Leflunomide
Generic name: Pronounced as (le floo' na mide)
Medical Content Reviewed By HelloPharmacist Staff
Last Revised - 08/15/2015
On this page
- Why is this medication prescribed?
- How should this medicine be used?
- Other uses for this medicine
- What special precautions should I follow?
- What should I do if I forget a dose?
- What side effects can this medication cause?
- What should I know about STORAGE and DISPOSAL of this medication?
- What should I do in case of OVERDOSE?
- What OTHER INFORMATION should I know?
- Drug interactions
IMPORTANT WARNING
Do not take leflunomide if you are pregnant or plan to become pregnant. Leflunomide may harm the fetus. You should not begin taking leflunomide until you have taken a pregnancy test with negative results and your doctor tells you that you are not pregnant. You must use an effective method of birth control before you begin taking leflunomide, during your treatment with leflunomide, and for 2 years after treatment. If your period is late or you miss a period during treatment with leflunomide, call your doctor immediately. Talk to your doctor if you plan to become pregnant within 2 years after stopping treatment with leflunomide. Your doctor can prescribe a treatment that will help to remove this medication more quickly from your body.
Leflunomide may cause liver damage that can be life-threatening and even cause death. The risk for liver damage is greatest in people taking other medications known to cause liver damage, and in people who already have liver disease. Tell your doctor if you have or have ever had hepatitis or any other type of liver disease and if you if you drink or have ever drunk large amounts of alcohol. Tell your doctor and pharmacist if you are taking acetaminophen (Tylenol, in other over-the-counter products), aspirin and other nonsteroidal anti-inflammatory medications (NSAIDs such as ibuprofen [Advil, Motrin] and naproxen [Aleve, Naprosyn], cholesterol-lowering medications (statins), hydroxychloroquine, iron products, isoniazid (Laniazid, in Rifamate, in Rifater), methotrexate (Trexall), niacin (nicotinic acid), or rifampin (Rifadin, Rimactane, in Rifamate, in Rifater). If you experience any of the following symptoms, call your doctor immediately: nausea, extreme tiredness, unusual bleeding or bruising, lack of energy, loss of appetite, pain in the upper right part of the stomach, yellowing of the skin or eyes, dark-colored urine, or flu-like symptoms.
Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to leflunomide.
Talk to your doctor about the risks of taking leflunomide.
Why is this medication prescribed?
Leflunomide is used alone or in combination with other medications to treat rheumatoid arthritis (a condition in which the body attacks its own joints, causing pain, swelling, and loss of function). Leflunomide is in a class of medications called disease-modifying antirheumatic drugs (DMARDs). It works by decreasing inflammation and slowing the progress of the condition, which can help improve the physical activity of people with rheumatoid arthritis.
How should this medicine be used?
Leflunomide comes as a tablet to take by mouth. It is usually taken once a day. Your doctor may tell you to take a larger dose of leflunomide for the first 3 days of treatment. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take leflunomide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Your doctor may need to decrease your dose or stop treatment if you experience certain severe side effects. Be sure to tell your doctor how you are feeling during your treatment.
Leflunomide may help control the symptoms of your rheumatoid arthritis but does not cure it. Continue to take leflunomide even if you feel well. Do not stop taking leflunomide without talking to your doctor.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking leflunomide,
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tell your doctor and pharmacist if you are allergic to leflunomide, teriflunomide (Aubagio), any other medications, or any of the ingredients in leflunomide tablets. Ask your pharmacist for a list of the ingredients.
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tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin Jantoven); cholestyramine (Prevalite); gold compounds such as auranofin (Ridaura); medications to treat cancer; other medications that suppress the immune system such as azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), and tacrolimus (Astagraf, Prograf); penicillamine (Cuprimine, Depen), and tolbutamide. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
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tell your doctor if you have or have ever had serious infections or if you frequently get infections, cancer or other conditions affecting the bone marrow or the immune system (including human immunodeficiency virus [HIV] and acquired immunodeficiency syndrome [AIDS]), diabetes, or kidney disease.
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tell your doctor if you are breastfeeding. Do not breastfeed while you are taking leflunomide.
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if you are planning to father a child, you should talk to your doctor about stopping leflunomide and receiving a treatment to help to remove this medication from your body more quickly.
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ask your doctor about the safe use of alcoholic beverages while you are taking leflunomide.
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Taking leflunomide may decrease your ability to fight infection. Tell your doctor if you have an infection now or if you have any signs of infection such as fever, cough, or flu-like symptoms. If you experience any of the following symptoms during your treatment with leflunomide, call your doctor: fever; sore throat; cough; flu-like symptoms; area of warm, red, swollen, or painful skin; painful, difficult, or frequent urination; or other signs of infection. Your treatment with leflunomide may need to be interrupted if you have an infection.
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You may already be infected with tuberculosis (TB; a serious lung infection) but not have any symptoms of the disease. In this case, leflunomide may make your infection more serious and cause you to develop symptoms. Tell your doctor if you have or have ever had TB, if you have lived in or visited a country where TB is common, or if you have been around someone who has or has ever had TB. Before you begin your treatment with leflunomide, your doctor will perform a skin test to see if you have TB. If you do have TB, your doctor will treat this infection with antibiotics before you begin taking leflunomide.
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do not have any vaccinations without talking to your doctor.
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you should know that leflunomide may cause high blood pressure. You should have your blood pressure checked before starting treatment and regularly while you are taking this medication.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
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Leflunomide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
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diarrhea
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vomiting
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heartburn
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headache
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dizziness
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weight loss
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back pain
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muscle pain or weakness
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pain, burning, numbness, or tingling in the hands or feet
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hair loss
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leg cramps
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dry skin
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Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS section, call your doctor immediately or get emergency medical treatment:
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rash with or without a fever
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hives
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blisters or peeling of skin
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mouth sores
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itching
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difficulty breathing
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new or worsening cough
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chest pain
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pale skin
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Receiving medications which suppress the immune system may increase the risk of developing certain types of cancer. An increase in cancers was not reported in clinical studies with leflunomide to date. Talk to your doctor about the risks of receiving leflunomide.
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Leflunomide may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
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If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I know about STORAGE and DISPOSAL of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom) and light.
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Symptoms of overdose may include the following:
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diarrhea
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stomach pain
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extreme tiredness
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weakness
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pale skin
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fast heartbeat
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shortness of breath
What OTHER INFORMATION should I know?
