Lacosamide

Generic name: Pronounced as (la koe' sa mide)
Brand names
  • Vimpat®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 01/15/2022

Lacosamide is used to control partial onset seizures (seizures that involve only one part of the brain) in adults and children 1 month of age and older. Lacosamide is also used in combination with other medications to control primary generalized tonic-clonic seizures (formerly known as a grand mal seizure; seizure that involves the entire body) in adults and children 4 years of age and older. Lacosamide is in a class of medications called anticonvulsants. It works by decreasing abnormal electrical activity in the brain.

Lacosamide comes as a tablet and as an solution (liquid) to take by mouth. It is usually taken twice a day with or without food. Take lacosamide at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take lacosamide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablets whole; do not chew, split. or crush them.

If you are taking the oral solution, use a dose measuring spoon or oral syringe to measure the correct amount of liquid needed for each dose. Do not use a regular household spoon. If you have a nasogastric (NG) or gastric tube, your doctor or pharmacist will explain how to prepare lacosamide to administer it.

Your doctor will probably start you on a low dose of lacosamide and gradually increase your dose, not more often than once a week.

Lacosamide may help control your condition but will not cure it. It may take a few weeks or longer before you feel the full benefit of lacosamide. Continue to take lacosamide even if you feel well. Do not stop taking lacosamide without talking to your doctor, even if you experience side effects such as unusual changes in behavior or mood. If you suddenly stop taking lacosamide, your seizures may happen more often. Your doctor will probably decrease your dose gradually.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking lacosamide,

  • tell your doctor and pharmacist if you are allergic to lacosamide, any other medications, or any of the ingredients in lacosamide tablets or oral solution. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: beta blockers such as atenolol (Tenormin, in Tenoretic), labetalol (Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Hemangeol, Inderal); calcium channel blockers such as amlodipine (Norvasc, in Caduet, in Lotrel, in Exforge, others), diltiazem (Cardizem, Cartia, Tiazac, others), felodipine, isradipine, nicardipine, nifedipine (Procardia), nimodipine (Nymalize), nisoldipine (Sular), and verapamil (Calan, Verelan, in Tarka); and medications for irregular heartbeat such as amiodarone (Nexterone, Pacerone), digoxin (Lanoxin), dronedarone (Multaq), flecainide (Tambocor), propafenone (Rythmol), quinidine (in Nuedexta), and sotalol (Betapace, Sorine, Sotylize). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with lacosamide, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor if you currently or have ever drunk large amounts of alcohol, used street drugs, or over-used prescription medications. Also tell your doctor if you have or have ever had depression, mood problems, suicidal thoughts or behavior; an irregular heartbeat, a heart attack, a pacemaker, heart failure, or other heart problems; diabetic neuropathy (nerve damage caused by diabetes); or liver or kidney disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking lacosamide, call your doctor.

  • you should know that lacosamide may make you dizzy or drowsy and may cause blurred vision or problems with coordination and balance. Do not drive a car, operate machinery, or participate in activities requiring alertness or coordination until you know how this medication affects you.

  • you should know that your mental health may change in unexpected ways and you may become suicidal (thinking about harming or killing yourself or planning or trying to do so) while you are taking lacosamide. A small number of adults and children 5 years of age and older (about 1 in 500 people) who took anticonvulsants like lacosamide to treat various conditions during clinical studies became suicidal during their treatment. Some of these people developed suicidal thoughts and behavior as early as 1 week after they started taking the medication. There is a risk that you may experience changes in your mental health if you take an anticonvulsant medication such as lacosamide, but there may also be a risk that you will experience changes in your mental health if your condition is not treated. You and your doctor will decide whether the risks of taking an anticonvulsant medication are greater than the risks of not taking the medication. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: panic attacks; agitation or restlessness; new or worsening irritability, anxiety, or depression; acting on dangerous impulses; difficulty falling asleep or staying asleep; aggressive, angry, or violent behavior; mania (frenzied, abnormally excited mood); talking or thinking about wanting to hurt yourself or end your life; or any other unusual changes in behavior or mood. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.

  • you should know that lacosamide may cause dizziness, lightheadedness, fainting, or irregular heartbeat, especially when you get up too quickly from a lying position. If you develop these symptoms, lie down with your legs raised until you feel better, and call your doctor right away.

  • if you have phenylketonuria (PKU, an inherited condition in which a special diet must be followed to prevent damage to your brain that can cause severe intellectual disability), you should know that lacosamide oral solution contains aspartame that forms phenylalanine.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Lacosamide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • vomiting

    • diarrhea

    • blurred or double vision

    • uncontrollable eye movements

    • dizziness

    • headache

    • drowsiness

    • uncontrollable shaking of a part of the body

    • problems with coordination, balance, or walking

    • weakness

    • itching

  • Some side effects can be serious. If you experience any of these symptoms, or those listed in the SPECIAL PRECAUTIONS section, call your doctor immediately:

    • fast or pounding heartbeat or pulse

    • shortness of breath

    • slow heartbeat

    • chest pain

    • fainting

    • swelling of the face, throat, tongue, lips, and eyes

    • fever

    • rash

    • tiredness

    • yellowing of the skin or eyes

    • dark urine

  • Lacosamide may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Do not freeze the oral solution. Discard any unused oral solution 6 months after first opening the bottle.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor.

