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Progesterone

Progesterone is a hormone used in several forms: to support pregnancy in fertility treatment, to treat missed periods (secondary amenorrhea), to protect the uterine lining during estrogen therapy after menopause, and to treat abnormal uterine bleeding.

Brand names PrometriumEazi-Breed CIDRCrinoneEndometrinP75 Lav Progesterone Cream +3 more
Drug class Progesterone
Rx Forms 6
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 55 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

Other forms & routes:
Vaginal
Progesterone at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Progesterone is a hormone identical to the one the ovaries make, used to support pregnancy in fertility treatment, restart missed periods, control abnormal uterine bleeding and protect the uterine lining during estrogen therapy after menopause; it dates to about 1960 and is available generically. Most people handle it well, noticing drowsiness, dizziness, breast tenderness or bloating if anything. Its boxed warning covers estrogen plus progestin, which raised the risk of blood clots, stroke, heart attack, invasive breast cancer and probable dementia, so it is never a way to protect your heart or memory. Use the lowest dose for the shortest time, and recheck the need with your prescriber.

Clinical pearls

  • Prometrium and generic progesterone capsules contain peanut oil, so avoid them if you have a peanut allergy.
  • Take the capsules at bedtime so drowsiness works for you; food raised absorption in a study, so keep meals consistent.
  • If you take it with estrogen, tell your surgeon, since stopping 4 to 6 weeks before clot-prone surgery may be advised.
  • Mention it before blood work, since progesterone with estrogen can shift liver, clotting and thyroid test results.
How we write & review this content — our editorial policy →
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾

Progestins taken with estrogen should not be used to prevent heart disease, heart attacks, strokes, or dementia.

In a large study of postmenopausal women, estrogen plus progestin raised the risk of blood clots in the legs and lungs, stroke, heart attack, and invasive breast cancer. In women 65 and older, it also raised the risk of probable dementia. It is unknown whether this applies to younger postmenopausal women.

These risks are assumed to be similar for other doses and forms of estrogen and progestin. Talk regularly with your healthcare provider about whether you still need treatment.

Read the full warning on DailyMed →
How you get itPrescription only
Comes asCapsule, Injection, Topical (transdermal) gel +3
Earliest FDA record1960
Companies listing it with the FDA28
FDA label last updatedJul 23, 2026
FDA’s strongest warning (boxed)Yes, read the warning

Patient information guide A plain-language walkthrough of Progesterone, written from its FDA label.

What Progesterone is used for

▾

Progesterone is a hormone with different approved uses depending on the product.

  • Endometrin vaginal insert: supports embryo implantation and maintains pregnancy up to 10 weeks in infertile women under 35 in fertility treatment.
  • Progesterone vaginal inserts: support embryo implantation and early pregnancy in fertility treatment for infertile women.
  • Crinone vaginal gel: the 8% strength is for progesterone supplementation or replacement in fertility treatment; the 4% strength treats secondary amenorrhea.
  • Prometrium and Progesterone oral capsules: prevent endometrial hyperplasia (overgrowth of the uterine lining) in postmenopausal women with a uterus taking conjugated estrogens tablets, and treat secondary amenorrhea.
  • Progesterone injection (intramuscular): treats amenorrhea and abnormal uterine bleeding due to hormonal imbalance when there is no structural cause such as fibroids or uterine cancer.
  • P25 Progesterone Cream: described as giving temporary relief of menopausal symptoms such as hot flashes. Other listed creams are labeled for external cosmetic use.

How Progesterone works

▾

Progesterone capsules contain micronized progesterone, which is chemically identical to the progesterone made by the ovaries. Micronizing it (grinding it into very fine particles) helps your body absorb more of it.

Progesterone dosage

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The regimen depends on the product, so follow your prescriber and your label.

