Medication interaction hub

What Supplements Interact with Bosentan?

Bosentan brand name: Tracleer. Every interaction below applies to the brands too.

266 Interactions 11 Major 216 Moderate 39 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Bosentan? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Bosentan against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

266 supplements and herbal ingredients have interactions with Bosentan on file in the HelloPharmacist interaction database — 11 rated major, 216 moderate, and 39 minor. The most serious involve American Hellebore, Apple, Grapefruit, Siberian Cocklebur and Sweet Orange.

Our assessment: with 11 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Bosentan.

Major 11 Moderate 216 Minor 39 No known interaction 1,186

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Bosentan: Top Interactions at a Glance

The Bosentan supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 266 interacting ingredients — plus 1,186 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Bosentan Combinations Today

The Bosentan + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Major Likelihood Likely Apple + Bosentani

Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.

Read the full interaction Moderate Likelihood Possible Grape + Bosentani

It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.

Read the full interaction Moderate Likelihood Possible Cranberry + Bosentani

Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Black Cohosh + Bosentani

Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.

Read the full interaction Major Likelihood Likely Sweet Orange + Bosentani

Consuming sweet orange juice can decrease oral absorption of OATP substrates.

Read the full interaction Minor Likelihood Possible Evening Primrose + Bosentani

Theoretically, evening primrose may increase the levels and clinical effects of CYP2C9 substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Bosentan

All 1,452 ingredients in our database, ranked by severity — 266 with a Bosentan interaction on file and 1,186 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Bosentan?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Apple with Bosentan?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.

Full Apple + Bosentan answer

Can you take Grape with Bosentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.

Full Grape + Bosentan answer

Can you take Cranberry with Bosentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.

Full Cranberry + Bosentan answer

Can you take Black Cohosh with Bosentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.

Full Black Cohosh + Bosentan answer

Can you take Sweet Orange with Bosentan?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Consuming sweet orange juice can decrease oral absorption of OATP substrates.

Full Sweet Orange + Bosentan answer

Can you take Asafoetida with Bosentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that asafoetida has hypotensive effects.

Full Asafoetida + Bosentan answer

Can you take Ash with Bosentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of ash seed with antihypertensive drugs might have additive blood pressure lowering effects.

Full Ash + Bosentan answer

Can you take Ashwagandha with Bosentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.

Full Ashwagandha + Bosentan answer

Can you take Astaxanthin with Bosentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.

Full Astaxanthin + Bosentan answer

Can you take Ayahuasca with Bosentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ayahuasca might increase plasma concentrations of CYP3A4 substrates.

Full Ayahuasca + Bosentan answer

Can you take Bacopa with Bosentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bacopa might increase the levels and adverse effects of CYP2C9 substrates.

Full Bacopa + Bosentan answer

Can you take Baikal Skullcap with Bosentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Baikal skullcap with antihypertensive drugs might have additive effects and increase the risk of hypotensi...

Full Baikal Skullcap + Bosentan answer

Can you take Basil with Bosentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, basil might increase the risk of hypotension when taken with antihypertensive drugs.

Full Basil + Bosentan answer

Can you take Beet with Bosentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, beet might increase the levels of CYP3A4 substrates.

Full Beet + Bosentan answer

Can you take Berberine with Bosentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might have additive effects with antihypertensive drugs.

Full Berberine + Bosentan answer

Can you take Beta-glucans with Bosentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.

Full Beta-glucans + Bosentan answer

Can you take Beta-methylphenethylamine (bmpea) with Bosentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, BMPEA might increase the levels and clinical effects of CYP3A4 substrates.

Full Beta-methylphenethylamine (bmpea) + Bosentan answer

Can you take Betony with Bosentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, betony might have additive effects with blood pressure lowering drugs due to hypotensive activity of the glycosides found in...

Full Betony + Bosentan answer

Can you take Bishop's Weed with Bosentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bergapten, a constituent of bishop's weed, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Bishop's Weed + Bosentan answer

Can you take Bitter Orange with Bosentan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bitter orange might increase levels of drugs metabolized by CYP3A4.

Full Bitter Orange + Bosentan answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Bosentan is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Bosentan, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Bosentan sits in 6 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Bosentan through this category.

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Bosentan through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Bosentan through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Bosentan through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Bosentan through this category.

Organic Anion-Transporting Polypeptide Substrates (Oatp) 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Bosentan through this category.

About Bosentan

Bosentan is an endothelin receptor antagonist used to treat pulmonary arterial hypertension (PAH) in adults and children aged 3 and older.

Generic name: Bosentan  ·  Brand name: Tracleer.

See the full Bosentan drug information

Related: does Bosentan deplete any nutrients?

Bosentan has 1 reported nutrient association in the research literature — see the Bosentan nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Bosentan

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Bosentan.

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Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Pharmacist Counseling Corner

Bosentan & Supplements: Common Questions

What supplements interact with Bosentan?
More than you might expect — 266 in total, though they are far from equal: 11 are rated major, 216 moderate, and 39 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: American Hellebore, Apple, Grapefruit.
Which Bosentan supplement interactions are the most serious?
The 11 major-rated combinations — led by American Hellebore, Apple, Grapefruit, Siberian Cocklebur and Sweet Orange — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Bosentan?
Usually yes — most people on Bosentan can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Tracleer have the same supplement interactions as Bosentan?
Yes — Tracleer all contain Bosentan, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Bosentan deplete any vitamins or nutrients?
It might — Bosentan has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Bosentan nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Bosentan and my other medications?
This page covers Bosentan against supplements and herbal ingredients. Checking Bosentan against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Bosentan drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.