Leflunomide

Leflunomide is used alone or in combination with other medications to treat rheumatoid arthritis (a condition in which the body attacks its own joints, causing pain, swelling, and loss of function). Leflunomide is in a class of medications called disease-modifying antirheumatic drugs (DMARDs). It works by decreasing inflammation and slowing the progress of the condition, which can help improve the physical activity of people with rheumatoid arthritis.

Leflunomide comes as a tablet to take by mouth. It is usually taken once a day. Your doctor may tell you to take a larger dose of leflunomide for the first 3 days of treatment. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take leflunomide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor may need to decrease your dose or stop treatment if you experience certain severe side effects. Be sure to tell your doctor how you are feeling during your treatment.

Leflunomide may help control the symptoms of your rheumatoid arthritis but does not cure it. Continue to take leflunomide even if you feel well. Do not stop taking leflunomide without talking to your doctor.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking leflunomide,

• tell your doctor and pharmacist if you are allergic to leflunomide, teriflunomide (Aubagio), any other medications, or any of the ingredients in leflunomide tablets. Ask your pharmacist for a list of the ingredients.

• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin Jantoven); cholestyramine (Prevalite); gold compounds such as auranofin (Ridaura); medications to treat cancer; other medications that suppress the immune system such as azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), and tacrolimus (Astagraf, Prograf); penicillamine (Cuprimine, Depen), and tolbutamide. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

• tell your doctor if you have or have ever had serious infections or if you frequently get infections, cancer or other conditions affecting the bone marrow or the immune system (including human immunodeficiency virus [HIV] and acquired immunodeficiency syndrome [AIDS]), diabetes, or kidney disease.

• tell your doctor if you are breastfeeding. Do not breastfeed while you are taking leflunomide.

• if you are planning to father a child, you should talk to your doctor about stopping leflunomide and receiving a treatment to help to remove this medication from your body more quickly.

• ask your doctor about the safe use of alcoholic beverages while you are taking leflunomide.

• Taking leflunomide may decrease your ability to fight infection. Tell your doctor if you have an infection now or if you have any signs of infection such as fever, cough, or flu-like symptoms. If you experience any of the following symptoms during your treatment with leflunomide, call your doctor: fever; sore throat; cough; flu-like symptoms; area of warm, red, swollen, or painful skin; painful, difficult, or frequent urination; or other signs of infection. Your treatment with leflunomide may need to be interrupted if you have an infection.

• You may already be infected with tuberculosis (TB; a serious lung infection) but not have any symptoms of the disease. In this case, leflunomide may make your infection more serious and cause you to develop symptoms. Tell your doctor if you have or have ever had TB, if you have lived in or visited a country where TB is common, or if you have been around someone who has or has ever had TB. Before you begin your treatment with leflunomide, your doctor will perform a skin test to see if you have TB. If you do have TB, your doctor will treat this infection with antibiotics before you begin taking leflunomide.

• do not have any vaccinations without talking to your doctor.

• you should know that leflunomide may cause high blood pressure. You should have your blood pressure checked before starting treatment and regularly while you are taking this medication.

Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

• Leflunomide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • diarrhea

  • vomiting

  • heartburn

  • headache

  • dizziness

  • weight loss

  • back pain

  • muscle pain or weakness

  • pain, burning, numbness, or tingling in the hands or feet

  • hair loss

  • leg cramps

  • dry skin

• Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS section, call your doctor immediately or get emergency medical treatment:

  • rash with or without a fever

  • hives

  • blisters or peeling of skin

  • mouth sores

  • itching

  • difficulty breathing

  • new or worsening cough

  • chest pain

  • pale skin

• Receiving medications which suppress the immune system may increase the risk of developing certain types of cancer. An increase in cancers was not reported in clinical studies with leflunomide to date. Talk to your doctor about the risks of receiving leflunomide.

• Leflunomide may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom) and light.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

• diarrhea

• stomach pain

• extreme tiredness

• weakness

• pale skin

• fast heartbeat

• shortness of breath

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug	Interaction
Moxifloxacin	Moxifloxacin The metabolism of Leflunomide can be decreased when combined with Moxifloxacin.
Repaglinide	Repaglinide The serum concentration of Repaglinide can be increased when it is combined with Leflunomide.
Montelukast	Montelukast The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Leflunomide.
Insulin Glargine (rDNA origin) Injection	Insulin Glargine (rDNA origin) Injection The metabolism of Leflunomide can be increased when combined with Insulin glargine.
Delavirdine	Delavirdine The metabolism of Leflunomide can be decreased when combined with Delavirdine.
Nevirapine	Nevirapine The metabolism of Leflunomide can be decreased when combined with Nevirapine.
Atorvastatin	Atorvastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Atorvastatin is combined with Leflunomide.
Alendronate	Alendronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Alendronic acid is combined with Leflunomide.
Aminophylline	Aminophylline The serum concentration of Aminophylline can be decreased when it is combined with Leflunomide.
Anagrelide	Anagrelide The serum concentration of Anagrelide can be decreased when it is combined with Leflunomide.
Candesartan	Candesartan The metabolism of Candesartan can be decreased when combined with Leflunomide.
Cilostazol	Cilostazol The serum concentration of Cilostazol can be decreased when it is combined with Leflunomide.
Clopidogrel	Clopidogrel The serum concentration of Clopidogrel can be decreased when it is combined with Leflunomide.
Estrogen and Progestin (Oral Contraceptives)	Estrogen and Progestin (Oral Contraceptives) The serum concentration of Conjugated estrogens can be decreased when it is combined with Leflunomide.
Fenofibrate	Fenofibrate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Fenofibrate is combined with Leflunomide.
Mycophenolate	Mycophenolate The risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Leflunomide.
Nafarelin	Nafarelin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Nafarelin is combined with Leflunomide.
Prednisone	Prednisone The risk or severity of adverse effects can be increased when Prednisone is combined with Leflunomide.
Ranitidine	Ranitidine The serum concentration of Ranitidine can be decreased when it is combined with Leflunomide.
Tacrolimus	Tacrolimus Tacrolimus may increase the immunosuppressive activities of Leflunomide.
Tizanidine	Tizanidine The serum concentration of Tizanidine can be decreased when it is combined with Leflunomide.
Triamcinolone	Triamcinolone The risk or severity of adverse effects can be increased when Triamcinolone is combined with Leflunomide.
Zolmitriptan	Zolmitriptan The serum concentration of Zolmitriptan can be decreased when it is combined with Leflunomide.
Famotidine Injection	Famotidine Injection The metabolism of Leflunomide can be decreased when combined with Famotidine.
Fluconazole Injection	Fluconazole Injection The metabolism of Leflunomide can be decreased when combined with Fluconazole.
Hydromorphone Injection	Hydromorphone Injection The metabolism of Hydromorphone can be decreased when combined with Leflunomide.
Interferon Beta-1b Injection	Interferon Beta-1b Injection The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Leflunomide.
Interferon Gamma-1b Injection	Interferon Gamma-1b Injection The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Leflunomide.
Levofloxacin Injection	Levofloxacin Injection The metabolism of Leflunomide can be decreased when combined with Levofloxacin.
Meperidine Injection	Meperidine Injection The metabolism of Leflunomide can be increased when combined with Meperidine.
Methylprednisolone Injection	Methylprednisolone Injection The risk or severity of adverse effects can be increased when Methylprednisolone is combined with Leflunomide.
Metoclopramide Injection	Metoclopramide Injection The serum concentration of Metoclopramide can be decreased when it is combined with Leflunomide.
Metronidazole Injection	Metronidazole Injection The metabolism of Leflunomide can be decreased when combined with Metronidazole.
Pamidronate Injection	Pamidronate Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pamidronic acid is combined with Leflunomide.
Zidovudine Injection	Zidovudine Injection The risk or severity of adverse effects can be increased when Zidovudine is combined with Leflunomide.
Cyclosporine	Cyclosporine Leflunomide may increase the immunosuppressive activities of Cyclosporine.
Ondansetron	Ondansetron The metabolism of Leflunomide can be decreased when combined with Ondansetron.
Torsemide	Torsemide The metabolism of Leflunomide can be decreased when combined with Torasemide.
Olanzapine	Olanzapine The serum concentration of Olanzapine can be decreased when it is combined with Leflunomide.
Alosetron	Alosetron The serum concentration of Alosetron can be decreased when it is combined with Leflunomide.
Eprosartan	Eprosartan The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Eprosartan is combined with Leflunomide.
Hydroxychloroquine	Hydroxychloroquine The risk or severity of adverse effects can be increased when Hydroxychloroquine is combined with Leflunomide.
Meloxicam	Meloxicam The metabolism of Meloxicam can be decreased when combined with Leflunomide.
Pantoprazole	Pantoprazole Pantoprazole may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Risedronate	Risedronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Risedronic acid is combined with Leflunomide.
Sevelamer	Sevelamer Sevelamer may increase the excretion rate of Leflunomide which could result in a lower serum level and potentially a reduction in efficacy.
Telmisartan	Telmisartan Telmisartan may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Temozolomide	Temozolomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Leflunomide.
Anakinra	Anakinra The risk or severity of adverse effects can be increased when Anakinra is combined with Leflunomide.
Linezolid	Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Leflunomide.
Trimipramine	Trimipramine The metabolism of Trimipramine can be decreased when combined with Leflunomide.
Etanercept Injection	Etanercept Injection The risk or severity of adverse effects can be increased when Etanercept is combined with Leflunomide.
Modafinil	Modafinil The metabolism of Leflunomide can be decreased when combined with Modafinil.
Sirolimus	Sirolimus The risk or severity of adverse effects can be increased when Sirolimus is combined with Leflunomide.
Epinephrine Injection	Epinephrine Injection The metabolism of Leflunomide can be decreased when combined with Epinephrine.
Epirubicin	Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Leflunomide.
Adalimumab Injection	Adalimumab Injection The risk or severity of adverse effects can be increased when Adalimumab is combined with Leflunomide.
Glatiramer Injection	Glatiramer Injection The risk or severity of adverse effects can be increased when Glatiramer is combined with Leflunomide.
Atazanavir	Atazanavir The metabolism of Atazanavir can be decreased when combined with Leflunomide.
Eletriptan	Eletriptan The metabolism of Eletriptan can be decreased when combined with Leflunomide.
Mefloquine	Mefloquine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Mefloquine is combined with Leflunomide.
Rosuvastatin	Rosuvastatin The serum concentration of Rosuvastatin can be increased when it is combined with Leflunomide.
Aprepitant	Aprepitant The metabolism of Leflunomide can be decreased when combined with Aprepitant.
Interferon Beta-1a Subcutaneous Injection	Interferon Beta-1a Subcutaneous Injection The metabolism of Leflunomide can be decreased when combined with Interferon beta-1a.
Tegaserod	Tegaserod The metabolism of Leflunomide can be decreased when combined with Tegaserod.
Frovatriptan	Frovatriptan The serum concentration of Frovatriptan can be decreased when it is combined with Leflunomide.
