Medication interaction hub

What Supplements Interact with Ambrisentan?

Ambrisentan brand names: Letairis, Volibris. Every interaction below applies to the brands too.

256 Interactions 9 Major 210 Moderate 37 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Ambrisentan? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Ambrisentan against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

256 supplements and herbal ingredients have interactions with Ambrisentan on file in the HelloPharmacist interaction database — 9 rated major, 210 moderate, and 37 minor. The most serious involve American Hellebore, Grapefruit, Siberian Cocklebur, Tyramine and Activated Charcoal.

Our assessment: with 9 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Ambrisentan.

Major 9 Moderate 210 Minor 37 No known interaction 1,196

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Ambrisentan: Top Interactions at a Glance

The Ambrisentan supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 256 interacting ingredients — plus 1,196 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Ambrisentan Combinations Today

The Ambrisentan + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Fish Oil + Ambrisentani

Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Probable Sodium + Ambrisentani

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.

Read the full interaction Minor Likelihood Possible Coenzyme Q10 + Ambrisentani

Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.

Read the full interaction Moderate Likelihood Probable Apple + Ambrisentani

Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.

Read the full interaction Moderate Likelihood Possible Vitamin B6 + Ambrisentani

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.

Read the full interaction Moderate Likelihood Possible Ash + Ambrisentani

Theoretically, concomitant use of ash seed with antihypertensive drugs might have additive blood pressure lowering effects.

Read the full interaction
The complete list

Every Supplement Checked Against Ambrisentan

All 1,452 ingredients in our database, ranked by severity — 256 with a Ambrisentan interaction on file and 1,196 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Ambrisentan?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Fish Oil with Ambrisentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.

Full Fish Oil + Ambrisentan answer

Can you take Sodium with Ambrisentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.

Full Sodium + Ambrisentan answer

Can you take Coenzyme Q10 with Ambrisentan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.

Full Coenzyme Q10 + Ambrisentan answer

Can you take Apple with Ambrisentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.

Full Apple + Ambrisentan answer

Can you take Vitamin B6 with Ambrisentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.

Full Vitamin B6 + Ambrisentan answer

Can you take Strawberry with Ambrisentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that strawberry extract can inhibit p-glycoprotein efflux.

Full Strawberry + Ambrisentan answer

Can you take Sulforaphane with Ambrisentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sulforaphane might increase the levels and effects of CYP3A4 substrates.

Full Sulforaphane + Ambrisentan answer

Can you take Sweet Annie with Ambrisentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Sweet Annie + Ambrisentan answer

Can you take Sweet Clover with Ambrisentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sweet clover with hepatoxic drugs might increase the risk of hepatotoxicity.

Full Sweet Clover + Ambrisentan answer

Can you take Sweet Orange with Ambrisentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.

Full Sweet Orange + Ambrisentan answer

Can you take Syrian Rue with Ambrisentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of Syrian rue might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Syrian Rue + Ambrisentan answer

Can you take Terminalia with Ambrisentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.

Full Terminalia + Ambrisentan answer

Can you take Testolone with Ambrisentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Testolone + Ambrisentan answer

Can you take Theanine with Ambrisentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.

Full Theanine + Ambrisentan answer

Can you take Thunder God Vine with Ambrisentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, thunder god vine might increase the levels and clinical effects of CYP3A4 substrates.

Full Thunder God Vine + Ambrisentan answer

Can you take Tragacanth with Ambrisentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Ambrisentan answer

Can you take Tribulus with Ambrisentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Full Tribulus + Ambrisentan answer

Can you take Turmeric with Ambrisentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Turmeric + Ambrisentan answer

Can you take Uva Ursi with Ambrisentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.

Full Uva Ursi + Ambrisentan answer

Can you take Vitamin A with Ambrisentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disea...

Full Vitamin A + Ambrisentan answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Ambrisentan is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Ambrisentan, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Ambrisentan sits in 6 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Ambrisentan through this category.

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Ambrisentan through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Ambrisentan through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Ambrisentan through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Ambrisentan through this category.

Ambrisentan (Letairis) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Ambrisentan through this category.

About Ambrisentan

Ambrisentan is an endothelin receptor antagonist used to treat pulmonary arterial hypertension (PAH) in adults, improving exercise ability and slowing disease progression.

Generic name: Ambrisentan  ·  Brand names: Letairis, Volibris.

See the full Ambrisentan drug information

Related: does Ambrisentan deplete any nutrients?

Ambrisentan has 2 reported nutrient associations in the research literature — see the Ambrisentan nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Ambrisentan

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Ambrisentan.

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Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Pharmacist Counseling Corner

Ambrisentan & Supplements: Common Questions

What supplements interact with Ambrisentan?
Our database currently documents 256 ingredients with a known Ambrisentan interaction (9 major, 210 moderate, 37 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 256. The highest-ranked right now: American Hellebore, Grapefruit, Siberian Cocklebur.
Which Ambrisentan supplement interactions are the most serious?
The 9 major-rated combinations — led by American Hellebore, Grapefruit, Siberian Cocklebur, Tyramine and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Ambrisentan?
Plenty of supplements coexist fine with Ambrisentan; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Letairis have the same supplement interactions as Ambrisentan?
Yes — Letairis, Volibris all contain Ambrisentan, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Ambrisentan deplete any vitamins or nutrients?
It might — Ambrisentan has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Ambrisentan nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Ambrisentan and my other medications?
This page covers Ambrisentan against supplements and herbal ingredients. Checking Ambrisentan against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Ambrisentan drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.