Medication interaction hub

What Supplements Interact with Glimepiride?

Glimepiride brand name: Amaryl. Every interaction below applies to the brands too.

306 Interactions 2 Major 256 Moderate 48 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Glimepiride? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Glimepiride against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Glimepiride (Amaryl) is a sulfonylurea, a diabetes pill that prompts the pancreas to release insulin, so anything that further lowers blood sugar can tip you into hypoglycemia, and that describes most of this list. Of the 306 supplement and herbal ingredients on file, 239 can move blood sugar on their own. This is a list to respect, starting with the two rated major: Siberian cocklebur, which has caused severe hypoglycemia in humans, and activated charcoal, which soaks up oral drugs and can leave glucose running high instead.

The remaining 256 moderate and 48 minor entries mostly nudge sugar downward, fenugreek among the everyday examples, though alcohol can swing it either way. Sixty-four share the liver enzyme (CYP2C9) that clears glimepiride and could change its blood level, and 20 add to sun sensitivity. Check your glucose more often whenever you start one of these, and know the signs of a low: shakiness, sweating, sudden confusion.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 256 Minor 48 No known interaction 1,146

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Glimepiride: Top Interactions at a Glance

The Glimepiride supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 306 interacting ingredients — plus 1,146 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Glimepiride Combinations Today

The Glimepiride + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Turkey Tail Mushroom + Glimepiridei

Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible L-cysteine + Glimepiridei

Theoretically, taking L-cysteine supplements with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible White Mulberry + Glimepiridei

Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction Minor Likelihood Unlikely Cola Nut + Glimepiridei

Theoretically, taking cola nut with antidiabetes drugs might interfere with blood glucose control.

Read the full interaction Moderate Likelihood Possible Chicory + Glimepiridei

Theoretically, chicory might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction Minor Likelihood Unlikely Glucosamine + Glimepiridei

Despite initial concerns, it is unlikely that glucosamine will interfere with the effects of antidiabetes drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Glimepiride

All 1,452 ingredients in our database, ranked by severity — 306 with a Glimepiride interaction on file and 1,146 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Glimepiride?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Turkey Tail Mushroom with Glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.

Full Turkey Tail Mushroom + Glimepiride answer

Can you take L-cysteine with Glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking L-cysteine supplements with antidiabetes drugs might increase the risk of hypoglycemia.

Full L-cysteine + Glimepiride answer

Can you take White Mulberry with Glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full White Mulberry + Glimepiride answer

Can you take Cola Nut with Glimepiride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking cola nut with antidiabetes drugs might interfere with blood glucose control.

Full Cola Nut + Glimepiride answer

Can you take Chicory with Glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chicory might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Chicory + Glimepiride answer

Can you take Angelica Archangelica with Glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Full Angelica Archangelica + Glimepiride answer

Can you take Anise with Glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, anise seed might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Anise + Glimepiride answer

Can you take Annatto with Glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal studies suggest that certain annatto extracts may have hypoglycemic or hyperglycemic effects.

Full Annatto + Glimepiride answer

Can you take Apple with Glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, consuming apple juice with antidiabetes drugs might interfere with blood glucose control.

Full Apple + Glimepiride answer

Can you take Arabinoxylan with Glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from human research suggests that an arabinoxylan-rich fiber can reduce postprandial glucose levels.

Full Arabinoxylan + Glimepiride answer

Can you take Arrach with Glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of arrach can increase risk of adverse effects, as unspecified Chenopodium species are associated with photos...

Full Arrach + Glimepiride answer

Can you take Artemisia Herba-alba with Glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with antidiabetes drugs might increase the risk of hypoglycemia.

Full Artemisia Herba-alba + Glimepiride answer

Can you take Artichoke with Glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Artichoke + Glimepiride answer

Can you take Ash with Glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with antidiabetes drugs might affect glucose control and increase the risk of hypoglycemia.

Full Ash + Glimepiride answer

Can you take Ashwagandha with Glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.

Full Ashwagandha + Glimepiride answer

Can you take Avocado Sugar Extract with Glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, avocado sugar extract might increase blood glucose levels, and decrease the effects of antidiabetic agents.

Full Avocado Sugar Extract + Glimepiride answer

Can you take Ba Ji Tian with Glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research shows that taking ba ji tian extracts might increase or decrease blood glucose levels.

Full Ba Ji Tian + Glimepiride answer

Can you take Bacopa with Glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bacopa might increase the levels and adverse effects of CYP2C9 substrates.

Full Bacopa + Glimepiride answer

Can you take Bael with Glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that extracts of bael seed and leaf can reduce blood glucose levels.

Full Bael + Glimepiride answer

Can you take Baikal Skullcap with Glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Baikal skullcap with antidiabetes drugs might enhance blood glucose lowering effects.

Full Baikal Skullcap + Glimepiride answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Glimepiride is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Glimepiride, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Glimepiride sits in 5 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Glimepiride through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Glimepiride through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Glimepiride through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Glimepiride through this category.

Sulfonylureas 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Glimepiride through this category.

About Glimepiride

Glimepiride is a diabetes medication that lowers blood sugar by helping the pancreas produce insulin and making the body use it better.

Generic name: Glimepiride  ·  Brand name: Amaryl.

See the full Glimepiride drug information

Related: does Glimepiride deplete any nutrients?

Glimepiride has 1 reported nutrient association in the research literature — see the Glimepiride nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Glimepiride

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Glimepiride.

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Pharmacist Counseling Corner

Glimepiride & Supplements: Common Questions

What supplements interact with Glimepiride?
Our database currently documents 306 ingredients with a known Glimepiride interaction (2 major, 256 moderate, 48 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 306. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, American Ginseng.
Which Glimepiride supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur and Activated Charcoal. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Glimepiride?
Plenty of supplements coexist fine with Glimepiride; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Amaryl have the same supplement interactions as Glimepiride?
Yes — Amaryl all contain Glimepiride, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Glimepiride deplete any vitamins or nutrients?
It might — Glimepiride has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Glimepiride nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Glimepiride and my other medications?
This page covers Glimepiride against supplements and herbal ingredients. Checking Glimepiride against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Glimepiride drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.