Do not let anyone else take your medication. Lacosamide is a controlled substance. Prescriptions may be refilled only a limited number of times; ask your pharmacist if you have any questions.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Montelukast Montelukast The metabolism of Lacosamide can be decreased when combined with Montelukast.
Leflunomide Leflunomide The metabolism of Lacosamide can be decreased when combined with Leflunomide.
Delavirdine Delavirdine The serum concentration of Lacosamide can be increased when it is combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Lacosamide can be decreased when combined with Nevirapine.
Dolasetron Dolasetron The risk or severity of adverse effects can be increased when Dolasetron is combined with Lacosamide.
Aminophylline Aminophylline The metabolism of Aminophylline can be decreased when combined with Lacosamide.
Candesartan Candesartan The metabolism of Lacosamide can be decreased when combined with Candesartan.
Clopidogrel Clopidogrel The metabolism of Lacosamide can be decreased when combined with Clopidogrel.
Diphenoxylate Diphenoxylate The risk or severity of adverse effects can be increased when Diphenoxylate is combined with Lacosamide.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Lacosamide can be decreased when combined with Erythromycin.
Fenofibrate Fenofibrate The metabolism of Lacosamide can be decreased when combined with Fenofibrate.
Guanfacine Guanfacine The risk or severity of adverse effects can be increased when Guanfacine is combined with Lacosamide.
Methylergonovine Methylergonovine The metabolism of Lacosamide can be decreased when combined with Methylergometrine.
Naratriptan Naratriptan The risk or severity of adverse effects can be increased when Naratriptan is combined with Lacosamide.
Paregoric Paregoric The risk or severity of adverse effects can be increased when Morphine is combined with Lacosamide.
Penbutolol Penbutolol Acebutolol may increase the bradycardic activities of Lacosamide.
Pentazocine Pentazocine The risk or severity of adverse effects can be increased when Pentazocine is combined with Lacosamide.
Reserpine Reserpine The risk or severity of adverse effects can be increased when Reserpine is combined with Lacosamide.
Rizatriptan Rizatriptan The risk or severity of adverse effects can be increased when Rizatriptan is combined with Lacosamide.
Sumatriptan Sumatriptan The risk or severity of adverse effects can be increased when Sumatriptan is combined with Lacosamide.
Tacrolimus Tacrolimus The metabolism of Tacrolimus can be decreased when combined with Lacosamide.
Tizanidine Tizanidine The risk or severity of adverse effects can be increased when Tizanidine is combined with Lacosamide.
Triamcinolone Triamcinolone The metabolism of Lacosamide can be increased when combined with Triamcinolone.
Zolmitriptan Zolmitriptan The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Lacosamide.
Doxycycline Injection Doxycycline Injection The metabolism of Lacosamide can be decreased when combined with Doxycycline.
Fluconazole Injection Fluconazole Injection The metabolism of Lacosamide can be decreased when combined with Fluconazole.
Hydromorphone Injection Hydromorphone Injection The risk or severity of adverse effects can be increased when Hydromorphone is combined with Lacosamide.
Meperidine Injection Meperidine Injection The risk or severity of adverse effects can be increased when Meperidine is combined with Lacosamide.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Lacosamide can be increased when combined with Methylprednisolone.
Metoclopramide Injection Metoclopramide Injection The risk or severity of sedation can be increased when Metoclopramide is combined with Lacosamide.
Metronidazole Injection Metronidazole Injection The metabolism of Lacosamide can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The risk or severity of adverse effects can be increased when Morphine is combined with Lacosamide.
Zidovudine Injection Zidovudine Injection The metabolism of Lacosamide can be decreased when combined with Zidovudine.
Altretamine Altretamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Lacosamide.
Cyclosporine Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Lacosamide.
Ondansetron Ondansetron The risk or severity of adverse effects can be increased when Ondansetron is combined with Lacosamide.
Granisetron Granisetron The risk or severity of adverse effects can be increased when Granisetron is combined with Lacosamide.
Torsemide Torsemide The metabolism of Lacosamide can be decreased when combined with Torasemide.
Olanzapine Olanzapine The risk or severity of adverse effects can be increased when Olanzapine is combined with Lacosamide.
Alosetron Alosetron The risk or severity of adverse effects can be increased when Alosetron is combined with Lacosamide.
Dofetilide Dofetilide The metabolism of Dofetilide can be decreased when combined with Lacosamide.
Entacapone Entacapone The risk or severity of adverse effects can be increased when Entacapone is combined with Lacosamide.
Hydroxychloroquine Hydroxychloroquine The therapeutic efficacy of Lacosamide can be decreased when used in combination with Hydroxychloroquine.
Meloxicam Meloxicam The metabolism of Lacosamide can be decreased when combined with Meloxicam.
Orlistat Orlistat Orlistat can cause a decrease in the absorption of Lacosamide resulting in a reduced serum concentration and potentially a decrease in efficacy.
Oxcarbazepine Oxcarbazepine The metabolism of Lacosamide can be decreased when combined with Oxcarbazepine.
Pantoprazole Pantoprazole The metabolism of Lacosamide can be decreased when combined with Pantoprazole.
Telmisartan Telmisartan The metabolism of Lacosamide can be decreased when combined with Telmisartan.
Zaleplon Zaleplon The risk or severity of adverse effects can be increased when Zaleplon is combined with Lacosamide.
Anakinra Anakinra The metabolism of Lacosamide can be increased when combined with Anakinra.
Desloratadine Desloratadine The risk or severity of adverse effects can be increased when Desloratadine is combined with Lacosamide.
Linezolid Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Lacosamide.
Rivastigmine Rivastigmine Rivastigmine may increase the bradycardic activities of Lacosamide.
Trimipramine Trimipramine The metabolism of Lacosamide can be decreased when combined with Trimipramine.
Etanercept Injection Etanercept Injection The metabolism of Lacosamide can be increased when combined with Etanercept.
Glycopyrrolate Glycopyrrolate Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
Modafinil Modafinil The metabolism of Lacosamide can be decreased when combined with Modafinil.
Tenofovir Tenofovir The metabolism of Tenofovir can be decreased when combined with Lacosamide.
Sirolimus Sirolimus The metabolism of Sirolimus can be decreased when combined with Lacosamide.
Epinephrine Injection Epinephrine Injection The metabolism of Lacosamide can be decreased when combined with Epinephrine.
Escitalopram Escitalopram The risk or severity of adverse effects can be increased when Lacosamide is combined with Escitalopram.
Zonisamide Zonisamide The risk or severity of adverse effects can be increased when Zonisamide is combined with Lacosamide.
Adalimumab Injection Adalimumab Injection The metabolism of Lacosamide can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The risk or severity of adverse effects can be increased when Aripiprazole is combined with Lacosamide.
Atomoxetine Atomoxetine The risk or severity of adverse effects can be increased when Atomoxetine is combined with Lacosamide.
Dexmethylphenidate Dexmethylphenidate The risk or severity of adverse effects can be increased when Lacosamide is combined with Dexmethylphenidate.
Atazanavir Atazanavir The metabolism of Lacosamide can be decreased when combined with Atazanavir.
Almotriptan Almotriptan The risk or severity of adverse effects can be increased when Almotriptan is combined with Lacosamide.
Eletriptan Eletriptan The risk or severity of adverse effects can be increased when Eletriptan is combined with Lacosamide.
Mefloquine Mefloquine The therapeutic efficacy of Lacosamide can be decreased when used in combination with Mefloquine.
