Medication interaction hub

What Supplements Interact with Conjugated Estrogens?

Conjugated Estrogens brand names: Premarin, Cenestin, Enjuvia, Premarin Vaginal Cream. Every interaction below applies to the brands too.

207 Interactions 4 Major 172 Moderate 31 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Conjugated Estrogens? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Conjugated Estrogens against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Conjugated estrogens (Premarin, Cenestin) are hormone replacement, most often for menopause symptoms, and the 207 supplements here warrant real care before adding any of them. Most of the risk runs through drug processing: 121 entries involve the CYP3A4 enzyme that clears estrogen, which is how St. John's wort can drain the hormone's effect and grapefruit can push levels up. Another 60 are plant estrogens that can stack onto or compete with the drug itself.

Four of the 207 rate major, with 172 moderate and 31 minor, and those four deserve your attention first. About 20 entries interact through thyroid hormone (tiratricol is one of the majors), and charcoal products and bulky fibers like glucomannan can keep the tablet from absorbing, so take them well apart from your dose. Estrogen also slows caffeine breakdown, so coffee, tea, and cola nut appear here and your usual cup may feel stronger.

— , Clinical Pharmacist · July 18, 2026

Major 4 Moderate 172 Minor 31 No known interaction 1,245

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Conjugated Estrogens: Top Interactions at a Glance

The Conjugated Estrogens supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 207 interacting ingredients — plus 1,245 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Conjugated Estrogens Combinations Today

The Conjugated Estrogens + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Vitamin C + Conjugated Estrogensi

Vitamin C might increase blood levels of estrogens.

Read the full interaction Moderate Likelihood Possible Hemp + Conjugated Estrogensi

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.

Read the full interaction Moderate Likelihood Possible Dhea + Conjugated Estrogensi

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Probable Red Clover + Conjugated Estrogensi

Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.

Read the full interaction Moderate Likelihood Probable L-carnitine + Conjugated Estrogensi

Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.

Read the full interaction Moderate Likelihood Possible Bacopa + Conjugated Estrogensi

Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Conjugated Estrogens

All 1,452 ingredients in our database, ranked by severity — 207 with a Conjugated Estrogens interaction on file and 1,245 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Conjugated Estrogens?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Vitamin C with Conjugated Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Vitamin C might increase blood levels of estrogens.

Full Vitamin C + Conjugated Estrogens answer

Can you take Hemp with Conjugated Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.

Full Hemp + Conjugated Estrogens answer

Can you take Dhea with Conjugated Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Full Dhea + Conjugated Estrogens answer

Can you take Red Clover with Conjugated Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.

Full Red Clover + Conjugated Estrogens answer

Can you take L-carnitine with Conjugated Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.

Full L-carnitine + Conjugated Estrogens answer

Can you take Lime with Conjugated Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.

Full Lime + Conjugated Estrogens answer

Can you take Methoxylated Flavones with Conjugated Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that methoxylated flavones might inhibit cytochrome P450 3A4 (CYP3A4).

Full Methoxylated Flavones + Conjugated Estrogens answer

Can you take Milk Thistle with Conjugated Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, milk thistle might affect the clearance of drugs that undergo glucuronidation.

Full Milk Thistle + Conjugated Estrogens answer

Can you take Moringa with Conjugated Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.

Full Moringa + Conjugated Estrogens answer

Can you take Neem with Conjugated Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem leaf extract might increase the levels and clinical effects of CYP3A4 substrates.

Full Neem + Conjugated Estrogens answer

Can you take Oregon Grape with Conjugated Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP3A4.

Full Oregon Grape + Conjugated Estrogens answer

Can you take Padang Cassia with Conjugated Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that a methanol extract of Padang cassia inhibits cytochrome P450 3A4 (CYP3A4) activity.

Full Padang Cassia + Conjugated Estrogens answer

Can you take Panax Ginseng with Conjugated Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of Panax ginseng might interfere with hormone replacement therapy.

Full Panax Ginseng + Conjugated Estrogens answer

Can you take Peony with Conjugated Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of peony might interfere with hormone replacement therapy and/or increase the risk for estro...

Full Peony + Conjugated Estrogens answer

Can you take Peppermint with Conjugated Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Full Peppermint + Conjugated Estrogens answer

Can you take Phellodendron with Conjugated Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.

Full Phellodendron + Conjugated Estrogens answer

Can you take Pleurisy Root with Conjugated Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, excessive amounts of pleurisy root might interfere with hormone drug therapy.

Full Pleurisy Root + Conjugated Estrogens answer

Can you take Pregnenolone with Conjugated Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking pregnenolone might enhance the effects of estrogens.

Full Pregnenolone + Conjugated Estrogens answer

Can you take Progesterone with Conjugated Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using estrogen along with progesterone supplements or non-prescription bioidentical progesterone products might alter the eff...

Full Progesterone + Conjugated Estrogens answer

Can you take Propionyl-l-carnitine with Conjugated Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, acetyl-L-carnitine might decrease the effectiveness of thyroid hormone replacement.

Full Propionyl-l-carnitine + Conjugated Estrogens answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Conjugated Estrogens is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Conjugated Estrogens, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Conjugated Estrogens sits in 8 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Conjugated Estrogens through this category.

Estrogens 60 ingredients

Hormone-related medications. Supplements with hormone-like activity can add to or interfere with them.

60 of the supplement ingredients on this page reach Conjugated Estrogens through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Conjugated Estrogens through this category.

Thyroid Hormone 21 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

21 of the supplement ingredients on this page reach Conjugated Estrogens through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Conjugated Estrogens through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Conjugated Estrogens through this category.

Ethinyl Estradiol 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Conjugated Estrogens through this category.

Topical Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Conjugated Estrogens through this category.

Related: does Conjugated Estrogens deplete any nutrients?

Conjugated Estrogens has 20 reported nutrient associations in the research literature — see the Conjugated Estrogens nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Conjugated Estrogens

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Conjugated Estrogens.

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Pharmacist Counseling Corner

Conjugated Estrogens & Supplements: Common Questions

What supplements interact with Conjugated Estrogens?
More than you might expect — 207 in total, though they are far from equal: 4 are rated major, 172 moderate, and 31 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Activated Charcoal, St. John's Wort.
Which Conjugated Estrogens supplement interactions are the most serious?
Focus on the major group: Grapefruit, Activated Charcoal, St. John's Wort and Tiratricol. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Conjugated Estrogens?
Usually yes — most people on Conjugated Estrogens can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Premarin have the same supplement interactions as Conjugated Estrogens?
Yes — Premarin, Cenestin, Enjuvia, Premarin Vaginal Cream all contain Conjugated Estrogens, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Conjugated Estrogens deplete any vitamins or nutrients?
It might — Conjugated Estrogens has 20 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Conjugated Estrogens nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Conjugated Estrogens and my other medications?
This page covers Conjugated Estrogens against supplements and herbal ingredients. Checking Conjugated Estrogens against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.