Gemifloxacin	Gemifloxacin The metabolism of Leflunomide can be decreased when combined with Gemifloxacin.
Progesterone	Progesterone Progesterone may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Infliximab Injection	Infliximab Injection The risk or severity of adverse effects can be increased when Infliximab is combined with Leflunomide.
Oxandrolone	Oxandrolone The metabolism of Leflunomide can be decreased when combined with Oxandrolone.
Duloxetine	Duloxetine The serum concentration of Duloxetine can be decreased when it is combined with Leflunomide.
Bosentan	Bosentan The metabolism of Leflunomide can be increased when combined with Bosentan.
Cinacalcet	Cinacalcet The serum concentration of Cinacalcet can be decreased when it is combined with Leflunomide.
Natalizumab Injection	Natalizumab Injection The risk or severity of adverse effects can be increased when Leflunomide is combined with Natalizumab.
Erlotinib	Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Leflunomide.
Ganciclovir	Ganciclovir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Ganciclovir is combined with Leflunomide.
Voriconazole	Voriconazole The metabolism of Leflunomide can be decreased when combined with Voriconazole.
Entecavir	Entecavir The serum concentration of Entecavir can be decreased when it is combined with Leflunomide.
Peginterferon Alfa-2a Injection	Peginterferon Alfa-2a Injection The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Leflunomide.
Peginterferon Alfa-2b (PEG-Intron)	Peginterferon Alfa-2b (PEG-Intron) The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Leflunomide.
Ibandronate	Ibandronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Ibandronate is combined with Leflunomide.
Ramelteon	Ramelteon The serum concentration of Ramelteon can be decreased when it is combined with Leflunomide.
Deferasirox	Deferasirox The serum concentration of Leflunomide can be increased when it is combined with Deferasirox.
Phenylephrine	Phenylephrine The metabolism of Leflunomide can be increased when combined with Phenylephrine.
Felbamate	Felbamate The metabolism of Leflunomide can be decreased when combined with Felbamate.
Abatacept Injection	Abatacept Injection The risk or severity of adverse effects can be increased when Abatacept is combined with Leflunomide.
Rasagiline	Rasagiline The serum concentration of Rasagiline can be decreased when it is combined with Leflunomide.
Imatinib	Imatinib The risk or severity of adverse effects can be increased when Leflunomide is combined with Imatinib.
Bevacizumab Injection	Bevacizumab Injection The risk or severity of adverse effects can be increased when Bevacizumab is combined with Leflunomide.
Gefitinib	Gefitinib Gefitinib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Bortezomib	Bortezomib The risk or severity of adverse effects can be increased when Leflunomide is combined with Bortezomib.
Clofarabine Injection	Clofarabine Injection The risk or severity of adverse effects can be increased when Clofarabine is combined with Leflunomide.
Hepatitis B Vaccine	Hepatitis B Vaccine The therapeutic efficacy of Hepatitis B Vaccine (Recombinant) can be decreased when used in combination with Leflunomide.
Influenza Vaccine, Inactivated or Recombinant	Influenza Vaccine, Inactivated or Recombinant The therapeutic efficacy of Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Leflunomide.
Influenza Vaccine, Live Intranasal	Influenza Vaccine, Live Intranasal The risk or severity of infection can be increased when Typhoid Vaccine Live is combined with Leflunomide.
Live Shingles (Zoster) Vaccine (ZVL)	Live Shingles (Zoster) Vaccine (ZVL) The risk or severity of infection can be increased when Varicella Zoster Vaccine (Live/attenuated) is combined with Leflunomide.
Insulin Glulisine (rDNA origin) Injection	Insulin Glulisine (rDNA origin) Injection The metabolism of Leflunomide can be increased when combined with Insulin glulisine.
Oxaliplatin Injection	Oxaliplatin Injection The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Leflunomide.
Primaquine	Primaquine The serum concentration of Primaquine can be decreased when it is combined with Leflunomide.
Rituximab Injection	Rituximab Injection The risk or severity of adverse effects can be increased when Rituximab is combined with Leflunomide.
Pemetrexed Injection	Pemetrexed Injection The risk or severity of adverse effects can be increased when Leflunomide is combined with Pemetrexed.
Nabilone	Nabilone The metabolism of Leflunomide can be decreased when combined with Nabilone.
Vorinostat	Vorinostat The risk or severity of adverse effects can be increased when Vorinostat is combined with Leflunomide.
Sorafenib	Sorafenib The risk or severity of adverse effects can be increased when Leflunomide is combined with Sorafenib.
Sunitinib	Sunitinib The risk or severity of adverse effects can be increased when Sunitinib is combined with Leflunomide.
Dronabinol	Dronabinol Dronabinol may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Dasatinib	Dasatinib The risk or severity of adverse effects can be increased when Leflunomide is combined with Dasatinib.
Mexiletine	Mexiletine The serum concentration of Mexiletine can be decreased when it is combined with Leflunomide.
Armodafinil	Armodafinil The metabolism of Leflunomide can be decreased when combined with Armodafinil.
Azacitidine Injection	Azacitidine Injection The risk or severity of adverse effects can be increased when Azacitidine is combined with Leflunomide.
Ivermectin	Ivermectin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Ivermectin is combined with Leflunomide.
Temsirolimus	Temsirolimus The risk or severity of adverse effects can be increased when Temsirolimus is combined with Leflunomide.
Nelarabine Injection	Nelarabine Injection The risk or severity of adverse effects can be increased when Nelarabine is combined with Leflunomide.
Lenalidomide	Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Leflunomide.
Nilotinib	Nilotinib The risk or severity of adverse effects can be increased when Nilotinib is combined with Leflunomide.
Raltegravir	Raltegravir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Leflunomide is combined with Raltegravir.
Bexarotene	Bexarotene The risk or severity of adverse effects can be increased when Bexarotene is combined with Leflunomide.
Budesonide	Budesonide The risk or severity of adverse effects can be increased when Budesonide is combined with Leflunomide.
Chloramphenicol Injection	Chloramphenicol Injection The risk or severity of adverse effects can be increased when Chloramphenicol is combined with Leflunomide.
Decitabine Injection	Decitabine Injection The risk or severity of adverse effects can be increased when Decitabine is combined with Leflunomide.
Etravirine	Etravirine The metabolism of Etravirine can be decreased when combined with Leflunomide.
Arsenic Trioxide Injection	Arsenic Trioxide Injection The risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Leflunomide.
Mitoxantrone Injection	Mitoxantrone Injection The risk or severity of adverse effects can be increased when Mitoxantrone is combined with Leflunomide.
Tretinoin	Tretinoin The risk or severity of adverse effects can be increased when Tretinoin is combined with Leflunomide.
Bendamustine Injection	Bendamustine Injection The risk or severity of adverse effects can be increased when Leflunomide is combined with Bendamustine.
Flecainide	Flecainide The serum concentration of Leflunomide can be decreased when it is combined with Flecainide.
Certolizumab Injection	Certolizumab Injection The risk or severity of adverse effects can be increased when Certolizumab pegol is combined with Leflunomide.
Ixabepilone Injection	Ixabepilone Injection The risk or severity of adverse effects can be increased when Ixabepilone is combined with Leflunomide.
Irinotecan Injection	Irinotecan Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Leflunomide.
Daptomycin Injection	Daptomycin Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Leflunomide.