Rosuvastatin Rosuvastatin The metabolism of Lacosamide can be decreased when combined with Rosuvastatin.
Aprepitant Aprepitant The metabolism of Lacosamide can be decreased when combined with Aprepitant.
Memantine Memantine The metabolism of Lacosamide can be decreased when combined with Memantine.
Frovatriptan Frovatriptan The risk or severity of adverse effects can be increased when Frovatriptan is combined with Lacosamide.
Progesterone Progesterone The metabolism of Lacosamide can be increased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The risk or severity of adverse effects can be increased when Apomorphine is combined with Lacosamide.
Infliximab Injection Infliximab Injection The metabolism of Lacosamide can be increased when combined with Infliximab.
Oxandrolone Oxandrolone The metabolism of Lacosamide can be decreased when combined with Oxandrolone.
Protriptyline Protriptyline The risk or severity of adverse effects can be increased when Protriptyline is combined with Lacosamide.
Rifaximin Rifaximin The metabolism of Lacosamide can be increased when combined with Rifaximin.
Duloxetine Duloxetine The risk or severity of adverse effects can be increased when Lacosamide is combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Lacosamide can be increased when combined with Norethisterone.
Trospium Trospium Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Bosentan Bosentan The metabolism of Lacosamide can be increased when combined with Bosentan.
Erlotinib Erlotinib The metabolism of Lacosamide can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone The risk or severity of CNS depression can be increased when Lacosamide is combined with Eszopiclone.
Ganciclovir Ganciclovir The therapeutic efficacy of Lacosamide can be decreased when used in combination with Ganciclovir.
Solifenacin Solifenacin Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Solifenacin.
Valganciclovir Valganciclovir The therapeutic efficacy of Lacosamide can be decreased when used in combination with Valganciclovir.
Voriconazole Voriconazole The metabolism of Lacosamide can be decreased when combined with Voriconazole.
Dextroamphetamine Dextroamphetamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Lacosamide.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The metabolism of Lacosamide can be increased when combined with Peginterferon alfa-2b.
Sodium Oxybate Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Lacosamide.
Isocarboxazid Isocarboxazid The risk or severity of adverse effects can be increased when Isocarboxazid is combined with Lacosamide.
Ramelteon Ramelteon The risk or severity of adverse effects can be increased when Ramelteon is combined with Lacosamide.
Darifenacin Darifenacin Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Darifenacin.
Fentanyl Fentanyl The risk or severity of adverse effects can be increased when Fentanyl is combined with Lacosamide.
Pregabalin Pregabalin The therapeutic efficacy of Lacosamide can be increased when used in combination with Pregabalin.
Deferasirox Deferasirox The metabolism of Lacosamide can be increased when combined with Deferasirox.
Tipranavir Tipranavir The metabolism of Tipranavir can be decreased when combined with Lacosamide.
Felbamate Felbamate The metabolism of Lacosamide can be decreased when combined with Felbamate.
Ranolazine Ranolazine The metabolism of Lacosamide can be decreased when combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Lacosamide can be increased when combined with Abatacept.
Rasagiline Rasagiline The risk or severity of adverse effects can be increased when Rasagiline is combined with Lacosamide.
Imatinib Imatinib The metabolism of Lacosamide can be decreased when combined with Imatinib.
Gefitinib Gefitinib The metabolism of Lacosamide can be decreased when combined with Gefitinib.
Paliperidone Paliperidone The risk or severity of adverse effects can be increased when Paliperidone is combined with Lacosamide.
Bortezomib Bortezomib The metabolism of Lacosamide can be decreased when combined with Bortezomib.
Posaconazole Posaconazole The metabolism of Lacosamide can be decreased when combined with Posaconazole.
Primaquine Primaquine The metabolism of Lacosamide can be decreased when combined with Primaquine.
Darunavir Darunavir The metabolism of Darunavir can be decreased when combined with Lacosamide.
Dimenhydrinate Dimenhydrinate The risk or severity of adverse effects can be increased when Dimenhydrinate is combined with Lacosamide.
Nabilone Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Lacosamide.
Sorafenib Sorafenib The metabolism of Lacosamide can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Lacosamide can be decreased when combined with Sunitinib.
Dronabinol Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Lacosamide.
Lapatinib Lapatinib The metabolism of Lacosamide can be decreased when combined with Lapatinib.
Levocetirizine Levocetirizine The risk or severity of adverse effects can be increased when Lacosamide is combined with Levocetirizine.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Lacosamide.
Armodafinil Armodafinil The metabolism of Lacosamide can be decreased when combined with Armodafinil.
Ivermectin Ivermectin The metabolism of Lacosamide can be increased when combined with Ivermectin.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Lacosamide.
Nilotinib Nilotinib The metabolism of Lacosamide can be decreased when combined with Nilotinib.
Bexarotene Bexarotene The metabolism of Lacosamide can be increased when combined with Bexarotene.
Budesonide Budesonide The metabolism of Lacosamide can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Lacosamide can be decreased when combined with Chloramphenicol.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Lacosamide.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Botulinum Toxin Type B is combined with Lacosamide.
Etravirine Etravirine The metabolism of Lacosamide can be decreased when combined with Etravirine.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Lacosamide can be decreased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The risk or severity of adverse effects can be increased when Lacosamide is combined with Desvenlafaxine.
Nebivolol Nebivolol The metabolism of Lacosamide can be decreased when combined with Nebivolol.
Tretinoin Tretinoin The metabolism of Lacosamide can be decreased when combined with Tretinoin.
Pilocarpine Pilocarpine The metabolism of Lacosamide can be decreased when combined with Pilocarpine.
Flecainide Flecainide The metabolism of Lacosamide can be decreased when combined with Flecainide.
Certolizumab Injection Certolizumab Injection The metabolism of Lacosamide can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Lacosamide.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Lacosamide.
Praziquantel Praziquantel The metabolism of Lacosamide can be decreased when combined with Praziquantel.
Mitotane Mitotane The metabolism of Lacosamide can be increased when combined with Mitotane.
Rufinamide Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Lacosamide.
Midazolam Midazolam The risk or severity of adverse effects can be increased when Midazolam is combined with Lacosamide.
Milnacipran Milnacipran The risk or severity of adverse effects can be increased when Lacosamide is combined with Milnacipran.
Dexlansoprazole Dexlansoprazole The metabolism of Lacosamide can be decreased when combined with Dexlansoprazole.
Sodium Phosphate Sodium Phosphate The therapeutic efficacy of Lacosamide can be decreased when used in combination with Sodium phosphate, monobasic.
Fesoterodine Fesoterodine Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine.
Betaxolol Betaxolol Betaxolol may increase the bradycardic activities of Lacosamide.
Iloperidone Iloperidone The risk or severity of adverse effects can be increased when Iloperidone is combined with Lacosamide.
Prasugrel Prasugrel The metabolism of Lacosamide can be decreased when combined with Prasugrel.
Everolimus Everolimus The metabolism of Everolimus can be decreased when combined with Lacosamide.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Tolvaptan can be decreased when combined with Lacosamide.
