Progestin-Only (drospirenone) Oral Contraceptives

Generic name: Pronounced as droe spye' re none
Brand names
  • Slynd®
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 03/15/2021

Progestin-only (drospirenone) oral contraceptives are used to prevent pregnancy. Progestin is a female hormone. It works by preventing the release of eggs from the ovaries (ovulation) and changing the cervical mucus and the lining of the uterus. Progestin-only oral contraceptives are a very effective method of birth control, but they do not prevent the spread of of human immunodeficiency virus (HIV, the virus that causes acquired immunodeficiency syndrome [AIDS]) and other sexually transmitted diseases.

Progestin-only (drospirenone) oral contraceptives come as tablets to take by mouth once a day. Take oral contraceptives at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take your oral contraceptive exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Progestin-only (drospirenone) oral contraceptives come in packs of 28 tablets that have 2 different colors. Take 1 tablet daily for 28 days in a row in the order specified in your packet. The first 24 tablets are white and contain the active ingredient (drospirenone). The last 4 tablets are green and contain an inactive ingredient. Start a new packet the day after you take your 28th tablet.

Your doctor will tell you when you should start taking your progestin-only (drospirenone) oral contraceptive. Tell your doctor if you are switching from another type of contraception (other birth control pills, vaginal ring, transdermal patch, implant, injection, intrauterine device [IUD]).

If you vomit or have diarrhea within 3 or 4 hours after taking a white tablet (containing the active ingredient), take the next tablet in your packet as soon as possible (preferably within 12 hours of the dose previously taken). Continue your regular dosing schedule and finish your current packet. When you start a new packet, it will be one day earlier than your previous schedule. You may need to use a backup method of birth control if you vomit or have diarrhea for more than 1 day while you are taking the white tablets (containing the active ingredient). Talk to your doctor about this before you begin to take your oral contraceptive so that you can prepare a backup method of birth control in case it is needed. If you vomit or have diarrhea while you are taking an oral contraceptive, call your doctor to find out how long you should use the backup method.

Oral contraceptives will work only as long as they are taken regularly. Continue to take oral contraceptives every day even if you are spotting or bleeding, have an upset stomach, or do not think that you are likely to become pregnant. Do not stop taking oral contraceptives without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking progestin-only (drospirenone) oral contraceptive tablets,

  • tell your doctor and pharmacist if you are allergic to drospirenone, other progestins, or any other medications.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking. Be sure to mention any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril, enalapril (Epaned, Vasotec, in Vaseretic), fosinopril, lisinopril (in Zestoretic), moexipril, perindopril (in Prestalia), quinapril (Accupril, in Accuretic, in Quinaretic), ramipril (Altace) and trandolapril (in Tarka); angiotensin receptor blockers such as azilsartan (Edarbi, in Edarbyclor), candesartan (Atacand, in Atacand HCT), eprosartan, irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar HCT, in Tribenzor), telmisartan (Micardis, in Micardis HCT, in Twynsta) and valsartan (Diovan, in Entresto, in Diovan HCT, in Exforge, in Exforge HCT); antifungal medications such as itraconazole (Onmel, Sporanox), ketoconazole, and voriconazole (Vfend); aprepitant (Emend); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); bosentan (Tracleer); boceprevir (Victrelis); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, others); clarithromycin; certain medications for HIV including efavirenz (Sustiva, in Atripla, in Symfi) and indinavir (Crixivan); diuretics ('water pills') such as amiloride (Midamor), spironolactone (Aldactone, Carospir, in Aldactzide), and triamterene (Dyrenium, in Dyazide, in Maxzide); eplerenone (Inspra); felbamate (Felbatol); griseofulvin (Gris-Peg); heparin; phenobarbital; phenytoin (Dilantin, Phenytek); potassium supplements; oxcarbazepine (Trileptal); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); and rufinamide (Banzel). Your doctor may need to change the doses of your medications or monitor you carefully for side effects

  • tell your doctor what herbal products you are taking, especially St. John's wort.

  • tell your doctor if you have adrenal insufficiency (condition in which the body does not produce enough of certain natural substances needed for important functions such as blood pressure); unexplained abnormal vaginal bleeding; liver cancer, liver tumors, or other types of liver disease; or kidney disease. Also tell your doctor if you have or have ever had breast cancer or cancer of the lining of the uterus, cervix, or vagina. Your doctor will probably tell you not to take progestin-only (drospirenone) oral contraceptives.

  • tell your doctor if you have or have ever had blood clots in your legs, lungs, or eyes; stroke or mini-stroke; a heart attack; osteoporosis; diabetes; high levels of potassium in the blood; or depression.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking progestin-only (drospirenone) oral contraceptives, call your doctor.

  • if you miss periods while you are taking oral contraceptives, you may be pregnant. If you have taken your tablets according to the directions and you miss one period, you may continue to take your tablets. However, if you have not taken your tablets as directed and you miss one period or if you have taken your tablets as directed and you miss two periods, call your doctor and use another method of birth control until you have a pregnancy test. Also, call your doctor if you experience symptoms of pregnancy such as nausea, vomiting, and breast tenderness, or if you suspect you may be pregnant.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking progestin-only (drospirenone) oral contraceptives.

Unless your doctor tells you otherwise, continue your normal diet.

If you miss 2 or more doses of the white tablets (containing the active ingredient), you may not be protected from pregnancy. You may need to use a backup method of birth control for 7 days. If you miss doses of the green tablets (containing inactive ingredients), skip the missed dose and continue your regular dosing schedule. Progestin-only (drospirenone) oral contraceptive tablets come with specific directions to follow if you miss one or more doses. Carefully read the directions in the manufacturer's information for the patient that came with your oral contraceptive. If you have any questions, call your doctor or pharmacist. Continue to take your tablets as scheduled and use a backup method of birth control until your questions are answered.

  • Progestin-only (drospirenone) oral contraceptive may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • vomiting

    • acne

    • irregular menstrual periods

    • bleeding or spotting between menstrual periods

    • painful periods

    • headache

    • breast tenderness

    • weight gain

    • decreased sexual desire

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

    • severe headache

    • severe vomiting

    • speech problems

    • weakness or numbness of an arm or leg

    • chest pain or chest heaviness

    • irregular or rapid heartbeat

    • shortness of breath

    • leg pain

    • partial or complete loss of vision or vision changes

    • severe stomach pain

    • yellowing of the skin or eyes

    • pain in the upper right part of the stomach

    • depression, especially if you also have trouble sleeping, tiredness, loss of energy, other mood changes, or if you are thinking of harming yourself

    • menstrual bleeding that is unusually heavy or that lasts a long time

    • lack of menstrual periods

  • Oral contraceptives may increase the risk of getting cervical cancer and liver tumors. It is not known whether progestin-only (drospirenone) oral contraceptives also increase the risks of these conditions. Talk to your doctor about the risks of taking this medication.

  • Progestin-only (drospirenone) oral contraceptive may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the packet it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

  • nausea

  • vomiting

  • vaginal bleeding

Keep all appointments with your doctor.

Before you have any laboratory tests, tell the laboratory personnel that you take progestin-only (drospirenone) oral contraceptive, as this medication may interfere with some laboratory tests.

If you want to become pregnant, stop taking progestin-only (drospirenone) contraceptive. Progestin-only contraceptives should not delay your ability to get pregnant.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

  • Birth-control pills
  • POP

Drug Interaction
Repaglinide Repaglinide The therapeutic efficacy of Repaglinide can be decreased when used in combination with Drospirenone.
Insulin Glargine (rDNA origin) Injection Insulin Glargine (rDNA origin) Injection The therapeutic efficacy of Insulin glargine can be decreased when used in combination with Drospirenone.
Delavirdine Delavirdine The metabolism of Drospirenone can be decreased when combined with Delavirdine.
Acitretin Acitretin The therapeutic efficacy of Drospirenone can be decreased when used in combination with Acitretin.
Alitretinoin Alitretinoin The therapeutic efficacy of Drospirenone can be decreased when used in combination with Alitretinoin.
Aminophylline Aminophylline The metabolism of Aminophylline can be decreased when combined with Drospirenone.
Bisacodyl Bisacodyl The risk or severity of adverse effects can be increased when Drospirenone is combined with Bisacodyl.
Candesartan Candesartan The risk or severity of hyperkalemia can be increased when Candesartan is combined with Drospirenone.
Cilostazol Cilostazol Drospirenone may increase the excretion rate of Cilostazol which could result in a lower serum level and potentially a reduction in efficacy.
Diphenoxylate Diphenoxylate The therapeutic efficacy of Drospirenone can be decreased when used in combination with Diphenoxylate.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Erythromycin can be decreased when combined with Drospirenone.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Drospirenone may increase the excretion rate of Conjugated estrogens which could result in a lower serum level and potentially a reduction in efficacy.
Fenofibrate Fenofibrate The metabolism of Drospirenone can be decreased when combined with Fenofibrate.
Guanfacine Guanfacine Drospirenone may increase the excretion rate of Guanfacine which could result in a lower serum level and potentially a reduction in efficacy.
Magnesium Hydroxide Magnesium Hydroxide The risk or severity of adverse effects can be increased when Drospirenone is combined with Magnesium hydroxide.
Magnesium Oxide Magnesium Oxide The risk or severity of adverse effects can be increased when Drospirenone is combined with Magnesium oxide.
Methylergonovine Methylergonovine The metabolism of Drospirenone can be decreased when combined with Methylergometrine.
Miglitol Miglitol The therapeutic efficacy of Miglitol can be decreased when used in combination with Drospirenone.
Mycophenolate Mycophenolate The serum concentration of Drospirenone can be decreased when it is combined with Mycophenolic acid.
Olsalazine Olsalazine The risk or severity of hyperkalemia can be increased when Olsalazine is combined with Drospirenone.
Paregoric Paregoric The therapeutic efficacy of Drospirenone can be decreased when used in combination with Morphine.
Penbutolol Penbutolol The risk or severity of hyperkalemia can be increased when Acebutolol is combined with Drospirenone.
Pentazocine Pentazocine The therapeutic efficacy of Drospirenone can be decreased when used in combination with Pentazocine.
Polyethylene glycol-electrolyte solution (PEG-ES) Polyethylene glycol-electrolyte solution (PEG-ES) The risk or severity of adverse effects can be increased when Drospirenone is combined with Polyethylene glycol.
Potassium Potassium Potassium cation may increase the excretion rate of Drospirenone which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone The serum concentration of Drospirenone can be increased when it is combined with Prednisone.
Psyllium Psyllium The risk or severity of adverse effects can be increased when Drospirenone is combined with Plantago seed.
Ranitidine Ranitidine Ranitidine may increase the excretion rate of Drospirenone which could result in a lower serum level and potentially a reduction in efficacy.
Reserpine Reserpine Drospirenone may increase the excretion rate of Reserpine which could result in a lower serum level and potentially a reduction in efficacy.
Rizatriptan Rizatriptan Drospirenone may increase the excretion rate of Rizatriptan which could result in a lower serum level and potentially a reduction in efficacy.
Sumatriptan Sumatriptan Drospirenone may increase the excretion rate of Sumatriptan which could result in a lower serum level and potentially a reduction in efficacy.
Tacrolimus Tacrolimus The metabolism of Tacrolimus can be decreased when combined with Drospirenone.
Tizanidine Tizanidine The metabolism of Drospirenone can be increased when combined with Tizanidine.
Triamcinolone Triamcinolone The serum concentration of Drospirenone can be increased when it is combined with Triamcinolone.
Ampicillin Injection Ampicillin Injection Ampicillin may increase the excretion rate of Drospirenone which could result in a lower serum level and potentially a reduction in efficacy.
Doxycycline Injection Doxycycline Injection The serum concentration of Drospirenone can be decreased when it is combined with Doxycycline.
Fluconazole Injection Fluconazole Injection The bioavailability of Drospirenone can be increased when combined with Fluconazole.
Hydromorphone Injection Hydromorphone Injection The therapeutic efficacy of Drospirenone can be decreased when used in combination with Hydromorphone.
Levofloxacin Injection Levofloxacin Injection Drospirenone may increase the excretion rate of Levofloxacin which could result in a lower serum level and potentially a reduction in efficacy.
Meperidine Injection Meperidine Injection Drospirenone may increase the excretion rate of Meperidine which could result in a lower serum level and potentially a reduction in efficacy.
Methylprednisolone Injection Methylprednisolone Injection The serum concentration of Drospirenone can be increased when it is combined with Methylprednisolone.
Metoclopramide Injection Metoclopramide Injection Drospirenone may increase the excretion rate of Metoclopramide which could result in a lower serum level and potentially a reduction in efficacy.
Metronidazole Injection Metronidazole Injection The metabolism of Drospirenone can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The therapeutic efficacy of Drospirenone can be decreased when used in combination with Morphine.
Vancomycin Injection Vancomycin Injection Drospirenone may increase the excretion rate of Vancomycin which could result in a lower serum level and potentially a reduction in efficacy.
Altretamine Altretamine Drospirenone may increase the excretion rate of Amphetamine which could result in a lower serum level and potentially a reduction in efficacy.
Cyclosporine Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Drospirenone.
Enoxaparin Injection Enoxaparin Injection Drospirenone may decrease the anticoagulant activities of Enoxaparin.
Dofetilide Dofetilide The metabolism of Dofetilide can be decreased when combined with Drospirenone.
Eprosartan Eprosartan The risk or severity of hyperkalemia can be increased when Eprosartan is combined with Drospirenone.
Meloxicam Meloxicam The risk or severity of hyperkalemia can be increased when Meloxicam is combined with Drospirenone.
Orlistat Orlistat The metabolism of Drospirenone can be increased when combined with Orlistat.
Oxcarbazepine Oxcarbazepine The metabolism of Drospirenone can be increased when combined with Oxcarbazepine.
Pantoprazole Pantoprazole Drospirenone may increase the excretion rate of Pantoprazole which could result in a lower serum level and potentially a reduction in efficacy.
Sevelamer Sevelamer Sevelamer can cause a decrease in the absorption of Drospirenone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Telmisartan Telmisartan The risk or severity of hyperkalemia can be increased when Telmisartan is combined with Drospirenone.
Temozolomide Temozolomide Drospirenone may increase the excretion rate of Temozolomide which could result in a lower serum level and potentially a reduction in efficacy.
Zaleplon Zaleplon The metabolism of Drospirenone can be increased when combined with Zaleplon.
Anakinra Anakinra The metabolism of Drospirenone can be increased when combined with Anakinra.
Pentosan Polysulfate Pentosan Polysulfate Drospirenone may decrease the anticoagulant activities of Pentosan polysulfate.
Etanercept Injection Etanercept Injection The metabolism of Drospirenone can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Drospirenone can be increased when combined with Modafinil.
Perindopril Perindopril Perindopril may increase the hyperkalemic activities of Drospirenone.
Tenofovir Tenofovir The metabolism of Tenofovir can be decreased when combined with Drospirenone.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The risk or severity of hyperkalemia can be increased when Choline magnesium trisalicylate is combined with Drospirenone.
Sirolimus Sirolimus The metabolism of Sirolimus can be decreased when combined with Drospirenone.
Epinephrine Injection Epinephrine Injection The risk or severity of Cardiac Arrhythmia can be increased when Epinephrine is combined with Drospirenone.
Eplerenone Eplerenone The risk or severity of hyperkalemia can be increased when Drospirenone is combined with Eplerenone.
Olmesartan Olmesartan The risk or severity of hyperkalemia can be increased when Olmesartan is combined with Drospirenone.
Zonisamide Zonisamide The metabolism of Drospirenone can be increased when combined with Zonisamide.
Adalimumab Injection Adalimumab Injection The metabolism of Drospirenone can be increased when combined with Adalimumab.
Atomoxetine Atomoxetine Drospirenone may increase the excretion rate of Atomoxetine which could result in a lower serum level and potentially a reduction in efficacy.
Atazanavir Atazanavir The serum concentration of Drospirenone can be increased when it is combined with Atazanavir.
Almotriptan Almotriptan Drospirenone may increase the excretion rate of Almotriptan which could result in a lower serum level and potentially a reduction in efficacy.
Mefloquine Mefloquine The metabolism of Drospirenone can be decreased when combined with Mefloquine.
Polyethylene Glycol 3350 Polyethylene Glycol 3350 The risk or severity of adverse effects can be increased when Drospirenone is combined with Polyethylene glycol.
Rosuvastatin Rosuvastatin Rosuvastatin may decrease the excretion rate of Drospirenone which could result in a higher serum level.
Aprepitant Aprepitant The metabolism of Drospirenone can be decreased when combined with Aprepitant.
Emtricitabine Emtricitabine Drospirenone may increase the excretion rate of Emtricitabine which could result in a lower serum level and potentially a reduction in efficacy.
Memantine Memantine Drospirenone may increase the excretion rate of Memantine which could result in a lower serum level and potentially a reduction in efficacy.
Tegaserod Tegaserod The risk or severity of adverse effects can be increased when Drospirenone is combined with Tegaserod.
Tadalafil Tadalafil Drospirenone may increase the excretion rate of Tadalafil which could result in a lower serum level and potentially a reduction in efficacy.
Progesterone Progesterone The metabolism of Drospirenone can be increased when combined with Progesterone.
Infliximab Injection Infliximab Injection The metabolism of Drospirenone can be increased when combined with Infliximab.
Rifaximin Rifaximin The metabolism of Drospirenone can be increased when combined with Rifaximin.
Duloxetine Duloxetine The metabolism of Drospirenone can be decreased when combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Norethisterone can be decreased when combined with Drospirenone.
Tinidazole Tinidazole Drospirenone may increase the excretion rate of Tinidazole which could result in a lower serum level and potentially a reduction in efficacy.
Bosentan Bosentan The serum concentration of Drospirenone can be decreased when it is combined with Bosentan.
Cefditoren Cefditoren Drospirenone may increase the excretion rate of Cefdinir which could result in a lower serum level and potentially a reduction in efficacy.
Cyanocobalamin Injection Cyanocobalamin Injection Drospirenone may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
Erlotinib Erlotinib The metabolism of Erlotinib can be decreased when combined with Drospirenone.
Eszopiclone Eszopiclone Drospirenone may increase the excretion rate of Eszopiclone which could result in a lower serum level and potentially a reduction in efficacy.
Ganciclovir Ganciclovir Drospirenone may increase the excretion rate of Ganciclovir which could result in a lower serum level and potentially a reduction in efficacy.
Insulin Aspart (rDNA Origin) Injection Insulin Aspart (rDNA Origin) Injection The therapeutic efficacy of Insulin aspart can be decreased when used in combination with Drospirenone.
Ribavirin Ribavirin Drospirenone may increase the excretion rate of Ribavirin which could result in a lower serum level and potentially a reduction in efficacy.
Valganciclovir Valganciclovir Drospirenone may increase the excretion rate of Valganciclovir which could result in a lower serum level and potentially a reduction in efficacy.
Voriconazole Voriconazole The metabolism of Drospirenone can be decreased when combined with Voriconazole.
Dextroamphetamine Dextroamphetamine Drospirenone may increase the excretion rate of Amphetamine which could result in a lower serum level and potentially a reduction in efficacy.
Pramlintide Injection Pramlintide Injection The therapeutic efficacy of Pramlintide can be decreased when used in combination with Drospirenone.
Exenatide Injection Exenatide Injection Exenatide can cause a decrease in the absorption of Drospirenone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ramelteon Ramelteon Drospirenone may increase the excretion rate of Ramelteon which could result in a lower serum level and potentially a reduction in efficacy.
Fentanyl Fentanyl Drospirenone may increase the excretion rate of Fentanyl which could result in a lower serum level and potentially a reduction in efficacy.
Pregabalin Pregabalin The metabolism of Drospirenone can be increased when combined with Pregabalin.
Deferasirox Deferasirox The metabolism of Drospirenone can be increased when combined with Deferasirox.
Tipranavir Tipranavir The metabolism of Tipranavir can be decreased when combined with Drospirenone.
Felbamate Felbamate The metabolism of Drospirenone can be increased when combined with Felbamate.
Insulin Detemir (rDNA Origin) Injection Insulin Detemir (rDNA Origin) Injection The therapeutic efficacy of Insulin detemir can be decreased when used in combination with Drospirenone.
Ranolazine Ranolazine Ranolazine may increase the excretion rate of Drospirenone which could result in a lower serum level and potentially a reduction in efficacy.
Abatacept Injection Abatacept Injection The metabolism of Drospirenone can be increased when combined with Abatacept.
Rasagiline Rasagiline Drospirenone may increase the excretion rate of Rasagiline which could result in a lower serum level and potentially a reduction in efficacy.
Imatinib Imatinib The metabolism of Drospirenone can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Drospirenone.
Varenicline Varenicline Drospirenone may increase the excretion rate of Varenicline which could result in a lower serum level and potentially a reduction in efficacy.
Gefitinib Gefitinib The metabolism of Drospirenone can be decreased when combined with Gefitinib.
Albuterol Albuterol Drospirenone may increase the excretion rate of Salbutamol which could result in a lower serum level and potentially a reduction in efficacy.
Paliperidone Paliperidone Drospirenone may increase the excretion rate of Paliperidone which could result in a lower serum level and potentially a reduction in efficacy.
Bortezomib Bortezomib The metabolism of Bortezomib can be decreased when combined with Drospirenone.
Clofarabine Injection Clofarabine Injection Drospirenone may increase the excretion rate of Clofarabine which could result in a lower serum level and potentially a reduction in efficacy.
Insulin Glulisine (rDNA origin) Injection Insulin Glulisine (rDNA origin) Injection The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Drospirenone.
Lubiprostone Lubiprostone The risk or severity of adverse effects can be increased when Drospirenone is combined with Lubiprostone.
Posaconazole Posaconazole The metabolism of Drospirenone can be decreased when combined with Posaconazole.
Primaquine Primaquine The metabolism of Primaquine can be decreased when combined with Drospirenone.
Aliskiren Aliskiren The risk or severity of hyperkalemia can be increased when Drospirenone is combined with Aliskiren.
Darunavir Darunavir The therapeutic efficacy of Darunavir can be decreased when used in combination with Drospirenone.
Pemetrexed Injection Pemetrexed Injection Drospirenone may increase the excretion rate of Pemetrexed which could result in a lower serum level and potentially a reduction in efficacy.
Sorafenib Sorafenib The metabolism of Drospirenone can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Sunitinib can be decreased when combined with Drospirenone.
Lapatinib Lapatinib The metabolism of Drospirenone can be decreased when combined with Lapatinib.
Levocetirizine Levocetirizine Drospirenone may increase the excretion rate of Levocetirizine which could result in a lower serum level and potentially a reduction in efficacy.
Pegaptanib Injection Pegaptanib Injection Drospirenone may increase the excretion rate of Pegaptanib which could result in a lower serum level and potentially a reduction in efficacy.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Drospirenone.
Armodafinil Armodafinil The metabolism of Drospirenone can be increased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection Drospirenone may increase the excretion rate of Azacitidine which could result in a lower serum level and potentially a reduction in efficacy.
Ivermectin Ivermectin The metabolism of Drospirenone can be increased when combined with Ivermectin.
Paclitaxel (with polyoxyethylated castor oil) Injection Paclitaxel (with polyoxyethylated castor oil) Injection The risk or severity of adverse effects can be increased when Drospirenone is combined with Castor oil.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Drospirenone.
Lenalidomide Lenalidomide Drospirenone may increase the excretion rate of Lenalidomide which could result in a lower serum level and potentially a reduction in efficacy.
Nilotinib Nilotinib The metabolism of Drospirenone can be decreased when combined with Nilotinib.
Bexarotene Bexarotene The therapeutic efficacy of Drospirenone can be decreased when used in combination with Bexarotene.
Budesonide Budesonide The serum concentration of Budesonide can be increased when it is combined with Drospirenone.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Drospirenone can be decreased when combined with Chloramphenicol.
Desmopressin Desmopressin Drospirenone may increase the excretion rate of Desmopressin which could result in a lower serum level and potentially a reduction in efficacy.
Doripenem Injection Doripenem Injection Drospirenone may increase the excretion rate of Doripenem which could result in a lower serum level and potentially a reduction in efficacy.
Etravirine Etravirine The metabolism of Drospirenone can be increased when combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection Drospirenone may increase the excretion rate of Arsenic trioxide which could result in a lower serum level and potentially a reduction in efficacy.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Drospirenone can be decreased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The metabolism of Desvenlafaxine can be decreased when combined with Drospirenone.
Cevimeline Cevimeline Drospirenone may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
Nebivolol Nebivolol The risk or severity of hyperkalemia can be increased when Drospirenone is combined with Nebivolol.
Tretinoin Tretinoin The therapeutic efficacy of Drospirenone can be decreased when used in combination with Tretinoin.
Pilocarpine Pilocarpine The metabolism of Drospirenone can be decreased when combined with Pilocarpine.
Certolizumab Injection Certolizumab Injection The metabolism of Drospirenone can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Drospirenone.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Drospirenone.
Daptomycin Injection Daptomycin Injection Drospirenone may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy.
Mitotane Mitotane The metabolism of Drospirenone can be increased when combined with Mitotane.
Methylnaltrexone Injection Methylnaltrexone Injection Drospirenone may increase the excretion rate of Methylnaltrexone which could result in a lower serum level and potentially a reduction in efficacy.
Rufinamide Rufinamide The metabolism of Drospirenone can be increased when combined with Rufinamide.
Midazolam Midazolam Drospirenone may increase the excretion rate of Midazolam which could result in a lower serum level and potentially a reduction in efficacy.
Naltrexone Injection Naltrexone Injection The therapeutic efficacy of Drospirenone can be decreased when used in combination with Naltrexone.
Dexrazoxane Injection Dexrazoxane Injection Drospirenone may increase the excretion rate of Dexrazoxane which could result in a lower serum level and potentially a reduction in efficacy.
Milnacipran Milnacipran The metabolism of Milnacipran can be decreased when combined with Drospirenone.
Plerixafor Injection Plerixafor Injection Drospirenone may increase the excretion rate of Plerixafor which could result in a lower serum level and potentially a reduction in efficacy.
Sodium Phosphate Sodium Phosphate Drospirenone may increase the nephrotoxic activities of Sodium phosphate, monobasic.
Fesoterodine Fesoterodine Drospirenone may increase the excretion rate of Fesoterodine which could result in a lower serum level and potentially a reduction in efficacy.
Betaxolol Betaxolol The risk or severity of hyperkalemia can be increased when Betaxolol is combined with Drospirenone.
Prasugrel Prasugrel Drospirenone may decrease the anticoagulant activities of Prasugrel.
Lacosamide Lacosamide The metabolism of Lacosamide can be increased when combined with Drospirenone.
Everolimus Everolimus The metabolism of Everolimus can be decreased when combined with Drospirenone.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Tolvaptan can be decreased when combined with Drospirenone.
Dronedarone Dronedarone The metabolism of Dronedarone can be decreased when combined with Drospirenone.
Pralatrexate Injection Pralatrexate Injection Drospirenone may increase the excretion rate of Pralatrexate which could result in a lower serum level and potentially a reduction in efficacy.
Palonosetron Injection Palonosetron Injection Drospirenone may increase the excretion rate of Palonosetron which could result in a lower serum level and potentially a reduction in efficacy.
Saxagliptin Saxagliptin The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Drospirenone.
Telavancin Injection Telavancin Injection Drospirenone may increase the excretion rate of Telavancin which could result in a lower serum level and potentially a reduction in efficacy.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Drospirenone.
Tapentadol Tapentadol The therapeutic efficacy of Drospirenone can be decreased when used in combination with Tapentadol.
Topotecan Topotecan The metabolism of Drospirenone can be increased when combined with Topotecan.
Golimumab Injection Golimumab Injection The metabolism of Drospirenone can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Drospirenone can be decreased when combined with Pazopanib.
Vigabatrin Vigabatrin The metabolism of Drospirenone can be increased when combined with Vigabatrin.
Albendazole Albendazole The metabolism of Drospirenone can be decreased when combined with Albendazole.
Ulipristal Ulipristal The therapeutic efficacy of Drospirenone can be decreased when used in combination with Ulipristal.
Oxymorphone Oxymorphone The therapeutic efficacy of Drospirenone can be decreased when used in combination with Oxymorphone.
Dabigatran Dabigatran The therapeutic efficacy of Dabigatran can be decreased when used in combination with Drospirenone.
Liraglutide Injection Liraglutide Injection The therapeutic efficacy of Liraglutide can be decreased when used in combination with Drospirenone.
Tocilizumab Injection Tocilizumab Injection The metabolism of Drospirenone can be increased when combined with Tocilizumab.
Dalfampridine Dalfampridine Drospirenone may increase the excretion rate of Dalfampridine which could result in a lower serum level and potentially a reduction in efficacy.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Drospirenone.
Acetaminophen Injection Acetaminophen Injection The metabolism of Drospirenone can be increased when combined with Acetaminophen.
Ipilimumab Injection Ipilimumab Injection Drospirenone may increase the excretion rate of Ipilimumab which could result in a lower serum level and potentially a reduction in efficacy.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Drospirenone can be decreased when combined with Aldesleukin.
Terbutaline Injection Terbutaline Injection Drospirenone may increase the excretion rate of Terbutaline which could result in a lower serum level and potentially a reduction in efficacy.
Azilsartan Azilsartan The risk or severity of hyperkalemia can be increased when Azilsartan medoxomil is combined with Drospirenone.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be decreased when combined with Drospirenone.
Roflumilast Roflumilast The metabolism of Roflumilast can be decreased when combined with Drospirenone.
Linagliptin Linagliptin The therapeutic efficacy of Linagliptin can be decreased when used in combination with Drospirenone.
Rilpivirine Rilpivirine The metabolism of Drospirenone can be decreased when combined with Rilpivirine.
Telaprevir Telaprevir The metabolism of Drospirenone can be decreased when combined with Glecaprevir.
Potassium Iodide Potassium Iodide Potassium Iodide may increase the hyperkalemic activities of Drospirenone.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Drospirenone can be decreased when combined with Cyclophosphamide.
Rivaroxaban Rivaroxaban The therapeutic efficacy of Rivaroxaban can be decreased when used in combination with Drospirenone.
Ticagrelor Ticagrelor The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Drospirenone.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Drospirenone can be decreased when combined with Brentuximab vedotin.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Drospirenone.
Vandetanib Vandetanib The metabolism of Vandetanib can be decreased when combined with Drospirenone.
Clobazam Clobazam The serum concentration of Drospirenone can be decreased when it is combined with Clobazam.
Vemurafenib Vemurafenib The metabolism of Drospirenone can be decreased when combined with Vemurafenib.
Ivacaftor Ivacaftor The metabolism of Drospirenone can be decreased when combined with Ivacaftor.
Deferiprone Deferiprone Drospirenone may increase the excretion rate of Deferiprone which could result in a lower serum level and potentially a reduction in efficacy.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Drospirenone.
Crizotinib Crizotinib The metabolism of Crizotinib can be decreased when combined with Drospirenone.
Cabergoline Cabergoline The metabolism of Drospirenone can be decreased when combined with Cabergoline.
Tranexamic Acid Tranexamic Acid Drospirenone may increase the thrombogenic activities of Tranexamic acid.
Naloxone Injection Naloxone Injection The metabolism of Drospirenone can be decreased when combined with Naloxone.
Fondaparinux Injection Fondaparinux Injection Drospirenone may decrease the anticoagulant activities of Fondaparinux.
Ezogabine Ezogabine The metabolism of Drospirenone can be increased when combined with Tiagabine.
Iloprost Iloprost Drospirenone may decrease the anticoagulant activities of Iloprost.
Enzalutamide Enzalutamide The metabolism of Drospirenone can be increased when combined with Enzalutamide.
Mirabegron Mirabegron Drospirenone may increase the excretion rate of Mirabegron which could result in a lower serum level and potentially a reduction in efficacy.
Regorafenib Regorafenib The metabolism of Drospirenone can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Drospirenone can be decreased when combined with Bosutinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The serum concentration of Drospirenone can be increased when it is combined with Corticotropin.
Linaclotide Linaclotide The risk or severity of adverse effects can be increased when Drospirenone is combined with Linaclotide.
Lorcaserin Lorcaserin The therapeutic efficacy of Mecasermin can be decreased when used in combination with Drospirenone.
Teduglutide Injection Teduglutide Injection Drospirenone may increase the excretion rate of Teduglutide which could result in a lower serum level and potentially a reduction in efficacy.
Alogliptin Alogliptin The therapeutic efficacy of Alogliptin can be decreased when used in combination with Drospirenone.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Drospirenone.
Pomalidomide Pomalidomide The metabolism of Pomalidomide can be decreased when combined with Drospirenone.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Drospirenone can be decreased when combined with Trastuzumab emtansine.
Apixaban Apixaban Drospirenone may decrease the anticoagulant activities of Apixaban.
Canagliflozin Canagliflozin The therapeutic efficacy of Canagliflozin can be decreased when used in combination with Drospirenone.
Dabrafenib Dabrafenib The metabolism of Drospirenone can be decreased when combined with Dabrafenib.
Trametinib Trametinib The metabolism of Drospirenone can be increased when combined with Trametinib.
Levomilnacipran Levomilnacipran Drospirenone may increase the excretion rate of Levomilnacipran which could result in a lower serum level and potentially a reduction in efficacy.
Ertapenem Injection Ertapenem Injection Drospirenone may increase the excretion rate of Ertapenem which could result in a lower serum level and potentially a reduction in efficacy.
Tigecycline Injection Tigecycline Injection The serum concentration of Drospirenone can be decreased when it is combined with Tigecycline.
Vortioxetine Vortioxetine Drospirenone may increase the excretion rate of Vortioxetine which could result in a lower serum level and potentially a reduction in efficacy.
Perampanel Perampanel The metabolism of Perampanel can be increased when combined with Drospirenone.
Lomitapide Lomitapide The metabolism of Drospirenone can be decreased when combined with Lomitapide.
Ketorolac Injection Ketorolac Injection The risk or severity of hyperkalemia can be increased when Ketorolac is combined with Drospirenone.
Simeprevir Simeprevir The metabolism of Simeprevir can be decreased when combined with Drospirenone.
Sofosbuvir Sofosbuvir Drospirenone may increase the excretion rate of Sofosbuvir which could result in a lower serum level and potentially a reduction in efficacy.
Dapagliflozin Dapagliflozin The therapeutic efficacy of Dapagliflozin can be decreased when used in combination with Drospirenone.
Apremilast Apremilast The metabolism of Drospirenone can be increased when combined with Apremilast.
Droxidopa Droxidopa The risk or severity of Cardiac Arrhythmia can be increased when Droxidopa is combined with Drospirenone.
Ceritinib Ceritinib The metabolism of Drospirenone can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Drospirenone can be increased when combined with Siltuximab.
Albiglutide Injection Albiglutide Injection The therapeutic efficacy of Albiglutide can be decreased when used in combination with Drospirenone.
Eslicarbazepine Eslicarbazepine The metabolism of Drospirenone can be increased when combined with Eslicarbazepine.
Idelalisib Idelalisib The metabolism of Idelalisib can be decreased when combined with Drospirenone.
Testosterone Injection Testosterone Injection The metabolism of Drospirenone can be increased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Drospirenone can be increased when combined with Oritavancin.
Empagliflozin Empagliflozin Drospirenone may increase the diuretic activities of Empagliflozin.
Vorapaxar Vorapaxar Drospirenone may decrease the anticoagulant activities of Vorapaxar.
Hydrocodone Hydrocodone The therapeutic efficacy of Hydrocodone can be decreased when used in combination with Drospirenone.
Suvorexant Suvorexant The metabolism of Suvorexant can be decreased when combined with Drospirenone.
Dulaglutide Injection Dulaglutide Injection The therapeutic efficacy of Dulaglutide can be decreased when used in combination with Drospirenone.
Edoxaban Edoxaban Drospirenone may decrease the anticoagulant activities of Edoxaban.
Olaparib Olaparib The metabolism of Drospirenone can be decreased when combined with Olaparib.
Methamphetamine Methamphetamine Drospirenone may increase the excretion rate of Metamfetamine which could result in a lower serum level and potentially a reduction in efficacy.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Drospirenone.
Lanreotide Injection Lanreotide Injection The metabolism of Drospirenone can be decreased when combined with Lanreotide.
Nintedanib Nintedanib The metabolism of Nintedanib can be decreased when combined with Drospirenone.
Secukinumab Injection Secukinumab Injection The metabolism of Drospirenone can be increased when combined with Secukinumab.
Palbociclib Palbociclib The metabolism of Drospirenone can be decreased when combined with Palbociclib.
Insulin Human Inhalation Insulin Human Inhalation The therapeutic efficacy of Insulin human can be decreased when used in combination with Drospirenone.
Lenvatinib Lenvatinib The metabolism of Drospirenone can be increased when combined with Lenvatinib.
Panobinostat Panobinostat The metabolism of Panobinostat can be decreased when combined with Drospirenone.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Drospirenone.
Deoxycholic Acid Injection Deoxycholic Acid Injection The therapeutic efficacy of Deoxycholic acid can be decreased when used in combination with Drospirenone.
Amiloride Amiloride The risk or severity of hyperkalemia can be increased when Amiloride is combined with Drospirenone.
Isavuconazonium Injection Isavuconazonium Injection The metabolism of Drospirenone can be increased when combined with Isavuconazonium.
Macitentan Macitentan Drospirenone may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy.
Sonidegib Sonidegib The metabolism of Sonidegib can be decreased when combined with Drospirenone.
Flibanserin Flibanserin The risk or severity of adverse effects can be increased when Drospirenone is combined with Flibanserin.
Prednisolone Prednisolone The serum concentration of Drospirenone can be increased when it is combined with Prednisolone.
Ziprasidone Injection Ziprasidone Injection The metabolism of Ziprasidone can be decreased when combined with Drospirenone.
Penicillin G Procaine Injection Penicillin G Procaine Injection Procaine benzylpenicillin may increase the excretion rate of Drospirenone which could result in a lower serum level and potentially a reduction in efficacy.
Eluxadoline Eluxadoline The therapeutic efficacy of Drospirenone can be decreased when used in combination with Eluxadoline.
Insulin Degludec (rDNA Origin) Injection Insulin Degludec (rDNA Origin) Injection The therapeutic efficacy of Insulin degludec can be decreased when used in combination with Drospirenone.
Cobimetinib Cobimetinib The metabolism of Cobimetinib can be decreased when combined with Drospirenone.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Drospirenone.
Osimertinib Osimertinib The metabolism of Drospirenone can be decreased when combined with Osimertinib.
Alectinib Alectinib The metabolism of Alectinib can be decreased when combined with Drospirenone.
Ixazomib Ixazomib The metabolism of Ixazomib can be decreased when combined with Drospirenone.
Rifapentine Rifapentine The metabolism of Drospirenone can be increased when combined with Rifapentine.
Lesinurad Lesinurad Drospirenone may increase the excretion rate of Lesinurad which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The metabolism of Drospirenone can be decreased when combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The serum concentration of Drospirenone can be increased when it is combined with Dexamethasone.
Defibrotide Injection Defibrotide Injection Drospirenone may decrease the anticoagulant activities of Defibrotide.
Brivaracetam Injection Brivaracetam Injection The metabolism of Brivaracetam can be increased when combined with Drospirenone.
Venetoclax Venetoclax The metabolism of Venetoclax can be decreased when combined with Drospirenone.
Cobicistat Cobicistat The serum concentration of Drospirenone can be decreased when it is combined with Cobicistat.
Obeticholic Acid Obeticholic Acid The therapeutic efficacy of Obeticholic acid can be decreased when used in combination with Drospirenone.
Furosemide Injection Furosemide Injection Drospirenone may increase the excretion rate of Furosemide which could result in a lower serum level and potentially a reduction in efficacy.
Rucaparib Rucaparib The metabolism of Drospirenone can be decreased when combined with Rucaparib.
Lixisenatide Injection Lixisenatide Injection The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Drospirenone.
Ribociclib Ribociclib The metabolism of Drospirenone can be decreased when combined with Ribociclib.
Brigatinib Brigatinib The metabolism of Drospirenone can be decreased when combined with Brigatinib.
Doxepin (Insomnia) Doxepin (Insomnia) Drospirenone may increase the excretion rate of Doxepin which could result in a lower serum level and potentially a reduction in efficacy.
Plecanatide Plecanatide The risk or severity of adverse effects can be increased when Drospirenone is combined with Plecanatide.
Deutetrabenazine Deutetrabenazine Drospirenone may increase the excretion rate of Deutetrabenazine which could result in a lower serum level and potentially a reduction in efficacy.
Valbenazine Valbenazine Drospirenone may increase the excretion rate of Valbenazine which could result in a lower serum level and potentially a reduction in efficacy.
Deflazacort Deflazacort The serum concentration of Deflazacort can be increased when it is combined with Drospirenone.
Naldemedine Naldemedine Drospirenone may increase the excretion rate of Naldemedine which could result in a lower serum level and potentially a reduction in efficacy.
Sarilumab Injection Sarilumab Injection The metabolism of Drospirenone can be increased when combined with Sarilumab.
Midostaurin Midostaurin The metabolism of Drospirenone can be decreased when combined with Midostaurin.
Neratinib Neratinib The metabolism of Neratinib can be decreased when combined with Drospirenone.
Enasidenib Enasidenib The metabolism of Drospirenone can be decreased when combined with Enasidenib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Drospirenone can be increased when combined with Fosaprepitant.
Benznidazole Benznidazole Drospirenone may increase the excretion rate of Benznidazole which could result in a lower serum level and potentially a reduction in efficacy.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Drospirenone.
Delafloxacin Delafloxacin Drospirenone may increase the excretion rate of Delafloxacin which could result in a lower serum level and potentially a reduction in efficacy.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Drospirenone.
Betrixaban Betrixaban Drospirenone may decrease the anticoagulant activities of Betrixaban.
Acalabrutinib Acalabrutinib The metabolism of Drospirenone can be decreased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Drospirenone can be decreased when combined with Letermovir.
Semaglutide Injection Semaglutide Injection The therapeutic efficacy of Semaglutide can be decreased when used in combination with Drospirenone.
Ertugliflozin Ertugliflozin The therapeutic efficacy of Ertugliflozin can be decreased when used in combination with Drospirenone.
Buprenorphine Injection Buprenorphine Injection The therapeutic efficacy of Drospirenone can be decreased when used in combination with Buprenorphine.
Apalutamide Apalutamide The metabolism of Drospirenone can be increased when combined with Apalutamide.
Fostamatinib Fostamatinib The metabolism of Drospirenone can be decreased when combined with Fostamatinib.
Baricitinib Baricitinib The metabolism of Baricitinib can be decreased when combined with Drospirenone.
Lofexidine Lofexidine Drospirenone may increase the excretion rate of Lofexidine which could result in a lower serum level and potentially a reduction in efficacy.
Plazomicin Injection Plazomicin Injection Drospirenone may increase the excretion rate of Plazomicin which could result in a lower serum level and potentially a reduction in efficacy.
Ivosidenib Ivosidenib The metabolism of Drospirenone can be decreased when combined with Ivosidenib.
Eravacycline Injection Eravacycline Injection The serum concentration of Eravacycline can be decreased when it is combined with Drospirenone.
Cannabidiol Cannabidiol The metabolism of Cannabidiol can be increased when combined with Drospirenone.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Drospirenone.
Duvelisib Duvelisib The metabolism of Duvelisib can be decreased when combined with Drospirenone.
Omadacycline Omadacycline The serum concentration of Drospirenone can be decreased when it is combined with Omadacycline.
Sarecycline Sarecycline The serum concentration of Drospirenone can be decreased when it is combined with Sarecycline.
Stiripentol Stiripentol The metabolism of Drospirenone can be increased when combined with Stiripentol.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be decreased when combined with Drospirenone.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Drospirenone.
Rifamycin Rifamycin The metabolism of Drospirenone can be increased when combined with Rifamycin.
Prucalopride Prucalopride The serum concentration of Drospirenone can be decreased when it is combined with Prucalopride.
Calaspargase pegol-mknl Injection Calaspargase pegol-mknl Injection The therapeutic efficacy of Drospirenone can be decreased when used in combination with Calaspargase pegol.
Magnesium Citrate Magnesium Citrate The risk or severity of adverse effects can be increased when Drospirenone is combined with Magnesium citrate.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Drospirenone can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Drospirenone.
Acyclovir Ophthalmic Acyclovir Ophthalmic Drospirenone may increase the excretion rate of Acyclovir which could result in a lower serum level and potentially a reduction in efficacy.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Drospirenone.
Alpelisib Alpelisib The metabolism of Drospirenone can be decreased when combined with Alpelisib.
Brexanolone Injection Brexanolone Injection The metabolism of Drospirenone can be increased when combined with Brexanolone.
Solriamfetol Solriamfetol Drospirenone may increase the excretion rate of Solriamfetol which could result in a lower serum level and potentially a reduction in efficacy.
Triclabendazole Triclabendazole The metabolism of Drospirenone can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The metabolism of Entrectinib can be decreased when combined with Drospirenone.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Drospirenone.
Pitolisant Pitolisant The serum concentration of Drospirenone can be decreased when it is combined with Pitolisant.
Lefamulin Lefamulin The metabolism of Lefamulin can be decreased when combined with Drospirenone.
Phenytoin Injection Phenytoin Injection The metabolism of Drospirenone can be increased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Drospirenone can be increased when combined with Fosphenytoin.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Drospirenone.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Drospirenone.
Cenobamate Cenobamate The serum concentration of Drospirenone can be decreased when it is combined with Cenobamate.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Drospirenone.
Octreotide Octreotide The therapeutic efficacy of Drospirenone can be decreased when used in combination with Octreotide.
Pralsetinib Pralsetinib The metabolism of Drospirenone can be increased when combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Drospirenone can be decreased when it is combined with Satralizumab.
Viloxazine Viloxazine Drospirenone may increase the excretion rate of Viloxazine which could result in a lower serum level and potentially a reduction in efficacy.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The metabolism of Drospirenone can be increased when combined with Vitamin E.
Theophylline Theophylline Drospirenone may decrease the excretion rate of Theophylline which could result in a higher serum level.
Fenoprofen Fenoprofen The risk or severity of hyperkalemia can be increased when Fenoprofen is combined with Drospirenone.
Indomethacin Indomethacin The risk or severity of hyperkalemia can be increased when Indomethacin is combined with Drospirenone.
Mefenamic Acid Mefenamic Acid The risk or severity of hyperkalemia can be increased when Mefenamic acid is combined with Drospirenone.
Naproxen Naproxen The risk or severity of hyperkalemia can be increased when Naproxen is combined with Drospirenone.
Tolmetin Tolmetin The risk or severity of hyperkalemia can be increased when Tolmetin is combined with Drospirenone.
Sulindac Sulindac The risk or severity of hyperkalemia can be increased when Sulindac is combined with Drospirenone.
Isotretinoin Isotretinoin The therapeutic efficacy of Drospirenone can be decreased when used in combination with Isotretinoin.
Sucralfate Sucralfate Drospirenone may increase the excretion rate of Sucralfate which could result in a lower serum level and potentially a reduction in efficacy.
Floxuridine Floxuridine Drospirenone may increase the excretion rate of Floxuridine which could result in a lower serum level and potentially a reduction in efficacy.
Phenobarbital Phenobarbital The metabolism of Drospirenone can be increased when combined with Phenobarbital.
Metaxalone Metaxalone Drospirenone may increase the excretion rate of Metaxalone which could result in a lower serum level and potentially a reduction in efficacy.
Methotrexate Injection Methotrexate Injection The metabolism of Methotrexate can be decreased when combined with Drospirenone.
Levorphanol Levorphanol The therapeutic efficacy of Drospirenone can be decreased when used in combination with Levorphanol.
Primidone Primidone The metabolism of Drospirenone can be increased when combined with Primidone.
Methsuximide Methsuximide The metabolism of Methsuximide can be increased when combined with Drospirenone.
Chlorpromazine Chlorpromazine The metabolism of Drospirenone can be increased when combined with Chlorpromazine.
Diazepam Diazepam The metabolism of Drospirenone can be increased when combined with Diazepam.
Oxazepam Oxazepam Drospirenone may increase the excretion rate of Oxazepam which could result in a lower serum level and potentially a reduction in efficacy.
Flurazepam Flurazepam Drospirenone may increase the excretion rate of Flurazepam which could result in a lower serum level and potentially a reduction in efficacy.
Clorazepate Clorazepate The metabolism of Drospirenone can be increased when combined with Clorazepic acid.
Lorazepam Lorazepam The metabolism of Drospirenone can be increased when combined with Lorazepam.
Carmustine Carmustine Drospirenone may increase the excretion rate of Carmustine which could result in a lower serum level and potentially a reduction in efficacy.
Amantadine Amantadine Drospirenone may increase the excretion rate of Amantadine which could result in a lower serum level and potentially a reduction in efficacy.
Codeine Codeine The therapeutic efficacy of Drospirenone can be decreased when used in combination with Codeine.
Bromocriptine Bromocriptine The therapeutic efficacy of Bromocriptine can be decreased when used in combination with Drospirenone.
Tranylcypromine Tranylcypromine The metabolism of Drospirenone can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Drospirenone can be decreased when combined with Phenelzine.
Tetracycline Tetracycline The serum concentration of Drospirenone can be decreased when it is combined with Tetracycline.
Minocycline Minocycline The serum concentration of Drospirenone can be decreased when it is combined with Minocycline.
Demeclocycline Demeclocycline The serum concentration of Drospirenone can be decreased when it is combined with Demeclocycline.
Prochlorperazine Prochlorperazine The metabolism of Drospirenone can be decreased when combined with Prochlorperazine.
Bleomycin Bleomycin Drospirenone may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy.
Sulfadiazine Sulfadiazine The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Drospirenone.
Oxycodone Oxycodone The therapeutic efficacy of Drospirenone can be decreased when used in combination with Oxycodone.
Methadone Methadone The metabolism of Drospirenone can be decreased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Drospirenone can be decreased when combined with Oxybutynin.
Benztropine Benztropine Drospirenone may increase the excretion rate of Benzatropine which could result in a lower serum level and potentially a reduction in efficacy.
Colestipol Colestipol Colestipol can cause a decrease in the absorption of Drospirenone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Maprotiline Maprotiline Drospirenone may increase the excretion rate of Maprotiline which could result in a lower serum level and potentially a reduction in efficacy.
Ibuprofen Ibuprofen The risk or severity of hyperkalemia can be increased when Ibuprofen is combined with Drospirenone.
Orphenadrine Orphenadrine The metabolism of Drospirenone can be decreased when combined with Orphenadrine.
Azathioprine Azathioprine Drospirenone may increase the excretion rate of Azathioprine which could result in a lower serum level and potentially a reduction in efficacy.
Phentermine Phentermine The metabolism of Drospirenone can be decreased when combined with Phentermine.
Methylphenidate Methylphenidate Drospirenone may increase the excretion rate of Methylphenidate which could result in a lower serum level and potentially a reduction in efficacy.
Sulfasalazine Sulfasalazine The risk or severity of hyperkalemia can be increased when Sulfasalazine is combined with Drospirenone.
Hydrocortisone Hydrocortisone The serum concentration of Drospirenone can be increased when it is combined with Hydrocortisone.
Doxorubicin Doxorubicin The metabolism of Drospirenone can be decreased when combined with Doxorubicin.
Phenazopyridine Phenazopyridine Drospirenone may increase the excretion rate of Phenazopyridine which could result in a lower serum level and potentially a reduction in efficacy.
Carbamazepine Carbamazepine The serum concentration of Drospirenone can be decreased when it is combined with Carbamazepine.
Methyldopa Methyldopa Drospirenone may increase the excretion rate of Methyldopa which could result in a lower serum level and potentially a reduction in efficacy.
Clonidine Clonidine The metabolism of Clonidine can be decreased when combined with Drospirenone.
Hydralazine Hydralazine The metabolism of Drospirenone can be decreased when combined with Hydralazine.
Cimetidine Cimetidine Drospirenone may increase the excretion rate of Cimetidine which could result in a lower serum level and potentially a reduction in efficacy.
Warfarin Warfarin The metabolism of Warfarin can be decreased when combined with Drospirenone.
Clonazepam Clonazepam The metabolism of Clonazepam can be increased when combined with Drospirenone.
Loperamide Loperamide The metabolism of Drospirenone can be decreased when combined with Loperamide.
Promethazine Promethazine Drospirenone may increase the excretion rate of Promethazine which could result in a lower serum level and potentially a reduction in efficacy.
Meclofenamate Meclofenamate The risk or severity of hyperkalemia can be increased when Meclofenamic acid is combined with Drospirenone.
Daunorubicin Daunorubicin The metabolism of Drospirenone can be decreased when combined with Daunorubicin.
Nitrofurantoin Nitrofurantoin Nitrofurantoin may increase the excretion rate of Drospirenone which could result in a lower serum level and potentially a reduction in efficacy.
Griseofulvin Griseofulvin The metabolism of Drospirenone can be increased when combined with Griseofulvin.
Digoxin Digoxin Digoxin may increase the excretion rate of Drospirenone which could result in a lower serum level and potentially a reduction in efficacy.
Chloroquine Chloroquine Drospirenone may increase the excretion rate of Chloroquine which could result in a lower serum level and potentially a reduction in efficacy.
Quinine Quinine The therapeutic efficacy of Quinine can be decreased when used in combination with Drospirenone.
Ethosuximide Ethosuximide The metabolism of Ethosuximide can be increased when combined with Drospirenone.
Calcitriol Calcitriol The metabolism of Drospirenone can be increased when combined with Calcitriol.
Triamterene Triamterene The risk or severity of hyperkalemia can be increased when Triamterene is combined with Drospirenone.
Lactulose Lactulose The risk or severity of adverse effects can be increased when Drospirenone is combined with Lactulose.
Sulfinpyrazone Sulfinpyrazone The metabolism of Drospirenone can be increased when combined with Sulfinpyrazone.
Metolazone Metolazone Drospirenone may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Secobarbital Secobarbital The metabolism of Drospirenone can be increased when combined with Secobarbital.
Desipramine Desipramine The metabolism of Drospirenone can be decreased when combined with Desipramine.
Amitriptyline Amitriptyline Drospirenone may increase the excretion rate of Amitriptyline which could result in a lower serum level and potentially a reduction in efficacy.
Imipramine Imipramine Drospirenone may increase the excretion rate of Imipramine which could result in a lower serum level and potentially a reduction in efficacy.
Probenecid Probenecid The metabolism of Drospirenone can be increased when combined with Probenecid.
Quinidine Quinidine The metabolism of Quinidine can be decreased when combined with Drospirenone.
Procainamide Procainamide Drospirenone may increase the excretion rate of Procainamide which could result in a lower serum level and potentially a reduction in efficacy.
Isoniazid Isoniazid The metabolism of Drospirenone can be decreased when combined with Isoniazid.
Pyrazinamide Pyrazinamide Drospirenone may increase the excretion rate of Pyrazinamide which could result in a lower serum level and potentially a reduction in efficacy.
Rifampin Rifampin The metabolism of Rifampicin can be increased when combined with Drospirenone.
Disopyramide Disopyramide The therapeutic efficacy of Disopyramide can be decreased when used in combination with Drospirenone.
Valproic Acid Valproic Acid The metabolism of Drospirenone can be increased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Drospirenone can be decreased when combined with Tamoxifen.
Butabarbital Butabarbital Drospirenone may increase the excretion rate of Butabarbital which could result in a lower serum level and potentially a reduction in efficacy.
Liothyronine Liothyronine Drospirenone may increase the excretion rate of Liothyronine which could result in a lower serum level and potentially a reduction in efficacy.
Methimazole Methimazole The metabolism of Methimazole can be decreased when combined with Drospirenone.
Chlorpropamide Chlorpropamide The therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Drospirenone.
Tolbutamide Tolbutamide The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Drospirenone.
Tolazamide Tolazamide The therapeutic efficacy of Tolazamide can be decreased when used in combination with Drospirenone.
Niacin Niacin The metabolism of Drospirenone can be decreased when combined with Niacin.
Baclofen Baclofen Drospirenone may increase the excretion rate of Baclofen which could result in a lower serum level and potentially a reduction in efficacy.
Ethambutol Ethambutol Drospirenone may increase the excretion rate of Ethambutol which could result in a lower serum level and potentially a reduction in efficacy.
Dantrolene Dantrolene The risk or severity of hyperkalemia can be increased when Dantrolene is combined with Drospirenone.
Chlorzoxazone Chlorzoxazone Drospirenone may increase the excretion rate of Chlorzoxazone which could result in a lower serum level and potentially a reduction in efficacy.
Pyridoxine Pyridoxine Drospirenone may increase the excretion rate of Pyridoxine which could result in a lower serum level and potentially a reduction in efficacy.
Folic Acid Folic Acid Drospirenone may increase the excretion rate of Folic acid which could result in a lower serum level and potentially a reduction in efficacy.
Danazol Danazol The metabolism of Drospirenone can be decreased when combined with Danazol.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Propranolol may increase the excretion rate of Drospirenone which could result in a lower serum level and potentially a reduction in efficacy.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be decreased when combined with Drospirenone.
Spironolactone Spironolactone The risk or severity of hyperkalemia can be increased when Spironolactone is combined with Drospirenone.
Amphotericin B Injection Amphotericin B Injection The metabolism of Drospirenone can be decreased when combined with Amphotericin B.
Phytonadione Phytonadione Drospirenone may increase the excretion rate of Phylloquinone which could result in a lower serum level and potentially a reduction in efficacy.
Nadolol Nadolol Nadolol may increase the excretion rate of Drospirenone which could result in a lower serum level and potentially a reduction in efficacy.
Butorphanol Injection Butorphanol Injection The therapeutic efficacy of Drospirenone can be decreased when used in combination with Butorphanol.
Nalbuphine Injection Nalbuphine Injection The therapeutic efficacy of Drospirenone can be decreased when used in combination with Nalbuphine.
Cholestyramine Resin Cholestyramine Resin Cholestyramine can cause a decrease in the absorption of Drospirenone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Allopurinol Allopurinol Drospirenone may increase the excretion rate of Allopurinol which could result in a lower serum level and potentially a reduction in efficacy.
Flavoxate Flavoxate Drospirenone may increase the excretion rate of Flavoxate which could result in a lower serum level and potentially a reduction in efficacy.
Colchicine Colchicine The metabolism of Drospirenone can be increased when combined with Colchicine.
Cefaclor Cefaclor Drospirenone may increase the excretion rate of Cefaclor which could result in a lower serum level and potentially a reduction in efficacy.
Cefadroxil Cefadroxil Drospirenone may increase the excretion rate of Cefadroxil which could result in a lower serum level and potentially a reduction in efficacy.
Cephalexin Cephalexin The metabolism of Drospirenone can be decreased when combined with Cephalexin.
Dacarbazine Dacarbazine Drospirenone may increase the excretion rate of Dacarbazine which could result in a lower serum level and potentially a reduction in efficacy.
Acetazolamide Acetazolamide The metabolism of Drospirenone can be increased when combined with Acetazolamide.
Calcitonin Salmon Injection Calcitonin Salmon Injection Drospirenone may increase the excretion rate of Salmon calcitonin which could result in a lower serum level and potentially a reduction in efficacy.
Ketoconazole Ketoconazole The metabolism of Drospirenone can be decreased when combined with Ketoconazole.
Pyrantel Pyrantel Drospirenone may increase the excretion rate of Pyrantel which could result in a lower serum level and potentially a reduction in efficacy.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Drospirenone.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be decreased when combined with Drospirenone.
Captopril Captopril Captopril may increase the hyperkalemic activities of Drospirenone.
Dipyridamole Dipyridamole Drospirenone may decrease the anticoagulant activities of Dipyridamole.
Vinblastine Vinblastine The metabolism of Drospirenone can be decreased when combined with Vinblastine.
Metoprolol Metoprolol Metoprolol may increase the excretion rate of Drospirenone which could result in a lower serum level and potentially a reduction in efficacy.
Aspirin Aspirin The risk or severity of hyperkalemia can be increased when Acetylsalicylic acid is combined with Drospirenone.
Salsalate Salsalate The risk or severity of hyperkalemia can be increased when Salsalate is combined with Drospirenone.
Alprazolam Alprazolam Drospirenone may increase the excretion rate of Alprazolam which could result in a lower serum level and potentially a reduction in efficacy.
Temazepam Temazepam Drospirenone may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
Triazolam Triazolam Drospirenone may increase the excretion rate of Triazolam which could result in a lower serum level and potentially a reduction in efficacy.
Dicyclomine Dicyclomine Drospirenone may increase the excretion rate of Dicyclomine which could result in a lower serum level and potentially a reduction in efficacy.
Propantheline Propantheline Drospirenone may increase the excretion rate of Propantheline which could result in a lower serum level and potentially a reduction in efficacy.
Trimethoprim Trimethoprim Trimethoprim may increase the excretion rate of Drospirenone which could result in a lower serum level and potentially a reduction in efficacy.
Diltiazem Diltiazem The metabolism of Drospirenone can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Drospirenone can be increased when combined with Nifedipine.
Timolol Timolol Timolol may increase the excretion rate of Drospirenone which could result in a lower serum level and potentially a reduction in efficacy.
Verapamil Verapamil The metabolism of Drospirenone can be decreased when combined with Verapamil.
Atenolol Atenolol The risk or severity of hyperkalemia can be increased when Atenolol is combined with Drospirenone.
Pindolol Pindolol Pindolol may increase the excretion rate of Drospirenone which could result in a lower serum level and potentially a reduction in efficacy.
Cisplatin Injection Cisplatin Injection Drospirenone may increase the excretion rate of Cisplatin which could result in a lower serum level and potentially a reduction in efficacy.
Diflunisal Diflunisal The risk or severity of hyperkalemia can be increased when Diflunisal is combined with Drospirenone.
Piroxicam Piroxicam The risk or severity of hyperkalemia can be increased when Piroxicam is combined with Drospirenone.
Bumetanide Bumetanide Drospirenone may increase the excretion rate of Bumetanide which could result in a lower serum level and potentially a reduction in efficacy.
Etoposide Etoposide The metabolism of Drospirenone can be decreased when combined with Etoposide.
Glyburide Glyburide The therapeutic efficacy of Glyburide can be decreased when used in combination with Drospirenone.
Glipizide Glipizide The therapeutic efficacy of Glipizide can be decreased when used in combination with Drospirenone.
Indapamide Indapamide Drospirenone may increase the excretion rate of Indapamide which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin Amoxicillin Amoxicillin may increase the excretion rate of Drospirenone which could result in a lower serum level and potentially a reduction in efficacy.
Dicloxacillin Dicloxacillin The metabolism of Drospirenone can be increased when combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The metabolism of Drospirenone can be increased when combined with Nafcillin.
Oxacillin Injection Oxacillin Injection Oxacillin may increase the excretion rate of Drospirenone which could result in a lower serum level and potentially a reduction in efficacy.
Pentoxifylline Pentoxifylline Drospirenone may increase the excretion rate of Pentoxifylline which could result in a lower serum level and potentially a reduction in efficacy.
Pentamidine Injection Pentamidine Injection The therapeutic efficacy of Pentamidine can be decreased when used in combination with Drospirenone.
Ceftriaxone Injection Ceftriaxone Injection Drospirenone may increase the excretion rate of Ceftriaxone which could result in a lower serum level and potentially a reduction in efficacy.
Labetalol Labetalol Labetalol may increase the excretion rate of Drospirenone which could result in a lower serum level and potentially a reduction in efficacy.
Auranofin Auranofin Drospirenone may increase the excretion rate of Auranofin which could result in a lower serum level and potentially a reduction in efficacy.
Leuprolide Injection Leuprolide Injection Drospirenone may increase the excretion rate of Leuprolide which could result in a lower serum level and potentially a reduction in efficacy.
Gemfibrozil Gemfibrozil Drospirenone may increase the excretion rate of Gemfibrozil which could result in a lower serum level and potentially a reduction in efficacy.
Ceftazidime Injection Ceftazidime Injection Drospirenone may increase the excretion rate of Ceftazidime which could result in a lower serum level and potentially a reduction in efficacy.
Ketoprofen Ketoprofen The risk or severity of hyperkalemia can be increased when Ketoprofen is combined with Drospirenone.
Cefotetan Injection Cefotetan Injection Drospirenone may increase the excretion rate of Cefotetan which could result in a lower serum level and potentially a reduction in efficacy.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Drospirenone.
Enalapril Enalapril Enalapril may increase the hyperkalemic activities of Drospirenone.
Flurbiprofen Flurbiprofen The risk or severity of hyperkalemia can be increased when Flurbiprofen is combined with Drospirenone.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Drospirenone.
Aztreonam Injection Aztreonam Injection Drospirenone may increase the excretion rate of Aztreonam which could result in a lower serum level and potentially a reduction in efficacy.
Buspirone Buspirone Drospirenone may increase the excretion rate of Buspirone which could result in a lower serum level and potentially a reduction in efficacy.
Lovastatin Lovastatin The metabolism of Drospirenone can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin Drospirenone may increase the excretion rate of Ciprofloxacin which could result in a lower serum level and potentially a reduction in efficacy.
Mesalamine Mesalamine The risk or severity of hyperkalemia can be increased when Mesalazine is combined with Drospirenone.
Diclofenac Diclofenac The risk or severity of hyperkalemia can be increased when Diclofenac is combined with Drospirenone.
Nimodipine Nimodipine The risk or severity of hyperkalemia can be increased when Nimodipine is combined with Drospirenone.
Clozapine Clozapine The metabolism of Drospirenone can be increased when combined with Clozapine.
Estazolam Estazolam The metabolism of Drospirenone can be increased when combined with Estazolam.
Didanosine Didanosine Drospirenone may increase the excretion rate of Didanosine which could result in a lower serum level and potentially a reduction in efficacy.
Pentostatin Injection Pentostatin Injection Drospirenone may increase the excretion rate of Pentostatin which could result in a lower serum level and potentially a reduction in efficacy.
Clarithromycin Clarithromycin The metabolism of Drospirenone can be decreased when combined with Clarithromycin.
Benazepril Benazepril Benazepril may increase the hyperkalemic activities of Drospirenone.
Etodolac Etodolac The risk or severity of hyperkalemia can be increased when Etodolac is combined with Drospirenone.
Felodipine Felodipine The metabolism of Drospirenone can be decreased when combined with Felodipine.
Fosinopril Fosinopril Fosinopril may increase the hyperkalemic activities of Drospirenone.
Nabumetone Nabumetone The risk or severity of hyperkalemia can be increased when Nabumetone is combined with Drospirenone.
Quinapril Quinapril Quinapril may increase the hyperkalemic activities of Drospirenone.
Ramipril Ramipril Ramipril may increase the hyperkalemic activities of Drospirenone.
Amlodipine Amlodipine The risk or severity of hyperkalemia can be increased when Drospirenone is combined with Amlodipine.
Teniposide Injection Teniposide Injection The metabolism of Drospirenone can be decreased when combined with Teniposide.
Itraconazole Itraconazole The metabolism of Drospirenone can be decreased when combined with Itraconazole.
Lisinopril Lisinopril Lisinopril may increase the hyperkalemic activities of Drospirenone.
Oxaprozin Oxaprozin The risk or severity of hyperkalemia can be increased when Oxaprozin is combined with Drospirenone.
Rifabutin Rifabutin The metabolism of Drospirenone can be increased when combined with Rifabutin.
Sotalol Sotalol The risk or severity of hyperkalemia can be increased when Sotalol is combined with Drospirenone.
Bisoprolol Bisoprolol Bisoprolol may increase the excretion rate of Drospirenone which could result in a lower serum level and potentially a reduction in efficacy.
Doxazosin Doxazosin The metabolism of Drospirenone can be decreased when combined with Doxazosin.
Isradipine Isradipine Isradipine may increase the excretion rate of Drospirenone which could result in a lower serum level and potentially a reduction in efficacy.
Omeprazole Omeprazole The metabolism of Drospirenone can be increased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Drospirenone can be decreased when combined with Cisapride.
Gabapentin Gabapentin The metabolism of Drospirenone can be increased when combined with Gabapentin.
Fluvastatin Fluvastatin The metabolism of Drospirenone can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine Drospirenone may increase the excretion rate of Venlafaxine which could result in a lower serum level and potentially a reduction in efficacy.
Famciclovir Famciclovir The metabolism of Drospirenone can be decreased when combined with Famciclovir.
Fluvoxamine Fluvoxamine The metabolism of Drospirenone can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The metabolism of Drospirenone can be decreased when combined with Nefazodone.
Lamotrigine Lamotrigine The metabolism of Drospirenone can be increased when combined with Lamotrigine.
Losartan Losartan The risk or severity of hyperkalemia can be increased when Losartan is combined with Drospirenone.
Valacyclovir Valacyclovir Drospirenone may increase the excretion rate of Valaciclovir which could result in a lower serum level and potentially a reduction in efficacy.
Tramadol Tramadol The therapeutic efficacy of Drospirenone can be decreased when used in combination with Tramadol.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be decreased when combined with Drospirenone.
Carboplatin Injection Carboplatin Injection Drospirenone may increase the excretion rate of Carboplatin which could result in a lower serum level and potentially a reduction in efficacy.
Moexipril Moexipril Moexipril may increase the hyperkalemic activities of Drospirenone.
Lansoprazole Lansoprazole The metabolism of Drospirenone can be increased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Drospirenone.
Nicardipine Nicardipine The metabolism of Drospirenone can be decreased when combined with Nicardipine.
Bupropion Bupropion Drospirenone may increase the excretion rate of Bupropion which could result in a lower serum level and potentially a reduction in efficacy.
Ticlopidine Ticlopidine The metabolism of Drospirenone can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The metabolism of Saquinavir can be decreased when combined with Drospirenone.
Metformin Metformin The therapeutic efficacy of Metformin can be decreased when used in combination with Drospirenone.
Dalteparin Injection Dalteparin Injection Drospirenone may decrease the anticoagulant activities of Dalteparin.
Nisoldipine Nisoldipine Nisoldipine may increase the excretion rate of Drospirenone which could result in a lower serum level and potentially a reduction in efficacy.
Lamivudine Lamivudine Drospirenone may increase the excretion rate of Lamivudine which could result in a lower serum level and potentially a reduction in efficacy.
Riluzole Riluzole The metabolism of Drospirenone can be increased when combined with Riluzole.
Acarbose Acarbose The therapeutic efficacy of Acarbose can be decreased when used in combination with Drospirenone.
Glimepiride Glimepiride The therapeutic efficacy of Glimepiride can be decreased when used in combination with Drospirenone.
Gemcitabine Injection Gemcitabine Injection Drospirenone may increase the excretion rate of Gemcitabine which could result in a lower serum level and potentially a reduction in efficacy.
Ritonavir Ritonavir The serum concentration of Drospirenone can be decreased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Drospirenone can be decreased when combined with Docetaxel.
Cidofovir Injection Cidofovir Injection Drospirenone may increase the excretion rate of Cidofovir which could result in a lower serum level and potentially a reduction in efficacy.
Meropenem Injection Meropenem Injection Drospirenone may increase the excretion rate of Meropenem which could result in a lower serum level and potentially a reduction in efficacy.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Drospirenone.
Zafirlukast Zafirlukast The metabolism of Drospirenone can be decreased when combined with Zafirlukast.
Fosfomycin Fosfomycin Drospirenone may increase the excretion rate of Fosfomycin which could result in a lower serum level and potentially a reduction in efficacy.
Mirtazapine Mirtazapine The metabolism of Drospirenone can be decreased when combined with Mirtazapine.
Trandolapril Trandolapril Trandolapril may increase the hyperkalemic activities of Drospirenone.
Topiramate Topiramate The metabolism of Drospirenone can be increased when combined with Topiramate.
Valsartan Valsartan The risk or severity of hyperkalemia can be increased when Valsartan is combined with Drospirenone.
Insulin Lispro Injection Insulin Lispro Injection The therapeutic efficacy of Insulin lispro can be decreased when used in combination with Drospirenone.
Pramipexole Pramipexole Drospirenone may increase the excretion rate of Pramipexole which could result in a lower serum level and potentially a reduction in efficacy.
Azithromycin Azithromycin The metabolism of Drospirenone can be decreased when combined with Azithromycin.
Carvedilol Carvedilol The risk or severity of hyperkalemia can be increased when Carvedilol is combined with Drospirenone.
Nilutamide Nilutamide Drospirenone may increase the excretion rate of Nilutamide which could result in a lower serum level and potentially a reduction in efficacy.
Flutamide Flutamide Drospirenone may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Selegiline Selegiline The bioavailability of Selegiline can be increased when combined with Drospirenone.
Bicalutamide Bicalutamide The metabolism of Drospirenone can be decreased when combined with Bicalutamide.
Propafenone Propafenone The risk or severity of hyperkalemia can be increased when Propafenone is combined with Drospirenone.
Raloxifene Raloxifene The metabolism of Drospirenone can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The risk or severity of hyperkalemia can be increased when Irbesartan is combined with Drospirenone.
Tamsulosin Tamsulosin Drospirenone may increase the excretion rate of Tamsulosin which could result in a lower serum level and potentially a reduction in efficacy.
Quetiapine Quetiapine Drospirenone may increase the excretion rate of Quetiapine which could result in a lower serum level and potentially a reduction in efficacy.
Cetirizine Cetirizine Drospirenone may increase the excretion rate of Cetirizine which could result in a lower serum level and potentially a reduction in efficacy.
Paroxetine Paroxetine The metabolism of Drospirenone can be decreased when combined with Paroxetine.
Tolcapone Tolcapone Drospirenone may increase the excretion rate of Tolcapone which could result in a lower serum level and potentially a reduction in efficacy.
Citalopram Citalopram The metabolism of Drospirenone can be decreased when combined with Citalopram.
Capecitabine Capecitabine Drospirenone may increase the excretion rate of Capecitabine which could result in a lower serum level and potentially a reduction in efficacy.
Efavirenz Efavirenz The metabolism of Drospirenone can be decreased when combined with Efavirenz.
Abacavir Abacavir Drospirenone may increase the excretion rate of Abacavir which could result in a lower serum level and potentially a reduction in efficacy.
Pioglitazone Pioglitazone The therapeutic efficacy of Pioglitazone can be decreased when used in combination with Drospirenone.
Celecoxib Celecoxib The risk or severity of hyperkalemia can be increased when Celecoxib is combined with Drospirenone.
Rosiglitazone Rosiglitazone The therapeutic efficacy of Rosiglitazone can be decreased when used in combination with Drospirenone.
Tolterodine Tolterodine Drospirenone may increase the excretion rate of Tolterodine which could result in a lower serum level and potentially a reduction in efficacy.
Thalidomide Thalidomide Drospirenone may increase the thrombogenic activities of Thalidomide.
Oseltamivir Oseltamivir Drospirenone may increase the excretion rate of Oseltamivir which could result in a lower serum level and potentially a reduction in efficacy.
Colesevelam Colesevelam Colesevelam can cause a decrease in the absorption of Drospirenone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Balsalazide Balsalazide The risk or severity of hyperkalemia can be increased when Balsalazide is combined with Drospirenone.
Nateglinide Nateglinide The therapeutic efficacy of Nateglinide can be decreased when used in combination with Drospirenone.
Levetiracetam Levetiracetam The metabolism of Drospirenone can be increased when combined with Levetiracetam.
Rabeprazole Rabeprazole The metabolism of Drospirenone can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Drospirenone can be increased when combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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