  • Prometrium and Progesterone capsules: taken orally once daily at bedtime for a set number of days. Take with a full glass of water while standing if swallowing is hard.
  • Endometrin and Progesterone vaginal inserts: placed in the vagina two or three times daily, starting the day after egg retrieval, for up to 10 weeks.
  • Crinone: placed in the vagina, with frequency depending on the use and strength.
  • Progesterone injection: given into a muscle over several days by a healthcare professional.
  • Creams: applied to the skin once or twice daily, as directed.

Dosing details from the FDA-approved label

From the Progesterone prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Assisted Reproductive Technology – women who require progesterone supplementation (Crinone 8%, vaginal)
    • 90 mg vaginally once daily
    • If pregnancy occurs, treatment may be continued until placental autonomy is achieved, up to 10 to 12 weeks
  • Assisted Reproductive Technology – women with partial or complete ovarian failure who require progesterone replacement (Crinone 8%, vaginal)
    • 90 mg vaginally twice daily
    • If pregnancy occurs, treatment may be continued until placental autonomy is achieved, up to 10 to 12 weeks
  • Secondary Amenorrhea (Crinone, vaginal gel)
    • Crinone 4% vaginally every other day up to a total of six doses
    • For women who fail to respond, a trial of Crinone 8% every other day up to a total of six doses may be instituted
    • A dosage increase from the 4% gel can only be accomplished by using the 8% gel; increasing the volume of gel does not increase the amount of progesterone absorbed
  • Progesterone vaginal insert / Endometrin (starting the day after oocyte retrieval)
    • 100 mg administered vaginally two or three times daily starting the day after oocyte retrieval and continuing for up to 10 weeks total duration
    • Efficacy in women 35 years of age and older has not been clearly established; the appropriate dose in this age group has not been determined
  • Prevention of Endometrial Hyperplasia (oral capsules)
    • 200 mg orally as a single daily dose at bedtime for 12 days sequentially per 28-day cycle, to a postmenopausal woman with a uterus who is receiving daily conjugated estrogens tablets
    • For difficulty swallowing, take with a glass of water while in the standing position
  • Treatment of Secondary Amenorrhea (oral capsules)
    • Single daily dose of 400 mg at bedtime for 10 days
    • For difficulty swallowing, take with a glass of water while in the standing position
  • Amenorrhea (intramuscular injection)
    • Five to 10 mg are given for six to eight consecutive days
    • Withdrawal bleeding can be expected 48 to 72 hours after the last injection if there has been sufficient ovarian activity to produce a proliferative endometrium
  • Functional Uterine Bleeding (intramuscular injection)
    • Five to 10 mg are given daily for six doses
    • When estrogen is given as well, progesterone is begun after two weeks of estrogen therapy; if menstrual flow begins during injections, they are discontinued
  • BUNUSS Phyto-Pro Skin Cream (topical)
    • Apply one pump once or twice daily
    • A pattern of 3 weeks of use with a 1-week pause is recommended (or as directed by a doctor)
  • P75 Lav / P50 / P25 Progesterone Cream (transdermal)
    • Apply once or twice a day
    • Massage into inner arms, thighs, chest or apply to inner forearm and rub arms together, or use as directed by your physician
Read the label’s full dosing text

DOSAGE AND ADMINISTRATION Prevention of Endometrial Hyperplasia Progesterone capsules should be given as a single daily dose at bedtime, 200 mg orally for 12 days sequentially per 28-day cycle, to postmenopausal women with a uterus who are receiving daily conjugated estrogens tablets. Treatment of Secondary Amenorrhea Progesterone capsules may be given as a single daily dose of 400 mg at bedtime for 10 days. Some women may experience difficulty swallowing progesterone capsules. For these women, progesterone capsules should be taken with a glass of water while in the standing position. HOW SUPPLIED Progesterone, capsules 100 mg are available as an oval yellow, opaque, capsule imprinted with P-3 in black ink. NDC 68788-8709-3 (Bottle of 30) Store at 20-25°C (68-77°F). [See USP Controlled Room Temperature] Protect from excessive moisture Keep out of reach of children. Dispense in tight, light-resistant container as defined in USP/NF, accompanied by a Patient Insert. Manufactured for: Bionpharma Inc. Princeton, NJ 08540, USA 05/2023 For India Manufacturing Site MADE IN INDIA 04/2023 204000861

