Can You Take Advil And Tylenol #3 Together?

In our latest question and answer, our pharmacist discusses whether or not Advil can safely be taken with Tylenol #3 (acetaminophen; codeine).

Question

Can I take one Advil and one acetaminophen-codeine #3 300-30 MG Tab at the same time? I have a headache and hurt my back.

Asked by Jack On Sep 16, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Sep 16, 2022
Last updated Apr 28, 2024

Key points

  • Advil (ibuprofen) and Tylenol #3 (acetaminophen; codeine) can safely be taken together. There are no known drug interactions.

Answer

Hello and thanks for reaching out to us. Yes, you can take Advil (ibuprofen) with acetaminophen-codeine #3 (also known as Tylenol #3). There is no known interaction between them.

We have written previously about taking Tylenol and Advil together, which can be found here: 'Can You Take Advil And Tylenol Be Taken Together?'.

In that article, I explain that Advil and Tylenol (acetaminophen) work in different ways, and that studies show that the combination of both can be more effective at treating pain than either drug alone.

Now, for this question, we are adding in the fact that you are taking acetaminophen which is combined with codeine. Fortunately, Advil is safe to take with that too.

Remember to take acetaminophen; codeine only as prescribed. It is a controlled substance and is generally only used for acute purposes. If you find you need additional pain relief, be sure to speak with your doctor.

Final Words

Thanks again for your question and reach back out anytime!

About Acetaminophen With Codeine

The combination of acetaminophen and codeine is used to relieve mild to moderate pain. Acetaminophen is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers). It works by changing the way the body senses pain and by cooling the body.

Codeine belongs to a class of medications called opiate (narcotic) analgesics and to a class of medications called antitussives. When codeine is used to treat pain, it works by changing the way the brain and nervous system respond to pain. When codeine is used to reduce coughing, it works by decreasing the activity in the part of the brain that causes coughing.

About Ibuprofen

Nonprescription ibuprofen is used to reduce fever and to relieve minor aches and pain from headaches, muscle aches, arthritis, menstrual periods, the common cold, toothaches, and backaches. Ibuprofen is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation.

References

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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