Medication interaction hub

What Supplements Interact with Glyburide?

Glyburide brand names: Diabeta, Micronase, Glynase, Glycron, Micronized, and others. Every interaction below applies to the brands too.

331 Interactions 7 Major 279 Moderate 45 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Glyburide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Glyburide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

331 supplements and herbal ingredients have interactions with Glyburide on file in the HelloPharmacist interaction database — 7 rated major, 279 moderate, and 45 minor. The most serious involve Apple, Grapefruit, Siberian Cocklebur, Sweet Orange and Activated Charcoal.

Our assessment: with 7 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Glyburide.

Major 7 Moderate 279 Minor 45 No known interaction 1,121

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Glyburide: Top Interactions at a Glance

The Glyburide supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 331 interacting ingredients — plus 1,121 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Glyburide Combinations Today

The Glyburide + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Major Likelihood Likely Apple + Glyburidei

Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.

Read the full interaction Moderate Likelihood Possible Capsicum + Glyburidei

Theoretically, taking capsicum with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Black Cohosh + Glyburidei

Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.

Read the full interaction Moderate Likelihood Possible Kava + Glyburidei

Theoretically, using kava with hepatotoxic drugs might increase the risk of liver damage.

Read the full interaction Minor Likelihood Possible Karaya Gum + Glyburidei

Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption of drugs.

Read the full interaction Minor Likelihood Possible Algin + Glyburidei

Theoretically, algin can alter the absorption of oral drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Glyburide

All 1,452 ingredients in our database, ranked by severity — 331 with a Glyburide interaction on file and 1,121 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Glyburide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Apple with Glyburide?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.

Full Apple + Glyburide answer

Can you take Capsicum with Glyburide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking capsicum with antidiabetes drugs might increase the risk of hypoglycemia.

Full Capsicum + Glyburide answer

Can you take Black Cohosh with Glyburide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.

Full Black Cohosh + Glyburide answer

Can you take Kava with Glyburide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using kava with hepatotoxic drugs might increase the risk of liver damage.

Full Kava + Glyburide answer

Can you take Karaya Gum with Glyburide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Glyburide answer

Can you take Aloe with Glyburide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Aloe + Glyburide answer

Can you take Ambrette with Glyburide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of ambrette with antidiabetes drugs might increase the risk of hypoglycemia.

Full Ambrette + Glyburide answer

Can you take Angelica Archangelica with Glyburide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Full Angelica Archangelica + Glyburide answer

Can you take Anise with Glyburide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, anise seed might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Anise + Glyburide answer

Can you take Annatto with Glyburide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal studies suggest that certain annatto extracts may have hypoglycemic or hyperglycemic effects.

Full Annatto + Glyburide answer

Can you take Arabinoxylan with Glyburide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from human research suggests that an arabinoxylan-rich fiber can reduce postprandial glucose levels.

Full Arabinoxylan + Glyburide answer

Can you take Arrach with Glyburide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of arrach can increase risk of adverse effects, as unspecified Chenopodium species are associated with photos...

Full Arrach + Glyburide answer

Can you take Artemisia Herba-alba with Glyburide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with antidiabetes drugs might increase the risk of hypoglycemia.

Full Artemisia Herba-alba + Glyburide answer

Can you take Artichoke with Glyburide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Artichoke + Glyburide answer

Can you take Ash with Glyburide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with antidiabetes drugs might affect glucose control and increase the risk of hypoglycemia.

Full Ash + Glyburide answer

Can you take Ashwagandha with Glyburide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.

Full Ashwagandha + Glyburide answer

Can you take Avocado Sugar Extract with Glyburide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, avocado sugar extract might increase blood glucose levels, and decrease the effects of antidiabetic agents.

Full Avocado Sugar Extract + Glyburide answer

Can you take Ba Ji Tian with Glyburide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research shows that taking ba ji tian extracts might increase or decrease blood glucose levels.

Full Ba Ji Tian + Glyburide answer

Can you take Bacopa with Glyburide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bacopa might increase the levels and adverse effects of CYP2C9 substrates.

Full Bacopa + Glyburide answer

Can you take Bael with Glyburide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that extracts of bael seed and leaf can reduce blood glucose levels.

Full Bael + Glyburide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Glyburide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Glyburide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Glyburide sits in 8 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Glyburide through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Glyburide through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Glyburide through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Glyburide through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Glyburide through this category.

Organic Anion-Transporting Polypeptide Substrates (Oatp) 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Glyburide through this category.

Glyburide (Diabeta, Others) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Glyburide through this category.

Sulfonylureas 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Glyburide through this category.

About Glyburide

Glyburide is a sulfonylurea medication that lowers blood sugar in people with type 2 diabetes.

Generic name: Glyburide  ·  Brand names: Diabeta, Micronase, Glynase, Glycron, Micronized, Glynase PresTab, Albert Glyburide.

See the full Glyburide drug information

Related: does Glyburide deplete any nutrients?

Glyburide has 7 reported nutrient associations in the research literature — see the Glyburide nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Glyburide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Glyburide.

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Pharmacist Counseling Corner

Glyburide & Supplements: Common Questions

What supplements interact with Glyburide?
In our interaction database, 331 supplement and herbal ingredients have an interaction with Glyburide on file — 7 rated major, 279 moderate, and 45 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Apple, Grapefruit, Siberian Cocklebur.
Which Glyburide supplement interactions are the most serious?
Focus on the major group: Apple, Grapefruit, Siberian Cocklebur, Sweet Orange and Activated Charcoal, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Glyburide?
That depends entirely on which supplement. The honest answer for Glyburide is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Diabeta have the same supplement interactions as Glyburide?
Yes — Diabeta, Micronase, Glynase, Glycron, Micronized and other brands all contain Glyburide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Glyburide deplete any vitamins or nutrients?
It might — Glyburide has 7 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Glyburide nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Glyburide and my other medications?
This page covers Glyburide against supplements and herbal ingredients. Checking Glyburide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Glyburide drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.