Read the full Dosage and Administration section on DailyMed →

Progesterone side effects

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In a trial of progesterone capsules taken with estrogen, these were reported most often:

Common side effects

  • Headache
  • Breast tenderness
  • Joint pain
  • Depression
  • Dizziness
  • Abdominal bloating
  • Vaginal discharge
  • Nausea or vomiting

When to get medical help

  • Get emergency help for signs of a stroke or heart attack, such as sudden weakness, trouble speaking, or chest pain.
  • Get help for signs of a blood clot in the leg or lung, such as leg swelling or pain, or sudden shortness of breath.
  • Call your doctor right away if you have sudden partial or complete vision loss, bulging eyes, double vision, or a sudden migraine.
  • Tell your doctor about any lump in your breast or abnormal mammogram.
  • Report unexplained or persistent abnormal vaginal bleeding.

Progesterone warnings and precautions

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  • Estrogen plus progestin raises the risk of blood clots, stroke, heart attack, and invasive breast cancer.
  • In women 65 and older, estrogen plus progestin raised the risk of probable dementia.
  • It should not be used to prevent heart disease or dementia.
  • Stop and call your doctor right away if a stroke, clot, or sudden vision loss occurs or is suspected.
  • Get yearly breast exams and regular mammograms.
  • Persistent abnormal vaginal bleeding needs evaluation.

Progesterone interactions

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Few interactions are described in the label.

  • Ketoconazole: slowed progesterone breakdown in lab testing.
  • Lab tests: estrogen plus progestin can change liver, clotting, and thyroid results, so tell any lab or doctor you take it.

Interactions listed in the FDA-approved label

From the Progesterone prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Hepatic function tests (sulfobromophthalein retention and others): Estrogen plus progestin therapy may increase sulfobromophthalein retention and other hepatic function test results.
  • Coagulation tests: Estrogen plus progestin therapy may increase prothrombin factors VII, VIII, IX and X.
  • Pregnanediol determination: Estrogen plus progestin therapy may alter pregnanediol determination results.
  • Thyroid function tests: Estrogen plus progestin therapy may increase PBI and butanol extractable protein bound iodine and decrease T3 uptake values.
Read the label’s full interactions text

C. Drug–Laboratory Test Interactions The following laboratory results may be altered by the use of estrogen plus progestin therapy: Increased sulfobromophthalein retention and other hepatic function tests. Coagulation tests: increase in prothrombin factors VII, VIII, IX and X. Pregnanediol determination. Thyroid function: increase in PBI, and butanol extractable protein bound iodine and decrease in T3 uptake values.

Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

🌿126 supplements and herbs with documented Progesterone interactions, ranked by severity Check Progesterone against a supplement or herb →

Before taking Progesterone

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  • Peanut allergy: progesterone capsules contain peanut oil and must not be used.
  • Do not use capsules with undiagnosed abnormal vaginal bleeding.
  • Do not use capsules with a history of breast cancer, blood clots, stroke, or heart attack.
  • Do not use capsules with known liver disease.
  • Do not use capsules if pregnant or suspected pregnant.
  • Endometrin has not been clearly shown to work in women 35 and older.
  • Tell your doctor about high blood pressure, diabetes, smoking, high cholesterol, or obesity.

Progesterone overdose

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No overdose studies have been done in humans. For Prometrium capsules, the label says to stop the medicine and treat symptoms.

How your body processes Progesterone

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After swallowing progesterone capsules, blood levels peak within about 3 hours. Eating food increased how much was absorbed. The liver breaks progesterone down, and the waste products leave mainly through the kidneys and bile. The effects of liver or kidney problems have not been studied.

How to store Progesterone

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Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F) . Protect from excessive moisture. Dispense in tight, light-resistant container as defined in USP/NF, accompanied by a Patient Insert.

