Is Inositol Safe With Ozempic (Semaglutide)?

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Our drug-herbal interaction checker lists a potential interaction between semaglutide (generic for Rybelsus, Ozempic, Wegovy) and inositol.

This interaction is based on the fact that semaglutide is an antidiabetic medication and will lower blood sugar levels. Inositol has also been reported to have antidiabetic effects. Therefore, the combination of semaglutide and inositol could theoretically have additive effects, increasing the risk of hypoglycemia.

Additional Details

Semaglutide is a prescription drug available under several brand names, including Rybelsus and Ozempic, which are used to treat diabetes by lowering blood sugar. Semaglutide works by mimicking the action of a hormone called glucagon-like peptide-1 (GLP-1). GLP-1 increases insulin secretion in response to high blood glucose levels, decreases glucagon secretion (which reduces glucose production in the liver), slows gastric emptying, and promotes satiety by acting on the brain's appetite centers. These actions help improve blood sugar control and assist in weight management.

Inositol has been reported to help lower blood sugar by improving the body's sensitivity to insulin. D-chiro-inositol and myo-inositol, two forms of inositol, act as messengers for insulin signals, enhancing glucose utilization and storage. They help balance molecules involved in glucose metabolism and increase adiponectin levels, a hormone that improves insulin sensitivity.

Both inositol and semaglutide, on their own, have a very low risk of causing hypoglycemia (low blood sugar). However, if taken together, they may have additive effects and increase the risk of blood sugar dropping too low. While this risk is likely quite low, and there are no specific studies reporting this interaction, it is good to be aware of it regardless.

I always recommend talking to your doctor before starting any new supplements. While I wouldn't expect you to be at significant risk for hypoglycemia with the combination of inositol and Ozempic, it's always good to be appropriately monitored.

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