Dronedarone Dronedarone The metabolism of Dronedarone can be decreased when combined with Lacosamide.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Lacosamide.
Palonosetron Injection Palonosetron Injection The risk or severity of adverse effects can be increased when Palonosetron is combined with Lacosamide.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Lacosamide.
Tapentadol Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Lacosamide.
Topotecan Topotecan Topotecan may increase the excretion rate of Lacosamide which could result in a lower serum level and potentially a reduction in efficacy.
Golimumab Injection Golimumab Injection The metabolism of Lacosamide can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Pazopanib can be decreased when combined with Lacosamide.
Asenapine Asenapine The risk or severity of adverse effects can be increased when Asenapine is combined with Lacosamide.
Vigabatrin Vigabatrin The risk or severity of adverse effects can be increased when Vigabatrin is combined with Lacosamide.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Lacosamide.
Albendazole Albendazole The metabolism of Lacosamide can be decreased when combined with Albendazole.
Ulipristal Ulipristal The metabolism of Ulipristal can be increased when combined with Lacosamide.
Levonorgestrel Levonorgestrel The metabolism of Lacosamide can be increased when combined with Levonorgestrel.
Oxymorphone Oxymorphone The risk or severity of adverse effects can be increased when Oxymorphone is combined with Lacosamide.
Tocilizumab Injection Tocilizumab Injection The metabolism of Lacosamide can be increased when combined with Tocilizumab.
Fingolimod Fingolimod Lacosamide may increase the bradycardic activities of Fingolimod.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Lacosamide.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Lacosamide.
Lurasidone Lurasidone The risk or severity of adverse effects can be increased when Lacosamide is combined with Lurasidone.
Acetaminophen Injection Acetaminophen Injection The metabolism of Lacosamide can be increased when combined with Acetaminophen.
Vilazodone Vilazodone The risk or severity of adverse effects can be increased when Lacosamide is combined with Vilazodone.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Lacosamide can be decreased when combined with Aldesleukin.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be decreased when combined with Lacosamide.
Roflumilast Roflumilast The metabolism of Lacosamide can be decreased when combined with Roflumilast.
Linagliptin Linagliptin The metabolism of Lacosamide can be decreased when combined with Linagliptin.
Rilpivirine Rilpivirine The metabolism of Lacosamide can be decreased when combined with Rilpivirine.
Telaprevir Telaprevir The metabolism of Lacosamide can be decreased when combined with Glecaprevir.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Lacosamide can be decreased when combined with Cyclophosphamide.
Abiraterone Abiraterone The metabolism of Lacosamide can be decreased when combined with Abiraterone.
Ticagrelor Ticagrelor The metabolism of Lacosamide can be decreased when combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Lacosamide can be decreased when combined with Brentuximab vedotin.
Ruxolitinib Ruxolitinib Ruxolitinib may increase the bradycardic activities of Lacosamide.
Vandetanib Vandetanib The metabolism of Vandetanib can be decreased when combined with Lacosamide.
Clobazam Clobazam The risk or severity of adverse effects can be increased when Clobazam is combined with Lacosamide.
Vemurafenib Vemurafenib The metabolism of Lacosamide can be decreased when combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Lacosamide can be decreased when combined with Vismodegib.
Ivacaftor Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Lacosamide.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Lacosamide.
Crizotinib Crizotinib The metabolism of Lacosamide can be decreased when combined with Crizotinib.
Cabergoline Cabergoline The metabolism of Lacosamide can be decreased when combined with Cabergoline.
Naloxone Injection Naloxone Injection The metabolism of Lacosamide can be decreased when combined with Naloxone.
Ezogabine Ezogabine The risk or severity of adverse effects can be increased when Tiagabine is combined with Lacosamide.
Enzalutamide Enzalutamide The metabolism of Lacosamide can be increased when combined with Enzalutamide.
Regorafenib Regorafenib The metabolism of Lacosamide can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Lacosamide can be decreased when combined with Bosutinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Lacosamide can be increased when combined with Corticotropin.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Lacosamide.
Tofacitinib Tofacitinib Lacosamide may increase the bradycardic activities of Tofacitinib.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Lacosamide.
Pomalidomide Pomalidomide The metabolism of Pomalidomide can be decreased when combined with Lacosamide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Lacosamide can be decreased when combined with Trastuzumab emtansine.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Lacosamide.
Dabrafenib Dabrafenib The serum concentration of Lacosamide can be decreased when it is combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Lacosamide can be decreased when combined with Ospemifene.
Trametinib Trametinib The metabolism of Lacosamide can be increased when combined with Trametinib.
Levomilnacipran Levomilnacipran The risk or severity of adverse effects can be increased when Lacosamide is combined with Levomilnacipran.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Lacosamide.
Perampanel Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Lacosamide.
Lomitapide Lomitapide The metabolism of Lacosamide can be decreased when combined with Lomitapide.
Ketorolac Injection Ketorolac Injection The metabolism of Lacosamide can be decreased when combined with Ketorolac.
Simeprevir Simeprevir The metabolism of Lacosamide can be decreased when combined with Simeprevir.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Lacosamide.
Apremilast Apremilast The metabolism of Lacosamide can be increased when combined with Apremilast.
Ceritinib Ceritinib Lacosamide may increase the bradycardic activities of Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Lacosamide can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The risk or severity of adverse effects can be increased when Lacosamide is combined with Eslicarbazepine.
Idelalisib Idelalisib The metabolism of Idelalisib can be decreased when combined with Lacosamide.
Testosterone Injection Testosterone Injection The metabolism of Lacosamide can be increased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Lacosamide can be decreased when combined with Oritavancin.
Vorapaxar Vorapaxar The metabolism of Vorapaxar can be decreased when combined with Lacosamide.
Hydrocodone Hydrocodone Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Suvorexant Suvorexant Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Olaparib Olaparib The metabolism of Olaparib can be decreased when combined with Lacosamide.
Methamphetamine Methamphetamine The risk or severity of adverse effects can be increased when Metamfetamine is combined with Lacosamide.
Tasimelteon Tasimelteon The risk or severity of adverse effects can be increased when Lacosamide is combined with Tasimelteon.
Lanreotide Injection Lanreotide Injection Lacosamide may increase the bradycardic activities of Lanreotide.
Nintedanib Nintedanib The metabolism of Nintedanib can be decreased when combined with Lacosamide.
Secukinumab Injection Secukinumab Injection The metabolism of Lacosamide can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The risk or severity of adverse effects can be increased when Risperidone is combined with Lacosamide.
Palbociclib Palbociclib The metabolism of Palbociclib can be decreased when combined with Lacosamide.
Lenvatinib Lenvatinib The metabolism of Lacosamide can be decreased when combined with Lenvatinib.
Naloxegol Naloxegol The metabolism of Lacosamide can be decreased when combined with Naloxegol.
Panobinostat Panobinostat The metabolism of Panobinostat can be decreased when combined with Lacosamide.
