Herb & supplement monograph

Mesoglycan Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Mesoglycan interacts with medications. The heart of this page is the interaction list — every drug Mesoglycan is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Mesoglycan is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Mesoglycan Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Mesoglycan drug interaction appears low for most people, though anyone on blood-thinning treatment deserves a closer look. None of the listed interactions are rated major, and all of them rest on the same theoretical bleeding concern rather than documented harm in people.

Interactions deserving the most attention

The interactions that matter most involve anticoagulant and antiplatelet drugs, including warfarin, aspirin, clopidogrel, heparin, and related medicines, and thrombolytic drugs used to dissolve clots. In theory, adding mesoglycan could raise bleeding risk with any of these. That said, human research suggests mesoglycan helps the body break down clots without actually changing how blood coagulates, so the concern has not been confirmed in people. Because bleeding is a narrow-margin issue, this combination is still worth monitoring rather than ignoring.

What the rest of the list means

Although the list of interacting medications runs long, nearly all of those entries are individual drugs that fall into these two blood-related categories, so the list reflects one shared theoretical concern rather than many separate problems. No interaction here is rated major, and the predicted effect on clotting has not been shown to produce meaningful changes in human studies.

Check your medications against Mesoglycan

Based on HelloPharmacist’s Mesoglycan interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Mesoglycan

122 medications have a known interaction with Mesoglycan, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
AbciximabReoPro› AbrocitinibCibinqo› AcenocoumarolSintrom› Acetaminophen, AspirinGemnisyn› Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine› Acetaminophen, IbuprofenCombogesic› Acetylsalicylic AcidEntrophen› Alteplase, TpaActilyse, Activase› Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2› Aluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin› Anacaulase-bcdbNexoBrid› AnagrelideAgrylin› AnisindioneMiradon› Antithrombin IiiThrombate III› ApixabanEliquis› ArgatrobanArgatroban› AspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more› Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3› Aspirin, ButalbitalAxotal› Aspirin, Butalbital, CaffeineFiorinal› Aspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine› Aspirin, Butalbital, Caffeine, PhenacetinMarnal› Aspirin, CaffeineAnacin› Aspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine› Aspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC› Aspirin, Caffeine, Dover's PwdAcedoval, Dovacet› Aspirin, Caffeine, HydrocodoneDamason-P› Aspirin, Caffeine, Isobutylallylbarbituric Acid, PhenacetinLanorinal› Aspirin, Caffeine, OrphenadrineInvagesic, Invagesic Forte, Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte› Aspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65›
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Mesoglycan combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Mesoglycan affects

Every type of medication (drug category) Mesoglycan is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 2 drug categories Mesoglycan interacts with
Anticoagulant/antiplatelet DrugsThrombolytic Drugs
Anticoagulant/Antiplatelet Drugs

Theoretically, combined use might increase bleeding risk. However, human evidence suggests that mesoglycan has profibrinolytic activity without affecting coagulation. These agents include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.

Likelihood Possible Evidence B
Thrombolytic Drugs

Theoretically, combined use might increase bleeding risk. These drugs include alteplase (Activase), anistreplase (Eminase), reteplase (Retevase), streptokinase (Streptase), and urokinase (Abbokinase).

Likelihood Possible Evidence B
Monograph

Mesoglycan: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Mesoglycan is a blend of natural sugar-protein compounds (glycosaminoglycans, including heparan sulfate and dermatan sulfate) taken from animal tissue and used mainly for blood vessel and circulation problems. Some small studies suggest possible benefit for vein-related conditions, but the overall evidence is limited and not strong. Because it can affect blood clotting, talk to your doctor or pharmacist before using it.

Part used
Glycosaminoglycans extracted from porcine (pig) intestinal mucosa
Common forms
Tablets, capsules
People commonly use it for
  • Vein health and chronic venous insufficiency
  • Leg ulcers
  • Peripheral artery disease and leg pain
  • Reducing blood clot risk
  • Hemorrhoids

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally tolerated in studies, but it can affect blood clotting and lacks long-term safety data.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Mesoglycan is not a herb or plant. It is a natural mixture of compounds called glycosaminoglycans (GAGs), which are sugar-protein molecules that normally line the inside of blood vessels. The mesoglycan used in supplements is usually taken from the intestinal lining of pigs.

The mixture contains substances such as heparan sulfate, dermatan sulfate, and small amounts of other GAGs. These are similar to compounds found naturally in the human body that help blood flow smoothly and keep vessel walls healthy.

Mesoglycan is sold mostly in Europe as a prescription or supplement product. People most often use it for problems with veins and circulation, such as varicose veins, leg swelling, and slow-healing leg ulcers.

How it works

The glycosaminoglycans in mesoglycan are similar to natural compounds in the lining of your blood vessels. Researchers believe they may help in a few ways:

  • Mild blood-thinning effect — some of the compounds are related to heparin and may make blood less likely to clot.
  • Supporting vessel walls — they may help keep the inner lining of blood vessels healthy and reduce inflammation.
  • Improving blood flow and breaking down clots — lab studies suggest they may support the body's natural clot-dissolving system.

Much of this understanding comes from laboratory and animal research or from how similar molecules behave in the body. The exact effects in people are not fully proven.

Effectiveness

Does Mesoglycan work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 15 uses evaluated
3 Possibly effective 2 Leans ineffective 10 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Possibly Effective Cerebrovascular disease
Rating & evidence shown verbatim from Natural Medicines

Preliminary clinical research in small groups of patients with cerebrovascular disease shows that taking mesoglycan 96-100 mg daily orally for 6 months seems to reduce ischemic events, improve quality of life, and provide subjective improvement when compared with baseline. The validity of this finding is limited by the lack of a comparator group. There is also some preliminary evidence that mesoglycan might be comparable to standard antiplatelet drug therapy.

Sources Ref 6635 Ref 6637 Ref 6639
Possibly Effective Peripheral arterial disease (PAD)
Rating & evidence shown verbatim from Natural Medicines

The majority of preliminary clinical research shows that mesoglycan improves walking distance in patients with PAD, although it may not be as effective as other therapies. Alternating intravenous and oral mesoglycan seems to improve walking distance when compared with baseline in patients with intermittent claudication due to PAD. Also, injecting mesoglycan 30 mg intramuscularly for 3 weeks then taking oral mesoglycan 100 mg daily for 20 weeks appears to improve clinical response and walking distance in patients with PAD when compared with placebo. Taking mesoglycan 100 mg daily orally for a total of 120 days increases walking distance by approximately 39% when compared with baseline. However, taking oral mesoglycan 48 mg daily for 6 months is less effective at improving pain-free walking distance and total walking distance than oral defibrotide 800 mg daily in patients with intermittent claudication due to PAD.

Sources Ref 6629 Ref 31635 Ref 97779 Ref 31647
Possibly Effective Venous leg ulcers
Rating & evidence shown verbatim from Natural Medicines

Clinical research shows that administering a combination of intramuscular and oral mesoglycan as an adjunct to traditional chronic venous stasis ulcer therapy improves the rate of healing when compared with traditional therapy alone. At least 75% of patients taking mesoglycan were fully healed approximately 46 days earlier than patients taking traditional therapy alone.

Sources Ref 11479
Possibly Ineffective Stroke
Rating & evidence shown verbatim from Natural Medicines

Clinical research in patients with acute ischemic stroke shows that adding intramuscular mesoglycan for 5 days, followed by 25 days of oral mesoglycan, to intravenous dexamethasone therapy is no more effective than dexamethasone alone.

Sources Ref 6641
Possibly Ineffective Venous thromboembolism (VTE)
Rating & evidence shown verbatim from Natural Medicines

Clinical research shows that taking oral mesoglycan plus compression stockings following standard deep venous thrombosis (DVT) therapy is no better than placebo for preventing recurrent DVT and/or pulmonary embolism during a follow-up period ranging from 5 to 48 months.

Sources Ref 6640
Also studied for 10 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Atherosclerosis
Rating & evidence shown verbatim from Natural Medicines

Preliminary clinical research shows that taking oral mesoglycan 200 mg daily for 18 months might slow the progression of atherosclerosis by decreasing the rate of carotid and femoral artery intima-media thickening.

Sources Ref 6628 Ref 31649
Insufficient Reliable Evidence To Rate Chronic venous insufficiency (CVI)
Rating & evidence shown verbatim from Natural Medicines

Preliminary clinical research in adults with unilateral lower limb edema due to CVI shows that taking mesoglycan 100 mg daily for one month reduces pain and swelling by approximately 43% and 63%, respectively, when compared with placebo.

Sources Ref 97778
Insufficient Reliable Evidence To Rate Cutaneous necrotizing venulitis
Rating & evidence shown verbatim from Natural Medicines

Preliminary clinical research shows that intramuscular mesoglycan 10 mg/kg daily for 20 days might be useful for treating cutaneous necrotizing venulitis in patients with reduced fibrinolytic activity.

