Leflunomide

Generic name: Pronounced as (le floo' na mide)
Brand names
  • Arava®
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 08/15/2015

Do not take leflunomide if you are pregnant or plan to become pregnant. Leflunomide may harm the fetus. You should not begin taking leflunomide until you have taken a pregnancy test with negative results and your doctor tells you that you are not pregnant. You must use an effective method of birth control before you begin taking leflunomide, during your treatment with leflunomide, and for 2 years after treatment. If your period is late or you miss a period during treatment with leflunomide, call your doctor immediately. Talk to your doctor if you plan to become pregnant within 2 years after stopping treatment with leflunomide. Your doctor can prescribe a treatment that will help to remove this medication more quickly from your body.

Leflunomide may cause liver damage that can be life-threatening and even cause death. The risk for liver damage is greatest in people taking other medications known to cause liver damage, and in people who already have liver disease. Tell your doctor if you have or have ever had hepatitis or any other type of liver disease and if you if you drink or have ever drunk large amounts of alcohol. Tell your doctor and pharmacist if you are taking acetaminophen (Tylenol, in other over-the-counter products), aspirin and other nonsteroidal anti-inflammatory medications (NSAIDs such as ibuprofen [Advil, Motrin] and naproxen [Aleve, Naprosyn], cholesterol-lowering medications (statins), hydroxychloroquine, iron products, isoniazid (Laniazid, in Rifamate, in Rifater), methotrexate (Trexall), niacin (nicotinic acid), or rifampin (Rifadin, Rimactane, in Rifamate, in Rifater). If you experience any of the following symptoms, call your doctor immediately: nausea, extreme tiredness, unusual bleeding or bruising, lack of energy, loss of appetite, pain in the upper right part of the stomach, yellowing of the skin or eyes, dark-colored urine, or flu-like symptoms.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to leflunomide.

Talk to your doctor about the risks of taking leflunomide.

Leflunomide is used alone or in combination with other medications to treat rheumatoid arthritis (a condition in which the body attacks its own joints, causing pain, swelling, and loss of function). Leflunomide is in a class of medications called disease-modifying antirheumatic drugs (DMARDs). It works by decreasing inflammation and slowing the progress of the condition, which can help improve the physical activity of people with rheumatoid arthritis.

Leflunomide comes as a tablet to take by mouth. It is usually taken once a day. Your doctor may tell you to take a larger dose of leflunomide for the first 3 days of treatment. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take leflunomide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor may need to decrease your dose or stop treatment if you experience certain severe side effects. Be sure to tell your doctor how you are feeling during your treatment.

Leflunomide may help control the symptoms of your rheumatoid arthritis but does not cure it. Continue to take leflunomide even if you feel well. Do not stop taking leflunomide without talking to your doctor.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking leflunomide,

  • tell your doctor and pharmacist if you are allergic to leflunomide, teriflunomide (Aubagio), any other medications, or any of the ingredients in leflunomide tablets. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin Jantoven); cholestyramine (Prevalite); gold compounds such as auranofin (Ridaura); medications to treat cancer; other medications that suppress the immune system such as azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), and tacrolimus (Astagraf, Prograf); penicillamine (Cuprimine, Depen), and tolbutamide. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have or have ever had serious infections or if you frequently get infections, cancer or other conditions affecting the bone marrow or the immune system (including human immunodeficiency virus [HIV] and acquired immunodeficiency syndrome [AIDS]), diabetes, or kidney disease.

  • tell your doctor if you are breastfeeding. Do not breastfeed while you are taking leflunomide.

  • if you are planning to father a child, you should talk to your doctor about stopping leflunomide and receiving a treatment to help to remove this medication from your body more quickly.

  • ask your doctor about the safe use of alcoholic beverages while you are taking leflunomide.

  • Taking leflunomide may decrease your ability to fight infection. Tell your doctor if you have an infection now or if you have any signs of infection such as fever, cough, or flu-like symptoms. If you experience any of the following symptoms during your treatment with leflunomide, call your doctor: fever; sore throat; cough; flu-like symptoms; area of warm, red, swollen, or painful skin; painful, difficult, or frequent urination; or other signs of infection. Your treatment with leflunomide may need to be interrupted if you have an infection.

  • You may already be infected with tuberculosis (TB; a serious lung infection) but not have any symptoms of the disease. In this case, leflunomide may make your infection more serious and cause you to develop symptoms. Tell your doctor if you have or have ever had TB, if you have lived in or visited a country where TB is common, or if you have been around someone who has or has ever had TB. Before you begin your treatment with leflunomide, your doctor will perform a skin test to see if you have TB. If you do have TB, your doctor will treat this infection with antibiotics before you begin taking leflunomide.

  • do not have any vaccinations without talking to your doctor.

  • you should know that leflunomide may cause high blood pressure. You should have your blood pressure checked before starting treatment and regularly while you are taking this medication.

Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Leflunomide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • diarrhea

    • vomiting

    • heartburn

    • headache

    • dizziness

    • weight loss

    • back pain

    • muscle pain or weakness

    • pain, burning, numbness, or tingling in the hands or feet

    • hair loss

    • leg cramps

    • dry skin

  • Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS section, call your doctor immediately or get emergency medical treatment:

    • rash with or without a fever

    • hives

    • blisters or peeling of skin

    • mouth sores

    • itching

    • difficulty breathing

    • new or worsening cough

    • chest pain

    • pale skin

  • Receiving medications which suppress the immune system may increase the risk of developing certain types of cancer. An increase in cancers was not reported in clinical studies with leflunomide to date. Talk to your doctor about the risks of receiving leflunomide.

  • Leflunomide may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom) and light.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • diarrhea

