteria, so this effect is considered insignificant for most people. No supplement is typically needed, but if you have questions about your diet while on this medication, your pharmacist or doctor is a great resource.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Benznidazole →

Birth control pills

Insignificant Depletion
Oral contraceptives might reduce riboflavin levels; however, this is not likely to be clinically significant.
Oral contraceptives may interfere with the absorption of riboflavin, or its conversion to active coenzyme forms. However, studies are conflicting. Some have found reduced levels of flavin adenine dinucleotide (FAD, the active form of riboflavin), reduced urinary riboflavin excretion, or reduced erythrocyte glutathione reductase activity consistent with riboflavin deficiency, in females taking oral contraceptives. However, many of these studies involved females with marginal or deficient dietary riboflavin intake, who used high-dose oral contraceptives (50 mcg ethinyl estradiol/day). When dietary riboflavin intake is adequate, no interaction with oral contraceptives is found. Routine riboflavin supplementation isn't necessary in females taking oral contraceptives.
Taking Birth control pills? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses to convert food into energy and keep cells working properly, may be affected slightly by birth control pills. Some research suggests the pill could interfere with how the gut absorbs riboflavin or how the body activates it, but studies have been mixed, and most of the concerns showed up in women who were already not getting enough riboflavin from food and were using older, higher-dose pills. If you eat a reasonably balanced diet, this is very unlikely to be an issue for you, though your pharmacist is always happy to talk it through if you have concerns.

References (9)
  1. Tyrer LB. Nutrition and the pill. J Reprod Med 1984;29:547-50..
  2. Newman LJ, Lopez R, Cole HS, et al. Riboflavin deficiency in women taking oral contraceptive agents. Am J Clin Nutr 1978;31:247-9.. PubMed
  3. Sanpitak N, Chayutimonkul L. Oral contraceptives and riboflavin nutrition. Lancet 1974;1:836-7.
  4. Ahmed F, Bamji MS, Iyengar L. Effect of oral contraceptive agents on vitamin nutrition status. Am J Clin Nutr 1975;28:606-15.. PubMed
  5. Briggs M. Oral contraceptives and vitamin nutrition (letter). Lancet 1974;1:1234-5. DOI
  6. Mooij PN, Thomas CM, Doesburg WH, Eskes TK. Multivitamin supplementation in oral contraceptive users. Contraception 1991;44:277-88. PubMed
  7. Roe DA, Bogusz S, Sheu J, et al. Factors affecting riboflavin requirements of oral contraceptive users and non-users. Am J Clin Nutr 1982;35:495-501..
  8. Lewis CM, King JC. Effect of oral contraceptive agents on thiamin, riboflavin, and pantothenic acid status in young women. Am J Clin Nutr 1980;33:832-8..
  9. Vir SC, Love AH. Riboflavin nutriture of oral contraceptive users. Int J Vitam Nutr Res 1979;49:286-90..

Full nutrient report for Birth control pills →

Brand names include Helidac

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Bismuth Subsalicylate, Metronidazole, Tetracycline? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin and eyes healthy. These antibiotics can disrupt the natural bacteria living in your gut, and those bacteria do produce small amounts of riboflavin. The good news is that your gut bacteria only contribute a minor fraction of your total riboflavin supply since most of it comes straight from the foods you eat. For most people taking this combination, no extra riboflavin is needed, but feel free to mention it to your pharmacist if you have any concerns.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Bismuth Subsalicylate, Metronidazole, Tetracycline →

Capreomycin

Insignificant Depletion

Brand names include Capastat

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Capreomycin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body relies on to convert food into usable energy and keep skin and nerves healthy, is mainly absorbed from what you eat rather than from bacteria living in your gut. Capreomycin, like other antibiotics, can disrupt those gut bacteria, which do produce a small amount of riboflavin on their own. That said, this bacterial contribution is a pretty minor piece of the puzzle, so the overall effect on your riboflavin supply is considered insignificant for most people. No supplement is generally needed here, but if you have concerns about your diet or nutritional status, your pharmacist or doctor is a good person to ask.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Capreomycin →

Carbenicillin Indanyl Sodium

Insignificant Depletion

Brand names include Geocillin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Carbenicillin Indanyl Sodium? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body turn food into energy and keeps skin, eyes, and nerves working well. Carbenicillin indanyl sodium is an antibiotic, and antibiotics in general can shift the balance of bacteria living in your gut, which normally produce small amounts of riboflavin. That said, your gut bacteria contribute very little to your overall riboflavin supply compared to what you get from food, so this interaction is rated insignificant. Most people taking this antibiotic do not need a riboflavin supplement, but feel free to ask your pharmacist if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Carbenicillin Indanyl Sodium →

Cefaclor

Insignificant Depletion

Brand names include Ceclor CD, Ceclor

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Cefaclor? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses for energy production and healthy cell function, is primarily absorbed from the foods you eat rather than made by gut bacteria. Cefaclor and other antibiotics can disrupt those bacteria, which do produce a small amount of riboflavin, but that contribution is considered minor enough that your overall levels are very unlikely to be affected in any meaningful way. For most people taking this antibiotic, this is simply not something to worry about, and a riboflavin supplement is not considered necessary. If you have specific concerns, your pharmacist or doctor is a great resource.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Cefaclor →

Cefadroxil

Insignificant Depletion

Brand names include Duricef, Ultracef, Cef-Tab

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Cefadroxil? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body needs for turning food into energy and keeping skin and eyes healthy, is mostly absorbed from what you eat rather than made by gut bacteria. Cefadroxil and other antibiotics can disrupt those bacteria, which in theory reduces a small backup source of riboflavin, but research suggests this barely affects your overall levels. The evidence rates this as insignificant, meaning most people taking a short antibiotic course do not need to worry or take a supplement. If you have any concerns, a quick conversation with your pharmacist is all you need.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Cefadroxil →

Cefamandole

Insignificant Depletion

Brand names include Mandol

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Cefamandole? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to turn food into energy and keep skin, eyes, and nerves working well. Like other antibiotics, cefamandole can disrupt the normal bacteria living in your gut, and those bacteria do make a small amount of riboflavin. The thing is, that bacterial contribution is pretty minor compared to what you get from food, so this interaction is considered insignificant for most people. No supplement is needed, but if you have questions about your diet while taking this antibiotic, your pharmacist is a great resource.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Cefamandole →

Cefazolin

Insignificant Depletion

Brand names include Ancef

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Cefazolin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses for energy production and healthy cell function, is something cefazolin has been loosely linked to lowering. The thinking is that antibiotics can disrupt the friendly bacteria living in your gut, and those bacteria do produce a small amount of riboflavin. In practice, though, your gut flora's contribution is pretty minor compared to what you get from food, so this interaction is considered insignificant for most people. No supplement is typically needed during a short course of cefazolin, but if you have questions about your diet or nutritional status, your pharmacist or doctor is a great person to ask.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Cefazolin →

Cefdinir

Insignificant Depletion

Brand names include Omnicef

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Cefdinir? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin is a B vitamin your body uses for energy production and keeping skin, eyes, and nerves healthy. Like other antibiotics, cefdinir can affect the natural bacteria living in your gut, and those bacteria do produce a small amount of riboflavin. That said, your body gets the vast majority of riboflavin from food, so this interaction is considered insignificant for most people. No extra supplement is needed during a short course of cefdinir, but if you have questions about your diet or vitamin intake, your pharmacist is happy to help.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Cefdinir →

Cefditoren Pivoxil

Insignificant Depletion

Brand names include Spectracef

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Cefditoren Pivoxil? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin, eyes, and nerves working properly. Cefditoren pivoxil, like other antibiotics, can temporarily shift the balance of bacteria in your gut, and those bacteria do produce a small amount of riboflavin. That said, most of your riboflavin comes from the food you eat, so this effect is considered insignificant for the vast majority of patients. No riboflavin supplement is typically needed while taking this antibiotic, but feel free to mention it to your pharmacist if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Cefditoren Pivoxil →

Cefepime

Insignificant Depletion

Brand names include Maxipime

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Cefepime? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin, eyes, and nerves working properly. Cefepime, like other antibiotics, can reduce the friendly bacteria living in your gut, and those bacteria do make a small amount of riboflavin. The catch is that your gut bacteria contribute very little to your overall riboflavin supply compared to what you get from food, so this effect is considered insignificant for most people. No riboflavin supplement is needed while taking cefepime, but feel free to mention it to your pharmacist if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Cefepime →

Cefiderocol Sulfate Tosylate

Insignificant Depletion

Brand names include Fetroja

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Cefiderocol Sulfate Tosylate? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses for energy production and keeping skin, nerves, and eyes healthy, may theoretically dip a little when you take any antibiotic, including cefiderocol. The thinking is that antibiotics can reduce the bacteria living in your gut, and those bacteria make small amounts of riboflavin. That said, your gut bacteria contribute very little to your riboflavin supply compared to what you get from food, so this is rated insignificant for most people. No riboflavin supplement is needed, but if you have questions, your pharmacist is happy to talk it through.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Cefiderocol Sulfate Tosylate →

Cefixime

Insignificant Depletion

Brand names include Suprax

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Cefixime? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to turn food into energy and keep skin and tissues healthy, is mostly absorbed through what you eat rather than made by gut bacteria. Cefixime, like other antibiotics, can disrupt the natural bacteria living in your intestines, and those bacteria do produce some riboflavin. That said, since diet is your main source, any drop from this effect is considered too small to matter clinically. For most people taking cefixime, no extra riboflavin is needed, but feel free to mention it to your pharmacist if you have any concerns.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Cefixime →

Cefmetazole

Insignificant Depletion

Brand names include Zefazone

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Cefmetazole? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses for energy production and keeping skin and nerves healthy, is mostly obtained from the foods you eat rather than from bacteria in your gut. Cefmetazole, like other antibiotics, can disrupt those gut bacteria and slightly reduce the small amount of riboflavin they produce, but this contribution to your overall supply is so minor that it rarely matters in practice. For most people taking this antibiotic, no extra riboflavin is needed. If you have any concerns, a quick conversation with your pharmacist is always a good idea.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Cefmetazole →

Cefonicid

Insignificant Depletion

Brand names include Monocid

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Cefonicid? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin and nervous system healthy. Like other antibiotics, cefonicid can disrupt the normal bacteria living in your gut, and those bacteria do produce a small amount of riboflavin. That said, most of what your body needs comes from food, so this disruption is considered insignificant in practice. For the vast majority of people taking cefonicid, no extra riboflavin is needed, though feel free to mention any concerns to your pharmacist.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Cefonicid →

Cefoperazone

Insignificant Depletion

Brand names include Cefobid

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Cefoperazone? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to convert food into energy and keep skin and eyes healthy, can technically be reduced by antibiotics like cefoperazone because these drugs disrupt the friendly bacteria in your gut that produce small amounts of it. That said, those gut bacteria contribute very little to your overall riboflavin supply since most of it comes straight from food. Given the insignificant rating here, this is not a practical concern for most people taking this antibiotic, and a riboflavin supplement is not generally needed.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Cefoperazone →

Cefotaxime

Insignificant Depletion

Brand names include Claforan

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Cefotaxime? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body turn food into energy and keeps your skin and eyes healthy. Cefotaxime, like other antibiotics, can temporarily shift the balance of bacteria in your gut, and those bacteria normally make small amounts of riboflavin. Even so, because your body gets the vast majority of riboflavin from the food you eat, this effect is considered insignificant for most people. No supplement is needed for the typical course of this antibiotic, but feel free to mention it to your pharmacist if you have concerns.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Cefotaxime →

Cefotetan

Insignificant Depletion

Brand names include Cefotan

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Cefotetan? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to turn food into energy and keep your skin and cells healthy. Cefotetan, like other antibiotics, can reduce the gut bacteria that produce small amounts of riboflavin as a byproduct, but here is the reassuring part: your body gets the vast majority of its riboflavin from food, not from those bacteria. The evidence rates this as insignificant, meaning most people taking this antibiotic have nothing to worry about and do not need a supplement. If you have any concerns, your pharmacist or doctor is always a good place to start.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Cefotetan →

Cefoxitin

Insignificant Depletion

Brand names include Mefoxin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Cefoxitin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to turn food into energy and keep skin and nerves healthy, is mainly absorbed from the foods you eat rather than made by gut bacteria. Cefoxitin, like other antibiotics, can disrupt the natural bacteria in your intestines that produce small amounts of riboflavin, but that bacterial contribution is so minor that it rarely matters in practice. For most people taking this antibiotic, a riboflavin supplement is simply not necessary. If you have concerns, a quick chat with your pharmacist can put your mind at ease.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Cefoxitin →

Cefpodoxime Proxetil

Insignificant Depletion

Brand names include Vantin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Cefpodoxime Proxetil? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body turn food into energy and keeps your skin and nervous system healthy. Cefpodoxime, like other antibiotics, can shift the balance of bacteria living in your gut, and some of those bacteria normally make small amounts of riboflavin. In practice though, your body gets the vast majority of its riboflavin from food, so this bacterial change is unlikely to matter much. The evidence rates this as insignificant, meaning most people taking this antibiotic do not need a riboflavin supplement, but feel free to mention it to your pharmacist if you have any concerns.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Cefpodoxime Proxetil →

Cefprozil

Insignificant Depletion

Brand names include Cefzil

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Cefprozil? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body turn food into energy and keeps your skin, eyes, and nerves working properly. Cefprozil, like other antibiotics, can temporarily affect the bacteria living in your gut, and those bacteria do make small amounts of riboflavin. That said, your gut bacteria contribute very little to your overall riboflavin supply since most of it comes from food, so this is rated as an insignificant depletion for most people. No extra supplement is needed, but feel free to mention it to your pharmacist if you have any concerns.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Cefprozil →

Ceftazidime

Insignificant Depletion

Brand names include Fortaz, Tazidime, Ceptaz

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Ceftazidime? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses for energy production and healthy cell function, can technically be affected by antibiotics like ceftazidime because these drugs alter the bacteria that normally live in your gut, and those bacteria produce small amounts of riboflavin. That said, your diet is really what keeps your riboflavin levels up, so this bacterial change has little practical impact. For most people taking ceftazidime, this is a non-issue and no supplement is needed. If you have broader concerns about nutrition during antibiotic treatment, a quick chat with your pharmacist is always a good idea.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Ceftazidime →

Ceftibuten

Insignificant Depletion

Brand names include Cedax

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Ceftibuten? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses for energy production and healthy cell function, is mainly absorbed from the foods you eat rather than from bacteria living in your gut. Ceftibuten, like other antibiotics, can temporarily disrupt those gut bacteria, which do produce small amounts of riboflavin, but that bacterial contribution is so minor that losing it rarely makes a real difference. For most people taking a short course of ceftibuten, this is not something to worry about, and a riboflavin supplement is generally not needed. That said, if you have questions about your diet or any supplements, your pharmacist is always happy to talk it through.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Ceftibuten →

Ceftizoxime

Insignificant Depletion

Brand names include Cefizox

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Ceftizoxime? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin, eyes, and nerves healthy. Ceftizoxime, like other antibiotics, can disrupt the friendly bacteria in your gut that normally produce small amounts of riboflavin. That said, your body gets the vast majority of its riboflavin from food rather than gut bacteria, so this effect is considered insignificant for most people. No extra supplement is needed, but if you have questions about your diet while on this antibiotic, your pharmacist is a great person to ask.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Ceftizoxime →

Ceftolozane Sulfate, Tazobactam Sodium

Insignificant Depletion

Brand names include Zerbaxa

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Ceftolozane Sulfate, Tazobactam Sodium? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body turn food into energy and keeps your skin, eyes, and nerves working properly. Antibiotics like this one can disrupt the normal bacteria living in your gut, and those bacteria do produce a small amount of riboflavin. Even so, that bacterial contribution is minor compared to what you get from food, so any effect on your riboflavin levels is considered insignificant. Most people on this medication have nothing to worry about here, and a riboflavin supplement is not needed for the average patient.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Ceftolozane Sulfate, Tazobactam Sodium →

Ceftriaxone

Insignificant Depletion

Brand names include Rocephin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Ceftriaxone? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to turn food into energy and keep skin and tissues healthy, can in theory drop a little when you take antibiotics like ceftriaxone. The thinking is that antibiotics clear out some of the gut bacteria that produce small amounts of riboflavin, but those bacteria actually contribute very little to what your body needs overall since most riboflavin comes from the food you eat. The evidence rates this as insignificant, so for most people taking ceftriaxone there is nothing extra to do. No supplement is generally needed, but if you have questions about your diet or nutrition during treatment, your pharmacist or doctor is always a good person to ask.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Ceftriaxone →

Cefuroxime

Insignificant Depletion

Brand names include Ceftin, Kefurox, Zinacef

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Cefuroxime? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body turn food into energy and keeps your skin and nervous system healthy. Cefuroxime, like other antibiotics, can temporarily alter the natural bacteria living in your gut, and those bacteria do produce small amounts of riboflavin. That said, your body gets the vast majority of its riboflavin from food rather than gut bacteria, so this interaction is considered insignificant for most people. No riboflavin supplement is typically needed during a short course of this antibiotic, but your pharmacist is always happy to answer questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Cefuroxime →

Cephalexin

Insignificant Depletion

Brand names include Keflex, Keftab, Cephalex

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Cephalexin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses for energy production and cell repair, can theoretically dip a little when you take an antibiotic like cephalexin. The thinking is that antibiotics disrupt the friendly bacteria in your gut, which normally produce small amounts of riboflavin. That said, because your body gets most of its riboflavin from food rather than gut bacteria, this effect is considered insignificant for most people. No extra supplement is needed, but feel free to mention it to your pharmacist if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Cephalexin →

Cephapirin

Insignificant Depletion

Brand names include Cefadyl

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Cephapirin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to convert food into energy and keep your skin, eyes, and nerves working well. Cephapirin is an antibiotic, and like other antibiotics it can disrupt the helpful bacteria that normally live in your gut, which means a small amount of riboflavin those bacteria would produce gets lost. That said, your gut bacteria only make a tiny fraction of your riboflavin anyway since most of it comes straight from what you eat, so this effect is considered insignificant for the vast majority of people. No extra riboflavin supplement is needed while taking this medication.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Cephapirin →

Cephradine

Insignificant Depletion

Brand names include Velosef, Anspor

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Cephradine? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses for energy production and healthy cell function, can theoretically dip a little when you take an antibiotic like cephradine. The thinking is that antibiotics can disrupt the friendly bacteria living in your gut, and those bacteria do produce small amounts of riboflavin. That said, your gut bacteria contribute very little to your overall riboflavin supply compared to what you get from food, so this is rated as insignificant and no supplement is needed for most people. If you have concerns, a quick chat with your pharmacist is always a good idea.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Cephradine →

Chloramphenicol

Insignificant Depletion

Brand names include Chloromycetin, Chloromycetin Ophthalmic, Chloromycetin Injection

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Chloramphenicol? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body relies on for turning food into energy and keeping skin and nerves healthy, can theoretically dip a little when you take chloramphenicol. The antibiotic alters the normal bacteria living in your gut, and those bacteria do produce small amounts of riboflavin. That said, your diet supplies the vast majority of what your body needs, so this is considered an insignificant concern for most people. No riboflavin supplement is typically needed during a course of chloramphenicol, but feel free to mention it to your pharmacist if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Chloramphenicol →

Chlortetracycline

Insignificant Depletion

Brand names include Aureomycin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Chlortetracycline? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses to turn food into energy and keep your skin and eyes healthy, can theoretically dip a little when you take an antibiotic like chlortetracycline. The thinking is that antibiotics knock back the normal bacteria living in your gut, and those bacteria make small amounts of riboflavin. That said, your gut bacteria contribute only a tiny fraction of the riboflavin you get, and the rest comes easily from everyday foods like dairy, eggs, and leafy greens. The evidence rates this as insignificant, so for most people taking chlortetracycline there is really nothing extra to do, but feel free to mention it to your pharmacist if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Chlortetracycline →

Cinoxacin

Insignificant Depletion

Brand names include Cinobac

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Cinoxacin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to convert food into energy and keep skin, eyes, and nerves healthy. Cinoxacin is an antibiotic, and like other antibiotics, it can alter the natural bacteria living in your gut that produce small amounts of riboflavin. That said, your gut bacteria actually contribute very little to your overall riboflavin supply since most of it comes straight from the foods you eat. This interaction is rated insignificant, meaning the large majority of people taking cinoxacin have no reason to add a riboflavin supplement, though your pharmacist is always a good person to ask if you have concerns.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Cinoxacin →

Ciprofloxacin

Insignificant Depletion

Brand names include Cipro, Ciprobay, Cipro XR

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Ciprofloxacin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to convert food into energy and keep skin, eyes, and nerves working well. Ciprofloxacin, like other antibiotics, can disrupt the friendly bacteria living in your gut, and those bacteria do produce a small amount of riboflavin. That said, your gut bacteria contribute very little to your overall riboflavin supply since you get the vast majority from food, so this is rated insignificant. For most people taking ciprofloxacin, no extra riboflavin is needed, but feel free to mention it to your pharmacist if you have any concerns.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Ciprofloxacin →

Clarithromycin

Insignificant Depletion

Brand names include Biaxin, Biaxin XL

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Clarithromycin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses for energy production and keeping your skin, eyes, and nerves healthy. Clarithromycin, like other antibiotics, can disrupt the natural bacteria living in your gut, and those bacteria do produce small amounts of riboflavin. That said, your body gets the vast majority of riboflavin from food, not from gut bacteria, so this disruption has not been shown to matter in any meaningful way. For most people taking clarithromycin, no extra riboflavin is needed, but feel free to mention it to your pharmacist if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Clarithromycin →

Clinafloxacin

Insignificant Depletion
Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Clinafloxacin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body counts on for turning food into energy and keeping your skin and nerves healthy. Clinafloxacin, like other antibiotics, can disrupt the friendly bacteria in your gut that produce small amounts of riboflavin, but here's the reassuring part: your body gets the vast majority of its riboflavin from the food you eat, not from those bacteria. The evidence rates this as insignificant, meaning a supplement is not considered necessary for most people taking this antibiotic. As always, if you have concerns about your nutrition during treatment, a quick chat with your pharmacist or doctor can put your mind at ease.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Clinafloxacin →

Clindamycin

Insignificant Depletion

Brand names include Cleocin, Dalacin C, Cleocin T Gel

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Clindamycin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to turn food into energy and keep skin and nerves healthy, is mainly absorbed from the food you eat rather than produced by gut bacteria. Clindamycin, like other antibiotics, can disrupt the natural bacteria living in your intestines, and those bacteria do make a small amount of riboflavin. Even so, that bacterial contribution is considered minor, so any dip in riboflavin levels is not expected to be meaningful in practice. For most people taking a course of clindamycin, there is no need to add a riboflavin supplement, but feel free to bring it up with your pharmacist if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Clindamycin →

Clofazimine

Insignificant Depletion

Brand names include Lamprene

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Clofazimine? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to turn food into energy and keep skin and nerves healthy, comes almost entirely from what you eat rather than from bacteria in your gut. Clofazimine, like other antibiotics, can shift the normal balance of gut bacteria, and those bacteria do produce a small amount of riboflavin. The thing is, that bacterial contribution is so minor that disrupting it does not appear to matter much in practice. This interaction is rated insignificant, so most people taking clofazimine do not need a riboflavin supplement, though you are always welcome to bring it up with your pharmacist if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Clofazimine →

Clomipramine

Insignificant Depletion

Brand names include Anafranil, Anafranil SR

TCAs might reduce active riboflavin levels; however, this is not likely to be clinically significant.
TCAs have structural similarities to riboflavin and can interfere with its conversion to the active form flavin adenine dinucleotide (FAD). In animal models, very high doses of amitriptyline and imipramine (50 mg/kg daily) decrease FAD levels in the liver, heart, and brain. Lower doses (10 mg/kg daily) only affect levels in the heart. Since these doses are higher than those used therapeutically in humans, it is unlikely that the effect is clinically significant or that supplements are necessary.
Taking Clomipramine? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is a nutrient your body uses to convert food into energy and keep cells working properly. Clomipramine belongs to a class of antidepressants that share a chemical shape similar to riboflavin, and that structural overlap may interfere with how the body activates riboflavin into its working form. That said, this effect has mainly shown up in animal studies using doses far higher than what people take, so for most patients this is considered insignificant and no supplement is needed. If you have concerns, it is always fine to bring it up with your pharmacist or doctor.

References (2)
  1. Pinto J, Huang YP, Rivlin RS. Inhibition of riboflavin metabolism in rat tissues by chlorpromazine, imipramine and amitriptyline. J Clin Invest 1981;67:1500-6. PubMed
  2. Pinto J, Huang YP, Pelliccione N, Rivlin RS. Cardiac sensitivity to the inhibitory effects of chlorpromazine, imipramine, and amitriptyline upon formation of flavins. Biochem Pharmacol 1982;31:3495-9.. PubMed

Full nutrient report for Clomipramine →

Cloxacillin Sodium

Insignificant Depletion

Brand names include Tegopen, Cloxi, Cloxapen

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Cloxacillin Sodium? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to convert food into energy and keep skin and nerves healthy, can theoretically dip a little when you take an antibiotic like cloxacillin. The thinking is that antibiotics can disrupt the friendly bacteria living in your gut, and those bacteria do produce small amounts of riboflavin. That said, your gut bacteria contribute very little to your overall riboflavin supply since most of it comes straight from food, so this interaction is considered insignificant for most people. No riboflavin supplement is typically needed, but if you have questions about your diet while on antibiotics, your pharmacist is a good person to ask.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Cloxacillin Sodium →

Colistimethate

Insignificant Depletion

Brand names include Coly-Mycin M

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Colistimethate? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses for energy production and keeping skin and tissues healthy, is obtained almost entirely from the foods you eat rather than from bacteria living in your gut. Colistimethate, like other antibiotics, can disrupt those gut bacteria, which do make a small amount of riboflavin, but that contribution is so minor that losing it rarely matters. For most people taking this medication, this is considered an insignificant concern and no supplement is needed. That said, if you have questions about your nutrition during treatment, your pharmacist or doctor is a great resource.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Colistimethate →

Cyclacillin

Insignificant Depletion

Brand names include Cyclapen-W, Cylcapen

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Cyclacillin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses for energy production and keeping skin and nerves healthy, may theoretically dip a little when you take an antibiotic like cyclacillin. The idea is that antibiotics can disrupt the friendly bacteria in your gut that produce small amounts of riboflavin, but here is the reassuring part: your body gets the vast majority of its riboflavin from food anyway, so losing that bacterial contribution rarely matters. For most people taking a short course of cyclacillin, this is not something to worry about, and no supplement is typically needed. That said, if you have any concerns, your pharmacist is always a good person to ask.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Cyclacillin →

Cycloserine

Insignificant Depletion

Brand names include Seromycin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Cycloserine? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to convert food into energy and keep skin and nerves healthy, can theoretically dip when taking antibiotics like cycloserine because these medicines may disrupt the gut bacteria that produce small amounts of it. That said, most of your riboflavin comes from food, not bacteria, so this effect is considered insignificant for the vast majority of people. No supplement is typically needed during cycloserine therapy, but if you have questions about your diet or nutrition, your pharmacist or doctor is a good person to ask.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Cycloserine →

Dalbavancin Hydrochloride

Insignificant Depletion

Brand names include Dalvance

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Dalbavancin Hydrochloride? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to convert food into energy and keep your skin, nerves, and eyes healthy. Dalbavancin is an antibiotic, and antibiotics in general can slightly reduce the amount of riboflavin that bacteria in your gut would otherwise produce. That said, your gut bacteria contribute very little to your riboflavin supply anyway since you get most of it from food, so this interaction is considered insignificant for most people. No riboflavin supplement is typically needed during treatment with this medication, but feel free to mention it to your pharmacist if you have any concerns.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Dalbavancin Hydrochloride →

Dapsone

Insignificant Depletion

Brand names include Avlosulfon, Aczone

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Dapsone? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to turn food into energy and keep skin and nerves healthy, may dip slightly when taking an antibiotic like dapsone, because antibiotics can disrupt the gut bacteria that produce small amounts of it. That said, this bacterial production is a minor source compared to what you get from food, so the effect is considered insignificant for most people. No riboflavin supplement is generally needed during dapsone therapy, but if you have any concerns, your pharmacist or doctor is the right person to ask.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Dapsone →

Daptomycin

Insignificant Depletion

Brand names include Cubicin, Dapzura RT

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Daptomycin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to convert food into energy and keep skin, nerves, and eyes healthy. Like other antibiotics, daptomycin may slightly reduce the friendly gut bacteria that produce a small amount of riboflavin on their own. In practice, though, your diet does the heavy lifting when it comes to riboflavin, so this is considered an insignificant concern for most patients. No supplement is generally needed, but feel free to mention it to your pharmacist if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Daptomycin →

Demeclocycline

Insignificant Depletion

Brand names include Declomycin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Demeclocycline? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses for energy production and healthy cell function, can theoretically dip a little when you take antibiotics like demeclocycline. The thinking is that antibiotics may disrupt the bacteria living in your gut, and those bacteria normally produce small amounts of riboflavin. That said, your diet is really where most of your riboflavin comes from, so this bacterial contribution is considered pretty minor. The evidence rates this as insignificant for most people, meaning a riboflavin supplement is generally not needed during a course of demeclocycline.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Demeclocycline →

Desipramine

Insignificant Depletion

Brand names include Norpramin, Pertofrane

TCAs might reduce active riboflavin levels; however, this is not likely to be clinically significant.
TCAs have structural similarities to riboflavin and can interfere with its conversion to the active form flavin adenine dinucleotide (FAD). In animal models, very high doses of amitriptyline and imipramine (50 mg/kg daily) decrease FAD levels in the liver, heart, and brain. Lower doses (10 mg/kg daily) only affect levels in the heart. Since these doses are higher than those used therapeutically in humans, it is unlikely that the effect is clinically significant or that supplements are necessary.
Taking Desipramine? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin is a B vitamin your body uses to convert food into energy and keep cells running properly. Desipramine belongs to a drug class that shares a similar chemical shape to riboflavin, and there is some evidence it can interfere with the step that turns riboflavin into its active, working form inside the body. That said, this effect has mainly been seen in animal studies using doses far higher than what people take, so for most patients this is considered insignificant and no supplement is typically needed. If you have any concerns, it is always fine to bring them up with your pharmacist or doctor.

References (2)
  1. Pinto J, Huang YP, Rivlin RS. Inhibition of riboflavin metabolism in rat tissues by chlorpromazine, imipramine and amitriptyline. J Clin Invest 1981;67:1500-6. PubMed
  2. Pinto J, Huang YP, Pelliccione N, Rivlin RS. Cardiac sensitivity to the inhibitory effects of chlorpromazine, imipramine, and amitriptyline upon formation of flavins. Biochem Pharmacol 1982;31:3495-9.. PubMed

Full nutrient report for Desipramine →

Dicloxacillin Injection

Insignificant Depletion

Brand names include Dynapen Injection

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Dicloxacillin Injection? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin and nervous system healthy. Dicloxacillin, like other antibiotics, can disrupt the natural bacteria living in your gut, and those bacteria normally produce a small amount of riboflavin. That said, the gut bacteria contribution to your riboflavin supply is quite minor since most of it comes from what you eat, so this interaction is rated insignificant. For the vast majority of people receiving this antibiotic, no extra riboflavin is needed, but feel free to ask your pharmacist if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Dicloxacillin Injection →

Dicloxacillin Sodium

Insignificant Depletion

Brand names include Dynapen, Pathocil, Dycill

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Dicloxacillin Sodium? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, sometimes called vitamin B2, is a nutrient your body uses to turn food into energy and keep your skin and eyes healthy. Dicloxacillin is an antibiotic, and like other antibiotics it can disrupt the helpful bacteria that normally live in your gut, which do produce small amounts of riboflavin on their own. That said, most of what your body needs comes from food, not from gut bacteria, so this effect is considered insignificant for most people. No extra riboflavin is typically needed while you are taking this medication, but feel free to mention it to your pharmacist if you have any concerns.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Dicloxacillin Sodium →

Dirithromycin

Insignificant Depletion

Brand names include Dynabac

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Dirithromycin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to turn food into energy and keep skin and nerves healthy, comes almost entirely from what you eat rather than from gut bacteria. Dirithromycin, like other antibiotics, can temporarily shift the normal bacteria living in your intestines, and those bacteria do make a small amount of riboflavin on their own. Because that bacterial contribution is so minor compared to what a normal diet provides, this interaction is considered insignificant for most people, and a riboflavin supplement is not needed during a course of this antibiotic.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Dirithromycin →

Doripenem

Insignificant Depletion

Brand names include Doribax

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Doripenem? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to convert food into energy and keep your skin, eyes, and nerves working well. Doripenem is an antibiotic, and like other antibiotics it can disrupt the natural bacteria living in your gut, which normally produce small amounts of riboflavin on their own. That said, your gut bacteria are not a major source of this vitamin anyway since most of it comes straight from the foods you eat, so this interaction is considered insignificant for most people. No riboflavin supplement is needed during a course of doripenem, but feel free to mention it to your pharmacist if you have any questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Doripenem →

Doxycycline

Insignificant Depletion

Brand names include Vibra-Tabs, Vibramycin, Doryx

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Doxycycline? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body needs to convert food into energy and keep your skin and cells healthy. Doxycycline, like other antibiotics, can affect the helpful bacteria living in your gut that normally produce small amounts of riboflavin as a byproduct. Here is the reassuring part: your body gets the vast majority of its riboflavin from food anyway, so that bacterial contribution is pretty minor. For most people taking doxycycline, this is not a practical concern and a riboflavin supplement is not called for, though your pharmacist is always happy to talk it through if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Doxycycline →

Doxycycline Hyclate

Insignificant Depletion

Brand names include Acticlate, Acticlate Cap, Lymepak

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Doxycycline Hyclate? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body turn food into energy and keeps your skin and nervous system healthy. Doxycycline, like other antibiotics, can disrupt the natural bacteria living in your gut, and those bacteria do make small amounts of riboflavin. That said, your gut bacteria contribute very little to your overall riboflavin supply since most of it comes from what you eat, so this interaction is considered insignificant for most people. No riboflavin supplement is needed during a course of doxycycline, but if you have questions about your diet or a specific concern, your pharmacist is a great place to start.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Doxycycline Hyclate →

Doxycycline monohydrate

Insignificant Depletion

Brand names include Erfacea

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Doxycycline monohydrate? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to convert food into energy and keep your cells working properly. Doxycycline, like other antibiotics, can disrupt the natural bacteria living in your gut, and those bacteria do produce a small amount of riboflavin. The key word there is small: your body gets the vast majority of its riboflavin from food, so this disruption has not been shown to cause any meaningful drop in your levels. For most people taking doxycycline, there is nothing to worry about here, and no supplement is needed.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Doxycycline monohydrate →

Doxycyline

Insignificant Depletion

Brand names include Doxychel

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Doxycyline? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses to convert food into energy and keep skin and eyes healthy, can technically be affected by doxycycline because antibiotics may shift the bacteria living in your gut, and those bacteria do produce a small amount of riboflavin. That said, this effect is rated insignificant, because your body gets the vast majority of its riboflavin from food rather than from gut bacteria. For most people taking doxycycline, there is no need to worry about this or reach for a supplement, but feel free to mention it to your pharmacist if you have any concerns.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Doxycyline →

Enoxacin

Insignificant Depletion

Brand names include Penetrex

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Enoxacin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin, eyes, and nerves working properly. Enoxacin, like other antibiotics, can temporarily disrupt the friendly bacteria living in your gut, and those bacteria do make small amounts of riboflavin. That said, your body gets the vast majority of its riboflavin from the food you eat, so this bacterial disruption is considered insignificant in practice. For most people taking enoxacin, no extra riboflavin is needed, but if you have concerns, your pharmacist is a great first stop.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Enoxacin →

Ertapenem

Insignificant Depletion

Brand names include Invanz

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Ertapenem? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin, eyes, and nerves working properly. Ertapenem is an antibiotic, and antibiotics in general can reduce the number of helpful bacteria living in your gut, which normally produce small amounts of riboflavin. That said, your gut bacteria contribute very little to your overall riboflavin supply compared to the food you eat, so this interaction is considered insignificant for most people. No supplement is needed for the typical course of this medication, but your pharmacist is always happy to answer questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Ertapenem →

Erythromycin

Insignificant Depletion

Brand names include Erythro S, PCE, E-Mycin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Erythromycin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses for energy production and keeping skin and nerves healthy, is absorbed mainly through the food you eat. Erythromycin, like other antibiotics, can disrupt the normal bacteria living in your gut, and those bacteria do produce small amounts of riboflavin. That said, since your diet does most of the heavy lifting here, losing that bacterial contribution is not considered meaningful for most people. This interaction is rated insignificant, so extra riboflavin is not something you need to worry about during a course of erythromycin.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Erythromycin →

Erythromycin Ethylsuccinate

Insignificant Depletion

Brand names include E.E.S. 400, E.E.S. Chewable, Wyamycin S

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Erythromycin Ethylsuccinate? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is a nutrient your body needs to convert food into energy and keep your skin and tissues healthy. Erythromycin, like other antibiotics, can temporarily shift the mix of bacteria living in your gut, and those bacteria do produce a small amount of riboflavin. That said, your body gets the vast majority of riboflavin from food rather than gut bacteria, so this interaction is considered insignificant for most people. No extra riboflavin supplement is needed while taking this antibiotic, but if you have any concerns, a quick chat with your pharmacist is always a good idea.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Erythromycin Ethylsuccinate →

Brand names include Pediazole

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Erythromycin Ethylsuccinate, Sulfisoxazole? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin and nerves working properly. This antibiotic combination can mildly disrupt the helpful bacteria in your gut that produce small amounts of riboflavin, but here is the reassuring part: your body gets the vast majority of its riboflavin from food, not from gut bacteria, so this effect is considered insignificant. For most people taking this medication, no extra riboflavin is needed. If you have concerns, a quick conversation with your pharmacist can put your mind at ease.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Erythromycin Ethylsuccinate, Sulfisoxazole →

Erythromycin Gluceptate

Insignificant Depletion
Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Erythromycin Gluceptate? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body counts on for turning food into usable energy and keeping your skin and tissues healthy. There is some thought that antibiotics like erythromycin gluceptate might slightly lower riboflavin by disrupting the friendly bacteria in your gut that normally produce small amounts of it. That said, your gut bacteria are only a minor source of riboflavin anyway since most of what you need comes straight from food, so this interaction is rated as insignificant for most people. No riboflavin supplement is expected to be necessary here, but if you ever have questions about your diet or vitamins while on an antibiotic, your pharmacist is a great first stop.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Erythromycin Gluceptate →

Erythromycin Lactobionate

Insignificant Depletion
Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Erythromycin Lactobionate? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses to convert food into energy and keep skin and eyes healthy, can theoretically dip when you take antibiotics like erythromycin lactobionate. The thinking is that antibiotics disrupt the normal bacteria living in your gut, and those bacteria do produce a small amount of riboflavin. In practice, though, your gut bacteria contribute very little to your overall riboflavin supply since most of it comes straight from the foods you eat, so this is rated as an insignificant concern. For the vast majority of people taking this antibiotic, no extra riboflavin is needed, but feel free to mention it to your pharmacist if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Erythromycin Lactobionate →

Erythromycin Stearate

Insignificant Depletion

Brand names include Erythro-S, Erythrocin, Ethril

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Erythromycin Stearate? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body turn food into energy and keeps your skin and nerves healthy. Erythromycin, like other antibiotics, can affect the friendly bacteria that live in your gut, and those bacteria do produce small amounts of riboflavin. The thing is, your gut bacteria contribute very little to your overall riboflavin supply since most of it comes straight from food like eggs, dairy, and leafy greens. For most people taking a course of erythromycin, this is not a concern worth acting on, but feel free to mention it to your pharmacist if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Erythromycin Stearate →

Erythromycin, Sulfisoxazole

Insignificant Depletion

Brand names include Eryzole

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Erythromycin, Sulfisoxazole? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin, eyes, and nerves working properly. Antibiotics like erythromycin and sulfisoxazole can alter the normal bacteria living in your gut, and those bacteria do produce small amounts of riboflavin. The key word, though, is small: your body gets the vast majority of its riboflavin from the food you eat, so this interaction is considered insignificant for most people. No extra supplementation is typically needed, but if you have questions about your diet or a specific concern, your pharmacist is a great person to ask.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Erythromycin, Sulfisoxazole →

Fidaxomicin

Insignificant Depletion

Brand names include Dificid

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Fidaxomicin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses for energy production and healthy cell function, is obtained mainly from the foods you eat rather than from gut bacteria. Fidaxomicin, like other antibiotics, can disrupt the natural bacteria living in your intestines, and those bacteria do make a small amount of riboflavin. That said, this bacterial contribution appears to be minor, and the overall effect on your riboflavin levels is considered insignificant for most people. No supplement is typically needed during a short course of fidaxomicin, but feel free to mention any concerns to your pharmacist.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Fidaxomicin →

Finafloxacin

Insignificant Depletion

Brand names include Xtoro

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Finafloxacin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses to convert food into energy and keep skin and nerves healthy, is obtained almost entirely from what you eat rather than from bacteria living in your gut. Like other antibiotics, finafloxacin can disrupt those gut bacteria, which do produce a small amount of riboflavin, but that bacterial contribution is so minor that losing it rarely causes any real shortage. For most people taking finafloxacin, this is not something to worry about, and a riboflavin supplement is generally not needed. If you have questions about your diet or nutrient levels, your pharmacist or doctor is a great person to ask.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Finafloxacin →

Flucloxacillin

Insignificant Depletion

Brand names include Staphylex

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Flucloxacillin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body needs for energy production and healthy cells, is obtained mostly from food rather than from bacteria living in your gut. Flucloxacillin, like other antibiotics, can disrupt those gut bacteria, which do produce a small amount of riboflavin, but that bacterial contribution appears to be too minor to matter much in practice. The evidence rates this as insignificant, meaning a supplement is not something most people taking this antibiotic need to worry about. That said, if you have questions about your diet or are on a longer course, your pharmacist is always happy to talk it through.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Flucloxacillin →

Fosfomycin

Insignificant Depletion

Brand names include Monurol

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Fosfomycin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses to turn food into energy and keep skin and nerves healthy, can technically dip when you take antibiotics like fosfomycin. The reason is that antibiotics can disrupt the friendly bacteria living in your gut, and those bacteria do produce a small amount of riboflavin. That said, this bacterial contribution is pretty minor compared to what you get from food, so the effect is considered insignificant for most people. No riboflavin supplement is generally needed during a short course of fosfomycin, but if you have questions, your pharmacist is always a good person to ask.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Fosfomycin →

Furazolidone

Insignificant Depletion

Brand names include Furoxone

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Furazolidone? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, the B vitamin your body uses to turn food into energy and keep skin and eyes healthy, could theoretically dip a little while taking furazolidone. As an antibiotic, furazolidone can disrupt the bacteria living in your gut, and those bacteria do produce some riboflavin. The catch is that bacterial production contributes very little to your overall riboflavin supply since most of it simply comes from food. Given the insignificant rating here, a riboflavin supplement is not something most people need to think about while on this medication.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Furazolidone →

Gatifloxacin

Insignificant Depletion

Brand names include Tequin, Tequin Injection

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Gatifloxacin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses for energy production and healthy cell function, is obtained mostly from the foods you eat rather than from bacteria living in your gut. Gatifloxacin, like other antibiotics, can disrupt those gut bacteria, which do produce a small amount of riboflavin, but that contribution appears to be too minor to matter in a real-world sense. For most people taking this antibiotic, this is not a concern worth acting on, and a riboflavin supplement is not something you would typically need. If you have questions specific to your situation, your pharmacist is always a good person to ask.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Gatifloxacin →

Gemifloxacin

Insignificant Depletion

Brand names include Factive

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Gemifloxacin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to convert food into energy and keep your skin and nerves healthy, may technically dip a little when you take an antibiotic like gemifloxacin. The thinking is that antibiotics can disrupt the friendly bacteria in your gut that produce small amounts of riboflavin, but here is the reassuring part: your gut bacteria contribute very little to your overall riboflavin supply anyway, since most of it comes straight from the foods you eat. This interaction is rated insignificant, so for the short course most people take gemifloxacin, there is nothing extra you need to do.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Gemifloxacin →

Gentamicin (IV)

Insignificant Depletion

Brand names include Garamycin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Gentamicin (IV)? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps skin, eyes, and nerves working properly. Gentamicin, like other antibiotics, can alter the natural bacteria living in your gut, and those bacteria do produce a small amount of riboflavin. That said, your body gets the vast majority of riboflavin from the food you eat, so this bacterial change is unlikely to matter much in practice. The evidence rates this as insignificant, meaning most patients receiving gentamicin do not need a riboflavin supplement, but feel free to mention it to your pharmacist or doctor if you have concerns.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Gentamicin (IV) →

Grepafloxacin

Insignificant Depletion

Brand names include Raxar

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Grepafloxacin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses for energy production and keeping skin and nerves healthy, can theoretically dip a little when you take an antibiotic like grepafloxacin. The thinking is that antibiotics can disrupt the natural bacteria living in your gut, and those bacteria do produce some riboflavin. That said, most of what your body needs comes from food, not gut bacteria, so this effect is considered insignificant in practice. For most people taking grepafloxacin, no extra riboflavin is needed, but feel free to mention it to your pharmacist if you have concerns.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Grepafloxacin →

Imipenem, Cilastatin

Insignificant Depletion

Brand names include Primaxin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Imipenem, Cilastatin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses for energy production and keeping skin, eyes, and nerves healthy. With imipenem/cilastatin, the concern is that antibiotics can disrupt the natural bacteria living in your gut, and those bacteria do produce a small amount of riboflavin. That said, your gut flora contribute very little to your overall riboflavin supply since you get the vast majority from food. This connection is rated insignificant, so most people taking this antibiotic do not need a supplement, though you are always welcome to check with your pharmacist if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Imipenem, Cilastatin →

Imipenem, Cilastatin, Relebactam

Insignificant Depletion

Brand names include Recarbrio

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Imipenem, Cilastatin, Relebactam? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body counts on for turning food into energy and keeping your skin and nerves healthy. With antibiotics like this one, there is a theory that disrupting the natural bacteria in your gut could trim the small amount of riboflavin those bacteria produce, but here is the reassuring part: your gut bacteria contribute very little to your riboflavin supply anyway, since most of it comes straight from the food you eat. The evidence rates this as insignificant, so for most people taking this antibiotic, no extra riboflavin is needed.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Imipenem, Cilastatin, Relebactam →

Imipramine

Insignificant Depletion

Brand names include Tofranil, Tofranil PM

TCAs might reduce active riboflavin levels; however, this is not likely to be clinically significant.
TCAs have structural similarities to riboflavin and can interfere with its conversion to the active form flavin adenine dinucleotide (FAD). In animal models, very high doses of amitriptyline and imipramine (50 mg/kg daily) decrease FAD levels in the liver, heart, and brain. Lower doses (10 mg/kg daily) only affect levels in the heart. Since these doses are higher than those used therapeutically in humans, it is unlikely that the effect is clinically significant or that supplements are necessary.
Taking Imipramine? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin is a B vitamin your body needs to produce energy and keep cells working properly. Imipramine shares a similar chemical shape to riboflavin, and there is some evidence it can interfere with how the body converts riboflavin into its active, usable form. That said, this effect has really only been seen in animal studies using doses far higher than what people actually take, so for most patients this is considered insignificant. No action is needed for the vast majority of people, but if you have questions about your nutrition while on imipramine, your pharmacist or doctor is a good place to start.

References (2)
  1. Pinto J, Huang YP, Rivlin RS. Inhibition of riboflavin metabolism in rat tissues by chlorpromazine, imipramine and amitriptyline. J Clin Invest 1981;67:1500-6. PubMed
  2. Pinto J, Huang YP, Pelliccione N, Rivlin RS. Cardiac sensitivity to the inhibitory effects of chlorpromazine, imipramine, and amitriptyline upon formation of flavins. Biochem Pharmacol 1982;31:3495-9.. PubMed

Full nutrient report for Imipramine →

Isoniazid, Rifampin

Insignificant Depletion

Brand names include Rifamate

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Isoniazid, Rifampin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses for energy production and keeping skin and nerves healthy, is mostly absorbed from the foods you eat rather than made by gut bacteria. When antibiotics like isoniazid and rifampin alter the normal bacteria living in your gut, that bacterial source of riboflavin can drop a little, but since diet is the real supplier, this rarely adds up to anything meaningful. The evidence rates this as insignificant for most people, so a riboflavin supplement is generally not needed during this therapy. That said, if you have questions about your nutrition while on these medications, your pharmacist or doctor is a good place to start.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Isoniazid, Rifampin →

Kanamycin

Insignificant Depletion

Brand names include Kantrex

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Kanamycin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to turn food into energy and keep skin and nerves healthy, is mainly absorbed from the foods you eat rather than made by gut bacteria. Kanamycin, like other antibiotics, can disrupt the bacteria living in your gut, and those bacteria do produce a small amount of riboflavin. In practice, though, that bacterial contribution is so modest that losing it does not appear to matter much for most people. This one is rated insignificant, so a riboflavin supplement is generally not needed, but feel free to mention it to your pharmacist if you have concerns.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Kanamycin →

Brand names include Prevpac

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Lansoprazole, Amoxicillin, Clarithromycin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body needs to turn food into energy and keep your skin and nerves healthy. When antibiotics like amoxicillin and clarithromycin are used, they can disrupt the friendly bacteria living in your gut, and those bacteria normally make a small amount of riboflavin. That said, your body gets the vast majority of its riboflavin from the food you eat, so this bacterial disruption is considered insignificant for most people. No riboflavin supplement is typically needed during this antibiotic therapy, but if you have questions about your diet or nutrient intake, your pharmacist or doctor is a great person to ask.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Lansoprazole, Amoxicillin, Clarithromycin →

Lefamulin Acetate

Insignificant Depletion

Brand names include Xenleta

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Lefamulin Acetate? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, sometimes called vitamin B2, is something your body counts on for turning food into usable energy and keeping your skin and tissues healthy. Lefamulin is an antibiotic, and like other antibiotics, it can affect the bacteria that normally live in your gut, which produce small amounts of riboflavin. That said, most of what your body needs comes from food anyway, so this effect is considered insignificant for most people taking this medication. No riboflavin supplement is generally needed during a course of lefamulin, but if you have questions about your diet or nutrition, your pharmacist or doctor is a good person to ask.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Lefamulin Acetate →

Levofloxacin

Insignificant Depletion

Brand names include Levaquin, Levaquin Injection, Leva-pak

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Levofloxacin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin, eyes, and nerves working properly. Levofloxacin, like other antibiotics, can disrupt the natural bacteria living in your gut, and those bacteria do make a small amount of riboflavin. That said, most of what your body needs comes from food, not gut bacteria, so this is considered an insignificant effect. Most people taking levofloxacin do not need to take a riboflavin supplement, but if you have questions, your pharmacist is happy to talk it through.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Levofloxacin →

Levofloxacin (ophthalmic)

Insignificant Depletion

Brand names include Levofloxacin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Levofloxacin (ophthalmic)? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to convert food into energy and keep your skin, eyes, and nervous system working properly. In theory, antibiotics can nudge riboflavin levels down slightly by disrupting the gut bacteria that produce a small amount of it, but the bulk of what you need comes from food, not from bacteria. With levofloxacin eye drops in particular, the amount absorbed into your body is minimal, making this even less of a concern. The evidence rates this as insignificant, so most people using this medication do not need to think about riboflavin supplementation at all.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Levofloxacin (ophthalmic) →

Lincomycin HCl

Insignificant Depletion

Brand names include Lincocin, Lincorex

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Lincomycin HCl? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to turn food into energy and keep skin and nerves healthy, is mostly absorbed from the food you eat rather than from gut bacteria. Lincomycin is an antibiotic, and like other antibiotics it can disrupt the natural bacteria living in your intestines that make small amounts of riboflavin. That said, since dietary sources do the heavy lifting here, this disruption is considered insignificant for most people. No riboflavin supplement is generally needed while taking this medication, though your pharmacist is always a good person to check with if you have specific concerns.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Lincomycin HCl →

Linezolid

Insignificant Depletion

Brand names include Zyvox, Zyvox Injection

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Linezolid? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body turn food into energy and keeps your skin and nerves healthy. Linezolid is an antibiotic, and antibiotics can disrupt the natural bacteria living in your gut, which normally produce small amounts of riboflavin. That said, your body gets the vast majority of riboflavin from food, not gut bacteria, so this interaction is rated insignificant. Most people taking linezolid do not need a riboflavin supplement, but feel free to mention it to your pharmacist if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Linezolid →

Lofepramine

Insignificant Depletion

Brand names include Feprapax, Lomont, Gamanil

TCAs might reduce active riboflavin levels; however, this is not likely to be clinically significant.
TCAs have structural similarities to riboflavin and can interfere with its conversion to the active form flavin adenine dinucleotide (FAD). In animal models, very high doses of amitriptyline and imipramine (50 mg/kg daily) decrease FAD levels in the liver, heart, and brain. Lower doses (10 mg/kg daily) only affect levels in the heart. Since these doses are higher than those used therapeutically in humans, it is unlikely that the effect is clinically significant or that supplements are necessary.
Taking Lofepramine? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your cells working properly. Lofepramine belongs to a class of antidepressants that share a chemical shape similar to riboflavin, and there is some evidence they can interfere with the step that turns riboflavin into its active, usable form in the body. That said, this effect has mainly been seen in animal studies using doses far higher than what people actually take, so the concern is considered insignificant for most patients. No action is needed for the majority of people, but if you have questions about your nutrition while on this medication, your pharmacist or doctor is a great place to start.

References (2)
  1. Pinto J, Huang YP, Rivlin RS. Inhibition of riboflavin metabolism in rat tissues by chlorpromazine, imipramine and amitriptyline. J Clin Invest 1981;67:1500-6. PubMed
  2. Pinto J, Huang YP, Pelliccione N, Rivlin RS. Cardiac sensitivity to the inhibitory effects of chlorpromazine, imipramine, and amitriptyline upon formation of flavins. Biochem Pharmacol 1982;31:3495-9.. PubMed

Full nutrient report for Lofepramine →

Lomefloxacin

Insignificant Depletion

Brand names include Maxaquin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Lomefloxacin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to convert food into energy and keep your skin, eyes, and nervous system healthy. Lomefloxacin, like other antibiotics, can disrupt the bacteria that normally live in your gut, and those bacteria do produce small amounts of riboflavin. That said, your gut bacteria contribute very little to your overall riboflavin supply since most of it comes straight from the foods you eat. For the vast majority of people taking this antibiotic, no extra riboflavin is needed, but feel free to mention it to your pharmacist if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Lomefloxacin →

Loracarbef

Insignificant Depletion

Brand names include Lorabid

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Loracarbef? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin and nervous system healthy. Loracarbef, like other antibiotics, can disrupt the friendly bacteria living in your gut, and those bacteria do produce a small amount of riboflavin. That said, because your body gets the vast majority of its riboflavin from the food you eat, this disruption is considered insignificant for most people. No supplement is needed for a typical course of this antibiotic, but ask your pharmacist if you have questions about your diet or nutrition.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Loracarbef →

Meropenem

Insignificant Depletion

Brand names include Merrem IV

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Meropenem? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to convert food into energy and keep skin and nerves healthy, is mainly absorbed from what you eat rather than produced by gut bacteria. Meropenem, like other antibiotics, can disrupt those bacteria, which do make a small amount of riboflavin on their own, but that bacterial contribution is considered minor enough that your overall riboflavin levels are unlikely to drop in any meaningful way. For most people, this is a reassuring non-issue, and extra riboflavin is not considered necessary during a course of this antibiotic.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Meropenem →

Meropenem, Vaborbactam

Insignificant Depletion

Brand names include Vabomere

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Meropenem, Vaborbactam? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses for energy production and keeping skin and nerves healthy, is mainly supplied through the foods you eat rather than from bacteria living in your gut. Meropenem with vaborbactam is an antibiotic, and antibiotics can disrupt those gut bacteria, which do produce a small amount of riboflavin on their own. That said, because diet is your real source of this vitamin, losing that tiny bacterial contribution is not considered meaningful. The evidence rates this as insignificant, so most patients do not need a riboflavin supplement during this treatment.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Meropenem, Vaborbactam →

Methacycline

Insignificant Depletion

Brand names include Rondomycin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Methacycline? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to turn food into energy and keep skin and eyes healthy, is mainly absorbed from the foods you eat rather than made by gut bacteria. Methacycline, like other antibiotics, can disrupt the normal bacteria living in your intestines, and those bacteria do produce a small amount of riboflavin. That said, since your diet does most of the heavy lifting here, this disruption is not considered clinically meaningful for most people. No riboflavin supplement is typically needed while taking this antibiotic, but if you have questions about your specific situation, your pharmacist or doctor is a great place to start.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Methacycline →

Methenamine Hippurate

Insignificant Depletion

Brand names include Urex, Hiprex

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Methenamine Hippurate? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses for energy production and keeping skin, eyes, and nerves healthy. Methenamine hippurate is an antibiotic, and like other antibiotics it can affect the friendly bacteria living in your gut that normally make a small amount of riboflavin on their own. That said, most of the riboflavin your body needs comes from the food you eat, not from gut bacteria, so this effect is considered insignificant for most people. No riboflavin supplement is typically needed while taking this medication, but feel free to mention it to your pharmacist if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Methenamine Hippurate →

Methenamine Mandelate

Insignificant Depletion

Brand names include Mandelamine, Methimazole

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Methenamine Mandelate? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses to convert food into energy and keep skin and tissues healthy, may technically dip a little when you take methenamine mandelate because antibiotics can reduce the bacteria in your gut that produce small amounts of it. That said, your gut bacteria aren't really your main source of riboflavin anyway since you get the bulk of it from food, so this is considered an insignificant depletion. For most people on this medication, there is nothing extra to do, but if you have questions about your diet or whether a supplement makes sense for you personally, your pharmacist or doctor is a good person to ask.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Methenamine Mandelate →

Brand names include Thiacide

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Methenamine Mandelate, Potassium Acid Phosphate? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin and nervous system healthy. This medication can alter the natural bacteria living in your gut, and those bacteria do produce a small amount of riboflavin. That said, your body gets the vast majority of its riboflavin from what you eat, so this interaction is considered insignificant for most people. No supplement is typically needed, but if you have questions about your diet or nutrition while on this medication, your pharmacist or doctor is a good person to ask.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Methenamine Mandelate, Potassium Acid Phosphate →

Brand names include Uroquid-Acid No. 2

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Methenamine Mandelate, Sodium Acid Phosphate? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin and nerves healthy. This antibiotic combination may slightly reduce the amount of riboflavin that gut bacteria produce, but here is the reassuring part: your body gets the vast majority of its riboflavin from the food you eat, not from bacteria in your gut. The evidence rates this as insignificant, so most people taking this medication do not need to add a supplement. If you have any concerns, your pharmacist or doctor is a great person to ask.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Methenamine Mandelate, Sodium Acid Phosphate →

Brand names include Prosed DS

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Methenamine, Phenyl Salicylate, Methylene Blue? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body turn food into energy and keeps your skin and tissues healthy. This combination product contains an antibiotic component that may slightly reduce the amount of riboflavin bacteria in your gut would normally produce, but here is the reassuring part: your gut bacteria contribute very little to your riboflavin supply anyway, since most of it comes from food. For the vast majority of people taking this medication, no riboflavin supplement is needed, though your pharmacist or doctor can always answer questions about your specific situation.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Methenamine, Phenyl Salicylate, Methylene Blue →

Methenamine, Sodium Biphosphate

Insignificant Depletion

Brand names include Uro-Phosphate

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Methenamine, Sodium Biphosphate? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body turn food into energy and keeps your skin, eyes, and nerves working well. Methenamine with sodium biphosphate is an antibiotic urinary medication, and like other antibiotics it can slightly reduce the bacteria in your gut that normally make small amounts of riboflavin. That said, your gut bacteria contribute very little to your riboflavin supply compared to what you get from food, so this is rated as insignificant. Most people taking this medication have nothing to worry about on this front, and a riboflavin supplement is not needed for typical use.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Methenamine, Sodium Biphosphate →

Metronidazole

Insignificant Depletion

Brand names include Flagyl, Protostat, Nidazol

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Metronidazole? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to convert food into energy and support healthy cells, is mainly absorbed from the foods you eat rather than made by gut bacteria. Metronidazole can disrupt the normal bacteria living in your intestines, and those bacteria do produce a small amount of riboflavin, but research suggests that contribution is too minor to matter much. For most people taking this antibiotic, this is considered an insignificant concern and no riboflavin supplement is needed. That said, if you have questions about your diet or any symptoms you notice while taking metronidazole, your pharmacist or doctor is the right person to ask.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Metronidazole →

Brand names include Pylera

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Metronidazole, Tetracyline, Bismuth Subcitrate Potassium? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin, eyes, and nerves working well. This antibiotic combination can affect the natural bacteria living in your gut, and those bacteria do produce a small amount of riboflavin. The key word is 'small': your body gets the vast majority of its riboflavin from the food you eat, so this interaction is considered insignificant for most people. A riboflavin supplement is not something most patients need during this therapy, but if you have questions about your diet, your pharmacist is a great person to ask.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Metronidazole, Tetracyline, Bismuth Subcitrate Potassium →

Mezlocillin

Insignificant Depletion

Brand names include Mezlin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Mezlocillin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses for energy production and keeping skin and tissues healthy, can technically be affected by antibiotics like mezlocillin because these drugs disrupt the natural bacteria living in your gut, and those bacteria do produce small amounts of riboflavin. That said, your gut bacteria contribute very little to your overall riboflavin supply since you get the vast majority from food. The evidence rates this as insignificant, so most people taking mezlocillin have nothing to worry about and do not need a supplement. If you have questions about your diet or vitamin intake during antibiotic treatment, your pharmacist or doctor is a great place to start.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Mezlocillin →

Minocycline

Insignificant Depletion

Brand names include Vectrin, Dynacin, Minocin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Minocycline? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to convert food into energy and keep skin and tissues healthy, is mostly absorbed from the foods you eat rather than produced by gut bacteria. Minocycline, like other antibiotics, can disrupt the normal bacteria living in your intestines, and those bacteria do make small amounts of riboflavin. That said, since dietary sources are what really matter here, this effect is considered insignificant for most people. No riboflavin supplement is generally needed while taking minocycline, but if you have questions about your diet or any symptoms you notice, your pharmacist is a good first stop.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Minocycline →

Minocycline Hydrochloride

Insignificant Depletion

Brand names include Ximino, Minolira

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Minocycline Hydrochloride? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to convert food into energy and keep skin and nerves healthy. Minocycline, like other antibiotics, can affect the friendly bacteria living in your gut, and those bacteria do make a small amount of riboflavin. The thing is, your body gets the vast majority of its riboflavin from what you eat, so losing that tiny bacterial contribution is not considered meaningful. This is rated as an insignificant depletion, meaning most people taking minocycline do not need to worry about it or take a supplement, but feel free to mention it to your pharmacist if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Minocycline Hydrochloride →

Moxifloxacin

Insignificant Depletion

Brand names include Avelox

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Moxifloxacin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin and nervous system healthy. Like other antibiotics, moxifloxacin can affect the friendly bacteria living in your gut, and those bacteria do make small amounts of riboflavin. That said, most of what your body needs comes from food, not gut bacteria, so this effect is considered insignificant. For the average person taking a short course of moxifloxacin, no extra riboflavin is needed, but feel free to ask your pharmacist if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Moxifloxacin →

Nafcillin

Insignificant Depletion

Brand names include Nallpen

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Nafcillin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body turn food into energy and keeps your skin and nervous system healthy. Nafcillin, like other antibiotics, can reduce the friendly bacteria living in your gut that produce small amounts of riboflavin, though research suggests this bacterial contribution is minor since most of what your body needs comes from food anyway. For the vast majority of people taking nafcillin, this is not considered a meaningful concern and a riboflavin supplement is not something you would routinely need. If you have questions about your diet or nutritional needs during treatment, your pharmacist or doctor is a good person to ask.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Nafcillin →

Nafcillin Sodium

Insignificant Depletion

Brand names include Unipen

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Nafcillin Sodium? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses to turn food into energy and keep skin and eyes healthy, can theoretically dip a little when you take an antibiotic like nafcillin. The thinking is that antibiotics can disrupt the friendly bacteria living in your gut, and those bacteria do make small amounts of riboflavin. In practice, though, your diet supplies the vast majority of what your body needs, so this effect is considered insignificant for most people. No riboflavin supplement is needed during a course of nafcillin, but your pharmacist is always happy to answer questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Nafcillin Sodium →

Nalidixic Acid

Insignificant Depletion

Brand names include NegGram

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Nalidixic Acid? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses to convert food into energy and keep skin and tissues healthy, can theoretically dip when you take an antibiotic like nalidixic acid. The thinking is that antibiotics disrupt the friendly bacteria living in your gut, and those bacteria normally produce a small amount of riboflavin. That said, your gut bacteria contribute very little to your overall riboflavin supply compared to what you get from food, so this interaction is considered insignificant for most people. No supplement is needed, but feel free to mention it to your pharmacist if you have any concerns.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Nalidixic Acid →

Neomycin

Insignificant Depletion

Brand names include Mycifradin, Neo-Fradin, Myciguent

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Neomycin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to turn food into energy and keep skin and nerves healthy, is mostly absorbed from the food you eat rather than made by gut bacteria. Neomycin is an antibiotic, and like other antibiotics it can disrupt the normal bacteria living in your gut that produce small amounts of riboflavin. That said, because dietary sources do most of the work here, this disruption does not appear to make a meaningful dent in your riboflavin levels for most people. This one is rated insignificant, so there is no need to worry or reach for a supplement unless your pharmacist or doctor tells you otherwise.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Neomycin →

Netilmicin

Insignificant Depletion

Brand names include Netromycin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Netilmicin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to convert food into energy and keep your skin and tissues healthy. Netilmicin is an antibiotic, and antibiotics in general can disrupt the friendly bacteria in your gut that produce small amounts of riboflavin. That said, your body gets the vast majority of its riboflavin from the food you eat, not from gut bacteria, so this effect is considered insignificant for most people. No riboflavin supplement is typically needed, but if you have questions about your diet while on this medication, your pharmacist is a great person to ask.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Netilmicin →

Nitrofurantoin

Insignificant Depletion

Brand names include Macrodantin, Furadantin, Furatoin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Nitrofurantoin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses for energy production and healthy cell function, can theoretically dip a little when you take antibiotics like nitrofurantoin. The reason is that gut bacteria normally make small amounts of riboflavin, and antibiotics can disrupt those bacteria. That said, your body gets the vast majority of its riboflavin from food, so this disruption is considered insignificant for most people. No supplement is typically needed for a short course of nitrofurantoin, but if you have questions about your diet, your pharmacist is a great place to start.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Nitrofurantoin →

Norfloxacin

Insignificant Depletion

Brand names include Norflox, Noroxin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Norfloxacin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to convert food into energy and keep skin and nerves healthy, is mostly absorbed from the food you eat rather than made by gut bacteria. Norfloxacin, like other antibiotics, can disrupt the bacteria living in your gut, and those bacteria do produce a small amount of riboflavin. That said, because dietary intake is what really drives your riboflavin levels, this effect is considered insignificant for most people. No extra riboflavin supplement is needed for a typical course of this antibiotic, but if you have questions about your nutrition during treatment, your pharmacist or doctor is a great resource.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Norfloxacin →

Nortriptyline

Insignificant Depletion

Brand names include Pamelor, Aventyl, Allegron

TCAs might reduce active riboflavin levels; however, this is not likely to be clinically significant.
TCAs have structural similarities to riboflavin and can interfere with its conversion to the active form flavin adenine dinucleotide (FAD). In animal models, very high doses of amitriptyline and imipramine (50 mg/kg daily) decrease FAD levels in the liver, heart, and brain. Lower doses (10 mg/kg daily) only affect levels in the heart. Since these doses are higher than those used therapeutically in humans, it is unlikely that the effect is clinically significant or that supplements are necessary.
Taking Nortriptyline? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to convert food into energy and keep cells working properly. Nortriptyline belongs to a drug class whose chemical structure is similar enough to riboflavin that it may interfere with the step that turns riboflavin into its active, usable form in the body. That said, this effect has really only shown up in animal studies using doses far higher than what people actually take, so for most patients this is considered insignificant and no supplement is needed. If you have any concerns, a quick conversation with your pharmacist is always a good place to start.

References (2)
  1. Pinto J, Huang YP, Rivlin RS. Inhibition of riboflavin metabolism in rat tissues by chlorpromazine, imipramine and amitriptyline. J Clin Invest 1981;67:1500-6. PubMed
  2. Pinto J, Huang YP, Pelliccione N, Rivlin RS. Cardiac sensitivity to the inhibitory effects of chlorpromazine, imipramine, and amitriptyline upon formation of flavins. Biochem Pharmacol 1982;31:3495-9.. PubMed

Full nutrient report for Nortriptyline →

Ofloxacin

Insignificant Depletion

Brand names include Oflox, Floxin, Floxin Injection

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Ofloxacin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to turn food into energy and keep your skin and nerves healthy. Ofloxacin, like other antibiotics, can disrupt the friendly bacteria that live in your gut, and those bacteria do produce small amounts of riboflavin. The key word, though, is small: your diet does most of the heavy lifting for riboflavin, so this interaction is considered insignificant for the vast majority of people. No extra supplement is typically needed, but feel free to mention it to your pharmacist if you have any concerns.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Ofloxacin →

Oritavancin Diphosphate

Insignificant Depletion

Brand names include Orbactiv, Kimyrsa

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Oritavancin Diphosphate? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body turn food into energy and keeps your skin, nerves, and eyes working well. Oritavancin is an antibiotic, and antibiotics can sometimes lower riboflavin by disrupting the friendly bacteria in your gut that produce small amounts of it. That said, your body gets most of its riboflavin from food rather than gut bacteria, so this effect is considered insignificant for most patients. No supplement is needed, but feel free to mention it to your pharmacist if you have any concerns.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Oritavancin Diphosphate →

Oxacillin

Insignificant Depletion

Brand names include Prostaphlin, Bactocill

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Oxacillin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to turn food into energy and keep your skin, eyes, and nerves healthy. Because oxacillin is an antibiotic, it can disrupt the normal bacteria living in your gut, and those bacteria do produce a small amount of riboflavin. That said, your gut bacteria contribute very little to your overall riboflavin supply since most of it comes straight from the foods you eat. This is rated as an insignificant depletion, so for most people taking oxacillin, no supplement is needed. Just eat a balanced diet and check in with your pharmacist or doctor if you have any concerns.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Oxacillin →

Oxytetracycline

Insignificant Depletion

Brand names include Terramycin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Oxytetracycline? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses for energy production and keeping skin, eyes, and nerves healthy. Oxytetracycline, like other antibiotics, can disrupt the friendly bacteria living in your gut, and those bacteria do produce a small amount of riboflavin. The thing is, your gut bacteria contribute very little to your overall riboflavin supply compared to what you get from food, so this interaction is considered insignificant for most people. No supplement is typically needed, but if you have questions about your diet while on this antibiotic, your pharmacist is a good place to start.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Oxytetracycline →

Brand names include Urobiotic

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Oxytetracycline, Phenazopyridine, Sulfamethizole? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses for energy production and healthy cell function, gets most of its supply from the food you eat rather than from bacteria living in your gut. These antibiotics can disrupt those gut bacteria, which do produce a small amount of riboflavin, but that contribution is considered too minor to make a real difference. For most people taking this combination, riboflavin levels are not a practical concern. No extra supplementation is typically needed, though your pharmacist is always happy to answer questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Oxytetracycline, Phenazopyridine, Sulfamethizole →

Ozenoxacin

Insignificant Depletion

Brand names include Xepi

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Ozenoxacin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses for energy production and healthy cell function, comes mostly from the foods you eat rather than from bacteria living in your gut. Ozenoxacin is a topical antibiotic, and like other antibiotics, it has been loosely linked to small changes in gut bacterial activity that could, in theory, nudge riboflavin levels slightly. In practice, this effect is considered insignificant, and a riboflavin supplement is not something most people using this medication need to worry about. If you have broader concerns about your nutrition while on any antibiotic, a quick chat with your pharmacist is always a good idea.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Ozenoxacin →

Paromomycin Sulfate

Insignificant Depletion

Brand names include Humatin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Paromomycin Sulfate? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to convert food into energy and keep skin, eyes, and nerves working well. Paromomycin, like other antibiotics, can alter the natural bacteria living in your gut, and those bacteria normally make small amounts of riboflavin. In practice though, your body gets the vast majority of its riboflavin from food rather than from gut bacteria, so this effect is considered insignificant for most people. No supplement is needed for this one, but feel free to mention it to your pharmacist if you have any concerns.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Paromomycin Sulfate →

Penicillin G

Insignificant Depletion

Brand names include Pfizerpen

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Penicillin G? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to convert food into energy and keep your skin, eyes, and nerves working well. Penicillin G, like other antibiotics, can disrupt the natural bacteria living in your gut, and those bacteria do produce small amounts of riboflavin. Even so, the evidence rates this as insignificant because your body gets the vast majority of riboflavin from food, not from gut bacteria. Most people taking Penicillin G have nothing to worry about here, and routine supplementation is not considered necessary.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Penicillin G →

Penicillin G Benzathine

Insignificant Depletion

Brand names include Bicillin L-A, Permapen

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Penicillin G Benzathine? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin and nervous system working properly. Penicillin G Benzathine, like other antibiotics, can affect the natural bacteria living in your gut, and those bacteria do produce a small amount of riboflavin. That said, your body gets the vast majority of riboflavin from food, not from gut bacteria, so this effect is considered insignificant for most people. No extra supplement is needed, but if you have questions about your diet while on this antibiotic, your pharmacist is a good place to start.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Penicillin G Benzathine →

Penicillin G Benzathine, Procaine

Insignificant Depletion

Brand names include Bicillin C-R

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Penicillin G Benzathine, Procaine? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses for energy production and healthy skin and eyes, is mostly absorbed from the food you eat rather than made by gut bacteria. Penicillin G Benzathine/Procaine can disrupt the normal bacteria living in your intestines, which slightly reduces the small amount of riboflavin those bacteria produce. Because your diet is your main source anyway, this disruption is considered insignificant for most people. No riboflavin supplement is generally needed while taking this antibiotic, but if you have questions about your nutrition during treatment, your pharmacist or doctor is a good resource.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Penicillin G Benzathine, Procaine →

Penicillin G Potassium

Insignificant Depletion

Brand names include Pentids, Pentids 400, Pentids 800

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Penicillin G Potassium? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to convert food into energy and keep skin and nerves healthy, can theoretically dip a little when you take penicillin G potassium. The thinking is that antibiotics can disrupt the helpful bacteria living in your gut, and those bacteria normally produce small amounts of riboflavin on their own. In practice, though, your gut bacteria contribute very little to your overall riboflavin supply compared to what you get from food, so this is considered an insignificant concern for most people. No riboflavin supplement is needed during a course of this antibiotic, but if you have questions specific to your situation, your pharmacist is always a good starting point.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Penicillin G Potassium →

Penicillin G, Procaine

Insignificant Depletion

Brand names include Penicillin G Procaine

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Penicillin G, Procaine? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses to convert food into energy and keep skin and tissues healthy, is mostly absorbed from what you eat rather than from bacteria living in your gut. Procaine penicillin G can disrupt those gut bacteria, which do produce a small amount of riboflavin, but research suggests that contribution is too minor to make a real difference to your levels. This interaction is rated insignificant, so for most people taking this antibiotic a riboflavin supplement simply is not necessary. If you have concerns, your pharmacist or doctor can give you personalized guidance.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Penicillin G, Procaine →

Penicillin V

Insignificant Depletion

Brand names include Pen-Vee

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Penicillin V? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body turn food into energy and keeps your skin, eyes, and nerves healthy. Penicillin V, like other antibiotics, can disrupt the bacteria that normally live in your gut, and those bacteria do produce a small amount of riboflavin. That said, your body gets the vast majority of riboflavin from the food you eat, so this bacterial disruption is considered insignificant for most people. No riboflavin supplement is needed during a course of Penicillin V, but feel free to ask your pharmacist if you have concerns.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Penicillin V →

Penicillin V Potassium

Insignificant Depletion

Brand names include V-Cillin K, Veetids, Pen VK

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Penicillin V Potassium? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to convert food into energy and keep skin and nerves healthy, is normally supplied through what you eat rather than through bacteria living in your gut. Penicillin V can disrupt those gut bacteria, and there is some thought that this might nudge riboflavin levels slightly lower as a result. In practice, though, this effect is considered insignificant, meaning the vast majority of people taking a course of this antibiotic do not need a supplement. Just keep eating a balanced diet, and if you have any concerns, your pharmacist or doctor is a good person to ask.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Penicillin V Potassium →

Penicillin VK

Insignificant Depletion

Brand names include Robicillin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Penicillin VK? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to convert food into energy and keep your skin, eyes, and nerves working well. Penicillin VK is an antibiotic, and antibiotics can disrupt the friendly bacteria living in your gut that normally produce small amounts of riboflavin. That said, those bacteria contribute very little to your overall supply, since most riboflavin comes straight from the food you eat. The evidence rates this as insignificant, so for most people taking a short course of Penicillin VK, there is nothing extra to worry about here.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Penicillin VK →

Pentamidine

Insignificant Depletion

Brand names include Pentam 300

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Pentamidine? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body depends on for turning food into energy and keeping your skin and nervous system healthy. Pentamidine, like other antibiotic-class medications, may slightly affect the bacteria in your gut that produce small amounts of riboflavin, but here is the reassuring part: your body gets nearly all its riboflavin from food anyway, so that bacterial contribution does not matter much. The evidence rates this as insignificant, meaning most people taking pentamidine have no reason to add a riboflavin supplement. If you still have questions about your nutritional needs while on this medication, a quick word with your pharmacist or doctor is always a good idea.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Pentamidine →

Phenazopyridine, Sulfamethizole

Insignificant Depletion

Brand names include Thiosulfil-A, Thiosulfil-A Forte

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Phenazopyridine, Sulfamethizole? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin and tissues healthy. Sulfamethizole, the antibiotic in this combination, can alter the natural bacteria living in your gut, and those bacteria do produce a small amount of riboflavin. That said, most of the riboflavin your body needs comes from the food you eat, not from gut bacteria, so this effect is considered insignificant for most people. No extra riboflavin is typically needed during a short course of this medication, but feel free to mention it to your pharmacist if you have any concerns.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Phenazopyridine, Sulfamethizole →

Phenazopyridine, Sulfisoxazole

Insignificant Depletion

Brand names include Azo-Gantrisin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Phenazopyridine, Sulfisoxazole? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses for energy production and healthy cell function, is obtained mainly from the foods you eat rather than from bacteria living in your gut. Sulfisoxazole, the antibiotic in this combination, can disrupt those gut bacteria, which do produce a small amount of riboflavin, but that bacterial contribution is considered minor. Because of that, this interaction is rated as insignificant for most people, meaning a riboflavin supplement is generally not needed during a short course of this medication. If you have specific concerns, your pharmacist is always a good starting point.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Phenazopyridine, Sulfisoxazole →

Piperacillin

Insignificant Depletion

Brand names include Pipracil

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Piperacillin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, the B vitamin your body uses to turn food into energy and keep skin and eyes healthy, can theoretically dip a little when you take an antibiotic like piperacillin. The thinking is that antibiotics disrupt the friendly bacteria living in your gut, and those bacteria normally produce small amounts of riboflavin. That said, your gut bacteria contribute very little to your overall riboflavin supply since most of it comes straight from the food you eat. The evidence rates this as insignificant, so for most people taking piperacillin, no extra riboflavin is needed.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Piperacillin →

Piperacillin , Tazobactam

Insignificant Depletion

Brand names include Zosyn

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Piperacillin , Tazobactam? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body turn food into energy and keeps your skin and nerves healthy. Piperacillin/tazobactam is a broad-spectrum antibiotic, and like other antibiotics it can disrupt the natural bacteria living in your gut. Those bacteria do produce a small amount of riboflavin, but your body gets the vast majority of it from the food you eat, so losing that bacterial contribution rarely matters. The evidence rates this as insignificant, meaning most patients on this antibiotic have nothing to worry about and do not need a riboflavin supplement.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Piperacillin , Tazobactam →

Pivampicillin

Insignificant Depletion

Brand names include Pondicillin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Pivampicillin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to convert food into energy and keep skin and nerves healthy, is mainly absorbed from what you eat rather than from bacteria living in your gut. Pivampicillin, like other antibiotics, can disrupt those gut bacteria and reduce the small amount of riboflavin they produce, but that bacterial contribution is quite minor to begin with. The evidence rates this as insignificant, meaning most people taking pivampicillin have nothing to worry about here and do not need a supplement. As always, if you have questions about your nutrition during antibiotic treatment, your pharmacist or doctor is a good person to ask.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Pivampicillin →

Pivmecillinam

Insignificant Depletion

Brand names include Selexid

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Pivmecillinam? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses for energy production and keeping skin and nerves healthy, may dip slightly when you take pivmecillinam because antibiotics can disrupt the friendly bacteria in your gut that produce small amounts of it. That said, your gut bacteria contribute very little to your riboflavin supply anyway since most of it comes straight from the foods you eat. This interaction is rated as insignificant, so for the vast majority of people taking this antibiotic, no extra riboflavin is needed. If you have concerns or eat a very limited diet, a quick conversation with your pharmacist can put your mind at ease.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Pivmecillinam →

Plazomicin Sulfate

Insignificant Depletion

Brand names include Zemdri

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Plazomicin Sulfate? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin, eyes, and nerves working properly. Plazomicin is an antibiotic, and antibiotics can slightly shift the balance of bacteria living in your gut, which normally produce a small amount of riboflavin on their own. That said, most of what your body uses comes from food rather than gut bacteria, so this effect is considered insignificant for most people. No riboflavin supplement is needed during treatment, but feel free to mention it to your pharmacist if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Plazomicin Sulfate →

Pretomanid

Insignificant Depletion
Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Pretomanid? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body turn food into energy and keeps your skin, eyes, and nerves working properly. Pretomanid is an antibiotic, and antibiotics in general can slightly shift the balance of bacteria living in your gut, which normally produce small amounts of riboflavin as a byproduct. That said, your body gets the vast majority of its riboflavin from food rather than from gut bacteria, so this effect is considered insignificant for most people. No riboflavin supplement is needed, but if you have questions your pharmacist is always a good first stop.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Pretomanid →

Protriptyline

Insignificant Depletion

Brand names include Vivactil

TCAs might reduce active riboflavin levels; however, this is not likely to be clinically significant.
TCAs have structural similarities to riboflavin and can interfere with its conversion to the active form flavin adenine dinucleotide (FAD). In animal models, very high doses of amitriptyline and imipramine (50 mg/kg daily) decrease FAD levels in the liver, heart, and brain. Lower doses (10 mg/kg daily) only affect levels in the heart. Since these doses are higher than those used therapeutically in humans, it is unlikely that the effect is clinically significant or that supplements are necessary.
Taking Protriptyline? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin is a B vitamin your body needs to convert food into energy and keep cells running properly. Protriptyline belongs to a drug class whose chemical structure is similar enough to riboflavin that it may slightly interfere with the step that turns riboflavin into its active, working form inside the body. That said, the research pointing to this effect used doses far higher than anything prescribed to people, so for most patients this is considered insignificant and no supplement is typically needed. If you have any concerns, a quick conversation with your pharmacist or doctor can put your mind at ease.

References (2)
  1. Pinto J, Huang YP, Rivlin RS. Inhibition of riboflavin metabolism in rat tissues by chlorpromazine, imipramine and amitriptyline. J Clin Invest 1981;67:1500-6. PubMed
  2. Pinto J, Huang YP, Pelliccione N, Rivlin RS. Cardiac sensitivity to the inhibitory effects of chlorpromazine, imipramine, and amitriptyline upon formation of flavins. Biochem Pharmacol 1982;31:3495-9.. PubMed

Full nutrient report for Protriptyline →

Pyrazinamide

Insignificant Depletion

Brand names include Tebrazid

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Pyrazinamide? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to turn food into energy and keep cells working properly. Pyrazinamide is an antibiotic, and like other antibiotics it can disrupt the helpful bacteria that normally live in your gut, some of which produce small amounts of riboflavin. That said, most of what your body needs comes from food, not gut bacteria, so this effect is considered insignificant for most people. Riboflavin supplements are generally not needed while taking this medication, but feel free to mention it to your pharmacist or doctor if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Pyrazinamide →

Quinupristin, Dalfopristin

Insignificant Depletion

Brand names include Synercid

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Quinupristin, Dalfopristin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is a nutrient your body uses to convert food into energy and keep skin, nerves, and red blood cells healthy. Quinupristin and dalfopristin are antibiotics, and like other antibiotics they can disrupt the normal bacteria living in your gut, which do produce a small amount of riboflavin. That said, your gut bacteria contribute very little to your overall riboflavin supply since most of it comes straight from the food you eat, so any drop caused by this antibiotic is considered insignificant. For most patients, no extra riboflavin is needed, but feel free to mention it to your pharmacist if you have concerns.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Quinupristin, Dalfopristin →

Retapamulin

Insignificant Depletion

Brand names include Altabax, Altargo

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Retapamulin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to convert food into energy and keep skin and nerves healthy, is normally absorbed from the food you eat rather than produced by your body. Retapamulin is a topical antibiotic, and like other antibiotics it could theoretically affect the gut bacteria that make small amounts of riboflavin, but those bacteria contribute very little to your overall supply anyway. For most people using retapamulin, this is considered insignificant and no supplement is needed. If you have questions about your nutrition during antibiotic therapy, your pharmacist is always a good place to start.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Retapamulin →

Rifabutin

Insignificant Depletion

Brand names include Mycobutin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Rifabutin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to convert food into energy and keep skin and nerves healthy, can in theory be affected by rifabutin and other antibiotics because these drugs alter the normal bacteria living in your gut, and those bacteria do produce a small amount of riboflavin. That said, your gut flora contribute very little to your overall riboflavin supply since most of it comes straight from the foods you eat. This interaction is rated insignificant, so for most people taking rifabutin, no extra riboflavin is needed. If you still have questions or concerns, a quick chat with your pharmacist can put your mind at ease.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Rifabutin →

Rifampin

Insignificant Depletion

Brand names include Rifadin, Rimactane, Rifadin Injection

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Rifampin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses for energy production and healthy cell function, can theoretically dip a little when antibiotics like rifampin alter the natural bacteria living in your gut, since those bacteria do produce small amounts of riboflavin. That said, your gut flora contributes very little compared to what you get from food, so this interaction is rated as insignificant for most people. There is no need to worry about supplementing during rifampin therapy, but if you have questions about your diet or vitamin levels, your pharmacist or doctor is a great resource.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Rifampin →

Rifamycin

Insignificant Depletion

Brand names include Aemcolo

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Rifamycin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses to convert food into energy and keep skin and eyes healthy, can technically dip when you take antibiotics like rifamycin because these drugs may disrupt the gut bacteria that produce small amounts of it. That said, those bacteria contribute very little compared to what you get from food, so this is rated insignificant, meaning most people taking rifamycin have nothing to worry about here. No riboflavin supplement is generally needed, but if you have questions about your diet while on this antibiotic, your pharmacist is a good place to start.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Rifamycin →

Rifapentine

Insignificant Depletion

Brand names include Priftin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Rifapentine? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses for energy production and keeping skin, nerves, and red blood cells healthy. Rifapentine, like other antibiotics, can alter the natural bacteria living in your gut, and those bacteria do make a small amount of riboflavin. That said, your gut bacteria contribute very little to your overall riboflavin supply since most of it comes from the food you eat, so this interaction is considered insignificant. Most people taking rifapentine do not need a riboflavin supplement, but feel free to mention it to your pharmacist or doctor if you have concerns.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Rifapentine →

Rifaximin

Insignificant Depletion

Brand names include Xifaxan

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Rifaximin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses to convert food into energy and support healthy skin and nerves, is obtained mainly from the food you eat rather than from gut bacteria. Rifaximin works inside the intestines and can shift the balance of bacteria there, which in theory could reduce the small amount of riboflavin those bacteria produce. In practice, that bacterial contribution is so minor that rifaximin is not expected to meaningfully affect your riboflavin levels. This is rated an insignificant depletion, so most people do not need a supplement, but feel free to mention it to your pharmacist if you have any concerns.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Rifaximin →

Secnidazole

Insignificant Depletion

Brand names include Solosec

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Secnidazole? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body counts on for turning food into energy and keeping skin and nerves healthy. Secnidazole is an antibiotic, and antibiotics can disturb the friendly bacteria in your gut that normally produce small amounts of riboflavin. That said, your gut bacteria contribute very little compared to what you get from food, so this interaction is considered insignificant for most people. No riboflavin supplement is needed for a short antibiotic course like secnidazole, but feel free to mention it to your pharmacist if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Secnidazole →

Sparfloxacin

Insignificant Depletion

Brand names include Zagam

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Sparfloxacin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to convert food into energy and keep your skin and nerves healthy. Sparfloxacin, like other antibiotics, can disrupt the friendly bacteria living in your gut, and those bacteria do make a small amount of riboflavin. That said, because most of your riboflavin comes from food rather than gut bacteria, this effect is considered insignificant and a supplement is not something most people need during a short course of this antibiotic.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Sparfloxacin →

Spectinomycin

Insignificant Depletion

Brand names include Trobicin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Spectinomycin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to convert food into energy and keep skin and nerves healthy, may theoretically dip a little when you take an antibiotic like spectinomycin. The thinking is that antibiotics can disrupt the friendly bacteria living in your gut, and those bacteria do make small amounts of riboflavin. That said, your gut bacteria contribute very little compared to what you get from food, so this is considered insignificant in practice. For a short course of spectinomycin, there is really no need to worry about your riboflavin levels, but feel free to mention it to your pharmacist if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Spectinomycin →

Streptomycin

Insignificant Depletion
Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Streptomycin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to convert food into energy and keep skin, eyes, and nerves working well. Streptomycin, like other antibiotics, can disrupt the friendly bacteria living in your gut that produce small amounts of riboflavin, which could theoretically nudge levels down a little. In practice, because most of your riboflavin comes from food rather than gut bacteria, this effect is considered insignificant. Most people taking streptomycin do not need a riboflavin supplement, but if you have any concerns, your pharmacist or doctor is a good person to ask.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Streptomycin →

Sulbactam, Durlobactam

Insignificant Depletion

Brand names include Xacduro

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Sulbactam, Durlobactam? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses for energy production and keeping skin and tissues healthy, can sometimes dip slightly when antibiotics like sulbactam/durlobactam are on board. The thinking is that antibiotics disrupt the natural bacteria living in your gut, and those bacteria normally make small amounts of riboflavin. That said, your gut bacteria contribute very little to your overall riboflavin supply since most of it comes straight from the foods you eat. This interaction is rated insignificant, so for most patients no extra riboflavin is needed during this therapy.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Sulbactam, Durlobactam →

Sulfadiazine

Insignificant Depletion
Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Sulfadiazine? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to turn food into energy and keep skin and tissues healthy, is mostly something we get from what we eat rather than from bacteria living in the gut. Sulfadiazine, like other antibiotics, can disrupt those gut bacteria and slightly reduce the small amount of riboflavin they produce, but that contribution to your overall supply is pretty minimal. The evidence rates this as insignificant, meaning the vast majority of people taking sulfadiazine have no reason to worry about riboflavin levels or reach for a supplement. If you have questions about your diet or nutritional needs while on this antibiotic, your pharmacist or doctor is a great resource.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Sulfadiazine →

Brand names include Triple Sulfoid, Terfonyl

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Sulfadiazine, Sulfamerazine, Sulfamethazine? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body turn food into energy and keeps your skin and cells healthy. These sulfonamide antibiotics may slightly reduce the amount of riboflavin that gut bacteria produce, but here is the reassuring part: your body gets nearly all its riboflavin from the food you eat, not from bacteria, so that small reduction rarely matters. The evidence rates this as insignificant, meaning most people taking these antibiotics have no reason to add a riboflavin supplement. If you have concerns, your pharmacist or doctor is a good first stop.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Sulfadiazine, Sulfamerazine, Sulfamethazine →

Sulfadiazine, Trimethoprim

Insignificant Depletion

Brand names include Coptin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Sulfadiazine, Trimethoprim? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin and nervous system healthy. This antibiotic combination can reduce the amount of riboflavin that gut bacteria normally produce, but here is the reassuring part: your body gets the vast majority of its riboflavin from food anyway, so that bacterial contribution barely moves the needle. For most people taking sulfadiazine and trimethoprim, this is not a practical concern, and a riboflavin supplement is not needed. If you have questions about your diet or any symptoms, your pharmacist is a great first stop.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Sulfadiazine, Trimethoprim →

Sulfamerazine, Sulfamethazine

Insignificant Depletion

Brand names include Neotrizine

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Sulfamerazine, Sulfamethazine? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body turn food into energy and keeps your skin and nervous system healthy. Sulfonamide antibiotics like sulfamerazine and sulfamethazine may slightly reduce the amount of riboflavin that gut bacteria produce, but here is the reassuring part: your body gets nearly all its riboflavin from food anyway, so that small bacterial contribution barely matters. The evidence rates this as insignificant, meaning most people taking these medications have nothing to worry about and do not need a supplement.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Sulfamerazine, Sulfamethazine →

Sulfamethazole

Insignificant Depletion

Brand names include Proklar

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Sulfamethazole? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body needs to convert food into energy and keep your skin and cells healthy. Sulfamethazole, like other antibiotics, can affect the friendly bacteria living in your gut, and those bacteria do make a small amount of riboflavin. The thing is, that bacterial contribution is pretty minor since almost all of your riboflavin comes from the food you eat, so this interaction is rated insignificant. For most people taking this antibiotic, no extra riboflavin is needed, but feel free to mention it to your pharmacist if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Sulfamethazole →

Sulfamethizole

Insignificant Depletion

Brand names include Thiosulfil Forte

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Sulfamethizole? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses to turn food into energy and keep skin and eyes healthy, is mainly absorbed from what you eat rather than produced by gut bacteria. Sulfamethizole, like other antibiotics, can disrupt the bacteria living in your intestines, which do make a small amount of riboflavin on their own, but that bacterial contribution is considered minor. Because the effect is rated as insignificant, most people taking this antibiotic have nothing to worry about and do not need a riboflavin supplement. If you have questions about your diet or any vitamins, your pharmacist is a great first stop.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Sulfamethizole →

Sulfamethoxazole

Insignificant Depletion

Brand names include Gantanol

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Sulfamethoxazole? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to convert food into energy and keep skin and nerves healthy, may theoretically dip a little when you take sulfamethoxazole, because this antibiotic can disrupt the friendly bacteria in your gut that produce small amounts of it. That said, since your diet, not gut bacteria, is what really keeps riboflavin levels up, this effect is considered insignificant for most people. There is no need to reach for a riboflavin supplement during a course of sulfamethoxazole, but if you have concerns about your nutrition, your pharmacist or doctor is always a good person to check in with.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Sulfamethoxazole →

Sulfamethoxazole, Trimethoprim

Insignificant Depletion

Brand names include Bactrim, Bactrim DS, Cotrim DS

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Sulfamethoxazole, Trimethoprim? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, sometimes called vitamin B2, helps your body turn food into energy and keeps your skin and nervous system healthy. Trimethoprim-sulfamethoxazole is an antibiotic, and antibiotics can disrupt the helpful bacteria living in your gut that normally produce small amounts of riboflavin. That said, your gut bacteria contribute very little to your overall riboflavin supply since most of it comes straight from the foods you eat, so this interaction is considered insignificant for the vast majority of people. No extra riboflavin is needed during a typical course of this antibiotic, but feel free to ask your pharmacist if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Sulfamethoxazole, Trimethoprim →

Sulfapyridine

Insignificant Depletion
Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Sulfapyridine? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses for energy production and keeping skin, eyes, and nerves healthy. Sulfapyridine is an antibiotic, and like other antibiotics it can reduce the bacteria living in your gut that normally produce small amounts of riboflavin. That said, your gut bacteria aren't a major source of this vitamin anyway since most of it comes from food, so this effect is considered insignificant for most people. No riboflavin supplement is typically needed, but feel free to bring it up with your pharmacist if you have questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Sulfapyridine →

Sulfisoxazole

Insignificant Depletion

Brand names include Gantrisin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Sulfisoxazole? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to convert food into energy and keep skin and nerves healthy, is mostly absorbed from what you eat rather than from bacteria living in your gut. Sulfisoxazole, like other antibiotics, can disrupt those gut bacteria and reduce the small amount of riboflavin they produce, but since that bacterial contribution is minor to begin with, the overall effect on your riboflavin levels is considered insignificant. For most people taking this antibiotic, no extra riboflavin is needed, but if you have questions about your diet or any symptoms you are noticing, it is always fine to check in with your pharmacist.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Sulfisoxazole →

Tedizolid Phosphate

Insignificant Depletion

Brand names include Sivextro

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Tedizolid Phosphate? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses to convert food into energy and keep skin and nerves healthy, can theoretically dip a little when you take antibiotics like tedizolid phosphate. The reason is that antibiotics can disrupt the friendly bacteria living in your gut, and those bacteria do produce small amounts of riboflavin. That said, your gut bacteria contribute very little to your overall riboflavin supply since you get the vast majority from food, so this interaction is considered insignificant for most people. No riboflavin supplement is typically needed during a course of tedizolid phosphate, but if you have questions your pharmacist is a great first stop.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Tedizolid Phosphate →

Telavancin

Insignificant Depletion

Brand names include Vibativ

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Telavancin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body needs for energy production and healthy cells, comes mostly from the food you eat rather than from bacteria living in your gut. Telavancin, like other antibiotics, can disrupt those gut bacteria, which do produce a small amount of riboflavin, but that contribution is minor enough that it rarely matters in practice. For most people taking telavancin, this is considered an insignificant concern and a supplement is not needed. That said, if you have questions about your nutrition during antibiotic therapy, your pharmacist or doctor is always a good resource.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Telavancin →

Telithromycin

Insignificant Depletion

Brand names include Ketek

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Telithromycin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin, eyes, and nerves working properly. Telithromycin is an antibiotic, and like other antibiotics it can disrupt the friendly bacteria living in your gut that produce small amounts of riboflavin. That said, your body gets the vast majority of its riboflavin from the food you eat, not from gut bacteria, so this effect is considered insignificant for most people. No riboflavin supplement is needed during a course of this antibiotic, though your pharmacist is always happy to answer questions.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Telithromycin →

Temafloxacin

Insignificant Depletion

Brand names include Omniflox

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Temafloxacin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses for energy production and cell function, is mainly absorbed from the food you eat rather than made by gut bacteria. Temafloxacin, like other antibiotics, can disrupt the natural bacteria in your intestines, which do produce a small amount of riboflavin, but research suggests that contribution is too minor to meaningfully affect your overall levels. For most people taking this antibiotic, this interaction is considered insignificant and a supplement is not needed. That said, if you have questions about your diet or any vitamins, your pharmacist is always a good person to check with.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Temafloxacin →

