Medication interaction hub

What Supplements Interact with Progesterone (prescription drug)?

Progesterone (prescription drug) brand names: Prometrium, Endometrin, Utrogestan. Every interaction below applies to the brands too.

148 Interactions 3 Major 104 Moderate 41 Minor
Curated & coded by · Clinical Pharmacist · Updated September 19, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Progesterone (prescription drug)? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Progesterone (prescription drug) against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Prescription progesterone (Prometrium, Endometrin) supports pregnancy, regulates cycles, and protects the uterine lining during estrogen therapy, and because a steady hormone level is the whole point of taking it, its 148 documented supplement interactions warrant genuine vigilance. Most of them act on CYP3A4, the liver enzyme that clears progesterone, so they can push the hormone's level up or down. Three carry a major rating: grapefruit, St. John's wort, and activated charcoal, and those deserve your attention before all the rest.

Grapefruit blocks that enzyme and can raise progesterone levels, St. John's wort speeds it up so less hormone stays in the blood, and charcoal can soak up an oral dose before it ever absorbs. The 104 moderate and 41 minor entries are mostly gentler versions of the same enzyme effects, plus a smaller cluster that slows absorption of anything swallowed; keeping those well separated from your dose removes much of that particular risk.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 104 Minor 41 No known interaction 1,304

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Progesterone (prescription drug): Top Interactions at a Glance

The Progesterone (prescription drug) supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 148 interacting ingredients — plus 1,304 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Progesterone (prescription drug) Combinations Today

The Progesterone (prescription drug) + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Ashwagandha + Progesterone (prescription drug)i

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Probable Schisandra + Progesterone (prescription drug)i

Theoretically, schisandra might increase the levels and clinical effects of CYP2C19 substrates.

Read the full interaction Moderate Likelihood Possible Cannabis + Progesterone (prescription drug)i

Cannabis may increase levels of drugs metabolized by CYP2C19.

Read the full interaction Minor Likelihood Unlikely Eleuthero + Progesterone (prescription drug)i

Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.

Read the full interaction Minor Likelihood Unlikely Green Tea + Progesterone (prescription drug)i

Green tea is unlikely to produce clinically significant changes in the levels and clinical effects of CYP3A4 substrates.

Read the full interaction Minor Likelihood Possible Vitamin D + Progesterone (prescription drug)i

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Progesterone (prescription drug)

All 1,452 ingredients in our database, ranked by severity — 148 with a Progesterone (prescription drug) interaction on file and 1,304 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Progesterone (prescription drug)?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Ashwagandha with Progesterone (prescription drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.

Full Ashwagandha + Progesterone (prescription drug) answer

Can you take Schisandra with Progesterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, schisandra might increase the levels and clinical effects of CYP2C19 substrates.

Full Schisandra + Progesterone (prescription drug) answer

Can you take Cannabis with Progesterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Cannabis may increase levels of drugs metabolized by CYP2C19.

Full Cannabis + Progesterone (prescription drug) answer

Can you take Eleuthero with Progesterone (prescription drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.

Full Eleuthero + Progesterone (prescription drug) answer

Can you take Green Tea with Progesterone (prescription drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Green tea is unlikely to produce clinically significant changes in the levels and clinical effects of CYP3A4 substrates.

Full Green Tea + Progesterone (prescription drug) answer

Can you take German Chamomile with Progesterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.

Full German Chamomile + Progesterone (prescription drug) answer

Can you take Ginger with Progesterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ginger might increase or decrease the levels of CYP3A4 substrates.

Full Ginger + Progesterone (prescription drug) answer

Can you take Goji with Progesterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goji berry might inhibit CYP2C19 and reduce metabolism of CYP2C19 substrates.

Full Goji + Progesterone (prescription drug) answer

Can you take Goldenseal with Progesterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Goldenseal might increase serum levels of drugs metabolized by CYP3A4.

Full Goldenseal + Progesterone (prescription drug) answer

Can you take Goldthread with Progesterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme.

Full Goldthread + Progesterone (prescription drug) answer

Can you take Grape with Progesterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.

Full Grape + Progesterone (prescription drug) answer

Can you take Guar Gum with Progesterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Progesterone (prescription drug) answer

Can you take Gum Arabic with Progesterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Progesterone (prescription drug) answer

Can you take Higenamine with Progesterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, higenamine might increase the levels and clinical effects drugs metabolized by CYP3A4.

Full Higenamine + Progesterone (prescription drug) answer

Can you take Horny Goat Weed with Progesterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.

Full Horny Goat Weed + Progesterone (prescription drug) answer

Can you take Hu Zhang with Progesterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hu zhang might increase levels of drugs metabolized by CYP2C19.

Full Hu Zhang + Progesterone (prescription drug) answer

Can you take Indian Long Pepper with Progesterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Indian long pepper might increase the effects and adverse effects of CYP3A4 substrates.

Full Indian Long Pepper + Progesterone (prescription drug) answer

Can you take Kava with Progesterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, kava might increase levels of CYP2C19 substrates.

Full Kava + Progesterone (prescription drug) answer

Can you take Kratom with Progesterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Kratom might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Kratom + Progesterone (prescription drug) answer

Can you take Lemongrass with Progesterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lemongrass might decrease the metabolism of CYP3A4 substrates.

Full Lemongrass + Progesterone (prescription drug) answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Progesterone (prescription drug) is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Progesterone (prescription drug), and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Progesterone (prescription drug) sits in 6 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Progesterone (prescription drug) through this category.

Cytochrome P450 2C19 (Cyp2C19) Substrates 33 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

33 of the supplement ingredients on this page reach Progesterone (prescription drug) through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Progesterone (prescription drug) through this category.

Topical Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Progesterone (prescription drug) through this category.

Progesterone 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Progesterone (prescription drug) through this category.

Progestin 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Progesterone (prescription drug) through this category.

About Progesterone (prescription drug)

Progesterone vaginal is a hormone used to support embryo implantation and maintain pregnancy during assisted reproductive technology (ART) programs, and to treat secondary amenorrhea (absent menstrual periods).

Generic name: Progesterone (prescription drug)  ·  Brand names: Prometrium, Endometrin, Utrogestan.

See the full Progesterone Vaginal drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Progesterone (prescription drug)

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Progesterone (prescription drug).

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Pharmacist Counseling Corner

Progesterone (prescription drug) & Supplements: Common Questions

What supplements interact with Progesterone (prescription drug)?
More than you might expect — 148 in total, though they are far from equal: 3 are rated major, 104 moderate, and 41 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Activated Charcoal, St. John's Wort.
Which Progesterone (prescription drug) supplement interactions are the most serious?
Focus on the major group: Grapefruit, Activated Charcoal and St. John's Wort. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Progesterone (prescription drug)?
Usually yes — most people on Progesterone (prescription drug) can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Prometrium have the same supplement interactions as Progesterone (prescription drug)?
Yes — Prometrium, Endometrin, Utrogestan all contain Progesterone (prescription drug), so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Progesterone (prescription drug) and my other medications?
This page covers Progesterone (prescription drug) against supplements and herbal ingredients. Checking Progesterone (prescription drug) against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Progesterone Vaginal drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 19, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.