  • stomach pain

  • extreme tiredness

  • weakness

  • pale skin

  • fast heartbeat

  • shortness of breath

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin The metabolism of Leflunomide can be decreased when combined with Moxifloxacin.
Repaglinide Repaglinide The serum concentration of Repaglinide can be increased when it is combined with Leflunomide.
Montelukast Montelukast The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Leflunomide.
Insulin Glargine (rDNA origin) Injection Insulin Glargine (rDNA origin) Injection The metabolism of Leflunomide can be increased when combined with Insulin glargine.
Delavirdine Delavirdine The metabolism of Leflunomide can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Leflunomide can be decreased when combined with Nevirapine.
Atorvastatin Atorvastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Atorvastatin is combined with Leflunomide.
Alendronate Alendronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Alendronic acid is combined with Leflunomide.
Aminophylline Aminophylline The serum concentration of Aminophylline can be decreased when it is combined with Leflunomide.
Anagrelide Anagrelide The serum concentration of Anagrelide can be decreased when it is combined with Leflunomide.
Candesartan Candesartan The metabolism of Candesartan can be decreased when combined with Leflunomide.
Cilostazol Cilostazol The serum concentration of Cilostazol can be decreased when it is combined with Leflunomide.
Clopidogrel Clopidogrel The serum concentration of Clopidogrel can be decreased when it is combined with Leflunomide.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The serum concentration of Conjugated estrogens can be decreased when it is combined with Leflunomide.
Fenofibrate Fenofibrate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Fenofibrate is combined with Leflunomide.
Mycophenolate Mycophenolate The risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Leflunomide.
Nafarelin Nafarelin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Nafarelin is combined with Leflunomide.
Prednisone Prednisone The risk or severity of adverse effects can be increased when Prednisone is combined with Leflunomide.
Ranitidine Ranitidine The serum concentration of Ranitidine can be decreased when it is combined with Leflunomide.
Tacrolimus Tacrolimus Tacrolimus may increase the immunosuppressive activities of Leflunomide.
Tizanidine Tizanidine The serum concentration of Tizanidine can be decreased when it is combined with Leflunomide.
Triamcinolone Triamcinolone The risk or severity of adverse effects can be increased when Triamcinolone is combined with Leflunomide.
Zolmitriptan Zolmitriptan The serum concentration of Zolmitriptan can be decreased when it is combined with Leflunomide.
Famotidine Injection Famotidine Injection The metabolism of Leflunomide can be decreased when combined with Famotidine.
Fluconazole Injection Fluconazole Injection The metabolism of Leflunomide can be decreased when combined with Fluconazole.
Hydromorphone Injection Hydromorphone Injection The metabolism of Hydromorphone can be decreased when combined with Leflunomide.
Interferon Beta-1b Injection Interferon Beta-1b Injection The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Leflunomide.
Interferon Gamma-1b Injection Interferon Gamma-1b Injection The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Leflunomide.
Levofloxacin Injection Levofloxacin Injection The metabolism of Leflunomide can be decreased when combined with Levofloxacin.
Meperidine Injection Meperidine Injection The metabolism of Leflunomide can be increased when combined with Meperidine.
Methylprednisolone Injection Methylprednisolone Injection The risk or severity of adverse effects can be increased when Methylprednisolone is combined with Leflunomide.
Metoclopramide Injection Metoclopramide Injection The serum concentration of Metoclopramide can be decreased when it is combined with Leflunomide.
Metronidazole Injection Metronidazole Injection The metabolism of Leflunomide can be decreased when combined with Metronidazole.
Pamidronate Injection Pamidronate Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pamidronic acid is combined with Leflunomide.
Zidovudine Injection Zidovudine Injection The risk or severity of adverse effects can be increased when Zidovudine is combined with Leflunomide.
Cyclosporine Cyclosporine Leflunomide may increase the immunosuppressive activities of Cyclosporine.
Ondansetron Ondansetron The metabolism of Leflunomide can be decreased when combined with Ondansetron.
Torsemide Torsemide The metabolism of Leflunomide can be decreased when combined with Torasemide.
Olanzapine Olanzapine The serum concentration of Olanzapine can be decreased when it is combined with Leflunomide.
Alosetron Alosetron The serum concentration of Alosetron can be decreased when it is combined with Leflunomide.
Eprosartan Eprosartan The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Eprosartan is combined with Leflunomide.
Hydroxychloroquine Hydroxychloroquine The risk or severity of adverse effects can be increased when Hydroxychloroquine is combined with Leflunomide.
Meloxicam Meloxicam The metabolism of Meloxicam can be decreased when combined with Leflunomide.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Risedronate Risedronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Risedronic acid is combined with Leflunomide.
Sevelamer Sevelamer Sevelamer may increase the excretion rate of Leflunomide which could result in a lower serum level and potentially a reduction in efficacy.
Telmisartan Telmisartan Telmisartan may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Temozolomide Temozolomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Leflunomide.
Anakinra Anakinra The risk or severity of adverse effects can be increased when Anakinra is combined with Leflunomide.
Linezolid Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Leflunomide.
Trimipramine Trimipramine The metabolism of Trimipramine can be decreased when combined with Leflunomide.
Etanercept Injection Etanercept Injection The risk or severity of adverse effects can be increased when Etanercept is combined with Leflunomide.
Modafinil Modafinil The metabolism of Leflunomide can be decreased when combined with Modafinil.
Sirolimus Sirolimus The risk or severity of adverse effects can be increased when Sirolimus is combined with Leflunomide.
Epinephrine Injection Epinephrine Injection The metabolism of Leflunomide can be decreased when combined with Epinephrine.
Epirubicin Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Leflunomide.
Adalimumab Injection Adalimumab Injection The risk or severity of adverse effects can be increased when Adalimumab is combined with Leflunomide.
Glatiramer Injection Glatiramer Injection The risk or severity of adverse effects can be increased when Glatiramer is combined with Leflunomide.
Atazanavir Atazanavir The metabolism of Atazanavir can be decreased when combined with Leflunomide.
Eletriptan Eletriptan The metabolism of Eletriptan can be decreased when combined with Leflunomide.
Mefloquine Mefloquine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Mefloquine is combined with Leflunomide.
Rosuvastatin Rosuvastatin The serum concentration of Rosuvastatin can be increased when it is combined with Leflunomide.
Aprepitant Aprepitant The metabolism of Leflunomide can be decreased when combined with Aprepitant.
Interferon Beta-1a Subcutaneous Injection Interferon Beta-1a Subcutaneous Injection The metabolism of Leflunomide can be decreased when combined with Interferon beta-1a.
Tegaserod Tegaserod The metabolism of Leflunomide can be decreased when combined with Tegaserod.
Frovatriptan Frovatriptan The serum concentration of Frovatriptan can be decreased when it is combined with Leflunomide.
Gemifloxacin Gemifloxacin The metabolism of Leflunomide can be decreased when combined with Gemifloxacin.
Progesterone Progesterone Progesterone may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Infliximab Injection Infliximab Injection The risk or severity of adverse effects can be increased when Infliximab is combined with Leflunomide.
Oxandrolone Oxandrolone The metabolism of Leflunomide can be decreased when combined with Oxandrolone.
Duloxetine Duloxetine The serum concentration of Duloxetine can be decreased when it is combined with Leflunomide.
Bosentan Bosentan The metabolism of Leflunomide can be increased when combined with Bosentan.
Cinacalcet Cinacalcet The serum concentration of Cinacalcet can be decreased when it is combined with Leflunomide.
Natalizumab Injection Natalizumab Injection The risk or severity of adverse effects can be increased when Leflunomide is combined with Natalizumab.
Erlotinib Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Leflunomide.
Ganciclovir Ganciclovir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Ganciclovir is combined with Leflunomide.
Voriconazole Voriconazole The metabolism of Leflunomide can be decreased when combined with Voriconazole.
Entecavir Entecavir The serum concentration of Entecavir can be decreased when it is combined with Leflunomide.
Peginterferon Alfa-2a Injection Peginterferon Alfa-2a Injection The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Leflunomide.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Leflunomide.
Ibandronate Ibandronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Ibandronate is combined with Leflunomide.
Ramelteon Ramelteon The serum concentration of Ramelteon can be decreased when it is combined with Leflunomide.
Deferasirox Deferasirox The serum concentration of Leflunomide can be increased when it is combined with Deferasirox.
Phenylephrine Phenylephrine The metabolism of Leflunomide can be increased when combined with Phenylephrine.
Felbamate Felbamate The metabolism of Leflunomide can be decreased when combined with Felbamate.
Abatacept Injection Abatacept Injection The risk or severity of adverse effects can be increased when Abatacept is combined with Leflunomide.
Rasagiline Rasagiline The serum concentration of Rasagiline can be decreased when it is combined with Leflunomide.
Imatinib Imatinib The risk or severity of adverse effects can be increased when Leflunomide is combined with Imatinib.
Bevacizumab Injection Bevacizumab Injection The risk or severity of adverse effects can be increased when Bevacizumab is combined with Leflunomide.
Gefitinib Gefitinib Gefitinib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Bortezomib Bortezomib The risk or severity of adverse effects can be increased when Leflunomide is combined with Bortezomib.
Clofarabine Injection Clofarabine Injection The risk or severity of adverse effects can be increased when Clofarabine is combined with Leflunomide.
Hepatitis B Vaccine Hepatitis B Vaccine The therapeutic efficacy of Hepatitis B Vaccine (Recombinant) can be decreased when used in combination with Leflunomide.
Influenza Vaccine, Inactivated or Recombinant Influenza Vaccine, Inactivated or Recombinant The therapeutic efficacy of Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Leflunomide.
Influenza Vaccine, Live Intranasal Influenza Vaccine, Live Intranasal The risk or severity of infection can be increased when Typhoid Vaccine Live is combined with Leflunomide.
Live Shingles (Zoster) Vaccine (ZVL) Live Shingles (Zoster) Vaccine (ZVL) The risk or severity of infection can be increased when Varicella Zoster Vaccine (Live/attenuated) is combined with Leflunomide.
Insulin Glulisine (rDNA origin) Injection Insulin Glulisine (rDNA origin) Injection The metabolism of Leflunomide can be increased when combined with Insulin glulisine.
Oxaliplatin Injection Oxaliplatin Injection The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Leflunomide.
Primaquine Primaquine The serum concentration of Primaquine can be decreased when it is combined with Leflunomide.
Rituximab Injection Rituximab Injection The risk or severity of adverse effects can be increased when Rituximab is combined with Leflunomide.
Pemetrexed Injection Pemetrexed Injection The risk or severity of adverse effects can be increased when Leflunomide is combined with Pemetrexed.
Nabilone Nabilone The metabolism of Leflunomide can be decreased when combined with Nabilone.
Vorinostat Vorinostat The risk or severity of adverse effects can be increased when Vorinostat is combined with Leflunomide.
Sorafenib Sorafenib The risk or severity of adverse effects can be increased when Leflunomide is combined with Sorafenib.
Sunitinib Sunitinib The risk or severity of adverse effects can be increased when Sunitinib is combined with Leflunomide.
Dronabinol Dronabinol Dronabinol may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Dasatinib Dasatinib The risk or severity of adverse effects can be increased when Leflunomide is combined with Dasatinib.
Mexiletine Mexiletine The serum concentration of Mexiletine can be decreased when it is combined with Leflunomide.
Armodafinil Armodafinil The metabolism of Leflunomide can be decreased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection The risk or severity of adverse effects can be increased when Azacitidine is combined with Leflunomide.
Ivermectin Ivermectin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Ivermectin is combined with Leflunomide.
Temsirolimus Temsirolimus The risk or severity of adverse effects can be increased when Temsirolimus is combined with Leflunomide.
Nelarabine Injection Nelarabine Injection The risk or severity of adverse effects can be increased when Nelarabine is combined with Leflunomide.
Lenalidomide Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Leflunomide.
Nilotinib Nilotinib The risk or severity of adverse effects can be increased when Nilotinib is combined with Leflunomide.
Raltegravir Raltegravir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Leflunomide is combined with Raltegravir.
Bexarotene Bexarotene The risk or severity of adverse effects can be increased when Bexarotene is combined with Leflunomide.
Budesonide Budesonide The risk or severity of adverse effects can be increased when Budesonide is combined with Leflunomide.
Chloramphenicol Injection Chloramphenicol Injection The risk or severity of adverse effects can be increased when Chloramphenicol is combined with Leflunomide.
Decitabine Injection Decitabine Injection The risk or severity of adverse effects can be increased when Decitabine is combined with Leflunomide.
Etravirine Etravirine The metabolism of Etravirine can be decreased when combined with Leflunomide.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Leflunomide.
Mitoxantrone Injection Mitoxantrone Injection The risk or severity of adverse effects can be increased when Mitoxantrone is combined with Leflunomide.
Tretinoin Tretinoin The risk or severity of adverse effects can be increased when Tretinoin is combined with Leflunomide.
Bendamustine Injection Bendamustine Injection The risk or severity of adverse effects can be increased when Leflunomide is combined with Bendamustine.
Flecainide Flecainide The serum concentration of Leflunomide can be decreased when it is combined with Flecainide.
Certolizumab Injection Certolizumab Injection The risk or severity of adverse effects can be increased when Certolizumab pegol is combined with Leflunomide.
Ixabepilone Injection Ixabepilone Injection The risk or severity of adverse effects can be increased when Ixabepilone is combined with Leflunomide.
Irinotecan Injection Irinotecan Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Leflunomide.
Daptomycin Injection Daptomycin Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Leflunomide.
