Primidone

Generic name: Pronounced as (pri' mi done)
Brand names
  • Mysoline®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 05/15/2020

Primidone is used alone or with other medications to control certain types of seizures. Primidone is in a class of medications called anticonvulsants. It works by decreasing abnormal electrical activity in the brain.

Primidone comes as a tablet to take by mouth. It is usually taken 3 to 4 times a day. Take primidone at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take primidone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start you on a low dose of primidone and gradually increase your dose, not more often than once every 3 days. If you are taking another medication to treat your seizures and your doctor wants you to begin taking primidone instead, your doctor will gradually decrease your dose of the other medication and increase your dose of primidone over a period of at least 2 weeks.

Primidone may help control your condition but will not cure it. It may take several weeks or longer for you to feel the full benefit of this medication. Continue to take primidone even if you feel well. Do not stop taking primidone without talking to your doctor, even if you experience side effects such as unusual changes in behavior or mood. If you suddenly stop taking primidone, your seizures may become worse. Your doctor will probably decrease your dose gradually.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Before taking primidone,

  • tell your doctor and pharmacist if you are allergic to primidone, phenobarbital or any other medications.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin); antidepressants; disulfiram (Antabuse); doxycycline (Vibramycin); griseofulvin (Grifulvin); medications for anxiety, mental illness, and pain; other medications for seizures such as oxcarbazepine (Trileptal), phenobarbital, phenytoin (Dilantin), and valproic acid (Depakene, Depakote); oral contraceptives (birth control pills); oral steroids such as dexamethasone (Decadron, Dexone) and prednisone (Deltasone); sedatives; sleeping pills; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have or have ever had porphyria (condition in which certain natural substances build up in the body and may cause stomach pain, changes in thinking and behavior, or other symptoms).

  • tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while taking primidone, call your doctor.

  • tell your doctor if you are breast-feeding. If you breast-feed during your treatment, your baby may receive some primidone in the breast milk. Watch your baby closely for drowsiness or poor weight gain.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking primidone.

  • you should know that this medication may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.

  • talk to your doctor about the safe use of alcohol while you are taking this medication.

  • you should know that your mental health may change in unexpected ways and you may become suicidal (thinking about harming or killing yourself or planning or trying to do so) while you are taking primidone. A small number of adults and children 5 years of age and older (about 1 in 500 people) who took anticonvulsants such as primidone to treat various conditions during clinical studies became suicidal during their treatment. Some of these people developed suicidal thoughts and behavior as early as one week after they started taking the medication. There is a risk that you may experience changes in your mental health if you take an anticonvulsant medication such as primidone, but there may also be a risk that you will experience changes in your mental health if your condition is not treated. You and your doctor will decide whether the risks of taking an anticonvulsant medication are greater than the risks of not taking the medication. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: panic attacks; agitation or restlessness; new or worsening irritability, anxiety, or depression; acting on dangerous impulses; difficulty falling asleep or staying asleep; aggressive, angry, or violent behavior; mania (frenzied, abnormally excited mood); talking or thinking about wanting to hurt yourself or to end your life; withdrawing from friends and family; preoccupation with death and dying; giving away prized possessions; or any other unusual changes in behavior or mood. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for the missed one.

  • Primidone may cause side effects. Call your doctor if any of these symptoms are severe or do not go away:

    • excessive tiredness

    • dizziness

    • difficulty coordinating movements

    • nausea

    • vomiting

    • loss of appetite

    • double vision

    • uncontrollable eye movements

    • decrease in sexual ability

  • Some side effects can be serious. If you experience the following symptom, call your doctor immediately:

    • rash

  • Primidone may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to primidone.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

