Medication interaction hub

What Supplements Interact with Acetaminophen, Ibuprofen?

Acetaminophen, Ibuprofen brand name: Combogesic. Every interaction below applies to the brands too.

342 Interactions 7 Major 290 Moderate 45 Minor
Curated & coded by · Clinical Pharmacist · Updated September 27, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Acetaminophen, Ibuprofen? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Acetaminophen, Ibuprofen against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Combogesic pairs acetaminophen with ibuprofen, so it inherits the vulnerabilities of both drugs, and its supplement list deserves real attention before you add anything to it. Of the 342 ingredients on file, 7 carry a major rating, and those are the ones to understand first. The single biggest pattern involves bleeding. More than 200 of these ingredients can thin the blood or slow clotting, which stacks on top of ibuprofen's own bleeding risk. Alcohol belongs here too, since beer and wine both carry major ratings for stomach bleeding.

The other serious themes track each half of the tablet. A few dozen ingredients can stress the liver, acetaminophen's weak point, and a handful strain the kidneys, ibuprofen's. Activated charcoal earns a major rating for a different reason, soaking up medicine before it absorbs, so space it well apart from any dose. Most of the remaining 290 moderate and 45 minor entries shift how your body processes these drugs rather than causing direct harm.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 290 Minor 45 No known interaction 1,110

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Acetaminophen, Ibuprofen: Top Interactions at a Glance

The Acetaminophen, Ibuprofen supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 342 interacting ingredients — plus 1,110 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Acetaminophen, Ibuprofen Combinations Today

The Acetaminophen, Ibuprofen + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Alpha-lipoic Acid + Acetaminophen, Ibuprofeni

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Minor Likelihood Unlikely Fish Oil + Acetaminophen, Ibuprofeni

Fish oil may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Minor Likelihood Possible Chromium + Acetaminophen, Ibuprofeni

NSAIDs might increase chromium levels in the body.

Read the full interaction Minor Likelihood Unlikely Magnesium + Acetaminophen, Ibuprofeni

Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.

Read the full interaction Moderate Likelihood Possible Alfalfa + Acetaminophen, Ibuprofeni

Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.

Read the full interaction Moderate Likelihood Possible Bromelain + Acetaminophen, Ibuprofeni

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Acetaminophen, Ibuprofen

All 1,452 ingredients in our database, ranked by severity — 342 with a Acetaminophen, Ibuprofen interaction on file and 1,110 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Acetaminophen, Ibuprofen?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Alpha-lipoic Acid with Acetaminophen, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplate...

Full Alpha-lipoic Acid + Acetaminophen, Ibuprofen answer

Can you take Fish Oil with Acetaminophen, Ibuprofen?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Fish oil may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Fish Oil + Acetaminophen, Ibuprofen answer

Can you take Chromium with Acetaminophen, Ibuprofen?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. NSAIDs might increase chromium levels in the body.

Full Chromium + Acetaminophen, Ibuprofen answer

Can you take Magnesium with Acetaminophen, Ibuprofen?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.

Full Magnesium + Acetaminophen, Ibuprofen answer

Can you take Alfalfa with Acetaminophen, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.

Full Alfalfa + Acetaminophen, Ibuprofen answer

Can you take Ketogenic Diet with Acetaminophen, Ibuprofen?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Although there is some concern that the ketogenic diet might have additive effects when used with anticoagulant and antiplatelet drugs, most...

Full Ketogenic Diet + Acetaminophen, Ibuprofen answer

Can you take Mommy's Bliss Gripe Water with Acetaminophen, Ibuprofen?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Mommy's Bliss Gripe Water contains fennel seed and ginger.

Full Mommy's Bliss Gripe Water + Acetaminophen, Ibuprofen answer

Can you take Mullein with Acetaminophen, Ibuprofen?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, a...

Full Mullein + Acetaminophen, Ibuprofen answer

Can you take Pomegranate with Acetaminophen, Ibuprofen?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, pomegranate might increase levels of drugs metabolized by CYP2C9.

Full Pomegranate + Acetaminophen, Ibuprofen answer

Can you take Red Clover with Acetaminophen, Ibuprofen?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.

Full Red Clover + Acetaminophen, Ibuprofen answer

Can you take Soy with Acetaminophen, Ibuprofen?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Soy might modestly induce CYP2C9 enzymes.

Full Soy + Acetaminophen, Ibuprofen answer

Can you take Tocotrienols with Acetaminophen, Ibuprofen?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Concomitant use of tocotrienols with anticoagulant or antiplatelet agents might increase the risk of bleeding.

Full Tocotrienols + Acetaminophen, Ibuprofen answer

Can you take Turpentine Oil with Acetaminophen, Ibuprofen?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. There is some concern that turpentine oil can inhibit CYP1A2 enzyme activity by up to 90% via induction of inflammation and subsequent downr...

Full Turpentine Oil + Acetaminophen, Ibuprofen answer

Can you take Umckaloabo with Acetaminophen, Ibuprofen?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Pelargonium sidoides might increase the risk of bleeding when taken with anticoagulant and antiplatelet drugs.

Full Umckaloabo + Acetaminophen, Ibuprofen answer

Can you take Siberian Cocklebur with Acetaminophen, Ibuprofen?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Siberian cocklebur can adversely affect the kidney.

Full Siberian Cocklebur + Acetaminophen, Ibuprofen answer

Can you take Activated Charcoal with Acetaminophen, Ibuprofen?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Acetaminophen, Ibuprofen answer

Can you take Beer with Acetaminophen, Ibuprofen?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may increase the risk of gastrointestinal (GI) bleeding.

Full Beer + Acetaminophen, Ibuprofen answer

Can you take Danshen with Acetaminophen, Ibuprofen?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Danshen + Acetaminophen, Ibuprofen answer

Can you take Piracetam with Acetaminophen, Ibuprofen?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use of piracetam and anticoagulant/antiplatelet drugs might increase the risk of bleeding.

Full Piracetam + Acetaminophen, Ibuprofen answer

Can you take Wine with Acetaminophen, Ibuprofen?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may increase the risk of gastrointestinal (GI) bleeding.

Full Wine + Acetaminophen, Ibuprofen answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Acetaminophen, Ibuprofen is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Acetaminophen, Ibuprofen, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Acetaminophen, Ibuprofen sits in 15 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Acetaminophen, Ibuprofen through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Acetaminophen, Ibuprofen through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Acetaminophen, Ibuprofen through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Acetaminophen, Ibuprofen through this category.

Cytochrome P450 2E1 (Cyp2E1) Substrates 24 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

24 of the supplement ingredients on this page reach Acetaminophen, Ibuprofen through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Acetaminophen, Ibuprofen through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Acetaminophen, Ibuprofen through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Acetaminophen, Ibuprofen through this category.

Acetaminophen (Tylenol, Others) 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Acetaminophen, Ibuprofen through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Acetaminophen, Ibuprofen through this category.

Nonsteroidal Anti-Inflammatory Drugs (Nsaids) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Acetaminophen, Ibuprofen through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Acetaminophen, Ibuprofen through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Acetaminophen, Ibuprofen through this category.

Ibuprofen (Advil, Others) 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Acetaminophen, Ibuprofen through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Acetaminophen, Ibuprofen through this category.

Related: does Acetaminophen, Ibuprofen deplete any nutrients?

Acetaminophen, Ibuprofen has 2 reported nutrient associations in the research literature — see the Acetaminophen, Ibuprofen nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Acetaminophen, Ibuprofen

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Acetaminophen, Ibuprofen.

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Pharmacist Counseling Corner

Acetaminophen, Ibuprofen & Supplements: Common Questions

What supplements interact with Acetaminophen, Ibuprofen?
Our database currently documents 342 ingredients with a known Acetaminophen, Ibuprofen interaction (7 major, 290 moderate, 45 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 342. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Beer.
Which Acetaminophen, Ibuprofen supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur, Activated Charcoal, Beer, Danshen and Piracetam, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Acetaminophen, Ibuprofen?
Plenty of supplements coexist fine with Acetaminophen, Ibuprofen; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Combogesic have the same supplement interactions as Acetaminophen, Ibuprofen?
Yes — Combogesic all contain Acetaminophen, Ibuprofen, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Acetaminophen, Ibuprofen deplete any vitamins or nutrients?
It might — Acetaminophen, Ibuprofen has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Acetaminophen, Ibuprofen nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Acetaminophen, Ibuprofen and my other medications?
This page covers Acetaminophen, Ibuprofen against supplements and herbal ingredients. Checking Acetaminophen, Ibuprofen against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 27, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.