Can You Safely Take Marine Collagen With Xarelto?
In our latest question and answer, the pharmacist discusses the safety of taking marine collagen while taking Xarelto.
Can I take marine collagen while I’m taking Xarelto?
Jun 27, 2025- There are no known drug interactions between Xarelto and marine collagen, and available evidence suggests it is generally safe to take them together.
- If you have any specific health concerns, it's a good idea to talk with your healthcare provider before starting any new supplement.
Answer
Hello and thanks for reaching out to us!
Xarelto And Marine Collagen
Xarelto (rivaroxaban) is a prescription anticoagulant used to help prevent and treat blood clots. Because medications like Xarelto can have serious interactions, it’s always a good idea to check for any potential issues before combining them with over-the-counter supplements such as marine collagen. Always ask your doctor or pharmacist!
Collagen peptides are a very popular dietary supplement. They are small protein fragments produced by breaking down collagen through a process called hydrolysis. Typically, collagen is first converted to gelatin and then treated with specific enzymes to produce shorter, water-soluble peptides.
Marine collagen is specifically sourced from fish skin, scales, and bones. It contains the same types of amino acids as other collagen sources but is often marketed as being more easily absorbed. It can also be a good option for those who are pescatarian (i.e., individuals who eat fish but avoid other meats).
The exact makeup of marine collagen can vary depending on the species of fish and the extraction method used, but it is essentially the same type of protein as collagen peptides derived from pigs or cows.
Interaction Concerns?
The good news is there are no known drug interactions between Xarelto and collagen supplements, including marine-derived collagen. Available evidence suggests it is generally safe to take them together. In fact, our 'collagen' page doesn't list any serious drug interactions with it.
For a detailed review of this specific combination, you can visit our comprehensive interaction page here: Collagen Peptides with Xarelto.
Final Words
If you're taking Xarelto, there is no evidence suggesting you need to avoid marine collagen or other collagen supplements. However, if you have any specific health concerns, it's always a good idea to talk with your healthcare provider before starting any new supplement.
Thanks again for reaching out!
References & sources
- Sibilla S, Godfrey M, Brewer S, Budh-Raja A, Genovese L. An overview of the beneficial effects of hydrolysed collagen as a nutraceutical on skin properties: Scientific background and clinical studies. Open Neutraceut J. 2015;8:29-42. — Bentham Archives
- Effects of Different Vitamin C-Enriched Collagen Derivatives on Collagen Synthesis — PubMed
- Xarelto Prescribing Information — Janssen
Glossary — Terms in This Answer
- Anticoagulant
- A medication that helps prevent blood clots by making blood less likely to clot.
- Rivaroxaban
- The generic chemical name for the prescription drug Xarelto.
- Drug interactions
- Unwanted effects that can happen when two medications or substances are taken together and affect how each other works.
- Collagen peptides
- Small fragments of protein created by breaking down collagen into smaller, easier-to-absorb pieces.
- Hydrolysis
- A chemical process that breaks down a substance by adding water, used here to create collagen peptides.
- Gelatin
- A protein substance made by cooking collagen, which is then further processed into collagen peptides.
- Amino acids
- Building blocks that make up proteins and are essential for various functions in the body.
- Pescatarian
- A person who eats fish and seafood but avoids eating other types of meat.
Dr. Brian Staiger, PharmD
Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified
Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...
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