Herb & supplement monograph

African Wild Potato Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how African Wild Potato interacts with medications. The heart of this page is the interaction list — every drug African Wild Potato is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what African Wild Potato is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

Check African Wild Potato against your medication

Add one medication

✓ Supplement

African Wild Potato

1 Your medication

Start typing any prescription or over-the-counter drug name.

Reviewed by licensed pharmacists Sourced from Natural Medicines

On this page

African Wild Potato Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant African Wild Potato drug interaction appears low for most people, since nearly every listed interaction is theoretical rather than confirmed in humans. None of the interactions are rated major, all carry a moderate rating, and each rests on lab or animal research rather than human studies.

Interactions deserving the most attention

The pairing most worth watching is with diabetes medications, because animal research suggests African Wild Potato may lower blood sugar, and an added drop could matter for someone whose glucose is tightly managed. The HIV drug indinavir also stands out, as lab and animal work suggest the herb could raise its levels in the body. Beyond these, nothing else rises above the general theoretical concern.

What the rest of the list means

The long list of medications reflects lab findings that African Wild Potato may slow the enzymes and transport proteins the body uses to clear many drugs, not proof that each combination is harmful. Notably, in one human study the herb did not change how the body handled efavirenz, a drug cleared by one of those enzymes, suggesting some predicted effects may not play out in people.

Check your medications against African Wild Potato

Based on HelloPharmacist’s African Wild Potato interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with African Wild Potato

1007 medications have a known interaction with African Wild Potato, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against African Wild Potato using our pharmacist-reviewed interaction data.

AI summaries are generated from our African Wild Potato interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact African Wild Potato combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs African Wild Potato affects

Every type of medication (drug category) African Wild Potato is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 9 drug categories African Wild Potato interacts with

Antidiabetes DrugsCytochrome P450 1a2 (cyp1a2) SubstratesCytochrome P450 2b6 (cyp2b6) SubstratesCytochrome P450 2c8 (cyp2c8) SubstratesCytochrome P450 2c9 (cyp2c9) SubstratesCytochrome P450 3a4 (cyp3a4) SubstratesIndinavir (crixivan)Organic Anion Transporter 1 (oat1) SubstratesOrganic Anion Transporter 3 (oat3) Substrates

Antidiabetes Drugs

Evidence from animal research suggests that African wild potato lowers blood glucose levels. So far, this effect has not been shown in humans. Theoretically, concomitant use of African wild potato and antidiabetes drugs might increase the risk of hypoglycemia. Dose adjustments might be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.