  • Desoxyphenobarbital
  • Primaclone

Drug Interaction
Montelukast Montelukast The metabolism of Primidone can be decreased when combined with Montelukast.
Leflunomide Leflunomide The metabolism of Leflunomide can be increased when combined with Primidone.
Delavirdine Delavirdine The metabolism of Primidone can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Primidone can be decreased when combined with Nevirapine.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be increased when combined with Primidone.
Dolasetron Dolasetron The risk or severity of adverse effects can be increased when Dolasetron is combined with Primidone.
Aminophylline Aminophylline The therapeutic efficacy of Primidone can be decreased when used in combination with Aminophylline.
Anagrelide Anagrelide The metabolism of Anagrelide can be increased when combined with Primidone.
Bisacodyl Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Primidone.
Candesartan Candesartan The metabolism of Primidone can be decreased when combined with Candesartan.
Cilostazol Cilostazol The metabolism of Cilostazol can be increased when combined with Primidone.
Clopidogrel Clopidogrel The metabolism of Primidone can be increased when combined with Clopidogrel.
Diphenoxylate Diphenoxylate The risk or severity of adverse effects can be increased when Primidone is combined with Diphenoxylate.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The metabolism of Conjugated estrogens can be increased when combined with Primidone.
Fenofibrate Fenofibrate The metabolism of Fenofibrate can be increased when combined with Primidone.
Guanfacine Guanfacine The metabolism of Guanfacine can be increased when combined with Primidone.
Magnesium Hydroxide Magnesium Hydroxide The therapeutic efficacy of Magnesium hydroxide can be decreased when used in combination with Primidone.
Magnesium Oxide Magnesium Oxide The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Primidone.
Mycophenolate Mycophenolate The metabolism of Mycophenolic acid can be increased when combined with Primidone.
Naratriptan Naratriptan The risk or severity of adverse effects can be increased when Primidone is combined with Naratriptan.
Paregoric Paregoric The risk or severity of adverse effects can be increased when Primidone is combined with Morphine.
Penbutolol Penbutolol The serum concentration of Acebutolol can be decreased when it is combined with Primidone.
Pentazocine Pentazocine The risk or severity of adverse effects can be increased when Pentazocine is combined with Primidone.
Polyethylene glycol-electrolyte solution (PEG-ES) Polyethylene glycol-electrolyte solution (PEG-ES) The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Primidone.
Psyllium Psyllium The therapeutic efficacy of Plantago seed can be decreased when used in combination with Primidone.
Ranitidine Ranitidine The metabolism of Ranitidine can be increased when combined with Primidone.
Reserpine Reserpine Primidone may increase the hypotensive activities of Reserpine.
Rizatriptan Rizatriptan The risk or severity of adverse effects can be increased when Primidone is combined with Rizatriptan.
Sumatriptan Sumatriptan The risk or severity of adverse effects can be increased when Sumatriptan is combined with Primidone.
Tacrolimus Tacrolimus The metabolism of Tacrolimus can be increased when combined with Primidone.
Tizanidine Tizanidine The metabolism of Tizanidine can be increased when combined with Primidone.
Zolmitriptan Zolmitriptan The metabolism of Zolmitriptan can be increased when combined with Primidone.
Doxycycline Injection Doxycycline Injection The serum concentration of Doxycycline can be decreased when it is combined with Primidone.
Fluconazole Injection Fluconazole Injection The metabolism of Primidone can be decreased when combined with Fluconazole.
Hydromorphone Injection Hydromorphone Injection The risk or severity of adverse effects can be increased when Hydromorphone is combined with Primidone.
Meperidine Injection Meperidine Injection Primidone may increase the hypotensive and central nervous system depressant (CNS depressant) activities of Meperidine.
Metoclopramide Injection Metoclopramide Injection The risk or severity of sedation can be increased when Metoclopramide is combined with Primidone.
Metronidazole Injection Metronidazole Injection The metabolism of Metronidazole can be increased when combined with Primidone.
Morphine Injection Morphine Injection The risk or severity of adverse effects can be increased when Primidone is combined with Morphine.
Zidovudine Injection Zidovudine Injection The metabolism of Primidone can be increased when combined with Zidovudine.
Altretamine Altretamine The serum concentration of Primidone can be decreased when it is combined with Amphetamine.
Cyclosporine Cyclosporine The metabolism of Cyclosporine can be increased when combined with Primidone.
Ondansetron Ondansetron The risk or severity of adverse effects can be increased when Primidone is combined with Ondansetron.
Granisetron Granisetron The risk or severity of adverse effects can be increased when Primidone is combined with Granisetron.
Torsemide Torsemide The metabolism of Primidone can be decreased when combined with Torasemide.
Olanzapine Olanzapine The metabolism of Olanzapine can be increased when combined with Primidone.
Alosetron Alosetron The metabolism of Alosetron can be increased when combined with Primidone.
Dofetilide Dofetilide The metabolism of Dofetilide can be increased when combined with Primidone.
Entacapone Entacapone The risk or severity of adverse effects can be increased when Entacapone is combined with Primidone.
Eprosartan Eprosartan Primidone may increase the hypotensive activities of Eprosartan.
Hydroxychloroquine Hydroxychloroquine The therapeutic efficacy of Hydroxychloroquine can be decreased when used in combination with Primidone.
Meloxicam Meloxicam The metabolism of Meloxicam can be decreased when combined with Primidone.
Orlistat Orlistat Orlistat can cause a decrease in the absorption of Primidone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Oxcarbazepine Oxcarbazepine The metabolism of Primidone can be decreased when combined with Oxcarbazepine.
Pantoprazole Pantoprazole The metabolism of Primidone can be decreased when combined with Pantoprazole.
Telmisartan Telmisartan Primidone may increase the hypotensive activities of Telmisartan.
Zaleplon Zaleplon The risk or severity of adverse effects can be increased when Primidone is combined with Zaleplon.
Anakinra Anakinra The metabolism of Primidone can be increased when combined with Anakinra.
Desloratadine Desloratadine The risk or severity of adverse effects can be increased when Primidone is combined with Desloratadine.
Linezolid Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Primidone.
Rivastigmine Rivastigmine The therapeutic efficacy of Rivastigmine can be decreased when used in combination with Primidone.
Trimipramine Trimipramine The metabolism of Trimipramine can be decreased when combined with Primidone.
Etanercept Injection Etanercept Injection The metabolism of Primidone can be increased when combined with Etanercept.
Glycopyrrolate Glycopyrrolate Primidone may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
Modafinil Modafinil The metabolism of Primidone can be decreased when combined with Modafinil.
Perindopril Perindopril Perindopril may increase the hypotensive activities of Primidone.
Tenofovir Tenofovir The metabolism of Tenofovir can be increased when combined with Primidone.
Sirolimus Sirolimus The metabolism of Sirolimus can be increased when combined with Primidone.
Epinephrine Injection Epinephrine Injection The metabolism of Primidone can be decreased when combined with Epinephrine.
Eplerenone Eplerenone Primidone may increase the hypotensive activities of Eplerenone.
Escitalopram Escitalopram The risk or severity of adverse effects can be increased when Primidone is combined with Escitalopram.
Olmesartan Olmesartan Primidone may increase the hypotensive activities of Olmesartan.
Zonisamide Zonisamide The metabolism of Primidone can be decreased when combined with Zonisamide.
Adalimumab Injection Adalimumab Injection The metabolism of Primidone can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be increased when combined with Primidone.
Atomoxetine Atomoxetine The risk or severity of adverse effects can be increased when Atomoxetine is combined with Primidone.
Dexmethylphenidate Dexmethylphenidate The serum concentration of the active metabolites of Primidone can be increased when Primidone is used in combination with Dexmethylphenidate.
Ezetimibe Ezetimibe The metabolism of Ezetimibe can be increased when combined with Primidone.
Atazanavir Atazanavir The metabolism of Atazanavir can be increased when combined with Primidone.
Almotriptan Almotriptan The risk or severity of adverse effects can be increased when Primidone is combined with Almotriptan.
Eletriptan Eletriptan The risk or severity of adverse effects can be increased when Eletriptan is combined with Primidone.
Mefloquine Mefloquine The therapeutic efficacy of Primidone can be decreased when used in combination with Mefloquine.
Polyethylene Glycol 3350 Polyethylene Glycol 3350 The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Primidone.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be increased when combined with Primidone.
Aprepitant Aprepitant The metabolism of Primidone can be decreased when combined with Aprepitant.
Memantine Memantine The metabolism of Primidone can be decreased when combined with Memantine.
Tegaserod Tegaserod The therapeutic efficacy of Tegaserod can be decreased when used in combination with Primidone.
Frovatriptan Frovatriptan The metabolism of Frovatriptan can be increased when combined with Primidone.