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

126

Supplements & herbs that interact with Progesterone

126 supplements and herbal products have documented interactions with Progesterone in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 2
  • Moderate · 91
  • Minor · 33
GRAPEFRUIT Major ST. JOHN'S WORT Major ACACIA RIGIDULA Moderate ADRAFINIL Moderate AFRICAN WILD POTATO Moderate AMERICAN ELDER Moderate ASTAXANTHIN Moderate AYAHUASCA Moderate +118 more
Every supplement checked against Progesterone — ranked by severity The full interaction hub: 2 major · 91 moderate · 33 minor · every one linked to its full report. Check Progesterone against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

Progesterone: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Progesterone — the kind of thing our pharmacy team would talk through with you at the counter.

What is progesterone used for?

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It depends on the product. Vaginal forms support pregnancy in fertility treatment. Capsules prevent overgrowth of the uterine lining in postmenopausal women taking estrogen, and treat missed periods. The injection treats missed periods and abnormal uterine bleeding.

How should I take the capsules?

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Take them at bedtime, as your prescriber directs. If they're hard to swallow, use a full glass of water while standing. Food can increase how much your body absorbs.

What side effects should I expect?

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With capsules taken alongside estrogen, headache, breast tenderness, joint pain, dizziness, and bloating were common. Vaginal discharge and nausea were reported too. Tell your doctor if these bother you.

When should I call my doctor right away?

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Get help for chest pain, sudden weakness or trouble speaking, leg swelling, or sudden shortness of breath. These can be signs of a stroke, heart attack, or blood clot. Sudden vision loss or double vision also needs prompt attention.

Who shouldn't take progesterone capsules?

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Don't take them if you are allergic to peanuts, since they contain peanut oil. They also aren't for people with breast cancer, past blood clots, stroke, or heart attack, liver disease, undiagnosed vaginal bleeding, or known or suspected pregnancy.

Can progesterone with estrogen protect my heart or memory?

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No. It should not be used to prevent heart disease, heart attacks, strokes, or dementia. Studies showed higher risks of those problems, so keep reviewing with your prescriber whether you still need it.

Is Progesterone available over the counter?

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No. Progesterone is a prescription medicine: every Progesterone product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Progesterone first available?

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The earliest FDA record we hold for Progesterone is from 1960: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Progesterone was first used.

Who makes Progesterone?

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28 companies currently list Progesterone products in the FDA's NDC Directory, including Asclemed USA, Inc., Bryant Ranch Prepack, Proficient Rx LP. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Progesterone on HelloPharmacist

📊Progesterone supplement interactions126 checked — ranked by severity 🌿Drug & Supplement CheckerProgesterone vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Progesterone NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
Detailed data & references for Progesterone Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Progesterone forms and strengths (how it comes)

Progesterone is available in 6 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Capsule

By mouth
Brands Prometrium
How this form is used
What it may be used for
  • Prometrium and Progesterone capsules prevent endometrial hyperplasia in postmenopausal women with a uterus who take conjugated estrogens tablets.
  • Prometrium and Progesterone capsules treat secondary amenorrhea.
Important instructions
  • Prometrium and Progesterone capsules are taken once daily at bedtime.
  • If swallowing is hard, Prometrium and Progesterone capsules should be taken with a glass of water while standing.
Available strengths 3 strengths
100 mg 200 mg 400 mg
140 FDA-listed product records ⓘ

Injection

Into a muscle
How this form is used
What it may be used for
  • Progesterone injection treats amenorrhea and abnormal uterine bleeding due to hormonal imbalance when there is no underlying structural cause such as fibroids or uterine cancer.
Important instructions
  • Progesterone injection is given into a muscle and can be irritating at the injection site.
  • Progesterone injection is given daily over several days, depending on the condition.
Available strengths 2 strengths
50 mg 50 mg/mL
9 FDA-listed product records ⓘ

Topical (transdermal) gel

Through the skin
Brands P75 Lav Progesterone Cream
How this form is used
What it may be used for
  • P25 Progesterone Cream is described as giving temporary relief from menopausal symptoms such as hot flashes.
Important instructions
  • P25, P50 and P75 Lav Progesterone Creams are applied once or twice a day, or as directed by your physician.
  • P25, P50 and P75 Lav Progesterone Creams are massaged into the inner arms, thighs, or chest.
Available strengths 2 strengths
1 mg/mg 25 mg/85 g
6 FDA-listed product records ⓘ

Vaginal cream or gel

Vaginal
Brands Crinone
How this form is used
What it may be used for
  • Crinone 8% provides progesterone supplementation or replacement in fertility treatment for women with progesterone deficiency.
  • Crinone 4% treats secondary amenorrhea, and Crinone 8% is used if a woman does not respond to Crinone 4%.
Important instructions
  • Crinone is given vaginally. For fertility treatment, Crinone 8% is used once or twice daily.
  • For secondary amenorrhea, Crinone is given every other day for up to six doses.
  • Using more Crinone gel does not increase the amount of progesterone absorbed.
Available strengths 2 strengths
45 mg/1.125 g 90 mg/1.125 g
6 FDA-listed product records ⓘ

Vaginal insert

Vaginal
Brands Endometrin Progesterone vaginal insert Progesterone Vaginal Inserts
How this form is used
What it may be used for
  • Endometrin supports embryo implantation and helps maintain pregnancy up to 10 weeks in infertile women under 35 in fertility treatment.
  • Progesterone vaginal inserts support embryo implantation and early pregnancy in fertility treatment for infertile women.
Important instructions
  • Endometrin and Progesterone vaginal inserts are placed in the vagina two or three times daily.
  • Endometrin and Progesterone vaginal inserts start the day after egg retrieval and continue for up to 10 weeks.
  • For Endometrin and Progesterone vaginal inserts, effectiveness in women 35 and older has not been clearly established.
Available strengths 1 strength
100 mg
6 FDA-listed product records ⓘ

Topical cream, ointment or gel

On the skin
Brands BUNUSS Phyto-Pro Skin Cream
How this form is used
Important instructions
  • BUNUSS Phyto-Pro Skin Cream is applied as one pump once or twice daily to clean, dry skin and massaged until absorbed.
  • BUNUSS Phyto-Pro Skin Cream is used in a pattern of 3 weeks on and 1 week off, or as a doctor directs.
  • With BUNUSS Phyto-Pro Skin Cream, wash your hands after use and avoid direct sunlight on the area.
Available strengths 1 strength
16.9 mg/mL
1 FDA-listed product record ⓘ

Progesterone on the U.S. market: products, makers and brands

How Progesterone appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

28 companies list 83 Progesterone product records with the FDA, mostly as capsule, injection, topical (transdermal) gel; the earliest marketing or approval year on record is 1960. Brand names on the directory include Prometrium, Eazi-Breed CIDR, Crinone and 5 more; the rest are generics.

6
Dose forms ⓘ
28
Labelers (makers, repackagers, distributors)
10
Brand names
83
FDA-listed product records ⓘ
1960
Earliest FDA record ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (71) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Asclemed USA, Inc.12%
Bryant Ranch Prepack8%
Proficient Rx LP6%
A-S Medication Solutions5%
AvKARE5%
Bionpharma Inc.5%
Other makers59%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Progesterone is used (Medicaid data)

A general measure of how commonly Progesterone is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Progesterone is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

725,527
Medicaid prescriptions filled (Q1–Q4 2025)
$16.9M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Progesterone prescribed? Of the 1,601 medications we measure, Progesterone ranks #214 by Medicaid prescriptions — more than 87% of them.

