Drug & supplement interaction

Oolong Tea + Glimepiride

Glimepiride brand name: Amaryl.

Minor Interaction
Medically reviewed by · Updated September 2026
The bottom line Minor

Oolong Tea has a minor interaction with Glimepiride. Theoretically, taking oolong tea with antidiabetes drugs might interfere with blood glucose control.

Read the full interaction report
SeverityMinor
LikelihoodUnlikely
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Oolong Tea and Glimepiride

Here is the interaction we found between these two, with the evidence behind it.

Minor

ANTIDIABETES DRUGS

Why this applies to Glimepiride

Glimepiride falls under ANTIDIABETES DRUGS — the group Oolong Tea interacts with.

Theoretically, taking oolong tea with antidiabetes drugs might interfere with blood glucose control.
Oolong tea contains caffeine. Reports claim that caffeine might increase or decrease blood glucose levels.
Severity Minor Likelihood Unlikely Evidence B

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist: glimepiride lowers your blood sugar by nudging your pancreas to release more insulin. The caffeine in oolong tea can tug on your blood sugar a little too, and the tricky part is that reports go both ways. Sometimes caffeine bumps sugar up, sometimes down. So in theory, drinking oolong tea could make your numbers a touch less predictable while you're on glimepiride.

Honestly, this is a minor and unlikely concern, and the evidence behind it is weak. A few cups of tea probably won't throw things off. The main thing I'd watch for is whether your blood sugar readings start bouncing around. If you notice shakiness, sweating, or unusual highs and lows, mention it to your pharmacist or doctor before changing anything.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Watson JM, Jenkins EJ, Hamilton P, et al. Influence of caffeine on the frequency and perception of hypoglycemia in free-living patients with type 1 diabetes. Diabetes Care 2000;23:455-9. PubMed
  2. Bell DG, Jacobs I, Ellerington K. Effect of caffeine and ephedrine ingestion on anaerobic exercise performance. Med Sci Sports Exerc 2001;33:1399-403. PubMed
  3. Baer DJ, Novotny JA, Harris GK, Stote K, Clevidence B, Rumpler WV. Oolong tea does not improve glucose metabolism in non-diabetic adults. Eur J Clin Nutr 2011;65(1):87-93. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Oolong Tea Also Interacts With Other Medications

Oolong Tea has 8 major, 518 moderate, 125 minor known drug interactions in our database — the Glimepiride one above is one of them. If you take anything else, check it against the full list below.

Major 8 Moderate 518 Minor 125 No known interaction 2,179 (incl. Glimepiride)
Taking anything else?

Check Another of Your Medications Against Oolong Tea

Covers the 2,830 medications we’ve checked against Oolong Tea. Pick one to open its full report.

From our Q&A

Questions About Oolong Tea or Glimepiride

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Oolong Tea or Glimepiride, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Glimepiride

This page covers Oolong Tea only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Glimepiride page lists 306 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), Adrafinil (moderate) and African Wild Potato (moderate).

By severity: 2 major · 256 moderate · 48 minor.

From our pharmacist’s overview on the Glimepiride page

“Glimepiride (Amaryl) is a sulfonylurea, a diabetes pill that prompts the pancreas to release insulin, so anything that further lowers blood sugar can tip you into hypoglycemia, and that describes most of this list. Of the 306 supplement and herbal ingredients on file, 239 can move blood sugar on their own.”

Reviewed by 2 · Jul 18, 2026

Open the Glimepiride interaction page

One more smart check

Taking Oolong Tea as Part of a Dietary Supplement Product? Check It for Interactions

We hold 75 real supplement products containing Oolong Tea, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Oolong Tea. Your product may carry other ingredients that interact with Glimepiride too, on top of Oolong Tea — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Oolong Tea and Glimepiride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Oolong Tea
Steady interest

#1,109 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Glimepiride
Steady interest

#1,893 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Oolong Tea

What is Oolong Tea?

  • Weight management
  • Mental alertness and energy
  • Heart health
  • Blood sugar support
  • Antioxidant support

Oolong tea is a traditional partially oxidized tea made from the same plant as green and black tea, and it provides caffeine and plant antioxidants. As a beverage it is generally considered safe for most healthy adults in moderate amounts, but evidence for specific health benefits like weight loss or blood sugar control is limited. If you have heart, blood pressure, or caffeine-sensitivity concerns, talk with your pharmacist or doctor.

Read the full Oolong Tea monograph & all interactions
Medication

About Glimepiride

What Is Glimepiride Used For?

Brand name: Amaryl

Glimepiride tablets are used to improve blood sugar control in adults with type 2 diabetes. It is always used together with a healthy diet and regular exercise — not as a standalone treatment.

Glimepiride is not appropriate for type 1 diabetes or diabetic ketoacidosis (a serious complication where the body produces high levels of blood acids called ketones), as it would not work in those situations.

See full Glimepiride drug information
Keep checking

Other Drugs & Oolong Tea

Browse every other medication we’ve checked against Oolong Tea — both the ones with a known interaction and the ones without. Select any drug for the full detail.

8Major
518Moderate
125Minor
2,178No known interaction
8 Major 518 Moderate 125 Minor 2,178 No interaction
Major

8 interactions

Moderate

518 interactions

Showing 60 of 518 moderate interactions — see all 518 on the Oolong Tea page.

Minor

125 interactions

Showing 60 of 125 minor interactions — see all 125 on the Oolong Tea page.

No interaction 2,178 drugs checked — show the list

We also checked Oolong Tea against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,178 medications checked with no known interaction — see the full Oolong Tea list.

See the full Oolong Tea interactions page
See every supplement checked against Glimepiride, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Oolong Tea monograph › Uses, safety, and every drug interaction in one place Glimepiride supplement interactions › Every supplement checked against Glimepiride, ranked by severity Glimepiride drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Oolong Tea and Glimepiride Together: Common Questions

Can you take Oolong Tea with Glimepiride?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Oolong Tea and Glimepiride interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Glimepiride and Oolong Tea?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.