Progesterone Progesterone The metabolism of Progesterone can be increased when combined with Primidone.
Apomorphine Injection Apomorphine Injection Primidone may increase the hypotensive activities of Apomorphine.
Infliximab Injection Infliximab Injection The metabolism of Primidone can be increased when combined with Infliximab.
Oxandrolone Oxandrolone The metabolism of Primidone can be decreased when combined with Oxandrolone.
Protriptyline Protriptyline The metabolism of Protriptyline can be increased when combined with Primidone.
Rifaximin Rifaximin The metabolism of Primidone can be increased when combined with Rifaximin.
Duloxetine Duloxetine The metabolism of Duloxetine can be increased when combined with Primidone.
Norethindrone Norethindrone The metabolism of Norethisterone can be increased when combined with Primidone.
Trospium Trospium Primidone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Bosentan Bosentan The metabolism of Primidone can be increased when combined with Bosentan.
Cinacalcet Cinacalcet The metabolism of Cinacalcet can be increased when combined with Primidone.
Erlotinib Erlotinib The metabolism of Erlotinib can be increased when combined with Primidone.
Eszopiclone Eszopiclone The risk or severity of CNS depression can be increased when Primidone is combined with Eszopiclone.
Ganciclovir Ganciclovir The therapeutic efficacy of Primidone can be decreased when used in combination with Ganciclovir.
Solifenacin Solifenacin Primidone may increase the central nervous system depressant (CNS depressant) activities of Solifenacin.
Valganciclovir Valganciclovir The therapeutic efficacy of Primidone can be decreased when used in combination with Valganciclovir.
Voriconazole Voriconazole The serum concentration of Voriconazole can be decreased when it is combined with Primidone.
Dextroamphetamine Dextroamphetamine The serum concentration of Primidone can be decreased when it is combined with Amphetamine.
Entecavir Entecavir The metabolism of Entecavir can be increased when combined with Primidone.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The metabolism of Primidone can be increased when combined with Peginterferon alfa-2b.
Sodium Oxybate Sodium Oxybate Primidone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Isocarboxazid Isocarboxazid Primidone may increase the hypotensive activities of Isocarboxazid.
Ramelteon Ramelteon The metabolism of Ramelteon can be increased when combined with Primidone.
Darifenacin Darifenacin Primidone may increase the central nervous system depressant (CNS depressant) activities of Darifenacin.
Fentanyl Fentanyl The risk or severity of adverse effects can be increased when Primidone is combined with Fentanyl.
Pregabalin Pregabalin The therapeutic efficacy of Primidone can be increased when used in combination with Pregabalin.
Deferasirox Deferasirox The serum concentration of Deferasirox can be decreased when it is combined with Primidone.
Tipranavir Tipranavir The metabolism of Primidone can be decreased when combined with Tipranavir.
Felbamate Felbamate The serum concentration of Phenobarbital, an active metabolite of Primidone, can be increased when used in combination with Felbamate.
Ranolazine Ranolazine The metabolism of Ranolazine can be increased when combined with Primidone.
Abatacept Injection Abatacept Injection The metabolism of Primidone can be increased when combined with Abatacept.
Rasagiline Rasagiline The metabolism of Rasagiline can be increased when combined with Primidone.
Imatinib Imatinib The metabolism of Imatinib can be increased when combined with Primidone.
Gefitinib Gefitinib The metabolism of Gefitinib can be increased when combined with Primidone.
Paliperidone Paliperidone The risk or severity of adverse effects can be increased when Primidone is combined with Paliperidone.
Exemestane Exemestane The metabolism of Exemestane can be increased when combined with Primidone.
Bortezomib Bortezomib The metabolism of Primidone can be increased when combined with Bortezomib.
Clofarabine Injection Clofarabine Injection Primidone may increase the hypotensive activities of Clofarabine.
Fulvestrant Injection Fulvestrant Injection The metabolism of Fulvestrant can be increased when combined with Primidone.
Lubiprostone Lubiprostone The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Primidone.
Primaquine Primaquine The metabolism of Primaquine can be increased when combined with Primidone.
Aliskiren Aliskiren Primidone may increase the hypotensive activities of Aliskiren.
Darunavir Darunavir The serum concentration of Darunavir can be decreased when it is combined with Primidone.
Pemetrexed Injection Pemetrexed Injection The metabolism of Pemetrexed can be increased when combined with Primidone.
Dimenhydrinate Dimenhydrinate The risk or severity of adverse effects can be increased when Primidone is combined with Dimenhydrinate.
Lisdexamfetamine Lisdexamfetamine The serum concentration of Primidone can be decreased when it is combined with Lisdexamfetamine.
Nabilone Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Primidone.
Retapamulin Retapamulin The metabolism of Retapamulin can be increased when combined with Primidone.
Sorafenib Sorafenib The metabolism of Primidone can be increased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Sunitinib can be increased when combined with Primidone.
Dronabinol Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Primidone.
Lapatinib Lapatinib The metabolism of Lapatinib can be increased when combined with Primidone.
Levocetirizine Levocetirizine The risk or severity of adverse effects can be increased when Primidone is combined with Levocetirizine.
Dasatinib Dasatinib The metabolism of Dasatinib can be increased when combined with Primidone.
Mexiletine Mexiletine The metabolism of Mexiletine can be increased when combined with Primidone.
Armodafinil Armodafinil The metabolism of Primidone can be decreased when combined with Armodafinil.
Paclitaxel (with polyoxyethylated castor oil) Injection Paclitaxel (with polyoxyethylated castor oil) Injection The therapeutic efficacy of Castor oil can be decreased when used in combination with Primidone.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be increased when combined with Primidone.
Maraviroc Maraviroc The metabolism of Maraviroc can be increased when combined with Primidone.
Nilotinib Nilotinib The metabolism of Primidone can be increased when combined with Nilotinib.
Raltegravir Raltegravir The metabolism of Raltegravir can be increased when combined with Primidone.
Bexarotene Bexarotene The metabolism of Primidone can be decreased when combined with Bexarotene.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Primidone can be decreased when combined with Chloramphenicol.
Betaine Betaine The therapeutic efficacy of Primidone can be decreased when used in combination with Glycine betaine.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Primidone is combined with Botulinum toxin type A.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Primidone is combined with Botulinum Toxin Type B.
Etravirine Etravirine The metabolism of Etravirine can be increased when combined with Primidone.
Arsenic Trioxide Injection Arsenic Trioxide Injection Primidone may increase the hypotensive activities of Arsenic trioxide.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Primidone can be increased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The risk or severity of adverse effects can be increased when Primidone is combined with Desvenlafaxine.
Nebivolol Nebivolol The metabolism of Nebivolol can be decreased when combined with Primidone.
Tretinoin Tretinoin Tretinoin may increase the hypotensive activities of Primidone.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Primidone.
Leucovorin Injection Leucovorin Injection The serum concentration of Primidone can be decreased when it is combined with Leucovorin.
Flecainide Flecainide The metabolism of Primidone can be increased when combined with Flecainide.
Certolizumab Injection Certolizumab Injection The metabolism of Primidone can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be increased when combined with Primidone.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be increased when combined with Primidone.
Levoleucovorin Injection Levoleucovorin Injection The serum concentration of Primidone can be decreased when it is combined with Levoleucovorin.
Praziquantel Praziquantel The metabolism of Praziquantel can be increased when combined with Primidone.
Rufinamide Rufinamide The serum concentration of Primidone can be increased when it is combined with Rufinamide.
Midazolam Midazolam The risk or severity of adverse effects can be increased when Midazolam is combined with Primidone.
Naltrexone Injection Naltrexone Injection The risk or severity of adverse effects can be increased when Primidone is combined with Naltrexone.
Eltrombopag Eltrombopag The metabolism of Eltrombopag can be increased when combined with Primidone.
Milnacipran Milnacipran The metabolism of Milnacipran can be increased when combined with Primidone.
Dexlansoprazole Dexlansoprazole The metabolism of Primidone can be decreased when combined with Dexlansoprazole.
Sodium Phosphate Sodium Phosphate The therapeutic efficacy of Primidone can be decreased when used in combination with Sodium phosphate, monobasic.
Fesoterodine Fesoterodine Primidone may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine.
Betaxolol Betaxolol The metabolism of Betaxolol can be increased when combined with Primidone.
Iloperidone Iloperidone The risk or severity of adverse effects can be increased when Primidone is combined with Iloperidone.
Prasugrel Prasugrel The metabolism of Prasugrel can be decreased when combined with Primidone.