Sources Ref 6634
Insufficient Reliable Evidence To Rate Diabetic retinopathy
Rating & evidence shown verbatim from Natural Medicines

Preliminary clinical research in adults with diabetic retinopathy shows that taking mesoglycan 100 mg daily for 6 months reduces the occurrence of microhemorrhages, microaneurysms, and exudates, compared with no change in those taking placebo.

Sources Ref 97777
Insufficient Reliable Evidence To Rate Hypertension
Rating & evidence shown verbatim from Natural Medicines

Preliminary clinical research shows that taking mesoglycan 100 mg daily orally for a total of 120 days reduces systolic blood pressure by 5 mmHg when compared to baseline in patients with hypertension. The validity of this finding is limited by the lack of a comparator group.

Sources Ref 97779
Insufficient Reliable Evidence To Rate Hypertriglyceridemia
Rating & evidence shown verbatim from Natural Medicines

Preliminary clinical research in a small group of patients shows that taking mesoglycan 96 mg daily reduces total triglyceride and very low density lipoprotein (VLDL) levels when compared to baseline in patients with hypertriglyceridemia.The validity of this finding is limited by the lack of a comparator group.

Sources Ref 6646
Insufficient Reliable Evidence To Rate Metabolic syndrome
Rating & evidence shown verbatim from Natural Medicines

Preliminary clinical research in a small group of patients with metabolic syndrome shows that taking mesoglycan 50 mg twice daily for 90 days improves vascular function, as measured by brachial flow-mediated dilation and arterial stiffness, when compared with placebo.

Sources Ref 103265
Insufficient Reliable Evidence To Rate Postoperative pain
Rating & evidence shown verbatim from Natural Medicines

Preliminary, prospective clinical research in a small group of patients undergoing open excisional diathermy hemorrhoidectomy shows that intramuscular mesoglycan (Prisma, Mediolanum Farmaceutici) 60 mg daily for 5 days postoperatively, then 50 mg orally twice daily for 30 days, reduces pain after rectal examination, but not spontaneous pain or pain after defecation, and shortens the time to full resumption of normal daily activities, when compared with ketorolac 10 mg orally every 4-6 hours for 5 days. A retrospective, observational study in a larger group of patients undergoing the same surgery shows that giving the same mesoglycan regimen in conjunction with the ketorolac regimen reduces pain on postoperative day 1 and after 1, 3, and 6 weeks of follow-up when compared with the ketorolac regimen alone. The addition of mesoglycan also reduces the incidence of postoperative rectal thromboses and the time to recovery of normal activities, but does not reduce postoperative bleeding or time to wound healing, when compared with ketorolac alone.

Sources Ref 103263 Ref 109651
Insufficient Reliable Evidence To Rate Tinnitus
Rating & evidence shown verbatim from Natural Medicines

Observational research in patients with tinnitus has found that taking mesoglycan 50 mg daily for 90 days is associated with an improvement in tinnitus when compared to baseline. The validity of this finding is limited by the lack of a comparator group .

Sources Ref 103264
Insufficient Reliable Evidence To Rate Vertigo
Rating & evidence shown verbatim from Natural Medicines

Observational research in patients with vertigo has found that taking mesoglycan 50 mg daily for 90 days is associated with an improvement in vertigo symptoms when compared to baseline. The validity of this finding is limited by the lack of a comparator group.

Sources Ref 103264

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

In the studies done so far, mesoglycan has generally been tolerated fairly well. However, long-term safety data are limited, and it is not a well-known product in many countries.

Because mesoglycan can affect blood clotting, use extra caution if you have a bleeding disorder, are scheduled for surgery, or take medicines or supplements that thin the blood. Stop use and tell your surgeon before any planned procedure.

People with allergies to animal-derived products should be aware that mesoglycan typically comes from pig tissue.

Pregnancy and breastfeeding: There is not enough information to know if mesoglycan is safe during pregnancy or while breastfeeding. To be safe, avoid it during these times unless your doctor specifically advises otherwise.

Always check with your pharmacist or doctor before starting mesoglycan, especially if you have a health condition or take other medicines.

Side effects

Reported side effects are usually mild and may include:

  • Stomach upset, nausea, or heartburn
  • Mild diarrhea or other digestive complaints

Because mesoglycan is related to blood-thinning compounds, there is a possible risk of easy bruising or bleeding, though this is not common at typical doses. Allergic reactions are possible, especially in people sensitive to animal products. Seek medical help right away for signs of a serious allergic reaction such as swelling, trouble breathing, or unusual bleeding.

Mesoglycan: Reported Adverse Effects

Documented safety reports on Mesoglycan from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, mesoglycan seems to be well tolerated. Some adverse effects reported in clinical studies include nausea, vomiting, epigastric pain, dyspepsia, heartburn, headache, diarrhea, and local cutaneous reactions.

However, there is some concern about potential contamination. Mesoglycan is derived from raw animal tissues gathered from slaughterhouses, possibly from sick or diseased animals. Products made from contaminated or diseased organs might present a human health hazard. There is also concern that mesoglycan produced from cows in countries where bovine spongiform encephalitis (BSE) has been reported might be unsafe. However, there are no reports of disease transfer to humans from contaminated mesoglycan.

  1. Raso AM, Maggio D, Trogolo M, et al. [Effectiveness of mesoglycan therapy in patients with ischemia of the lower limbs. Preliminary results of a new therapeutic protocol]. Minerva Cardioangiol 1997;45:383-92.
  2. Viliani T, Scarselli M, Pieri A, Gatti M, Santini M, Pasquetti P. Pharmacological treatment of mechanical edema: a randomized controlled trial about the effects of mesoglycan. Eur J Phys Rehabil Med. 2009;45(1):21-9.
  3. Gossetti B, Antignani PL, Jabbour J, Martinelli O. Flow-mediated dilation benefits of mesoglycan in peripheral artery disease. Int Angiol. 2015;34(4):398-406.
  4. Valvano A, Bosso G, Apuzzi V, Riccone F, Saccá L, Oliviero U. Mesoglycan improves vascular reactivity and insulin sensitivity in patients with metabolic syndrome. Atherosclerosis. 2015;243(2):407-13.
  5. Nationwide alert on hallmark labs injectable adrenal cortex extract. FDA. Available at: www.fda.gov/bbs/topics/NEWS/NEW00539.html
  6. Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
Reports by condition
Alopecia Dermatologic

Orally, mesoglycan has been reported to cause local cutaneous reactions.

Subcutaneously, injections of mesoglycan into the scalp were thought to result in edema, redness, and local hair loss in a 32-year-old female.

  1. Duque-Estrada B, Vincenzi C, Misciali C, Tosti A. Alopecia secondary to mesotherapy. J Am Acad Dermatol. 2009;61(4):707-9.
Cluster headache Neurologic/CNS

Orally, mesoglycan has been reported to cause headache.

  1. Raso AM, Maggio D, Trogolo M, et al. [Effectiveness of mesoglycan therapy in patients with ischemia of the lower limbs. Preliminary results of a new therapeutic protocol]. Minerva Cardioangiol 1997;45:383-92.
Diarrhea Gastrointestinal

Orally, mesoglycan has been reported to cause nausea, vomiting, epigastric pain, dyspepsia, heartburn, and diarrhea.

  1. Raso AM, Maggio D, Trogolo M, et al. [Effectiveness of mesoglycan therapy in patients with ischemia of the lower limbs. Preliminary results of a new therapeutic protocol]. Minerva Cardioangiol 1997;45:383-92.
  2. Gossetti B, Antignani PL, Jabbour J, Martinelli O. Flow-mediated dilation benefits of mesoglycan in peripheral artery disease. Int Angiol. 2015;34(4):398-406.
  3. Valvano A, Bosso G, Apuzzi V, Riccone F, Saccá L, Oliviero U. Mesoglycan improves vascular reactivity and insulin sensitivity in patients with metabolic syndrome. Atherosclerosis. 2015;243(2):407-13.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no official, standardized dose of mesoglycan, and products can differ from one another. In studies it has been given by mouth in divided daily doses, and sometimes by injection in medical settings.

If you use a mesoglycan product, follow the directions on the label and do not exceed the recommended amount. Because the right dose for any given person is not well established, it is best to check with your pharmacist or doctor first to make sure it is appropriate for you.

Pregnancy & Breastfeeding

Mesoglycan & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Mesoglycan & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 26 references that drive our Mesoglycan monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
  2. Nationwide alert on hallmark labs injectable adrenal cortex extract. FDA. Available at: www.fda.gov/bbs/topics/NEWS/NEW00539.html
  3. Laurora G, Cesarone MR, Belcaro G, et al. [Control of the progress of arteriosclerosis in high risk subjects treated with mesoglycan. Measuring the intima media]. Minerva Cardioangiol 1998;46:41-7.
  4. Raso AM, Maggio D, Trogolo M, et al. [Effectiveness of mesoglycan therapy in patients with ischemia of the lower limbs. Preliminary results of a new therapeutic protocol]. Minerva Cardioangiol 1997;45:383-92.
  5. Blardi P, Messa G, Puccetti L, et al. [Effects on the coagulation-fibrinolysis system of a single oral dose of mesoglycan at the beginning and at the end of a prolonged treatment in man]. Recenti Prog Med 1995;86:282-9.
  6. Lotti T, Celasco G, Tsampau D, et al. Mesoglycan treatment restores defective fibrinolytic potential in cutaneous necrotizing venulitis. Int J Dermatol 1993;32:368-71. PubMed
  7. Ambrosio LA, Marchese G, Filippo A, et al. The effect of mesoglycan in patients with cerebrovascular disease: a psychometric evaluation. J Int Med Res 1993;21:138-46. PubMed
  8. Orlandi G, Viapiano F, Massetani R, et al. Clinical-instrumental evaluation of the effects of mesoglycan sulphate in chronic vascular encephalopathy. Acta Neurol (Napoli) 1991;13:255-60.
  9. Abate G, Berenga A, Caione F, et al. [Controlled multicenter study on the therapeutic effectiveness of mesoglycan in patients with cerebrovascular disease]. Minerva Med 1991;82:101-5.
  10. Prandoni P, Cattelan AM, Carta M. [Long-term sequelae of deep venous thrombosis of the legs. Experience with mesoglycan]. Ann Ital Med Int 1989;4:378-85.
  11. Cazzato G, Zorzon M, Mase G, et al. [Mesoglycan in acute focal cerebral ischemia]. Riv Neurol 1989;59:121-6.
  12. Vittoria A, Messa GL, Frigerio C, et al. Effect of a single dose of mesoglycan on the human fibrinolytic system, and the profibrinolytic action of nine daily doses. Int J Tissue React 1988;10:261-6.
  13. Postiglione A, De Simone B, Rubba P, et al. Effect of oral mesoglycan on plasma lipoprotein concentration and on lipoprotein lipase activity in primary hyperlipoproteinemia. Pharmacol Res Commun 1984;16:1-8. PubMed
  14. Arosio E, Ferrari G, Santoro L, et al. A placebo-controlled, double-blind study of mesoglycan in the treatment of chronic venous ulcers. Eur J Vasc Endovasc Surg 2001;22:365-72. PubMed
  15. Nenci, G. G., Gresele, P., Ferrari, G., Santoro, L., and Gianese, F. Treatment of intermittent claudication with mesoglycan--a placebo-controlled, double-blind study. Thromb.Haemost. 2001;86(5):1181-1187. DOI
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Pharmacist Counseling Corner

Mesoglycan: Common Questions

What is Mesoglycan used for, and does it work?
People use Mesoglycan for many reasons, but the evidence varies by use. According to the Natural Medicines database, there is at least some clinical evidence supporting Mesoglycan for Cerebrovascular disease, Peripheral arterial disease (PAD) and Venous leg ulcers. For most other uses it has been studied for, the evidence is currently insufficient to rate. See the graded list on this page, and always confirm with your pharmacist or doctor.
Does Mesoglycan interact with prescription medications?
Yes. We list 122 medications with a known interaction with Mesoglycan. Use the checker above to see how Mesoglycan interacts with a specific drug.
How are Mesoglycan interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Mesoglycan with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Mesoglycan interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Mesoglycan used for?
People mainly use Mesoglycan for vein and circulation problems, such as chronic venous insufficiency, leg ulcers, and poor leg circulation. The evidence supporting these uses is limited.
Is Mesoglycan a plant or herb?
No. Mesoglycan is not a herb. It is a mixture of natural sugar-protein compounds (glycosaminoglycans) usually taken from the intestinal lining of pigs.
Is Mesoglycan safe to take?
It has been tolerated fairly well in studies, but long-term safety data are limited and it can affect blood clotting. Talk to your pharmacist or doctor before using it, especially if you have a bleeding problem or upcoming surgery.
Can I take Mesoglycan while pregnant or breastfeeding?
There is not enough safety information, so it is best to avoid Mesoglycan during pregnancy and breastfeeding unless your doctor advises otherwise.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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