Estramustine	Estramustine The risk or severity of adverse effects can be increased when Estramustine is combined with Leflunomide.
Praziquantel	Praziquantel The serum concentration of Praziquantel can be decreased when it is combined with Leflunomide.
Alemtuzumab Injection (Chronic Lymphocytic Leukemia)	Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Leflunomide.
Naltrexone Injection	Naltrexone Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Leflunomide.
Dexrazoxane Injection	Dexrazoxane Injection The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Leflunomide.
Eltrombopag	Eltrombopag The serum concentration of Eltrombopag can be decreased when it is combined with Leflunomide.
Ibritumomab Injection	Ibritumomab Injection The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Leflunomide.
Betaxolol	Betaxolol The serum concentration of Betaxolol can be decreased when it is combined with Leflunomide.
Prasugrel	Prasugrel The metabolism of Prasugrel can be decreased when combined with Leflunomide.
Lacosamide	Lacosamide The metabolism of Lacosamide can be decreased when combined with Leflunomide.
Everolimus	Everolimus The risk or severity of adverse effects can be increased when Everolimus is combined with Leflunomide.
Pralatrexate Injection	Pralatrexate Injection The risk or severity of adverse effects can be increased when Pralatrexate is combined with Leflunomide.
Tapentadol	Tapentadol The metabolism of Tapentadol can be decreased when combined with Leflunomide.
Topotecan	Topotecan The risk or severity of adverse effects can be increased when Topotecan is combined with Leflunomide.
Golimumab Injection	Golimumab Injection The risk or severity of adverse effects can be increased when Golimumab is combined with Leflunomide.
Pazopanib	Pazopanib The risk or severity of adverse effects can be increased when Leflunomide is combined with Pazopanib.
Asenapine	Asenapine The serum concentration of Asenapine can be decreased when it is combined with Leflunomide.
Pitavastatin	Pitavastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Leflunomide is combined with Pitavastatin.
Albendazole	Albendazole The serum concentration of Albendazole can be decreased when it is combined with Leflunomide.
Denosumab Injection	Denosumab Injection The risk or severity of adverse effects can be increased when Denosumab is combined with Leflunomide.
Tocilizumab Injection	Tocilizumab Injection The risk or severity of adverse effects can be increased when Tocilizumab is combined with Leflunomide.
Fingolimod	Fingolimod Leflunomide may increase the immunosuppressive activities of Fingolimod.
Eribulin Injection	Eribulin Injection The risk or severity of adverse effects can be increased when Eribulin is combined with Leflunomide.
Cabazitaxel Injection	Cabazitaxel Injection The risk or severity of adverse effects can be increased when Cabazitaxel is combined with Leflunomide.
Acetaminophen Injection	Acetaminophen Injection The serum concentration of Acetaminophen can be decreased when it is combined with Leflunomide.
Denileukin Diftitox Injection	Denileukin Diftitox Injection The risk or severity of adverse effects can be increased when Aldesleukin is combined with Leflunomide.
Sipuleucel-T Injection	Sipuleucel-T Injection The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Leflunomide.
Belimumab Injection	Belimumab Injection The risk or severity of adverse effects can be increased when Belimumab is combined with Leflunomide.
Busulfan Injection	Busulfan Injection The risk or severity of adverse effects can be increased when Busulfan is combined with Leflunomide.
Roflumilast	Roflumilast Roflumilast may increase the immunosuppressive activities of Leflunomide.
Rilpivirine	Rilpivirine Rilpivirine may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Telaprevir	Telaprevir Glecaprevir may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Cyclophosphamide Injection	Cyclophosphamide Injection The risk or severity of adverse effects can be increased when Cyclophosphamide is combined with Leflunomide.
Abiraterone	Abiraterone The serum concentration of Leflunomide can be increased when it is combined with Abiraterone.
Ticagrelor	Ticagrelor The metabolism of Leflunomide can be decreased when combined with Ticagrelor.
Brentuximab Vedotin Injection	Brentuximab Vedotin Injection The risk or severity of adverse effects can be increased when Brentuximab vedotin is combined with Leflunomide.
Ruxolitinib	Ruxolitinib The risk or severity of adverse effects can be increased when Ruxolitinib is combined with Leflunomide.
Vandetanib	Vandetanib Vandetanib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Vemurafenib	Vemurafenib The serum concentration of Leflunomide can be increased when it is combined with Vemurafenib.
Vismodegib	Vismodegib Vismodegib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Belatacept Injection	Belatacept Injection The risk or severity of adverse effects can be increased when Belatacept is combined with Leflunomide.
Basiliximab Injection	Basiliximab Injection The risk or severity of adverse effects can be increased when Basiliximab is combined with Leflunomide.
Axitinib	Axitinib The serum concentration of Axitinib can be decreased when it is combined with Leflunomide.
Melphalan Injection	Melphalan Injection The risk or severity of adverse effects can be increased when Melphalan is combined with Leflunomide.
Eculizumab Injection	Eculizumab Injection The risk or severity of adverse effects can be increased when Eculizumab is combined with Leflunomide.
Carfilzomib Injection	Carfilzomib Injection The risk or severity of adverse effects can be increased when Carfilzomib is combined with Leflunomide.
Iloprost	Iloprost The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Iloprost is combined with Leflunomide.
Enzalutamide	Enzalutamide The metabolism of Leflunomide can be increased when combined with Enzalutamide.
Regorafenib	Regorafenib Regorafenib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Bosutinib	Bosutinib The risk or severity of adverse effects can be increased when Bosutinib is combined with Leflunomide.
Corticotropin, Repository Injection	Corticotropin, Repository Injection The risk or severity of adverse effects can be increased when Corticotropin is combined with Leflunomide.
Teriflunomide	Teriflunomide The risk or severity of adverse effects can be increased when Leflunomide is combined with Teriflunomide.
Cabozantinib (thyroid cancer)	Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Leflunomide.
Tofacitinib	Tofacitinib The risk or severity of adverse effects can be increased when Tofacitinib is combined with Leflunomide.
Dimethyl Fumarate	Dimethyl Fumarate The risk or severity of adverse effects can be increased when Dimethyl fumarate is combined with Leflunomide.
Ponatinib	Ponatinib The risk or severity of adverse effects can be increased when Ponatinib is combined with Leflunomide.
Pomalidomide	Pomalidomide The risk or severity of adverse effects can be increased when Leflunomide is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection	Ado-trastuzumab Emtansine Injection The risk or severity of adverse effects can be increased when Trastuzumab emtansine is combined with Leflunomide.
Apixaban	Apixaban The metabolism of Apixaban can be decreased when combined with Leflunomide.
Dabrafenib	Dabrafenib The metabolism of Leflunomide can be increased when combined with Dabrafenib.
Ospemifene	Ospemifene The metabolism of Ospemifene can be decreased when combined with Leflunomide.
Afatinib	Afatinib Afatinib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Vortioxetine	Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Leflunomide.
Perampanel	Perampanel The serum concentration of Perampanel can be decreased when it is combined with Leflunomide.
Ibrutinib	Ibrutinib The risk or severity of adverse effects can be increased when Ibrutinib is combined with Leflunomide.
Ketorolac Injection	Ketorolac Injection The metabolism of Ketorolac can be decreased when combined with Leflunomide.