Lacosamide Lacosamide The metabolism of Lacosamide can be increased when combined with Primidone.
Everolimus Everolimus The metabolism of Everolimus can be increased when combined with Primidone.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Tolvaptan can be increased when combined with Primidone.
Dronedarone Dronedarone The metabolism of Dronedarone can be increased when combined with Primidone.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Primidone is combined with Botulinum toxin type A.
Palonosetron Injection Palonosetron Injection The risk or severity of adverse effects can be increased when Palonosetron is combined with Primidone.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be increased when combined with Primidone.
Tapentadol Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Primidone.
Topotecan Topotecan Primidone may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Golimumab Injection Golimumab Injection The metabolism of Primidone can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Pazopanib can be increased when combined with Primidone.
Asenapine Asenapine The metabolism of Asenapine can be increased when combined with Primidone.
Vigabatrin Vigabatrin The risk or severity of adverse effects can be increased when Primidone is combined with Vigabatrin.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Primidone.
Albendazole Albendazole The metabolism of Albendazole can be increased when combined with Primidone.
Ulipristal Ulipristal The metabolism of Ulipristal can be increased when combined with Primidone.
Levonorgestrel Levonorgestrel The metabolism of Levonorgestrel can be increased when combined with Primidone.
Oxymorphone Oxymorphone The risk or severity of adverse effects can be increased when Primidone is combined with Oxymorphone.
Tocilizumab Injection Tocilizumab Injection The metabolism of Primidone can be increased when combined with Tocilizumab.
Fingolimod Fingolimod The metabolism of Fingolimod can be increased when combined with Primidone.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Primidone is combined with Botulinum toxin type A.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be increased when combined with Primidone.
Lurasidone Lurasidone The risk or severity of adverse effects can be increased when Primidone is combined with Lurasidone.
Acetaminophen Injection Acetaminophen Injection Primidone may increase the hepatotoxic activities of Acetaminophen.
Vilazodone Vilazodone The metabolism of Vilazodone can be increased when combined with Primidone.
Denileukin Diftitox Injection Denileukin Diftitox Injection Primidone may increase the hypotensive activities of Aldesleukin.
Terbutaline Injection Terbutaline Injection The therapeutic efficacy of Primidone can be decreased when used in combination with Terbutaline.
Azilsartan Azilsartan Primidone may increase the hypotensive activities of Azilsartan medoxomil.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be increased when combined with Primidone.
Roflumilast Roflumilast The metabolism of Roflumilast can be increased when combined with Primidone.
Linagliptin Linagliptin The metabolism of Linagliptin can be increased when combined with Primidone.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Primidone can be increased when combined with Cyclophosphamide.
Abiraterone Abiraterone The metabolism of Abiraterone can be increased when combined with Primidone.
Ticagrelor Ticagrelor The metabolism of Primidone can be decreased when combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be increased when combined with Primidone.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be increased when combined with Primidone.
Vandetanib Vandetanib The metabolism of Vandetanib can be increased when combined with Primidone.
Clobazam Clobazam The metabolism of Primidone can be decreased when combined with Clobazam.
Vemurafenib Vemurafenib The metabolism of Primidone can be increased when combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Primidone can be decreased when combined with Vismodegib.
Ivacaftor Ivacaftor The serum concentration of Ivacaftor can be decreased when it is combined with Primidone.
Axitinib Axitinib The metabolism of Axitinib can be increased when combined with Primidone.
Crizotinib Crizotinib The metabolism of Crizotinib can be increased when combined with Primidone.
Cabergoline Cabergoline The metabolism of Primidone can be increased when combined with Cabergoline.
Naloxone Injection Naloxone Injection The metabolism of Naloxone can be increased when combined with Primidone.
Ezogabine Ezogabine The risk or severity of adverse effects can be increased when Primidone is combined with Tiagabine.
Iloprost Iloprost Primidone may increase the hypotensive activities of Iloprost.
Enzalutamide Enzalutamide The metabolism of Primidone can be increased when combined with Enzalutamide.
Regorafenib Regorafenib The metabolism of Primidone can be increased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Bosutinib can be increased when combined with Primidone.
Linaclotide Linaclotide The therapeutic efficacy of Linaclotide can be decreased when used in combination with Primidone.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be increased when combined with Primidone.
Ponatinib Ponatinib The metabolism of Ponatinib can be increased when combined with Primidone.
Pomalidomide Pomalidomide The metabolism of Pomalidomide can be increased when combined with Primidone.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be increased when combined with Primidone.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Primidone.
Canagliflozin Canagliflozin The serum concentration of Canagliflozin can be decreased when it is combined with Primidone.
Methazolamide Methazolamide Primidone may increase the hypotensive activities of Methazolamide.
Dabrafenib Dabrafenib The serum concentration of Primidone can be decreased when it is combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Primidone.
Dolutegravir Dolutegravir The metabolism of Dolutegravir can be increased when combined with Primidone.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be increased when combined with Primidone.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be increased when combined with Primidone.
Perampanel Perampanel The metabolism of Perampanel can be increased when combined with Primidone.
Lomitapide Lomitapide The metabolism of Lomitapide can be increased when combined with Primidone.
Ketorolac Injection Ketorolac Injection The metabolism of Primidone can be decreased when combined with Ketorolac.
Obinutuzumab Injection Obinutuzumab Injection Primidone may increase the hypotensive activities of Obinutuzumab.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be increased when combined with Primidone.
Apremilast Apremilast The metabolism of Primidone can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Ceritinib can be increased when combined with Primidone.
Siltuximab Injection Siltuximab Injection The metabolism of Primidone can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The serum concentration of Eslicarbazepine can be decreased when it is combined with Primidone.
Belinostat Injection Belinostat Injection The metabolism of Belinostat can be increased when combined with Primidone.
Idelalisib Idelalisib The metabolism of Idelalisib can be increased when combined with Primidone.
Testosterone Injection Testosterone Injection The metabolism of Primidone can be decreased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Primidone can be decreased when combined with Oritavancin.
Empagliflozin Empagliflozin Primidone may increase the hypotensive activities of Empagliflozin.
Vorapaxar Vorapaxar The metabolism of Vorapaxar can be increased when combined with Primidone.
Hydrocodone Hydrocodone The metabolism of Hydrocodone can be increased when combined with Primidone.
Suvorexant Suvorexant Primidone may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Olaparib Olaparib The metabolism of Olaparib can be increased when combined with Primidone.
Methamphetamine Methamphetamine The serum concentration of Primidone can be decreased when it is combined with Metamfetamine.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be increased when combined with Primidone.
Riociguat Riociguat Primidone may increase the hypotensive activities of Riociguat.
Pirfenidone Pirfenidone The serum concentration of Pirfenidone can be decreased when it is combined with Primidone.
Nintedanib Nintedanib The metabolism of Nintedanib can be increased when combined with Primidone.
Secukinumab Injection Secukinumab Injection The metabolism of Primidone can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The risk or severity of adverse effects can be increased when Risperidone is combined with Primidone.
Palbociclib Palbociclib The metabolism of Palbociclib can be increased when combined with Primidone.
Lenvatinib Lenvatinib The metabolism of Primidone can be decreased when combined with Lenvatinib.
Naloxegol Naloxegol The metabolism of Primidone can be decreased when combined with Naloxegol.
Panobinostat Panobinostat The metabolism of Panobinostat can be increased when combined with Primidone.
Dinutuximab Injection Dinutuximab Injection Primidone may increase the hypotensive activities of Dinutuximab.
Haloperidol Injection Haloperidol Injection The risk or severity of CNS depression can be increased when Haloperidol is combined with Primidone.
Amiloride Amiloride Primidone may increase the hypotensive activities of Amiloride.
Sonidegib Sonidegib The metabolism of Sonidegib can be increased when combined with Primidone.
Flibanserin Flibanserin The risk or severity of adverse effects can be increased when Primidone is combined with Flibanserin.
