Drug & supplement interaction

Avocado Sugar Extract + Progesterone

Progesterone brand name: Milprosa.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Avocado Sugar Extract and Progesterone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Avocado Sugar Extract and Progesterone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Progesterone and Avocado Sugar Extract in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Avocado Sugar Extract safety at a glance

Avocado Sugar Extr... overall Not established Human safety data are very limited, so its long-term safety is not well established.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoiding it is the cautious choice.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Progesterone and Avocado Sugar Extract? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Progesterone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Progesterone is filed under 3 classifications — including topical drugs, cytochrome p450 3a4 (cyp3a4) substrates. Avocado Sugar Extract has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Progesterone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Avocado Sugar Extract Does Interact With Other Medications

Avocado Sugar Extract has 86 moderate known drug interactions in our database — Progesterone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Progesterone)
Taking anything else?

Check Another of Your Medications Against Avocado Sugar Extract

Covers the 2,830 medications we’ve checked against Avocado Sugar Extract. Pick one to open its full report.

What to actually watch for

What Progesterone’s Own FDA Label Lists

This is not an interaction — none of it involves Avocado Sugar Extract. These are the most notable effects listed in the ADVERSE REACTIONS section of Progesterone’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 2 of them are worth acting on rather than waiting out — marked below.

  • Chest pain Worth acting on
  • Low mood Worth acting on
  • Breast tenderness
  • Flushing
  • Bloating or gas
  • Sweating
  • Joint pain
  • Constipation
  • Swelling
  • Dizziness mentioned in 4.2% of FDA reports for Progesterone

Showing the 10 most notable of 15 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Progesterone. Read the label on DailyMed › Where a percentage is shown, it is the share of 22,512 voluntary FDA FAERS reports for Progesterone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Avocado Sugar Extract’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Avocado Sugar Extract side to compare — that is a limit of the record, not a statement that Avocado Sugar Extract has no side effects.

From our Q&A

Questions About Avocado Sugar Extract or Progesterone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Avocado Sugar Extract or Progesterone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Progesterone

This page covers Avocado Sugar Extract only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Progesterone page lists 126 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate), Adrafinil (moderate) and African Wild Potato (moderate).

By severity: 2 major · 91 moderate · 33 minor.

From our pharmacist’s overview on the Progesterone page

“Many people take progesterone (Milprosa) to support a pregnancy during fertility treatment or as part of hormone therapy, which is exactly when St. John's wort for mood or a morning glass of grapefruit juice can feel harmless.”

Reviewed by 2 · Jul 18, 2026

Open the Progesterone interaction page

How much people look this up

Where Avocado Sugar Extract and Progesterone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Avocado Sugar Extract
Steady interest

#978 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Progesterone
Top 25%

#565 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Avocado Sugar Extract reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Avocado Sugar Extract and Progesterone records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Avocado Sugar Extract

What is Avocado Sugar Extract?

  • Blood sugar support
  • Weight management
  • Healthy aging/longevity interest
  • Metabolic support
  • Athletic/animal supplement formulas

Avocado sugar extract is a source of D-mannoheptulose, an unusual sugar studied mainly in laboratory and animal research for its possible effects on glucose metabolism. Human evidence is very limited, so it should not be relied on to treat diabetes or any condition. Talk with your pharmacist or doctor before using it, especially if you have blood sugar concerns.

Persea americana · Lauraceae · Fruit (avocado pulp) · Capsules, powders, and standardized extracts; sometimes included in supplement blends

An interaction check asks whether these two react with each other — it does not ask whether Avocado Sugar Extract is a good idea for someone in your situation. Here is what our Avocado Sugar Extract record says about it on its own.

Avocado Sugar Extract: dosing

There is no established standardized dose for avocado sugar extract or D-mannoheptulose in humans. Products vary widely in how much extract they contain and how it is standardized.If you choose to use it, follow the directions on the product label and do not exceed them.

From our Avocado Sugar Extract monograph — the full record covers uses, side effects and every documented interaction.

Read the full Avocado Sugar Extract monograph & all interactions
Medication

About Progesterone

What Is Progesterone Used For?

Brand name: Milprosa

Progesterone capsules (including Prometrium) are used to prevent endometrial hyperplasia (abnormal thickening of the uterine lining) in postmenopausal women with a uterus who are taking estrogen, and to treat secondary amenorrhea (missed periods not caused by pregnancy).

Progesterone injection is indicated for amenorrhea and abnormal uterine bleeding caused by a hormonal imbalance. Crinone vaginal gel is used as part of Assisted Reproductive Technology (ART) for progesterone supplementation or replacement, and Crinone 4% is also indicated for secondary amenorrhea. Vaginal inserts — including Endometrin and other progesterone vaginal insert products — are used to support embryo implantation and early pregnancy as part of an ART treatment program for infertile women.

Most-Reported Side Effects for Progesterone

From FAERS, the FDA’s public side-effect reporting system (22,803 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Headache 2,094 reports
Fatigue 1,795 reports
Nausea 1,475 reports
Rash 984 reports
Dizziness 941 reports
See full Progesterone drug information
Keep checking

Other Drugs & Avocado Sugar Extract

Browse every other medication we’ve checked against Avocado Sugar Extract — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Avocado Sugar Extract page.

No interaction 2,743 drugs checked — show the list

We also checked Avocado Sugar Extract against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Avocado Sugar Extract list.

See the full Avocado Sugar Extract interactions page
See every supplement checked against Progesterone, ranked by severity
Evidence & sources

Avocado Sugar Extract References

The 1 references that drive our Avocado Sugar Extract monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Shaw PE, Wilson CW 3rd, Knight RJ Jr. High-performance liquid chromatographic analysis of D-manno-heptulose, perseitol, glucose, and fructose in avocado cultivars. J Agric Food Chem 1980;28:379-62. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Avocado Sugar Extract and Progesterone Together: Common Questions

Is it safe to take Avocado Sugar Extract with Progesterone?
We do not list a known interaction between Avocado Sugar Extract and Progesterone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Avocado Sugar Extract and Progesterone combination checked?
Interactions in our licensed database are recorded against drug classes. Progesterone is filed under 3 classifications, and Avocado Sugar Extract has documented interactions with 1 drug class — none of Progesterone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Avocado Sugar Extract interact with any other medications?
Yes. Avocado Sugar Extract has 86 documented drug interactions in our database — Progesterone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Progesterone interact with any supplements?
Yes. Progesterone has documented interactions with 126 supplements in our database — Avocado Sugar Extract is not one of them. The Progesterone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Avocado Sugar Extract monograph Uses, safety profile, and every drug interaction in one place Progesterone drug information The full plain-English guide to this medication Progesterone supplement interactions Every supplement checked against Progesterone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Progesterone and Avocado Sugar Extract?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.