Where Progesterone ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #214 of 1,601
#209 Rizatriptan 745,530 Rx #210 Tiotropium Oral Inhala... 739,246 Rx #211 Lacosamide 735,538 Rx #212 Acyclovir 733,721 Rx #213 Testosterone 731,644 Rx #214 Progesterone 725,527 Rx #215 Sucralfate 724,768 Rx #216 Ketotifen Ophthalmic 714,559 Rx #217 Ketotifen 714,559 Rx #218 Metoclopramide 712,920 Rx #219 Ofloxacin Otic 706,749 Rx

Utilization by Progesterone product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 100 mg oral capsule is the most-dispensed Progesterone product — about 58% of these Medicaid prescriptions.

progesterone 100 MG Oral Capsule Most dispensed

421,068 Medicaid prescriptions (Q1–Q4 2025) 58% of Progesterone prescriptions shown $8.4M gross reimbursement (before rebates) ≈ $20 per prescription (gross)

Summed across the 7 of 100 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 260243

progesterone 200 MG Oral Capsule

299,869 Medicaid prescriptions (Q1–Q4 2025) 41% of Progesterone prescriptions shown $7.5M gross reimbursement (before rebates) ≈ $25 per prescription (gross)

Summed across the 5 of 113 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 312641

progesterone 50 MG/ML Injectable Solution

2,906 Medicaid prescriptions (Q1–Q4 2025) <1% of Progesterone prescriptions shown $100,918 gross reimbursement (before rebates) ≈ $35 per prescription (gross)

Summed across the 5 of 6 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 312644

progesterone 100 MG Vaginal Insert

1,177 Medicaid prescriptions (Q1–Q4 2025) <1% of Progesterone prescriptions shown $701,767 gross reimbursement (before rebates) ≈ $596 per prescription (gross)

Summed across the 2 of 14 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 725094

progesterone 0.08 MG/MG Vaginal Gel

474 Medicaid prescriptions (Q1–Q4 2025) <1% of Progesterone prescriptions shown $238,959 gross reimbursement (before rebates) ≈ $504 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 312645

progesterone 0.04 MG/MG Vaginal Gel

33 Medicaid prescriptions (Q1–Q4 2025) <1% of Progesterone prescriptions shown $3,856 gross reimbursement (before rebates) ≈ $117 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 312643

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Progesterone, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 21 of 237 listed Progesterone NDCs with Medicaid activity.

Compare Progesterone products

A representative set of FDA-listed product records for Progesterone — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 83 of 83 products — FDA National Drug Code Directory. See every product, package size and price: browse all 83 Progesterone NDCs →

Progesterone recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list 2 Progesterone recalls since July 2021. Both are still ongoing or began in the last six months. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.

Ongoing Class II Dec 27, 2024 · Eugia US LLC
Presence of Particulate Matter: A market complaint was received of a glass piece in the vial.
  • Progesterone Injection USP, 500mg per 10 mL (50mg/mL), 10 mL Multiple Dose Vial, Rx Only, Mfd. in India for: Eugia US LLC. E. Windsor NJ 08520 NDC # 55150-306-10 Lots: Batch # 1PR24010, Expiry: 02/28/2027 FDA record D-0186-2025 →
Ongoing Class II Jul 26, 2024 · Eugia US LLC
Presence of Particulate Matter: Complaint received of a glass particle in the vial.
  • Progesterone Injection, USP, 500 mg per 10 mL (50mg/mL), 10 mL Multiple-Dose Vial, Rx Only, Mfd. in India for: Eugia US LLC, E Windsor, NJ 08520, NDC 55150-306-10. Lots: Lot #: CPR230029A FDA record D-0624-2024 →

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Progesterone RxCUI 8727 5 dose forms · 9 strengths
  1. Dose form (SCDF) Injectable Solution RxCUI 374412 In current FDA listings
    Clinical drug / strength (SCD) 50 MG/ML RxCUI 312644
  2. Dose form (SCDF) Oral Capsule RxCUI 373616 In current FDA listings
    Clinical drug / strength (SCD) 100 MG RxCUI 260243 200 MG RxCUI 312641
  3. Dose form (SCDF) Topical Oil RxCUI 2716917 In current FDA listings
    Clinical drug / strength (SCD) 213 MG/ML RxCUI 2716918
  4. Dose form (SCDF) Vaginal Gel RxCUI 377270 In current FDA listings
    Clinical drug / strength (SCD) 0.04 MG/MG RxCUI 312643 0.08 MG/MG RxCUI 312645
  5. Dose form (SCDF) Vaginal Insert RxCUI 2109022 In current FDA listings
    Clinical drug / strength (SCD) 100 MG RxCUI 725094 300 MG RxCUI 1251720 1380 MG RxCUI 1372907

Look up RxCUI 8727 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

💵 What Progesterone costs pharmacies (NADAC benchmark)

The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.

FormStrengthPharmacy acquisition benchmark
Capsule · Oral 100 mg $0.229 per capsule NDC details & price history
Capsule · Oral 200 mg $0.404 per capsule NDC details & price history
Injection, Solution · Intramuscular 50 mg/mL $1.36 per mL NDC details & price history
Insert · Vaginal 100 mg $15.15 each NDC details & price history
Gel · Vaginal 45 mg/1.125 g $16.84 per gram NDC details & price history
Gel · Vaginal 90 mg/1.125 g $27.97 per gram NDC details & price history
Why show this? Your out-of-pocket cost depends on insurance, pharmacy markup, and discounts — but the acquisition benchmark tells you whether the medication itself is inexpensive or costly, which strengths cost more per dose, and whether a cash-price quote is in a reasonable range. Each row links to the NDC-level record with its full price history.

Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.

Progesterone brand names

Progesterone is sold under 8 brand names in the FDA directory — Prometrium, Eazi-Breed CIDR, Crinone, Endometrin and others. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Prometrium Eazi-Breed CIDR Crinone Endometrin P75 Lav Progesterone Cream Progesterone Vaginal Inserts Progesterone vaginal insert BUNUSS Phyto-Pro Skin Cream

Who makes Progesterone: manufacturers and labelers

28 companies list Progesterone products with the FDA. By number of product records, the largest are Asclemed USA, Inc., Bryant Ranch Prepack, Proficient Rx LP. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Asclemed USA, Inc. 10 Bryant Ranch Prepack 7 Proficient Rx LP 5 A-S Medication Solutions 4 AvKARE 4 Bionpharma Inc. 4 NorthStar Rx LLC 4 NuCare Pharmaceuticals,Inc. 4 Preferred Pharmaceuticals Inc. 4 Xiromed, Llc 4 direct rx 4 Hikma Pharmaceuticals USA Inc 3 Remedyrepack Inc. 3 Shyne Brands 3 Acertis Pharmaceuticals, LLC 2 Allergan, Inc. 2 Amneal Pharmaceuticals LLC 2 Aurobindo Pharma Limited 2 Dr. Reddys Laboratories, Inc. 2 Golden State Medical Supply, Inc. 2 Eugia US LLC 1 Ferring Pharmaceuticals Inc. 1 Fresenius Kabi USA, LLC 1 Glenmark Pharmaceuticals Inc., USA 1

…and 4 more on the FDA NDC directory.

Progesterone drug class (RxNorm)

Progesterone belongs to the Progesterone class.

Pharmacologic class Progesterone
Drug family (ATC) Pregnen (4) derivatives

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Progesterone page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Jul 23, 2026
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Progesterone.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Progesterone after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
55
Finished products in the current FDA directory
83
Companies listing them (makers, repackagers, distributors)
28
FDA labeler codes behind them ⓘ
32
Linked representative label ⓘ
Acertis Pharmaceuticals, LLC
Linked label effective
Jul 23, 2026
Composite sections available
20
Linked SPL Set ID
1cf237ff-c4f8-4faa-a7aa-77599c856889
Linked SPL Document ID
4ff93bfe-305d-4956-bec9-5ac1d469b34f
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Acertis Pharmaceuticals, LLC is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →