Zonisamide

Zonisamide is used in combination with other medications to treat certain types of seizures. Zonisamide is in a class of medications called anticonvulsants. It works by decreasing abnormal electrical activity in the brain.

Zonisamide comes as a capsule to take by mouth. It is usually taken once or twice a day with or without food. To help you remember to take zonisamide, take it at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take zonisamide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole; do not split, chew, or crush them.

Your doctor will probably start you on a low dose of zonisamide and gradually increase your dose, not more often than once every 2 weeks.

Zonisamide may help control your condition but will not cure it. It may take 2 weeks or longer before you feel the full benefit of zonisamide. Continue to take zonisamide even if you feel well. Do not stop taking zonisamide without talking to your doctor, even if you experience side effects such as unusual changes in behavior or mood. If you suddenly stop taking zonisamide, your seizures may become worse. Your doctor will probably decrease your dose gradually.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with zonisamide and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking zonisamide,

• tell your doctor and pharmacist if you are allergic to zonisamide, diuretics ('water pills'), oral medications for diabetes, sulfa drugs, or any other medications.

• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Pacerone);antifungals such as itraconazole (Sporanox) and ketoconazole (Nizoral); carbonic anhydrase inhibitors such as acetazolamide (Diamox) and methazolamide; clarithromycin (Biaxin, in Prevpac); diltiazem (Cardizem, Dilacor, Tiazac); erythromycin (E.E.S., E-Mycin, Erythrocin); fluvoxamine (Luvox); HIV protease inhibitors such as indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir, in Kaletra); medications for irritable bowel disease, motion sickness, Parkinson's disease, ulcers, or urinary problems; other medications for seizures including carbamazepine (Carbatrol, Epitol, Tegretol),phenobarbital (Luminal, Solfoton), phenytoin (Dilantin, Phenytek),and valproic acid (Depakene, Depakote); nefazodone (Serzone); hormonal contraceptives (birth control pills, patches, rings, and injections); pioglitazone (Actos, in Actoplus, in Duetact); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane); troleandomycin (TAO) (not available in the U.S.); and verapamil (Calan, Covera, Isoptin, Verelan). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

• tell your doctor what herbal products you are taking, especially St. John's wort.

• tell your doctor if you are following a ketogenic diet (a high fat, low carbohydrate diet used to control seizures) or if you have or have ever had breathing problems, kidney liver, or lung disease. Also tell your doctor if you have diarrhea now, or if you develop diarrhea at any time during your treatment.

• tell your doctor if you are pregnant or plan to become pregnant. You should use birth control to prevent pregnancy during your treatment. Talk to your doctor about birth control methods that will work for you. If you become pregnant while taking zonisamide, call your doctor.

• tell your doctor if you are breast-feeding. If you breast-feed during your treatment, your baby may receive some zonisamide in the breast milk. Watch your baby closely for unusual sleepiness or poor weight gain.

• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking zonisamide.

• you should know that zonisamide may make you drowsy. Do not drive a car, operate machinery, or perform dangerous tasks until you know how this medication affects you.

• you should know that zonisamide can decrease the body's ability to sweat and make it harder for your body to cool down when it gets very hot. This happens most often in warm weather and to children who take zonisamide. (Children should not normally take zonisamide, but in some cases, it may be prescribed by a doctor.) You should avoid exposure to heat and call your doctor right away if you have a fever and/or are not sweating as usual.

• you should know that your mental health may change in unexpected ways and you may become suicidal (thinking about harming or killing yourself or planning or trying to do so) while you are taking zonisamide for the treatment of epilepsy, mental illness, or other conditions. A small number of adults and children 5 years of age and older (about 1 in 500 people) who took anticonvulsants such as zonisamide to treat various conditions during clinical studies became suicidal during their treatment. Some of these people developed suicidal thoughts and behavior as early as 1 week after they started taking the medication. There is a risk that you may experience changes in your mental health if you take an anticonvulsants medication such as zonisamide, but there may also be a risk that you will experience changes in your mental health if your condition is not treated. You and your doctor will decide whether the risks of taking an anticonvulsant medication are greater than the risks of not taking the medication. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: panic attacks; agitation or restlessness; new or worsening irritability, anxiety, or depression; acting on dangerous impulses; difficulty falling or staying asleep; aggressive, angry, or violent behavior; mania (frenzied, abnormally excited mood); talking or thinking about wanting to hurt yourself or end your life; withdrawing from friends and family; preoccupation with death and dying; giving away prized possessions; or any other unusual changes in behavior or mood. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.

Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine.

Drink 6-8 glasses of water every day during your treatment with zonisamide.

Talk to your doctor about what to do if you miss a dose of zonisamide. Do not take a double dose to make up for a missed one.

• Zonisamide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea

  • vomiting

  • weight loss

  • changes in taste

  • diarrhea

  • constipation

  • heartburn

  • dry mouth

  • headache

  • dizziness

  • confusion

  • irritability

  • difficulty falling asleep or staying asleep

  • difficulty with memory

  • pain, burning, numbness, or tingling in the hands or feet

  • uncontrollable eye movements

  • double vision

• Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:

  • rash

  • blistering or peeling of skin

  • worsening or longer-lasting seizures

  • sudden back pain

  • stomach pain

  • pain when urinating

  • bloody or dark urine

  • fever, sore throat, chills, cough, and other signs of infection

  • sores in mouth

  • easy bruising

  • difficulty thinking of words or trouble speaking

  • difficulty thinking or concentrating

  • lack of coordination

  • difficulty walking

  • severe weakness

  • severe muscle pain

  • extreme tiredness

  • loss of appetite

  • fast, shallow breathing

  • irregular heartbeat

  • loss of consciousness

• Zonisamide may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

• Zonisamide may cause metabolic acidosis (abnormally low levels of a certain natural substance in the blood). Metabolic acidosis that is left untreated for a long time may increase the risk that other medical problems, including kidney stones and bone problems that may lead to fractures, will develop. Untreated metabolic acidosis may also cause slowed growth and a decrease in final height in children. Talk to your doctor about the risks of taking zonisamide.

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

• slow heartbeat

• slowed breathing

• dizziness

• fainting

• coma (loss of consciousness for a period of time)

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to zonisamide.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug	Interaction
Moxifloxacin	Moxifloxacin The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Moxifloxacin.
Repaglinide	Repaglinide The therapeutic efficacy of Repaglinide can be increased when used in combination with Zonisamide.
Insulin Glargine (rDNA origin) Injection	Insulin Glargine (rDNA origin) Injection The therapeutic efficacy of Insulin glargine can be increased when used in combination with Zonisamide.
Delavirdine	Delavirdine The metabolism of Zonisamide can be decreased when combined with Delavirdine.
Nevirapine	Nevirapine The metabolism of Zonisamide can be decreased when combined with Nevirapine.
Atorvastatin	Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Zonisamide.
Dolasetron	Dolasetron The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Dolasetron.
Aminophylline	Aminophylline Zonisamide may increase the excretion rate of Aminophylline which could result in a lower serum level and potentially a reduction in efficacy.
Anagrelide	Anagrelide The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Anagrelide.
Bisacodyl	Bisacodyl The risk or severity of adverse effects can be increased when Zonisamide is combined with Bisacodyl.
Candesartan	Candesartan The risk or severity of hyperkalemia can be increased when Zonisamide is combined with Candesartan.
Cilostazol	Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Zonisamide.
Clopidogrel	Clopidogrel The therapeutic efficacy of Clopidogrel can be decreased when used in combination with Zonisamide.
Diphenoxylate	Diphenoxylate The risk or severity of adverse effects can be increased when Zonisamide is combined with Diphenoxylate.
Erythromycin and Sulfisoxazole	Erythromycin and Sulfisoxazole The risk or severity of QTc prolongation and hypotension can be increased when Erythromycin is combined with Zonisamide.
Estrogen and Progestin (Oral Contraceptives)	Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Fenofibrate	Fenofibrate Zonisamide may increase the excretion rate of Fenofibrate which could result in a lower serum level and potentially a reduction in efficacy.
Guanfacine	Guanfacine The risk or severity of adverse effects can be increased when Zonisamide is combined with Guanfacine.
Magnesium Gluconate	Magnesium Gluconate The risk or severity of hypotension can be increased when Zonisamide is combined with Magnesium gluconate.
Magnesium Hydroxide	Magnesium Hydroxide The risk or severity of hypotension can be increased when Zonisamide is combined with Magnesium hydroxide.
Magnesium Oxide	Magnesium Oxide The risk or severity of hypotension can be increased when Zonisamide is combined with Magnesium oxide.
Miglitol	Miglitol The therapeutic efficacy of Miglitol can be increased when used in combination with Zonisamide.
Mycophenolate	Mycophenolate Zonisamide may increase the excretion rate of Mycophenolic acid which could result in a lower serum level and potentially a reduction in efficacy.
Naratriptan	Naratriptan The metabolism of Naratriptan can be decreased when combined with Zonisamide.
Olsalazine	Olsalazine The risk or severity of adverse effects can be increased when Olsalazine is combined with Zonisamide.
Paregoric	Paregoric The risk or severity of adverse effects can be increased when Morphine is combined with Zonisamide.
Penbutolol	Penbutolol The risk or severity of bradycardia can be increased when Zonisamide is combined with Acebutolol.
Pentazocine	Pentazocine The risk or severity of adverse effects can be increased when Pentazocine is combined with Zonisamide.
Polyethylene glycol-electrolyte solution (PEG-ES)	Polyethylene glycol-electrolyte solution (PEG-ES) The risk or severity of adverse effects can be increased when Zonisamide is combined with Polyethylene glycol.
Potassium	Potassium Potassium may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone	Prednisone Prednisone may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Psyllium	Psyllium The risk or severity of adverse effects can be increased when Zonisamide is combined with Plantago seed.
Ranitidine	Ranitidine Ranitidine may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Reserpine	Reserpine The risk or severity of adverse effects can be increased when Reserpine is combined with Zonisamide.
Rizatriptan	Rizatriptan The metabolism of Rizatriptan can be decreased when combined with Zonisamide.
Sumatriptan	Sumatriptan The metabolism of Sumatriptan can be decreased when combined with Zonisamide.
Tacrolimus	Tacrolimus Zonisamide may increase the immunosuppressive activities of Tacrolimus.
Tizanidine	Tizanidine The risk or severity of adverse effects can be increased when Tizanidine is combined with Zonisamide.
Triamcinolone	Triamcinolone The metabolism of Zonisamide can be increased when combined with Triamcinolone.
Zolmitriptan	Zolmitriptan The metabolism of Zolmitriptan can be decreased when combined with Zonisamide.
Ampicillin Injection	Ampicillin Injection Ampicillin may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Doxycycline Injection	Doxycycline Injection Doxycycline may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Famotidine Injection	Famotidine Injection The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Famotidine.
Fluconazole Injection	Fluconazole Injection The metabolism of Zonisamide can be decreased when combined with Fluconazole.
Foscarnet Injection	Foscarnet Injection Foscarnet may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Hydromorphone Injection	Hydromorphone Injection The risk or severity of adverse effects can be increased when Hydromorphone is combined with Zonisamide.
Levofloxacin Injection	Levofloxacin Injection Zonisamide may increase the excretion rate of Levofloxacin which could result in a lower serum level and potentially a reduction in efficacy.
Meperidine Injection	Meperidine Injection The risk or severity of adverse effects can be increased when Meperidine is combined with Zonisamide.
Metoclopramide Injection	Metoclopramide Injection The risk or severity of sedation can be increased when Zonisamide is combined with Metoclopramide.
Metronidazole Injection	Metronidazole Injection The therapeutic efficacy of Metronidazole can be decreased when used in combination with Zonisamide.
Morphine Injection	Morphine Injection The risk or severity of adverse effects can be increased when Morphine is combined with Zonisamide.
Pamidronate Injection	Pamidronate Injection Pamidronic acid may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Vancomycin Injection	Vancomycin Injection Zonisamide may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection	Zidovudine Injection The metabolism of Zonisamide can be increased when combined with Zidovudine.
Altretamine	Altretamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Zonisamide.
Cefuroxime	Cefuroxime Cefuroxime may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Cyclosporine	Cyclosporine The risk or severity of renal failure can be increased when Zonisamide is combined with Cyclosporine.
Ondansetron	Ondansetron The risk or severity of adverse effects can be increased when Ondansetron is combined with Zonisamide.
Enoxaparin Injection	Enoxaparin Injection The risk or severity of hyperkalemia can be increased when Zonisamide is combined with Enoxaparin.
Granisetron	Granisetron The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Granisetron.
Torsemide	Torsemide Torasemide may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Olanzapine	Olanzapine The risk or severity of adverse effects can be increased when Olanzapine is combined with Zonisamide.
Alosetron	Alosetron The risk or severity of adverse effects can be increased when Zonisamide is combined with Alosetron.
Dofetilide	Dofetilide Zonisamide may increase the arrhythmogenic activities of Dofetilide.
Entacapone	Entacapone The risk or severity of adverse effects can be increased when Entacapone is combined with Zonisamide.
Eprosartan	Eprosartan The risk or severity of hyperkalemia can be increased when Eprosartan is combined with Zonisamide.
Hydroxychloroquine	Hydroxychloroquine The therapeutic efficacy of Hydroxychloroquine can be decreased when used in combination with Zonisamide.
Meloxicam	Meloxicam The therapeutic efficacy of Zonisamide can be decreased when used in combination with Meloxicam.
Orlistat	Orlistat Orlistat can cause a decrease in the absorption of Zonisamide resulting in a reduced serum concentration and potentially a decrease in efficacy.
Oxcarbazepine	Oxcarbazepine The metabolism of Zonisamide can be increased when combined with Oxcarbazepine.
Pantoprazole	Pantoprazole The metabolism of Zonisamide can be decreased when combined with Pantoprazole.
Sevelamer	Sevelamer Sevelamer can cause a decrease in the absorption of Zonisamide resulting in a reduced serum concentration and potentially a decrease in efficacy.
Telmisartan	Telmisartan The metabolism of Zonisamide can be decreased when combined with Telmisartan.
Temozolomide	Temozolomide Temozolomide may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Zaleplon	Zaleplon The risk or severity of adverse effects can be increased when Zonisamide is combined with Zaleplon.
Anakinra	Anakinra The metabolism of Zonisamide can be increased when combined with Anakinra.
Desloratadine	Desloratadine The risk or severity of adverse effects can be increased when Zonisamide is combined with Desloratadine.
Linezolid	Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Zonisamide.
Rivastigmine	Rivastigmine Zonisamide may increase the bradycardic activities of Rivastigmine.
Trimipramine	Trimipramine The serum concentration of Zonisamide can be increased when it is combined with Trimipramine.
Etanercept Injection	Etanercept Injection The metabolism of Zonisamide can be increased when combined with Etanercept.
Glycopyrrolate	Glycopyrrolate Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
Modafinil	Modafinil The metabolism of Zonisamide can be decreased when combined with Modafinil.
Perindopril	Perindopril Perindopril may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Tenofovir	Tenofovir Tenofovir may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Choline Magnesium Trisalicylate	Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Sirolimus	Sirolimus Zonisamide may increase the immunosuppressive activities of Sirolimus.
Dutasteride	Dutasteride The metabolism of Dutasteride can be decreased when combined with Zonisamide.
Epinephrine Injection	Epinephrine Injection The risk or severity of Cardiac Arrhythmia can be increased when Epinephrine is combined with Zonisamide.
Eplerenone	Eplerenone Eplerenone may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Escitalopram	Escitalopram The risk or severity of adverse effects can be increased when Zonisamide is combined with Escitalopram.
Olmesartan	Olmesartan The risk or severity of hyperkalemia can be increased when Olmesartan is combined with Zonisamide.
Adalimumab Injection	Adalimumab Injection The metabolism of Zonisamide can be increased when combined with Adalimumab.
Aripiprazole	Aripiprazole The risk or severity of adverse effects can be increased when Zonisamide is combined with Aripiprazole.
Atomoxetine	Atomoxetine The risk or severity of adverse effects can be increased when Atomoxetine is combined with Zonisamide.
Dexmethylphenidate	Dexmethylphenidate The risk or severity of adverse effects can be increased when Zonisamide is combined with Dexmethylphenidate.
Atazanavir	Atazanavir Atazanavir may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Almotriptan	Almotriptan The metabolism of Almotriptan can be decreased when combined with Zonisamide.
Eletriptan	Eletriptan The risk or severity of adverse effects can be increased when Eletriptan is combined with Zonisamide.
Mefloquine	Mefloquine The therapeutic efficacy of Zonisamide can be decreased when used in combination with Mefloquine.
Polyethylene Glycol 3350	Polyethylene Glycol 3350 The risk or severity of adverse effects can be increased when Zonisamide is combined with Polyethylene glycol.
Rosuvastatin	Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Zonisamide.
Vardenafil	Vardenafil The serum concentration of Vardenafil can be increased when it is combined with Zonisamide.
Alfuzosin	Alfuzosin The risk or severity of hypotension can be increased when Alfuzosin is combined with Zonisamide.
Aprepitant	Aprepitant The metabolism of Zonisamide can be decreased when combined with Aprepitant.
Emtricitabine	Emtricitabine Emtricitabine may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Memantine	Memantine The excretion of Memantine can be decreased when combined with Zonisamide.
Tegaserod	Tegaserod The serum concentration of Tegaserod can be increased when it is combined with Zonisamide.
Tadalafil	Tadalafil Tadalafil may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Frovatriptan	Frovatriptan The risk or severity of adverse effects can be increased when Zonisamide is combined with Frovatriptan.
Gemifloxacin	Gemifloxacin The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Gemifloxacin.
Progesterone	Progesterone The metabolism of Progesterone can be increased when combined with Zonisamide.
Apomorphine Injection	Apomorphine Injection The risk or severity of adverse effects can be increased when Apomorphine is combined with Zonisamide.
Infliximab Injection	Infliximab Injection The metabolism of Zonisamide can be increased when combined with Infliximab.
Protriptyline	Protriptyline The risk or severity of adverse effects can be increased when Protriptyline is combined with Zonisamide.
Rifaximin	Rifaximin The serum concentration of Rifaximin can be increased when it is combined with Zonisamide.
Duloxetine	Duloxetine The risk or severity of adverse effects can be increased when Zonisamide is combined with Duloxetine.
Norethindrone	Norethindrone The metabolism of Zonisamide can be increased when combined with Norethisterone.
Tinidazole	Tinidazole Zonisamide may increase the excretion rate of Tinidazole which could result in a lower serum level and potentially a reduction in efficacy.
Trospium	Trospium Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Cefditoren	Cefditoren Cefdinir may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Cyanocobalamin Injection	Cyanocobalamin Injection Hydroxocobalamin may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Erlotinib	Erlotinib The metabolism of Erlotinib can be decreased when combined with Zonisamide.
Eszopiclone	Eszopiclone The risk or severity of CNS depression can be increased when Zonisamide is combined with Eszopiclone.
Ganciclovir	Ganciclovir Zonisamide may increase the excretion rate of Ganciclovir which could result in a lower serum level and potentially a reduction in efficacy.
Insulin Aspart (rDNA Origin) Injection	Insulin Aspart (rDNA Origin) Injection The therapeutic efficacy of Insulin aspart can be increased when used in combination with Zonisamide.
Ribavirin	Ribavirin Ribavirin may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Solifenacin	Solifenacin Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Solifenacin.
Valganciclovir	Valganciclovir Zonisamide may increase the excretion rate of Valganciclovir which could result in a lower serum level and potentially a reduction in efficacy.
Voriconazole	Voriconazole The metabolism of Zonisamide can be decreased when combined with Voriconazole.
Adefovir	Adefovir Adefovir may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Dextroamphetamine	Dextroamphetamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Zonisamide.
Pramlintide Injection	Pramlintide Injection The therapeutic efficacy of Pramlintide can be increased when used in combination with Zonisamide.
Sodium Oxybate	Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Zonisamide.
Exenatide Injection	Exenatide Injection The therapeutic efficacy of Exenatide can be increased when used in combination with Zonisamide.
Ibandronate	Ibandronate The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Zonisamide.
Isocarboxazid	Isocarboxazid The risk or severity of adverse effects can be increased when Zonisamide is combined with Isocarboxazid.
Ramelteon	Ramelteon The risk or severity of adverse effects can be increased when Zonisamide is combined with Ramelteon.
Darifenacin	Darifenacin Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Darifenacin.
Fentanyl	Fentanyl The risk or severity of adverse effects can be increased when Fentanyl is combined with Zonisamide.
Pregabalin	Pregabalin The therapeutic efficacy of Zonisamide can be increased when used in combination with Pregabalin.
Deferasirox	Deferasirox The metabolism of Zonisamide can be decreased when combined with Deferasirox.
Phenylephrine	Phenylephrine The risk or severity of hypertension can be decreased when Zonisamide is combined with Phenylephrine.
Tipranavir	Tipranavir The metabolism of Zonisamide can be decreased when combined with Tipranavir.
Felbamate	Felbamate The risk or severity of adverse effects can be increased when Zonisamide is combined with Felbamate.
Insulin Detemir (rDNA Origin) Injection	Insulin Detemir (rDNA Origin) Injection The therapeutic efficacy of Insulin detemir can be increased when used in combination with Zonisamide.
Ranolazine	Ranolazine The serum concentration of Ranolazine can be increased when it is combined with Zonisamide.
Abatacept Injection	Abatacept Injection The metabolism of Zonisamide can be increased when combined with Abatacept.
Rasagiline	Rasagiline Zonisamide may increase the excretion rate of Rasagiline which could result in a lower serum level and potentially a reduction in efficacy.
Imatinib	Imatinib The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Imatinib.
Sitagliptin	Sitagliptin The therapeutic efficacy of Sitagliptin can be increased when used in combination with Zonisamide.
Varenicline	Varenicline Zonisamide may increase the excretion rate of Varenicline which could result in a lower serum level and potentially a reduction in efficacy.
Gefitinib	Gefitinib The metabolism of Zonisamide can be decreased when combined with Gefitinib.
Albuterol	Albuterol Zonisamide may increase the excretion rate of Salbutamol which could result in a lower serum level and potentially a reduction in efficacy.
Paliperidone	Paliperidone The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Paliperidone.
Bortezomib	Bortezomib The serum concentration of Zonisamide can be increased when it is combined with Bortezomib.
Clofarabine Injection	Clofarabine Injection Clofarabine may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Insulin Glulisine (rDNA origin) Injection	Insulin Glulisine (rDNA origin) Injection The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Zonisamide.
Lubiprostone	Lubiprostone Zonisamide may increase the excretion rate of Lubiprostone which could result in a lower serum level and potentially a reduction in efficacy.
Oxaliplatin Injection	Oxaliplatin Injection The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Oxaliplatin.
Posaconazole	Posaconazole The serum concentration of Posaconazole can be increased when it is combined with Zonisamide.
Primaquine	Primaquine The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Primaquine.
Aliskiren	Aliskiren The risk or severity of hyperkalemia can be increased when Zonisamide is combined with Aliskiren.
Bismuth Subsalicylate	Bismuth Subsalicylate The risk or severity of adverse effects can be increased when Bismuth subsalicylate is combined with Zonisamide.
Darunavir	Darunavir The serum concentration of Zonisamide can be increased when it is combined with Darunavir.
Pemetrexed Injection	Pemetrexed Injection Zonisamide may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dimenhydrinate	Dimenhydrinate The risk or severity of adverse effects can be increased when Zonisamide is combined with Dimenhydrinate.
Lisdexamfetamine	Lisdexamfetamine Zonisamide may decrease the excretion rate of Lisdexamfetamine which could result in a higher serum level.
Nabilone	Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Zonisamide.
Vorinostat	Vorinostat The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Vorinostat.
Sorafenib	Sorafenib The metabolism of Zonisamide can be decreased when combined with Sorafenib.
Sunitinib	Sunitinib The metabolism of Sunitinib can be decreased when combined with Zonisamide.
Dronabinol	Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Zonisamide.
Lapatinib	Lapatinib The metabolism of Lapatinib can be decreased when combined with Zonisamide.
Levocetirizine	Levocetirizine The risk or severity of adverse effects can be increased when Zonisamide is combined with Levocetirizine.
Pegaptanib Injection	Pegaptanib Injection Zonisamide may increase the excretion rate of Pegaptanib which could result in a lower serum level and potentially a reduction in efficacy.
Dasatinib	Dasatinib The serum concentration of Dasatinib can be increased when it is combined with Zonisamide.
Mexiletine	Mexiletine Mexiletine may increase the arrhythmogenic activities of Zonisamide.
Armodafinil	Armodafinil The metabolism of Zonisamide can be decreased when combined with Armodafinil.
Azacitidine Injection	Azacitidine Injection Zonisamide may increase the excretion rate of Azacitidine which could result in a lower serum level and potentially a reduction in efficacy.
Paclitaxel (with polyoxyethylated castor oil) Injection	Paclitaxel (with polyoxyethylated castor oil) Injection The risk or severity of adverse effects can be increased when Zonisamide is combined with Castor oil.
Temsirolimus	Temsirolimus The serum concentration of Temsirolimus can be increased when it is combined with Zonisamide.
Lenalidomide	Lenalidomide Lenalidomide may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Nilotinib	Nilotinib The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Nilotinib.
Toremifene	Toremifene The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Toremifene.
Budesonide	Budesonide The metabolism of Budesonide can be increased when combined with Zonisamide.
Chloramphenicol Injection	Chloramphenicol Injection The metabolism of Zonisamide can be decreased when combined with Chloramphenicol.
Desmopressin	Desmopressin Desmopressin may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
OnabotulinumtoxinA Injection	OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Zonisamide.
RimabotulinumtoxinB Injection	RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Botulinum Toxin Type B is combined with Zonisamide.
Doripenem Injection	Doripenem Injection Zonisamide may increase the excretion rate of Doripenem which could result in a lower serum level and potentially a reduction in efficacy.
Etravirine	Etravirine The metabolism of Zonisamide can be decreased when combined with Etravirine.
Arsenic Trioxide Injection	Arsenic Trioxide Injection The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Arsenic trioxide.
Desvenlafaxine	Desvenlafaxine The risk or severity of adverse effects can be increased when Zonisamide is combined with Desvenlafaxine.
Cevimeline	Cevimeline Cevimeline may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Nebivolol	Nebivolol The risk or severity of bradycardia can be increased when Zonisamide is combined with Nebivolol.
Tretinoin	Tretinoin The metabolism of Zonisamide can be decreased when combined with Tretinoin.
Bendamustine Injection	Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Zonisamide.
Flecainide	Flecainide The excretion of Flecainide can be decreased when combined with Zonisamide.
Certolizumab Injection	Certolizumab Injection The metabolism of Zonisamide can be increased when combined with Certolizumab pegol.
Irinotecan Injection	Irinotecan Injection The metabolism of Zonisamide can be decreased when combined with Irinotecan.
Daptomycin Injection	Daptomycin Injection Daptomycin may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Praziquantel	Praziquantel The metabolism of Praziquantel can be decreased when combined with Zonisamide.
Methylnaltrexone Injection	Methylnaltrexone Injection Zonisamide may increase the excretion rate of Methylnaltrexone which could result in a lower serum level and potentially a reduction in efficacy.
Rufinamide	Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Zonisamide.
Silodosin	Silodosin The serum concentration of Silodosin can be increased when it is combined with Zonisamide.
Midazolam	Midazolam Midazolam may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Naltrexone Injection	Naltrexone Injection The therapeutic efficacy of Zonisamide can be decreased when used in combination with Naltrexone.
Dexrazoxane Injection	Dexrazoxane Injection Dexrazoxane may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Eltrombopag	Eltrombopag The metabolism of Zonisamide can be decreased when combined with Eltrombopag.
Milnacipran	Milnacipran The risk or severity of adverse effects can be increased when Zonisamide is combined with Milnacipran.
Dexlansoprazole	Dexlansoprazole The metabolism of Dexlansoprazole can be decreased when combined with Zonisamide.
Plerixafor Injection	Plerixafor Injection Zonisamide may increase the excretion rate of Plerixafor which could result in a lower serum level and potentially a reduction in efficacy.
Sodium Phosphate	Sodium Phosphate Zonisamide may increase the nephrotoxic activities of Sodium phosphate, monobasic.
Fesoterodine	Fesoterodine Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine.
Degarelix Injection	Degarelix Injection The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Degarelix.
Betaxolol	Betaxolol The risk or severity of bradycardia can be increased when Zonisamide is combined with Betaxolol.
Iloperidone	Iloperidone The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Iloperidone.
Prasugrel	Prasugrel Zonisamide may increase the excretion rate of Prasugrel which could result in a lower serum level and potentially a reduction in efficacy.
Lacosamide	Lacosamide The risk or severity of adverse effects can be increased when Zonisamide is combined with Lacosamide.
Everolimus	Everolimus The serum concentration of Everolimus can be increased when it is combined with Zonisamide.
Tolvaptan (low blood sodium)	Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Zonisamide.
Dronedarone	Dronedarone Dronedarone may increase the arrhythmogenic activities of Zonisamide.
AbobotulinumtoxinA Injection	AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Zonisamide.
Pralatrexate Injection	Pralatrexate Injection Zonisamide may increase the excretion rate of Pralatrexate which could result in a lower serum level and potentially a reduction in efficacy.
Palonosetron Injection	Palonosetron Injection Palonosetron may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Saxagliptin	Saxagliptin The therapeutic efficacy of Saxagliptin can be increased when used in combination with Zonisamide.
Telavancin Injection	Telavancin Injection The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Telavancin.
Romidepsin Injection	Romidepsin Injection The serum concentration of Romidepsin can be increased when it is combined with Zonisamide.
Tapentadol	Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Zonisamide.
Topotecan	Topotecan The serum concentration of Topotecan can be increased when it is combined with Zonisamide.
Golimumab Injection	Golimumab Injection The metabolism of Zonisamide can be increased when combined with Golimumab.
Pazopanib	Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Zonisamide.
Asenapine	Asenapine The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Asenapine.
Vigabatrin	Vigabatrin The risk or severity of adverse effects can be increased when Zonisamide is combined with Vigabatrin.
Albendazole	Albendazole The metabolism of Albendazole can be decreased when combined with Zonisamide.
Ulipristal	Ulipristal The metabolism of Ulipristal can be increased when combined with Zonisamide.
Levonorgestrel	Levonorgestrel The metabolism of Zonisamide can be increased when combined with Levonorgestrel.
Oxymorphone	Oxymorphone The risk or severity of adverse effects can be increased when Zonisamide is combined with Oxymorphone.
Liraglutide Injection	Liraglutide Injection The therapeutic efficacy of Liraglutide can be increased when used in combination with Zonisamide.
Tocilizumab Injection	Tocilizumab Injection The metabolism of Zonisamide can be increased when combined with Tocilizumab.
Dalfampridine	Dalfampridine Zonisamide may increase the excretion rate of Dalfampridine which could result in a lower serum level and potentially a reduction in efficacy.
Fingolimod	Fingolimod Zonisamide may increase the bradycardic activities of Fingolimod.
Eribulin Injection	Eribulin Injection The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Eribulin.
IncobotulinumtoxinA Injection	IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Zonisamide.
Cabazitaxel Injection	Cabazitaxel Injection The serum concentration of Cabazitaxel can be increased when it is combined with Zonisamide.
Ceftaroline Injection	Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Lurasidone	Lurasidone The risk or severity of adverse effects can be increased when Zonisamide is combined with Lurasidone.
Acetaminophen Injection	Acetaminophen Injection Acetaminophen may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Vilazodone	Vilazodone The risk or severity of adverse effects can be increased when Zonisamide is combined with Vilazodone.
Ipilimumab Injection	Ipilimumab Injection Zonisamide may increase the excretion rate of Ipilimumab which could result in a lower serum level and potentially a reduction in efficacy.
Denileukin Diftitox Injection	Denileukin Diftitox Injection Aldesleukin may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Terbutaline Injection	Terbutaline Injection Terbutaline may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Azilsartan	Azilsartan The risk or severity of hyperkalemia can be increased when Zonisamide is combined with Azilsartan medoxomil.
Roflumilast	Roflumilast Zonisamide may increase the excretion rate of Roflumilast which could result in a lower serum level and potentially a reduction in efficacy.
Linagliptin	Linagliptin The serum concentration of Linagliptin can be increased when it is combined with Zonisamide.
Rilpivirine	Rilpivirine The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Rilpivirine.
Telaprevir	Telaprevir The metabolism of Zonisamide can be decreased when combined with Glecaprevir.
Potassium Iodide	Potassium Iodide Potassium Iodide may increase the hyperkalemic activities of Zonisamide.
Cyclophosphamide Injection	Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Zonisamide.
Abiraterone	Abiraterone The metabolism of Zonisamide can be decreased when combined with Abiraterone.
Triptorelin Injection	Triptorelin Injection The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Triptorelin.
Rivaroxaban	Rivaroxaban The serum concentration of Rivaroxaban can be increased when it is combined with Zonisamide.
Ticagrelor	Ticagrelor The serum concentration of Ticagrelor can be increased when it is combined with Zonisamide.
Brentuximab Vedotin Injection	Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Zonisamide.
Ruxolitinib	Ruxolitinib Ruxolitinib may increase the bradycardic activities of Zonisamide.
Vandetanib	Vandetanib The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Vandetanib.
Clobazam	Clobazam The serum concentration of Clobazam can be increased when it is combined with Zonisamide.
Vemurafenib	Vemurafenib The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Vemurafenib.
Vismodegib	Vismodegib The metabolism of Zonisamide can be decreased when combined with Vismodegib.
Ivacaftor	Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Zonisamide.
Deferiprone	Deferiprone Zonisamide may increase the excretion rate of Deferiprone which could result in a lower serum level and potentially a reduction in efficacy.
Axitinib	Axitinib The serum concentration of Axitinib can be increased when it is combined with Zonisamide.
Crizotinib	Crizotinib The serum concentration of Crizotinib can be increased when it is combined with Zonisamide.
Cabergoline	Cabergoline The serum concentration of Zonisamide can be increased when it is combined with Cabergoline.
Naloxone Injection	Naloxone Injection Zonisamide may increase the excretion rate of Naloxone which could result in a lower serum level and potentially a reduction in efficacy.
Ambrisentan	Ambrisentan The serum concentration of Ambrisentan can be increased when it is combined with Zonisamide.
Fondaparinux Injection	Fondaparinux Injection Fondaparinux may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Ezogabine	Ezogabine The risk or severity of adverse effects can be increased when Tiagabine is combined with Zonisamide.
Carfilzomib Injection	Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Zonisamide.
Enzalutamide	Enzalutamide The metabolism of Enzalutamide can be increased when combined with Zonisamide.
Mirabegron	Mirabegron The serum concentration of Mirabegron can be increased when it is combined with Zonisamide.
Regorafenib	Regorafenib The serum concentration of Zonisamide can be increased when it is combined with Regorafenib.
Bosutinib	Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Zonisamide.
Linaclotide	Linaclotide The risk or severity of adverse effects can be increased when Zonisamide is combined with Linaclotide.
Lorcaserin	Lorcaserin The therapeutic efficacy of Mecasermin can be increased when used in combination with Zonisamide.
Teduglutide Injection	Teduglutide Injection Zonisamide may increase the excretion rate of Teduglutide which could result in a lower serum level and potentially a reduction in efficacy.
Bedaquiline	Bedaquiline The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Bedaquiline.
Tofacitinib	Tofacitinib Zonisamide may increase the bradycardic activities of Tofacitinib.
Alogliptin	Alogliptin The therapeutic efficacy of Alogliptin can be increased when used in combination with Zonisamide.
Ponatinib	Ponatinib The metabolism of Ponatinib can be decreased when combined with Zonisamide.
Pomalidomide	Pomalidomide The serum concentration of Pomalidomide can be increased when it is combined with Zonisamide.
Ado-trastuzumab Emtansine Injection	Ado-trastuzumab Emtansine Injection The serum concentration of Trastuzumab emtansine can be increased when it is combined with Zonisamide.
Apixaban	Apixaban The serum concentration of Apixaban can be increased when it is combined with Zonisamide.
Canagliflozin	Canagliflozin The therapeutic efficacy of Canagliflozin can be increased when used in combination with Zonisamide.
Methazolamide	Methazolamide The risk or severity of adverse effects can be increased when Methazolamide is combined with Zonisamide.
Dabrafenib	Dabrafenib The serum concentration of Zonisamide can be decreased when it is combined with Dabrafenib.
Trametinib	Trametinib Zonisamide may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy.
Dolutegravir	Dolutegravir The serum concentration of Dolutegravir can be increased when it is combined with Zonisamide.
Afatinib	Afatinib The serum concentration of Afatinib can be increased when it is combined with Zonisamide.
Levomilnacipran	Levomilnacipran The risk or severity of adverse effects can be increased when Zonisamide is combined with Levomilnacipran.
Ertapenem Injection	Ertapenem Injection Ertapenem may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Vortioxetine	Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Zonisamide.
Perampanel	Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Zonisamide.
Ibrutinib	Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Zonisamide.
Ketorolac Injection	Ketorolac Injection Ketorolac may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Simeprevir	Simeprevir The serum concentration of Simeprevir can be increased when it is combined with Zonisamide.
Sofosbuvir	Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Zonisamide.
Dapagliflozin	Dapagliflozin The therapeutic efficacy of Dapagliflozin can be increased when used in combination with Zonisamide.
Apremilast	Apremilast The metabolism of Zonisamide can be increased when combined with Apremilast.
Droxidopa	Droxidopa The risk or severity of Cardiac Arrhythmia can be increased when Droxidopa is combined with Zonisamide.
Ceritinib	Ceritinib Zonisamide may increase the bradycardic activities of Ceritinib.
Siltuximab Injection	Siltuximab Injection The metabolism of Zonisamide can be increased when combined with Siltuximab.
Albiglutide Injection	Albiglutide Injection The therapeutic efficacy of Albiglutide can be increased when used in combination with Zonisamide.
Eslicarbazepine	Eslicarbazepine The risk or severity of adverse effects can be increased when Zonisamide is combined with Eslicarbazepine.
Belinostat Injection	Belinostat Injection The serum concentration of Belinostat can be increased when it is combined with Zonisamide.
Idelalisib	Idelalisib The serum concentration of Idelalisib can be increased when it is combined with Zonisamide.
Testosterone Injection	Testosterone Injection Testosterone may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Oritavancin Injection	Oritavancin Injection The metabolism of Zonisamide can be decreased when combined with Oritavancin.
Empagliflozin	Empagliflozin Zonisamide may increase the diuretic activities of Empagliflozin.
Hydrocodone	Hydrocodone Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Suvorexant	Suvorexant Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Dulaglutide Injection	Dulaglutide Injection The therapeutic efficacy of Dulaglutide can be increased when used in combination with Zonisamide.
Edoxaban	Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Zonisamide.
Olaparib	Olaparib The metabolism of Olaparib can be decreased when combined with Zonisamide.
Methamphetamine	Methamphetamine The risk or severity of adverse effects can be increased when Zonisamide is combined with Metamfetamine.
Tasimelteon	Tasimelteon The risk or severity of adverse effects can be increased when Zonisamide is combined with Tasimelteon.
Lanreotide Injection	Lanreotide Injection Zonisamide may increase the bradycardic activities of Lanreotide.
Nintedanib	Nintedanib The serum concentration of Nintedanib can be increased when it is combined with Zonisamide.
Secukinumab Injection	Secukinumab Injection The metabolism of Zonisamide can be increased when combined with Secukinumab.
Risperidone Injection	Risperidone Injection The risk or severity of adverse effects can be increased when Risperidone is combined with Zonisamide.
Insulin Human Inhalation	Insulin Human Inhalation The therapeutic efficacy of Insulin human can be increased when used in combination with Zonisamide.
Lenvatinib	Lenvatinib The serum concentration of Lenvatinib can be increased when it is combined with Zonisamide.
Naloxegol	Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Zonisamide.
Panobinostat	Panobinostat The serum concentration of Panobinostat can be increased when it is combined with Zonisamide.
Haloperidol Injection	Haloperidol Injection The risk or severity of QTc prolongation can be increased when Haloperidol is combined with Zonisamide.
Ivabradine	Ivabradine Zonisamide may increase the bradycardic activities of Ivabradine.
Amiloride	Amiloride Amiloride may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Isavuconazonium Injection	Isavuconazonium Injection The therapeutic efficacy of Isavuconazonium can be increased when used in combination with Zonisamide.
Macitentan	Macitentan Zonisamide may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy.
Flibanserin	Flibanserin The risk or severity of adverse effects can be increased when Zonisamide is combined with Flibanserin.
Daclatasvir	Daclatasvir The metabolism of Daclatasvir can be decreased when combined with Zonisamide.
Brexpiprazole	Brexpiprazole The risk or severity of adverse effects can be increased when Zonisamide is combined with Brexpiprazole.
Ziprasidone Injection	Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Ziprasidone.
Cariprazine	Cariprazine The risk or severity of adverse effects can be increased when Zonisamide is combined with Cariprazine.
Penicillin G Procaine Injection	Penicillin G Procaine Injection Zonisamide may increase the excretion rate of Procaine benzylpenicillin which could result in a lower serum level and potentially a reduction in efficacy.
Eluxadoline	Eluxadoline The therapeutic efficacy of Zonisamide can be decreased when used in combination with Eluxadoline.
Insulin Degludec (rDNA Origin) Injection	Insulin Degludec (rDNA Origin) Injection The therapeutic efficacy of Insulin degludec can be increased when used in combination with Zonisamide.
Cobimetinib	Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Zonisamide.
Trabectedin Injection	Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Zonisamide.
Osimertinib	Osimertinib The serum concentration of Osimertinib can be increased when it is combined with Zonisamide.
Ixazomib	Ixazomib Zonisamide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Rifapentine	Rifapentine The metabolism of Zonisamide can be increased when combined with Rifapentine.
Lesinurad	Lesinurad Zonisamide may increase the excretion rate of Lesinurad which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Liposomal Injection	Amphotericin B Liposomal Injection Zonisamide may decrease the nephrotoxic activities of Amphotericin B.
Dexamethasone Injection	Dexamethasone Injection The metabolism of Zonisamide can be increased when combined with Dexamethasone.
Brivaracetam Injection	Brivaracetam Injection The risk or severity of adverse effects can be increased when Zonisamide is combined with Brivaracetam.
Venetoclax	Venetoclax The serum concentration of Venetoclax can be increased when it is combined with Zonisamide.
Cobicistat	Cobicistat The metabolism of Zonisamide can be decreased when combined with Cobicistat.
Midodrine	Midodrine Midodrine may increase the bradycardic activities of Zonisamide.
Selexipag	Selexipag The serum concentration of Selexipag can be increased when it is combined with Zonisamide.
Pimavanserin	Pimavanserin The risk or severity of adverse effects can be increased when Zonisamide is combined with Pimavanserin.
Diphenhydramine Injection	Diphenhydramine Injection The risk or severity of adverse effects can be increased when Zonisamide is combined with Diphenhydramine.
Furosemide Injection	Furosemide Injection Furosemide may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Rucaparib	Rucaparib The metabolism of Zonisamide can be decreased when combined with Rucaparib.
Lixisenatide Injection	Lixisenatide Injection The therapeutic efficacy of Lixisenatide can be increased when used in combination with Zonisamide.
Ribociclib	Ribociclib The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Ribociclib.
Doxepin (Insomnia)	Doxepin (Insomnia) Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Plecanatide	Plecanatide The risk or severity of adverse effects can be increased when Zonisamide is combined with Plecanatide.
Deutetrabenazine	Deutetrabenazine The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Deutetrabenazine.
Valbenazine	Valbenazine Zonisamide may increase the excretion rate of Valbenazine which could result in a lower serum level and potentially a reduction in efficacy.
Deflazacort	Deflazacort The metabolism of Zonisamide can be increased when combined with Deflazacort.
Safinamide	Safinamide The risk or severity of adverse effects can be increased when Zonisamide is combined with Safinamide.
Naldemedine	Naldemedine Zonisamide may increase the excretion rate of Naldemedine which could result in a lower serum level and potentially a reduction in efficacy.
Midostaurin	Midostaurin The metabolism of Zonisamide can be increased when combined with Midostaurin.
Enasidenib	Enasidenib The metabolism of Zonisamide can be decreased when combined with Enasidenib.
Inotuzumab Ozogamicin Injection	Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Zonisamide.
Benznidazole	Benznidazole Zonisamide may increase the excretion rate of Benznidazole which could result in a lower serum level and potentially a reduction in efficacy.
Copanlisib Injection	Copanlisib Injection The serum concentration of Copanlisib can be increased when it is combined with Zonisamide.
Delafloxacin	Delafloxacin Zonisamide may increase the excretion rate of Delafloxacin which could result in a lower serum level and potentially a reduction in efficacy.
Abemaciclib	Abemaciclib The serum concentration of Abemaciclib can be increased when it is combined with Zonisamide.
Betrixaban	Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Zonisamide.
Acalabrutinib	Acalabrutinib The metabolism of Zonisamide can be decreased when combined with Acalabrutinib.
Letermovir	Letermovir The metabolism of Zonisamide can be decreased when combined with Letermovir.
Semaglutide Injection	Semaglutide Injection The therapeutic efficacy of Semaglutide can be increased when used in combination with Zonisamide.
Tetrabenazine	Tetrabenazine The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Tetrabenazine.
Ertugliflozin	Ertugliflozin The metabolism of Zonisamide can be decreased when combined with Ertugliflozin.
Buprenorphine Injection	Buprenorphine Injection Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Apalutamide	Apalutamide The serum concentration of Zonisamide can be increased when it is combined with Apalutamide.
Fostamatinib	Fostamatinib The metabolism of Zonisamide can be decreased when combined with Fostamatinib.
Avatrombopag	Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Zonisamide.
Baricitinib	Baricitinib The serum concentration of Baricitinib can be increased when it is combined with Zonisamide.
Lofexidine	Lofexidine The therapeutic efficacy of Zonisamide can be increased when used in combination with Lofexidine.
Plazomicin Injection	Plazomicin Injection Zonisamide may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Eliglustat	Eliglustat The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Eliglustat.
Encorafenib	Encorafenib The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Encorafenib.
Binimetinib	Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Zonisamide.
Ivosidenib	Ivosidenib The serum concentration of Ivosidenib can be increased when it is combined with Zonisamide.
Lusutrombopag	Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Zonisamide.
Elagolix	Elagolix The serum concentration of Elagolix can be increased when it is combined with Zonisamide.
Eravacycline Injection	Eravacycline Injection The metabolism of Eravacycline can be decreased when combined with Zonisamide.
Doravirine	Doravirine The metabolism of Doravirine can be decreased when combined with Zonisamide.
Cannabidiol	Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Zonisamide.
Dacomitinib	Dacomitinib The serum concentration of Zonisamide can be increased when it is combined with Dacomitinib.
Duvelisib	Duvelisib The serum concentration of Duvelisib can be increased when it is combined with Zonisamide.
Omadacycline	Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Zonisamide.
Stiripentol	Stiripentol The metabolism of Zonisamide can be decreased when combined with Stiripentol.
Talazoparib	Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Zonisamide.
Gilteritinib	Gilteritinib The serum concentration of Gilteritinib can be increased when it is combined with Zonisamide.
Glasdegib	Glasdegib The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Glasdegib.
Lorlatinib	Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Zonisamide.
Larotrectinib	Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Zonisamide.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Zonisamide.
Rifamycin	Rifamycin The metabolism of Rifamycin can be increased when combined with Zonisamide.
Prucalopride	Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Zonisamide.
Magnesium Citrate	Magnesium Citrate The risk or severity of hypotension can be increased when Zonisamide is combined with Magnesium citrate.
Emapalumab-lzsg Injection	Emapalumab-lzsg Injection The metabolism of Zonisamide can be increased when combined with Emapalumab.
Acyclovir Ophthalmic	Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Esomeprazole Injection	Esomeprazole Injection The metabolism of Zonisamide can be decreased when combined with Esomeprazole.
Alpelisib	Alpelisib The metabolism of Zonisamide can be decreased when combined with Alpelisib.
Brexanolone Injection	Brexanolone Injection The risk or severity of adverse effects can be increased when Zonisamide is combined with Brexanolone.
Solriamfetol	Solriamfetol The risk or severity of adverse effects can be increased when Zonisamide is combined with Solriamfetol.
Darolutamide	Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Zonisamide.
Triclabendazole	Triclabendazole The metabolism of Zonisamide can be decreased when combined with Triclabendazole.
Entrectinib	Entrectinib The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Entrectinib.
Pexidartinib	Pexidartinib The metabolism of Zonisamide can be decreased when combined with Pexidartinib.
Istradefylline	Istradefylline The metabolism of Istradefylline can be decreased when combined with Zonisamide.
Pitolisant	Pitolisant The serum concentration of Zonisamide can be decreased when it is combined with Pitolisant.
Fedratinib	Fedratinib The serum concentration of Fedratinib can be increased when it is combined with Zonisamide.
Lefamulin	Lefamulin Zonisamide may increase the QTc-prolonging activities of Lefamulin.
Phenytoin Injection	Phenytoin Injection Phenytoin may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Fosphenytoin Injection	Fosphenytoin Injection Fosphenytoin may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Enfortumab vedotin-ejfv Injection	Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Zonisamide.
Voxelotor	Voxelotor The metabolism of Voxelotor can be decreased when combined with Zonisamide.
Lumateperone	Lumateperone The risk or severity of adverse effects can be increased when Zonisamide is combined with Lumateperone.
Lasmiditan	Lasmiditan The risk or severity of adverse effects can be increased when Zonisamide is combined with Lasmiditan.
Ubrogepant	Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Zonisamide.
Calcium Acetate	Calcium Acetate The therapeutic efficacy of Zonisamide can be decreased when used in combination with Calcium acetate.
Tazemetostat	Tazemetostat The serum concentration of Tazemetostat can be increased when it is combined with Zonisamide.
Cenobamate	Cenobamate The serum concentration of Zonisamide can be decreased when it is combined with Cenobamate.
Selumetinib	Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Zonisamide.
Rimegepant	Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Zonisamide.
Tucatinib	Tucatinib The metabolism of Tucatinib can be decreased when combined with Zonisamide.
Remdesivir Injection	Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Zonisamide.
Ripretinib	Ripretinib The serum concentration of Ripretinib can be increased when it is combined with Zonisamide.
Lemborexant	Lemborexant The risk or severity of adverse effects can be increased when Zonisamide is combined with Lemborexant.
Fenfluramine	Fenfluramine The risk or severity of adverse effects can be increased when Fenfluramine is combined with Zonisamide.
Fostemsavir	Fostemsavir The serum concentration of Fostemsavir can be increased when it is combined with Zonisamide.
Octreotide	Octreotide The serum concentration of the active metabolites of Zonisamide can be increased when Zonisamide is used in combination with Octreotide.
Belantamab Mafodotin-blmf Injection	Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Zonisamide.
Pralsetinib	Pralsetinib The serum concentration of Pralsetinib can be increased when it is combined with Zonisamide.
Satralizumab-mwge Injection	Satralizumab-mwge Injection The serum concentration of Zonisamide can be decreased when it is combined with Satralizumab.
Relugolix	Relugolix The serum concentration of Relugolix can be increased when it is combined with Zonisamide.
Progestin-Only (drospirenone) Oral Contraceptives	Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be increased when combined with Zonisamide.
Viloxazine	Viloxazine Zonisamide may increase the excretion rate of Viloxazine which could result in a lower serum level and potentially a reduction in efficacy.
Tobramycin Injection	Tobramycin Injection Tobramycin may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Theophylline	Theophylline Zonisamide may increase the excretion rate of Theophylline which could result in a lower serum level and potentially a reduction in efficacy.
Fenoprofen	Fenoprofen Fenoprofen may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Indomethacin	Indomethacin The metabolism of Zonisamide can be decreased when combined with Indomethacin.
Mefenamic Acid	Mefenamic Acid Mefenamic acid may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Naproxen	Naproxen Naproxen may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Tolmetin	Tolmetin Tolmetin may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Sulindac	Sulindac Sulindac may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Trazodone	Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Zonisamide.
Isotretinoin	Isotretinoin Zonisamide may increase the excretion rate of Isotretinoin which could result in a lower serum level and potentially a reduction in efficacy.
Sucralfate	Sucralfate Sucralfate may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Floxuridine	Floxuridine Floxuridine may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Phenobarbital	Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Zonisamide.
Metaxalone	Metaxalone The risk or severity of adverse effects can be increased when Metaxalone is combined with Zonisamide.
Methotrexate Injection	Methotrexate Injection The risk or severity of adverse effects can be increased when Zonisamide is combined with Methotrexate.
Levorphanol	Levorphanol The risk or severity of adverse effects can be increased when Levorphanol is combined with Zonisamide.
Primidone	Primidone The metabolism of Primidone can be decreased when combined with Zonisamide.
Methsuximide	Methsuximide Zonisamide may increase the arrhythmogenic activities of Methsuximide.
Diethylpropion	Diethylpropion The risk or severity of adverse effects can be increased when Zonisamide is combined with Diethylpropion.
Chlorpromazine	Chlorpromazine The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Chlorpromazine.
Diazepam	Diazepam The risk or severity of adverse effects can be increased when Diazepam is combined with Zonisamide.
Oxazepam	Oxazepam The risk or severity of adverse effects can be increased when Oxazepam is combined with Zonisamide.
Flurazepam	Flurazepam The risk or severity of adverse effects can be increased when Flurazepam is combined with Zonisamide.
Clorazepate	Clorazepate The risk or severity of adverse effects can be increased when Clorazepic acid is combined with Zonisamide.
Lorazepam	Lorazepam The risk or severity of adverse effects can be increased when Lorazepam is combined with Zonisamide.
Phenoxybenzamine	Phenoxybenzamine The risk or severity of hypotension can be increased when Phenoxybenzamine is combined with Zonisamide.
Carmustine	Carmustine Carmustine may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Amantadine	Amantadine Zonisamide may increase the excretion rate of Amantadine which could result in a lower serum level and potentially a reduction in efficacy.
Codeine	Codeine The risk or severity of adverse effects can be increased when Codeine is combined with Zonisamide.
Meprobamate	Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Zonisamide.
Chlordiazepoxide	Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Zonisamide.
Bromocriptine	Bromocriptine The risk or severity of adverse effects can be increased when Zonisamide is combined with Bromocriptine.
Tranylcypromine	Tranylcypromine The metabolism of Zonisamide can be decreased when combined with Tranylcypromine.
Phenelzine	Phenelzine The metabolism of Phenelzine can be decreased when combined with Zonisamide.
Procarbazine	Procarbazine The risk or severity of adverse effects can be increased when Zonisamide is combined with Procarbazine.
Ergoloid Mesylates	Ergoloid Mesylates The risk or severity of adverse effects can be increased when Zonisamide is combined with Ergoloid mesylate.
Tetracycline	Tetracycline Tetracycline may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Minocycline	Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Zonisamide.
Prochlorperazine	Prochlorperazine The risk or severity of adverse effects can be increased when Prochlorperazine is combined with Zonisamide.
Thioridazine	Thioridazine The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Thioridazine.
Trifluoperazine	Trifluoperazine The risk or severity of adverse effects can be increased when Trifluoperazine is combined with Zonisamide.
Bleomycin	Bleomycin Bleomycin may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Dapsone	Dapsone The metabolism of Zonisamide can be decreased when combined with Dapsone.
Sulfadiazine	Sulfadiazine The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Zonisamide.
Oxycodone	Oxycodone The risk or severity of adverse effects can be increased when Oxycodone is combined with Zonisamide.
Methadone	Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Zonisamide.
Oxybutynin	Oxybutynin Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Oxybutynin.
Benztropine	Benztropine Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Benzatropine.
Colestipol	Colestipol Colestipol can cause a decrease in the absorption of Zonisamide resulting in a reduced serum concentration and potentially a decrease in efficacy.
Maprotiline	Maprotiline Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Maprotiline.
Ibuprofen	Ibuprofen Ibuprofen may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Trihexyphenidyl	Trihexyphenidyl Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine	Orphenadrine Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Perphenazine	Perphenazine The risk or severity of adverse effects can be increased when Perphenazine is combined with Zonisamide.
Azathioprine	Azathioprine Zonisamide may increase the excretion rate of Azathioprine which could result in a lower serum level and potentially a reduction in efficacy.
Fluphenazine	Fluphenazine The risk or severity of adverse effects can be increased when Fluphenazine is combined with Zonisamide.
Phentermine	Phentermine Zonisamide may decrease the excretion rate of Phentermine which could result in a higher serum level.
Methylphenidate	Methylphenidate Methylphenidate may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Amoxapine	Amoxapine Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Amoxapine.
Sulfasalazine	Sulfasalazine The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Zonisamide.
Hydrocortisone	Hydrocortisone The metabolism of Zonisamide can be decreased when combined with Hydrocortisone.
Doxorubicin	Doxorubicin The serum concentration of Doxorubicin can be increased when it is combined with Zonisamide.
Dactinomycin	Dactinomycin The serum concentration of Dactinomycin can be increased when it is combined with Zonisamide.
Phenazopyridine	Phenazopyridine Phenazopyridine may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Carbamazepine	Carbamazepine Carbamazepine may increase the Change in thyroid function activities of Zonisamide.
Molindone	Molindone The risk or severity of adverse effects can be increased when Zonisamide is combined with Molindone.
Methyldopa	Methyldopa Zonisamide may increase the excretion rate of Methyldopa which could result in a lower serum level and potentially a reduction in efficacy.
Clonidine	Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Zonisamide.
Prazosin	Prazosin The risk or severity of hypotension can be increased when Prazosin is combined with Zonisamide.
Hydralazine	Hydralazine Zonisamide may increase the excretion rate of Hydralazine which could result in a lower serum level and potentially a reduction in efficacy.
Cimetidine	Cimetidine The serum concentration of Zonisamide can be increased when it is combined with Cimetidine.
Gentamicin Injection	Gentamicin Injection Gentamicin may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Warfarin	Warfarin Warfarin may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Clonazepam	Clonazepam The risk or severity of adverse effects can be increased when Zonisamide is combined with Clonazepam.
Loperamide	Loperamide Zonisamide may increase the arrhythmogenic activities of Loperamide.
Promethazine	Promethazine The risk or severity of adverse effects can be increased when Zonisamide is combined with Promethazine.
Meclofenamate	Meclofenamate Meclofenamic acid may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Daunorubicin	Daunorubicin The metabolism of Zonisamide can be increased when combined with Daunorubicin.
Nitrofurantoin	Nitrofurantoin Nitrofurantoin may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Methenamine	Methenamine The serum concentration of the active metabolites of Methenamine can be reduced when Methenamine is used in combination with Zonisamide resulting in a loss in efficacy.
Digoxin	Digoxin Zonisamide may increase the arrhythmogenic activities of Digoxin.
Loxapine	Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Zonisamide.
Chloroquine	Chloroquine The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Chloroquine.
Quinine	Quinine The excretion of Quinine can be decreased when combined with Zonisamide.
Ethosuximide	Ethosuximide Ethosuximide may increase the arrhythmogenic activities of Zonisamide.
Triamterene	Triamterene Triamterene may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Lactulose	Lactulose The risk or severity of adverse effects can be increased when Zonisamide is combined with Lactulose.
Chlorothiazide	Chlorothiazide Chlorothiazide may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Chlorthalidone	Chlorthalidone Chlorthalidone may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone	Metolazone Metolazone may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide	Isosorbide The metabolism of Zonisamide can be increased when combined with Isosorbide.
Clindamycin Injection	Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Zonisamide.
Secobarbital	Secobarbital The risk or severity of adverse effects can be increased when Secobarbital is combined with Zonisamide.
Desipramine	Desipramine Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Amitriptyline	Amitriptyline Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Imipramine	Imipramine The serum concentration of Imipramine can be increased when it is combined with Zonisamide.
Probenecid	Probenecid The metabolism of Zonisamide can be decreased when combined with Probenecid.
Quinidine	Quinidine Zonisamide may increase the arrhythmogenic activities of Quinidine.
Procainamide	Procainamide Zonisamide may increase the arrhythmogenic activities of Procainamide.
Isoniazid	Isoniazid The metabolism of Zonisamide can be decreased when combined with Isoniazid.
Pyrazinamide	Pyrazinamide Pyrazinamide may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Rifampin	Rifampin The metabolism of Zonisamide can be increased when combined with Rifampicin.
Disopyramide	Disopyramide Zonisamide may increase the arrhythmogenic activities of Disopyramide.
Valproic Acid	Valproic Acid The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Valproic acid.
Tamoxifen	Tamoxifen The metabolism of Zonisamide can be decreased when combined with Tamoxifen.
Butabarbital	Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Zonisamide.
Liothyronine	Liothyronine Liothyronine may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Methimazole	Methimazole The metabolism of Zonisamide can be decreased when combined with Methimazole.
Chlorpropamide	Chlorpropamide The therapeutic efficacy of Chlorpropamide can be increased when used in combination with Zonisamide.
Tolbutamide	Tolbutamide The therapeutic efficacy of Tolbutamide can be increased when used in combination with Zonisamide.
Tolazamide	Tolazamide The therapeutic efficacy of Tolazamide can be increased when used in combination with Zonisamide.
Dextromethorphan	Dextromethorphan The risk or severity of adverse effects can be increased when Dextromethorphan is combined with Zonisamide.
Cyclobenzaprine	Cyclobenzaprine The risk or severity of CNS depression can be increased when Zonisamide is combined with Cyclobenzaprine.
Baclofen	Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Zonisamide.
Doxylamine	Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Zonisamide.
Cyproheptadine	Cyproheptadine Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.
Clemastine	Clemastine The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Clemastine.
Chlorpheniramine	Chlorpheniramine The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Chlorpheniramine.
Brompheniramine	Brompheniramine The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Zonisamide.
Meclizine	Meclizine The risk or severity of adverse effects can be increased when Meclizine is combined with Zonisamide.
Ethambutol	Ethambutol Ethambutol may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Methyclothiazide	Methyclothiazide Methyclothiazide may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Hydrochlorothiazide	Hydrochlorothiazide Hydrochlorothiazide may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Dantrolene	Dantrolene The risk or severity of hyperkalemia can be increased when Dantrolene is combined with Zonisamide.
Chlorzoxazone	Chlorzoxazone The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Zonisamide.
Carisoprodol	Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Zonisamide.
Methocarbamol	Methocarbamol The risk or severity of adverse effects can be increased when Methocarbamol is combined with Zonisamide.
Pyridoxine	Pyridoxine Pyridoxine may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Folic Acid	Folic Acid Folic acid may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Disulfiram	Disulfiram The therapeutic efficacy of Zonisamide can be decreased when used in combination with Disulfiram.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) The serum concentration of Propranolol can be increased when it is combined with Zonisamide.
Pseudoephedrine	Pseudoephedrine Zonisamide may decrease the excretion rate of Pseudoephedrine which could result in a higher serum level.
Nortriptyline	Nortriptyline The serum concentration of Nortriptyline can be increased when it is combined with Zonisamide.
Spironolactone	Spironolactone Spironolactone may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection	Amphotericin B Injection Zonisamide may decrease the nephrotoxic activities of Amphotericin B.
Mercaptopurine	Mercaptopurine Zonisamide may increase the excretion rate of Mercaptopurine which could result in a lower serum level and potentially a reduction in efficacy.
Phytonadione	Phytonadione Zonisamide may increase the excretion rate of Phylloquinone which could result in a lower serum level and potentially a reduction in efficacy.
Amikacin Injection	Amikacin Injection Amikacin may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Nadolol	Nadolol The risk or severity of bradycardia can be increased when Zonisamide is combined with Nadolol.
Butorphanol Injection	Butorphanol Injection The risk or severity of adverse effects can be increased when Butorphanol is combined with Zonisamide.
Nalbuphine Injection	Nalbuphine Injection The risk or severity of adverse effects can be increased when Nalbuphine is combined with Zonisamide.
Cholestyramine Resin	Cholestyramine Resin Cholestyramine can cause a decrease in the absorption of Zonisamide resulting in a reduced serum concentration and potentially a decrease in efficacy.
Allopurinol	Allopurinol Allopurinol may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Oxytocin Injection	Oxytocin Injection The risk or severity of QTc prolongation can be increased when Oxytocin is combined with Zonisamide.
Trimethobenzamide	Trimethobenzamide The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Zonisamide.
Clomiphene	Clomiphene The serum concentration of Clomifene can be increased when it is combined with Zonisamide.
Flavoxate	Flavoxate Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
Papaverine	Papaverine The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Papaverine.
Fluorouracil Injection	Fluorouracil Injection The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Fluorouracil.
Colchicine	Colchicine The serum concentration of Colchicine can be increased when it is combined with Zonisamide.
Cefaclor	Cefaclor Cefaclor may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Cefadroxil	Cefadroxil Cefadroxil may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Cefazolin Injection	Cefazolin Injection Cefazolin may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Cephalexin	Cephalexin Cephalexin may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Cefoxitin Injection	Cefoxitin Injection Cefoxitin may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Dacarbazine	Dacarbazine Dacarbazine may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Acetazolamide	Acetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Zonisamide.
Cefotaxime Injection	Cefotaxime Injection Cefotaxime may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Calcitonin Salmon Injection	Calcitonin Salmon Injection Salmon calcitonin may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Ketoconazole	Ketoconazole The metabolism of Zonisamide can be decreased when combined with Ketoconazole.
Pyrantel	Pyrantel The risk or severity of adverse effects can be increased when Zonisamide is combined with Pyrantel.
Vincristine Injection	Vincristine Injection The excretion of Vincristine can be decreased when combined with Zonisamide.
Captopril	Captopril The risk or severity of hyperkalemia can be increased when Zonisamide is combined with Captopril.
Vinblastine	Vinblastine The serum concentration of Vinblastine can be increased when it is combined with Zonisamide.
Ethacrynic Acid	Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Colistimethate Injection	Colistimethate Injection Colistimethate may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Metoprolol	Metoprolol The risk or severity of bradycardia can be increased when Zonisamide is combined with Metoprolol.
Hydroxyzine	Hydroxyzine The risk or severity of QTc prolongation can be increased when Hydroxyzine is combined with Zonisamide.
Thiothixene	Thiothixene The risk or severity of adverse effects can be increased when Zonisamide is combined with Thiothixene.
Aspirin	Aspirin Acetylsalicylic acid may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Salsalate	Salsalate Salsalate may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Chlorambucil	Chlorambucil The therapeutic efficacy of Zonisamide can be decreased when used in combination with Chlorambucil.
Alprazolam	Alprazolam Alprazolam may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Temazepam	Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Zonisamide.
Triazolam	Triazolam Triazolam may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Dicyclomine	Dicyclomine Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
Hyoscyamine	Hyoscyamine Zonisamide may increase the arrhythmogenic activities of Hyoscyamine.
Propantheline	Propantheline Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
Trimethoprim	Trimethoprim Trimethoprim may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Diltiazem	Diltiazem Zonisamide may increase the arrhythmogenic activities of Diltiazem.
Nifedipine	Nifedipine Zonisamide may increase the arrhythmogenic activities of Nifedipine.
Timolol	Timolol The risk or severity of adverse effects can be increased when Zonisamide is combined with Timolol.
Verapamil	Verapamil Zonisamide may increase the arrhythmogenic activities of Verapamil.
Atenolol	Atenolol The risk or severity of bradycardia can be increased when Zonisamide is combined with Atenolol.
Pindolol	Pindolol The risk or severity of bradycardia can be increased when Zonisamide is combined with Pindolol.
Cisplatin Injection	Cisplatin Injection Zonisamide may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal	Diflunisal The risk or severity of adverse effects can be increased when Diflunisal is combined with Zonisamide.
Piroxicam	Piroxicam Piroxicam may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Bumetanide	Bumetanide Bumetanide may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Etoposide	Etoposide The serum concentration of Etoposide can be increased when it is combined with Zonisamide.
Glyburide	Glyburide The therapeutic efficacy of Glyburide can be increased when used in combination with Zonisamide.
Glipizide	Glipizide The therapeutic efficacy of Glipizide can be increased when used in combination with Zonisamide.
Indapamide	Indapamide Indapamide may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin	Amoxicillin Zonisamide may increase the excretion rate of Amoxicillin which could result in a lower serum level and potentially a reduction in efficacy.
Nafcillin Injection	Nafcillin Injection The therapeutic efficacy of Zonisamide can be decreased when used in combination with Nafcillin.
Oxacillin Injection	Oxacillin Injection Oxacillin may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Pentoxifylline	Pentoxifylline Zonisamide may increase the excretion rate of Pentoxifylline which could result in a lower serum level and potentially a reduction in efficacy.
Pentamidine Injection	Pentamidine Injection The therapeutic efficacy of Pentamidine can be increased when used in combination with Zonisamide.
Ceftriaxone Injection	Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Labetalol	Labetalol The risk or severity of bradycardia can be increased when Labetalol is combined with Zonisamide.
Auranofin	Auranofin Zonisamide may increase the excretion rate of Auranofin which could result in a lower serum level and potentially a reduction in efficacy.
Leuprolide Injection	Leuprolide Injection The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Leuprolide.
Gemfibrozil	Gemfibrozil The metabolism of Zonisamide can be decreased when combined with Gemfibrozil.
Dipivefrin Ophthalmic	Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Ceftazidime Injection	Ceftazidime Injection Ceftazidime may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Ketoprofen	Ketoprofen The risk or severity of adverse effects can be increased when Ketoprofen is combined with Zonisamide.
Cefotetan Injection	Cefotetan Injection Cefotetan may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Pimozide	Pimozide The metabolism of Pimozide can be decreased when combined with Zonisamide.
Enalapril	Enalapril The risk or severity of hyperkalemia can be increased when Enalapril is combined with Zonisamide.
Flurbiprofen	Flurbiprofen The metabolism of Zonisamide can be decreased when combined with Flurbiprofen.
Amiodarone	Amiodarone The risk or severity of adverse effects can be increased when Zonisamide is combined with Amiodarone.
Aztreonam Injection	Aztreonam Injection Aztreonam may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Buspirone	Buspirone Buspirone may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Lovastatin	Lovastatin The metabolism of Zonisamide can be decreased when combined with Lovastatin.
Ciprofloxacin	Ciprofloxacin The metabolism of Zonisamide can be decreased when combined with Ciprofloxacin.
Mesalamine	Mesalamine The risk or severity of adverse effects can be increased when Mesalazine is combined with Zonisamide.
Diclofenac	Diclofenac Diclofenac may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Fluoxetine	Fluoxetine Fluoxetine may increase the central nervous system depressant (CNS depressant) activities of Zonisamide.
Nimodipine	Nimodipine Zonisamide may increase the arrhythmogenic activities of Nimodipine.
Clozapine	Clozapine The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Clozapine.
Estazolam	Estazolam The risk or severity of adverse effects can be increased when Zonisamide is combined with Estazolam.
Ofloxacin	Ofloxacin The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Ofloxacin.
Didanosine	Didanosine Didanosine may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Pentostatin Injection	Pentostatin Injection Pentostatin may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Clarithromycin	Clarithromycin The metabolism of Zonisamide can be decreased when combined with Clarithromycin.
Benazepril	Benazepril The risk or severity of hyperkalemia can be increased when Benazepril is combined with Zonisamide.
Etodolac	Etodolac Etodolac may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Felodipine	Felodipine Zonisamide may increase the arrhythmogenic activities of Felodipine.
Fosinopril	Fosinopril Fosinopril may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Nabumetone	Nabumetone Nabumetone may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Pravastatin	Pravastatin The serum concentration of Pravastatin can be increased when it is combined with Zonisamide.
Quinapril	Quinapril The risk or severity of hyperkalemia can be increased when Quinapril is combined with Zonisamide.
Ramipril	Ramipril The risk or severity of hyperkalemia can be increased when Ramipril is combined with Zonisamide.
Simvastatin	Simvastatin The serum concentration of Simvastatin can be increased when it is combined with Zonisamide.
Amlodipine	Amlodipine Amlodipine may increase the arrhythmogenic activities of Zonisamide.
Teniposide Injection	Teniposide Injection The metabolism of Zonisamide can be decreased when combined with Teniposide.
Itraconazole	Itraconazole The metabolism of Zonisamide can be decreased when combined with Itraconazole.
Lisinopril	Lisinopril Lisinopril may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Oxaprozin	Oxaprozin Oxaprozin may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Rifabutin	Rifabutin The metabolism of Zonisamide can be increased when combined with Rifabutin.
Sotalol	Sotalol The risk or severity of bradycardia can be increased when Zonisamide is combined with Sotalol.
Bisoprolol	Bisoprolol The therapeutic efficacy of Zonisamide can be increased when used in combination with Bisoprolol.
Zolpidem	Zolpidem Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin	Doxazosin The risk or severity of hypotension can be increased when Doxazosin is combined with Zonisamide.
Terazosin	Terazosin The risk or severity of hypotension can be increased when Terazosin is combined with Zonisamide.
Isradipine	Isradipine Isradipine may increase the arrhythmogenic activities of Zonisamide.
Omeprazole	Omeprazole The metabolism of Zonisamide can be decreased when combined with Omeprazole.
Cisapride	Cisapride The risk or severity of QTc prolongation can be increased when Cisapride is combined with Zonisamide.
Gabapentin	Gabapentin The risk or severity of adverse effects can be increased when Zonisamide is combined with Gabapentin.
Fluvastatin	Fluvastatin The metabolism of Zonisamide can be decreased when combined with Fluvastatin.
Venlafaxine	Venlafaxine The risk or severity of adverse effects can be increased when Venlafaxine is combined with Zonisamide.
Fluvoxamine	Fluvoxamine The metabolism of Zonisamide can be decreased when combined with Fluvoxamine.
Nefazodone	Nefazodone The risk or severity of adverse effects can be increased when Nefazodone is combined with Zonisamide.
Lamotrigine	Lamotrigine Lamotrigine may increase the arrhythmogenic activities of Zonisamide.
Losartan	Losartan Zonisamide may increase the arrhythmogenic activities of Losartan.
Valacyclovir	Valacyclovir Valaciclovir may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Tramadol	Tramadol The risk or severity of CNS depression can be increased when Zonisamide is combined with Tramadol.
Carboplatin Injection	Carboplatin Injection Carboplatin may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Moexipril	Moexipril The risk or severity of QTc prolongation can be increased when Moexipril is combined with Zonisamide.
Lansoprazole	Lansoprazole The metabolism of Zonisamide can be decreased when combined with Lansoprazole.
Ifosfamide Injection	Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Zonisamide.
Nicardipine	Nicardipine Zonisamide may increase the arrhythmogenic activities of Nicardipine.
Bupropion	Bupropion The risk or severity of adverse effects can be increased when Zonisamide is combined with Bupropion.
Ticlopidine	Ticlopidine The metabolism of Zonisamide can be decreased when combined with Ticlopidine.
Saquinavir	Saquinavir The metabolism of Saquinavir can be decreased when combined with Zonisamide.
Metformin	Metformin The risk or severity of lactic acidosis can be increased when Zonisamide is combined with Metformin.
Dalteparin Injection	Dalteparin Injection The risk or severity of hyperkalemia can be increased when Zonisamide is combined with Dalteparin.
Nisoldipine	Nisoldipine Nisoldipine may increase the arrhythmogenic activities of Zonisamide.
Lamivudine	Lamivudine Lamivudine may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Riluzole	Riluzole The risk or severity of adverse effects can be increased when Riluzole is combined with Zonisamide.
Acarbose	Acarbose The therapeutic efficacy of Acarbose can be increased when used in combination with Zonisamide.
Glimepiride	Glimepiride Zonisamide may increase the arrhythmogenic activities of Glimepiride.
Gemcitabine Injection	Gemcitabine Injection The serum concentration of Zonisamide can be increased when it is combined with Gemcitabine.
Indinavir	Indinavir The metabolism of Zonisamide can be decreased when combined with Indinavir.
Ritonavir	Ritonavir The serum concentration of Zonisamide can be increased when it is combined with Ritonavir.
Docetaxel Injection	Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Zonisamide.
Cidofovir Injection	Cidofovir Injection Cidofovir may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Meropenem Injection	Meropenem Injection Meropenem may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Clomipramine	Clomipramine The metabolism of Clomipramine can be decreased when combined with Zonisamide.
Zafirlukast	Zafirlukast The metabolism of Zonisamide can be decreased when combined with Zafirlukast.
Fosfomycin	Fosfomycin Fosfomycin may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Mirtazapine	Mirtazapine Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Trandolapril	Trandolapril The risk or severity of hyperkalemia can be increased when Trandolapril is combined with Zonisamide.
Topiramate	Topiramate The risk or severity of adverse effects can be increased when Topiramate is combined with Zonisamide.
Valsartan	Valsartan The risk or severity of hyperkalemia can be increased when Valsartan is combined with Zonisamide.
Insulin Lispro Injection	Insulin Lispro Injection The therapeutic efficacy of Insulin lispro can be increased when used in combination with Zonisamide.
Pramipexole	Pramipexole Zonisamide may increase the sedative activities of Pramipexole.
Donepezil	Donepezil The risk or severity of adverse effects can be increased when Donepezil is combined with Zonisamide.
Nelfinavir	Nelfinavir The metabolism of Zonisamide can be decreased when combined with Nelfinavir.
Fexofenadine	Fexofenadine The serum concentration of Fexofenadine can be increased when it is combined with Zonisamide.
Azithromycin	Azithromycin The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Azithromycin.
Carvedilol	Carvedilol The risk or severity of bradycardia can be increased when Carvedilol is combined with Zonisamide.
Nilutamide	Nilutamide The metabolism of Zonisamide can be decreased when combined with Nilutamide.
Flutamide	Flutamide Flutamide may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Selegiline	Selegiline The risk or severity of adverse effects can be increased when Zonisamide is combined with Selegiline.
Bicalutamide	Bicalutamide The metabolism of Zonisamide can be decreased when combined with Bicalutamide.
Sertraline	Sertraline The risk or severity of adverse effects can be increased when Zonisamide is combined with Sertraline.
Propafenone	Propafenone The risk or severity of bradycardia can be increased when Zonisamide is combined with Propafenone.
Letrozole	Letrozole The metabolism of Zonisamide can be decreased when combined with Letrozole.
Irbesartan	Irbesartan The risk or severity of hyperkalemia can be increased when Zonisamide is combined with Irbesartan.
Tamsulosin	Tamsulosin The risk or severity of hypotension can be increased when Tamsulosin is combined with Zonisamide.
Ropinirole	Ropinirole Zonisamide may increase the sedative activities of Ropinirole.
Finasteride	Finasteride The metabolism of Finasteride can be decreased when combined with Zonisamide.
Quetiapine	Quetiapine Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.
Cefepime Injection	Cefepime Injection Cefepime may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Cefprozil	Cefprozil Cefprozil may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Cefpodoxime	Cefpodoxime Cefpodoxime may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Cetirizine	Cetirizine The risk or severity of adverse effects can be increased when Cetirizine is combined with Zonisamide.
Paroxetine	Paroxetine The risk or severity of adverse effects can be increased when Zonisamide is combined with Paroxetine.
Tolcapone	Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Zonisamide.
Citalopram	Citalopram The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Citalopram.
Capecitabine	Capecitabine Zonisamide may increase the excretion rate of Capecitabine which could result in a lower serum level and potentially a reduction in efficacy.
Efavirenz	Efavirenz The serum concentration of Zonisamide can be decreased when it is combined with Efavirenz.
Abacavir	Abacavir Zonisamide may increase the excretion rate of Abacavir which could result in a lower serum level and potentially a reduction in efficacy.
Sildenafil	Sildenafil The metabolism of Sildenafil can be decreased when combined with Zonisamide.
Pioglitazone	Pioglitazone The therapeutic efficacy of Pioglitazone can be increased when used in combination with Zonisamide.
Celecoxib	Celecoxib Celecoxib may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Rosiglitazone	Rosiglitazone The therapeutic efficacy of Rosiglitazone can be increased when used in combination with Zonisamide.
Tolterodine	Tolterodine Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Tolterodine.
Thalidomide	Thalidomide Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Oseltamivir	Oseltamivir Oseltamivir may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Colesevelam	Colesevelam Colesevelam can cause a decrease in the absorption of Zonisamide resulting in a reduced serum concentration and potentially a decrease in efficacy.
Balsalazide	Balsalazide The risk or severity of adverse effects can be increased when Balsalazide is combined with Zonisamide.
Nateglinide	Nateglinide The therapeutic efficacy of Nateglinide can be increased when used in combination with Zonisamide.
Galantamine	Galantamine The risk or severity of QTc prolongation can be increased when Galantamine is combined with Zonisamide.
Levetiracetam	Levetiracetam The risk or severity of adverse effects can be increased when Zonisamide is combined with Levetiracetam.
Rabeprazole	Rabeprazole The metabolism of Zonisamide can be decreased when combined with Rabeprazole.