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Drug interactions
Drug | Interaction |
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Moxifloxacin | Moxifloxacin The metabolism of Leflunomide can be decreased when combined with Moxifloxacin. |
Repaglinide | Repaglinide The serum concentration of Repaglinide can be increased when it is combined with Leflunomide. |
Montelukast | Montelukast The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Leflunomide. |
Insulin Glargine (rDNA origin) Injection | Insulin Glargine (rDNA origin) Injection The metabolism of Leflunomide can be increased when combined with Insulin glargine. |
Delavirdine | Delavirdine The metabolism of Leflunomide can be decreased when combined with Delavirdine. |
Nevirapine | Nevirapine The metabolism of Leflunomide can be decreased when combined with Nevirapine. |
Atorvastatin | Atorvastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Atorvastatin is combined with Leflunomide. |
Alendronate | Alendronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Alendronic acid is combined with Leflunomide. |
Aminophylline | Aminophylline The serum concentration of Aminophylline can be decreased when it is combined with Leflunomide. |
Anagrelide | Anagrelide The serum concentration of Anagrelide can be decreased when it is combined with Leflunomide. |
Candesartan | Candesartan The metabolism of Candesartan can be decreased when combined with Leflunomide. |
Cilostazol | Cilostazol The serum concentration of Cilostazol can be decreased when it is combined with Leflunomide. |
Clopidogrel | Clopidogrel The serum concentration of Clopidogrel can be decreased when it is combined with Leflunomide. |
Estrogen and Progestin (Oral Contraceptives) | Estrogen and Progestin (Oral Contraceptives) The serum concentration of Conjugated estrogens can be decreased when it is combined with Leflunomide. |
Fenofibrate | Fenofibrate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Fenofibrate is combined with Leflunomide. |
Mycophenolate | Mycophenolate The risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Leflunomide. |
Nafarelin | Nafarelin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Nafarelin is combined with Leflunomide. |
Prednisone | Prednisone The risk or severity of adverse effects can be increased when Prednisone is combined with Leflunomide. |
Ranitidine | Ranitidine The serum concentration of Ranitidine can be decreased when it is combined with Leflunomide. |
Tacrolimus | Tacrolimus Tacrolimus may increase the immunosuppressive activities of Leflunomide. |
Tizanidine | Tizanidine The serum concentration of Tizanidine can be decreased when it is combined with Leflunomide. |
Triamcinolone | Triamcinolone The risk or severity of adverse effects can be increased when Triamcinolone is combined with Leflunomide. |
Zolmitriptan | Zolmitriptan The serum concentration of Zolmitriptan can be decreased when it is combined with Leflunomide. |
Famotidine Injection | Famotidine Injection The metabolism of Leflunomide can be decreased when combined with Famotidine. |
Fluconazole Injection | Fluconazole Injection The metabolism of Leflunomide can be decreased when combined with Fluconazole. |
Hydromorphone Injection | Hydromorphone Injection The metabolism of Hydromorphone can be decreased when combined with Leflunomide. |
Interferon Beta-1b Injection | Interferon Beta-1b Injection The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Leflunomide. |
Interferon Gamma-1b Injection | Interferon Gamma-1b Injection The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Leflunomide. |
Levofloxacin Injection | Levofloxacin Injection The metabolism of Leflunomide can be decreased when combined with Levofloxacin. |
Meperidine Injection | Meperidine Injection The metabolism of Leflunomide can be increased when combined with Meperidine. |
Methylprednisolone Injection | Methylprednisolone Injection The risk or severity of adverse effects can be increased when Methylprednisolone is combined with Leflunomide. |
Metoclopramide Injection | Metoclopramide Injection The serum concentration of Metoclopramide can be decreased when it is combined with Leflunomide. |
Metronidazole Injection | Metronidazole Injection The metabolism of Leflunomide can be decreased when combined with Metronidazole. |
Pamidronate Injection | Pamidronate Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pamidronic acid is combined with Leflunomide. |
Zidovudine Injection | Zidovudine Injection The risk or severity of adverse effects can be increased when Zidovudine is combined with Leflunomide. |
Cyclosporine | Cyclosporine Leflunomide may increase the immunosuppressive activities of Cyclosporine. |
Ondansetron | Ondansetron The metabolism of Leflunomide can be decreased when combined with Ondansetron. |
Torsemide | Torsemide The metabolism of Leflunomide can be decreased when combined with Torasemide. |
Olanzapine | Olanzapine The serum concentration of Olanzapine can be decreased when it is combined with Leflunomide. |
Alosetron | Alosetron The serum concentration of Alosetron can be decreased when it is combined with Leflunomide. |
Eprosartan | Eprosartan The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Eprosartan is combined with Leflunomide. |
Hydroxychloroquine | Hydroxychloroquine The risk or severity of adverse effects can be increased when Hydroxychloroquine is combined with Leflunomide. |
Meloxicam | Meloxicam The metabolism of Meloxicam can be decreased when combined with Leflunomide. |
Pantoprazole | Pantoprazole Pantoprazole may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Risedronate | Risedronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Risedronic acid is combined with Leflunomide. |
Sevelamer | Sevelamer Sevelamer may increase the excretion rate of Leflunomide which could result in a lower serum level and potentially a reduction in efficacy. |
Telmisartan | Telmisartan Telmisartan may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Temozolomide | Temozolomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Leflunomide. |
Anakinra | Anakinra The risk or severity of adverse effects can be increased when Anakinra is combined with Leflunomide. |
Linezolid | Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Leflunomide. |
Trimipramine | Trimipramine The metabolism of Trimipramine can be decreased when combined with Leflunomide. |
Etanercept Injection | Etanercept Injection The risk or severity of adverse effects can be increased when Etanercept is combined with Leflunomide. |
Modafinil | Modafinil The metabolism of Leflunomide can be decreased when combined with Modafinil. |
Sirolimus | Sirolimus The risk or severity of adverse effects can be increased when Sirolimus is combined with Leflunomide. |
Epinephrine Injection | Epinephrine Injection The metabolism of Leflunomide can be decreased when combined with Epinephrine. |
Epirubicin | Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Leflunomide. |
Adalimumab Injection | Adalimumab Injection The risk or severity of adverse effects can be increased when Adalimumab is combined with Leflunomide. |
Glatiramer Injection | Glatiramer Injection The risk or severity of adverse effects can be increased when Glatiramer is combined with Leflunomide. |
Atazanavir | Atazanavir The metabolism of Atazanavir can be decreased when combined with Leflunomide. |
Eletriptan | Eletriptan The metabolism of Eletriptan can be decreased when combined with Leflunomide. |
Mefloquine | Mefloquine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Mefloquine is combined with Leflunomide. |
Rosuvastatin | Rosuvastatin The serum concentration of Rosuvastatin can be increased when it is combined with Leflunomide. |
Aprepitant | Aprepitant The metabolism of Leflunomide can be decreased when combined with Aprepitant. |
Interferon Beta-1a Subcutaneous Injection | Interferon Beta-1a Subcutaneous Injection The metabolism of Leflunomide can be decreased when combined with Interferon beta-1a. |
Tegaserod | Tegaserod The metabolism of Leflunomide can be decreased when combined with Tegaserod. |
Frovatriptan | Frovatriptan The serum concentration of Frovatriptan can be decreased when it is combined with Leflunomide. |
