Herb & supplement monograph

Avocado Sugar Extract Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated June 2026
What is this page for?

First and foremost: how Avocado Sugar Extract interacts with medications. The heart of this page is the interaction list — every drug Avocado Sugar Extract is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Avocado Sugar Extract is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Avocado Sugar Extract Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Avocado Sugar Extract drug interaction appears low for most people. Every interaction on record is rated moderate, and all of them trace back to a single theoretical concern rather than documented problems in people.

Interactions deserving the most attention

The one area that deserves real attention is diabetes medications, including insulin, metformin, glyburide, glimepiride, pioglitazone, and rosiglitazone. In theory, avocado sugar extract might raise blood sugar and work against these medicines, which matters because blood sugar control depends on keeping doses well matched to need. That said, this concern comes from limited, lower-grade evidence, not from well-controlled human studies, so it is a reason for awareness rather than alarm.

What the rest of the list means

Although dozens of medications appear on the interaction list, they all belong to this one category, so the number looks bigger than the actual concern. The predicted effect on blood sugar is theoretical at this point and has not been confirmed to cause meaningful changes in people. For anyone not taking a diabetes medicine, the data shows no other flagged interactions.

Check your medications against Avocado Sugar Extract

Based on HelloPharmacist’s Avocado Sugar Extract interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Avocado Sugar Extract

86 medications have a known interaction with Avocado Sugar Extract, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
AcarboseGlucobay, Prandase, Precose› AcetohexamideDymelor› AlbiglutideTanzeum› AlogliptinNesina› Alogliptin, MetforminKazano› Alogliptin, PioglitazoneOseni› Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi› CanagliflozinInvokana› Canagliflozin, MetforminInvokamet› Canagliflozin, Metformin HydrochlorideInvokamet XR› ChlorpropamideChlorpropam, Diabinese› DapagliflozinFarxiga› Dapagliflozin Propanediol, MetforminXigduo XR› Dapagliflozin Propanediol, Saxagliptin HydrochlorideQtern› Dapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR› Dasiglucagon HydrochlorideZegalogue› DulaglutideTrulicity› EmpagliflozinJardiance› Empagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR› Empagliflozin, MetforminSynjardy› Empagliflozin, Metformin HydrochlorideSynjardy XR› ErtugliflozinSteglatro› Ertugliflozin, Metformin HydrochlorideSegluromet› ExenatideBydureon, Byetta› Exenatide SyntheticBydureon BCISE› GliclazideDiamicron› GlimepirideAmaryl› GlipizideGlucotrol, Glucotrol XL› Glipizide, MetforminMetaglip› GlucagonBaqsimi, Glucagon›
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Avocado Sugar Extract combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Avocado Sugar Extract affects

Every type of medication (drug category) Avocado Sugar Extract is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Avocado Sugar Extract interacts with
Antidiabetes Drugs
Antidiabetes Drugs

Theoretically, avocado sugar extract might increase blood glucose levels, and decrease the effects of antidiabetic agents. Dose adjustments to diabetes medications might be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.

Likelihood Possible Evidence D
Monograph

Avocado Sugar Extract: Uses, Safety & Side Effects

Medically reviewed by · Reviewed June 2026 ·
The bottom line

Avocado sugar extract is a source of D-mannoheptulose, an unusual sugar studied mainly in laboratory and animal research for its possible effects on glucose metabolism. Human evidence is very limited, so it should not be relied on to treat diabetes or any condition. Talk with your pharmacist or doctor before using it, especially if you have blood sugar concerns.

Scientific name
Persea americana
Family
Lauraceae
Part used
Fruit (avocado pulp)
Common forms
Capsules, powders, and standardized extracts; sometimes included in supplement blends
People commonly use it for
  • Blood sugar support
  • Weight management
  • Healthy aging/longevity interest
  • Metabolic support
  • Athletic/animal supplement formulas

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallLimited data

Human safety data are very limited, so its long-term safety is not well established.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Avocado sugar extract is made from the fruit of the avocado plant (Persea americana). Avocados grow on trees in warm, tropical, and subtropical regions around the world and are widely eaten as food.

The extract is valued because avocado is one of the few natural sources of a rare seven-carbon sugar called D-mannoheptulose. This compound is the main reason the extract is studied. You may see it sold as a capsule, powder, or as an ingredient in metabolic or weight-management supplement blends, and it has also been explored in animal (pet) nutrition products.

How it works

The active compound, D-mannoheptulose, is a seven-carbon sugar that behaves differently from ordinary sugars like glucose. In laboratory studies, it can interfere with an early step in glucose breakdown by affecting an enzyme (hexokinase) that normally "tags" glucose so the cell can use it.

Because of this, researchers have observed that D-mannoheptulose may reduce glucose-driven insulin release from pancreatic cells, slow glucose use in liver cells, and lower lactate formation in some blood cells in test settings. A chemical derivative, D-mannoheptulose hexa-acetate, has been studied for blocking the phosphorylation of glucose.

It is important to understand these mechanisms come mostly from cell and animal experiments. How meaningfully they apply to humans taking a supplement is not well understood.

Effectiveness

Does Avocado Sugar Extract work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 1 use evaluated
1 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Avocado Sugar Extract, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 1 condition — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Obesity
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral avocado sugar extract is beneficial in patients with obesity.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Avocado is commonly eaten as a food and is generally well tolerated. However, a concentrated extract is different from eating avocado, and there is limited human safety information about taking it as a supplement over time.

People with diabetes or low blood sugar should be especially careful, since the extract is studied for effects on glucose and insulin. If you have a blood sugar condition, check with your doctor or pharmacist before using it and monitor your levels closely.

People with a latex-fruit allergy or avocado allergy should avoid it. Because safety data are lacking, those who are pregnant or breastfeeding should avoid it. Always tell your healthcare provider about any supplement you are considering.

Side effects

Because human studies are limited, the full side-effect profile is not well known. Possible effects could include digestive upset such as stomach discomfort, nausea, or changes in bowel habits, as can happen with many supplements.

People allergic to avocado may have allergic reactions, which in rare cases can be serious. Because of the possible effect on blood sugar, watch for symptoms of low blood sugar (such as shakiness, sweating, dizziness, or confusion), especially if you have diabetes. Stop using it and seek medical care if you have a severe or unexpected reaction.

Dosing

There is no established standardized dose for avocado sugar extract or D-mannoheptulose in humans. Products vary widely in how much extract they contain and how it is standardized.

If you choose to use it, follow the directions on the product label and do not exceed them. Because the research is early and the right amount is unknown, it is best to check with a pharmacist or doctor first, especially if you take other medicines or have a health condition.

Pregnancy & Breastfeeding

Avocado Sugar Extract & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Avocado Sugar Extract & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 1 references that drive our Avocado Sugar Extract monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Shaw PE, Wilson CW 3rd, Knight RJ Jr. High-performance liquid chromatographic analysis of D-manno-heptulose, perseitol, glucose, and fructose in avocado cultivars. J Agric Food Chem 1980;28:379-62. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Pharmacist Counseling Corner

Avocado Sugar Extract: Common Questions

What is Avocado Sugar Extract used for, and does it work?
People use Avocado Sugar Extract for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Avocado Sugar Extract interact with prescription medications?
Yes. We list 86 medications with a known interaction with Avocado Sugar Extract. Use the checker above to see how Avocado Sugar Extract interacts with a specific drug.
How are Avocado Sugar Extract interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Avocado Sugar Extract with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Avocado Sugar Extract interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Avocado Sugar Extract used for?
It is most commonly used in supplements aimed at blood sugar, metabolism, and weight management, mainly because it contains a rare sugar called D-mannoheptulose. However, strong human evidence for these uses is lacking.
Is Avocado Sugar Extract the same as eating an avocado?
No. The extract is a concentrated source of D-mannoheptulose, while a whole avocado provides healthy fats, fiber, and many nutrients along with only small amounts of this sugar. Eating avocado as a food is not the same as taking a supplement extract.
Is Avocado Sugar Extract safe?
Avocado as a food is generally well tolerated, but the concentrated extract has limited human safety data. People with diabetes, low blood sugar, or avocado allergy should be cautious and talk to a healthcare provider first.
Can I take it if I'm pregnant or breastfeeding?
There isn't enough safety information for use during pregnancy or breastfeeding, so it is best to avoid it during these times.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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