Estramustine Estramustine The risk or severity of adverse effects can be increased when Estramustine is combined with Leflunomide.
Praziquantel Praziquantel The serum concentration of Praziquantel can be decreased when it is combined with Leflunomide.
Alemtuzumab Injection (Chronic Lymphocytic Leukemia) Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Leflunomide.
Naltrexone Injection Naltrexone Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Leflunomide.
Dexrazoxane Injection Dexrazoxane Injection The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Leflunomide.
Eltrombopag Eltrombopag The serum concentration of Eltrombopag can be decreased when it is combined with Leflunomide.
Ibritumomab Injection Ibritumomab Injection The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Leflunomide.
Betaxolol Betaxolol The serum concentration of Betaxolol can be decreased when it is combined with Leflunomide.
Prasugrel Prasugrel The metabolism of Prasugrel can be decreased when combined with Leflunomide.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Leflunomide.
Everolimus Everolimus The risk or severity of adverse effects can be increased when Everolimus is combined with Leflunomide.
Pralatrexate Injection Pralatrexate Injection The risk or severity of adverse effects can be increased when Pralatrexate is combined with Leflunomide.
Tapentadol Tapentadol The metabolism of Tapentadol can be decreased when combined with Leflunomide.
Topotecan Topotecan The risk or severity of adverse effects can be increased when Topotecan is combined with Leflunomide.
Golimumab Injection Golimumab Injection The risk or severity of adverse effects can be increased when Golimumab is combined with Leflunomide.
Pazopanib Pazopanib The risk or severity of adverse effects can be increased when Leflunomide is combined with Pazopanib.
Asenapine Asenapine The serum concentration of Asenapine can be decreased when it is combined with Leflunomide.
Pitavastatin Pitavastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Leflunomide is combined with Pitavastatin.
Albendazole Albendazole The serum concentration of Albendazole can be decreased when it is combined with Leflunomide.
Denosumab Injection Denosumab Injection The risk or severity of adverse effects can be increased when Denosumab is combined with Leflunomide.
Tocilizumab Injection Tocilizumab Injection The risk or severity of adverse effects can be increased when Tocilizumab is combined with Leflunomide.
Fingolimod Fingolimod Leflunomide may increase the immunosuppressive activities of Fingolimod.
Eribulin Injection Eribulin Injection The risk or severity of adverse effects can be increased when Eribulin is combined with Leflunomide.
Cabazitaxel Injection Cabazitaxel Injection The risk or severity of adverse effects can be increased when Cabazitaxel is combined with Leflunomide.
Acetaminophen Injection Acetaminophen Injection The serum concentration of Acetaminophen can be decreased when it is combined with Leflunomide.
Denileukin Diftitox Injection Denileukin Diftitox Injection The risk or severity of adverse effects can be increased when Aldesleukin is combined with Leflunomide.
Sipuleucel-T Injection Sipuleucel-T Injection The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Leflunomide.
Belimumab Injection Belimumab Injection The risk or severity of adverse effects can be increased when Belimumab is combined with Leflunomide.
Busulfan Injection Busulfan Injection The risk or severity of adverse effects can be increased when Busulfan is combined with Leflunomide.
Roflumilast Roflumilast Roflumilast may increase the immunosuppressive activities of Leflunomide.
Rilpivirine Rilpivirine Rilpivirine may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Telaprevir Telaprevir Glecaprevir may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Cyclophosphamide Injection Cyclophosphamide Injection The risk or severity of adverse effects can be increased when Cyclophosphamide is combined with Leflunomide.
Abiraterone Abiraterone The serum concentration of Leflunomide can be increased when it is combined with Abiraterone.
Ticagrelor Ticagrelor The metabolism of Leflunomide can be decreased when combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The risk or severity of adverse effects can be increased when Brentuximab vedotin is combined with Leflunomide.
Ruxolitinib Ruxolitinib The risk or severity of adverse effects can be increased when Ruxolitinib is combined with Leflunomide.
Vandetanib Vandetanib Vandetanib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Vemurafenib Vemurafenib The serum concentration of Leflunomide can be increased when it is combined with Vemurafenib.
Vismodegib Vismodegib Vismodegib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Belatacept Injection Belatacept Injection The risk or severity of adverse effects can be increased when Belatacept is combined with Leflunomide.
Basiliximab Injection Basiliximab Injection The risk or severity of adverse effects can be increased when Basiliximab is combined with Leflunomide.
Axitinib Axitinib The serum concentration of Axitinib can be decreased when it is combined with Leflunomide.
Melphalan Injection Melphalan Injection The risk or severity of adverse effects can be increased when Melphalan is combined with Leflunomide.
Eculizumab Injection Eculizumab Injection The risk or severity of adverse effects can be increased when Eculizumab is combined with Leflunomide.
Carfilzomib Injection Carfilzomib Injection The risk or severity of adverse effects can be increased when Carfilzomib is combined with Leflunomide.
Iloprost Iloprost The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Iloprost is combined with Leflunomide.
Enzalutamide Enzalutamide The metabolism of Leflunomide can be increased when combined with Enzalutamide.
Regorafenib Regorafenib Regorafenib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Bosutinib Bosutinib The risk or severity of adverse effects can be increased when Bosutinib is combined with Leflunomide.
Corticotropin, Repository Injection Corticotropin, Repository Injection The risk or severity of adverse effects can be increased when Corticotropin is combined with Leflunomide.
Teriflunomide Teriflunomide The risk or severity of adverse effects can be increased when Leflunomide is combined with Teriflunomide.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Leflunomide.
Tofacitinib Tofacitinib The risk or severity of adverse effects can be increased when Tofacitinib is combined with Leflunomide.
Dimethyl Fumarate Dimethyl Fumarate The risk or severity of adverse effects can be increased when Dimethyl fumarate is combined with Leflunomide.
Ponatinib Ponatinib The risk or severity of adverse effects can be increased when Ponatinib is combined with Leflunomide.
Pomalidomide Pomalidomide The risk or severity of adverse effects can be increased when Leflunomide is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The risk or severity of adverse effects can be increased when Trastuzumab emtansine is combined with Leflunomide.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Leflunomide.
Dabrafenib Dabrafenib The metabolism of Leflunomide can be increased when combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Leflunomide.
Afatinib Afatinib Afatinib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Leflunomide.
Perampanel Perampanel The serum concentration of Perampanel can be decreased when it is combined with Leflunomide.
Ibrutinib Ibrutinib The risk or severity of adverse effects can be increased when Ibrutinib is combined with Leflunomide.
Ketorolac Injection Ketorolac Injection The metabolism of Ketorolac can be decreased when combined with Leflunomide.
Obinutuzumab Injection Obinutuzumab Injection The risk or severity of adverse effects can be increased when Obinutuzumab is combined with Leflunomide.
Simeprevir Simeprevir Simeprevir may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Dapagliflozin Dapagliflozin The serum concentration of Dapagliflozin can be decreased when it is combined with Leflunomide.
Apremilast Apremilast The risk or severity of adverse effects can be increased when Leflunomide is combined with Apremilast.
Ceritinib Ceritinib The metabolism of Leflunomide can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The risk or severity of adverse effects can be increased when Siltuximab is combined with Leflunomide.
Vedolizumab Injection Vedolizumab Injection The risk or severity of adverse effects can be increased when Vedolizumab is combined with Leflunomide.
Belinostat Injection Belinostat Injection The risk or severity of adverse effects can be increased when Belinostat is combined with Leflunomide.
Idelalisib Idelalisib The risk or severity of adverse effects can be increased when Idelalisib is combined with Leflunomide.
Testosterone Injection Testosterone Injection The metabolism of Testosterone can be decreased when combined with Leflunomide.
Oritavancin Injection Oritavancin Injection The metabolism of Leflunomide can be decreased when combined with Oritavancin.
Peginterferon Beta-1a Injection Peginterferon Beta-1a Injection The risk or severity of adverse effects can be increased when Peginterferon beta-1a is combined with Leflunomide.
Olaparib Olaparib The risk or severity of adverse effects can be increased when Olaparib is combined with Leflunomide.
Blinatumomab Injection Blinatumomab Injection The risk or severity of adverse effects can be increased when Blinatumomab is combined with Leflunomide.
Tasimelteon Tasimelteon The serum concentration of Tasimelteon can be decreased when it is combined with Leflunomide.
Pirfenidone Pirfenidone The risk or severity of adverse effects can be increased when Leflunomide is combined with Pirfenidone.
Secukinumab Injection Secukinumab Injection The risk or severity of adverse effects can be increased when Secukinumab is combined with Leflunomide.
Palbociclib Palbociclib The risk or severity of adverse effects can be increased when Palbociclib is combined with Leflunomide.
Insulin Human Inhalation Insulin Human Inhalation The metabolism of Leflunomide can be increased when combined with Insulin human.
Lenvatinib Lenvatinib The metabolism of Leflunomide can be decreased when combined with Lenvatinib.
Panobinostat Panobinostat The risk or severity of adverse effects can be increased when Panobinostat is combined with Leflunomide.
Dinutuximab Injection Dinutuximab Injection The risk or severity of adverse effects can be increased when Dinutuximab is combined with Leflunomide.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be decreased when it is combined with Leflunomide.
Rolapitant Rolapitant Rolapitant may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Prednisolone Prednisolone The risk or severity of adverse effects can be increased when Prednisolone is combined with Leflunomide.
Daclatasvir Daclatasvir Daclatasvir may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Insulin Degludec (rDNA Origin) Injection Insulin Degludec (rDNA Origin) Injection The metabolism of Leflunomide can be increased when combined with Insulin degludec.
Mepolizumab Injection Mepolizumab Injection The risk or severity of adverse effects can be increased when Mepolizumab is combined with Leflunomide.
Trabectedin Injection Trabectedin Injection The risk or severity of adverse effects can be increased when Trabectedin is combined with Leflunomide.
Osimertinib Osimertinib The serum concentration of Leflunomide can be decreased when it is combined with Osimertinib.
Alectinib Alectinib Alectinib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Lesinurad Lesinurad The metabolism of Lesinurad can be decreased when combined with Leflunomide.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Amphotericin B is combined with Leflunomide.
Dexamethasone Injection Dexamethasone Injection The risk or severity of adverse effects can be increased when Dexamethasone is combined with Leflunomide.
Ixekizumab Injection Ixekizumab Injection The risk or severity of adverse effects can be increased when Ixekizumab is combined with Leflunomide.
Brivaracetam Injection Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Leflunomide.
Venetoclax Venetoclax Venetoclax may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Cobicistat Cobicistat Cobicistat may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Obeticholic Acid Obeticholic Acid The metabolism of Leflunomide can be decreased when combined with Obeticholic acid.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Leflunomide.
Rucaparib Rucaparib The serum concentration of Rucaparib can be decreased when it is combined with Leflunomide.
Brodalumab Injection Brodalumab Injection The risk or severity of adverse effects can be increased when Brodalumab is combined with Leflunomide.
Brigatinib Brigatinib Brigatinib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Doxepin (Insomnia) Doxepin (Insomnia) The serum concentration of Doxepin can be decreased when it is combined with Leflunomide.
Deflazacort Deflazacort The risk or severity of adverse effects can be increased when Deflazacort is combined with Leflunomide.
Safinamide Safinamide Safinamide may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Ocrelizumab Injection Ocrelizumab Injection The risk or severity of adverse effects can be increased when Ocrelizumab is combined with Leflunomide.
Sarilumab Injection Sarilumab Injection The risk or severity of adverse effects can be increased when Sarilumab is combined with Leflunomide.
Midostaurin Midostaurin The metabolism of Leflunomide can be decreased when combined with Midostaurin.
Guselkumab Injection Guselkumab Injection The risk or severity of adverse effects can be increased when Guselkumab is combined with Leflunomide.
Enasidenib Enasidenib The serum concentration of Enasidenib can be decreased when it is combined with Leflunomide.
Delafloxacin Delafloxacin The metabolism of Leflunomide can be increased when combined with Delafloxacin.
Abemaciclib Abemaciclib Abemaciclib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Gemtuzumab Ozogamicin Injection Gemtuzumab Ozogamicin Injection The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Leflunomide.
Letermovir Letermovir Letermovir may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Buprenorphine Injection Buprenorphine Injection Buprenorphine may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Apalutamide Apalutamide Apalutamide may increase the excretion rate of Leflunomide which could result in a lower serum level and potentially a reduction in efficacy.
Penicillamine Penicillamine The risk or severity of adverse effects can be increased when Penicillamine is combined with Leflunomide.
Fostamatinib Fostamatinib Fostamatinib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Avatrombopag Avatrombopag Avatrombopag may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Baricitinib Baricitinib The risk or severity of adverse effects can be increased when Baricitinib is combined with Leflunomide.
Lofexidine Lofexidine The serum concentration of Lofexidine can be decreased when it is combined with Leflunomide.
Binimetinib Binimetinib The serum concentration of Binimetinib can be decreased when it is combined with Leflunomide.
Cannabidiol Cannabidiol Cannabidiol may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Dacomitinib Dacomitinib The metabolism of Leflunomide can be decreased when combined with Dacomitinib.
Stiripentol Stiripentol The serum concentration of Stiripentol can be decreased when it is combined with Leflunomide.