Gemifloxacin | Gemifloxacin The metabolism of Leflunomide can be decreased when combined with Gemifloxacin. |
Progesterone | Progesterone Progesterone may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Infliximab Injection | Infliximab Injection The risk or severity of adverse effects can be increased when Infliximab is combined with Leflunomide. |
Oxandrolone | Oxandrolone The metabolism of Leflunomide can be decreased when combined with Oxandrolone. |
Duloxetine | Duloxetine The serum concentration of Duloxetine can be decreased when it is combined with Leflunomide. |
Bosentan | Bosentan The metabolism of Leflunomide can be increased when combined with Bosentan. |
Cinacalcet | Cinacalcet The serum concentration of Cinacalcet can be decreased when it is combined with Leflunomide. |
Natalizumab Injection | Natalizumab Injection The risk or severity of adverse effects can be increased when Leflunomide is combined with Natalizumab. |
Erlotinib | Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Leflunomide. |
Ganciclovir | Ganciclovir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Ganciclovir is combined with Leflunomide. |
Voriconazole | Voriconazole The metabolism of Leflunomide can be decreased when combined with Voriconazole. |
Entecavir | Entecavir The serum concentration of Entecavir can be decreased when it is combined with Leflunomide. |
Peginterferon Alfa-2a Injection | Peginterferon Alfa-2a Injection The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Leflunomide. |
Peginterferon Alfa-2b (PEG-Intron) | Peginterferon Alfa-2b (PEG-Intron) The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Leflunomide. |
Ibandronate | Ibandronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Ibandronate is combined with Leflunomide. |
Ramelteon | Ramelteon The serum concentration of Ramelteon can be decreased when it is combined with Leflunomide. |
Deferasirox | Deferasirox The serum concentration of Leflunomide can be increased when it is combined with Deferasirox. |
Phenylephrine | Phenylephrine The metabolism of Leflunomide can be increased when combined with Phenylephrine. |
Felbamate | Felbamate The metabolism of Leflunomide can be decreased when combined with Felbamate. |
Abatacept Injection | Abatacept Injection The risk or severity of adverse effects can be increased when Abatacept is combined with Leflunomide. |
Rasagiline | Rasagiline The serum concentration of Rasagiline can be decreased when it is combined with Leflunomide. |
Imatinib | Imatinib The risk or severity of adverse effects can be increased when Leflunomide is combined with Imatinib. |
Bevacizumab Injection | Bevacizumab Injection The risk or severity of adverse effects can be increased when Bevacizumab is combined with Leflunomide. |
Gefitinib | Gefitinib Gefitinib may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Bortezomib | Bortezomib The risk or severity of adverse effects can be increased when Leflunomide is combined with Bortezomib. |
Clofarabine Injection | Clofarabine Injection The risk or severity of adverse effects can be increased when Clofarabine is combined with Leflunomide. |
Hepatitis B Vaccine | Hepatitis B Vaccine The therapeutic efficacy of Hepatitis B Vaccine (Recombinant) can be decreased when used in combination with Leflunomide. |
Influenza Vaccine, Inactivated or Recombinant | Influenza Vaccine, Inactivated or Recombinant The therapeutic efficacy of Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Leflunomide. |
Influenza Vaccine, Live Intranasal | Influenza Vaccine, Live Intranasal The risk or severity of infection can be increased when Typhoid Vaccine Live is combined with Leflunomide. |
Live Shingles (Zoster) Vaccine (ZVL) | Live Shingles (Zoster) Vaccine (ZVL) The risk or severity of infection can be increased when Varicella Zoster Vaccine (Live/attenuated) is combined with Leflunomide. |
Insulin Glulisine (rDNA origin) Injection | Insulin Glulisine (rDNA origin) Injection The metabolism of Leflunomide can be increased when combined with Insulin glulisine. |
Oxaliplatin Injection | Oxaliplatin Injection The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Leflunomide. |
Primaquine | Primaquine The serum concentration of Primaquine can be decreased when it is combined with Leflunomide. |
Rituximab Injection | Rituximab Injection The risk or severity of adverse effects can be increased when Rituximab is combined with Leflunomide. |
Pemetrexed Injection | Pemetrexed Injection The risk or severity of adverse effects can be increased when Leflunomide is combined with Pemetrexed. |
Nabilone | Nabilone The metabolism of Leflunomide can be decreased when combined with Nabilone. |
Vorinostat | Vorinostat The risk or severity of adverse effects can be increased when Vorinostat is combined with Leflunomide. |
Sorafenib | Sorafenib The risk or severity of adverse effects can be increased when Leflunomide is combined with Sorafenib. |
Sunitinib | Sunitinib The risk or severity of adverse effects can be increased when Sunitinib is combined with Leflunomide. |
Dronabinol | Dronabinol Dronabinol may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Dasatinib | Dasatinib The risk or severity of adverse effects can be increased when Leflunomide is combined with Dasatinib. |
Mexiletine | Mexiletine The serum concentration of Mexiletine can be decreased when it is combined with Leflunomide. |
Armodafinil | Armodafinil The metabolism of Leflunomide can be decreased when combined with Armodafinil. |
Azacitidine Injection | Azacitidine Injection The risk or severity of adverse effects can be increased when Azacitidine is combined with Leflunomide. |
Ivermectin | Ivermectin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Ivermectin is combined with Leflunomide. |
Temsirolimus | Temsirolimus The risk or severity of adverse effects can be increased when Temsirolimus is combined with Leflunomide. |
Nelarabine Injection | Nelarabine Injection The risk or severity of adverse effects can be increased when Nelarabine is combined with Leflunomide. |
Lenalidomide | Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Leflunomide. |
Nilotinib | Nilotinib The risk or severity of adverse effects can be increased when Nilotinib is combined with Leflunomide. |
Raltegravir | Raltegravir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Leflunomide is combined with Raltegravir. |
Bexarotene | Bexarotene The risk or severity of adverse effects can be increased when Bexarotene is combined with Leflunomide. |
Budesonide | Budesonide The risk or severity of adverse effects can be increased when Budesonide is combined with Leflunomide. |
Chloramphenicol Injection | Chloramphenicol Injection The risk or severity of adverse effects can be increased when Chloramphenicol is combined with Leflunomide. |
Decitabine Injection | Decitabine Injection The risk or severity of adverse effects can be increased when Decitabine is combined with Leflunomide. |
Etravirine | Etravirine The metabolism of Etravirine can be decreased when combined with Leflunomide. |
Arsenic Trioxide Injection | Arsenic Trioxide Injection The risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Leflunomide. |
Mitoxantrone Injection | Mitoxantrone Injection The risk or severity of adverse effects can be increased when Mitoxantrone is combined with Leflunomide. |
Tretinoin | Tretinoin The risk or severity of adverse effects can be increased when Tretinoin is combined with Leflunomide. |
Bendamustine Injection | Bendamustine Injection The risk or severity of adverse effects can be increased when Leflunomide is combined with Bendamustine. |
Flecainide | Flecainide The serum concentration of Leflunomide can be decreased when it is combined with Flecainide. |
Certolizumab Injection | Certolizumab Injection The risk or severity of adverse effects can be increased when Certolizumab pegol is combined with Leflunomide. |
Ixabepilone Injection | Ixabepilone Injection The risk or severity of adverse effects can be increased when Ixabepilone is combined with Leflunomide. |
Irinotecan Injection | Irinotecan Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Leflunomide. |
Daptomycin Injection | Daptomycin Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Leflunomide. |
Estramustine | Estramustine The risk or severity of adverse effects can be increased when Estramustine is combined with Leflunomide. |
Praziquantel | Praziquantel The serum concentration of Praziquantel can be decreased when it is combined with Leflunomide. |
Alemtuzumab Injection (Chronic Lymphocytic Leukemia) | Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Leflunomide. |
Naltrexone Injection | Naltrexone Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Leflunomide. |
Dexrazoxane Injection | Dexrazoxane Injection The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Leflunomide. |
Eltrombopag | Eltrombopag The serum concentration of Eltrombopag can be decreased when it is combined with Leflunomide. |
Ibritumomab Injection | Ibritumomab Injection The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Leflunomide. |
Betaxolol | Betaxolol The serum concentration of Betaxolol can be decreased when it is combined with Leflunomide. |
Prasugrel | Prasugrel The metabolism of Prasugrel can be decreased when combined with Leflunomide. |
Lacosamide | Lacosamide The metabolism of Lacosamide can be decreased when combined with Leflunomide. |
Everolimus | Everolimus The risk or severity of adverse effects can be increased when Everolimus is combined with Leflunomide. |
Pralatrexate Injection | Pralatrexate Injection The risk or severity of adverse effects can be increased when Pralatrexate is combined with Leflunomide. |
Tapentadol | Tapentadol The metabolism of Tapentadol can be decreased when combined with Leflunomide. |
Topotecan | Topotecan The risk or severity of adverse effects can be increased when Topotecan is combined with Leflunomide. |
Golimumab Injection | Golimumab Injection The risk or severity of adverse effects can be increased when Golimumab is combined with Leflunomide. |
Pazopanib | Pazopanib The risk or severity of adverse effects can be increased when Leflunomide is combined with Pazopanib. |
Asenapine | Asenapine The serum concentration of Asenapine can be decreased when it is combined with Leflunomide. |
Pitavastatin | Pitavastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Leflunomide is combined with Pitavastatin. |
Albendazole | Albendazole The serum concentration of Albendazole can be decreased when it is combined with Leflunomide. |
Denosumab Injection | Denosumab Injection The risk or severity of adverse effects can be increased when Denosumab is combined with Leflunomide. |
Tocilizumab Injection | Tocilizumab Injection The risk or severity of adverse effects can be increased when Tocilizumab is combined with Leflunomide. |
Fingolimod | Fingolimod Leflunomide may increase the immunosuppressive activities of Fingolimod. |
Eribulin Injection | Eribulin Injection The risk or severity of adverse effects can be increased when Eribulin is combined with Leflunomide. |
Cabazitaxel Injection | Cabazitaxel Injection The risk or severity of adverse effects can be increased when Cabazitaxel is combined with Leflunomide. |
Acetaminophen Injection | Acetaminophen Injection The serum concentration of Acetaminophen can be decreased when it is combined with Leflunomide. |
Denileukin Diftitox Injection | Denileukin Diftitox Injection The risk or severity of adverse effects can be increased when Aldesleukin is combined with Leflunomide. |
Sipuleucel-T Injection | Sipuleucel-T Injection The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Leflunomide. |
Belimumab Injection | Belimumab Injection The risk or severity of adverse effects can be increased when Belimumab is combined with Leflunomide. |
Busulfan Injection | Busulfan Injection The risk or severity of adverse effects can be increased when Busulfan is combined with Leflunomide. |
Roflumilast | Roflumilast Roflumilast may increase the immunosuppressive activities of Leflunomide. |
Rilpivirine | Rilpivirine Rilpivirine may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Telaprevir | Telaprevir Glecaprevir may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Cyclophosphamide Injection | Cyclophosphamide Injection The risk or severity of adverse effects can be increased when Cyclophosphamide is combined with Leflunomide. |
Abiraterone | Abiraterone The serum concentration of Leflunomide can be increased when it is combined with Abiraterone. |
Ticagrelor | Ticagrelor The metabolism of Leflunomide can be decreased when combined with Ticagrelor. |
Brentuximab Vedotin Injection | Brentuximab Vedotin Injection The risk or severity of adverse effects can be increased when Brentuximab vedotin is combined with Leflunomide. |
Ruxolitinib | Ruxolitinib The risk or severity of adverse effects can be increased when Ruxolitinib is combined with Leflunomide. |
Vandetanib | Vandetanib Vandetanib may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Vemurafenib | Vemurafenib The serum concentration of Leflunomide can be increased when it is combined with Vemurafenib. |
Vismodegib | Vismodegib Vismodegib may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Belatacept Injection | Belatacept Injection The risk or severity of adverse effects can be increased when Belatacept is combined with Leflunomide. |
Basiliximab Injection | Basiliximab Injection The risk or severity of adverse effects can be increased when Basiliximab is combined with Leflunomide. |
Axitinib | Axitinib The serum concentration of Axitinib can be decreased when it is combined with Leflunomide. |
Melphalan Injection | Melphalan Injection The risk or severity of adverse effects can be increased when Melphalan is combined with Leflunomide. |
Eculizumab Injection | Eculizumab Injection The risk or severity of adverse effects can be increased when Eculizumab is combined with Leflunomide. |
Carfilzomib Injection | Carfilzomib Injection The risk or severity of adverse effects can be increased when Carfilzomib is combined with Leflunomide. |
Iloprost | Iloprost The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Iloprost is combined with Leflunomide. |
Enzalutamide | Enzalutamide The metabolism of Leflunomide can be increased when combined with Enzalutamide. |
Regorafenib | Regorafenib Regorafenib may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Bosutinib | Bosutinib The risk or severity of adverse effects can be increased when Bosutinib is combined with Leflunomide. |
Corticotropin, Repository Injection | Corticotropin, Repository Injection The risk or severity of adverse effects can be increased when Corticotropin is combined with Leflunomide. |
Teriflunomide | Teriflunomide The risk or severity of adverse effects can be increased when Leflunomide is combined with Teriflunomide. |
Cabozantinib (thyroid cancer) | Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Leflunomide. |
Tofacitinib | Tofacitinib The risk or severity of adverse effects can be increased when Tofacitinib is combined with Leflunomide. |
Dimethyl Fumarate | Dimethyl Fumarate The risk or severity of adverse effects can be increased when Dimethyl fumarate is combined with Leflunomide. |
Ponatinib | Ponatinib The risk or severity of adverse effects can be increased when Ponatinib is combined with Leflunomide. |
Pomalidomide | Pomalidomide The risk or severity of adverse effects can be increased when Leflunomide is combined with Pomalidomide. |
Ado-trastuzumab Emtansine Injection | Ado-trastuzumab Emtansine Injection The risk or severity of adverse effects can be increased when Trastuzumab emtansine is combined with Leflunomide. |
Apixaban | Apixaban The metabolism of Apixaban can be decreased when combined with Leflunomide. |
Dabrafenib | Dabrafenib The metabolism of Leflunomide can be increased when combined with Dabrafenib. |
Ospemifene | Ospemifene The metabolism of Ospemifene can be decreased when combined with Leflunomide. |
Afatinib | Afatinib Afatinib may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Vortioxetine | Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Leflunomide. |
Perampanel | Perampanel The serum concentration of Perampanel can be decreased when it is combined with Leflunomide. |
Ibrutinib | Ibrutinib The risk or severity of adverse effects can be increased when Ibrutinib is combined with Leflunomide. |
Ketorolac Injection | Ketorolac Injection The metabolism of Ketorolac can be decreased when combined with Leflunomide. |
Obinutuzumab Injection | Obinutuzumab Injection The risk or severity of adverse effects can be increased when Obinutuzumab is combined with Leflunomide. |
Simeprevir | Simeprevir Simeprevir may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Dapagliflozin | Dapagliflozin The serum concentration of Dapagliflozin can be decreased when it is combined with Leflunomide. |
Apremilast | Apremilast The risk or severity of adverse effects can be increased when Leflunomide is combined with Apremilast. |
Ceritinib | Ceritinib The metabolism of Leflunomide can be decreased when combined with Ceritinib. |
Siltuximab Injection | Siltuximab Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Leflunomide. |
Vedolizumab Injection | Vedolizumab Injection The risk or severity of adverse effects can be increased when Vedolizumab is combined with Leflunomide. |
Belinostat Injection | Belinostat Injection The risk or severity of adverse effects can be increased when Belinostat is combined with Leflunomide. |
Idelalisib | Idelalisib The risk or severity of adverse effects can be increased when Idelalisib is combined with Leflunomide. |
Testosterone Injection | Testosterone Injection The metabolism of Testosterone can be decreased when combined with Leflunomide. |
Oritavancin Injection | Oritavancin Injection The metabolism of Leflunomide can be decreased when combined with Oritavancin. |
Peginterferon Beta-1a Injection | Peginterferon Beta-1a Injection The risk or severity of adverse effects can be increased when Peginterferon beta-1a is combined with Leflunomide. |
Olaparib | Olaparib The risk or severity of adverse effects can be increased when Olaparib is combined with Leflunomide. |
Blinatumomab Injection | Blinatumomab Injection The risk or severity of adverse effects can be increased when Blinatumomab is combined with Leflunomide. |
Tasimelteon | Tasimelteon The serum concentration of Tasimelteon can be decreased when it is combined with Leflunomide. |
Pirfenidone | Pirfenidone The risk or severity of adverse effects can be increased when Leflunomide is combined with Pirfenidone. |
Secukinumab Injection | Secukinumab Injection The risk or severity of adverse effects can be increased when Secukinumab is combined with Leflunomide. |
Palbociclib | Palbociclib The risk or severity of adverse effects can be increased when Palbociclib is combined with Leflunomide. |
Insulin Human Inhalation | Insulin Human Inhalation The metabolism of Leflunomide can be increased when combined with Insulin human. |
Lenvatinib | Lenvatinib The metabolism of Leflunomide can be decreased when combined with Lenvatinib. |
Panobinostat | Panobinostat The risk or severity of adverse effects can be increased when Panobinostat is combined with Leflunomide. |
Dinutuximab Injection | Dinutuximab Injection The risk or severity of adverse effects can be increased when Dinutuximab is combined with Leflunomide. |
Haloperidol Injection | Haloperidol Injection The serum concentration of Haloperidol can be decreased when it is combined with Leflunomide. |
Rolapitant | Rolapitant Rolapitant may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Prednisolone | Prednisolone The risk or severity of adverse effects can be increased when Prednisolone is combined with Leflunomide. |
Daclatasvir | Daclatasvir Daclatasvir may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Insulin Degludec (rDNA Origin) Injection | Insulin Degludec (rDNA Origin) Injection The metabolism of Leflunomide can be increased when combined with Insulin degludec. |
Mepolizumab Injection | Mepolizumab Injection The risk or severity of adverse effects can be increased when Mepolizumab is combined with Leflunomide. |
Trabectedin Injection | Trabectedin Injection The risk or severity of adverse effects can be increased when Trabectedin is combined with Leflunomide. |
Osimertinib | Osimertinib The serum concentration of Leflunomide can be decreased when it is combined with Osimertinib. |
Alectinib | Alectinib Alectinib may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Lesinurad | Lesinurad The metabolism of Lesinurad can be decreased when combined with Leflunomide. |
Amphotericin B Liposomal Injection | Amphotericin B Liposomal Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Amphotericin B is combined with Leflunomide. |
Dexamethasone Injection | Dexamethasone Injection The risk or severity of adverse effects can be increased when Dexamethasone is combined with Leflunomide. |
Ixekizumab Injection | Ixekizumab Injection The risk or severity of adverse effects can be increased when Ixekizumab is combined with Leflunomide. |
Brivaracetam Injection | Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Leflunomide. |
Venetoclax | Venetoclax Venetoclax may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Cobicistat | Cobicistat Cobicistat may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Obeticholic Acid | Obeticholic Acid The metabolism of Leflunomide can be decreased when combined with Obeticholic acid. |
Diphenhydramine Injection | Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Leflunomide. |
Rucaparib | Rucaparib The serum concentration of Rucaparib can be decreased when it is combined with Leflunomide. |
Brodalumab Injection | Brodalumab Injection The risk or severity of adverse effects can be increased when Brodalumab is combined with Leflunomide. |
Brigatinib | Brigatinib Brigatinib may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Doxepin (Insomnia) | Doxepin (Insomnia) The serum concentration of Doxepin can be decreased when it is combined with Leflunomide. |
Deflazacort | Deflazacort The risk or severity of adverse effects can be increased when Deflazacort is combined with Leflunomide. |
Safinamide | Safinamide Safinamide may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Ocrelizumab Injection | Ocrelizumab Injection The risk or severity of adverse effects can be increased when Ocrelizumab is combined with Leflunomide. |
Sarilumab Injection | Sarilumab Injection The risk or severity of adverse effects can be increased when Sarilumab is combined with Leflunomide. |
Midostaurin | Midostaurin The metabolism of Leflunomide can be decreased when combined with Midostaurin. |
Guselkumab Injection | Guselkumab Injection The risk or severity of adverse effects can be increased when Guselkumab is combined with Leflunomide. |
Enasidenib | Enasidenib The serum concentration of Enasidenib can be decreased when it is combined with Leflunomide. |
Delafloxacin | Delafloxacin The metabolism of Leflunomide can be increased when combined with Delafloxacin. |
Abemaciclib | Abemaciclib Abemaciclib may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Gemtuzumab Ozogamicin Injection | Gemtuzumab Ozogamicin Injection The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Leflunomide. |
Letermovir | Letermovir Letermovir may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Buprenorphine Injection | Buprenorphine Injection Buprenorphine may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Apalutamide | Apalutamide Apalutamide may increase the excretion rate of Leflunomide which could result in a lower serum level and potentially a reduction in efficacy. |
Penicillamine | Penicillamine The risk or severity of adverse effects can be increased when Penicillamine is combined with Leflunomide. |
Fostamatinib | Fostamatinib Fostamatinib may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Avatrombopag | Avatrombopag Avatrombopag may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Baricitinib | Baricitinib The risk or severity of adverse effects can be increased when Baricitinib is combined with Leflunomide. |
Lofexidine | Lofexidine The serum concentration of Lofexidine can be decreased when it is combined with Leflunomide. |
Binimetinib | Binimetinib The serum concentration of Binimetinib can be decreased when it is combined with Leflunomide. |
Cannabidiol | Cannabidiol Cannabidiol may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Dacomitinib | Dacomitinib The metabolism of Leflunomide can be decreased when combined with Dacomitinib. |
Stiripentol | Stiripentol The serum concentration of Stiripentol can be decreased when it is combined with Leflunomide. |
Gilteritinib | Gilteritinib Gilteritinib may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Glasdegib | Glasdegib Glasdegib may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Paclitaxel (with albumin) Injection | Paclitaxel (with albumin) Injection The risk or severity of adverse effects can be increased when Paclitaxel is combined with Leflunomide. |
Rifamycin | Rifamycin The metabolism of Leflunomide can be decreased when combined with Rifamycin. |
Ravulizumab-cwvz Injection | Ravulizumab-cwvz Injection The risk or severity of adverse effects can be increased when Ravulizumab is combined with Leflunomide. |
Emapalumab-lzsg Injection | Emapalumab-lzsg Injection The risk or severity of adverse effects can be increased when Emapalumab is combined with Leflunomide. |
Siponimod | Siponimod The risk or severity of adverse effects can be increased when Siponimod is combined with Leflunomide. |
Acyclovir Ophthalmic | Acyclovir Ophthalmic The serum concentration of Acyclovir can be decreased when it is combined with Leflunomide. |
Erdafitinib | Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Leflunomide. |
Risankizumab-rzaa Injection | Risankizumab-rzaa Injection The risk or severity of adverse effects can be increased when Risankizumab is combined with Leflunomide. |
Alpelisib | Alpelisib The serum concentration of Leflunomide can be decreased when it is combined with Alpelisib. |
Cladribine | Cladribine The risk or severity of adverse effects can be increased when Cladribine is combined with Leflunomide. |
Darolutamide | Darolutamide The serum concentration of Leflunomide can be increased when it is combined with Darolutamide. |
Triclabendazole | Triclabendazole The serum concentration of Triclabendazole can be decreased when it is combined with Leflunomide. |
Istradefylline | Istradefylline The serum concentration of Istradefylline can be decreased when it is combined with Leflunomide. |
Pitolisant | Pitolisant The metabolism of Leflunomide can be increased when combined with Pitolisant. |
Fedratinib | Fedratinib Fedratinib may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Phenytoin Injection | Phenytoin Injection The metabolism of Phenytoin can be decreased when combined with Leflunomide. |
Fosphenytoin Injection | Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Leflunomide. |
Voxelotor | Voxelotor The metabolism of Voxelotor can be decreased when combined with Leflunomide. |
Avapritinib | Avapritinib The metabolism of Avapritinib can be decreased when combined with Leflunomide. |
Lasmiditan | Lasmiditan The serum concentration of Leflunomide can be increased when it is combined with Lasmiditan. |
Ozanimod | Ozanimod The risk or severity of adverse effects can be increased when Ozanimod is combined with Leflunomide. |
Selumetinib | Selumetinib The serum concentration of Selumetinib can be decreased when it is combined with Leflunomide. |
Ripretinib | Ripretinib Ripretinib may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Capmatinib | Capmatinib The serum concentration of Leflunomide can be increased when it is combined with Capmatinib. |
Fostemsavir | Fostemsavir Fostemsavir may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Pralsetinib | Pralsetinib Pralsetinib may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Satralizumab-mwge Injection | Satralizumab-mwge Injection The serum concentration of Leflunomide can be decreased when it is combined with Satralizumab. |
Viloxazine | Viloxazine The metabolism of Leflunomide can be decreased when combined with Viloxazine. |
Theophylline | Theophylline The serum concentration of Theophylline can be decreased when it is combined with Leflunomide. |
Indomethacin | Indomethacin The risk or severity of adverse effects can be increased when Indomethacin is combined with Leflunomide. |
Mefenamic Acid | Mefenamic Acid The metabolism of Mefenamic acid can be decreased when combined with Leflunomide. |
Naproxen | Naproxen The serum concentration of Naproxen can be decreased when it is combined with Leflunomide. |
Isotretinoin | Isotretinoin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Isotretinoin is combined with Leflunomide. |
Hydroxyurea | Hydroxyurea The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Leflunomide. |
Floxuridine | Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Leflunomide. |
Phenobarbital | Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Leflunomide. |
Methotrexate Injection | Methotrexate Injection The risk or severity of adverse effects can be increased when Methotrexate is combined with Leflunomide. |
Primidone | Primidone The metabolism of Leflunomide can be increased when combined with Primidone. |
Chlorpromazine | Chlorpromazine The serum concentration of Chlorpromazine can be decreased when it is combined with Leflunomide. |
Diazepam | Diazepam The metabolism of Diazepam can be decreased when combined with Leflunomide. |
Carmustine | Carmustine The risk or severity of adverse effects can be increased when Leflunomide is combined with Carmustine. |
Tranylcypromine | Tranylcypromine The metabolism of Leflunomide can be decreased when combined with Tranylcypromine. |
Procarbazine | Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Leflunomide. |
Thioguanine | Thioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Leflunomide. |
Minocycline | Minocycline The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Minocycline is combined with Leflunomide. |
Trifluoperazine | Trifluoperazine The serum concentration of Trifluoperazine can be decreased when it is combined with Leflunomide. |
Bleomycin | Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Leflunomide. |
Dapsone | Dapsone The metabolism of Dapsone can be decreased when combined with Leflunomide. |
Sulfadiazine | Sulfadiazine The metabolism of Leflunomide can be decreased when combined with Sulfadiazine. |
Methadone | Methadone The metabolism of Methadone can be decreased when combined with Leflunomide. |
Colestipol | Colestipol Colestipol may increase the excretion rate of Leflunomide which could result in a lower serum level and potentially a reduction in efficacy. |
Maprotiline | Maprotiline The serum concentration of Maprotiline can be decreased when it is combined with Leflunomide. |
Ibuprofen | Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Leflunomide. |
Orphenadrine | Orphenadrine The metabolism of Leflunomide can be decreased when combined with Orphenadrine. |
Perphenazine | Perphenazine The serum concentration of Perphenazine can be decreased when it is combined with Leflunomide. |
Azathioprine | Azathioprine The risk or severity of adverse effects can be increased when Leflunomide is combined with Azathioprine. |
Sulfasalazine | Sulfasalazine The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Leflunomide. |
Hydrocortisone | Hydrocortisone The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Leflunomide. |
Lomustine | Lomustine The risk or severity of adverse effects can be increased when Lomustine is combined with Leflunomide. |
Doxorubicin | Doxorubicin The risk or severity of adverse effects can be increased when Doxorubicin is combined with Leflunomide. |
Cytarabine | Cytarabine The risk or severity of adverse effects can be increased when Cytarabine is combined with Leflunomide. |
Mechlorethamine | Mechlorethamine The risk or severity of adverse effects can be increased when Mechlorethamine is combined with Leflunomide. |
Dactinomycin | Dactinomycin The risk or severity of adverse effects can be increased when Dactinomycin is combined with Leflunomide. |
Carbamazepine | Carbamazepine The risk or severity of adverse effects can be increased when Leflunomide is combined with Carbamazepine. |
Methyldopa | Methyldopa The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Methyldopa is combined with Leflunomide. |
Clonidine | Clonidine The serum concentration of Clonidine can be decreased when it is combined with Leflunomide. |
Cimetidine | Cimetidine The metabolism of Leflunomide can be decreased when combined with Cimetidine. |
Warfarin | Warfarin The serum concentration of Warfarin can be decreased when it is combined with Leflunomide. |
Promethazine | Promethazine The metabolism of Leflunomide can be decreased when combined with Promethazine. |
Daunorubicin | Daunorubicin The risk or severity of adverse effects can be increased when Daunorubicin is combined with Leflunomide. |
Griseofulvin | Griseofulvin The metabolism of Leflunomide can be increased when combined with Griseofulvin. |
Chloroquine | Chloroquine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Chloroquine is combined with Leflunomide. |
Quinine | Quinine The serum concentration of Quinine can be decreased when it is combined with Leflunomide. |
Triamterene | Triamterene The serum concentration of Triamterene can be decreased when it is combined with Leflunomide. |
Sulfinpyrazone | Sulfinpyrazone The metabolism of Leflunomide can be decreased when combined with Sulfinpyrazone. |
Secobarbital | Secobarbital The metabolism of Leflunomide can be increased when combined with Secobarbital. |
Amitriptyline | Amitriptyline The serum concentration of Amitriptyline can be decreased when it is combined with Leflunomide. |
Imipramine | Imipramine The serum concentration of Imipramine can be decreased when it is combined with Leflunomide. |
Probenecid | Probenecid The metabolism of Leflunomide can be decreased when combined with Probenecid. |
Quinidine | Quinidine The metabolism of Leflunomide can be decreased when combined with Quinidine. |
Procainamide | Procainamide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Procainamide is combined with Leflunomide. |
Isoniazid | Isoniazid The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Isoniazid is combined with Leflunomide. |
Rifampin | Rifampin The serum concentration of teriflunomide (A77 1726), an active metabolite of Leflunomide, can be increased when used in combination with Rifampicin. |
Disopyramide | Disopyramide The serum concentration of Disopyramide can be decreased when it is combined with Leflunomide. |
Valproic Acid | Valproic Acid The metabolism of Leflunomide can be decreased when combined with Valproic acid. |
Tamoxifen | Tamoxifen The serum concentration of Leflunomide can be decreased when it is combined with Tamoxifen. |
Mitomycin | Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Leflunomide. |
Methimazole | Methimazole The risk or severity of adverse effects can be increased when Methimazole is combined with Leflunomide. |
Propylthiouracil | Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Leflunomide. |
Chlorpropamide | Chlorpropamide The metabolism of Chlorpropamide can be decreased when combined with Leflunomide. |
Tolbutamide | Tolbutamide The serum concentration of Tolbutamide can be increased when it is combined with Leflunomide. |
Tolazamide | Tolazamide The metabolism of Tolazamide can be decreased when combined with Leflunomide. |
Dextromethorphan | Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Leflunomide. |
Cyclobenzaprine | Cyclobenzaprine The serum concentration of Cyclobenzaprine can be decreased when it is combined with Leflunomide. |
Niacin | Niacin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Niacin is combined with Leflunomide. |
Baclofen | Baclofen The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Baclofen is combined with Leflunomide. |
Chlorzoxazone | Chlorzoxazone The serum concentration of Chlorzoxazone can be decreased when it is combined with Leflunomide. |
Propranolol (Cardiovascular) | Propranolol (Cardiovascular) The serum concentration of Propranolol can be decreased when it is combined with Leflunomide. |
Amphotericin B Injection | Amphotericin B Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Amphotericin B is combined with Leflunomide. |
Mercaptopurine | Mercaptopurine The risk or severity of adverse effects can be increased when Mercaptopurine is combined with Leflunomide. |
Cholestyramine Resin | Cholestyramine Resin Cholestyramine may increase the excretion rate of Leflunomide which could result in a lower serum level and potentially a reduction in efficacy. |
Fluorouracil Injection | Fluorouracil Injection The risk or severity of adverse effects can be increased when Leflunomide is combined with Fluorouracil. |
Colchicine | Colchicine The risk or severity of adverse effects can be increased when Colchicine is combined with Leflunomide. |
Dacarbazine | Dacarbazine The risk or severity of adverse effects can be increased when Leflunomide is combined with Dacarbazine. |
Bacillus Calmette-Guerin (BCG) Vaccine | Bacillus Calmette-Guerin (BCG) Vaccine The risk or severity of infection can be increased when Bacillus calmette-guerin substrain tice live antigen is combined with Leflunomide. |
Ketoconazole | Ketoconazole The metabolism of Leflunomide can be decreased when combined with Ketoconazole. |
Thiotepa Injection | Thiotepa Injection The risk or severity of adverse effects can be increased when Thiotepa is combined with Leflunomide. |
Vincristine Injection | Vincristine Injection The risk or severity of adverse effects can be increased when Vincristine is combined with Leflunomide. |
Captopril | Captopril The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Leflunomide is combined with Captopril. |
Vinblastine | Vinblastine The risk or severity of adverse effects can be increased when Vinblastine is combined with Leflunomide. |
Thiothixene | Thiothixene The serum concentration of Thiothixene can be decreased when it is combined with Leflunomide. |
Aspirin | Aspirin The metabolism of Acetylsalicylic acid can be decreased when combined with Leflunomide. |
Chlorambucil | Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Leflunomide. |
Triazolam | Triazolam The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Triazolam is combined with Leflunomide. |
Trimethoprim | Trimethoprim The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Leflunomide. |
Diltiazem | Diltiazem The metabolism of Diltiazem can be decreased when combined with Leflunomide. |
Nifedipine | Nifedipine The serum concentration of Nifedipine can be decreased when it is combined with Leflunomide. |
Verapamil | Verapamil The serum concentration of Verapamil can be decreased when it is combined with Leflunomide. |
Cisplatin Injection | Cisplatin Injection The risk or severity of adverse effects can be increased when Cisplatin is combined with Leflunomide. |
Piroxicam | Piroxicam The metabolism of Piroxicam can be decreased when combined with Leflunomide. |
Bumetanide | Bumetanide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Bumetanide is combined with Leflunomide. |
Streptozocin | Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Leflunomide. |
Etoposide | Etoposide The risk or severity of adverse effects can be increased when Leflunomide is combined with Etoposide. |
Glyburide | Glyburide The metabolism of Leflunomide can be decreased when combined with Glyburide. |
Glipizide | Glipizide The metabolism of Glipizide can be decreased when combined with Leflunomide. |
Nafcillin Injection | Nafcillin Injection The metabolism of Leflunomide can be increased when combined with Nafcillin. |
Pentoxifylline | Pentoxifylline The serum concentration of Pentoxifylline can be decreased when it is combined with Leflunomide. |
Leuprolide Injection | Leuprolide Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Leuprolide is combined with Leflunomide. |
Gemfibrozil | Gemfibrozil The metabolism of Leflunomide can be decreased when combined with Gemfibrozil. |
Guanabenz | Guanabenz The serum concentration of Guanabenz can be decreased when it is combined with Leflunomide. |
Pimozide | Pimozide The serum concentration of Pimozide can be decreased when it is combined with Leflunomide. |
Enalapril | Enalapril The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Enalapril is combined with Leflunomide. |
Flurbiprofen | Flurbiprofen The metabolism of Flurbiprofen can be decreased when combined with Leflunomide. |
Amiodarone | Amiodarone The metabolism of Leflunomide can be decreased when combined with Amiodarone. |
Lovastatin | Lovastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Leflunomide. |
Ciprofloxacin | Ciprofloxacin The metabolism of Leflunomide can be decreased when combined with Ciprofloxacin. |
Diclofenac | Diclofenac The serum concentration of Diclofenac can be decreased when it is combined with Leflunomide. |
Fluoxetine | Fluoxetine The serum concentration of Fluoxetine can be decreased when it is combined with Leflunomide. |