Obinutuzumab Injection	Obinutuzumab Injection The risk or severity of adverse effects can be increased when Obinutuzumab is combined with Leflunomide.
Simeprevir	Simeprevir Simeprevir may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Dapagliflozin	Dapagliflozin The serum concentration of Dapagliflozin can be decreased when it is combined with Leflunomide.
Apremilast	Apremilast The risk or severity of adverse effects can be increased when Leflunomide is combined with Apremilast.
Ceritinib	Ceritinib The metabolism of Leflunomide can be decreased when combined with Ceritinib.
Siltuximab Injection	Siltuximab Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Leflunomide.
Vedolizumab Injection	Vedolizumab Injection The risk or severity of adverse effects can be increased when Vedolizumab is combined with Leflunomide.
Belinostat Injection	Belinostat Injection The risk or severity of adverse effects can be increased when Belinostat is combined with Leflunomide.
Idelalisib	Idelalisib The risk or severity of adverse effects can be increased when Idelalisib is combined with Leflunomide.
Testosterone Injection	Testosterone Injection The metabolism of Testosterone can be decreased when combined with Leflunomide.
Oritavancin Injection	Oritavancin Injection The metabolism of Leflunomide can be decreased when combined with Oritavancin.
Peginterferon Beta-1a Injection	Peginterferon Beta-1a Injection The risk or severity of adverse effects can be increased when Peginterferon beta-1a is combined with Leflunomide.
Olaparib	Olaparib The risk or severity of adverse effects can be increased when Olaparib is combined with Leflunomide.
Blinatumomab Injection	Blinatumomab Injection The risk or severity of adverse effects can be increased when Blinatumomab is combined with Leflunomide.
Tasimelteon	Tasimelteon The serum concentration of Tasimelteon can be decreased when it is combined with Leflunomide.
Pirfenidone	Pirfenidone The risk or severity of adverse effects can be increased when Leflunomide is combined with Pirfenidone.
Secukinumab Injection	Secukinumab Injection The risk or severity of adverse effects can be increased when Secukinumab is combined with Leflunomide.
Palbociclib	Palbociclib The risk or severity of adverse effects can be increased when Palbociclib is combined with Leflunomide.
Insulin Human Inhalation	Insulin Human Inhalation The metabolism of Leflunomide can be increased when combined with Insulin human.
Lenvatinib	Lenvatinib The metabolism of Leflunomide can be decreased when combined with Lenvatinib.
Panobinostat	Panobinostat The risk or severity of adverse effects can be increased when Panobinostat is combined with Leflunomide.
Dinutuximab Injection	Dinutuximab Injection The risk or severity of adverse effects can be increased when Dinutuximab is combined with Leflunomide.
Haloperidol Injection	Haloperidol Injection The serum concentration of Haloperidol can be decreased when it is combined with Leflunomide.
Rolapitant	Rolapitant Rolapitant may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Prednisolone	Prednisolone The risk or severity of adverse effects can be increased when Prednisolone is combined with Leflunomide.
Daclatasvir	Daclatasvir Daclatasvir may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Insulin Degludec (rDNA Origin) Injection	Insulin Degludec (rDNA Origin) Injection The metabolism of Leflunomide can be increased when combined with Insulin degludec.
Mepolizumab Injection	Mepolizumab Injection The risk or severity of adverse effects can be increased when Mepolizumab is combined with Leflunomide.
Trabectedin Injection	Trabectedin Injection The risk or severity of adverse effects can be increased when Trabectedin is combined with Leflunomide.
Osimertinib	Osimertinib The serum concentration of Leflunomide can be decreased when it is combined with Osimertinib.
Alectinib	Alectinib Alectinib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Lesinurad	Lesinurad The metabolism of Lesinurad can be decreased when combined with Leflunomide.
Amphotericin B Liposomal Injection	Amphotericin B Liposomal Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Amphotericin B is combined with Leflunomide.
Dexamethasone Injection	Dexamethasone Injection The risk or severity of adverse effects can be increased when Dexamethasone is combined with Leflunomide.
Ixekizumab Injection	Ixekizumab Injection The risk or severity of adverse effects can be increased when Ixekizumab is combined with Leflunomide.
Brivaracetam Injection	Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Leflunomide.
Venetoclax	Venetoclax Venetoclax may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Cobicistat	Cobicistat Cobicistat may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Obeticholic Acid	Obeticholic Acid The metabolism of Leflunomide can be decreased when combined with Obeticholic acid.
Diphenhydramine Injection	Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Leflunomide.
Rucaparib	Rucaparib The serum concentration of Rucaparib can be decreased when it is combined with Leflunomide.
Brodalumab Injection	Brodalumab Injection The risk or severity of adverse effects can be increased when Brodalumab is combined with Leflunomide.
Brigatinib	Brigatinib Brigatinib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Doxepin (Insomnia)	Doxepin (Insomnia) The serum concentration of Doxepin can be decreased when it is combined with Leflunomide.
Deflazacort	Deflazacort The risk or severity of adverse effects can be increased when Deflazacort is combined with Leflunomide.
Safinamide	Safinamide Safinamide may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Ocrelizumab Injection	Ocrelizumab Injection The risk or severity of adverse effects can be increased when Ocrelizumab is combined with Leflunomide.
Sarilumab Injection	Sarilumab Injection The risk or severity of adverse effects can be increased when Sarilumab is combined with Leflunomide.
Midostaurin	Midostaurin The metabolism of Leflunomide can be decreased when combined with Midostaurin.
Guselkumab Injection	Guselkumab Injection The risk or severity of adverse effects can be increased when Guselkumab is combined with Leflunomide.
Enasidenib	Enasidenib The serum concentration of Enasidenib can be decreased when it is combined with Leflunomide.
Delafloxacin	Delafloxacin The metabolism of Leflunomide can be increased when combined with Delafloxacin.
Abemaciclib	Abemaciclib Abemaciclib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Gemtuzumab Ozogamicin Injection	Gemtuzumab Ozogamicin Injection The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Leflunomide.
Letermovir	Letermovir Letermovir may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Buprenorphine Injection	Buprenorphine Injection Buprenorphine may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Apalutamide	Apalutamide Apalutamide may increase the excretion rate of Leflunomide which could result in a lower serum level and potentially a reduction in efficacy.
Penicillamine	Penicillamine The risk or severity of adverse effects can be increased when Penicillamine is combined with Leflunomide.
Fostamatinib	Fostamatinib Fostamatinib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Avatrombopag	Avatrombopag Avatrombopag may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Baricitinib	Baricitinib The risk or severity of adverse effects can be increased when Baricitinib is combined with Leflunomide.
Lofexidine	Lofexidine The serum concentration of Lofexidine can be decreased when it is combined with Leflunomide.
Binimetinib	Binimetinib The serum concentration of Binimetinib can be decreased when it is combined with Leflunomide.
Cannabidiol	Cannabidiol Cannabidiol may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Dacomitinib	Dacomitinib The metabolism of Leflunomide can be decreased when combined with Dacomitinib.
Stiripentol	Stiripentol The serum concentration of Stiripentol can be decreased when it is combined with Leflunomide.
Gilteritinib	Gilteritinib Gilteritinib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Glasdegib	Glasdegib Glasdegib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection The risk or severity of adverse effects can be increased when Paclitaxel is combined with Leflunomide.
Rifamycin	Rifamycin The metabolism of Leflunomide can be decreased when combined with Rifamycin.
Ravulizumab-cwvz Injection	Ravulizumab-cwvz Injection The risk or severity of adverse effects can be increased when Ravulizumab is combined with Leflunomide.
Emapalumab-lzsg Injection	Emapalumab-lzsg Injection The risk or severity of adverse effects can be increased when Emapalumab is combined with Leflunomide.
Siponimod	Siponimod The risk or severity of adverse effects can be increased when Siponimod is combined with Leflunomide.
Acyclovir Ophthalmic	Acyclovir Ophthalmic The serum concentration of Acyclovir can be decreased when it is combined with Leflunomide.
Erdafitinib	Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Leflunomide.
Risankizumab-rzaa Injection	Risankizumab-rzaa Injection The risk or severity of adverse effects can be increased when Risankizumab is combined with Leflunomide.
Alpelisib	Alpelisib The serum concentration of Leflunomide can be decreased when it is combined with Alpelisib.
Cladribine	Cladribine The risk or severity of adverse effects can be increased when Cladribine is combined with Leflunomide.
Darolutamide	Darolutamide The serum concentration of Leflunomide can be increased when it is combined with Darolutamide.
Triclabendazole	Triclabendazole The serum concentration of Triclabendazole can be decreased when it is combined with Leflunomide.
Istradefylline	Istradefylline The serum concentration of Istradefylline can be decreased when it is combined with Leflunomide.
Pitolisant	Pitolisant The metabolism of Leflunomide can be increased when combined with Pitolisant.
Fedratinib	Fedratinib Fedratinib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Phenytoin Injection	Phenytoin Injection The metabolism of Phenytoin can be decreased when combined with Leflunomide.
Fosphenytoin Injection	Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Leflunomide.
Voxelotor	Voxelotor The metabolism of Voxelotor can be decreased when combined with Leflunomide.
Avapritinib	Avapritinib The metabolism of Avapritinib can be decreased when combined with Leflunomide.
Lasmiditan	Lasmiditan The serum concentration of Leflunomide can be increased when it is combined with Lasmiditan.
Ozanimod	Ozanimod The risk or severity of adverse effects can be increased when Ozanimod is combined with Leflunomide.
Selumetinib	Selumetinib The serum concentration of Selumetinib can be decreased when it is combined with Leflunomide.
Ripretinib	Ripretinib Ripretinib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Capmatinib	Capmatinib The serum concentration of Leflunomide can be increased when it is combined with Capmatinib.
Fostemsavir	Fostemsavir Fostemsavir may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Pralsetinib	Pralsetinib Pralsetinib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Satralizumab-mwge Injection	Satralizumab-mwge Injection The serum concentration of Leflunomide can be decreased when it is combined with Satralizumab.
Viloxazine	Viloxazine The metabolism of Leflunomide can be decreased when combined with Viloxazine.
Theophylline	Theophylline The serum concentration of Theophylline can be decreased when it is combined with Leflunomide.
Indomethacin	Indomethacin The risk or severity of adverse effects can be increased when Indomethacin is combined with Leflunomide.
Mefenamic Acid	Mefenamic Acid The metabolism of Mefenamic acid can be decreased when combined with Leflunomide.
Naproxen	Naproxen The serum concentration of Naproxen can be decreased when it is combined with Leflunomide.
Isotretinoin	Isotretinoin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Isotretinoin is combined with Leflunomide.
Hydroxyurea	Hydroxyurea The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Leflunomide.
Floxuridine	Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Leflunomide.
Phenobarbital	Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Leflunomide.
Methotrexate Injection	Methotrexate Injection The risk or severity of adverse effects can be increased when Methotrexate is combined with Leflunomide.
Primidone	Primidone The metabolism of Leflunomide can be increased when combined with Primidone.
Chlorpromazine	Chlorpromazine The serum concentration of Chlorpromazine can be decreased when it is combined with Leflunomide.
Diazepam	Diazepam The metabolism of Diazepam can be decreased when combined with Leflunomide.
Carmustine	Carmustine The risk or severity of adverse effects can be increased when Leflunomide is combined with Carmustine.
Tranylcypromine	Tranylcypromine The metabolism of Leflunomide can be decreased when combined with Tranylcypromine.
Procarbazine	Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Leflunomide.
Thioguanine	Thioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Leflunomide.
Minocycline	Minocycline The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Minocycline is combined with Leflunomide.
Trifluoperazine	Trifluoperazine The serum concentration of Trifluoperazine can be decreased when it is combined with Leflunomide.
Bleomycin	Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Leflunomide.
Dapsone	Dapsone The metabolism of Dapsone can be decreased when combined with Leflunomide.
Sulfadiazine	Sulfadiazine The metabolism of Leflunomide can be decreased when combined with Sulfadiazine.
Methadone	Methadone The metabolism of Methadone can be decreased when combined with Leflunomide.
Colestipol	Colestipol Colestipol may increase the excretion rate of Leflunomide which could result in a lower serum level and potentially a reduction in efficacy.
Maprotiline	Maprotiline The serum concentration of Maprotiline can be decreased when it is combined with Leflunomide.
Ibuprofen	Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Leflunomide.
Orphenadrine	Orphenadrine The metabolism of Leflunomide can be decreased when combined with Orphenadrine.
Perphenazine	Perphenazine The serum concentration of Perphenazine can be decreased when it is combined with Leflunomide.
Azathioprine	Azathioprine The risk or severity of adverse effects can be increased when Leflunomide is combined with Azathioprine.
Sulfasalazine	Sulfasalazine The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Leflunomide.
Hydrocortisone	Hydrocortisone The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Leflunomide.
Lomustine	Lomustine The risk or severity of adverse effects can be increased when Lomustine is combined with Leflunomide.
Doxorubicin	Doxorubicin The risk or severity of adverse effects can be increased when Doxorubicin is combined with Leflunomide.
Cytarabine	Cytarabine The risk or severity of adverse effects can be increased when Cytarabine is combined with Leflunomide.
Mechlorethamine	Mechlorethamine The risk or severity of adverse effects can be increased when Mechlorethamine is combined with Leflunomide.
Dactinomycin	Dactinomycin The risk or severity of adverse effects can be increased when Dactinomycin is combined with Leflunomide.
Carbamazepine	Carbamazepine The risk or severity of adverse effects can be increased when Leflunomide is combined with Carbamazepine.
Methyldopa	Methyldopa The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Methyldopa is combined with Leflunomide.
Clonidine	Clonidine The serum concentration of Clonidine can be decreased when it is combined with Leflunomide.
Cimetidine	Cimetidine The metabolism of Leflunomide can be decreased when combined with Cimetidine.
Warfarin	Warfarin The serum concentration of Warfarin can be decreased when it is combined with Leflunomide.
Promethazine	Promethazine The metabolism of Leflunomide can be decreased when combined with Promethazine.
Daunorubicin	Daunorubicin The risk or severity of adverse effects can be increased when Daunorubicin is combined with Leflunomide.
Griseofulvin	Griseofulvin The metabolism of Leflunomide can be increased when combined with Griseofulvin.
Chloroquine	Chloroquine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Chloroquine is combined with Leflunomide.
Quinine	Quinine The serum concentration of Quinine can be decreased when it is combined with Leflunomide.
Triamterene	Triamterene The serum concentration of Triamterene can be decreased when it is combined with Leflunomide.
Sulfinpyrazone	Sulfinpyrazone The metabolism of Leflunomide can be decreased when combined with Sulfinpyrazone.
Secobarbital	Secobarbital The metabolism of Leflunomide can be increased when combined with Secobarbital.
Amitriptyline	Amitriptyline The serum concentration of Amitriptyline can be decreased when it is combined with Leflunomide.
Imipramine	Imipramine The serum concentration of Imipramine can be decreased when it is combined with Leflunomide.
Probenecid	Probenecid The metabolism of Leflunomide can be decreased when combined with Probenecid.
Quinidine	Quinidine The metabolism of Leflunomide can be decreased when combined with Quinidine.
Procainamide	Procainamide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Procainamide is combined with Leflunomide.
Isoniazid	Isoniazid The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Isoniazid is combined with Leflunomide.
Rifampin	Rifampin The serum concentration of teriflunomide (A77 1726), an active metabolite of Leflunomide, can be increased when used in combination with Rifampicin.
Disopyramide	Disopyramide The serum concentration of Disopyramide can be decreased when it is combined with Leflunomide.
Valproic Acid	Valproic Acid The metabolism of Leflunomide can be decreased when combined with Valproic acid.
Tamoxifen	Tamoxifen The serum concentration of Leflunomide can be decreased when it is combined with Tamoxifen.
Mitomycin	Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Leflunomide.
Methimazole	Methimazole The risk or severity of adverse effects can be increased when Methimazole is combined with Leflunomide.
Propylthiouracil	Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Leflunomide.
Chlorpropamide	Chlorpropamide The metabolism of Chlorpropamide can be decreased when combined with Leflunomide.
Tolbutamide	Tolbutamide The serum concentration of Tolbutamide can be increased when it is combined with Leflunomide.
Tolazamide	Tolazamide The metabolism of Tolazamide can be decreased when combined with Leflunomide.
Dextromethorphan	Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Leflunomide.
Cyclobenzaprine	Cyclobenzaprine The serum concentration of Cyclobenzaprine can be decreased when it is combined with Leflunomide.
Niacin	Niacin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Niacin is combined with Leflunomide.
Baclofen	Baclofen The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Baclofen is combined with Leflunomide.
Chlorzoxazone	Chlorzoxazone The serum concentration of Chlorzoxazone can be decreased when it is combined with Leflunomide.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) The serum concentration of Propranolol can be decreased when it is combined with Leflunomide.
Amphotericin B Injection	Amphotericin B Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Amphotericin B is combined with Leflunomide.
Mercaptopurine	Mercaptopurine The risk or severity of adverse effects can be increased when Mercaptopurine is combined with Leflunomide.
Cholestyramine Resin	Cholestyramine Resin Cholestyramine may increase the excretion rate of Leflunomide which could result in a lower serum level and potentially a reduction in efficacy.
Fluorouracil Injection	Fluorouracil Injection The risk or severity of adverse effects can be increased when Leflunomide is combined with Fluorouracil.
Colchicine	Colchicine The risk or severity of adverse effects can be increased when Colchicine is combined with Leflunomide.
Dacarbazine	Dacarbazine The risk or severity of adverse effects can be increased when Leflunomide is combined with Dacarbazine.
Bacillus Calmette-Guerin (BCG) Vaccine	Bacillus Calmette-Guerin (BCG) Vaccine The risk or severity of infection can be increased when Bacillus calmette-guerin substrain tice live antigen is combined with Leflunomide.
Ketoconazole	Ketoconazole The metabolism of Leflunomide can be decreased when combined with Ketoconazole.
Thiotepa Injection	Thiotepa Injection The risk or severity of adverse effects can be increased when Thiotepa is combined with Leflunomide.
Vincristine Injection	Vincristine Injection The risk or severity of adverse effects can be increased when Vincristine is combined with Leflunomide.
Captopril	Captopril The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Leflunomide is combined with Captopril.
Vinblastine	Vinblastine The risk or severity of adverse effects can be increased when Vinblastine is combined with Leflunomide.
Thiothixene	Thiothixene The serum concentration of Thiothixene can be decreased when it is combined with Leflunomide.
Aspirin	Aspirin The metabolism of Acetylsalicylic acid can be decreased when combined with Leflunomide.
Chlorambucil	Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Leflunomide.
Triazolam	Triazolam The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Triazolam is combined with Leflunomide.
Trimethoprim	Trimethoprim The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Leflunomide.
Diltiazem	Diltiazem The metabolism of Diltiazem can be decreased when combined with Leflunomide.
Nifedipine	Nifedipine The serum concentration of Nifedipine can be decreased when it is combined with Leflunomide.
Verapamil	Verapamil The serum concentration of Verapamil can be decreased when it is combined with Leflunomide.
Cisplatin Injection	Cisplatin Injection The risk or severity of adverse effects can be increased when Cisplatin is combined with Leflunomide.
Piroxicam	Piroxicam The metabolism of Piroxicam can be decreased when combined with Leflunomide.
Bumetanide	Bumetanide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Bumetanide is combined with Leflunomide.
Streptozocin	Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Leflunomide.
Etoposide	Etoposide The risk or severity of adverse effects can be increased when Leflunomide is combined with Etoposide.
Glyburide	Glyburide The metabolism of Leflunomide can be decreased when combined with Glyburide.
Glipizide	Glipizide The metabolism of Glipizide can be decreased when combined with Leflunomide.
Nafcillin Injection	Nafcillin Injection The metabolism of Leflunomide can be increased when combined with Nafcillin.
Pentoxifylline	Pentoxifylline The serum concentration of Pentoxifylline can be decreased when it is combined with Leflunomide.
Leuprolide Injection	Leuprolide Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Leuprolide is combined with Leflunomide.
Gemfibrozil	Gemfibrozil The metabolism of Leflunomide can be decreased when combined with Gemfibrozil.
Guanabenz	Guanabenz The serum concentration of Guanabenz can be decreased when it is combined with Leflunomide.
Pimozide	Pimozide The serum concentration of Pimozide can be decreased when it is combined with Leflunomide.
Enalapril	Enalapril The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Enalapril is combined with Leflunomide.
Flurbiprofen	Flurbiprofen The metabolism of Flurbiprofen can be decreased when combined with Leflunomide.
Amiodarone	Amiodarone The metabolism of Leflunomide can be decreased when combined with Amiodarone.
Lovastatin	Lovastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Leflunomide.
Ciprofloxacin	Ciprofloxacin The metabolism of Leflunomide can be decreased when combined with Ciprofloxacin.
Diclofenac	Diclofenac The serum concentration of Diclofenac can be decreased when it is combined with Leflunomide.
Fluoxetine	Fluoxetine The serum concentration of Fluoxetine can be decreased when it is combined with Leflunomide.
Interferon Alfa-2b Injection	Interferon Alfa-2b Injection The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Leflunomide.
Clozapine	Clozapine The serum concentration of Clozapine can be decreased when it is combined with Leflunomide.
Idarubicin	Idarubicin The risk or severity of adverse effects can be increased when Idarubicin is combined with Leflunomide.
Ofloxacin	Ofloxacin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Leflunomide is combined with Ofloxacin.
Fludarabine Injection	Fludarabine Injection The risk or severity of adverse effects can be increased when Fludarabine is combined with Leflunomide.
Pentostatin Injection	Pentostatin Injection The risk or severity of adverse effects can be increased when Pentostatin is combined with Leflunomide.
Etodolac	Etodolac The metabolism of Etodolac can be decreased when combined with Leflunomide.
Felodipine	Felodipine The metabolism of Leflunomide can be decreased when combined with Felodipine.
Nabumetone	Nabumetone The serum concentration of Nabumetone can be decreased when it is combined with Leflunomide.
Pravastatin	Pravastatin Pravastatin may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Simvastatin	Simvastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Leflunomide.
Teniposide Injection	Teniposide Injection The risk or severity of adverse effects can be increased when Teniposide is combined with Leflunomide.
Atovaquone	Atovaquone The metabolism of Leflunomide can be decreased when combined with Atovaquone.
Zolpidem	Zolpidem The serum concentration of Zolpidem can be decreased when it is combined with Leflunomide.
Doxazosin	Doxazosin The metabolism of Doxazosin can be decreased when combined with Leflunomide.
Omeprazole	Omeprazole Omeprazole may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Cisapride	Cisapride The metabolism of Leflunomide can be decreased when combined with Cisapride.
Fluvastatin	Fluvastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Fluvastatin is combined with Leflunomide.
Venlafaxine	Venlafaxine The metabolism of Venlafaxine can be decreased when combined with Leflunomide.
Nizatidine	Nizatidine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Nizatidine is combined with Leflunomide.
Stavudine	Stavudine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Stavudine is combined with Leflunomide.
Fluvoxamine	Fluvoxamine The serum concentration of Fluvoxamine can be decreased when it is combined with Leflunomide.
Losartan	Losartan The metabolism of Losartan can be decreased when combined with Leflunomide.
Vinorelbine Injection	Vinorelbine Injection The risk or severity of adverse effects can be increased when Vinorelbine is combined with Leflunomide.
Carboplatin Injection	Carboplatin Injection The risk or severity of adverse effects can be increased when Carboplatin is combined with Leflunomide.
Lansoprazole	Lansoprazole Lansoprazole may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Ifosfamide Injection	Ifosfamide Injection The risk or severity of adverse effects can be increased when Ifosfamide is combined with Leflunomide.
Pegaspargase Injection	Pegaspargase Injection The risk or severity of adverse effects can be increased when Pegaspargase is combined with Leflunomide.
Nicardipine	Nicardipine The metabolism of Leflunomide can be decreased when combined with Nicardipine.
Bupropion	Bupropion The metabolism of Bupropion can be decreased when combined with Leflunomide.
Ticlopidine	Ticlopidine The metabolism of Leflunomide can be decreased when combined with Ticlopidine.
Saquinavir	Saquinavir Saquinavir may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Lamivudine	Lamivudine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lamivudine is combined with Leflunomide.
Riluzole	Riluzole The serum concentration of Riluzole can be decreased when it is combined with Leflunomide.
Glimepiride	Glimepiride The metabolism of Glimepiride can be decreased when combined with Leflunomide.
Gemcitabine Injection	Gemcitabine Injection The risk or severity of adverse effects can be increased when Gemcitabine is combined with Leflunomide.
Indinavir	Indinavir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Indinavir is combined with Leflunomide.
Ritonavir	Ritonavir Ritonavir may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Docetaxel Injection	Docetaxel Injection The risk or severity of adverse effects can be increased when Docetaxel is combined with Leflunomide.
Clomipramine	Clomipramine The serum concentration of Clomipramine can be decreased when it is combined with Leflunomide.
Zafirlukast	Zafirlukast The metabolism of Leflunomide can be decreased when combined with Zafirlukast.
Mirtazapine	Mirtazapine The serum concentration of Mirtazapine can be decreased when it is combined with Leflunomide.
Zileuton	Zileuton The serum concentration of Zileuton can be decreased when it is combined with Leflunomide.
Valsartan	Valsartan The metabolism of Leflunomide can be decreased when combined with Valsartan.
Insulin Lispro Injection	Insulin Lispro Injection The metabolism of Leflunomide can be increased when combined with Insulin lispro.
Donepezil	Donepezil The metabolism of Donepezil can be decreased when combined with Leflunomide.
Nelfinavir	Nelfinavir Nelfinavir may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Carvedilol	Carvedilol The serum concentration of Carvedilol can be decreased when it is combined with Leflunomide.
Nilutamide	Nilutamide The metabolism of Leflunomide can be decreased when combined with Nilutamide.
Flutamide	Flutamide The serum concentration of Flutamide can be decreased when it is combined with Leflunomide.
Selegiline	Selegiline The serum concentration of Selegiline can be decreased when it is combined with Leflunomide.
Bicalutamide	Bicalutamide The metabolism of Leflunomide can be decreased when combined with Bicalutamide.
Sertraline	Sertraline The metabolism of Sertraline can be decreased when combined with Leflunomide.
Propafenone	Propafenone The serum concentration of Propafenone can be decreased when it is combined with Leflunomide.
Letrozole	Letrozole The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Letrozole is combined with Leflunomide.
Irbesartan	Irbesartan The metabolism of Irbesartan can be decreased when combined with Leflunomide.
Ropinirole	Ropinirole The serum concentration of Ropinirole can be decreased when it is combined with Leflunomide.
Tolcapone	Tolcapone The metabolism of Leflunomide can be decreased when combined with Tolcapone.
Citalopram	Citalopram The metabolism of Leflunomide can be decreased when combined with Citalopram.
Capecitabine	Capecitabine The risk or severity of adverse effects can be increased when Capecitabine is combined with Leflunomide.
Efavirenz	Efavirenz The serum concentration of Leflunomide can be decreased when it is combined with Efavirenz.
Sildenafil	Sildenafil The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Leflunomide.
Trastuzumab Injection	Trastuzumab Injection The risk or severity of adverse effects can be increased when Trastuzumab is combined with Leflunomide.
Celecoxib	Celecoxib The metabolism of Celecoxib can be decreased when combined with Leflunomide.
Rosiglitazone	Rosiglitazone The metabolism of Leflunomide can be decreased when combined with Rosiglitazone.
Tolterodine	Tolterodine The metabolism of Tolterodine can be decreased when combined with Leflunomide.
Thalidomide	Thalidomide The risk or severity of adverse effects can be increased when Thalidomide is combined with Leflunomide.
Colesevelam	Colesevelam Colesevelam may increase the excretion rate of Leflunomide which could result in a lower serum level and potentially a reduction in efficacy.
Nateglinide	Nateglinide The metabolism of Nateglinide can be decreased when combined with Leflunomide.
Rabeprazole	Rabeprazole Rabeprazole may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Terbinafine	Terbinafine The serum concentration of Terbinafine can be decreased when it is combined with Leflunomide.