Medication interaction hub

What Supplements Interact with Conjugated Estrogens, Methyltestosterone?

Conjugated Estrogens, Methyltestosterone brand name: Premarin with Methyltestosterone. Every interaction below applies to the brands too.

226 Interactions 6 Major 184 Moderate 36 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Conjugated Estrogens, Methyltestosterone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Conjugated Estrogens, Methyltestosterone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

If you take conjugated estrogens with methyltestosterone (Premarin with Methyltestosterone), a hormone combination used for menopausal symptoms, read the six major-rated entries here before adding any supplement. Most of the 226 ingredients on file change how your body handles the hormones themselves. More than a hundred affect the CYP3A4 enzyme that breaks them down, so grapefruit can push hormone levels up while St. John's wort can drive them low enough to lose the benefit. Dozens more, including heavy alcohol, add strain on a liver that is already processing an oral hormone product.

Another sixty ingredients act like estrogen on their own and can stack with or work against your prescription. The rest, 184 moderate and 36 minor in all, mostly echo these same themes at lower intensity, though the caffeine one may surprise you. Estrogen slows how you clear caffeine, so your usual coffee or tea can hit harder than expected.

— , Clinical Pharmacist · July 18, 2026

Major 6 Moderate 184 Minor 36 No known interaction 1,226

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Conjugated Estrogens, Methyltestosterone: Top Interactions at a Glance

The Conjugated Estrogens, Methyltestosterone supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 226 interacting ingredients — plus 1,226 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Conjugated Estrogens, Methyltestosterone Combinations Today

The Conjugated Estrogens, Methyltestosterone + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Hemp + Conjugated Estrogens, Methyltestosteronei

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.

Read the full interaction Minor Likelihood Possible Cordyceps + Conjugated Estrogens, Methyltestosteronei

Theoretically, concurrent use of cordyceps and testosterone might have additive effects.

Read the full interaction Moderate Likelihood Possible Bog Labrador Tea + Conjugated Estrogens, Methyltestosteronei

In vitro research shows that aqueous and ethanolic extracts of Bog Labrador tea leaves can increase the concentration of cytochrome P450 3A4 (CYP3A4) enzymes.

Read the full interaction Moderate Likelihood Possible Dhea + Conjugated Estrogens, Methyltestosteronei

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Pregnenolone + Conjugated Estrogens, Methyltestosteronei

Theoretically, taking pregnenolone might enhance the effects of estrogens.

Read the full interaction Minor Likelihood Possible Vitamin D + Conjugated Estrogens, Methyltestosteronei

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Conjugated Estrogens, Methyltestosterone

All 1,452 ingredients in our database, ranked by severity — 226 with a Conjugated Estrogens, Methyltestosterone interaction on file and 1,226 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Conjugated Estrogens, Methyltestosterone?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Hemp with Conjugated Estrogens, Methyltestosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.

Full Hemp + Conjugated Estrogens, Methyltestosterone answer

Can you take Cordyceps with Conjugated Estrogens, Methyltestosterone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concurrent use of cordyceps and testosterone might have additive effects.

Full Cordyceps + Conjugated Estrogens, Methyltestosterone answer

Can you take Bog Labrador Tea with Conjugated Estrogens, Methyltestosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that aqueous and ethanolic extracts of Bog Labrador tea leaves can increase the concentration of cytochrome P450 3A4...

Full Bog Labrador Tea + Conjugated Estrogens, Methyltestosterone answer

Can you take Dhea with Conjugated Estrogens, Methyltestosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Full Dhea + Conjugated Estrogens, Methyltestosterone answer

Can you take Pregnenolone with Conjugated Estrogens, Methyltestosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking pregnenolone might enhance the effects of estrogens.

Full Pregnenolone + Conjugated Estrogens, Methyltestosterone answer

Can you take Karaya Gum with Conjugated Estrogens, Methyltestosterone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Conjugated Estrogens, Methyltestosterone answer

Can you take L-arginine with Conjugated Estrogens, Methyltestosterone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of L-arginine and testosterone might have additive effects.

Full L-arginine + Conjugated Estrogens, Methyltestosterone answer

Can you take Marshmallow with Conjugated Estrogens, Methyltestosterone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Conjugated Estrogens, Methyltestosterone answer

Can you take Melatonin with Conjugated Estrogens, Methyltestosterone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, melatonin might increase levels of drugs metabolized by CYP3A4.

Full Melatonin + Conjugated Estrogens, Methyltestosterone answer

Can you take Passion Flower with Conjugated Estrogens, Methyltestosterone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, passion flower might decrease the effects of CYP3A4 substrates.

Full Passion Flower + Conjugated Estrogens, Methyltestosterone answer

Can you take Puravive with Conjugated Estrogens, Methyltestosterone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Puravive contains Panax ginseng.

Full Puravive + Conjugated Estrogens, Methyltestosterone answer

Can you take Sesame with Conjugated Estrogens, Methyltestosterone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, sesame might alter the transport of P-glycoprotein substrates.

Full Sesame + Conjugated Estrogens, Methyltestosterone answer

Can you take Vitamin D with Conjugated Estrogens, Methyltestosterone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Full Vitamin D + Conjugated Estrogens, Methyltestosterone answer

Can you take Xanthan Gum with Conjugated Estrogens, Methyltestosterone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Conjugated Estrogens, Methyltestosterone answer

Can you take Yohimbe with Conjugated Estrogens, Methyltestosterone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.

Full Yohimbe + Conjugated Estrogens, Methyltestosterone answer

Can you take Deer Velvet with Conjugated Estrogens, Methyltestosterone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, deer velvet might increase the effects and side effects of estrogens.

Full Deer Velvet + Conjugated Estrogens, Methyltestosterone answer

Can you take Gymnema with Conjugated Estrogens, Methyltestosterone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.

Full Gymnema + Conjugated Estrogens, Methyltestosterone answer

Can you take Humann Superbeets Heart Chews with Conjugated Estrogens, Methyltestosterone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Full Humann Superbeets Heart Chews + Conjugated Estrogens, Methyltestosterone answer

Can you take Jequirity with Conjugated Estrogens, Methyltestosterone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro research shows that jequirity extract inhibits CYP3A4 enzymes.

Full Jequirity + Conjugated Estrogens, Methyltestosterone answer

Can you take Mommy's Bliss Gripe Water with Conjugated Estrogens, Methyltestosterone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Mommy's Bliss Gripe Water contains fennel seed.

Full Mommy's Bliss Gripe Water + Conjugated Estrogens, Methyltestosterone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Conjugated Estrogens, Methyltestosterone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Conjugated Estrogens, Methyltestosterone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Conjugated Estrogens, Methyltestosterone sits in 9 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Conjugated Estrogens, Methyltestosterone through this category.

Estrogens 60 ingredients

Hormone-related medications. Supplements with hormone-like activity can add to or interfere with them.

60 of the supplement ingredients on this page reach Conjugated Estrogens, Methyltestosterone through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Conjugated Estrogens, Methyltestosterone through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Conjugated Estrogens, Methyltestosterone through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Conjugated Estrogens, Methyltestosterone through this category.

Testosterone 14 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

14 of the supplement ingredients on this page reach Conjugated Estrogens, Methyltestosterone through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Conjugated Estrogens, Methyltestosterone through this category.

Androgens 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Conjugated Estrogens, Methyltestosterone through this category.

Ethinyl Estradiol 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Conjugated Estrogens, Methyltestosterone through this category.

Related: does Conjugated Estrogens, Methyltestosterone deplete any nutrients?

Conjugated Estrogens, Methyltestosterone has 5 reported nutrient associations in the research literature — see the Conjugated Estrogens, Methyltestosterone nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Conjugated Estrogens, Methyltestosterone

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Conjugated Estrogens, Methyltestosterone.

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Pharmacist Counseling Corner

Conjugated Estrogens, Methyltestosterone & Supplements: Common Questions

What supplements interact with Conjugated Estrogens, Methyltestosterone?
In our interaction database, 226 supplement and herbal ingredients have an interaction with Conjugated Estrogens, Methyltestosterone on file — 6 rated major, 184 moderate, and 36 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which Conjugated Estrogens, Methyltestosterone supplement interactions are the most serious?
The 6 major-rated combinations — led by Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Conjugated Estrogens, Methyltestosterone?
That depends entirely on which supplement. The honest answer for Conjugated Estrogens, Methyltestosterone is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Premarin with Methyltestosterone have the same supplement interactions as Conjugated Estrogens, Methyltestosterone?
Yes — Premarin with Methyltestosterone all contain Conjugated Estrogens, Methyltestosterone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Conjugated Estrogens, Methyltestosterone deplete any vitamins or nutrients?
It might — Conjugated Estrogens, Methyltestosterone has 5 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Conjugated Estrogens, Methyltestosterone nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Conjugated Estrogens, Methyltestosterone and my other medications?
This page covers Conjugated Estrogens, Methyltestosterone against supplements and herbal ingredients. Checking Conjugated Estrogens, Methyltestosterone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.