Herb & supplement monograph

Mommy's Bliss Gripe Water Drug Interactions, Uses, Safety & More

Medically reviewed by ·Updated June 2026
What is this page for?

First and foremost: how Mommy's Bliss Gripe Water interacts with medications. The heart of this page is the interaction list — every drug Mommy's Bliss Gripe Water is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Mommy's Bliss Gripe Water is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Mommy's Bliss Gripe Water Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Mommy's Bliss Gripe Water drug interaction appears low for most people. Every listed interaction is rated minor, none is rated major or moderate, and all are graded unlikely to actually occur in people.

Interactions deserving the most attention

Nothing on this profile stands out as a strong, well-documented concern, but a few combinations deserve a mention. The fennel and ginger in gripe water could in theory add to the effects of anticoagulant and antiplatelet drugs or lower blood sugar with diabetes medications, though human evidence for either is weak and the amounts in this product are small. Animal research also suggests fennel could reduce absorption of the antibiotic ciprofloxacin, but this has not been shown in people at the low dose gripe water provides.

What the rest of the list means

A long list of interacting medications sounds worrying, but most of these entries are theoretical. Many come from lab or animal studies of how fennel might affect an enzyme the body uses to clear certain medications, and these predicted effects have not been confirmed in humans. Given the very small amounts of fennel and ginger in gripe water, meaningful changes in how medicines work are unlikely.

Check your medications against Mommy's Bliss Gripe Water

Based on HelloPharmacist’s Mommy's Bliss Gripe Water interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Mommy's Bliss Gripe Water

812 medications have a known interaction with Mommy's Bliss Gripe Water, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
Ado-trastuzumab EmtansineKadcyla
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Mommy's Bliss Gripe Water contains fennel seed.

Read the full Mommy's Bliss Gripe Water + Ado-trastuzumab Emtansine interaction Ado-trastuzumab Emtansine drug page: uses, dosage & side effects
AbciximabReoPro
Minor Anticoagulant/antiplatelet Drugs

Mommy's Bliss Gripe Water contains fennel seed and ginger.

Read the full Mommy's Bliss Gripe Water + Abciximab interaction
AbemaciclibVerzenio
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Mommy's Bliss Gripe Water contains fennel seed.

Read the full Mommy's Bliss Gripe Water + Abemaciclib interaction Abemaciclib drug page: uses, dosage & side effects
Abiraterone
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Mommy's Bliss Gripe Water contains fennel seed.

Read the full Mommy's Bliss Gripe Water + Abiraterone interaction Abiraterone drug page: uses, dosage & side effects
Abiraterone AcetateYonsa, Zytiga
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Mommy's Bliss Gripe Water contains fennel seed.

Read the full Mommy's Bliss Gripe Water + Abiraterone Acetate interaction Abiraterone Acetate drug page: uses, dosage & side effects
AbrocitinibCibinqo
Minor Anticoagulant/antiplatelet Drugs

Mommy's Bliss Gripe Water contains fennel seed and ginger.

Read the full Mommy's Bliss Gripe Water + Abrocitinib interaction Abrocitinib drug page: uses, dosage & side effects
AcalabrutinibCalquence
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Mommy's Bliss Gripe Water contains fennel seed.

Read the full Mommy's Bliss Gripe Water + Acalabrutinib interaction Acalabrutinib drug page: uses, dosage & side effects
AcarboseGlucobay, Prandase, Precose
Minor Antidiabetes Drugs

Mommy's Bliss Gripe Water contains ginger.

Read the full Mommy's Bliss Gripe Water + Acarbose interaction Acarbose drug page: uses, dosage & side effects
AcenocoumarolSintrom
Minor Anticoagulant/antiplatelet Drugs

Mommy's Bliss Gripe Water contains fennel seed and ginger.

Read the full Mommy's Bliss Gripe Water + Acenocoumarol interaction
Acetaminophen, AspirinGemnisyn
Minor Anticoagulant/antiplatelet Drugs

Mommy's Bliss Gripe Water contains fennel seed and ginger.

Read the full Mommy's Bliss Gripe Water + Acetaminophen, Aspirin interaction
Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
Minor Anticoagulant/antiplatelet Drugs

Mommy's Bliss Gripe Water contains fennel seed and ginger.

Read the full Mommy's Bliss Gripe Water + Acetaminophen, Aspirin, Caffeine interaction
Acetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Mommy's Bliss Gripe Water contains fennel seed.

Read the full Mommy's Bliss Gripe Water + Acetaminophen, Butalbital, Caffeine interaction Acetaminophen, Butalbital, Caffeine drug page: uses, dosage & side effects
Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Mommy's Bliss Gripe Water contains fennel seed.

Read the full Mommy's Bliss Gripe Water + Acetaminophen, Butalbital, Caffeine, Codeine interaction
Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Mommy's Bliss Gripe Water contains fennel seed.

Read the full Mommy's Bliss Gripe Water + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interaction
Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Mommy's Bliss Gripe Water contains fennel seed.

Read the full Mommy's Bliss Gripe Water + Acetaminophen, Caffeine, Codeine interaction
Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Mommy's Bliss Gripe Water contains fennel seed.

Read the full Mommy's Bliss Gripe Water + Acetaminophen, Caffeine, Codeine, Salicylamide interaction
Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Mommy's Bliss Gripe Water contains fennel seed.

Read the full Mommy's Bliss Gripe Water + Acetaminophen, Caffeine, Dihydrocodeine interaction
Acetaminophen, Caffeine, IsomethepteneMigralam
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Mommy's Bliss Gripe Water contains fennel seed.

Read the full Mommy's Bliss Gripe Water + Acetaminophen, Caffeine, Isometheptene interaction
Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Mommy's Bliss Gripe Water contains fennel seed.

Read the full Mommy's Bliss Gripe Water + Acetaminophen, Caffeine, Pyrilamine interaction
Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Mommy's Bliss Gripe Water contains fennel seed.

Read the full Mommy's Bliss Gripe Water + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interaction
Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Mommy's Bliss Gripe Water contains fennel seed.

Read the full Mommy's Bliss Gripe Water + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Mommy's Bliss Gripe Water contains fennel seed.

Read the full Mommy's Bliss Gripe Water + Acetaminophen, Chlorpheniramine, Dextromethorphan interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Mommy's Bliss Gripe Water contains fennel seed.

Read the full Mommy's Bliss Gripe Water + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Mommy's Bliss Gripe Water contains fennel seed.

Read the full Mommy's Bliss Gripe Water + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Mommy's Bliss Gripe Water contains fennel seed.

Read the full Mommy's Bliss Gripe Water + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interaction
Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Mommy's Bliss Gripe Water contains fennel seed.

Read the full Mommy's Bliss Gripe Water + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interaction
Acetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Mommy's Bliss Gripe Water contains fennel seed.

Read the full Mommy's Bliss Gripe Water + Acetaminophen, Chlorpheniramine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Mommy's Bliss Gripe Water contains fennel seed.

Read the full Mommy's Bliss Gripe Water + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interaction
Acetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Mommy's Bliss Gripe Water contains fennel seed.

Read the full Mommy's Bliss Gripe Water + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Mommy's Bliss Gripe Water contains fennel seed.

Read the full Mommy's Bliss Gripe Water + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interaction
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Mommy's Bliss Gripe Water combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Mommy's Bliss Gripe Water affects

Every type of medication (drug category) Mommy's Bliss Gripe Water is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 4 drug categories Mommy's Bliss Gripe Water interacts with
Anticoagulant/antiplatelet DrugsAntidiabetes DrugsCiprofloxacin (cipro)Cytochrome P450 3a4 (cyp3a4) Substrates
Anticoagulant/Antiplatelet Drugs

Mommy's Bliss Gripe Water contains fennel seed and ginger. Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs as animal research suggests that fennel oil has antithrombotic and antiplatelet effects. Ginger is also thought to have mild blood-thinning effects but this has not been demonstrated conclusively in humans, with mixed results from clinical trials. It is important to note that Mommy's Bliss Gripe Water contains only very small quantities of fennel seed and ginger, and clinically significant interactions with blood-thinning drugs are thought to be quite low.

Likelihood Unlikely Evidence C
Antidiabetes Drugs

Mommy's Bliss Gripe Water contains ginger. Theoretically, taking ginger with antidiabetes drugs might increase the risk of hypoglycemia (i.e., low blood sugar) as some studies suggest that ginger might increase insulin levels and/or decrease blood glucose levels. Based on the low amount of ginger contained in Mommy's Bliss Gripe Water, it is quite unlikely that it would cause significant changes to blood sugar, but it important to be aware of if your infant is diabetic.

Likelihood Unlikely Evidence D
Ciprofloxacin (Cipro)

Mommy's Bliss Gripe Water contains fennel seed. Theoretically, fennel might decrease the levels and clinical effects of ciprofloxacin as animal research shows that fennel reduces ciprofloxacin bioavailability by nearly 50%, possibly due to the metal cations such as calcium, iron, and magnesium contained in fennel. However, it is important to note that Mommy's Bliss Gripe Water contains a relatively small amount of fennel and it is very unlikely that it would interact with Cipro in a clinically significant way.

Likelihood Unlikely Evidence C
Cytochrome P450 3A4 (Cyp3A4) Substrates

Mommy's Bliss Gripe Water contains fennel seed. Theoretically, fennel might increase levels of drugs metabolized by CYP3A4. However, this has only been seen in vitro (i.e., in a lab setting) and has not been reported in humans. Additionally, the amount of fennel seed contained in Mommy's Bliss Gripe water is very low, and clinically significant interactions here are thought to be unlikely.

Likelihood Unlikely Evidence C
Monograph

Mommy's Bliss Gripe Water: Uses, Safety & Side Effects

Medically reviewed by · Reviewed June 2026 ·
The bottom line

Mommy's Bliss Gripe Water is a sugar-free, alcohol-free liquid made with fennel and ginger that parents use to soothe gassy, colicky, or fussy babies. Strong scientific proof that it works is limited, and most relief reported is anecdotal. Always talk to your pediatrician before giving any supplement to an infant.

Mommy's Bliss Gripe Water
Part used
Fennel seed and ginger root extracts (in water)
Common forms
Liquid drops/oral suspension
People commonly use it for
  • Infant colic
  • Gas and bloating
  • Hiccups
  • Fussiness after feeding
  • General tummy discomfort

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally considered low-risk for infants, but evidence is limited and use should be discussed with a pediatrician.

PregnancyBest avoided

This product is made for infants, not adults, so it is not intended for use during pregnancy.

BreastfeedingBest avoided

It is given directly to the baby, not taken by a breastfeeding parent.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Mommy's Bliss Gripe Water is an over-the-counter liquid supplement that parents give to babies to help calm colic, gas, and general tummy upset. The term gripe water has been used since the 1800s for liquid remedies made to ease infant fussiness and digestive discomfort.

There is no single standard recipe for gripe water. Different brands include different herbs, such as fennel, ginger, chamomile, dill, or licorice. Older formulas sometimes contained alcohol or sugar. Mommy's Bliss Gripe Water uses fennel seed and ginger in a water base, and the maker states it does not contain alcohol or added sugar.

It is usually given by dropper or small dose directly into the baby's mouth, often around feeding times when fussiness tends to occur.

Uses & effectiveness

Parents most often use gripe water for colic (long bouts of crying in an otherwise healthy baby), gas, hiccups, and general fussiness after feeding.

The honest answer is that scientific evidence is limited and weak. There are very few high-quality clinical studies on gripe water in infants, and the products tested are not all the same. Much of the benefit people report may come from the soothing act of giving the baby a small drink of liquid, the natural ups and downs of colic, or a placebo-like effect on stressed parents.

Because colic usually improves on its own with time, it is hard to know whether gripe water itself is doing anything. It should not be treated as a proven medical treatment for colic.

How it works

The proposed idea is that herbs like fennel and ginger may relax the digestive tract and help move trapped gas, which could ease cramping and bloating. Fennel has traditionally been used as a carminative (a gas-relieving herb), and ginger is long used for nausea and stomach upset.

Most of this support comes from traditional use and laboratory or animal research rather than strong studies in human infants. The amounts of active plant compounds in a typical dose are small, so any direct effect on a baby's gut is uncertain.

Safety & precautions

Mommy's Bliss Gripe Water is generally considered low-risk for infants, especially because it is free of alcohol and added sugar. Still, you should talk to your pediatrician before giving it to your baby, particularly for newborns or babies with health conditions.

Do not use gripe water as a substitute for medical care. Crying that is constant, or that comes with fever, vomiting, poor feeding, blood in the stool, or trouble breathing, needs a doctor's evaluation right away—these are not normal colic.

Check the label for the recommended minimum age, follow dosing exactly, and keep the bottle clean and tightly closed. This product is intended only for babies and is not meant for use during pregnancy or by breastfeeding parents, since it is given to the infant directly.

Side effects

When used as directed, gripe water is usually well tolerated. Possible problems include allergic reactions to the herbal ingredients, which could show up as a rash, swelling, vomiting, or trouble breathing. Seek emergency care if you notice signs of a serious allergic reaction.

Giving too much liquid to a very young baby could fill them up and affect normal feeding. Some babies may simply spit it out or seem unaffected. Stop use and call your doctor if your baby seems worse or has any unusual symptoms.

Dosing

There is no official, standardized medical dose for gripe water. Follow the directions printed on the Mommy's Bliss label, including the recommended age and the amount per dose.

Do not exceed the labeled maximum number of doses in a day. If you are unsure whether it is right for your baby, or how much to give, ask your pediatrician or pharmacist before starting.

References & further reading

The 2 sources that drive our Mommy's Bliss Gripe Water monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing.

  1. Fennel — NIH NCCIH (LiverTox / herbs information) Source
  2. Ginger — NIH NCCIH Source
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Pharmacist Counseling Corner

Mommy's Bliss Gripe Water: Common Questions

Does Mommy's Bliss Gripe Water interact with prescription medications?
Yes. We list 812 medications with a known interaction with Mommy's Bliss Gripe Water. Use the checker above to see how Mommy's Bliss Gripe Water interacts with a specific drug.
How are Mommy's Bliss Gripe Water interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Mommy's Bliss Gripe Water with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Mommy's Bliss Gripe Water interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Mommy's Bliss Gripe Water used for?
Parents use it to help soothe colic, gas, hiccups, and general tummy fussiness in babies. It is a traditional remedy, but strong proof that it works is limited.
Is Mommy's Bliss Gripe Water safe for newborns?
It is generally considered low-risk and is free of alcohol and added sugar, but you should check the label's minimum age and talk to your pediatrician before giving it to a very young or newborn baby.
Does it contain alcohol or sugar?
According to the manufacturer, Mommy's Bliss Gripe Water does not contain alcohol or added sugar. Always read the current label to confirm the ingredients.
When should I call a doctor instead of using gripe water?
Call your doctor right away if your baby has a fever, vomiting, poor feeding, blood in the stool, trouble breathing, or constant crying that won't settle—these are not normal colic and need evaluation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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