Gilteritinib Gilteritinib Gilteritinib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Glasdegib Glasdegib Glasdegib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The risk or severity of adverse effects can be increased when Paclitaxel is combined with Leflunomide.
Rifamycin Rifamycin The metabolism of Leflunomide can be decreased when combined with Rifamycin.
Ravulizumab-cwvz Injection Ravulizumab-cwvz Injection The risk or severity of adverse effects can be increased when Ravulizumab is combined with Leflunomide.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The risk or severity of adverse effects can be increased when Emapalumab is combined with Leflunomide.
Siponimod Siponimod The risk or severity of adverse effects can be increased when Siponimod is combined with Leflunomide.
Acyclovir Ophthalmic Acyclovir Ophthalmic The serum concentration of Acyclovir can be decreased when it is combined with Leflunomide.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Leflunomide.
Risankizumab-rzaa Injection Risankizumab-rzaa Injection The risk or severity of adverse effects can be increased when Risankizumab is combined with Leflunomide.
Alpelisib Alpelisib The serum concentration of Leflunomide can be decreased when it is combined with Alpelisib.
Cladribine Cladribine The risk or severity of adverse effects can be increased when Cladribine is combined with Leflunomide.
Darolutamide Darolutamide The serum concentration of Leflunomide can be increased when it is combined with Darolutamide.
Triclabendazole Triclabendazole The serum concentration of Triclabendazole can be decreased when it is combined with Leflunomide.
Istradefylline Istradefylline The serum concentration of Istradefylline can be decreased when it is combined with Leflunomide.
Pitolisant Pitolisant The metabolism of Leflunomide can be increased when combined with Pitolisant.
Fedratinib Fedratinib Fedratinib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Phenytoin Injection Phenytoin Injection The metabolism of Phenytoin can be decreased when combined with Leflunomide.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Leflunomide.
Voxelotor Voxelotor The metabolism of Voxelotor can be decreased when combined with Leflunomide.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Leflunomide.
Lasmiditan Lasmiditan The serum concentration of Leflunomide can be increased when it is combined with Lasmiditan.
Ozanimod Ozanimod The risk or severity of adverse effects can be increased when Ozanimod is combined with Leflunomide.
Selumetinib Selumetinib The serum concentration of Selumetinib can be decreased when it is combined with Leflunomide.
Ripretinib Ripretinib Ripretinib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Capmatinib Capmatinib The serum concentration of Leflunomide can be increased when it is combined with Capmatinib.
Fostemsavir Fostemsavir Fostemsavir may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Pralsetinib Pralsetinib Pralsetinib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Leflunomide can be decreased when it is combined with Satralizumab.
Viloxazine Viloxazine The metabolism of Leflunomide can be decreased when combined with Viloxazine.
Theophylline Theophylline The serum concentration of Theophylline can be decreased when it is combined with Leflunomide.
Indomethacin Indomethacin The risk or severity of adverse effects can be increased when Indomethacin is combined with Leflunomide.
Mefenamic Acid Mefenamic Acid The metabolism of Mefenamic acid can be decreased when combined with Leflunomide.
Naproxen Naproxen The serum concentration of Naproxen can be decreased when it is combined with Leflunomide.
Isotretinoin Isotretinoin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Isotretinoin is combined with Leflunomide.
Hydroxyurea Hydroxyurea The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Leflunomide.
Floxuridine Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Leflunomide.
Phenobarbital Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Leflunomide.
Methotrexate Injection Methotrexate Injection The risk or severity of adverse effects can be increased when Methotrexate is combined with Leflunomide.
Primidone Primidone The metabolism of Leflunomide can be increased when combined with Primidone.
Chlorpromazine Chlorpromazine The serum concentration of Chlorpromazine can be decreased when it is combined with Leflunomide.
Diazepam Diazepam The metabolism of Diazepam can be decreased when combined with Leflunomide.
Carmustine Carmustine The risk or severity of adverse effects can be increased when Leflunomide is combined with Carmustine.
Tranylcypromine Tranylcypromine The metabolism of Leflunomide can be decreased when combined with Tranylcypromine.
Procarbazine Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Leflunomide.
Thioguanine Thioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Leflunomide.
Minocycline Minocycline The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Minocycline is combined with Leflunomide.
Trifluoperazine Trifluoperazine The serum concentration of Trifluoperazine can be decreased when it is combined with Leflunomide.
Bleomycin Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Leflunomide.
Dapsone Dapsone The metabolism of Dapsone can be decreased when combined with Leflunomide.
Sulfadiazine Sulfadiazine The metabolism of Leflunomide can be decreased when combined with Sulfadiazine.
Methadone Methadone The metabolism of Methadone can be decreased when combined with Leflunomide.
Colestipol Colestipol Colestipol may increase the excretion rate of Leflunomide which could result in a lower serum level and potentially a reduction in efficacy.
Maprotiline Maprotiline The serum concentration of Maprotiline can be decreased when it is combined with Leflunomide.
Ibuprofen Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Leflunomide.
Orphenadrine Orphenadrine The metabolism of Leflunomide can be decreased when combined with Orphenadrine.
Perphenazine Perphenazine The serum concentration of Perphenazine can be decreased when it is combined with Leflunomide.
Azathioprine Azathioprine The risk or severity of adverse effects can be increased when Leflunomide is combined with Azathioprine.
Sulfasalazine Sulfasalazine The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Leflunomide.
Hydrocortisone Hydrocortisone The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Leflunomide.
Lomustine Lomustine The risk or severity of adverse effects can be increased when Lomustine is combined with Leflunomide.
Doxorubicin Doxorubicin The risk or severity of adverse effects can be increased when Doxorubicin is combined with Leflunomide.
Cytarabine Cytarabine The risk or severity of adverse effects can be increased when Cytarabine is combined with Leflunomide.
Mechlorethamine Mechlorethamine The risk or severity of adverse effects can be increased when Mechlorethamine is combined with Leflunomide.
Dactinomycin Dactinomycin The risk or severity of adverse effects can be increased when Dactinomycin is combined with Leflunomide.
Carbamazepine Carbamazepine The risk or severity of adverse effects can be increased when Leflunomide is combined with Carbamazepine.
Methyldopa Methyldopa The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Methyldopa is combined with Leflunomide.
Clonidine Clonidine The serum concentration of Clonidine can be decreased when it is combined with Leflunomide.
Cimetidine Cimetidine The metabolism of Leflunomide can be decreased when combined with Cimetidine.
Warfarin Warfarin The serum concentration of Warfarin can be decreased when it is combined with Leflunomide.
Promethazine Promethazine The metabolism of Leflunomide can be decreased when combined with Promethazine.
Daunorubicin Daunorubicin The risk or severity of adverse effects can be increased when Daunorubicin is combined with Leflunomide.
Griseofulvin Griseofulvin The metabolism of Leflunomide can be increased when combined with Griseofulvin.
Chloroquine Chloroquine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Chloroquine is combined with Leflunomide.
Quinine Quinine The serum concentration of Quinine can be decreased when it is combined with Leflunomide.
Triamterene Triamterene The serum concentration of Triamterene can be decreased when it is combined with Leflunomide.
Sulfinpyrazone Sulfinpyrazone The metabolism of Leflunomide can be decreased when combined with Sulfinpyrazone.
Secobarbital Secobarbital The metabolism of Leflunomide can be increased when combined with Secobarbital.
Amitriptyline Amitriptyline The serum concentration of Amitriptyline can be decreased when it is combined with Leflunomide.
Imipramine Imipramine The serum concentration of Imipramine can be decreased when it is combined with Leflunomide.
Probenecid Probenecid The metabolism of Leflunomide can be decreased when combined with Probenecid.
Quinidine Quinidine The metabolism of Leflunomide can be decreased when combined with Quinidine.
Procainamide Procainamide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Procainamide is combined with Leflunomide.
Isoniazid Isoniazid The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Isoniazid is combined with Leflunomide.
Rifampin Rifampin The serum concentration of teriflunomide (A77 1726), an active metabolite of Leflunomide, can be increased when used in combination with Rifampicin.
Disopyramide Disopyramide The serum concentration of Disopyramide can be decreased when it is combined with Leflunomide.
Valproic Acid Valproic Acid The metabolism of Leflunomide can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The serum concentration of Leflunomide can be decreased when it is combined with Tamoxifen.
Mitomycin Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Leflunomide.
Methimazole Methimazole The risk or severity of adverse effects can be increased when Methimazole is combined with Leflunomide.
Propylthiouracil Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Leflunomide.
Chlorpropamide Chlorpropamide The metabolism of Chlorpropamide can be decreased when combined with Leflunomide.
Tolbutamide Tolbutamide The serum concentration of Tolbutamide can be increased when it is combined with Leflunomide.
Tolazamide Tolazamide The metabolism of Tolazamide can be decreased when combined with Leflunomide.
Dextromethorphan Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Leflunomide.
Cyclobenzaprine Cyclobenzaprine The serum concentration of Cyclobenzaprine can be decreased when it is combined with Leflunomide.
Niacin Niacin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Niacin is combined with Leflunomide.
Baclofen Baclofen The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Baclofen is combined with Leflunomide.
Chlorzoxazone Chlorzoxazone The serum concentration of Chlorzoxazone can be decreased when it is combined with Leflunomide.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The serum concentration of Propranolol can be decreased when it is combined with Leflunomide.
Amphotericin B Injection Amphotericin B Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Amphotericin B is combined with Leflunomide.
Mercaptopurine Mercaptopurine The risk or severity of adverse effects can be increased when Mercaptopurine is combined with Leflunomide.
Cholestyramine Resin Cholestyramine Resin Cholestyramine may increase the excretion rate of Leflunomide which could result in a lower serum level and potentially a reduction in efficacy.
Fluorouracil Injection Fluorouracil Injection The risk or severity of adverse effects can be increased when Leflunomide is combined with Fluorouracil.
Colchicine Colchicine The risk or severity of adverse effects can be increased when Colchicine is combined with Leflunomide.
Dacarbazine Dacarbazine The risk or severity of adverse effects can be increased when Leflunomide is combined with Dacarbazine.
Bacillus Calmette-Guerin (BCG) Vaccine Bacillus Calmette-Guerin (BCG) Vaccine The risk or severity of infection can be increased when Bacillus calmette-guerin substrain tice live antigen is combined with Leflunomide.
Ketoconazole Ketoconazole The metabolism of Leflunomide can be decreased when combined with Ketoconazole.
Thiotepa Injection Thiotepa Injection The risk or severity of adverse effects can be increased when Thiotepa is combined with Leflunomide.
Vincristine Injection Vincristine Injection The risk or severity of adverse effects can be increased when Vincristine is combined with Leflunomide.
Captopril Captopril The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Leflunomide is combined with Captopril.
Vinblastine Vinblastine The risk or severity of adverse effects can be increased when Vinblastine is combined with Leflunomide.
Thiothixene Thiothixene The serum concentration of Thiothixene can be decreased when it is combined with Leflunomide.
Aspirin Aspirin The metabolism of Acetylsalicylic acid can be decreased when combined with Leflunomide.
Chlorambucil Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Leflunomide.
Triazolam Triazolam The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Triazolam is combined with Leflunomide.
Trimethoprim Trimethoprim The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Leflunomide.
Diltiazem Diltiazem The metabolism of Diltiazem can be decreased when combined with Leflunomide.
Nifedipine Nifedipine The serum concentration of Nifedipine can be decreased when it is combined with Leflunomide.
Verapamil Verapamil The serum concentration of Verapamil can be decreased when it is combined with Leflunomide.
Cisplatin Injection Cisplatin Injection The risk or severity of adverse effects can be increased when Cisplatin is combined with Leflunomide.
Piroxicam Piroxicam The metabolism of Piroxicam can be decreased when combined with Leflunomide.
Bumetanide Bumetanide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Bumetanide is combined with Leflunomide.
Streptozocin Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Leflunomide.
Etoposide Etoposide The risk or severity of adverse effects can be increased when Leflunomide is combined with Etoposide.
Glyburide Glyburide The metabolism of Leflunomide can be decreased when combined with Glyburide.
Glipizide Glipizide The metabolism of Glipizide can be decreased when combined with Leflunomide.
Nafcillin Injection Nafcillin Injection The metabolism of Leflunomide can be increased when combined with Nafcillin.
Pentoxifylline Pentoxifylline The serum concentration of Pentoxifylline can be decreased when it is combined with Leflunomide.
Leuprolide Injection Leuprolide Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Leuprolide is combined with Leflunomide.
Gemfibrozil Gemfibrozil The metabolism of Leflunomide can be decreased when combined with Gemfibrozil.
Guanabenz Guanabenz The serum concentration of Guanabenz can be decreased when it is combined with Leflunomide.
Pimozide Pimozide The serum concentration of Pimozide can be decreased when it is combined with Leflunomide.
Enalapril Enalapril The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Enalapril is combined with Leflunomide.
Flurbiprofen Flurbiprofen The metabolism of Flurbiprofen can be decreased when combined with Leflunomide.
Amiodarone Amiodarone The metabolism of Leflunomide can be decreased when combined with Amiodarone.
Lovastatin Lovastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Leflunomide.
Ciprofloxacin Ciprofloxacin The metabolism of Leflunomide can be decreased when combined with Ciprofloxacin.
Diclofenac Diclofenac The serum concentration of Diclofenac can be decreased when it is combined with Leflunomide.
Fluoxetine Fluoxetine The serum concentration of Fluoxetine can be decreased when it is combined with Leflunomide.
