Drug & supplement interaction

Jackfruit + Acetaminophen, Ibuprofen

Acetaminophen, Ibuprofen brand name: Combogesic.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Jackfruit has a moderate interaction with Acetaminophen, Ibuprofen. Theoretically, jackfruit latex might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Jackfruit and Acetaminophen, Ibuprofen

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Acetaminophen, Ibuprofen

Acetaminophen, Ibuprofen falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Jackfruit interacts with.

Theoretically, jackfruit latex might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Jackfruit latex, which is the sap from jackfruit bark, contains chemicals that might increase the risk of bleeding. In vitro research shows that jackfruit latex contains a glycoprotein constituent that prolongs the activated partial thrombin time (aPTT) and reduces the activity of blood coagulation factors XIa and alpha-XIIa. Jackfruit latex also contains a protease constituent that has been shown to have fibrinolytic activity in vitro. Other parts of jackfruit, including the fruit and leaves, have not been shown to contain chemicals with fibrinolytic and anticoagulant activity.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the deal with Combogesic (the acetaminophen and ibuprofen combo) and jackfruit. The ibuprofen part already nudges up your bleeding risk a little on its own, since it's an NSAID that affects platelets and can irritate the stomach. The concern on file is that jackfruit latex, the sticky sap from the bark, may add to that bleeding tendency.

I want to be honest about how thin this evidence is. It comes from lab studies only, not people, and it points specifically to the latex, not the sweet fruit you'd eat or a normal serving. So eating jackfruit as food shouldn't be a worry. If you're using a concentrated jackfruit product, watch for things like easy bruising, dark or tarry stools, or stomach upset that won't quit, and check in with your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Siritapetawee J, Thammasirirak S. Purification and characterization of a heteromultimeric glycoprotein from Artocarpus heterophylluslatex with an inhibitory effect on human blood coagulation. Acta Biochim Pol. 2011;58(4):521-8.
  2. Siritapetawee J, Thumanu K, Sojikul P, Thammasirirak S. A novel serine protease with human fibrino(geno)lytic activities from Artocarpus heterophylluslatex. Biochim Biophys Acta. 2012;1824(7):907-12.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Jackfruit Also Interacts With Other Medications

Jackfruit has 436 moderate known drug interactions in our database — the Acetaminophen, Ibuprofen one above is one of them. If you take anything else, check it against the full list below.

Moderate 436 No known interaction 2,394 (incl. Acetaminophen, Ibuprofen)
Taking anything else?

Check Another of Your Medications Against Jackfruit

Covers the 2,830 medications we’ve checked against Jackfruit. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Acetaminophen, Ibuprofen

This page covers Jackfruit only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen, Ibuprofen page lists 342 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

By severity: 7 major · 290 moderate · 45 minor.

From our pharmacist’s overview on the Acetaminophen, Ibuprofen page

“Combogesic pairs acetaminophen with ibuprofen, so it inherits the vulnerabilities of both drugs, and its supplement list deserves real attention before you add anything to it. Of the 342 ingredients on file, 7 carry a major rating, and those are the ones to understand first.”

Reviewed by 2 · Jul 18, 2026

Open the Acetaminophen, Ibuprofen interaction page

How much people look this up

Where Jackfruit and Acetaminophen, Ibuprofen Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Jackfruit
Top half

#583 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Acetaminophen, Ibuprofen
Top 10%

#207 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Jackfruit

What is Jackfruit?

Jackfruit
  • General nutrition
  • Blood sugar support
  • Digestive health (fiber)
  • Antioxidant support
  • Wound care (traditional, latex/leaves)

Jackfruit is a large tropical fruit that is nutritious and safe to eat as a food, offering fiber, vitamin C, potassium, and antioxidants. While its leaves, seeds, and other parts are used in traditional medicine for things like blood sugar and digestion, strong human evidence for these supplement uses is limited. Talk to your pharmacist or doctor before using concentrated jackfruit products for a health condition.

Read the full Jackfruit monograph & all interactions
Keep checking

Other Drugs & Jackfruit

Browse every other medication we’ve checked against Jackfruit — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
436Moderate
0Minor
2,393No known interaction
436 Moderate 2,393 No interaction
Moderate

436 interactions

Showing 60 of 436 moderate interactions — see all 436 on the Jackfruit page.

No interaction 2,393 drugs checked — show the list

We also checked Jackfruit against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,393 medications checked with no known interaction — see the full Jackfruit list.

See the full Jackfruit interactions page
See every supplement checked against Acetaminophen, Ibuprofen, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Jackfruit monograph › Uses, safety, and every drug interaction in one place Acetaminophen, Ibuprofen supplement interactions › Every supplement checked against Acetaminophen, Ibuprofen, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Jackfruit and Acetaminophen, Ibuprofen Together: Common Questions

Can you take Jackfruit with Acetaminophen, Ibuprofen?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Jackfruit and Acetaminophen, Ibuprofen interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Acetaminophen, Ibuprofen and Jackfruit?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.