Brexpiprazole Brexpiprazole The metabolism of Brexpiprazole can be increased when combined with Primidone.
Ziprasidone Injection Ziprasidone Injection The risk or severity of adverse effects can be increased when Primidone is combined with Ziprasidone.
Cariprazine Cariprazine The risk or severity of adverse effects can be increased when Primidone is combined with Cariprazine.
Eluxadoline Eluxadoline The risk or severity of constipation can be increased when Primidone is combined with Eluxadoline.
Cobimetinib Cobimetinib The metabolism of Cobimetinib can be increased when combined with Primidone.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be increased when combined with Primidone.
Osimertinib Osimertinib The metabolism of Osimertinib can be increased when combined with Primidone.
Alectinib Alectinib The metabolism of Alectinib can be increased when combined with Primidone.
Ixazomib Ixazomib The metabolism of Ixazomib can be increased when combined with Primidone.
Rifapentine Rifapentine The metabolism of Primidone can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Lesinurad can be decreased when combined with Primidone.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Primidone may increase the hypotensive activities of Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The metabolism of Primidone can be increased when combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection The risk or severity of adverse effects can be increased when Primidone is combined with Brivaracetam.
Venetoclax Venetoclax The metabolism of Venetoclax can be increased when combined with Primidone.
Cobicistat Cobicistat The serum concentration of Cobicistat can be decreased when it is combined with Primidone.
Pimavanserin Pimavanserin The risk or severity of adverse effects can be increased when Primidone is combined with Pimavanserin.
Diphenhydramine Injection Diphenhydramine Injection The risk or severity of adverse effects can be increased when Primidone is combined with Diphenhydramine.
Furosemide Injection Furosemide Injection The metabolism of Furosemide can be increased when combined with Primidone.
Rucaparib Rucaparib The metabolism of Primidone can be increased when combined with Rucaparib.
Ribociclib Ribociclib The metabolism of Ribociclib can be increased when combined with Primidone.
Brigatinib Brigatinib The metabolism of Brigatinib can be increased when combined with Primidone.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Doxepin can be increased when combined with Primidone.
Plecanatide Plecanatide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Primidone.
Deutetrabenazine Deutetrabenazine The risk or severity of sedation and somnolence can be increased when Primidone is combined with Deutetrabenazine.
Deflazacort Deflazacort The serum concentration of Deflazacort can be decreased when it is combined with Primidone.
Safinamide Safinamide The metabolism of Primidone can be decreased when combined with Safinamide.
Midostaurin Midostaurin The metabolism of Primidone can be increased when combined with Midostaurin.
Neratinib Neratinib The metabolism of Neratinib can be increased when combined with Primidone.
Enasidenib Enasidenib The metabolism of Primidone can be increased when combined with Enasidenib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be increased when combined with Primidone.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be increased when combined with Primidone.
Delafloxacin Delafloxacin The metabolism of Delafloxacin can be increased when combined with Primidone.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be increased when combined with Primidone.
Acalabrutinib Acalabrutinib The metabolism of Acalabrutinib can be increased when combined with Primidone.
Letermovir Letermovir The metabolism of Letermovir can be increased when combined with Primidone.
Tetrabenazine Tetrabenazine The risk or severity of sedation and somnolence can be increased when Primidone is combined with Tetrabenazine.
Buprenorphine Injection Buprenorphine Injection Primidone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Apalutamide Apalutamide The serum concentration of Primidone can be increased when it is combined with Apalutamide.
Avatrombopag Avatrombopag The metabolism of Primidone can be increased when combined with Avatrombopag.
Baricitinib Baricitinib The metabolism of Baricitinib can be increased when combined with Primidone.
Lofexidine Lofexidine The therapeutic efficacy of Primidone can be increased when used in combination with Lofexidine.
Binimetinib Binimetinib The metabolism of Binimetinib can be increased when combined with Primidone.
Ivosidenib Ivosidenib The metabolism of Ivosidenib can be increased when combined with Primidone.
Elagolix Elagolix The metabolism of Elagolix can be increased when combined with Primidone.
Cannabidiol Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Primidone.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be increased when combined with Primidone.
Duvelisib Duvelisib The metabolism of Duvelisib can be increased when combined with Primidone.
Stiripentol Stiripentol The serum concentration of Stiripentol can be decreased when it is combined with Primidone.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be increased when combined with Primidone.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Primidone.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be increased when combined with Primidone.
Rifamycin Rifamycin The metabolism of Primidone can be increased when combined with Rifamycin.
Prucalopride Prucalopride The metabolism of Prucalopride can be increased when combined with Primidone.
Magnesium Citrate Magnesium Citrate The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Primidone.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Primidone can be increased when combined with Emapalumab.
Siponimod Siponimod The therapeutic efficacy of Siponimod can be decreased when used in combination with Primidone.
Acyclovir Ophthalmic Acyclovir Ophthalmic The metabolism of Acyclovir can be increased when combined with Primidone.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be increased when combined with Primidone.
Esomeprazole Injection Esomeprazole Injection The metabolism of Primidone can be decreased when combined with Esomeprazole.
Alpelisib Alpelisib The serum concentration of Alpelisib can be decreased when it is combined with Primidone.
Brexanolone Injection Brexanolone Injection The risk or severity of adverse effects can be increased when Primidone is combined with Brexanolone.
Polatuzumab vedotin-piiq Injection Polatuzumab vedotin-piiq Injection The risk or severity of adverse effects can be decreased when Primidone is combined with Polatuzumab vedotin.
Solriamfetol Solriamfetol The risk or severity of adverse effects can be increased when Primidone is combined with Solriamfetol.
Darolutamide Darolutamide The serum concentration of Darolutamide can be decreased when it is combined with Primidone.
Triclabendazole Triclabendazole The metabolism of Primidone can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The metabolism of Entrectinib can be increased when combined with Primidone.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be increased when combined with Primidone.
Upadacitinib Upadacitinib The metabolism of Upadacitinib can be increased when combined with Primidone.
Istradefylline Istradefylline The metabolism of Istradefylline can be increased when combined with Primidone.
Pitolisant Pitolisant The metabolism of Pitolisant can be increased when combined with Primidone.
Fedratinib Fedratinib The metabolism of Fedratinib can be decreased when combined with Primidone.
Lefamulin Lefamulin The metabolism of Lefamulin can be increased when combined with Primidone.
Phenytoin Injection Phenytoin Injection The metabolism of Primidone can be increased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Primidone can be increased when combined with Fosphenytoin.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be increased when combined with Primidone.
Voxelotor Voxelotor The serum concentration of Voxelotor can be decreased when it is combined with Primidone.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Primidone.
Lumateperone Lumateperone The serum concentration of Lumateperone can be decreased when it is combined with Primidone.
Lasmiditan Lasmiditan The risk or severity of adverse effects can be increased when Primidone is combined with Lasmiditan.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be decreased when it is combined with Primidone.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be increased when combined with Primidone.
Cenobamate Cenobamate The serum concentration of Primidone can be increased when it is combined with Cenobamate.
Pemigatinib Pemigatinib The metabolism of Pemigatinib can be increased when combined with Primidone.
Selumetinib Selumetinib The serum concentration of Selumetinib can be decreased when it is combined with Primidone.
Rimegepant Rimegepant The metabolism of Rimegepant can be increased when combined with Primidone.
Tucatinib Tucatinib The metabolism of Tucatinib can be increased when combined with Primidone.
Sacituzumab govitecan-hziy Injection Sacituzumab govitecan-hziy Injection The serum concentration of Sacituzumab govitecan can be decreased when it is combined with Primidone.
Ripretinib Ripretinib The serum concentration of Ripretinib can be decreased when it is combined with Primidone.
Selpercatinib Selpercatinib The serum concentration of Selpercatinib can be decreased when it is combined with Primidone.
Capmatinib Capmatinib The serum concentration of Capmatinib can be decreased when it is combined with Primidone.
