Lion's Mane With Cymbalta, Gabapentin And Primidone

Quick Answer

There is no known interaction between Lion's Mane mushroom and primidone, duloxetine, or gabapentin. However, you should always consult your doctor before taking any supplements or herbal products so they provide guidance for your specific medical situation.

Detailed Answer

Lion’s Mane mushroom is a type of edible fungus that has become a very popular dietary supplement and is purported to have various health benefits, such as enhancing cognitive function, nerve regeneration, immune system support, and antioxidant activity.

Studies show that Lion's Mane contains many bioactive compounds, such as polysaccharides, erinacines, hericenones, and lectins, that may contribute to its effects.

As with many dietary supplements, comprehensive drug interaction studies are lacking.

There is some evidence that Lion's Mane has mild antidiabetic and anticoagulant effects, so there is a theoretical interaction between it and those types of drugs.

However, there is no known interaction between it and the drugs you mentioned in your question:

• Mysoline (primidone)
• Cymbalta (duloxetine)
• Neurontin (gabapentin)

Lion's Mane is not known to alter any of the enzymes in our body that are responsible for metabolizing drugs (e.g., CYP liver metabolizing enzymes) and there have been no specific drug interactions documented with it.

As always though, I highly recommend speaking to your doctor before adding on Lion's Mane to your prescription drug regimen so you can be appropriately monitored.

Final Words

Thanks so much for reaching out! I hope you found this helpful.