Drug & supplement interaction

Mesoglycan + Metoprolol

Metoprolol brand names: Lopressor, Toprol XL.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Mesoglycan and Metoprolol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Metoprolol states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Mesoglycan and Metoprolol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Metoprolol and Mesoglycan in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Mesoglycan safety at a glance

Mesoglycan overall Use caution Generally tolerated in studies, but it can affect blood clotting and lacks long-term safety data.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Metoprolol and Mesoglycan? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Metoprolol

Interactions in our licensed database are recorded against drug classes, not just single drug names. Metoprolol is filed under 6 classifications — including beta-blockers, antihypertensive drugs, cytochrome p450 2d6 (cyp2d6) substrates. Mesoglycan has documented interactions with 2 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate) and thrombolytic drugs (moderate) — and none of Metoprolol’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Mesoglycan Does Interact With Other Medications

Mesoglycan has 122 moderate known drug interactions in our database — Metoprolol isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Metoprolol)
Taking anything else?

Check Another of Your Medications Against Mesoglycan

Covers the 2,830 medications we’ve checked against Mesoglycan. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Mesoglycan and Metoprolol May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Heartburn / Diarrhea / Vomiting / Nausea Additional detail

    Mesoglycan

    “Orally, mesoglycan seems to be well tolerated. Some adverse effects reported in clinical studies include nausea, vomiting, epigastric pain, dyspepsia, heartburn, headache, diarrhea, and local cutaneous reactions.

    However, there is some concern about potential contamination. Mesoglycan is derived from raw animal tissues gathered from slaughterhouses, possibly from sick or diseased animals.”

    Mesoglycan · Natural Medicines adverse-effect record, reported in cluster headache.

    6 sources cited
    1. 6629. Raso AM, Maggio D, Trogolo M, et al. [Effectiveness of mesoglycan therapy in patients with ischemia of the lower limbs. Preliminary results of a new therapeutic protocol]. Minerva Cardioangiol 1997;45:383-92.
    2. 97778. Viliani T, Scarselli M, Pieri A, Gatti M, Santini M, Pasquetti P. Pharmacological treatment of mechanical edema: a randomized controlled trial about the effects of mesoglycan. Eur J Phys Rehabil Med. 2009;45(1):21-9.
    3. 97779. Gossetti B, Antignani PL, Jabbour J, Martinelli O. Flow-mediated dilation benefits of mesoglycan in peripheral artery disease. Int Angiol. 2015;34(4):398-406.
    4. 103265. Valvano A, Bosso G, Apuzzi V, Riccone F, Saccá L, Oliviero U. Mesoglycan improves vascular reactivity and insulin sensitivity in patients with metabolic syndrome. Atherosclerosis. 2015;243(2):407-13. PubMed
    5. 6620. Nationwide alert on hallmark labs injectable adrenal cortex extract. FDA. Available at: www.fda.gov/bbs/topics/NEWS/NEW00539.html
    6. 1825. Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.

    “Orally, mesoglycan has been reported to cause nausea, vomiting, epigastric pain, dyspepsia, heartburn, and diarrhea.”

    Mesoglycan · Natural Medicines adverse-effect record, reported in diarrhea.

    3 sources cited
    1. 6629. Raso AM, Maggio D, Trogolo M, et al. [Effectiveness of mesoglycan therapy in patients with ischemia of the lower limbs. Preliminary results of a new therapeutic protocol]. Minerva Cardioangiol 1997;45:383-92.
    2. 97779. Gossetti B, Antignani PL, Jabbour J, Martinelli O. Flow-mediated dilation benefits of mesoglycan in peripheral artery disease. Int Angiol. 2015;34(4):398-406.
    3. 103265. Valvano A, Bosso G, Apuzzi V, Riccone F, Saccá L, Oliviero U. Mesoglycan improves vascular reactivity and insulin sensitivity in patients with metabolic syndrome. Atherosclerosis. 2015;243(2):407-13. PubMed

    Metoprolol

    Listed in the ADVERSE REACTIONS section of the FDA label for Metoprolol. Read the label on DailyMed ›

  • Hair loss / Swelling Additional detail

    Mesoglycan

    “Orally, mesoglycan has been reported to cause local cutaneous reactions.

    Subcutaneously, injections of mesoglycan into the scalp were thought to result in edema, redness, and local hair loss in a 32-year-old female.”

    Mesoglycan · Natural Medicines adverse-effect record, reported in alopecia.

    1 source cited
    1. 97780. Duque-Estrada B, Vincenzi C, Misciali C, Tosti A. Alopecia secondary to mesotherapy. J Am Acad Dermatol. 2009;61(4):707-9. PubMed

    Metoprolol

    Listed in the ADVERSE REACTIONS section of the FDA label for Metoprolol. Read the label on DailyMed ›

  • Headache Additional detail

    Mesoglycan

    “Orally, mesoglycan has been reported to cause headache.”

    Mesoglycan · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 6629. Raso AM, Maggio D, Trogolo M, et al. [Effectiveness of mesoglycan therapy in patients with ischemia of the lower limbs. Preliminary results of a new therapeutic protocol]. Minerva Cardioangiol 1997;45:383-92.

    Metoprolol

    Listed in the ADVERSE REACTIONS section of the FDA label for Metoprolol. Read the label on DailyMed ›

Reported for Mesoglycan but not commonly for Metoprolol: stomach upset.

Effects for Metoprolol come from the ADVERSE REACTIONS section of its FDA label; effects for Mesoglycan come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Metoprolol Products Have a Food Rule — Mesoglycan Should Not Break It

At least one FDA label for a product containing Metoprolol says to take it with food. If you take Mesoglycan on an empty stomach out of habit, keep them separate — and take Metoprolol with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Metoprolol products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Administer once daily with food or after a meal.

From the Dosage and Administration section of the FDA label we read for Metoprolol — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Overlapping uses

What Metoprolol Is Prescribed For, and What Mesoglycan Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Metoprolol is a prescription medicine with approved uses on its FDA label. Mesoglycan is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Metoprolol is prescribed for: Metoprolol is used to treat several heart and blood pressure conditions. Metoprolol succinate extended-release tablets (including Toprol-XL) are approved for high blood pressure, angina pectoris (chest pain from the heart), and heart failure. Metoprolol tartrate tablets (including Lopressor) are approved for high blood pressure, angina, and — when used alongside intravenous metoprolol — to reduce the risk of cardiovascular death after a definite or suspected heart attack. Metoprolol tartrate injection (intravenous form) is used in hemodynamically stable patients with a definite or suspected acute heart attack to reduce cardiovascular death, and is followed by oral metoprolol therapy.

Read the rest of what Metoprolol is prescribed for

Lowering blood pressure with metoprolol reduces the risk of strokes and heart attacks.

Mesoglycan has been studied for:

  • Stroke studied, not established Mesoglycan has been studied for this. Natural Medicines rates the evidence: Possibly Ineffective Read what the research shows

    Mesoglycan for stroke

    Clinical research in patients with acute ischemic stroke shows that adding intramuscular mesoglycan for 5 days, followed by 25 days of oral mesoglycan, to intravenous dexamethasone therapy is no more effective than dexamethasone alone.

    1 source cited
    1. 6641. Cazzato G, Zorzon M, Mase G, et al. [Mesoglycan in acute focal cerebral ischemia]. Riv Neurol 1989;59:121-6.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Metoprolol on your own; if you are taking Mesoglycan for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Mesoglycan or Metoprolol

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Mesoglycan or Metoprolol, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Metoprolol

This page covers Mesoglycan only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Metoprolol page lists 183 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Indian Snakeroot (major) and Tyramine (major).

By severity: 5 major · 152 moderate · 26 minor.

From our pharmacist’s overview on the Metoprolol page

“With metoprolol (Lopressor, Toprol XL), a beta-blocker for high blood pressure and heart problems, these interactions deserve genuine care, starting with the five rated major. Most entries pull blood pressure one way or the other: many supplements add to metoprolol's lowering effect and can drop pressure too far, while a few, tyramine…”

Reviewed by 2 · Jul 18, 2026

Open the Metoprolol interaction page

How much people look this up

Where Mesoglycan and Metoprolol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Mesoglycan
Top half

#527 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Metoprolol
Top 10

#7 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Mesoglycan reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Mesoglycan and Metoprolol records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Mesoglycan

What is Mesoglycan?

  • Vein health and chronic venous insufficiency
  • Leg ulcers
  • Peripheral artery disease and leg pain
  • Reducing blood clot risk
  • Hemorrhoids

Mesoglycan is a blend of natural sugar-protein compounds (glycosaminoglycans, including heparan sulfate and dermatan sulfate) taken from animal tissue and used mainly for blood vessel and circulation problems. Some small studies suggest possible benefit for vein-related conditions, but the overall evidence is limited and not strong. Because it can affect blood clotting, talk to your doctor or pharmacist before using it.

Glycosaminoglycans extracted from porcine (pig) intestinal mucosa · Tablets, capsules

An interaction check asks whether these two react with each other — it does not ask whether Mesoglycan is a good idea for someone in your situation. Here is what our Mesoglycan record says about it on its own.

Mesoglycan: dosing

There is no official, standardized dose of mesoglycan, and products can differ from one another. In studies it has been given by mouth in divided daily doses, and sometimes by injection in medical settings.If you use a mesoglycan product, follow the directions on the label and do not exceed the recommended amount.

From our Mesoglycan monograph — the full record covers uses, side effects and every documented interaction.

Read the full Mesoglycan monograph & all interactions
Medication

About Metoprolol

What Is Metoprolol Used For?

Brand names: Lopressor, Toprol XL

Metoprolol is used to treat several heart and blood pressure conditions. Metoprolol succinate extended-release tablets (including Toprol-XL) are approved for high blood pressure, angina pectoris (chest pain from the heart), and heart failure. Metoprolol tartrate tablets (including Lopressor) are approved for high blood pressure, angina, and — when used alongside intravenous metoprolol — to reduce the risk of cardiovascular death after a definite or suspected heart attack.

Metoprolol tartrate injection (intravenous form) is used in hemodynamically stable patients with a definite or suspected acute heart attack to reduce cardiovascular death, and is followed by oral metoprolol therapy. Lowering blood pressure with metoprolol reduces the risk of strokes and heart attacks.

Most-Reported Side Effects for Metoprolol

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 23,416 reports
Dyspnea 20,183 reports
Diarrhea 19,912 reports
Nausea 19,659 reports
Dizziness 16,726 reports
See full Metoprolol drug information
Keep checking

Other Drugs & Mesoglycan

Browse every other medication we’ve checked against Mesoglycan — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Mesoglycan page.

No interaction 2,707 drugs checked — show the list

We also checked Mesoglycan against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Mesoglycan list.

See the full Mesoglycan interactions page
See every supplement checked against Metoprolol, ranked by severity
Evidence & sources

Mesoglycan References

The 26 references that drive our Mesoglycan monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
  2. Nationwide alert on hallmark labs injectable adrenal cortex extract. FDA. Available at: www.fda.gov/bbs/topics/NEWS/NEW00539.html
  3. Laurora G, Cesarone MR, Belcaro G, et al. [Control of the progress of arteriosclerosis in high risk subjects treated with mesoglycan. Measuring the intima media]. Minerva Cardioangiol 1998;46:41-7.
  4. Raso AM, Maggio D, Trogolo M, et al. [Effectiveness of mesoglycan therapy in patients with ischemia of the lower limbs. Preliminary results of a new therapeutic protocol]. Minerva Cardioangiol 1997;45:383-92.
  5. Blardi P, Messa G, Puccetti L, et al. [Effects on the coagulation-fibrinolysis system of a single oral dose of mesoglycan at the beginning and at the end of a prolonged treatment in man]. Recenti Prog Med 1995;86:282-9.
  6. Lotti T, Celasco G, Tsampau D, et al. Mesoglycan treatment restores defective fibrinolytic potential in cutaneous necrotizing venulitis. Int J Dermatol 1993;32:368-71. PubMed
  7. Ambrosio LA, Marchese G, Filippo A, et al. The effect of mesoglycan in patients with cerebrovascular disease: a psychometric evaluation. J Int Med Res 1993;21:138-46. PubMed
  8. Orlandi G, Viapiano F, Massetani R, et al. Clinical-instrumental evaluation of the effects of mesoglycan sulphate in chronic vascular encephalopathy. Acta Neurol (Napoli) 1991;13:255-60.
  9. Abate G, Berenga A, Caione F, et al. [Controlled multicenter study on the therapeutic effectiveness of mesoglycan in patients with cerebrovascular disease]. Minerva Med 1991;82:101-5.
  10. Prandoni P, Cattelan AM, Carta M. [Long-term sequelae of deep venous thrombosis of the legs. Experience with mesoglycan]. Ann Ital Med Int 1989;4:378-85.
  11. Cazzato G, Zorzon M, Mase G, et al. [Mesoglycan in acute focal cerebral ischemia]. Riv Neurol 1989;59:121-6.
  12. Vittoria A, Messa GL, Frigerio C, et al. Effect of a single dose of mesoglycan on the human fibrinolytic system, and the profibrinolytic action of nine daily doses. Int J Tissue React 1988;10:261-6.
  13. Postiglione A, De Simone B, Rubba P, et al. Effect of oral mesoglycan on plasma lipoprotein concentration and on lipoprotein lipase activity in primary hyperlipoproteinemia. Pharmacol Res Commun 1984;16:1-8. PubMed
  14. Arosio E, Ferrari G, Santoro L, et al. A placebo-controlled, double-blind study of mesoglycan in the treatment of chronic venous ulcers. Eur J Vasc Endovasc Surg 2001;22:365-72. PubMed
  15. Nenci, G. G., Gresele, P., Ferrari, G., Santoro, L., and Gianese, F. Treatment of intermittent claudication with mesoglycan--a placebo-controlled, double-blind study. Thromb.Haemost. 2001;86(5):1181-1187. DOI

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Mesoglycan and Metoprolol Together: Common Questions

Is it safe to take Mesoglycan with Metoprolol?
We do not list a known interaction between Mesoglycan and Metoprolol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Mesoglycan and Metoprolol have any of the same side effects?
Yes — our sources link each of them separately to 7 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Mesoglycan and Metoprolol at the same time of day?
At least one FDA label for a product containing Metoprolol says to take it with food. If you take Mesoglycan on an empty stomach out of habit, keep them separate and take Metoprolol with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Metoprolol products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Are Mesoglycan and Metoprolol used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Mesoglycan in each. That is a conversation for your prescriber, especially if Metoprolol is being adjusted to a target.
How was the Mesoglycan and Metoprolol combination checked?
Interactions in our licensed database are recorded against drug classes. Metoprolol is filed under 6 classifications, and Mesoglycan has documented interactions with 2 drug classes — none of Metoprolol's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Mesoglycan interact with any other medications?
Yes. Mesoglycan has 122 documented drug interactions in our database — Metoprolol is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Metoprolol interact with any supplements?
Yes. Metoprolol has documented interactions with 183 supplements in our database — Mesoglycan is not one of them. The Metoprolol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Mesoglycan monograph Uses, safety profile, and every drug interaction in one place Metoprolol drug information The full plain-English guide to this medication Metoprolol supplement interactions Every supplement checked against Metoprolol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 26 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.