Interferon Alfa-2b Injection Interferon Alfa-2b Injection The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Leflunomide.
Clozapine Clozapine The serum concentration of Clozapine can be decreased when it is combined with Leflunomide.
Idarubicin Idarubicin The risk or severity of adverse effects can be increased when Idarubicin is combined with Leflunomide.
Ofloxacin Ofloxacin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Leflunomide is combined with Ofloxacin.
Fludarabine Injection Fludarabine Injection The risk or severity of adverse effects can be increased when Fludarabine is combined with Leflunomide.
Pentostatin Injection Pentostatin Injection The risk or severity of adverse effects can be increased when Pentostatin is combined with Leflunomide.
Etodolac Etodolac The metabolism of Etodolac can be decreased when combined with Leflunomide.
Felodipine Felodipine The metabolism of Leflunomide can be decreased when combined with Felodipine.
Nabumetone Nabumetone The serum concentration of Nabumetone can be decreased when it is combined with Leflunomide.
Pravastatin Pravastatin Pravastatin may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Simvastatin Simvastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Leflunomide.
Teniposide Injection Teniposide Injection The risk or severity of adverse effects can be increased when Teniposide is combined with Leflunomide.
Atovaquone Atovaquone The metabolism of Leflunomide can be decreased when combined with Atovaquone.
Zolpidem Zolpidem The serum concentration of Zolpidem can be decreased when it is combined with Leflunomide.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Leflunomide.
Omeprazole Omeprazole Omeprazole may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Cisapride Cisapride The metabolism of Leflunomide can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Fluvastatin is combined with Leflunomide.
Venlafaxine Venlafaxine The metabolism of Venlafaxine can be decreased when combined with Leflunomide.
Nizatidine Nizatidine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Nizatidine is combined with Leflunomide.
Stavudine Stavudine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Stavudine is combined with Leflunomide.
Fluvoxamine Fluvoxamine The serum concentration of Fluvoxamine can be decreased when it is combined with Leflunomide.
Losartan Losartan The metabolism of Losartan can be decreased when combined with Leflunomide.
Vinorelbine Injection Vinorelbine Injection The risk or severity of adverse effects can be increased when Vinorelbine is combined with Leflunomide.
Carboplatin Injection Carboplatin Injection The risk or severity of adverse effects can be increased when Carboplatin is combined with Leflunomide.
Lansoprazole Lansoprazole Lansoprazole may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Ifosfamide Injection Ifosfamide Injection The risk or severity of adverse effects can be increased when Ifosfamide is combined with Leflunomide.
Pegaspargase Injection Pegaspargase Injection The risk or severity of adverse effects can be increased when Pegaspargase is combined with Leflunomide.
Nicardipine Nicardipine The metabolism of Leflunomide can be decreased when combined with Nicardipine.
Bupropion Bupropion The metabolism of Bupropion can be decreased when combined with Leflunomide.
Ticlopidine Ticlopidine The metabolism of Leflunomide can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir Saquinavir may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Lamivudine Lamivudine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lamivudine is combined with Leflunomide.
Riluzole Riluzole The serum concentration of Riluzole can be decreased when it is combined with Leflunomide.
Glimepiride Glimepiride The metabolism of Glimepiride can be decreased when combined with Leflunomide.
Gemcitabine Injection Gemcitabine Injection The risk or severity of adverse effects can be increased when Gemcitabine is combined with Leflunomide.
Indinavir Indinavir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Indinavir is combined with Leflunomide.
Ritonavir Ritonavir Ritonavir may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Docetaxel Injection Docetaxel Injection The risk or severity of adverse effects can be increased when Docetaxel is combined with Leflunomide.
Clomipramine Clomipramine The serum concentration of Clomipramine can be decreased when it is combined with Leflunomide.
Zafirlukast Zafirlukast The metabolism of Leflunomide can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine The serum concentration of Mirtazapine can be decreased when it is combined with Leflunomide.
Zileuton Zileuton The serum concentration of Zileuton can be decreased when it is combined with Leflunomide.
Valsartan Valsartan The metabolism of Leflunomide can be decreased when combined with Valsartan.
Insulin Lispro Injection Insulin Lispro Injection The metabolism of Leflunomide can be increased when combined with Insulin lispro.
Donepezil Donepezil The metabolism of Donepezil can be decreased when combined with Leflunomide.
Nelfinavir Nelfinavir Nelfinavir may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Carvedilol Carvedilol The serum concentration of Carvedilol can be decreased when it is combined with Leflunomide.
Nilutamide Nilutamide The metabolism of Leflunomide can be decreased when combined with Nilutamide.
Flutamide Flutamide The serum concentration of Flutamide can be decreased when it is combined with Leflunomide.
Selegiline Selegiline The serum concentration of Selegiline can be decreased when it is combined with Leflunomide.
Bicalutamide Bicalutamide The metabolism of Leflunomide can be decreased when combined with Bicalutamide.
Sertraline Sertraline The metabolism of Sertraline can be decreased when combined with Leflunomide.
Propafenone Propafenone The serum concentration of Propafenone can be decreased when it is combined with Leflunomide.
Letrozole Letrozole The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Letrozole is combined with Leflunomide.
Irbesartan Irbesartan The metabolism of Irbesartan can be decreased when combined with Leflunomide.
Ropinirole Ropinirole The serum concentration of Ropinirole can be decreased when it is combined with Leflunomide.
Tolcapone Tolcapone The metabolism of Leflunomide can be decreased when combined with Tolcapone.
Citalopram Citalopram The metabolism of Leflunomide can be decreased when combined with Citalopram.
Capecitabine Capecitabine The risk or severity of adverse effects can be increased when Capecitabine is combined with Leflunomide.
Efavirenz Efavirenz The serum concentration of Leflunomide can be decreased when it is combined with Efavirenz.
Sildenafil Sildenafil The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Leflunomide.
Trastuzumab Injection Trastuzumab Injection The risk or severity of adverse effects can be increased when Trastuzumab is combined with Leflunomide.
Celecoxib Celecoxib The metabolism of Celecoxib can be decreased when combined with Leflunomide.
Rosiglitazone Rosiglitazone The metabolism of Leflunomide can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine The metabolism of Tolterodine can be decreased when combined with Leflunomide.
Thalidomide Thalidomide The risk or severity of adverse effects can be increased when Thalidomide is combined with Leflunomide.
Colesevelam Colesevelam Colesevelam may increase the excretion rate of Leflunomide which could result in a lower serum level and potentially a reduction in efficacy.
Nateglinide Nateglinide The metabolism of Nateglinide can be decreased when combined with Leflunomide.
Rabeprazole Rabeprazole Rabeprazole may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Terbinafine Terbinafine The serum concentration of Terbinafine can be decreased when it is combined with Leflunomide.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists