Does Ashwagandha Interact With Progesterone?

In our latest question and answer, the pharmacist discusses the combined use of ashwagandha and a progestin-only pill.

Question

Does ashwagandha interact with the progesterone only pill?

Asked by Tori On Apr 08, 2024

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Apr 08, 2024
Last updated May 15, 2024

Answer

Thank you for your question!

When you mention the progesterone-only pill, I assume you're referring to oral contraceptives containing only a 'progestin,' which is a synthetic form of progesterone that mimics its effects, such as suppressing ovulation.

There are several different progestins on the market, with the most common being norethindrone. Norethindrone is the active ingredient in various branded products, including Errin, Camilla, Ortho Micronor, and others.

Our 'drug-herbal interaction checker' does not indicate any clinically significant interactions between ashwagandha and norethindrone. Similarly, there is no known interaction for ashwagandha and progesterone.

It's worth noting that several studies suggest ashwagandha supplementation might impact some hormone levels, such as FSH, LH, estradiol, and testosterone.

For example, a study in women noted a reduction in serum FSH (Follicle-stimulating Hormone) and LH (Luteinizing Hormone) after ashwagandha supplementation.

While ashwagandha might impact the levels of certain hormones, there is no evidence to suggest that it interferes with the mechanism of action of progestin-only contraceptives. Nevertheless, as with any supplement or medication, it's always a good idea to consult with a healthcare provider before starting a new regimen, especially if you have specific health concerns or are taking other medications.

Final Words

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References

  • Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males, PubMed
  • Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study, PubMed

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