Drug & supplement interaction

African Wild Potato + Necitumumab

Necitumumab brand name: Portrazza.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between African Wild Potato and Necitumumab in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

African Wild Potato and Necitumumab

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Necitumumab and African Wild Potato in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

African Wild Potato safety at a glance

African Wild Potat... overall Use caution Limited human safety data and unclear effective doses mean it should be used cautiously.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid No reliable safety data, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Necitumumab and African Wild Potato? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

African Wild Potato Does Interact With Other Medications

African Wild Potato has 1,005 moderate known drug interactions in our database — Necitumumab isn’t one of them. If you take anything else, check it against the full list below.

Moderate 1,005 No known interaction 1,825 (incl. Necitumumab)
Taking anything else?

Check Another of Your Medications Against African Wild Potato

Covers the 2,830 medications we’ve checked against African Wild Potato. Pick one to open its full report.

What to actually watch for

What African Wild Potato Itself Has Been Linked To

This is not an interaction — nothing below involves Necitumumab. It is the side-effect record for African Wild Potato on its own, from the licensed Natural Medicines monograph. If something new turns up after you add African Wild Potato, this list is the first place to look.

  • A change in sex drive / Erection problems Additional detail

    “There is limited information available about the adverse effects of African wild potato. Some studies have evaluated constituents isolated from African wild potato, including beta-sitosterol and hypoxoside. Side effects reported with beta-sitosterol include nausea, indigestion, gas, diarrhea, constipation, erectile dysfunction, and loss of libido.”

    African Wild Potato · Natural Medicines adverse-effect record, reported in anxiety.

    4 sources cited
    1. 5327. Berges RR, Windeler J, Trampisch HJ, et al. Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. Lancet 1995;345:1529-32.
    2. 5328. Klippel KF, Hiltl DM, Schipp B. A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. Br J Urol 1997;80:427-32.
    3. 5942. Berges RR, Windeler J, Trampisch HJ, et al. Randomized, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Lancet 1995;345:1529-32.
    4. 13584. Smit BJ, Albrecht CF, Liebenberg RW, et al A phase I trial of hypoxoside as an oral prodrug for cancer therapy--absence of toxicity. S Afr Med J 1995;85:865-70.

    “Orally, the beta-sitosterol constituent of African wild potato has been reported to cause erectile dysfunction and loss of libido.”

    African Wild Potato · Natural Medicines adverse-effect record, reported in erectile dysfunction (ed).

    1 source cited
    1. 5942. Berges RR, Windeler J, Trampisch HJ, et al. Randomized, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Lancet 1995;345:1529-32.
  • Anxiety or restlessness Additional detail

    “Orally, hypoxoside, an African wild potato constituent, has been reported to cause anxiety in one small, uncontrolled study.”

    African Wild Potato · Natural Medicines adverse-effect record, reported in anxiety.

    1 source cited
    1. 13584. Smit BJ, Albrecht CF, Liebenberg RW, et al A phase I trial of hypoxoside as an oral prodrug for cancer therapy--absence of toxicity. S Afr Med J 1995;85:865-70.
  • Stomach upset / Constipation / Diarrhea / Vomiting / Nausea Additional detail

    “Orally, specific beta-sitosterol extracts from African wild potato (Azuprostat, Harzol) can cause nausea, indigestion, gas, diarrhea, or constipation. Hypoxoside, an African wild potato constituent, has been reported to cause nausea, vomiting, and diarrhea in one small, uncontrolled study.”

    African Wild Potato · Natural Medicines adverse-effect record, reported in constipation.

    3 sources cited
    1. 5327. Berges RR, Windeler J, Trampisch HJ, et al. Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. Lancet 1995;345:1529-32.
    2. 5328. Klippel KF, Hiltl DM, Schipp B. A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. Br J Urol 1997;80:427-32.
    3. 13584. Smit BJ, Albrecht CF, Liebenberg RW, et al A phase I trial of hypoxoside as an oral prodrug for cancer therapy--absence of toxicity. S Afr Med J 1995;85:865-70.

Everything above comes from the Natural Medicines adverse-effect record for African Wild Potato — expand a row for the licensed statement it rests on. We haven’t matched Necitumumab to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Necitumumab.

Overlapping uses

What Necitumumab Is Prescribed For, and What African Wild Potato Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Necitumumab is a prescription medicine with approved uses on its FDA label. African Wild Potato is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

African Wild Potato has been studied for:

  • Lung cancer studied, not established African Wild Potato has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    African Wild Potato for lung cancer

    A very small clinical study in patients with lung cancer shows that taking hypoxoside, a constituent of African wild potato extract, does not seem to prolong survival when compared with historical control. The validity of these findings is limited by the small study size and lack of a control group.

    1 source cited
    1. 13584. Smit BJ, Albrecht CF, Liebenberg RW, et al A phase I trial of hypoxoside as an oral prodrug for cancer therapy--absence of toxicity. S Afr Med J 1995;85:865-70.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Necitumumab on your own; if you are taking African Wild Potato for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

One more smart check

Taking African Wild Potato as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing African Wild Potato, each one broken down to its full ingredient list — and combination products often carry several ingredients besides African Wild Potato. Even though African Wild Potato itself has no known interaction with Necitumumab, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where African Wild Potato and Necitumumab Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement African Wild Potato
Top half

#496 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Necitumumab
Steady interest

#1,970 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every African Wild Potato reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The African Wild Potato and Necitumumab records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About African Wild Potato

What is African Wild Potato?

  • Immune support
  • Prostate and urinary symptoms
  • Inflammation
  • General tonic/wellness
  • Skin conditions

African Wild Potato (Hypoxis hemerocallidea) is a southern African plant traditionally used as a tonic and for immune, prostate, and inflammatory complaints. Human evidence for these uses is very limited, and safety—especially during pregnancy, breastfeeding, or with serious illness—is not well established. Talk to a pharmacist or doctor before using it.

Hypoxis hemerocallidea · Hypoxidaceae · Corm (underground tuber/rootstock) · Capsules, tablets, tinctures, dried corm extracts, traditional decoctions

An interaction check asks whether these two react with each other — it does not ask whether African Wild Potato is a good idea for someone in your situation. Here is what our African Wild Potato record says about it on its own.

African Wild Potato: dosing

There is no well-established, standardized dose for African Wild Potato. Products vary widely in strength and in how they are prepared, so it is hard to compare one to another.If you choose to use it, follow the directions on the product label and do not exceed them. A pharmacist can help you review a specific product, check for quality concerns, and make sure it is appropriate for you. Choose products from reputable manufacturers, since supplement quality is not tightly regulated.

From our African Wild Potato monograph — the full record covers uses, side effects and every documented interaction.

Read the full African Wild Potato monograph & all interactions
Medication

About Necitumumab Injection

What Is Necitumumab Injection Used For?

Brand name: Portrazza

  • Necitumumab injection is used with gemcitabine (Gemzar) and cisplatin to treat a certain type of non-small-cell lung cancer (NSCLC) that has spread to other parts of the body. Necitumumab injection is in a class of medications called monoclonal antibodies. It works by helping your immune system to slow or stop the growth of cancer cells.

See full Necitumumab Injection drug information
Keep checking

Other Drugs & African Wild Potato

Browse every other medication we’ve checked against African Wild Potato — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
1,005Moderate
0Minor
1,824No known interaction
1,005 Moderate 1,824 No interaction
Moderate

1,005 interactions

Showing 60 of 1,005 moderate interactions — see all 1,005 on the African Wild Potato page.

No interaction 1,824 drugs checked — show the list

We also checked African Wild Potato against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,824 medications checked with no known interaction — see the full African Wild Potato list.

See the full African Wild Potato interactions page
See every supplement checked against Necitumumab, ranked by severity
Evidence & sources

African Wild Potato References

The 10 references that drive our African Wild Potato monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Berges RR, Windeler J, Trampisch HJ, et al. Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. Lancet 1995;345:1529-32.
  2. Klippel KF, Hiltl DM, Schipp B. A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. Br J Urol 1997;80:427-32.
  3. Berges RR, Windeler J, Trampisch HJ, et al. Randomized, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Lancet 1995;345:1529-32.
  4. Berges RR, Kassen A, Senge T. Treatment of symptomatic benign prostatic hyperplasia with beta-sitosterol: an 18-month follow-up. BJU Int 2000;85:842-6.
  5. Mahomed IM, Ojewole JA. Hypoglycemic effect of Hypoxis hemerocallidea corm (African potato) aqueous extract in rats. Methods Find Exp Clin Pharmacol 2003;25:617-23. PubMed
  6. Smit BJ, Albrecht CF, Liebenberg RW, et al A phase I trial of hypoxoside as an oral prodrug for cancer therapy--absence of toxicity. S Afr Med J 1995;85:865-70.
  7. Wilt TJ, Ishani A, Rutks I, et al. Phytotherapy for benign prostatic hyperplasia. Public Health Nutr 2000;3(4A):459-472. PubMed
  8. Jalloh MA, Gregory PJ, Hein D, et al. Dietary supplement interactions with antiretrovirals: a systematic review. Int J STD AIDS. 2017 Jan;28(1):4-15. PubMed
  9. Fasinu PS, Gutmann H, Schiller H, Bouic PJ, Rosenkranz B. The potential of Hypoxis hemerocallidea for herb-drug interaction. Pharm Biol. 2013 Dec;51(12):1499-507.
  10. Havenga K, Abay E, Wiesner L, Viljoen A, Steyn D, Hamman J. The in vitro and in vivo effects of Hypoxis hemerocallidea on indinavir pharmacokinetics: modulation of efflux. Planta Med. 2018;84(12-13):895-901. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking African Wild Potato and Necitumumab Together: Common Questions

Is it safe to take African Wild Potato with Necitumumab?
We do not list a known interaction between African Wild Potato and Necitumumab. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are African Wild Potato and Necitumumab used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for African Wild Potato in each. That is a conversation for your prescriber, especially if Necitumumab is being adjusted to a target.
Does African Wild Potato interact with any other medications?
Yes. African Wild Potato has 1,005 documented drug interactions in our database — Necitumumab is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

African Wild Potato monograph Uses, safety profile, and every drug interaction in one place Necitumumab Injection drug information The full plain-English guide to this medication Necitumumab supplement interactions Every supplement checked against Necitumumab, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 10 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Necitumumab and African Wild Potato?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.