Androsterone - Conjugated Estrogens, Methyltestosterone Interaction
Herbal: Androsterone
Also Known As: 3-Alpha-Hydroxy-17-Androstanone, Androsterone Undecanoate, Androkinine, Androtine
Drug: Conjugated Estrogens, Methyltestosterone
Brand names:
Premarin with Methyltestosterone
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Feb 10, 2024
Interaction Details
Conjugated Estrogens, Methyltestosterone is classified as belonging to the following category: Androgens
Androsterone, as an androgenic hormone, may interact with other androgenic drugs, such as testosterone, due to their similar mechanisms of action. Both androsterone and testosterone bind to androgen receptors in various tissues throughout the body, leading to similar physiological effects related to the development and maintenance of male secondary sexual characteristics. When taken together, these compounds can potentially amplify these effects, leading to an increased risk of androgenic side effects, such as acne, hair loss, and changes in libido. Additionally, combining androsterone with testosterone or other androgenic drugs may also affect hormone levels and balance in the body, potentially leading to hormonal imbalances or disruptions in the endocrine system.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Androsterone Overview
Androsterone, classified as an anabolic androgenic steroid under the United States Designer Anabolic Steroid Control Act (DASCA), is prohibited from being included in dietary supplements. This natural steroid hormone is produced in the adrenal glands, ovaries, and testes, and is a metabolite of testosterone and androstenedione. It contributes to the development of secondary sexual characteristics in males and is present in trace amounts in the urine and sweat of both genders. Known for its mild androgenic properties, androsterone helps maintain masculine traits and libido.
Androsterone - More Interactions
Androsterone interacts with 9 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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