Tetracycline

Insignificant Depletion

Brand names include Sumycin, Sumycin 250, Tetrex BID

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Tetracycline? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body turn food into energy and keeps your skin, eyes, and nerves working well. Tetracycline and other antibiotics can disrupt the friendly bacteria living in your gut, and those bacteria do produce small amounts of riboflavin on their own. That said, most of what your body actually needs comes from the food you eat, so this particular effect is considered insignificant for most people. No supplement is needed during a typical course of tetracycline, but if you have questions about your diet or vitamin intake, your pharmacist or doctor is a great place to start.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Tetracycline →

Ticarcillin

Insignificant Depletion

Brand names include Ticar

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Ticarcillin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body turn food into energy and keeps skin, eyes, and nerves working well. Ticarcillin is an antibiotic, and antibiotics can disrupt the friendly bacteria living in your gut that normally produce small amounts of riboflavin. That said, your gut bacteria contribute very little to your overall riboflavin supply compared to what you get from food, so this interaction is considered insignificant for most people. No riboflavin supplement is needed during a course of ticarcillin, but if you have questions about your nutrition while on antibiotics, your pharmacist is always a good first stop.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Ticarcillin →

Ticarcillin , Clavulanate

Insignificant Depletion

Brand names include Timentin

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Ticarcillin , Clavulanate? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body needs to convert food into energy and keep your skin and tissues healthy. Ticarcillin with clavulanate, like other antibiotics, can shift the natural bacteria living in your gut, and those bacteria do produce small amounts of riboflavin. That said, your gut flora's contribution to your overall riboflavin supply is quite minor compared to what you get from food, so this is rated as an insignificant depletion. Most people taking this antibiotic do not need a riboflavin supplement, but if you have questions about your diet or nutritional needs, your pharmacist or doctor is a great place to start.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Ticarcillin , Clavulanate →

Tigecycline

Insignificant Depletion

Brand names include Tygacil

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Tigecycline? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body uses to convert food into energy and support healthy cells, is mainly absorbed from what you eat rather than produced by gut bacteria. Tigecycline, like other antibiotics, can disrupt the natural bacteria living in your intestines, which do make small amounts of riboflavin, but that bacterial contribution is considered minor. Because your diet supplies most of what you need, this is rated as an insignificant concern for most people. No supplement is typically necessary, but if you have questions about your nutrition during treatment, your pharmacist or doctor is a great resource.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Tigecycline →

Tobramycin

Insignificant Depletion

Brand names include Nebcin, Tobi Podhaler, Bethkis

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Tobramycin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin, eyes, and nerves working properly. Tobramycin, like other antibiotics, can disrupt the natural bacteria living in your gut, and those bacteria do produce a small amount of riboflavin. The key word there is small: your body gets the vast majority of its riboflavin from the food you eat, so this effect is considered insignificant for most people. No extra supplementation is needed, but if you have questions about your nutrition while on this antibiotic, your pharmacist or doctor is a great resource.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Tobramycin →

Trimethoprim

Insignificant Depletion

Brand names include Proloprim, Trimpex

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Trimethoprim? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to convert food into energy and keep skin and nerves healthy, can theoretically dip a little when you take trimethoprim. The thinking is that antibiotics like trimethoprim can disrupt the friendly bacteria in your gut that produce small amounts of riboflavin. In practice, though, your diet supplies the vast majority of what your body needs, so this barely registers as a concern. Most people taking trimethoprim do not need a riboflavin supplement, but if you have questions about your specific situation, your pharmacist is a good person to ask.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Trimethoprim →

Trimipramine

Insignificant Depletion

Brand names include Surmontil, Trimip, Rhotrimine

TCAs might reduce active riboflavin levels; however, this is not likely to be clinically significant.
TCAs have structural similarities to riboflavin and can interfere with its conversion to the active form flavin adenine dinucleotide (FAD). In animal models, very high doses of amitriptyline and imipramine (50 mg/kg daily) decrease FAD levels in the liver, heart, and brain. Lower doses (10 mg/kg daily) only affect levels in the heart. Since these doses are higher than those used therapeutically in humans, it is unlikely that the effect is clinically significant or that supplements are necessary.
Taking Trimipramine? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin is a B vitamin your body uses to convert food into energy and keep cells working properly. Trimipramine belongs to a drug class whose chemical structure is similar enough to riboflavin that it may interfere with the process that turns riboflavin into its active, working form in the body. That said, the evidence here is reassuring: the effect has mainly been seen in animals given doses far higher than any human would take, so this is rated insignificant for most people. No action is needed, but if you have questions about your nutritional health on this medication, your pharmacist or doctor is a good place to start.

References (2)
  1. Pinto J, Huang YP, Rivlin RS. Inhibition of riboflavin metabolism in rat tissues by chlorpromazine, imipramine and amitriptyline. J Clin Invest 1981;67:1500-6. PubMed
  2. Pinto J, Huang YP, Pelliccione N, Rivlin RS. Cardiac sensitivity to the inhibitory effects of chlorpromazine, imipramine, and amitriptyline upon formation of flavins. Biochem Pharmacol 1982;31:3495-9.. PubMed

Full nutrient report for Trimipramine →

Troleandomycin

Insignificant Depletion

Brand names include Tao

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Troleandomycin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, a B vitamin your body needs for energy production and healthy cell function, is mostly absorbed from the foods you eat rather than made by gut bacteria. Troleandomycin is an antibiotic, and like other antibiotics it can disrupt the normal bacteria living in your gut, which do produce small amounts of riboflavin. That said, because dietary sources do the heavy lifting here, this disruption is not considered clinically meaningful for most people. The rating on this one is insignificant, so riboflavin supplementation is not something most patients need to think about while taking this medication.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Troleandomycin →

Trovafloxacin

Insignificant Depletion

Brand names include Trovan, Trovan Injection

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Trovafloxacin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body turn food into energy and keeps your skin, nerves, and eyes healthy. Trovafloxacin, like other antibiotics, can disrupt the natural bacteria living in your gut, and those bacteria do produce a small amount of riboflavin. That said, the vast majority of riboflavin your body uses comes straight from the food you eat, so any dip from this antibiotic is considered insignificant. Most people taking trovafloxacin have nothing to worry about here, but if you have questions about your diet or vitamin intake, your pharmacist is happy to help.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Trovafloxacin →

Vancomycin

Insignificant Depletion

Brand names include Vancocin, Vancoled

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Vancomycin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to turn food into energy and keep skin and nerves healthy, can technically dip a little when you take an antibiotic like vancomycin. The reason is that antibiotics can disrupt the friendly bacteria living in your gut, and those bacteria do produce some riboflavin. That said, your gut bacteria are actually a pretty minor source compared to what you get from food, so this is rated as insignificant for most patients. No supplement is needed for the average person on vancomycin, but if you have questions about your diet or nutrition during treatment, your pharmacist or doctor is a great place to start.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Vancomycin →

Vancomycin Hydrochloride

Insignificant Depletion

Brand names include Firvanq

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Vancomycin Hydrochloride? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to convert food into energy and keep skin and nerves healthy, is obtained mainly from what you eat rather than from bacteria living in your gut. Vancomycin, like other antibiotics, can reduce those gut bacteria and may slightly lower the small amount of riboflavin they produce, but researchers consider this shift too minor to matter for most people. In plain terms, this is listed as insignificant, so the vast majority of patients on vancomycin do not need a riboflavin supplement. That said, if you have questions about your diet or nutritional needs during treatment, your pharmacist or doctor is a great person to ask.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Vancomycin Hydrochloride →

Vonoprazan, Amoxicillin

Insignificant Depletion

Brand names include Voquezna Dual

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Vonoprazan, Amoxicillin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and supports healthy skin and nerves. Amoxicillin, the antibiotic in this combination, can alter the natural bacteria living in your gut, and those bacteria do produce small amounts of riboflavin. That said, because most of your riboflavin comes from food rather than gut bacteria, this effect is considered insignificant, and a supplement is not needed for most people taking this regimen.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Vonoprazan, Amoxicillin →

Vonoprazan, Amoxicillin, Clarithromycin

Insignificant Depletion

Brand names include Voquezna Triple

Antibiotic drugs might reduce riboflavin levels; however, this is not likely to be clinically significant.
Interference with the normal gastrointestinal flora by antibiotics may reduce bacterial synthesis of riboflavin. However, this synthesis doesn't seem to significantly contribute to the body's supply of riboflavin, which is primarily obtained from dietary sources. Riboflavin supplements aren't necessary during antibiotic therapy.
Taking Vonoprazan, Amoxicillin, Clarithromycin? A supplement is not needed for most patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses for energy production and keeping skin, nerves, and red blood cells healthy. When antibiotics like amoxicillin and clarithromycin are taken, they can disrupt the natural bacteria living in your gut, which normally produce small amounts of riboflavin on their own. That said, your gut bacteria are not a major source of this vitamin anyway since you get most of it from food, so this interaction is rated as insignificant and supplements are not considered necessary for most people taking this combination. No action is needed for the average patient, but if you have questions or eat a very limited diet, it is always fine to check in with your pharmacist.

References (3)
  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. PubMed
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. pg.391-9.

Full nutrient report for Vonoprazan, Amoxicillin, Clarithromycin →

Brand names include Triple Barbital

Phenobarbital might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Some evidence in animals suggests that phenobarbital induces metabolism of riboflavin in the liver. Levels of the active form of riboflavin, flavin adenine dinucleotide (FAD), are increased in the liver and levels of a hydroxylated metabolite are increased in the urine. Also, some animal research suggests that phenobarbital does not significantly affect the content of flavin in the liver.
Taking Aprobarbital, Butabarbital, Phenobarbital? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to convert food into energy and keep your cells working properly. Animal studies suggest phenobarbital may prompt the liver to process riboflavin faster than usual, potentially affecting active levels in the body, though other animal research has found no meaningful change. The honest bottom line here is that the evidence is too limited to know whether this matters for people at all. If you have been on one of these barbiturates long-term and have questions, it is worth bringing up with your pharmacist or doctor just to be sure.

References (3)
  1. Ohkawa H, Ohishi N, Yagi K. Hydroxylation of the 7- and 8-methyl groups of riboflavin by the microsomal electron transfer system of rat liver. J Biol Chem 1983;258:5629-33.. DOI
  2. Hamajima S, Ono S, Hirano H, Obara K. Induction of the FAD synthetase system in rat liver by phenobarbital administration. Int J Vit Nutr Res 1979;49:59-63..
  3. Shargel L, Mazel P. Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat. Biochem Pharmacol. 1973;22(19):2365-73. PubMed

Full nutrient report for Aprobarbital, Butabarbital, Phenobarbital →

Brand names include Phenaphen

Phenobarbital might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Some evidence in animals suggests that phenobarbital induces metabolism of riboflavin in the liver. Levels of the active form of riboflavin, flavin adenine dinucleotide (FAD), are increased in the liver and levels of a hydroxylated metabolite are increased in the urine. Also, some animal research suggests that phenobarbital does not significantly affect the content of flavin in the liver.
Taking Aspirin, Codeine Phosphate, Phenobarbital? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin, nerves, and eyes working well. Some animal studies suggest phenobarbital may cause the liver to process riboflavin faster than usual, which could affect how much of the active form stays available in the body. That said, the evidence is only from animal research and the picture is mixed, so this is not a confirmed concern in people. Most patients taking this medication do not need to act on this, but if you have been on phenobarbital long-term and want to talk it through, your pharmacist or doctor is a great place to start.

References (3)
  1. Ohkawa H, Ohishi N, Yagi K. Hydroxylation of the 7- and 8-methyl groups of riboflavin by the microsomal electron transfer system of rat liver. J Biol Chem 1983;258:5629-33.. DOI
  2. Hamajima S, Ono S, Hirano H, Obara K. Induction of the FAD synthetase system in rat liver by phenobarbital administration. Int J Vit Nutr Res 1979;49:59-63..
  3. Shargel L, Mazel P. Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat. Biochem Pharmacol. 1973;22(19):2365-73. PubMed

Full nutrient report for Aspirin, Codeine Phosphate, Phenobarbital →

Atropine, Hyoscyamine, Phenobarbital

Insufficient Evidence

Brand names include Hypnaldyne

Phenobarbital might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Some evidence in animals suggests that phenobarbital induces metabolism of riboflavin in the liver. Levels of the active form of riboflavin, flavin adenine dinucleotide (FAD), are increased in the liver and levels of a hydroxylated metabolite are increased in the urine. Also, some animal research suggests that phenobarbital does not significantly affect the content of flavin in the liver.
Taking Atropine, Hyoscyamine, Phenobarbital? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body turn food into energy and keeps your skin, nerves, and eyes healthy. The phenobarbital component of this combination may cause the liver to process riboflavin faster than usual, potentially lowering active levels in the body. That said, the research on this is early, partly from animal studies, and the results are mixed, so its real-world significance in people is simply not known yet. If you have been on this medication long-term and have concerns, it is worth bringing up with your pharmacist or doctor.

References (3)
  1. Ohkawa H, Ohishi N, Yagi K. Hydroxylation of the 7- and 8-methyl groups of riboflavin by the microsomal electron transfer system of rat liver. J Biol Chem 1983;258:5629-33.. DOI
  2. Hamajima S, Ono S, Hirano H, Obara K. Induction of the FAD synthetase system in rat liver by phenobarbital administration. Int J Vit Nutr Res 1979;49:59-63..
  3. Shargel L, Mazel P. Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat. Biochem Pharmacol. 1973;22(19):2365-73. PubMed

Full nutrient report for Atropine, Hyoscyamine, Phenobarbital →

Brand names include Barbidonna No. 2, Belladonna Phenobarbital

Phenobarbital might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Some evidence in animals suggests that phenobarbital induces metabolism of riboflavin in the liver. Levels of the active form of riboflavin, flavin adenine dinucleotide (FAD), are increased in the liver and levels of a hydroxylated metabolite are increased in the urine. Also, some animal research suggests that phenobarbital does not significantly affect the content of flavin in the liver.
Taking Atropine, Hyoscyamine, Phenobarbital, Scopolamine? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin, nerves, and eyes healthy. The phenobarbital component in this combination may prompt the liver to process riboflavin faster than usual, which animal studies suggest could shift how the body handles it, though the research is mixed and some studies show no real change. Right now there simply is not enough human evidence to know whether this matters clinically, so most people taking this medication do not need to act on it. That said, if you take this medication long-term, it is worth mentioning to your pharmacist or doctor at your next visit.

References (3)
  1. Ohkawa H, Ohishi N, Yagi K. Hydroxylation of the 7- and 8-methyl groups of riboflavin by the microsomal electron transfer system of rat liver. J Biol Chem 1983;258:5629-33.. DOI
  2. Hamajima S, Ono S, Hirano H, Obara K. Induction of the FAD synthetase system in rat liver by phenobarbital administration. Int J Vit Nutr Res 1979;49:59-63..
  3. Shargel L, Mazel P. Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat. Biochem Pharmacol. 1973;22(19):2365-73. PubMed

Full nutrient report for Atropine, Hyoscyamine, Phenobarbital, Scopolamine →

Brand names include Barbeloid, Donnatal #2, Donphen

Phenobarbital might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Some evidence in animals suggests that phenobarbital induces metabolism of riboflavin in the liver. Levels of the active form of riboflavin, flavin adenine dinucleotide (FAD), are increased in the liver and levels of a hydroxylated metabolite are increased in the urine. Also, some animal research suggests that phenobarbital does not significantly affect the content of flavin in the liver.
Taking Atropine, Hyoscyamine, Scopolamine, Phenobarbital? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to convert food into energy and keep cells working properly, may be affected by the phenobarbital component in this combination medication. Animal studies suggest phenobarbital might prompt the liver to break riboflavin down faster than usual, potentially shifting how much of the active form is available. That said, the research is inconsistent and comes mostly from animal studies, so the real-world significance for people is simply not known. Most people taking this medication do not need to act on this, but if you have questions about your riboflavin status, it is always worth a conversation with your pharmacist or doctor.

References (3)
  1. Ohkawa H, Ohishi N, Yagi K. Hydroxylation of the 7- and 8-methyl groups of riboflavin by the microsomal electron transfer system of rat liver. J Biol Chem 1983;258:5629-33.. DOI
  2. Hamajima S, Ono S, Hirano H, Obara K. Induction of the FAD synthetase system in rat liver by phenobarbital administration. Int J Vit Nutr Res 1979;49:59-63..
  3. Shargel L, Mazel P. Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat. Biochem Pharmacol. 1973;22(19):2365-73. PubMed

Full nutrient report for Atropine, Hyoscyamine, Scopolamine, Phenobarbital →

Belladona Extract, Phenobarbital

Insufficient Evidence

Brand names include Chardonna-2

Phenobarbital might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Some evidence in animals suggests that phenobarbital induces metabolism of riboflavin in the liver. Levels of the active form of riboflavin, flavin adenine dinucleotide (FAD), are increased in the liver and levels of a hydroxylated metabolite are increased in the urine. Also, some animal research suggests that phenobarbital does not significantly affect the content of flavin in the liver.
Taking Belladona Extract, Phenobarbital? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin is a B vitamin your body uses to convert food into energy and keep cells working properly. Some animal studies suggest phenobarbital may cause the liver to process riboflavin faster than usual, potentially affecting levels of its active form, but the research is mixed and no one has clearly shown this is a real problem in people. Given that the evidence is truly insufficient right now, there is no reason to worry, though long-term users of phenobarbital can always mention it to their pharmacist just to keep an eye on things.

References (3)
  1. Ohkawa H, Ohishi N, Yagi K. Hydroxylation of the 7- and 8-methyl groups of riboflavin by the microsomal electron transfer system of rat liver. J Biol Chem 1983;258:5629-33.. DOI
  2. Hamajima S, Ono S, Hirano H, Obara K. Induction of the FAD synthetase system in rat liver by phenobarbital administration. Int J Vit Nutr Res 1979;49:59-63..
  3. Shargel L, Mazel P. Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat. Biochem Pharmacol. 1973;22(19):2365-73. PubMed

Full nutrient report for Belladona Extract, Phenobarbital →

Brand names include Bellaphen-S, Spastrin, Phenarbal S

Phenobarbital might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Some evidence in animals suggests that phenobarbital induces metabolism of riboflavin in the liver. Levels of the active form of riboflavin, flavin adenine dinucleotide (FAD), are increased in the liver and levels of a hydroxylated metabolite are increased in the urine. Also, some animal research suggests that phenobarbital does not significantly affect the content of flavin in the liver.
Taking Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to convert food into energy and keep cells functioning properly. The phenobarbital component of this combination may prompt the liver to process riboflavin more quickly than usual, potentially affecting levels of its active working form. That said, the research here is largely from animal studies and the results are mixed, so how much this actually matters in people is genuinely unclear. If you have been on this medication long term, it is worth mentioning to your pharmacist or doctor, but there is no strong reason for concern right now.

References (3)
  1. Ohkawa H, Ohishi N, Yagi K. Hydroxylation of the 7- and 8-methyl groups of riboflavin by the microsomal electron transfer system of rat liver. J Biol Chem 1983;258:5629-33.. DOI
  2. Hamajima S, Ono S, Hirano H, Obara K. Induction of the FAD synthetase system in rat liver by phenobarbital administration. Int J Vit Nutr Res 1979;49:59-63..
  3. Shargel L, Mazel P. Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat. Biochem Pharmacol. 1973;22(19):2365-73. PubMed

Full nutrient report for Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital →

Belladonna Alkaloids, Phenobarbital

Insufficient Evidence

Brand names include Barbidonna, Donnatal

Phenobarbital might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Some evidence in animals suggests that phenobarbital induces metabolism of riboflavin in the liver. Levels of the active form of riboflavin, flavin adenine dinucleotide (FAD), are increased in the liver and levels of a hydroxylated metabolite are increased in the urine. Also, some animal research suggests that phenobarbital does not significantly affect the content of flavin in the liver.
Taking Belladonna Alkaloids, Phenobarbital? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to convert food into energy and keep cells working properly. Animal research suggests phenobarbital may speed up how the liver processes riboflavin, potentially changing the levels of its active form in the body. That said, the evidence here is limited to animal studies and the results are mixed, so we simply do not know whether this matters clinically for people. If you have been taking phenobarbital long-term and have questions, it is worth bringing up with your pharmacist or doctor.

References (3)
  1. Ohkawa H, Ohishi N, Yagi K. Hydroxylation of the 7- and 8-methyl groups of riboflavin by the microsomal electron transfer system of rat liver. J Biol Chem 1983;258:5629-33.. DOI
  2. Hamajima S, Ono S, Hirano H, Obara K. Induction of the FAD synthetase system in rat liver by phenobarbital administration. Int J Vit Nutr Res 1979;49:59-63..
  3. Shargel L, Mazel P. Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat. Biochem Pharmacol. 1973;22(19):2365-73. PubMed

Full nutrient report for Belladonna Alkaloids, Phenobarbital →

Belladonna Extract, Phenobarbital

Insufficient Evidence

Brand names include Belap

Phenobarbital might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Some evidence in animals suggests that phenobarbital induces metabolism of riboflavin in the liver. Levels of the active form of riboflavin, flavin adenine dinucleotide (FAD), are increased in the liver and levels of a hydroxylated metabolite are increased in the urine. Also, some animal research suggests that phenobarbital does not significantly affect the content of flavin in the liver.
Taking Belladonna Extract, Phenobarbital? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to convert food into energy and keep cells working properly, may be processed faster when phenobarbital is on board. Animal studies suggest the drug prompts the liver to break down riboflavin more quickly than usual, though results across studies have been mixed. Because the evidence in humans is limited and the rating is 'insufficient,' this is more of an open question than a confirmed concern. If you have been on this medication long term, it is worth mentioning to your pharmacist or doctor at your next visit.

References (3)
  1. Ohkawa H, Ohishi N, Yagi K. Hydroxylation of the 7- and 8-methyl groups of riboflavin by the microsomal electron transfer system of rat liver. J Biol Chem 1983;258:5629-33.. DOI
  2. Hamajima S, Ono S, Hirano H, Obara K. Induction of the FAD synthetase system in rat liver by phenobarbital administration. Int J Vit Nutr Res 1979;49:59-63..
  3. Shargel L, Mazel P. Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat. Biochem Pharmacol. 1973;22(19):2365-73. PubMed

Full nutrient report for Belladonna Extract, Phenobarbital →

Brand names include Bellergal-S

Phenobarbital might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Some evidence in animals suggests that phenobarbital induces metabolism of riboflavin in the liver. Levels of the active form of riboflavin, flavin adenine dinucleotide (FAD), are increased in the liver and levels of a hydroxylated metabolite are increased in the urine. Also, some animal research suggests that phenobarbital does not significantly affect the content of flavin in the liver.
Taking Belladonna, Ergotamine, Phenobarbital? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin, eyes, and nerves working properly. The phenobarbital component of this combination may prompt the liver to process riboflavin more quickly than usual, which in theory could nudge active riboflavin levels a bit lower. That said, the research here comes mostly from animal studies and the findings are mixed, so for most people taking this medication the real-world impact is simply not known. If you have been on this medication long-term, mentioning it to your pharmacist or doctor is a reasonable step, but there is no clear reason for alarm right now.

References (3)
  1. Ohkawa H, Ohishi N, Yagi K. Hydroxylation of the 7- and 8-methyl groups of riboflavin by the microsomal electron transfer system of rat liver. J Biol Chem 1983;258:5629-33.. DOI
  2. Hamajima S, Ono S, Hirano H, Obara K. Induction of the FAD synthetase system in rat liver by phenobarbital administration. Int J Vit Nutr Res 1979;49:59-63..
  3. Shargel L, Mazel P. Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat. Biochem Pharmacol. 1973;22(19):2365-73. PubMed

Full nutrient report for Belladonna, Ergotamine, Phenobarbital →

Belladonna, Phenobarbital

Insufficient Evidence

Brand names include Bellophen, Susano

Phenobarbital might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Some evidence in animals suggests that phenobarbital induces metabolism of riboflavin in the liver. Levels of the active form of riboflavin, flavin adenine dinucleotide (FAD), are increased in the liver and levels of a hydroxylated metabolite are increased in the urine. Also, some animal research suggests that phenobarbital does not significantly affect the content of flavin in the liver.
Taking Belladonna, Phenobarbital? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin is a B vitamin your body uses to convert food into energy and keep cells working properly. There is some animal research suggesting phenobarbital may speed up how the liver processes riboflavin, potentially affecting levels of its active form, but the studies are mixed and none of this has been clearly shown to matter in people. Because the evidence is genuinely uncertain, most patients taking this medication do not need to act on this right now. If you are curious or have been on phenobarbital long-term, it is worth mentioning to your pharmacist or doctor.

References (3)
  1. Ohkawa H, Ohishi N, Yagi K. Hydroxylation of the 7- and 8-methyl groups of riboflavin by the microsomal electron transfer system of rat liver. J Biol Chem 1983;258:5629-33.. DOI
  2. Hamajima S, Ono S, Hirano H, Obara K. Induction of the FAD synthetase system in rat liver by phenobarbital administration. Int J Vit Nutr Res 1979;49:59-63..
  3. Shargel L, Mazel P. Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat. Biochem Pharmacol. 1973;22(19):2365-73. PubMed

Full nutrient report for Belladonna, Phenobarbital →

Bellafoline, Phenobarbital

Insufficient Evidence

Brand names include Belladenal, Belladenal-S

Phenobarbital might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Some evidence in animals suggests that phenobarbital induces metabolism of riboflavin in the liver. Levels of the active form of riboflavin, flavin adenine dinucleotide (FAD), are increased in the liver and levels of a hydroxylated metabolite are increased in the urine. Also, some animal research suggests that phenobarbital does not significantly affect the content of flavin in the liver.
Taking Bellafoline, Phenobarbital? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin is a B vitamin your body uses to convert food into energy and keep cells working properly. Some animal research suggests phenobarbital may cause the liver to process riboflavin faster than usual, potentially affecting levels of its active form. That said, other animal studies did not find a meaningful effect, and there is not enough human evidence yet to know whether this matters in practice. For now, most people taking this medication do not need to act on this, but if you have been on it long-term, it is worth mentioning to your pharmacist or doctor.

References (3)
  1. Ohkawa H, Ohishi N, Yagi K. Hydroxylation of the 7- and 8-methyl groups of riboflavin by the microsomal electron transfer system of rat liver. J Biol Chem 1983;258:5629-33.. DOI
  2. Hamajima S, Ono S, Hirano H, Obara K. Induction of the FAD synthetase system in rat liver by phenobarbital administration. Int J Vit Nutr Res 1979;49:59-63..
  3. Shargel L, Mazel P. Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat. Biochem Pharmacol. 1973;22(19):2365-73. PubMed

Full nutrient report for Bellafoline, Phenobarbital →

Brand names include S.B.P.

Phenobarbital might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Some evidence in animals suggests that phenobarbital induces metabolism of riboflavin in the liver. Levels of the active form of riboflavin, flavin adenine dinucleotide (FAD), are increased in the liver and levels of a hydroxylated metabolite are increased in the urine. Also, some animal research suggests that phenobarbital does not significantly affect the content of flavin in the liver.
Taking Butabarbital, Phenobarbital, Secobarbital? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to convert food into energy and keep cells functioning well. Animal studies hint that barbiturates like phenobarbital may cause the liver to process riboflavin faster than usual, potentially shifting how the active form gets used, but this has not been clearly shown in people. The evidence here is genuinely too thin to know whether it matters at all in practice, so most people taking these medications do not need to act on this right now. That said, if you have questions or take one of these drugs long term, it is always fine to bring it up with your pharmacist or doctor.

References (3)
  1. Ohkawa H, Ohishi N, Yagi K. Hydroxylation of the 7- and 8-methyl groups of riboflavin by the microsomal electron transfer system of rat liver. J Biol Chem 1983;258:5629-33.. DOI
  2. Hamajima S, Ono S, Hirano H, Obara K. Induction of the FAD synthetase system in rat liver by phenobarbital administration. Int J Vit Nutr Res 1979;49:59-63..
  3. Shargel L, Mazel P. Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat. Biochem Pharmacol. 1973;22(19):2365-73. PubMed

Full nutrient report for Butabarbital, Phenobarbital, Secobarbital →

Brand names include Tribarb

Phenobarbital might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Some evidence in animals suggests that phenobarbital induces metabolism of riboflavin in the liver. Levels of the active form of riboflavin, flavin adenine dinucleotide (FAD), are increased in the liver and levels of a hydroxylated metabolite are increased in the urine. Also, some animal research suggests that phenobarbital does not significantly affect the content of flavin in the liver.
Taking Butalbital, Phenobarbital, Secobarbital? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin is a B vitamin your body uses to convert food into energy and keep cells working properly. Animal studies hint that phenobarbital may cause the liver to break down riboflavin faster than normal, potentially nudging active levels a bit lower, but this has not been clearly proven in people. Given the insufficient evidence rating, this is more of an open question than a known concern, so most people taking these barbiturates do not need to act on this right now. If you are a long-term user and curious, it is worth bringing up with your pharmacist or doctor.

References (3)
  1. Ohkawa H, Ohishi N, Yagi K. Hydroxylation of the 7- and 8-methyl groups of riboflavin by the microsomal electron transfer system of rat liver. J Biol Chem 1983;258:5629-33.. DOI
  2. Hamajima S, Ono S, Hirano H, Obara K. Induction of the FAD synthetase system in rat liver by phenobarbital administration. Int J Vit Nutr Res 1979;49:59-63..
  3. Shargel L, Mazel P. Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat. Biochem Pharmacol. 1973;22(19):2365-73. PubMed

Full nutrient report for Butalbital, Phenobarbital, Secobarbital →

Brand names include Nevrotose #3

Phenobarbital might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Some evidence in animals suggests that phenobarbital induces metabolism of riboflavin in the liver. Levels of the active form of riboflavin, flavin adenine dinucleotide (FAD), are increased in the liver and levels of a hydroxylated metabolite are increased in the urine. Also, some animal research suggests that phenobarbital does not significantly affect the content of flavin in the liver.
Taking Camphor, Hyoscyamine, Passif, Phenobarbital, Scopolamine, Valerian? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin is a B vitamin your body uses to convert food into energy and keep cells running properly. Phenobarbital, one of the ingredients in this combination, may prompt the liver to process riboflavin faster than usual, which could theoretically affect active riboflavin levels in the body. That said, the evidence here comes mostly from animal studies and the picture is mixed, so the real-world significance for people is simply not known yet. If you take this medication long term, it is worth mentioning to your pharmacist or doctor just to keep it on their radar.

References (3)
  1. Ohkawa H, Ohishi N, Yagi K. Hydroxylation of the 7- and 8-methyl groups of riboflavin by the microsomal electron transfer system of rat liver. J Biol Chem 1983;258:5629-33.. DOI
  2. Hamajima S, Ono S, Hirano H, Obara K. Induction of the FAD synthetase system in rat liver by phenobarbital administration. Int J Vit Nutr Res 1979;49:59-63..
  3. Shargel L, Mazel P. Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat. Biochem Pharmacol. 1973;22(19):2365-73. PubMed

Full nutrient report for Camphor, Hyoscyamine, Passif, Phenobarbital, Scopolamine, Valerian →

Chlorpromazine

Insufficient Evidence

Brand names include Thorazine, Thorazine Spansules

Chlorpromazine might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Chlorpromazine has structural similarities to riboflavin and can interfere with its conversion to the active form, flavin adenine dinucleotide (FAD). In rats, chlorpromazine decreases FAD levels in the liver, kidneys, heart and skeletal muscle, increases urinary riboflavin excretion, and produces changes in erythrocyte enzyme activity consistent with riboflavin deficiency. Chlorpromazine also inhibits renal tubular secretion and reabsorption of riboflavin. Although these effects occur in rats at similar doses to those used in humans, data in humans are lacking. There isn't enough evidence to recommend use of riboflavin supplements with chlorpromazine or other phenothiazines.
Taking Chlorpromazine? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body produce energy and keeps your skin, nerves, and red blood cells working properly. Chlorpromazine is chemically shaped in a way that may interfere with how the body converts riboflavin into its active, usable form, and it may also affect how the kidneys handle riboflavin. That said, this has really only been studied in animals, and there is not enough human data to know whether it matters at a practical level. Most people taking chlorpromazine do not need to act on this right now, but if you have questions or take this medication long-term, it is worth a quick conversation with your pharmacist or doctor.

References (5)
  1. Pinto J, Huang YP, Rivlin RS. Inhibition of riboflavin metabolism in rat tissues by chlorpromazine, imipramine and amitriptyline. J Clin Invest 1981;67:1500-6. PubMed
  2. Pinto J, Huang YP, Pelliccione N, Rivlin RS. Cardiac sensitivity to the inhibitory effects of chlorpromazine, imipramine, and amitriptyline upon formation of flavins. Biochem Pharmacol 1982;31:3495-9.. PubMed
  3. Pelliccione N, Pinto J, Huang YP, Rivlin RS. Accelerated development of riboflavin deficiency by treatment with chlorpromazine. Biochem Pharmacol 1983;32:2949-53.. PubMed
  4. Raiczyk GB, Dutta P, Pinto J. Chlorpromazine and quinacrine inhibit flavin adenine dinucleotide biosynthesis in skeletal muscle. Physiologist 1985;28:322.
  5. Yanagawa N, Shih RN, Jo OD, Said HM. Riboflavin transport by isolated perfused rabbit renal proximal tubules. Am J Physiol Cell Physiol 2000;279:C1782-6.. PubMed

Full nutrient report for Chlorpromazine →

Colchicine, Probenecid

Insufficient Evidence

Brand names include ColBenemid

Probenecid might reduce active riboflavin levels; however, the clinical significance of this is unclear.
In humans, probenecid reduces renal tubular secretion and total urinary excretion of both supplemental and dietary riboflavin. It may also reduce the active intestinal absorption mechanism for riboflavin. After single doses of probenecid, the effect on renal excretion predominates, and plasma riboflavin levels are increased. The effect of prolonged probenecid therapy on riboflavin balance, and therefore the clinical significance, is not known.
Taking Colchicine, Probenecid? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin, nerves, and red blood cells working properly. Probenecid appears to interfere with how the kidneys handle riboflavin, and possibly with how the gut absorbs it, though interestingly a single dose may actually raise riboflavin levels in the blood temporarily. The honest takeaway here is that researchers simply do not know yet whether long-term probenecid use meaningfully affects your riboflavin stores, so most people taking it do not need to worry about this right now. Still, if you have been on probenecid for a long time and have questions, a quick conversation with your pharmacist or doctor is always a reasonable idea.

References (3)
  1. Yanagawa N, Shih RN, Jo OD, Said HM. Riboflavin transport by isolated perfused rabbit renal proximal tubules. Am J Physiol Cell Physiol 2000;279:C1782-6.. PubMed
  2. Jusko WJ, Levy G. Effect of probenecid on riboflavin absorption and excretion in man. J Pharm Sci 1967;56:1145-9. PubMed
  3. Jusko WJ, Levy G, Yaffe SJ, Gorodischer R. Effect of probenecid on renal clearance of riboflavin in man.J Pharm Sci 1970;59:473-7. DOI

Full nutrient report for Colchicine, Probenecid →

Brand names include G.B.S.

Phenobarbital might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Some evidence in animals suggests that phenobarbital induces metabolism of riboflavin in the liver. Levels of the active form of riboflavin, flavin adenine dinucleotide (FAD), are increased in the liver and levels of a hydroxylated metabolite are increased in the urine. Also, some animal research suggests that phenobarbital does not significantly affect the content of flavin in the liver.
Taking Dehydrocholic Acid, Homatropine Methylbromide, Phenobarbital? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin, eyes, and nerves working properly. The phenobarbital component of this combination product may prompt the liver to process riboflavin more quickly than usual, which animal studies suggest could shift how the body handles its active form. That said, the evidence here is quite limited and comes mostly from animal research, so the real-world impact in people is simply not known yet. Most patients taking this medication do not need to take action, but if you have been on it long-term and are curious, it is worth a quick conversation with your pharmacist or doctor.

References (3)
  1. Ohkawa H, Ohishi N, Yagi K. Hydroxylation of the 7- and 8-methyl groups of riboflavin by the microsomal electron transfer system of rat liver. J Biol Chem 1983;258:5629-33.. DOI
  2. Hamajima S, Ono S, Hirano H, Obara K. Induction of the FAD synthetase system in rat liver by phenobarbital administration. Int J Vit Nutr Res 1979;49:59-63..
  3. Shargel L, Mazel P. Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat. Biochem Pharmacol. 1973;22(19):2365-73. PubMed

Full nutrient report for Dehydrocholic Acid, Homatropine Methylbromide, Phenobarbital →

Dicyclomine, Phenobarbital

Insufficient Evidence

Brand names include Bentyl w/ Pb

Phenobarbital might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Some evidence in animals suggests that phenobarbital induces metabolism of riboflavin in the liver. Levels of the active form of riboflavin, flavin adenine dinucleotide (FAD), are increased in the liver and levels of a hydroxylated metabolite are increased in the urine. Also, some animal research suggests that phenobarbital does not significantly affect the content of flavin in the liver.
Taking Dicyclomine, Phenobarbital? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin, eyes, and nerves working well. Animal studies suggest phenobarbital may cause the liver to break down riboflavin faster than usual, which could nudge active riboflavin levels lower, but research in humans is limited and the two studies point in opposite directions. With an 'Insufficient Evidence' rating, this is more of an open question than a proven concern, so most people on phenobarbital do not need to act on this right now. That said, if you take phenobarbital long term, it is worth mentioning to your pharmacist or doctor at your next visit.

References (3)
  1. Ohkawa H, Ohishi N, Yagi K. Hydroxylation of the 7- and 8-methyl groups of riboflavin by the microsomal electron transfer system of rat liver. J Biol Chem 1983;258:5629-33.. DOI
  2. Hamajima S, Ono S, Hirano H, Obara K. Induction of the FAD synthetase system in rat liver by phenobarbital administration. Int J Vit Nutr Res 1979;49:59-63..
  3. Shargel L, Mazel P. Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat. Biochem Pharmacol. 1973;22(19):2365-73. PubMed

Full nutrient report for Dicyclomine, Phenobarbital →

Doxorubicin

Insufficient Evidence

Brand names include Doxil, Adriamycin, Rubex

Doxorubicin might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Preliminary evidence indicates that doxorubicin interacts with riboflavin by forming complexes, competing for tissue binding sites, reducing conversion to flavin adenine dinucleotide (FAD, the active form of riboflavin), and increasing urinary excretion. These effects may contribute to cardiac and muscle toxicity associated with doxorubicin, but data in humans are lacking.
Taking Doxorubicin? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin is a B vitamin your body uses to turn food into energy and keep muscles and organs running properly. Early laboratory research suggests doxorubicin may interfere with riboflavin in a few ways, including binding to it directly, competing for the same spots in body tissues, slowing its conversion to the active form your cells can use, and nudging the kidneys to excrete more of it. That said, we are talking about preliminary, lab-level findings with very little human data, so no one knows yet whether this actually matters clinically. If you are on doxorubicin and curious whether any of this applies to you, it is worth raising with your oncologist or pharmacist.

References (4)
  1. Pinto J, Raiczyk GB, Huang YP, Rivlin RS. New approaches to the possible prevention of side effects of chemotherapy by nutrition. Cancer 1986;58:1911-4.. PubMed
  2. Ogura R, Ueta H, Hino Y, et al. Riboflavin deficiency caused by treatment with adriamycin. J Nutr Sci Vitaminol 1991;37:473-7.. PubMed
  3. Raiczyk GB, Pinto J. Inhibition of flavin metabolism by adriamycin in skeletal muscle. Biochem Pharmacol 1988;37:1741-4.. PubMed
  4. Pinto J, Huang YP, Pelliccione N, Rivlin RS. Adriamycin inhibits flavin synthesis in heart: possible relation to cardiotoxicity of anthracyclines (abstract). Clin Res 1983;31;467A.

Full nutrient report for Doxorubicin →

Brand names include Lufyllin-EPG

Phenobarbital might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Some evidence in animals suggests that phenobarbital induces metabolism of riboflavin in the liver. Levels of the active form of riboflavin, flavin adenine dinucleotide (FAD), are increased in the liver and levels of a hydroxylated metabolite are increased in the urine. Also, some animal research suggests that phenobarbital does not significantly affect the content of flavin in the liver.
Taking Dyphylline, Ephedrine, Guaifenesin, Phenobarbital? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin is a B vitamin your body uses to convert food into energy and keep cells working properly. The phenobarbital in this combination may prompt the liver to process riboflavin faster than usual, which some animal research suggests could affect active riboflavin levels. That said, the evidence here is quite limited and conflicting, so right now this is more of an open question than a proven concern. If you have been on this medication long-term, it is worth mentioning to your pharmacist or doctor at your next visit.

References (3)
  1. Ohkawa H, Ohishi N, Yagi K. Hydroxylation of the 7- and 8-methyl groups of riboflavin by the microsomal electron transfer system of rat liver. J Biol Chem 1983;258:5629-33.. DOI
  2. Hamajima S, Ono S, Hirano H, Obara K. Induction of the FAD synthetase system in rat liver by phenobarbital administration. Int J Vit Nutr Res 1979;49:59-63..
  3. Shargel L, Mazel P. Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat. Biochem Pharmacol. 1973;22(19):2365-73. PubMed

Full nutrient report for Dyphylline, Ephedrine, Guaifenesin, Phenobarbital →

Brand names include Mudrane GG

Phenobarbital might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Some evidence in animals suggests that phenobarbital induces metabolism of riboflavin in the liver. Levels of the active form of riboflavin, flavin adenine dinucleotide (FAD), are increased in the liver and levels of a hydroxylated metabolite are increased in the urine. Also, some animal research suggests that phenobarbital does not significantly affect the content of flavin in the liver.
Taking Ephedrine, Guaifenesin, Phenobarbital, Theophylline? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body convert food into energy and keeps your skin, eyes, and nerves working well. Animal studies suggest phenobarbital may speed up how the liver processes riboflavin, potentially shifting levels of its active form, though results across studies have been mixed. Because the evidence here is rated insufficient, we simply do not know whether this matters in people. If you have been on phenobarbital long-term and are curious, it is worth bringing up with your pharmacist or doctor at your next visit.

References (3)
  1. Ohkawa H, Ohishi N, Yagi K. Hydroxylation of the 7- and 8-methyl groups of riboflavin by the microsomal electron transfer system of rat liver. J Biol Chem 1983;258:5629-33.. DOI
  2. Hamajima S, Ono S, Hirano H, Obara K. Induction of the FAD synthetase system in rat liver by phenobarbital administration. Int J Vit Nutr Res 1979;49:59-63..
  3. Shargel L, Mazel P. Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat. Biochem Pharmacol. 1973;22(19):2365-73. PubMed

Full nutrient report for Ephedrine, Guaifenesin, Phenobarbital, Theophylline →

Brand names include Quadrinal, Mudrane

Phenobarbital might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Some evidence in animals suggests that phenobarbital induces metabolism of riboflavin in the liver. Levels of the active form of riboflavin, flavin adenine dinucleotide (FAD), are increased in the liver and levels of a hydroxylated metabolite are increased in the urine. Also, some animal research suggests that phenobarbital does not significantly affect the content of flavin in the liver.
Taking Ephedrine, Phenobarbital, Potassium Iodide, Theophylline? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your cells turn food into energy and keeps your skin, nerves, and eyes healthy. Animal studies have suggested that phenobarbital may prompt the liver to process riboflavin faster than usual, which could theoretically affect active riboflavin levels in the body. That said, the research is limited to animal data and the findings are mixed, so the real-world impact in people is simply not known. Most patients on phenobarbital do not need to act on this right now, but mentioning it to your pharmacist or doctor at your next visit is always reasonable.

References (3)
  1. Ohkawa H, Ohishi N, Yagi K. Hydroxylation of the 7- and 8-methyl groups of riboflavin by the microsomal electron transfer system of rat liver. J Biol Chem 1983;258:5629-33.. DOI
  2. Hamajima S, Ono S, Hirano H, Obara K. Induction of the FAD synthetase system in rat liver by phenobarbital administration. Int J Vit Nutr Res 1979;49:59-63..
  3. Shargel L, Mazel P. Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat. Biochem Pharmacol. 1973;22(19):2365-73. PubMed

Full nutrient report for Ephedrine, Phenobarbital, Potassium Iodide, Theophylline →

Brand names include Tedral

Phenobarbital might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Some evidence in animals suggests that phenobarbital induces metabolism of riboflavin in the liver. Levels of the active form of riboflavin, flavin adenine dinucleotide (FAD), are increased in the liver and levels of a hydroxylated metabolite are increased in the urine. Also, some animal research suggests that phenobarbital does not significantly affect the content of flavin in the liver.
Taking Ephedrine, Phenobarbital, Theophylline? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin is a B vitamin your body uses to convert food into energy and keep cells working properly. Animal studies have suggested that phenobarbital may prompt the liver to process riboflavin more quickly, potentially shifting its active form around, but other animal research found no meaningful change at all. Because the evidence comes only from animal studies and points in different directions, we simply do not know whether this matters in people. If you have been on phenobarbital long-term and have questions about your nutritional status, it is worth a quick conversation with your pharmacist or doctor.

References (3)
  1. Ohkawa H, Ohishi N, Yagi K. Hydroxylation of the 7- and 8-methyl groups of riboflavin by the microsomal electron transfer system of rat liver. J Biol Chem 1983;258:5629-33.. DOI
  2. Hamajima S, Ono S, Hirano H, Obara K. Induction of the FAD synthetase system in rat liver by phenobarbital administration. Int J Vit Nutr Res 1979;49:59-63..
  3. Shargel L, Mazel P. Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat. Biochem Pharmacol. 1973;22(19):2365-73. PubMed

Full nutrient report for Ephedrine, Phenobarbital, Theophylline →

Brand names include Bellaspas, Bellamine, Eperbel-S

Phenobarbital might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Some evidence in animals suggests that phenobarbital induces metabolism of riboflavin in the liver. Levels of the active form of riboflavin, flavin adenine dinucleotide (FAD), are increased in the liver and levels of a hydroxylated metabolite are increased in the urine. Also, some animal research suggests that phenobarbital does not significantly affect the content of flavin in the liver.
Taking Ergotamine, Belladonna, Phenobarbital? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin is a B vitamin your body depends on for turning food into energy and keeping cells working properly. The phenobarbital component of this combination may prompt the liver to process riboflavin differently, potentially affecting levels of its active form. That said, the research here is mostly from animal studies and the findings are mixed, so the real-world impact for people is genuinely unknown. If you have been taking this medication long term, it is worth mentioning to your pharmacist or doctor, but there is no established reason to be alarmed right now.

References (3)
  1. Ohkawa H, Ohishi N, Yagi K. Hydroxylation of the 7- and 8-methyl groups of riboflavin by the microsomal electron transfer system of rat liver. J Biol Chem 1983;258:5629-33.. DOI
  2. Hamajima S, Ono S, Hirano H, Obara K. Induction of the FAD synthetase system in rat liver by phenobarbital administration. Int J Vit Nutr Res 1979;49:59-63..
  3. Shargel L, Mazel P. Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat. Biochem Pharmacol. 1973;22(19):2365-73. PubMed

Full nutrient report for Ergotamine, Belladonna, Phenobarbital →

Hyoscyamine, Phenobarbital

Insufficient Evidence

Brand names include Levsin Pb, Levsinex Pb Timecaps

Phenobarbital might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Some evidence in animals suggests that phenobarbital induces metabolism of riboflavin in the liver. Levels of the active form of riboflavin, flavin adenine dinucleotide (FAD), are increased in the liver and levels of a hydroxylated metabolite are increased in the urine. Also, some animal research suggests that phenobarbital does not significantly affect the content of flavin in the liver.
Taking Hyoscyamine, Phenobarbital? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) is something your body uses to convert food into energy and keep cells working properly. There is animal research suggesting phenobarbital may cause the liver to process riboflavin faster than usual, potentially affecting active riboflavin levels, but studies in animals have actually shown mixed results. The honest answer right now is that nobody knows how much this matters in people taking the medication long-term. If you have concerns, it is worth bringing up with your pharmacist or doctor at your next visit.

References (3)
  1. Ohkawa H, Ohishi N, Yagi K. Hydroxylation of the 7- and 8-methyl groups of riboflavin by the microsomal electron transfer system of rat liver. J Biol Chem 1983;258:5629-33.. DOI
  2. Hamajima S, Ono S, Hirano H, Obara K. Induction of the FAD synthetase system in rat liver by phenobarbital administration. Int J Vit Nutr Res 1979;49:59-63..
  3. Shargel L, Mazel P. Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat. Biochem Pharmacol. 1973;22(19):2365-73. PubMed

Full nutrient report for Hyoscyamine, Phenobarbital →

Phenobarbital

Insufficient Evidence

Brand names include Solfoton, Luminal

Phenobarbital might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Some evidence in animals suggests that phenobarbital induces metabolism of riboflavin in the liver. Levels of the active form of riboflavin, flavin adenine dinucleotide (FAD), are increased in the liver and levels of a hydroxylated metabolite are increased in the urine. Also, some animal research suggests that phenobarbital does not significantly affect the content of flavin in the liver.
Taking Phenobarbital? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin is a B vitamin your body uses to convert food into energy and keep cells working properly. There is some animal research suggesting phenobarbital may speed up how the liver processes riboflavin, potentially affecting its active form, but this has not been clearly shown to matter in people. Given the insufficient evidence rating, this is more of an open question than a proven concern, so most patients taking phenobarbital do not need to act on this right now. If you are curious or have been on this medication long-term, it is worth a quick conversation with your pharmacist or doctor.

References (3)
  1. Ohkawa H, Ohishi N, Yagi K. Hydroxylation of the 7- and 8-methyl groups of riboflavin by the microsomal electron transfer system of rat liver. J Biol Chem 1983;258:5629-33.. DOI
  2. Hamajima S, Ono S, Hirano H, Obara K. Induction of the FAD synthetase system in rat liver by phenobarbital administration. Int J Vit Nutr Res 1979;49:59-63..
  3. Shargel L, Mazel P. Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat. Biochem Pharmacol. 1973;22(19):2365-73. PubMed

Full nutrient report for Phenobarbital →

Phenobarbital, Phenytoin

Insufficient Evidence

Brand names include Dilantin with PB

Phenobarbital might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Some evidence in animals suggests that phenobarbital induces metabolism of riboflavin in the liver. Levels of the active form of riboflavin, flavin adenine dinucleotide (FAD), are increased in the liver and levels of a hydroxylated metabolite are increased in the urine. Also, some animal research suggests that phenobarbital does not significantly affect the content of flavin in the liver.
Taking Phenobarbital, Phenytoin? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin, which your body uses to convert food into energy and keep tissues healthy, may be processed differently in the liver when you take phenobarbital. Some animal studies suggest phenobarbital speeds up how the liver handles riboflavin, potentially shifting its active form. That said, the research is limited and conflicting, so the real-world impact on people is simply not known yet. If you have been on these medications long-term and have concerns, it is worth a quick conversation with your pharmacist or doctor.

References (3)
  1. Ohkawa H, Ohishi N, Yagi K. Hydroxylation of the 7- and 8-methyl groups of riboflavin by the microsomal electron transfer system of rat liver. J Biol Chem 1983;258:5629-33.. DOI
  2. Hamajima S, Ono S, Hirano H, Obara K. Induction of the FAD synthetase system in rat liver by phenobarbital administration. Int J Vit Nutr Res 1979;49:59-63..
  3. Shargel L, Mazel P. Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat. Biochem Pharmacol. 1973;22(19):2365-73. PubMed

Full nutrient report for Phenobarbital, Phenytoin →

Phenobarbital, Sodium Nitrate

Insufficient Evidence

Brand names include Soniphen

Phenobarbital might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Some evidence in animals suggests that phenobarbital induces metabolism of riboflavin in the liver. Levels of the active form of riboflavin, flavin adenine dinucleotide (FAD), are increased in the liver and levels of a hydroxylated metabolite are increased in the urine. Also, some animal research suggests that phenobarbital does not significantly affect the content of flavin in the liver.
Taking Phenobarbital, Sodium Nitrate? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin is a B vitamin your body uses to convert food into energy and keep cells working properly. There is some animal research suggesting phenobarbital may prompt the liver to process riboflavin faster than usual, potentially affecting levels of its active form, but the animal findings are actually mixed and no one has clearly shown this matters in people. Because the evidence is rated insufficient, most patients taking phenobarbital do not need to act on this right now. If you have concerns, it is worth bringing up with your pharmacist or doctor at your next visit.

References (3)
  1. Ohkawa H, Ohishi N, Yagi K. Hydroxylation of the 7- and 8-methyl groups of riboflavin by the microsomal electron transfer system of rat liver. J Biol Chem 1983;258:5629-33.. DOI
  2. Hamajima S, Ono S, Hirano H, Obara K. Induction of the FAD synthetase system in rat liver by phenobarbital administration. Int J Vit Nutr Res 1979;49:59-63..
  3. Shargel L, Mazel P. Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat. Biochem Pharmacol. 1973;22(19):2365-73. PubMed

Full nutrient report for Phenobarbital, Sodium Nitrate →

Probenecid

Insufficient Evidence

Brand names include Benemid, Benuryl, Probecid

Probenecid might reduce active riboflavin levels; however, the clinical significance of this is unclear.
In humans, probenecid reduces renal tubular secretion and total urinary excretion of both supplemental and dietary riboflavin. It may also reduce the active intestinal absorption mechanism for riboflavin. After single doses of probenecid, the effect on renal excretion predominates, and plasma riboflavin levels are increased. The effect of prolonged probenecid therapy on riboflavin balance, and therefore the clinical significance, is not known.
Taking Probenecid? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin (vitamin B2) helps your body turn food into energy and keeps your skin, nerves, and red blood cells healthy. Probenecid appears to interfere with how your kidneys handle riboflavin, slowing the amount your body normally flushes out in urine, which actually causes riboflavin to build up in the blood rather than drop, at least after a single dose. What happens with long-term use is simply not known yet, so the evidence here is genuinely inconclusive. Most people taking probenecid do not need to worry about this, but if you have questions, your pharmacist or doctor is a great place to start.

References (3)
  1. Yanagawa N, Shih RN, Jo OD, Said HM. Riboflavin transport by isolated perfused rabbit renal proximal tubules. Am J Physiol Cell Physiol 2000;279:C1782-6.. PubMed
  2. Jusko WJ, Levy G. Effect of probenecid on riboflavin absorption and excretion in man. J Pharm Sci 1967;56:1145-9. PubMed
  3. Jusko WJ, Levy G, Yaffe SJ, Gorodischer R. Effect of probenecid on renal clearance of riboflavin in man.J Pharm Sci 1970;59:473-7. DOI

Full nutrient report for Probenecid →

Quinacrine

Insufficient Evidence

Brand names include Atabrine

Quinacrine might reduce active riboflavin levels; however, the clinical significance of this is unclear.
Quinacrine has structural similarities to riboflavin and can interfere with its conversion to the active form flavin adenine dinucleotide (FAD). It's suggested that this could lead to riboflavin deficiency in humans, but it may also contribute to the therapeutic effects of quinacrine against malaria. The clinical significance isn't known.
Taking Quinacrine? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Riboflavin is a B vitamin your body needs to produce energy and keep cells working properly. Quinacrine's chemical structure is similar enough to riboflavin that it may interfere with the step where your body converts riboflavin into its active, usable form. That said, the evidence here is genuinely thin, and researchers do not yet know whether this matters clinically for most people taking quinacrine. If you have concerns, it is worth bringing up with your pharmacist or doctor.

References (3)
  1. Hardman JG, Limbird LL, Molinoff PB, eds. Goodman and Gillman's The Pharmacological Basis of Therapeutics, 9th ed. New York, NY: McGraw-Hill, 1996.
  2. Raiczyk GB, Dutta P, Pinto J. Chlorpromazine and quinacrine inhibit flavin adenine dinucleotide biosynthesis in skeletal muscle. Physiologist 1985;28:322.
  3. Dutta P, Pinto J, Rivlin R. Antimalarial effects of riboflavin deficiency. Lancet 1985;2:1040-3. PubMed

Full nutrient report for Quinacrine →

Important

This tool is educational and is not a substitute for professional medical advice. An association is not a diagnosis and does not mean a deficiency will occur. Always talk to your pharmacist or healthcare provider before starting, stopping, or changing any medication or supplement.

Disclaimer: This checker finds which nutrients might be depleted by prescription or over-the-counter medications. Each nutrient depletion issue is rated based on clinical significance. Use your own professional judgment prior to making clinical decisions.

© 2026 Therapeutic Research Center Licensed records refresh weekly · last updated July 3, 2026.
Understand the basics

What drug-induced nutrient depletion means

Some medications can, over time, lower the levels of certain vitamins, minerals, or other nutrients — through reduced absorption, increased loss, or changes in how the body uses them.

Association is not deficiency

An entry here means a depletion has been reported or studied — not that it happens to everyone, or that you are deficient. Dose, duration, diet, and your own health all matter.

Evidence varies by pair

Some drug–nutrient links (like metformin and vitamin B12) are well studied; others rest on limited or preliminary research. Each entry shows the evidence rating from our licensed clinical database.

When to ask about labs

If you take an associated medication long-term, ask your healthcare provider whether monitoring is appropriate for you. Not everyone needs testing — your provider can weigh your dose, duration, and symptoms.

Don't self-supplement blindly

Supplements are not risk-free: some can interact with medications, and some (like potassium or magnesium) can be risky with kidney disease. Talk to your pharmacist before adding anything.

Never stop a medication over this

These medications are prescribed for good reasons, and the benefit usually far outweighs a manageable nutrient consideration. Any change belongs in a conversation with your prescriber.

Food first, usually

For many nutrients, a varied diet covers the gap. Each entry lists common food sources; a supplement is a decision to make with your pharmacist or provider, not a default.

Common questions

RIBOFLAVIN & medications: FAQs

Which medications can lower RIBOFLAVIN?
In our licensed clinical database, 225 medications have been associated with RIBOFLAVIN depletion, including Amikacin, Amitriptyline, Amitriptyline, Chlordiazepoxide and Amitriptyline, Perphenazine. Each entry above shows the evidence rating and the published details. An association is not a guarantee — dose, duration, diet, and your own health all matter.
I take one of these medications — am I deficient in RIBOFLAVIN?
Not necessarily. These entries describe reported associations, not certainties. Many people take these medications without developing a meaningful RIBOFLAVIN problem. If you take one long-term, the reasonable step is to ask your healthcare provider whether checking your RIBOFLAVIN status is appropriate for you.
Should I start a RIBOFLAVIN supplement?
Not without checking first. Supplements are not risk-free — some interact with medications, and for certain nutrients (like potassium or magnesium) supplementation can be genuinely risky with kidney disease or particular drug combinations. Food-first strategies and clinician-guided testing usually come before a supplement.
Where does this information come from?
The depletion records come from the Natural Medicines (Therapeutic Research Center) database — an evidence-graded clinical reference — and are displayed as published, with their citations. The plain-English education is written and reviewed by licensed HelloPharmacist pharmacists.

Wondering about your RIBOFLAVIN levels?

Ask a licensed pharmacist — free, no appointment needed.

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Sources

Sources & How We Checked

Medication associations with RIBOFLAVIN are evidence-graded and sourced from the Natural Medicines database, and are displayed as published with their citations.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.