Lemborexant Lemborexant The serum concentration of Lemborexant can be decreased when it is combined with Primidone.
Fenfluramine Fenfluramine The serum concentration of Primidone can be decreased when it is combined with Fenfluramine.
Fostemsavir Fostemsavir The serum concentration of Fostemsavir can be decreased when it is combined with Primidone.
Lurbinectedin Injection Lurbinectedin Injection The serum concentration of Lurbinectedin can be decreased when it is combined with Primidone.
Pralsetinib Pralsetinib The serum concentration of Primidone can be decreased when it is combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Primidone can be decreased when it is combined with Satralizumab.
Relugolix Relugolix The serum concentration of Relugolix can be decreased when it is combined with Primidone.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be increased when combined with Primidone.
Viloxazine Viloxazine The risk or severity of adverse effects can be increased when Primidone is combined with Viloxazine.
Theophylline Theophylline The metabolism of Theophylline can be increased when combined with Primidone.
Indomethacin Indomethacin The metabolism of Indomethacin can be increased when combined with Primidone.
Mefenamic Acid Mefenamic Acid The metabolism of Primidone can be decreased when combined with Mefenamic acid.
Naproxen Naproxen The metabolism of Naproxen can be increased when combined with Primidone.
Trazodone Trazodone The serum concentration of Trazodone can be decreased when it is combined with Primidone.
Floxuridine Floxuridine The metabolism of Primidone can be decreased when combined with Floxuridine.
Phenobarbital Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Primidone.
Metaxalone Metaxalone The risk or severity of adverse effects can be increased when Metaxalone is combined with Primidone.
Methotrexate Injection Methotrexate Injection The metabolism of Methotrexate can be increased when combined with Primidone.
Levorphanol Levorphanol The risk or severity of adverse effects can be increased when Primidone is combined with Levorphanol.
Methsuximide Methsuximide The risk or severity of adverse effects can be increased when Primidone is combined with Methsuximide.
Diethylpropion Diethylpropion The serum concentration of Primidone can be decreased when it is combined with Diethylpropion.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be increased when combined with Primidone.
Diazepam Diazepam The metabolism of Primidone can be decreased when combined with Diazepam.
Oxazepam Oxazepam The risk or severity of adverse effects can be increased when Primidone is combined with Oxazepam.
Flurazepam Flurazepam The risk or severity of adverse effects can be increased when Flurazepam is combined with Primidone.
Clorazepate Clorazepate The risk or severity of adverse effects can be increased when Clorazepic acid is combined with Primidone.
Lorazepam Lorazepam The metabolism of Lorazepam can be increased when combined with Primidone.
Phenoxybenzamine Phenoxybenzamine Primidone may increase the hypotensive activities of Phenoxybenzamine.
Carmustine Carmustine The metabolism of Carmustine can be increased when combined with Primidone.
Amantadine Amantadine The risk or severity of adverse effects can be increased when Primidone is combined with Amantadine.
Codeine Codeine The risk or severity of adverse effects can be increased when Primidone is combined with Codeine.
Meprobamate Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Primidone.
Chlordiazepoxide Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Primidone.
Bromocriptine Bromocriptine The risk or severity of adverse effects can be increased when Primidone is combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Primidone can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Primidone can be decreased when combined with Phenelzine.
Procarbazine Procarbazine The risk or severity of adverse effects can be increased when Primidone is combined with Procarbazine.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of adverse effects can be increased when Primidone is combined with Ergoloid mesylate.
Minocycline Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Primidone.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be increased when combined with Primidone.
Thioridazine Thioridazine The risk or severity of adverse effects can be increased when Thioridazine is combined with Primidone.
Trifluoperazine Trifluoperazine The metabolism of Trifluoperazine can be increased when combined with Primidone.
Dapsone Dapsone The metabolism of Primidone can be decreased when combined with Dapsone.
Sulfadiazine Sulfadiazine The metabolism of Primidone can be decreased when combined with Sulfadiazine.
Oxycodone Oxycodone The risk or severity of adverse effects can be increased when Primidone is combined with Oxycodone.
Methadone Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Primidone.
Oxybutynin Oxybutynin Primidone may increase the central nervous system depressant (CNS depressant) activities of Oxybutynin.
Benztropine Benztropine Primidone may increase the central nervous system depressant (CNS depressant) activities of Benzatropine.
Maprotiline Maprotiline The metabolism of Maprotiline can be increased when combined with Primidone.
Ibuprofen Ibuprofen The metabolism of Ibuprofen can be increased when combined with Primidone.
Trihexyphenidyl Trihexyphenidyl Primidone may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine Orphenadrine Primidone may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Perphenazine Perphenazine The metabolism of Perphenazine can be increased when combined with Primidone.
Azathioprine Azathioprine The metabolism of Azathioprine can be increased when combined with Primidone.
Fluphenazine Fluphenazine The risk or severity of adverse effects can be increased when Fluphenazine is combined with Primidone.
Phentermine Phentermine The serum concentration of Primidone can be decreased when it is combined with Phentermine.
Methylphenidate Methylphenidate The serum concentration of Primidone can be increased when it is combined with Methylphenidate.
Amoxapine Amoxapine The metabolism of Amoxapine can be increased when combined with Primidone.
Doxorubicin Doxorubicin The metabolism of Doxorubicin can be increased when combined with Primidone.
Mechlorethamine Mechlorethamine The therapeutic efficacy of Primidone can be decreased when used in combination with Mechlorethamine.
Pyridostigmine Pyridostigmine The therapeutic efficacy of Primidone can be decreased when used in combination with Pyridostigmine.
Carbamazepine Carbamazepine Carbamazepine may increase the Change in thyroid function activities of Primidone.
Molindone Molindone The risk or severity of adverse effects can be increased when Primidone is combined with Molindone.
Methyldopa Methyldopa Primidone may increase the hypotensive activities of Methyldopa.
Clonidine Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Primidone.
Prazosin Prazosin Primidone may increase the hypotensive activities of Prazosin.
Hydralazine Hydralazine Primidone may increase the hypotensive activities of Hydralazine.
Cimetidine Cimetidine The metabolism of Primidone can be decreased when combined with Cimetidine.
Warfarin Warfarin The metabolism of Warfarin can be increased when combined with Primidone.
Clonazepam Clonazepam The metabolism of Clonazepam can be increased when combined with Primidone.
Loperamide Loperamide The metabolism of Loperamide can be increased when combined with Primidone.
Promethazine Promethazine The metabolism of Primidone can be decreased when combined with Promethazine.
Griseofulvin Griseofulvin The serum concentration of Griseofulvin can be decreased when it is combined with Primidone.
Loxapine Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Primidone.
Chloroquine Chloroquine The therapeutic efficacy of Primidone can be decreased when used in combination with Chloroquine.
Quinine Quinine The serum concentration of Primidone can be increased when it is combined with Quinine.
Ethosuximide Ethosuximide The risk or severity of adverse effects can be increased when Ethosuximide is combined with Primidone.
Triamterene Triamterene The metabolism of Triamterene can be increased when combined with Primidone.
Lactulose Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Primidone.
Sulfinpyrazone Sulfinpyrazone The metabolism of Primidone can be decreased when combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide The risk or severity of hypotension and orthostatic hypotension can be increased when Primidone is combined with Chlorothiazide.
Chlorthalidone Chlorthalidone The risk or severity of hypotension and orthostatic hypotension can be increased when Primidone is combined with Chlorthalidone.
Metolazone Metolazone The risk or severity of hypotension and orthostatic hypotension can be increased when Primidone is combined with Metolazone.
Isosorbide Isosorbide The metabolism of Isosorbide can be increased when combined with Primidone.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be increased when combined with Primidone.
Secobarbital Secobarbital The risk or severity of adverse effects can be increased when Primidone is combined with Secobarbital.
Desipramine Desipramine The metabolism of Desipramine can be increased when combined with Primidone.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be increased when combined with Primidone.
Imipramine Imipramine The metabolism of Imipramine can be increased when combined with Primidone.
Probenecid Probenecid The metabolism of Primidone can be decreased when combined with Probenecid.
Quinidine Quinidine The serum concentration of Primidone can be increased when it is combined with Quinidine.
Procainamide Procainamide The therapeutic efficacy of Primidone can be decreased when used in combination with Procainamide.
Isoniazid Isoniazid The metabolism of Primidone can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Rifampicin can be increased when combined with Primidone.
Disopyramide Disopyramide The metabolism of Disopyramide can be increased when combined with Primidone.
Valproic Acid Valproic Acid The serum concentration of Phenobarbital, an active metabolite of Primidone, can be increased when used in combination with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Primidone can be increased when combined with Tamoxifen.
Butabarbital Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Primidone.
Levothyroxine Levothyroxine The metabolism of Levothyroxine can be increased when combined with Primidone.
Liothyronine Liothyronine The metabolism of Liothyronine can be increased when combined with Primidone.
Methimazole Methimazole The metabolism of Primidone can be decreased when combined with Methimazole.
Chlorpropamide Chlorpropamide The metabolism of Primidone can be decreased when combined with Chlorpropamide.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Primidone.
Tolazamide Tolazamide The metabolism of Tolazamide can be decreased when combined with Primidone.
Dextromethorphan Dextromethorphan The risk or severity of adverse effects can be increased when Dextromethorphan is combined with Primidone.
Cyclobenzaprine Cyclobenzaprine The risk or severity of CNS depression can be increased when Primidone is combined with Cyclobenzaprine.
Niacin Niacin The metabolism of Primidone can be decreased when combined with Niacin.
Baclofen Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Primidone.
Doxylamine Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Primidone.
Cyproheptadine Cyproheptadine Primidone may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.
Clemastine Clemastine The risk or severity of adverse effects can be increased when Clemastine is combined with Primidone.
Chlorpheniramine Chlorpheniramine The risk or severity of adverse effects can be increased when Primidone is combined with Chlorpheniramine.
Brompheniramine Brompheniramine The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Primidone.
Meclizine Meclizine The risk or severity of adverse effects can be increased when Meclizine is combined with Primidone.
Methyclothiazide Methyclothiazide The risk or severity of hypotension and orthostatic hypotension can be increased when Primidone is combined with Methyclothiazide.
Hydrochlorothiazide Hydrochlorothiazide The risk or severity of hypotension and orthostatic hypotension can be increased when Primidone is combined with Hydrochlorothiazide.
Dantrolene Dantrolene The risk or severity of adverse effects can be increased when Primidone is combined with Dantrolene.
Chlorzoxazone Chlorzoxazone The metabolism of Chlorzoxazone can be increased when combined with Primidone.
Carisoprodol Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Primidone.
Methocarbamol Methocarbamol The risk or severity of adverse effects can be increased when Methocarbamol is combined with Primidone.
Pyridoxine Pyridoxine The metabolism of Primidone can be increased when combined with Pyridoxine.
Folic Acid Folic Acid The serum concentration of Primidone can be decreased when it is combined with Folic acid.
Disulfiram Disulfiram The therapeutic efficacy of Primidone can be decreased when used in combination with Disulfiram.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The serum concentration of Propranolol can be decreased when it is combined with Primidone.
Minoxidil Minoxidil The metabolism of Minoxidil can be increased when combined with Primidone.
Pseudoephedrine Pseudoephedrine The serum concentration of Primidone can be decreased when it is combined with Pseudoephedrine.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be increased when combined with Primidone.
Spironolactone Spironolactone Primidone may increase the hypotensive activities of Spironolactone.
Amphotericin B Injection Amphotericin B Injection Primidone may increase the hypotensive activities of Amphotericin B.
Mercaptopurine Mercaptopurine The serum concentration of Mercaptopurine can be decreased when it is combined with Primidone.
Nadolol Nadolol The serum concentration of Nadolol can be decreased when it is combined with Primidone.
Butorphanol Injection Butorphanol Injection The risk or severity of adverse effects can be increased when Butorphanol is combined with Primidone.
Nalbuphine Injection Nalbuphine Injection The risk or severity of adverse effects can be increased when Primidone is combined with Nalbuphine.
Cholestyramine Resin Cholestyramine Resin Cholestyramine can cause a decrease in the absorption of Primidone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Trimethobenzamide Trimethobenzamide The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Primidone.
Flavoxate Flavoxate Primidone may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
Papaverine Papaverine Primidone may increase the hypotensive activities of Papaverine.
Fluorouracil Injection Fluorouracil Injection The metabolism of Primidone can be increased when combined with Fluorouracil.
Colchicine Colchicine The metabolism of Primidone can be increased when combined with Colchicine.
Cephalexin Cephalexin The metabolism of Cephalexin can be increased when combined with Primidone.
Dacarbazine Dacarbazine The metabolism of Dacarbazine can be increased when combined with Primidone.
Acetazolamide Acetazolamide The serum concentration of Primidone can be decreased when it is combined with Acetazolamide.
Cefotaxime Injection Cefotaxime Injection The therapeutic efficacy of Primidone can be decreased when used in combination with Cefotaxime.
Ketoconazole Ketoconazole The metabolism of Primidone can be decreased when combined with Ketoconazole.
Pyrantel Pyrantel The risk or severity of adverse effects can be increased when Primidone is combined with Pyrantel.
Thiotepa Injection Thiotepa Injection The metabolism of Primidone can be increased when combined with Thiotepa.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be increased when combined with Primidone.
Captopril Captopril Primidone may increase the hypotensive activities of Captopril.
Dipyridamole Dipyridamole Primidone may increase the hypotensive activities of Dipyridamole.
Isoxsuprine Isoxsuprine Primidone may increase the hypotensive activities of Isoxsuprine.
Vinblastine Vinblastine The metabolism of Vinblastine can be increased when combined with Primidone.
Ethacrynic Acid Ethacrynic Acid Primidone may increase the hypotensive activities of Etacrynic acid.
Metoprolol Metoprolol The metabolism of Metoprolol can be increased when combined with Primidone.
Hydroxyzine Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Primidone.
Thiothixene Thiothixene The metabolism of Thiothixene can be increased when combined with Primidone.
Aspirin Aspirin The metabolism of Acetylsalicylic acid can be decreased when combined with Primidone.
Chlorambucil Chlorambucil The therapeutic efficacy of Primidone can be decreased when used in combination with Chlorambucil.
Alprazolam Alprazolam The risk or severity of adverse effects can be increased when Alprazolam is combined with Primidone.
Temazepam Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Primidone.
Triazolam Triazolam The risk or severity of adverse effects can be increased when Primidone is combined with Triazolam.
Dicyclomine Dicyclomine Primidone may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
Hyoscyamine Hyoscyamine Primidone may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
Propantheline Propantheline Primidone may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
Trimethoprim Trimethoprim The metabolism of Primidone can be decreased when combined with Trimethoprim.
Diltiazem Diltiazem The metabolism of Primidone can be increased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Nifedipine can be increased when combined with Primidone.
Timolol Timolol The serum concentration of Timolol can be decreased when it is combined with Primidone.
Verapamil Verapamil The metabolism of Primidone can be increased when combined with Verapamil.
Atenolol Atenolol The serum concentration of Atenolol can be decreased when it is combined with Primidone.
Pindolol Pindolol The serum concentration of Pindolol can be decreased when it is combined with Primidone.
Cisplatin Injection Cisplatin Injection The metabolism of Primidone can be decreased when combined with Cisplatin.
Piroxicam Piroxicam The metabolism of Primidone can be decreased when combined with Piroxicam.
Bumetanide Bumetanide Primidone may increase the hypotensive activities of Bumetanide.
Streptozocin Streptozocin The metabolism of Primidone can be increased when combined with Streptozocin.
Etoposide Etoposide The metabolism of Etoposide can be increased when combined with Primidone.
Glyburide Glyburide The metabolism of Primidone can be decreased when combined with Glyburide.
Glipizide Glipizide The metabolism of Glipizide can be increased when combined with Primidone.
Indapamide Indapamide The risk or severity of hypotension and orthostatic hypotension can be increased when Primidone is combined with Indapamide.
Pentoxifylline Pentoxifylline The metabolism of Pentoxifylline can be increased when combined with Primidone.
Labetalol Labetalol The serum concentration of Labetalol can be decreased when it is combined with Primidone.
Gemfibrozil Gemfibrozil The metabolism of Primidone can be decreased when combined with Gemfibrozil.
Guanabenz Guanabenz The metabolism of Guanabenz can be increased when combined with Primidone.
Ketoprofen Ketoprofen The metabolism of Ketoprofen can be increased when combined with Primidone.
Pimozide Pimozide The metabolism of Pimozide can be increased when combined with Primidone.
Enalapril Enalapril Primidone may increase the hypotensive activities of Enalapril.
Flurbiprofen Flurbiprofen The metabolism of Flurbiprofen can be increased when combined with Primidone.
Amiodarone Amiodarone The metabolism of Amiodarone can be increased when combined with Primidone.
Lovastatin Lovastatin The metabolism of Primidone can be decreased when combined with Lovastatin.
Diclofenac Diclofenac The metabolism of Primidone can be increased when combined with Diclofenac.
Fluoxetine Fluoxetine Primidone may increase the central nervous system depressant (CNS depressant) activities of Fluoxetine.
Nimodipine Nimodipine The metabolism of Nimodipine can be increased when combined with Primidone.
Clozapine Clozapine The metabolism of Primidone can be increased when combined with Clozapine.
Estazolam Estazolam The risk or severity of adverse effects can be increased when Primidone is combined with Estazolam.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Primidone.
Benazepril Benazepril Primidone may increase the hypotensive activities of Benazepril.
Etodolac Etodolac The metabolism of Primidone can be decreased when combined with Etodolac.
Felodipine Felodipine The metabolism of Primidone can be decreased when combined with Felodipine.
Fosinopril Fosinopril Primidone may increase the hypotensive activities of Fosinopril.
Nabumetone Nabumetone The metabolism of Nabumetone can be increased when combined with Primidone.
Quinapril Quinapril Primidone may increase the hypotensive activities of Quinapril.
Ramipril Ramipril Ramipril may increase the hypotensive activities of Primidone.
Simvastatin Simvastatin The metabolism of Primidone can be decreased when combined with Simvastatin.
Amlodipine Amlodipine The metabolism of Amlodipine can be increased when combined with Primidone.
Teniposide Injection Teniposide Injection The serum concentration of Teniposide can be decreased when it is combined with Primidone.
Itraconazole Itraconazole The metabolism of Primidone can be decreased when combined with Itraconazole.
Lisinopril Lisinopril Primidone may increase the hypotensive activities of Lisinopril.
Atovaquone Atovaquone The metabolism of Primidone can be decreased when combined with Atovaquone.
Rifabutin Rifabutin The metabolism of Primidone can be increased when combined with Rifabutin.
Sotalol Sotalol The serum concentration of Sotalol can be decreased when it is combined with Primidone.
Bisoprolol Bisoprolol Primidone may increase the hypotensive activities of Bisoprolol.
Zolpidem Zolpidem Primidone may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin Doxazosin The metabolism of Doxazosin can be increased when combined with Primidone.
Terazosin Terazosin Primidone may increase the hypotensive activities of Terazosin.
Isradipine Isradipine The metabolism of Isradipine can be increased when combined with Primidone.
Omeprazole Omeprazole The metabolism of Primidone can be decreased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Cisapride can be increased when combined with Primidone.
Gabapentin Gabapentin The risk or severity of adverse effects can be increased when Primidone is combined with Gabapentin.
Fluvastatin Fluvastatin The metabolism of Primidone can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The risk or severity of adverse effects can be increased when Venlafaxine is combined with Primidone.
Nizatidine Nizatidine The therapeutic efficacy of Primidone can be decreased when used in combination with Nizatidine.
Famciclovir Famciclovir The metabolism of Famciclovir can be increased when combined with Primidone.
Fluvoxamine Fluvoxamine The metabolism of Fluvoxamine can be decreased when combined with Primidone.
Nefazodone Nefazodone The risk or severity of adverse effects can be increased when Primidone is combined with Nefazodone.
Lamotrigine Lamotrigine Primidone may increase the excretion rate of Lamotrigine which could result in a lower serum level and potentially a reduction in efficacy.
Losartan Losartan The metabolism of Primidone can be decreased when combined with Losartan.
Tramadol Tramadol The metabolism of Tramadol can be increased when combined with Primidone.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be increased when combined with Primidone.
Moexipril Moexipril Primidone may increase the hypotensive activities of Moexipril.
Lansoprazole Lansoprazole The metabolism of Primidone can be decreased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be increased when combined with Primidone.
Nicardipine Nicardipine The metabolism of Primidone can be decreased when combined with Nicardipine.
Bupropion Bupropion The risk or severity of adverse effects can be increased when Primidone is combined with Bupropion.
Ticlopidine Ticlopidine The metabolism of Primidone can be decreased when combined with Ticlopidine.
Nisoldipine Nisoldipine Primidone may increase the hypotensive activities of Nisoldipine.
Riluzole Riluzole The metabolism of Riluzole can be increased when combined with Primidone.
Amifostine Injection Amifostine Injection Primidone may increase the hypotensive activities of Amifostine.
Glimepiride Glimepiride The metabolism of Primidone can be decreased when combined with Glimepiride.
Ritonavir Ritonavir The metabolism of Primidone can be decreased when combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be increased when combined with Primidone.
Clomipramine Clomipramine The metabolism of Clomipramine can be increased when combined with Primidone.
Zafirlukast Zafirlukast The metabolism of Zafirlukast can be decreased when combined with Primidone.
Mirtazapine Mirtazapine Primidone may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Trandolapril Trandolapril Primidone may increase the hypotensive activities of Trandolapril.
Topiramate Topiramate The metabolism of Topiramate can be decreased when combined with Primidone.
Zileuton Zileuton The metabolism of Primidone can be increased when combined with Zileuton.
Valsartan Valsartan Primidone may increase the hypotensive activities of Valsartan.
Pramipexole Pramipexole Primidone may increase the sedative activities of Pramipexole.
Donepezil Donepezil The therapeutic efficacy of Donepezil can be decreased when used in combination with Primidone.
Nelfinavir Nelfinavir The metabolism of Primidone can be decreased when combined with Nelfinavir.
Azithromycin Azithromycin The metabolism of Azithromycin can be increased when combined with Primidone.
Loratadine Loratadine Primidone may increase the anticholinergic activities of Loratadine.
Carvedilol Carvedilol The metabolism of Carvedilol can be increased when combined with Primidone.
Nilutamide Nilutamide The metabolism of Primidone can be decreased when combined with Nilutamide.
Flutamide Flutamide The metabolism of Flutamide can be increased when combined with Primidone.
Selegiline Selegiline The metabolism of Selegiline can be increased when combined with Primidone.
Bicalutamide Bicalutamide The metabolism of Primidone can be increased when combined with Bicalutamide.
Sertraline Sertraline The risk or severity of adverse effects can be increased when Primidone is combined with Sertraline.
Propafenone Propafenone The metabolism of Propafenone can be increased when combined with Primidone.
Letrozole Letrozole The metabolism of Primidone can be decreased when combined with Letrozole.
Raloxifene Raloxifene The metabolism of Raloxifene can be increased when combined with Primidone.
Irbesartan Irbesartan Primidone may increase the hypotensive activities of Irbesartan.
Tamsulosin Tamsulosin Primidone may increase the hypotensive activities of Tamsulosin.
Ropinirole Ropinirole The metabolism of Ropinirole can be increased when combined with Primidone.
Quetiapine Quetiapine The metabolism of Quetiapine can be increased when combined with Primidone.
Cetirizine Cetirizine The risk or severity of adverse effects can be increased when Cetirizine is combined with Primidone.
Paroxetine Paroxetine The metabolism of Paroxetine can be increased when combined with Primidone.
Tolcapone Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Primidone.
Citalopram Citalopram The risk or severity of adverse effects can be increased when Primidone is combined with Citalopram.
Capecitabine Capecitabine The metabolism of Primidone can be decreased when combined with Capecitabine.
Efavirenz Efavirenz The metabolism of Primidone can be increased when combined with Efavirenz.
Abacavir Abacavir The metabolism of Abacavir can be increased when combined with Primidone.
Sildenafil Sildenafil The metabolism of Primidone can be decreased when combined with Sildenafil.
Celecoxib Celecoxib The metabolism of Primidone can be decreased when combined with Celecoxib.
Rosiglitazone Rosiglitazone The metabolism of Primidone can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine Primidone may increase the central nervous system depressant (CNS depressant) activities of Tolterodine.
Thalidomide Thalidomide Primidone may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Nateglinide Nateglinide The metabolism of Primidone can be decreased when combined with Nateglinide.
Galantamine Galantamine The therapeutic efficacy of Primidone can be decreased when used in combination with Galantamine.
Levetiracetam Levetiracetam The risk or severity of adverse effects can be increased when Primidone is combined with Levetiracetam.
Rabeprazole Rabeprazole The metabolism of Primidone can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Terbinafine can be increased when combined with Primidone.

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