Haloperidol Injection Haloperidol Injection The risk or severity of CNS depression can be increased when Haloperidol is combined with Lacosamide.
Ivabradine Ivabradine Lacosamide may increase the bradycardic activities of Ivabradine.
Isavuconazonium Injection Isavuconazonium Injection The metabolism of Lacosamide can be increased when combined with Isavuconazonium.
Sonidegib Sonidegib The metabolism of Sonidegib can be decreased when combined with Lacosamide.
Flibanserin Flibanserin The risk or severity of adverse effects can be increased when Flibanserin is combined with Lacosamide.
Prednisolone Prednisolone The metabolism of Lacosamide can be increased when combined with Prednisolone.
Brexpiprazole Brexpiprazole The risk or severity of adverse effects can be increased when Lacosamide is combined with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The risk or severity of adverse effects can be increased when Ziprasidone is combined with Lacosamide.
Cariprazine Cariprazine The risk or severity of adverse effects can be increased when Cariprazine is combined with Lacosamide.
Cobimetinib Cobimetinib The metabolism of Lacosamide can be decreased when combined with Cobimetinib.
Trabectedin Injection Trabectedin Injection The metabolism of Lacosamide can be decreased when combined with Trabectedin.
Osimertinib Osimertinib The metabolism of Lacosamide can be decreased when combined with Osimertinib.
Alectinib Alectinib The metabolism of Alectinib can be decreased when combined with Lacosamide.
Ixazomib Ixazomib The metabolism of Ixazomib can be decreased when combined with Lacosamide.
Rifapentine Rifapentine The metabolism of Lacosamide can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Lesinurad can be increased when combined with Lacosamide.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The metabolism of Lacosamide can be decreased when combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The metabolism of Lacosamide can be increased when combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection The risk or severity of adverse effects can be increased when Brivaracetam is combined with Lacosamide.
Venetoclax Venetoclax The metabolism of Lacosamide can be decreased when combined with Venetoclax.
Cobicistat Cobicistat The metabolism of Lacosamide can be decreased when combined with Cobicistat.
Midodrine Midodrine Midodrine may increase the bradycardic activities of Lacosamide.
Pimavanserin Pimavanserin The risk or severity of adverse effects can be increased when Pimavanserin is combined with Lacosamide.
Diphenhydramine Injection Diphenhydramine Injection The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Lacosamide.
Rucaparib Rucaparib The metabolism of Lacosamide can be decreased when combined with Rucaparib.
Ribociclib Ribociclib The metabolism of Lacosamide can be decreased when combined with Ribociclib.
Brigatinib Brigatinib The metabolism of Lacosamide can be decreased when combined with Brigatinib.
Doxepin (Insomnia) Doxepin (Insomnia) Doxepin may increase the central nervous system depressant (CNS depressant) activities of Lacosamide.
Deflazacort Deflazacort The metabolism of Lacosamide can be increased when combined with Deflazacort.
Safinamide Safinamide The metabolism of Lacosamide can be decreased when combined with Safinamide.
Sarilumab Injection Sarilumab Injection The metabolism of Lacosamide can be increased when combined with Sarilumab.
Midostaurin Midostaurin The metabolism of Lacosamide can be increased when combined with Midostaurin.
Neratinib Neratinib The metabolism of Neratinib can be decreased when combined with Lacosamide.
Enasidenib Enasidenib The metabolism of Lacosamide can be decreased when combined with Enasidenib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Lacosamide can be increased when combined with Fosaprepitant.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Lacosamide.
Delafloxacin Delafloxacin The metabolism of Lacosamide can be increased when combined with Delafloxacin.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Lacosamide.
Acalabrutinib Acalabrutinib The metabolism of Lacosamide can be decreased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Lacosamide can be decreased when combined with Letermovir.
Buprenorphine Injection Buprenorphine Injection Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Apalutamide Apalutamide The serum concentration of Lacosamide can be increased when it is combined with Apalutamide.
Fostamatinib Fostamatinib The metabolism of Lacosamide can be decreased when combined with Fostamatinib.
Avatrombopag Avatrombopag The metabolism of Lacosamide can be increased when combined with Avatrombopag.
Baricitinib Baricitinib The metabolism of Baricitinib can be decreased when combined with Lacosamide.
Lofexidine Lofexidine The therapeutic efficacy of Lacosamide can be increased when used in combination with Lofexidine.
Ivosidenib Ivosidenib The metabolism of Lacosamide can be decreased when combined with Ivosidenib.
Cannabidiol Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Lacosamide.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Lacosamide.
Duvelisib Duvelisib The metabolism of Duvelisib can be decreased when combined with Lacosamide.
Stiripentol Stiripentol The metabolism of Lacosamide can be decreased when combined with Stiripentol.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be decreased when combined with Lacosamide.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Lacosamide.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Lacosamide.
Rifamycin Rifamycin The metabolism of Lacosamide can be increased when combined with Rifamycin.
Prucalopride Prucalopride The metabolism of Prucalopride can be decreased when combined with Lacosamide.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Lacosamide can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Lacosamide.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Lacosamide.
Esomeprazole Injection Esomeprazole Injection The metabolism of Lacosamide can be decreased when combined with Esomeprazole.
Alpelisib Alpelisib The serum concentration of Lacosamide can be decreased when it is combined with Alpelisib.
Brexanolone Injection Brexanolone Injection The risk or severity of adverse effects can be increased when Lacosamide is combined with Brexanolone.
Solriamfetol Solriamfetol The risk or severity of adverse effects can be increased when Lacosamide is combined with Solriamfetol.
Triclabendazole Triclabendazole The metabolism of Lacosamide can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The metabolism of Entrectinib can be decreased when combined with Lacosamide.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Lacosamide.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Lacosamide.
Pitolisant Pitolisant The serum concentration of Lacosamide can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The metabolism of Fedratinib can be decreased when combined with Lacosamide.
Lefamulin Lefamulin The metabolism of Lefamulin can be decreased when combined with Lacosamide.
Phenytoin Injection Phenytoin Injection The serum concentration of Lacosamide can be decreased when it is combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The serum concentration of Lacosamide can be decreased when it is combined with Fosphenytoin.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Lacosamide.
Voxelotor Voxelotor The metabolism of Voxelotor can be decreased when combined with Lacosamide.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Lacosamide.
Lumateperone Lumateperone The risk or severity of adverse effects can be increased when Lumateperone is combined with Lacosamide.
Lasmiditan Lasmiditan The risk or severity of adverse effects can be increased when Lacosamide is combined with Lasmiditan.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Lacosamide.
Cenobamate Cenobamate The serum concentration of Lacosamide can be decreased when it is combined with Cenobamate.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Lacosamide.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Lacosamide.
Lemborexant Lemborexant The risk or severity of adverse effects can be increased when Lacosamide is combined with Lemborexant.
Fenfluramine Fenfluramine The risk or severity of adverse effects can be increased when Fenfluramine is combined with Lacosamide.
Octreotide Octreotide The serum concentration of the active metabolites of Lacosamide can be increased when Lacosamide is used in combination with Octreotide.
Pralsetinib Pralsetinib The metabolism of Lacosamide can be increased when combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Lacosamide can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Lacosamide can be increased when combined with Drospirenone.
Viloxazine Viloxazine The risk or severity of adverse effects can be increased when Lacosamide is combined with Viloxazine.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The metabolism of Lacosamide can be increased when combined with Vitamin E.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Lacosamide.
Indomethacin Indomethacin The metabolism of Lacosamide can be decreased when combined with Indomethacin.
Mefenamic Acid Mefenamic Acid The metabolism of Lacosamide can be decreased when combined with Mefenamic acid.
Naproxen Naproxen The metabolism of Lacosamide can be decreased when combined with Naproxen.
Trazodone Trazodone The risk or severity of adverse effects can be increased when Lacosamide is combined with Trazodone.
Floxuridine Floxuridine The metabolism of Lacosamide can be decreased when combined with Floxuridine.
Phenobarbital Phenobarbital The metabolism of Lacosamide can be increased when combined with Phenobarbital.
Metaxalone Metaxalone The risk or severity of adverse effects can be increased when Metaxalone is combined with Lacosamide.
Methotrexate Injection Methotrexate Injection The metabolism of Methotrexate can be decreased when combined with Lacosamide.
Levorphanol Levorphanol The risk or severity of adverse effects can be increased when Levorphanol is combined with Lacosamide.
Primidone Primidone The metabolism of Lacosamide can be increased when combined with Primidone.
Methsuximide Methsuximide The risk or severity of adverse effects can be increased when Methsuximide is combined with Lacosamide.
Diethylpropion Diethylpropion The risk or severity of adverse effects can be increased when Diethylpropion is combined with Lacosamide.
Chlorpromazine Chlorpromazine The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Lacosamide.
Diazepam Diazepam The risk or severity of adverse effects can be increased when Diazepam is combined with Lacosamide.
Oxazepam Oxazepam The risk or severity of adverse effects can be increased when Oxazepam is combined with Lacosamide.
Flurazepam Flurazepam The risk or severity of adverse effects can be increased when Flurazepam is combined with Lacosamide.
Clorazepate Clorazepate The risk or severity of adverse effects can be increased when Clorazepic acid is combined with Lacosamide.
Lorazepam Lorazepam The risk or severity of adverse effects can be increased when Lorazepam is combined with Lacosamide.
Codeine Codeine The risk or severity of adverse effects can be increased when Codeine is combined with Lacosamide.
Meprobamate Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Lacosamide.
Chlordiazepoxide Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Lacosamide.
Bromocriptine Bromocriptine The risk or severity of adverse effects can be increased when Bromocriptine is combined with Lacosamide.
Tranylcypromine Tranylcypromine The metabolism of Lacosamide can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Lacosamide can be decreased when combined with Phenelzine.
Procarbazine Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Lacosamide.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of adverse effects can be increased when Ergoloid mesylate is combined with Lacosamide.
Tetracycline Tetracycline The metabolism of Lacosamide can be decreased when combined with Tetracycline.
Minocycline Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Lacosamide.
Prochlorperazine Prochlorperazine The risk or severity of adverse effects can be increased when Prochlorperazine is combined with Lacosamide.
Thioridazine Thioridazine The risk or severity of adverse effects can be increased when Thioridazine is combined with Lacosamide.
Trifluoperazine Trifluoperazine The risk or severity of adverse effects can be increased when Trifluoperazine is combined with Lacosamide.
Dapsone Dapsone The metabolism of Lacosamide can be decreased when combined with Dapsone.
Sulfadiazine Sulfadiazine The metabolism of Lacosamide can be decreased when combined with Sulfadiazine.
Oxycodone Oxycodone The risk or severity of adverse effects can be increased when Oxycodone is combined with Lacosamide.
Methadone Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Lacosamide.
Oxybutynin Oxybutynin The metabolism of Lacosamide can be decreased when combined with Oxybutynin.
Benztropine Benztropine Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Benzatropine.
Maprotiline Maprotiline Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Maprotiline.
Ibuprofen Ibuprofen The metabolism of Lacosamide can be decreased when combined with Ibuprofen.
Trihexyphenidyl Trihexyphenidyl Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine Orphenadrine Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Perphenazine Perphenazine The risk or severity of adverse effects can be increased when Perphenazine is combined with Lacosamide.
Fluphenazine Fluphenazine The risk or severity of adverse effects can be increased when Fluphenazine is combined with Lacosamide.
Phentermine Phentermine The metabolism of Lacosamide can be decreased when combined with Phentermine.
Methylphenidate Methylphenidate The therapeutic efficacy of Lacosamide can be decreased when used in combination with Methylphenidate.
Amoxapine Amoxapine Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Amoxapine.
Hydrocortisone Hydrocortisone The metabolism of Lacosamide can be increased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The metabolism of Lacosamide can be decreased when combined with Doxorubicin.
Carbamazepine Carbamazepine The serum concentration of Lacosamide can be decreased when it is combined with Carbamazepine.
Molindone Molindone The risk or severity of adverse effects can be increased when Molindone is combined with Lacosamide.
Methyldopa Methyldopa Methyldopa may increase the bradycardic activities of Lacosamide.
Clonidine Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Lacosamide.
Hydralazine Hydralazine The metabolism of Lacosamide can be decreased when combined with Hydralazine.
Cimetidine Cimetidine The metabolism of Lacosamide can be decreased when combined with Cimetidine.
Warfarin Warfarin The metabolism of Warfarin can be decreased when combined with Lacosamide.
Clonazepam Clonazepam The risk or severity of adverse effects can be increased when Clonazepam is combined with Lacosamide.
Loperamide Loperamide The metabolism of Lacosamide can be decreased when combined with Loperamide.
Promethazine Promethazine The risk or severity of adverse effects can be increased when Promethazine is combined with Lacosamide.
Daunorubicin Daunorubicin The metabolism of Lacosamide can be decreased when combined with Daunorubicin.
Griseofulvin Griseofulvin The metabolism of Lacosamide can be increased when combined with Griseofulvin.
Digoxin Digoxin Digoxin may increase the bradycardic activities of Lacosamide.
Loxapine Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Lacosamide.
Chloroquine Chloroquine The therapeutic efficacy of Lacosamide can be decreased when used in combination with Chloroquine.
Quinine Quinine The metabolism of Lacosamide can be decreased when combined with Quinine.
Ethosuximide Ethosuximide The risk or severity of adverse effects can be increased when Ethosuximide is combined with Lacosamide.
Calcitriol Calcitriol The metabolism of Lacosamide can be increased when combined with Calcitriol.
Sulfinpyrazone Sulfinpyrazone The metabolism of Lacosamide can be decreased when combined with Sulfinpyrazone.
Isosorbide Isosorbide The metabolism of Isosorbide can be increased when combined with Lacosamide.
Secobarbital Secobarbital The risk or severity of adverse effects can be increased when Secobarbital is combined with Lacosamide.
Desipramine Desipramine Desipramine may increase the central nervous system depressant (CNS depressant) activities of Lacosamide.
Amitriptyline Amitriptyline Amitriptyline may increase the central nervous system depressant (CNS depressant) activities of Lacosamide.
Imipramine Imipramine The metabolism of Imipramine can be decreased when combined with Lacosamide.
Probenecid Probenecid The metabolism of Lacosamide can be decreased when combined with Probenecid.
Quinidine Quinidine The metabolism of Quinidine can be decreased when combined with Lacosamide.
Isoniazid Isoniazid The metabolism of Lacosamide can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Rifampicin can be increased when combined with Lacosamide.
Disopyramide Disopyramide Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Disopyramide.
Valproic Acid Valproic Acid The risk or severity of adverse effects can be increased when Valproic acid is combined with Lacosamide.
Tamoxifen Tamoxifen The metabolism of Lacosamide can be decreased when combined with Tamoxifen.
Butabarbital Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Lacosamide.
Methimazole Methimazole The metabolism of Lacosamide can be decreased when combined with Methimazole.
Chlorpropamide Chlorpropamide The metabolism of Lacosamide can be decreased when combined with Chlorpropamide.
Tolbutamide Tolbutamide The metabolism of Lacosamide can be decreased when combined with Tolbutamide.
Tolazamide Tolazamide The metabolism of Lacosamide can be decreased when combined with Tolazamide.
Dextromethorphan Dextromethorphan The risk or severity of adverse effects can be increased when Dextromethorphan is combined with Lacosamide.
Cyclobenzaprine Cyclobenzaprine The risk or severity of CNS depression can be increased when Lacosamide is combined with Cyclobenzaprine.
Niacin Niacin The metabolism of Lacosamide can be decreased when combined with Niacin.
Baclofen Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Lacosamide.
Doxylamine Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Lacosamide.
Cyproheptadine Cyproheptadine Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.
Clemastine Clemastine The risk or severity of adverse effects can be increased when Clemastine is combined with Lacosamide.
Chlorpheniramine Chlorpheniramine The risk or severity of adverse effects can be increased when Chlorpheniramine is combined with Lacosamide.
Brompheniramine Brompheniramine The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Lacosamide.
Meclizine Meclizine The risk or severity of adverse effects can be increased when Meclizine is combined with Lacosamide.
Dantrolene Dantrolene The risk or severity of adverse effects can be increased when Dantrolene is combined with Lacosamide.
Chlorzoxazone Chlorzoxazone The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Lacosamide.
Carisoprodol Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Lacosamide.
Methocarbamol Methocarbamol The risk or severity of adverse effects can be increased when Methocarbamol is combined with Lacosamide.
Danazol Danazol The metabolism of Lacosamide can be decreased when combined with Danazol.
Disulfiram Disulfiram The therapeutic efficacy of Lacosamide can be decreased when used in combination with Disulfiram.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Lacosamide can be decreased when combined with Propranolol.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be decreased when combined with Lacosamide.
Amphotericin B Injection Amphotericin B Injection The metabolism of Lacosamide can be decreased when combined with Amphotericin B.
Mercaptopurine Mercaptopurine Lacosamide may increase the excretion rate of Mercaptopurine which could result in a lower serum level and potentially a reduction in efficacy.
Nadolol Nadolol Nadolol may increase the bradycardic activities of Lacosamide.
Butorphanol Injection Butorphanol Injection The risk or severity of adverse effects can be increased when Butorphanol is combined with Lacosamide.
Nalbuphine Injection Nalbuphine Injection The risk or severity of adverse effects can be increased when Nalbuphine is combined with Lacosamide.
Trimethobenzamide Trimethobenzamide The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Lacosamide.
Flavoxate Flavoxate Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
Fluorouracil Injection Fluorouracil Injection The metabolism of Lacosamide can be decreased when combined with Fluorouracil.
Colchicine Colchicine The metabolism of Lacosamide can be increased when combined with Colchicine.
Cephalexin Cephalexin The metabolism of Lacosamide can be decreased when combined with Cephalexin.
Acetazolamide Acetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Lacosamide.
Cefotaxime Injection Cefotaxime Injection The therapeutic efficacy of Lacosamide can be decreased when used in combination with Cefotaxime.
Ketoconazole Ketoconazole The metabolism of Lacosamide can be decreased when combined with Ketoconazole.
Pyrantel Pyrantel The risk or severity of adverse effects can be increased when Lacosamide is combined with Pyrantel.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Lacosamide.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be decreased when combined with Lacosamide.
Vinblastine Vinblastine The metabolism of Lacosamide can be decreased when combined with Vinblastine.
Metoprolol Metoprolol The metabolism of Lacosamide can be decreased when combined with Metoprolol.
Hydroxyzine Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Lacosamide.
Thiothixene Thiothixene The risk or severity of adverse effects can be increased when Thiothixene is combined with Lacosamide.
Aspirin Aspirin The metabolism of Lacosamide can be decreased when combined with Acetylsalicylic acid.
Chlorambucil Chlorambucil The therapeutic efficacy of Lacosamide can be decreased when used in combination with Chlorambucil.
Alprazolam Alprazolam The risk or severity of adverse effects can be increased when Alprazolam is combined with Lacosamide.
Temazepam Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Lacosamide.
Triazolam Triazolam The risk or severity of adverse effects can be increased when Triazolam is combined with Lacosamide.
Dicyclomine Dicyclomine Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
Hyoscyamine Hyoscyamine Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
Propantheline Propantheline Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
Trimethoprim Trimethoprim The metabolism of Lacosamide can be decreased when combined with Trimethoprim.
Diltiazem Diltiazem The metabolism of Lacosamide can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Lacosamide can be increased when combined with Nifedipine.
Timolol Timolol The metabolism of Lacosamide can be decreased when combined with Timolol.
Verapamil Verapamil The metabolism of Lacosamide can be decreased when combined with Verapamil.
Atenolol Atenolol Atenolol may increase the bradycardic activities of Lacosamide.
Pindolol Pindolol The risk or severity of adverse effects can be increased when Pindolol is combined with Lacosamide.
Cisplatin Injection Cisplatin Injection The metabolism of Lacosamide can be decreased when combined with Cisplatin.
Piroxicam Piroxicam The metabolism of Lacosamide can be decreased when combined with Piroxicam.
Etoposide Etoposide The metabolism of Lacosamide can be decreased when combined with Etoposide.
Glyburide Glyburide The metabolism of Lacosamide can be decreased when combined with Glyburide.
Glipizide Glipizide The metabolism of Lacosamide can be decreased when combined with Glipizide.
Dicloxacillin Dicloxacillin The metabolism of Lacosamide can be increased when combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The metabolism of Lacosamide can be increased when combined with Nafcillin.
Pentoxifylline Pentoxifylline Lacosamide may increase the excretion rate of Pentoxifylline which could result in a lower serum level and potentially a reduction in efficacy.
Labetalol Labetalol The metabolism of Lacosamide can be decreased when combined with Labetalol.
Gemfibrozil Gemfibrozil The metabolism of Lacosamide can be decreased when combined with Gemfibrozil.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Lacosamide.
Flurbiprofen Flurbiprofen The metabolism of Lacosamide can be decreased when combined with Flurbiprofen.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Lacosamide.
Lovastatin Lovastatin The metabolism of Lacosamide can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The metabolism of Lacosamide can be decreased when combined with Ciprofloxacin.
Diclofenac Diclofenac The metabolism of Lacosamide can be decreased when combined with Diclofenac.
Fluoxetine Fluoxetine Fluoxetine may increase the central nervous system depressant (CNS depressant) activities of Lacosamide.
Nimodipine Nimodipine Nimodipine may increase the bradycardic activities of Lacosamide.
Clozapine Clozapine Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Clozapine.
Estazolam Estazolam The risk or severity of adverse effects can be increased when Estazolam is combined with Lacosamide.
Idarubicin Idarubicin The metabolism of Lacosamide can be decreased when combined with Idarubicin.
Clarithromycin Clarithromycin The metabolism of Lacosamide can be decreased when combined with Clarithromycin.
Etodolac Etodolac The metabolism of Lacosamide can be decreased when combined with Etodolac.
Felodipine Felodipine The metabolism of Lacosamide can be decreased when combined with Felodipine.
Nabumetone Nabumetone The metabolism of Lacosamide can be decreased when combined with Nabumetone.
Simvastatin Simvastatin The metabolism of Lacosamide can be decreased when combined with Simvastatin.
Amlodipine Amlodipine Amlodipine may increase the bradycardic activities of Lacosamide.
Teniposide Injection Teniposide Injection The metabolism of Lacosamide can be decreased when combined with Teniposide.
Itraconazole Itraconazole The metabolism of Lacosamide can be decreased when combined with Itraconazole.
Atovaquone Atovaquone The metabolism of Lacosamide can be decreased when combined with Atovaquone.
Rifabutin Rifabutin The metabolism of Lacosamide can be increased when combined with Rifabutin.
Sotalol Sotalol Sotalol may increase the bradycardic activities of Lacosamide.
Bisoprolol Bisoprolol Bisoprolol may increase the bradycardic activities of Lacosamide.
Zolpidem Zolpidem Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin Doxazosin The metabolism of Lacosamide can be decreased when combined with Doxazosin.
Isradipine Isradipine The metabolism of Lacosamide can be decreased when combined with Isradipine.
Omeprazole Omeprazole The metabolism of Lacosamide can be decreased when combined with Omeprazole.
Cisapride Cisapride The risk or severity of adverse effects can be increased when Cisapride is combined with Lacosamide.
Gabapentin Gabapentin The risk or severity of adverse effects can be increased when Gabapentin is combined with Lacosamide.
Fluvastatin Fluvastatin The metabolism of Lacosamide can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The risk or severity of adverse effects can be increased when Venlafaxine is combined with Lacosamide.
Famciclovir Famciclovir The metabolism of Lacosamide can be decreased when combined with Famciclovir.
Fluvoxamine Fluvoxamine The metabolism of Lacosamide can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The metabolism of Lacosamide can be decreased when combined with Nefazodone.
Lamotrigine Lamotrigine The risk or severity of adverse effects can be increased when Lamotrigine is combined with Lacosamide.
Losartan Losartan The metabolism of Lacosamide can be decreased when combined with Losartan.
Tramadol Tramadol The risk or severity of CNS depression can be increased when Lacosamide is combined with Tramadol.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be decreased when combined with Lacosamide.
Lansoprazole Lansoprazole The metabolism of Lacosamide can be decreased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Lacosamide can be decreased when combined with Ifosfamide.
Nicardipine Nicardipine The metabolism of Lacosamide can be decreased when combined with Nicardipine.
Bupropion Bupropion The risk or severity of adverse effects can be increased when Bupropion is combined with Lacosamide.
Ticlopidine Ticlopidine The metabolism of Lacosamide can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The metabolism of Saquinavir can be decreased when combined with Lacosamide.
Nisoldipine Nisoldipine Nisoldipine may increase the bradycardic activities of Lacosamide.
Riluzole Riluzole The risk or severity of adverse effects can be increased when Riluzole is combined with Lacosamide.
Glimepiride Glimepiride The metabolism of Lacosamide can be decreased when combined with Glimepiride.
Ritonavir Ritonavir The serum concentration of Lacosamide can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Lacosamide can be decreased when combined with Docetaxel.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Lacosamide.
Zafirlukast Zafirlukast The metabolism of Lacosamide can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Topiramate Topiramate The risk or severity of adverse effects can be increased when Topiramate is combined with Lacosamide.
Zileuton Zileuton The metabolism of Lacosamide can be decreased when combined with Zileuton.
Valsartan Valsartan The metabolism of Lacosamide can be decreased when combined with Valsartan.
Pramipexole Pramipexole Lacosamide may increase the sedative activities of Pramipexole.
Donepezil Donepezil The risk or severity of adverse effects can be increased when Donepezil is combined with Lacosamide.
Nelfinavir Nelfinavir The metabolism of Lacosamide can be decreased when combined with Nelfinavir.
Azithromycin Azithromycin The metabolism of Lacosamide can be decreased when combined with Azithromycin.
Carvedilol Carvedilol Carvedilol may increase the bradycardic activities of Lacosamide.
Nilutamide Nilutamide The metabolism of Lacosamide can be decreased when combined with Nilutamide.
Selegiline Selegiline The risk or severity of adverse effects can be increased when Selegiline is combined with Lacosamide.
Bicalutamide Bicalutamide The metabolism of Lacosamide can be decreased when combined with Bicalutamide.
Sertraline Sertraline The risk or severity of adverse effects can be increased when Lacosamide is combined with Sertraline.
Propafenone Propafenone Propafenone may increase the bradycardic activities of Lacosamide.
Letrozole Letrozole The metabolism of Lacosamide can be decreased when combined with Letrozole.
Raloxifene Raloxifene The metabolism of Lacosamide can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Lacosamide can be decreased when combined with Irbesartan.
Ropinirole Ropinirole Lacosamide may increase the sedative activities of Ropinirole.
Quetiapine Quetiapine Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.
Cetirizine Cetirizine The risk or severity of adverse effects can be increased when Cetirizine is combined with Lacosamide.
Paroxetine Paroxetine The risk or severity of adverse effects can be increased when Lacosamide is combined with Paroxetine.
Tolcapone Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Lacosamide.
Citalopram Citalopram The risk or severity of adverse effects can be increased when Lacosamide is combined with Citalopram.
Capecitabine Capecitabine The metabolism of Lacosamide can be decreased when combined with Capecitabine.
Efavirenz Efavirenz The metabolism of Lacosamide can be decreased when combined with Efavirenz.
Sildenafil Sildenafil The metabolism of Lacosamide can be decreased when combined with Sildenafil.
Celecoxib Celecoxib The metabolism of Lacosamide can be decreased when combined with Celecoxib.
Rosiglitazone Rosiglitazone The metabolism of Lacosamide can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Tolterodine.
Thalidomide Thalidomide Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Nateglinide Nateglinide The metabolism of Lacosamide can be decreased when combined with Nateglinide.
Galantamine Galantamine Galantamine may increase the bradycardic activities of Lacosamide.
Levetiracetam Levetiracetam The risk or severity of adverse effects can be increased when Levetiracetam is combined with Lacosamide.
Rabeprazole Rabeprazole The metabolism of Lacosamide can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Lacosamide can be increased when combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists