Herb & supplement monograph

Jackfruit Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Jackfruit interacts with medications. The heart of this page is the interaction list — every drug Jackfruit is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Jackfruit is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

Check Jackfruit against your medication

Add one medication
Jackfruit
+
Start typing any prescription or over-the-counter drug name.
Reviewed by licensed pharmacists Sourced from Natural Medicines
On this page

Jackfruit Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Jackfruit drug interaction appears low for most people. None of the listed interactions are rated major, and all of them rest on limited or theoretical evidence rather than well-documented human studies.

Interactions deserving the most attention

The interaction with the most real-world backing involves diabetes medications. Small human studies show jackfruit flour and leaf extract can lower blood sugar, so combining the two could push blood sugar lower than expected, and glucose is worth watching closely. There is also a theoretical concern with anticoagulant and antiplatelet drugs, since lab research suggests jackfruit latex, the sap from the bark, may affect clotting, though this has not been shown in people. Animal studies hint that jackfruit seeds could add to the drowsiness caused by sedating medications.

What the rest of the list means

Jackfruit is linked to a long list of medications, but that number reflects how many drugs fall into a few broad categories, not hundreds of separate proven problems. Most of these concerns come from lab or animal research and have not been confirmed to cause meaningful changes in people. For someone eating jackfruit as an ordinary food, a noticeable effect on their medications is unlikely.

Check your medications against Jackfruit

Based on HelloPharmacist’s Jackfruit interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Jackfruit

437 medications have a known interaction with Jackfruit, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
AbciximabReoPro› AbrocitinibCibinqo› AcarboseGlucobay, Prandase, Precose› AcenocoumarolSintrom› AcepromazineAtravet› Acetaminophen, AspirinGemnisyn› Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine› Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine› Acetaminophen, Butalbital, CodeineBancap w/ Codeine› Acetaminophen, Butalbital, Codeine PhosphatePhrenilin #3› Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound› Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more› Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3› Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS› Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex› Acetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule› Acetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8› Acetaminophen, CodeineTylenol No.3, Tylenol w/ Codeine› Acetaminophen, Codeine, DoxylamineMersyndol› Acetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8› Acetaminophen, Dichloralantipyrine, IsomethepteneAmidrine, Midchlor, Migquin, Migratine› Acetaminophen, Dichloralphenazone, IsomethepteneMidrin› Acetaminophen, Dichlorophenazone, IsometheptaneIsocom› Acetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength› Acetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief› Acetaminophen, HydrocodoneAnexsia, Anodynos DHC, Azdone, Co-Gesic, Doucet, Lorcet +9 more› Acetaminophen, IbuprofenCombogesic› Acetaminophen, MeperidineDemerol APAP› Acetaminophen, OxycodonePercocet, Roxicet, Tylox, Xartemis XR› Acetaminophen, PentazocineTalacen›
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Jackfruit combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Jackfruit affects

Every type of medication (drug category) Jackfruit is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 3 drug categories Jackfruit interacts with
Anticoagulant/antiplatelet DrugsAntidiabetes DrugsCns Depressants
Anticoagulant/Antiplatelet Drugs

Theoretically, jackfruit latex might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Jackfruit latex, which is the sap from jackfruit bark, contains chemicals that might increase the risk of bleeding. In vitro research shows that jackfruit latex contains a glycoprotein constituent that prolongs the activated partial thrombin time (aPTT) and reduces the activity of blood coagulation factors XIa and alpha-XIIa. Jackfruit latex also contains a protease constituent that has been shown to have fibrinolytic activity in vitro. Other parts of jackfruit, including the fruit and leaves, have not been shown to contain chemicals with fibrinolytic and anticoagulant activity.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, jackfruit might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies show that jackfruit flour and leaf extract can reduce fasting and postprandial blood glucose. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, jackfruit seeds might cause additive sedation when taken with CNS depressants.
Animal research shows that jackfruit seeds can cause sedation.

Likelihood Possible Evidence D
Monograph

Jackfruit: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Jackfruit is a large tropical fruit that is nutritious and safe to eat as a food, offering fiber, vitamin C, potassium, and antioxidants. While its leaves, seeds, and other parts are used in traditional medicine for things like blood sugar and digestion, strong human evidence for these supplement uses is limited. Talk to your pharmacist or doctor before using concentrated jackfruit products for a health condition.

Jackfruit
Scientific name
Artocarpus heterophyllus
Family
Moraceae
Part used
Fruit, seeds, leaves, bark, roots, and latex
Common forms
Fresh or canned fruit, dried fruit, flour, seeds, capsules, powder, and leaf or bark extracts
People commonly use it for
  • General nutrition
  • Blood sugar support
  • Digestive health (fiber)
  • Antioxidant support
  • Wound care (traditional, latex/leaves)

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallLikely safe

The ripe fruit is widely eaten and generally safe as a food for most people.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid amounts in excess of those found in foods.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid amounts in excess of those found in foods.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Jackfruit (Artocarpus heterophyllus) is a large tropical fruit native to India and other parts of South and Southeast Asia. It is often called the largest tree-borne fruit in the world, and a single fruit can weigh many pounds. The fruit has a thick, bumpy green skin and a sweet, slightly musky yellow flesh.

People eat jackfruit fresh, dried, or cooked. Unripe (young) jackfruit has a meaty texture and is popular as a plant-based meat substitute in many recipes. The seeds can also be cooked and eaten. Beyond the kitchen, the leaves, bark, roots, and milky latex of the jackfruit tree have a long history of use in traditional medicine.

How it works

Jackfruit contains fiber, vitamins, minerals, and plant compounds such as flavonoids and carotenoids that act as antioxidants. Antioxidants may help protect cells from damage caused by unstable molecules called free radicals.

Some lab and animal research suggests certain jackfruit compounds may slow the breakdown of carbohydrates or affect how the body handles sugar, which is the basis for its traditional use in blood sugar support. The fiber in the fruit can also help with digestion and promote a feeling of fullness.

It is important to remember that most of these effects come from laboratory or animal studies, not large human trials, so we cannot be sure how well they apply to people.

Effectiveness

Does Jackfruit work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 2 uses evaluated
2 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Jackfruit, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 2 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Diabetes
Rating & evidence shown verbatim from Natural Medicines

Small clinical studies suggest that oral jackfruit flour or leaf extract might improve glycemic control in patients with diabetes.

Insufficient Reliable Evidence To Rate Wound healing
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using topical jackfruit for wound healing, there is insufficient reliable information about the clinical effects of jackfruit for this purpose.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Jackfruit is widely eaten around the world and is generally considered safe as a food for most people. People who are allergic to birch pollen or natural rubber latex may, in rare cases, react to jackfruit, so caution is wise if you have these allergies.

If you have diabetes, be aware that jackfruit may affect blood sugar; monitor your levels and let your healthcare team know if you eat large amounts or use jackfruit supplements. People with kidney problems should be mindful of jackfruit's potassium content.

For pregnancy and breastfeeding, eating the fruit in normal food amounts is likely fine, but there is not enough reliable safety information on concentrated jackfruit extracts, leaf, or bark preparations. To be safe, avoid medicinal jackfruit products during pregnancy and breastfeeding unless your doctor approves.

Side effects

Jackfruit is usually well tolerated as a food. Eating a lot of it may cause digestive upset such as gas, bloating, or loose stools because of its fiber content.

Allergic reactions are uncommon but possible, especially in people sensitive to latex or birch pollen. Signs of an allergic reaction can include itching, swelling, or trouble breathing—seek medical help right away if these occur. Because jackfruit may lower blood sugar, people taking diabetes medicines should watch for symptoms of low blood sugar.

Jackfruit: Reported Adverse Effects

Documented safety reports on Jackfruit from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Reports by condition
Allergic rhinitis (hay fever) Immunologic

Orally, the fruit of jackfruit might cause serious allergic reactions, including anaphylaxis, in sensitive individuals. In one case report, a 34-year-old female developed anaphylaxis with symptoms of cough, dyspnea, facial swelling, and urticaria after eating 10 pieces of dried jackfruit. There is speculation that latex allergy might result in a cross-reactivity to jackfruit. In another case report, a 21-year-old male developed anaphylaxis with symptoms of ocular pruritis, periorbital swelling, dyspnea, and urticaria 15 minutes after eating a small piece of dried jackfruit. The patient had a history of latex allergy and tested positive for jackfruit and latex allergies upon skin prick testing.

  1. Wongrakpanich S, Klaewsongkram J, Chantaphakul H, Ruxrungtham K. Jackfruit anaphylaxis in a latex allergic patient. Asian Pac J Allergy Immunol. 2015;33(1):65-8.
  2. Jalil M, Hostoffer R, Wu SS. Jackfruit Anaphylaxis in a Latex Allergic Non-Healthcare Worker. Allergy Rhinol (Providence) 2021;12:21526567211009195.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no established standard dose for jackfruit as a supplement. As a food, you can simply enjoy it as part of a balanced diet.

For capsules, powders, or extracts, no proven medicinal dose has been set in research, so follow the directions on the product label. Because product strengths vary and good human data is lacking, it is best to check with your pharmacist or doctor before using concentrated jackfruit products, especially if you have a health condition or take other medicines.

Pregnancy & Breastfeeding

Jackfruit & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid amounts in excess of those found in foods.

Jackfruit & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid amounts in excess of those found in foods.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 7 references that drive our Jackfruit monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Fernando MR, Wickramasinghe N, Thabrew MI, Ariyananda PL, Karunanayake EH. Effect of Artocarpus heterophyllus and Asteracanthus longifolia on glucose tolerance in normal human subjects and in maturity-onset diabetic patients. J Ethnopharmacol 1991;31(3):2 PubMed
  2. Ratnasooriya WD, Jayakody JR. Artocarpus heterophyllus seeds inhibits sexual competence but not fertility of male rats. Indian J Exp Biol 2002;40(3):304-308.
  3. Siritapetawee J, Thammasirirak S. Purification and characterization of a heteromultimeric glycoprotein from Artocarpus heterophylluslatex with an inhibitory effect on human blood coagulation. Acta Biochim Pol. 2011;58(4):521-8.
  4. Siritapetawee J, Thumanu K, Sojikul P, Thammasirirak S. A novel serine protease with human fibrino(geno)lytic activities from Artocarpus heterophylluslatex. Biochim Biophys Acta. 2012;1824(7):907-12.
  5. Wongrakpanich S, Klaewsongkram J, Chantaphakul H, Ruxrungtham K. Jackfruit anaphylaxis in a latex allergic patient. Asian Pac J Allergy Immunol. 2015;33(1):65-8.
  6. Jalil M, Hostoffer R, Wu SS. Jackfruit Anaphylaxis in a Latex Allergic Non-Healthcare Worker. Allergy Rhinol (Providence) 2021;12:21526567211009195. PubMed
  7. Rao AG, Naik KS, Unnikrishnan AG, Joseph J. Efficacy of green jackfruit flour as a medical nutrition therapy replacing rice or wheat in patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled study. Nutr Diabetes 2021;11(1): PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Pharmacist Counseling Corner

Jackfruit: Common Questions

What is Jackfruit used for, and does it work?
People use Jackfruit for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Jackfruit interact with prescription medications?
Yes. We list 437 medications with a known interaction with Jackfruit. Use the checker above to see how Jackfruit interacts with a specific drug.
How are Jackfruit interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Jackfruit with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Jackfruit interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Jackfruit used for?
Most people eat Jackfruit as a nutritious food or as a plant-based meat substitute. In traditional medicine, its leaves, seeds, and bark are used for blood sugar, digestion, and skin care, but strong human evidence for these uses is limited.
Is Jackfruit safe to eat?
Yes, for most people the ripe fruit is safe and nutritious. Eating very large amounts may cause gas or bloating, and people allergic to latex or birch pollen should be cautious.
Can Jackfruit help with diabetes?
Some early lab and animal studies suggest Jackfruit may help with blood sugar, but human evidence is not strong enough to recommend it as a treatment. If you have diabetes, monitor your blood sugar and talk to your healthcare provider.
Is Jackfruit safe during pregnancy?
Eating Jackfruit as a normal food is likely fine, but there is not enough data on concentrated Jackfruit supplements during pregnancy or breastfeeding, so it's best to avoid those unless your doctor approves.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next
Supplement interaction checkerCheck any supplement or product against your medications Drug–drug interactionsCheck two or more of your medications against each other Browse medications A–ZEvery drug we’ve checked against herbs & supplements NDC & pricing lookupFind a drug’s NDCs, packaging and costs Ask a pharmacistFree, personal answer from our licensed team

Have a question about Jackfruit?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist