Drug & supplement interaction

Mesoglycan + reteplase

reteplase brand name: Retevase.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

reteplase falls into 2 drug categories that Mesoglycan can interact with; the most serious is rated moderate. Theoretically, combined use might increase bleeding risk.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Mesoglycan and reteplase

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Mesoglycan interacts with whole categories of medication. reteplase falls into 2 of those categories, so it can interact with Mesoglycan in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

1 of 2

Why this applies to reteplase

reteplase falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Mesoglycan interacts with.

Theoretically, combined use might increase bleeding risk. However, human evidence suggests that mesoglycan has profibrinolytic activity without affecting coagulation. These agents include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.
Severity Moderate Likelihood Possible Evidence B

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Reteplase is a powerful clot-busting drug (a thrombolytic) given in the hospital during emergencies like a heart attack. Its whole job is to break down clots fast, which naturally raises bleeding risk on its own. Mesoglycan contains compounds related to heparin and may also nudge your body toward breaking down clots more easily, so the concern here is that stacking them could add to that bleeding tendency.

The good news: human studies suggest mesoglycan mostly boosts clot breakdown without strongly thinning the blood, so this concern is largely theoretical. Still, since reteplase is an emergency medication used under close monitoring, your care team needs to know about any supplement you take. Please tell your doctor or pharmacist about mesoglycan before any procedure.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Blardi P, Messa G, Puccetti L, et al. [Effects on the coagulation-fibrinolysis system of a single oral dose of mesoglycan at the beginning and at the end of a prolonged treatment in man]. Recenti Prog Med 1995;86:282-9.
  2. Vittoria A, Messa GL, Frigerio C, et al. Effect of a single dose of mesoglycan on the human fibrinolytic system, and the profibrinolytic action of nine daily doses. Int J Tissue React 1988;10:261-6.
  3. Messa, G., Blardi, P., La Placa, G., Puccetti, L., and Ghezzi, A. [Effects of 2 single oral doses of mesoglycan on the coagulation-fibrinolysis system in man. A pharmacodynamic study]. Recenti Prog.Med. 1995;86(7-8):272-281.
Moderate

THROMBOLYTIC DRUGS

2 of 2

reteplase also falls under THROMBOLYTIC DRUGS.

Theoretically, combined use might increase bleeding risk. These drugs include alteplase (Activase), anistreplase (Eminase), reteplase (Retevase), streptokinase (Streptase), and urokinase (Abbokinase).
Severity Moderate Likelihood Possible Evidence B

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Reteplase is a powerful clot-busting medicine given in the hospital during emergencies like a heart attack. It works by actively dissolving blood clots, so bleeding is already its main risk. Mesoglycan has a mild blood-thinning effect of its own because some of its compounds are related to heparin. Stacking the two together could, in theory, push that bleeding risk higher.

In practice, reteplase is only used in tightly monitored hospital settings, and your care team will already know everything in your system. This concern is mostly theoretical and based on limited evidence, so don't panic. Still, always tell your doctor or pharmacist about any supplements like mesoglycan, especially before a planned procedure.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Raso AM, Maggio D, Trogolo M, et al. [Effectiveness of mesoglycan therapy in patients with ischemia of the lower limbs. Preliminary results of a new therapeutic protocol]. Minerva Cardioangiol 1997;45:383-92.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Mesoglycan Also Interacts With Other Medications

Mesoglycan has 121 moderate known drug interactions in our database — the reteplase one above is among them. If you take anything else, check it against the full list below.

Moderate 121 No known interaction 2,709 (incl. reteplase)
Taking anything else?

Check Another of Your Medications Against Mesoglycan

Covers the 2,830 medications we’ve checked against Mesoglycan. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With reteplase

This page covers Mesoglycan only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the reteplase page lists 219 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Danshen (major), Piracetam (major), Aconite (moderate) and Allspice (moderate).

By severity: 3 major · 191 moderate · 25 minor.

Open the reteplase interaction page

How much people look this up

Where Mesoglycan and reteplase Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Mesoglycan
Top half

#507 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication reteplase
Top half

#740 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Mesoglycan

What is Mesoglycan?

  • Vein health and chronic venous insufficiency
  • Leg ulcers
  • Peripheral artery disease and leg pain
  • Reducing blood clot risk
  • Hemorrhoids

Mesoglycan is a blend of natural sugar-protein compounds (glycosaminoglycans, including heparan sulfate and dermatan sulfate) taken from animal tissue and used mainly for blood vessel and circulation problems. Some small studies suggest possible benefit for vein-related conditions, but the overall evidence is limited and not strong. Because it can affect blood clotting, talk to your doctor or pharmacist before using it.

Read the full Mesoglycan monograph & all interactions
Keep checking

Other Drugs & Mesoglycan

Browse every other medication we’ve checked against Mesoglycan — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
121Moderate
0Minor
2,708No known interaction
121 Moderate 2,708 No interaction
Moderate

121 interactions

Showing 60 of 121 moderate interactions — see all 121 on the Mesoglycan page.

No interaction 2,708 drugs checked — show the list

We also checked Mesoglycan against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,708 medications checked with no known interaction — see the full Mesoglycan list.

See the full Mesoglycan interactions page
See every supplement checked against reteplase, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Mesoglycan monograph › Uses, safety, and every drug interaction in one place reteplase supplement interactions › Every supplement checked against reteplase, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Mesoglycan and reteplase Together: Common Questions

Can you take Mesoglycan with reteplase?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Mesoglycan and reteplase?
reteplase belongs to more than one drug category, and Mesoglycan interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Mesoglycan and reteplase interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About reteplase and Mesoglycan?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.