Interferon Alfa-2b Injection | Interferon Alfa-2b Injection The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Leflunomide. |
Clozapine | Clozapine The serum concentration of Clozapine can be decreased when it is combined with Leflunomide. |
Idarubicin | Idarubicin The risk or severity of adverse effects can be increased when Idarubicin is combined with Leflunomide. |
Ofloxacin | Ofloxacin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Leflunomide is combined with Ofloxacin. |
Fludarabine Injection | Fludarabine Injection The risk or severity of adverse effects can be increased when Fludarabine is combined with Leflunomide. |
Pentostatin Injection | Pentostatin Injection The risk or severity of adverse effects can be increased when Pentostatin is combined with Leflunomide. |
Etodolac | Etodolac The metabolism of Etodolac can be decreased when combined with Leflunomide. |
Felodipine | Felodipine The metabolism of Leflunomide can be decreased when combined with Felodipine. |
Nabumetone | Nabumetone The serum concentration of Nabumetone can be decreased when it is combined with Leflunomide. |
Pravastatin | Pravastatin Pravastatin may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Simvastatin | Simvastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Leflunomide. |
Teniposide Injection | Teniposide Injection The risk or severity of adverse effects can be increased when Teniposide is combined with Leflunomide. |
Atovaquone | Atovaquone The metabolism of Leflunomide can be decreased when combined with Atovaquone. |
Zolpidem | Zolpidem The serum concentration of Zolpidem can be decreased when it is combined with Leflunomide. |
Doxazosin | Doxazosin The metabolism of Doxazosin can be decreased when combined with Leflunomide. |
Omeprazole | Omeprazole Omeprazole may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Cisapride | Cisapride The metabolism of Leflunomide can be decreased when combined with Cisapride. |
Fluvastatin | Fluvastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Fluvastatin is combined with Leflunomide. |
Venlafaxine | Venlafaxine The metabolism of Venlafaxine can be decreased when combined with Leflunomide. |
Nizatidine | Nizatidine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Nizatidine is combined with Leflunomide. |
Stavudine | Stavudine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Stavudine is combined with Leflunomide. |
Fluvoxamine | Fluvoxamine The serum concentration of Fluvoxamine can be decreased when it is combined with Leflunomide. |
Losartan | Losartan The metabolism of Losartan can be decreased when combined with Leflunomide. |
Vinorelbine Injection | Vinorelbine Injection The risk or severity of adverse effects can be increased when Vinorelbine is combined with Leflunomide. |
Carboplatin Injection | Carboplatin Injection The risk or severity of adverse effects can be increased when Carboplatin is combined with Leflunomide. |
Lansoprazole | Lansoprazole Lansoprazole may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Ifosfamide Injection | Ifosfamide Injection The risk or severity of adverse effects can be increased when Ifosfamide is combined with Leflunomide. |
Pegaspargase Injection | Pegaspargase Injection The risk or severity of adverse effects can be increased when Pegaspargase is combined with Leflunomide. |
Nicardipine | Nicardipine The metabolism of Leflunomide can be decreased when combined with Nicardipine. |
Bupropion | Bupropion The metabolism of Bupropion can be decreased when combined with Leflunomide. |
Ticlopidine | Ticlopidine The metabolism of Leflunomide can be decreased when combined with Ticlopidine. |
Saquinavir | Saquinavir Saquinavir may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Lamivudine | Lamivudine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lamivudine is combined with Leflunomide. |
Riluzole | Riluzole The serum concentration of Riluzole can be decreased when it is combined with Leflunomide. |
Glimepiride | Glimepiride The metabolism of Glimepiride can be decreased when combined with Leflunomide. |
Gemcitabine Injection | Gemcitabine Injection The risk or severity of adverse effects can be increased when Gemcitabine is combined with Leflunomide. |
Indinavir | Indinavir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Indinavir is combined with Leflunomide. |
Ritonavir | Ritonavir Ritonavir may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Docetaxel Injection | Docetaxel Injection The risk or severity of adverse effects can be increased when Docetaxel is combined with Leflunomide. |
Clomipramine | Clomipramine The serum concentration of Clomipramine can be decreased when it is combined with Leflunomide. |
Zafirlukast | Zafirlukast The metabolism of Leflunomide can be decreased when combined with Zafirlukast. |
Mirtazapine | Mirtazapine The serum concentration of Mirtazapine can be decreased when it is combined with Leflunomide. |
Zileuton | Zileuton The serum concentration of Zileuton can be decreased when it is combined with Leflunomide. |
Valsartan | Valsartan The metabolism of Leflunomide can be decreased when combined with Valsartan. |
Insulin Lispro Injection | Insulin Lispro Injection The metabolism of Leflunomide can be increased when combined with Insulin lispro. |
Donepezil | Donepezil The metabolism of Donepezil can be decreased when combined with Leflunomide. |
Nelfinavir | Nelfinavir Nelfinavir may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Carvedilol | Carvedilol The serum concentration of Carvedilol can be decreased when it is combined with Leflunomide. |
Nilutamide | Nilutamide The metabolism of Leflunomide can be decreased when combined with Nilutamide. |
Flutamide | Flutamide The serum concentration of Flutamide can be decreased when it is combined with Leflunomide. |
Selegiline | Selegiline The serum concentration of Selegiline can be decreased when it is combined with Leflunomide. |
Bicalutamide | Bicalutamide The metabolism of Leflunomide can be decreased when combined with Bicalutamide. |
Sertraline | Sertraline The metabolism of Sertraline can be decreased when combined with Leflunomide. |
Propafenone | Propafenone The serum concentration of Propafenone can be decreased when it is combined with Leflunomide. |
Letrozole | Letrozole The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Letrozole is combined with Leflunomide. |
Irbesartan | Irbesartan The metabolism of Irbesartan can be decreased when combined with Leflunomide. |
Ropinirole | Ropinirole The serum concentration of Ropinirole can be decreased when it is combined with Leflunomide. |
Tolcapone | Tolcapone The metabolism of Leflunomide can be decreased when combined with Tolcapone. |
Citalopram | Citalopram The metabolism of Leflunomide can be decreased when combined with Citalopram. |
Capecitabine | Capecitabine The risk or severity of adverse effects can be increased when Capecitabine is combined with Leflunomide. |
Efavirenz | Efavirenz The serum concentration of Leflunomide can be decreased when it is combined with Efavirenz. |
Sildenafil | Sildenafil The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Leflunomide. |
Trastuzumab Injection | Trastuzumab Injection The risk or severity of adverse effects can be increased when Trastuzumab is combined with Leflunomide. |
Celecoxib | Celecoxib The metabolism of Celecoxib can be decreased when combined with Leflunomide. |
Rosiglitazone | Rosiglitazone The metabolism of Leflunomide can be decreased when combined with Rosiglitazone. |
Tolterodine | Tolterodine The metabolism of Tolterodine can be decreased when combined with Leflunomide. |
Thalidomide | Thalidomide The risk or severity of adverse effects can be increased when Thalidomide is combined with Leflunomide. |
Colesevelam | Colesevelam Colesevelam may increase the excretion rate of Leflunomide which could result in a lower serum level and potentially a reduction in efficacy. |
Nateglinide | Nateglinide The metabolism of Nateglinide can be decreased when combined with Leflunomide. |
Rabeprazole | Rabeprazole Rabeprazole may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
Terbinafine | Terbinafine The serum concentration of Terbinafine can be decreased when it is combined with Leflunomide. |
Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists