Abemaciclib

Generic name: Pronounced as (a bem" a sye' klib)
Brand names
  • Verzenio®
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 01/15/2022

Abemaciclib is used in combination with an aromatase inhibitor such as anastrozole (Arimidex), exemestane (Aromasin), or letrozole (Femara) to treat a certain type of hormone receptor-positive, early breast cancer. Abemaciclib is also used along with fulvestrant (Faslodex) to treat a certain type of hormone receptor-positive, advanced breast cancer (breast cancer that depends on hormones such as estrogen to grow) or breast cancer that has spread to other parts of the body after treatment with an antiestrogen medication such as tamoxifen. Abemaciclib is also used along with anastrozole (Arimidex), exemestane (Aromasin), or letrozole (Femara) as a first treatment of hormone receptor-positive, advanced breast cancer or breast cancer that has spread to other parts of the body. Abemaciclib is also used alone to treat a certain type of hormone receptor-positive, advanced breast cancer or breast cancer that has spread to other parts of the body in people who have already been treated with an antiestrogen medication and chemotherapy. Abemaciclib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the spread of cancer cells.

Abemaciclib comes as a tablet to take by mouth. It is usually taken twice daily with or without food. Take abemaciclib at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take abemaciclib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablets whole; do not split, chew, or crush them. Do not take tablets that are broken, cracked, or damaged in any way.

If you vomit after taking abemaciclib, do not take another dose. Continue your regular dosing schedule.

Your doctor may decrease your dose or temporarily or permanently stop your treatment if you experience certain side effects. This depends on how well the medication works for you and the side effects you experience. Be sure to tell your doctor how you are feeling during your treatment with abemaciclib.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking abemaciclib,

  • tell your doctor and pharmacist if you are allergic to abemaciclib, any other medications, or any of the ingredients in abemaciclib tablets. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: clarithromycin (Biaxin), diltiazem (Cardizem, Tiazac, others), itraconazole (Sporanox), ketoconazole, rifampin (Rifadin, Rimactane), and verapamil (Calan, Verelan, others). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with abemaciclib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor if you have a fever, chills, or any other signs of an infection or if you have or have ever had blood clots, including a pulmonary embolism (PE; a blood clot in the lung); lung or breathing problem; or liver or kidney disease.

  • tell your doctor if you are pregnant or plan to become pregnant. You will need to take a pregnancy test before you start treatment and should use birth control to prevent pregnancy during your treatment and for at least 3 weeks after your final dose. If you become pregnant while taking abemaciclib, call your doctor immediately. Abemaciclib may harm the fetus.

  • tell your doctor if you are breastfeeding or plan to breastfeed. You should not breastfeed while taking abemaciclib and for at least 3 weeks after your final dose.

  • you should know that this medication may decrease fertility in men. Talk to your doctor about the risks of taking abemaciclib.

  • you should know that abemaciclib often causes diarrhea, which can be severe. Your doctor will probably tell you to drink plenty of liquids and to take anti-diarrhea medication to prevent dehydration (loss of too much water from your body) when you first experience diarrhea or loose stools. Call your doctor immediately if you experience any of the following symptoms of dehydration: extreme thirst, dry mouth or skin, decreased urination, or fast heartbeat.

Do not eat grapefruit or drink grapefruit juice while taking this medication.

Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Abemaciclib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • vomiting

    • stomach pain

    • constipation

    • sores on the lips, mouth, or throat

    • decreased appetite

    • weight loss

    • hair loss

    • itching

    • rash

    • headache

    • changes in taste

    • dizziness

    • joint pain

  • Some side effects can be serious. If you experience any of these symptoms or any in the SPECIAL PRECAUTIONS section, call your doctor immediately:

    • tiredness

    • pain in the upper right part of the stomach

    • yellowing of the skin or eyes

    • loss of appetite

    • bleeding or bruising easily

    • pain in arms or legs

    • swelling of the hands, feet, legs or ankles

    • difficulty breathing or shortness of breath

    • cough with or without mucus

    • chest pain

    • rapid breathing

    • fast, irregular, or pounding heartbeat

    • fever, chills, cough or other signs of infection

    • pale skin

  • Abemaciclib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests before and during your treatment to check your body's response to abemaciclib.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Leflunomide Leflunomide Abemaciclib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Delavirdine Delavirdine The metabolism of Abemaciclib can be decreased when combined with Delavirdine.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Abemaciclib can be decreased when combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Abemaciclib may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Fenofibrate Fenofibrate The metabolism of Abemaciclib can be decreased when combined with Fenofibrate.
Methylergonovine Methylergonovine The metabolism of Abemaciclib can be decreased when combined with Methylergometrine.
Paregoric Paregoric The serum concentration of Abemaciclib can be increased when it is combined with Morphine.
Reserpine Reserpine The serum concentration of Abemaciclib can be increased when it is combined with Reserpine.
Sumatriptan Sumatriptan Abemaciclib may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Tacrolimus Tacrolimus The metabolism of Abemaciclib can be decreased when combined with Tacrolimus.
Triamcinolone Triamcinolone The metabolism of Abemaciclib can be increased when combined with Triamcinolone.
Doxycycline Injection Doxycycline Injection The metabolism of Abemaciclib can be decreased when combined with Doxycycline.
Fluconazole Injection Fluconazole Injection The metabolism of Abemaciclib can be decreased when combined with Fluconazole.
Levofloxacin Injection Levofloxacin Injection The excretion of Abemaciclib can be decreased when combined with Levofloxacin.
Meperidine Injection Meperidine Injection The metabolism of Abemaciclib can be increased when combined with Meperidine.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Abemaciclib can be increased when combined with Methylprednisolone.
Metronidazole Injection Metronidazole Injection The metabolism of Abemaciclib can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The serum concentration of Abemaciclib can be increased when it is combined with Morphine.
Zidovudine Injection Zidovudine Injection Abemaciclib may decrease the excretion rate of Zidovudine which could result in a higher serum level.
Cyclosporine Cyclosporine The metabolism of Abemaciclib can be decreased when combined with Cyclosporine.
Orlistat Orlistat The metabolism of Abemaciclib can be increased when combined with Orlistat.
Oxcarbazepine Oxcarbazepine The metabolism of Abemaciclib can be increased when combined with Oxcarbazepine.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Abemaciclib which could result in a higher serum level.
Telmisartan Telmisartan Telmisartan may decrease the excretion rate of Abemaciclib which could result in a higher serum level.
Anakinra Anakinra The metabolism of Abemaciclib can be increased when combined with Anakinra.
Etanercept Injection Etanercept Injection The metabolism of Abemaciclib can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Abemaciclib can be increased when combined with Modafinil.
Tenofovir Tenofovir The metabolism of Abemaciclib can be decreased when combined with Tenofovir.
Sirolimus Sirolimus The serum concentration of Abemaciclib can be increased when it is combined with Sirolimus.
Epinephrine Injection Epinephrine Injection The metabolism of Abemaciclib can be decreased when combined with Epinephrine.
Zonisamide Zonisamide The serum concentration of Abemaciclib can be increased when it is combined with Zonisamide.
Adalimumab Injection Adalimumab Injection The metabolism of Abemaciclib can be increased when combined with Adalimumab.
Ezetimibe Ezetimibe Abemaciclib may decrease the excretion rate of Ezetimibe which could result in a higher serum level.
Atazanavir Atazanavir The metabolism of Abemaciclib can be decreased when combined with Atazanavir.
Mefloquine Mefloquine The metabolism of Abemaciclib can be decreased when combined with Mefloquine.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Abemaciclib.
Vardenafil Vardenafil The serum concentration of Abemaciclib can be increased when it is combined with Vardenafil.
Aprepitant Aprepitant The metabolism of Abemaciclib can be decreased when combined with Aprepitant.
Emtricitabine Emtricitabine The excretion of Abemaciclib can be decreased when combined with Emtricitabine.
Tegaserod Tegaserod Abemaciclib may decrease the excretion rate of Tegaserod which could result in a higher serum level.
Progesterone Progesterone The metabolism of Abemaciclib can be increased when combined with Progesterone.
Darbepoetin Alfa Injection Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Abemaciclib.
Infliximab Injection Infliximab Injection The metabolism of Abemaciclib can be increased when combined with Infliximab.
Rifaximin Rifaximin The metabolism of Abemaciclib can be increased when combined with Rifaximin.
Duloxetine Duloxetine The metabolism of Abemaciclib can be decreased when combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Abemaciclib can be decreased when combined with Norethisterone.
Bosentan Bosentan The metabolism of Abemaciclib can be increased when combined with Bosentan.
Erlotinib Erlotinib The metabolism of Abemaciclib can be decreased when combined with Erlotinib.
Ganciclovir Ganciclovir The excretion of Abemaciclib can be decreased when combined with Ganciclovir.
Voriconazole Voriconazole The metabolism of Abemaciclib can be decreased when combined with Voriconazole.
Deferasirox Deferasirox The metabolism of Abemaciclib can be increased when combined with Deferasirox.
Tipranavir Tipranavir The metabolism of Tipranavir can be decreased when combined with Abemaciclib.
Felbamate Felbamate The metabolism of Abemaciclib can be increased when combined with Felbamate.
Ranolazine Ranolazine The metabolism of Abemaciclib can be decreased when combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Abemaciclib can be increased when combined with Abatacept.
Imatinib Imatinib The metabolism of Abemaciclib can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The serum concentration of Abemaciclib can be increased when it is combined with Sitagliptin.
Gefitinib Gefitinib The metabolism of Abemaciclib can be decreased when combined with Gefitinib.
Paliperidone Paliperidone The serum concentration of Abemaciclib can be increased when it is combined with Paliperidone.
Bortezomib Bortezomib The serum concentration of Abemaciclib can be increased when it is combined with Bortezomib.
Clofarabine Injection Clofarabine Injection Abemaciclib may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Oxaliplatin Injection Oxaliplatin Injection Abemaciclib may decrease the excretion rate of Oxaliplatin which could result in a higher serum level.
Posaconazole Posaconazole The metabolism of Abemaciclib can be decreased when combined with Posaconazole.
Primaquine Primaquine The metabolism of Abemaciclib can be decreased when combined with Primaquine.
Darunavir Darunavir The serum concentration of Darunavir can be increased when it is combined with Abemaciclib.
Sorafenib Sorafenib The metabolism of Abemaciclib can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Abemaciclib can be decreased when combined with Sunitinib.
Dronabinol Dronabinol Dronabinol may decrease the excretion rate of Abemaciclib which could result in a higher serum level.
Lapatinib Lapatinib The metabolism of Abemaciclib can be decreased when combined with Lapatinib.
Dasatinib Dasatinib The metabolism of Abemaciclib can be decreased when combined with Dasatinib.
Armodafinil Armodafinil The metabolism of Abemaciclib can be increased when combined with Armodafinil.
Ivermectin Ivermectin The metabolism of Ivermectin can be increased when combined with Abemaciclib.
Temsirolimus Temsirolimus The serum concentration of Abemaciclib can be increased when it is combined with Temsirolimus.
Nilotinib Nilotinib The metabolism of Abemaciclib can be decreased when combined with Nilotinib.
Toremifene Toremifene The serum concentration of Abemaciclib can be increased when it is combined with Toremifene.
Bexarotene Bexarotene The metabolism of Abemaciclib can be increased when combined with Bexarotene.
Budesonide Budesonide The metabolism of Abemaciclib can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Abemaciclib can be decreased when combined with Chloramphenicol.
Etravirine Etravirine The metabolism of Abemaciclib can be increased when combined with Etravirine.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Mitoxantrone can be decreased when combined with Abemaciclib.
Desvenlafaxine Desvenlafaxine The metabolism of Abemaciclib can be decreased when combined with Desvenlafaxine.
Pilocarpine Pilocarpine The metabolism of Abemaciclib can be decreased when combined with Pilocarpine.
Flecainide Flecainide The excretion of Flecainide can be decreased when combined with Abemaciclib.
Certolizumab Injection Certolizumab Injection The metabolism of Abemaciclib can be increased when combined with Certolizumab pegol.
Irinotecan Injection Irinotecan Injection Abemaciclib may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Mitotane Mitotane The metabolism of Abemaciclib can be increased when combined with Mitotane.
Rufinamide Rufinamide The metabolism of Abemaciclib can be increased when combined with Rufinamide.
Silodosin Silodosin The serum concentration of Abemaciclib can be increased when it is combined with Silodosin.
Midazolam Midazolam The metabolism of Abemaciclib can be decreased when combined with Midazolam.
Eltrombopag Eltrombopag Eltrombopag may decrease the excretion rate of Abemaciclib which could result in a higher serum level.
Milnacipran Milnacipran The metabolism of Abemaciclib can be decreased when combined with Milnacipran.
Lacosamide Lacosamide The metabolism of Abemaciclib can be decreased when combined with Lacosamide.
Everolimus Everolimus The serum concentration of Abemaciclib can be increased when it is combined with Everolimus.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Abemaciclib can be increased when it is combined with Tolvaptan.
Dronedarone Dronedarone The serum concentration of Abemaciclib can be increased when it is combined with Dronedarone.
Pralatrexate Injection Pralatrexate Injection Abemaciclib may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Romidepsin Injection Romidepsin Injection The serum concentration of Abemaciclib can be increased when it is combined with Romidepsin.
Topotecan Topotecan The metabolism of Topotecan can be increased when combined with Abemaciclib.
Golimumab Injection Golimumab Injection The metabolism of Abemaciclib can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Pazopanib can be decreased when combined with Abemaciclib.
Pitavastatin Pitavastatin Abemaciclib may decrease the excretion rate of Pitavastatin which could result in a higher serum level.
Albendazole Albendazole The metabolism of Abemaciclib can be decreased when combined with Albendazole.
Tocilizumab Injection Tocilizumab Injection The metabolism of Abemaciclib can be increased when combined with Tocilizumab.
Cabazitaxel Injection Cabazitaxel Injection Cabazitaxel may decrease the excretion rate of Abemaciclib which could result in a higher serum level.
Acetaminophen Injection Acetaminophen Injection The metabolism of Abemaciclib can be increased when combined with Acetaminophen.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Abemaciclib can be decreased when combined with Aldesleukin.
Roflumilast Roflumilast The metabolism of Abemaciclib can be decreased when combined with Roflumilast.
Linagliptin Linagliptin The metabolism of Abemaciclib can be decreased when combined with Linagliptin.
Rilpivirine Rilpivirine The metabolism of Abemaciclib can be decreased when combined with Rilpivirine.
Telaprevir Telaprevir The metabolism of Glecaprevir can be decreased when combined with Abemaciclib.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Abemaciclib can be increased when combined with Cyclophosphamide.
Rivaroxaban Rivaroxaban Abemaciclib may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ticagrelor Ticagrelor The metabolism of Abemaciclib can be decreased when combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Abemaciclib can be decreased when combined with Brentuximab vedotin.
Vandetanib Vandetanib The serum concentration of Abemaciclib can be increased when it is combined with Vandetanib.
Clobazam Clobazam The metabolism of Abemaciclib can be increased when combined with Clobazam.
Vemurafenib Vemurafenib The metabolism of Abemaciclib can be increased when combined with Vemurafenib.
Vismodegib Vismodegib Vismodegib may decrease the excretion rate of Abemaciclib which could result in a higher serum level.
Ivacaftor Ivacaftor The metabolism of Abemaciclib can be decreased when combined with Ivacaftor.
Crizotinib Crizotinib The metabolism of Abemaciclib can be decreased when combined with Crizotinib.
Cabergoline Cabergoline The metabolism of Abemaciclib can be decreased when combined with Cabergoline.
Naloxone Injection Naloxone Injection The metabolism of Abemaciclib can be decreased when combined with Naloxone.
Ambrisentan Ambrisentan The serum concentration of Abemaciclib can be increased when it is combined with Ambrisentan.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Abemaciclib can be increased when it is combined with Carfilzomib.
Enzalutamide Enzalutamide The metabolism of Abemaciclib can be increased when combined with Enzalutamide.
Mirabegron Mirabegron The serum concentration of Abemaciclib can be increased when it is combined with Mirabegron.
Regorafenib Regorafenib The metabolism of Abemaciclib can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Abemaciclib can be decreased when combined with Bosutinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Abemaciclib can be increased when combined with Corticotropin.
Teriflunomide Teriflunomide Teriflunomide may decrease the excretion rate of Abemaciclib which could result in a higher serum level.
Ponatinib Ponatinib The serum concentration of Abemaciclib can be increased when it is combined with Ponatinib.
Pomalidomide Pomalidomide The serum concentration of Abemaciclib can be increased when it is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Abemaciclib can be decreased when combined with Trastuzumab emtansine.
Apixaban Apixaban Abemaciclib may decrease the excretion rate of Apixaban which could result in a higher serum level.
Canagliflozin Canagliflozin The serum concentration of Abemaciclib can be increased when it is combined with Canagliflozin.
Dabrafenib Dabrafenib The metabolism of Abemaciclib can be increased when combined with Dabrafenib.
Trametinib Trametinib The metabolism of Abemaciclib can be increased when combined with Trametinib.
Dolutegravir Dolutegravir Abemaciclib may decrease the excretion rate of Dolutegravir which could result in a higher serum level.
Afatinib Afatinib The serum concentration of Abemaciclib can be increased when it is combined with Afatinib.
Perampanel Perampanel The metabolism of Abemaciclib can be increased when combined with Perampanel.
Lomitapide Lomitapide The metabolism of Abemaciclib can be decreased when combined with Lomitapide.
Simeprevir Simeprevir The metabolism of Abemaciclib can be decreased when combined with Simeprevir.
Sofosbuvir Sofosbuvir Abemaciclib may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Apremilast Apremilast The metabolism of Abemaciclib can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Abemaciclib can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Abemaciclib can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The metabolism of Abemaciclib can be increased when combined with Eslicarbazepine.
Belinostat Injection Belinostat Injection The serum concentration of Abemaciclib can be increased when it is combined with Belinostat.
Idelalisib Idelalisib The metabolism of Idelalisib can be decreased when combined with Abemaciclib.
Testosterone Injection Testosterone Injection The metabolism of Testosterone can be increased when combined with Abemaciclib.
Oritavancin Injection Oritavancin Injection The metabolism of Abemaciclib can be increased when combined with Oritavancin.
Vorapaxar Vorapaxar The serum concentration of Abemaciclib can be increased when it is combined with Vorapaxar.
Suvorexant Suvorexant The serum concentration of Abemaciclib can be increased when it is combined with Suvorexant.
Edoxaban Edoxaban The serum concentration of Abemaciclib can be increased when it is combined with Edoxaban.
Olaparib Olaparib The metabolism of Abemaciclib can be decreased when combined with Olaparib.
Tasimelteon Tasimelteon The metabolism of Abemaciclib can be decreased when combined with Tasimelteon.
Riociguat Riociguat Abemaciclib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Lanreotide Injection Lanreotide Injection The metabolism of Abemaciclib can be decreased when combined with Lanreotide.
Nintedanib Nintedanib The metabolism of Abemaciclib can be decreased when combined with Nintedanib.
Secukinumab Injection Secukinumab Injection The metabolism of Abemaciclib can be increased when combined with Secukinumab.
Palbociclib Palbociclib The metabolism of Abemaciclib can be decreased when combined with Palbociclib.
Lenvatinib Lenvatinib The metabolism of Lenvatinib can be increased when combined with Abemaciclib.
Panobinostat Panobinostat The serum concentration of Abemaciclib can be increased when it is combined with Panobinostat.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Abemaciclib.
Isavuconazonium Injection Isavuconazonium Injection The metabolism of Abemaciclib can be increased when combined with Isavuconazonium.
Flibanserin Flibanserin The serum concentration of Abemaciclib can be increased when it is combined with Flibanserin.
Rolapitant Rolapitant The serum concentration of Abemaciclib can be increased when it is combined with Rolapitant.
Prednisolone Prednisolone The metabolism of Abemaciclib can be increased when combined with Prednisolone.
Daclatasvir Daclatasvir The serum concentration of Abemaciclib can be increased when it is combined with Daclatasvir.
Ziprasidone Injection Ziprasidone Injection The metabolism of Abemaciclib can be decreased when combined with Ziprasidone.
Cobimetinib Cobimetinib The metabolism of Abemaciclib can be decreased when combined with Cobimetinib.
Osimertinib Osimertinib The metabolism of Osimertinib can be increased when combined with Abemaciclib.
Alectinib Alectinib Alectinib may decrease the excretion rate of Abemaciclib which could result in a higher serum level.
Rifapentine Rifapentine The metabolism of Abemaciclib can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Abemaciclib can be increased when combined with Lesinurad.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The metabolism of Abemaciclib can be decreased when combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The metabolism of Abemaciclib can be increased when combined with Dexamethasone.
Venetoclax Venetoclax The metabolism of Abemaciclib can be decreased when combined with Venetoclax.
Cobicistat Cobicistat The metabolism of Abemaciclib can be decreased when combined with Cobicistat.
Selexipag Selexipag The serum concentration of Abemaciclib can be increased when it is combined with Selexipag.
Rucaparib Rucaparib The metabolism of Abemaciclib can be decreased when combined with Rucaparib.
Ribociclib Ribociclib The metabolism of Abemaciclib can be decreased when combined with Ribociclib.
Brigatinib Brigatinib The metabolism of Abemaciclib can be increased when combined with Brigatinib.
Deflazacort Deflazacort The metabolism of Abemaciclib can be increased when combined with Deflazacort.
Safinamide Safinamide Safinamide may decrease the excretion rate of Abemaciclib which could result in a higher serum level.
Sarilumab Injection Sarilumab Injection The metabolism of Abemaciclib can be increased when combined with Sarilumab.
Midostaurin Midostaurin The metabolism of Abemaciclib can be decreased when combined with Midostaurin.
Neratinib Neratinib The serum concentration of Abemaciclib can be increased when it is combined with Neratinib.
Enasidenib Enasidenib The metabolism of Enasidenib can be increased when combined with Abemaciclib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Abemaciclib can be increased when it is combined with Inotuzumab ozogamicin.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Abemaciclib can be increased when combined with Fosaprepitant.
Copanlisib Injection Copanlisib Injection Abemaciclib may decrease the excretion rate of Copanlisib which could result in a higher serum level.
Delafloxacin Delafloxacin Abemaciclib may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Betrixaban Betrixaban The serum concentration of Abemaciclib can be increased when it is combined with Betrixaban.
Acalabrutinib Acalabrutinib The metabolism of Abemaciclib can be decreased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Abemaciclib can be decreased when combined with Letermovir.
Ertugliflozin Ertugliflozin Abemaciclib may decrease the excretion rate of Ertugliflozin which could result in a higher serum level.
Buprenorphine Injection Buprenorphine Injection The metabolism of Abemaciclib can be decreased when combined with Buprenorphine.
Apalutamide Apalutamide The metabolism of Abemaciclib can be increased when combined with Apalutamide.
Fostamatinib Fostamatinib The metabolism of Abemaciclib can be decreased when combined with Fostamatinib.
Avatrombopag Avatrombopag Avatrombopag may decrease the excretion rate of Abemaciclib which could result in a higher serum level.
Baricitinib Baricitinib The excretion of Baricitinib can be decreased when combined with Abemaciclib.
Lofexidine Lofexidine The excretion of Abemaciclib can be decreased when combined with Lofexidine.
Plazomicin Injection Plazomicin Injection The excretion of Abemaciclib can be decreased when combined with Plazomicin.
Eliglustat Eliglustat The serum concentration of Abemaciclib can be increased when it is combined with Eliglustat.
Ivosidenib Ivosidenib The metabolism of Abemaciclib can be increased when combined with Ivosidenib.
Lusutrombopag Lusutrombopag Abemaciclib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Elagolix Elagolix The serum concentration of Abemaciclib can be increased when it is combined with Elagolix.
Tafenoquine Tafenoquine The excretion of Abemaciclib can be decreased when combined with Tafenoquine.
Cannabidiol Cannabidiol Cannabidiol may decrease the excretion rate of Abemaciclib which could result in a higher serum level.
Dacomitinib Dacomitinib The serum concentration of Abemaciclib can be increased when it is combined with Dacomitinib.
Duvelisib Duvelisib The metabolism of Duvelisib can be decreased when combined with Abemaciclib.
Omadacycline Omadacycline The serum concentration of Abemaciclib can be increased when it is combined with Omadacycline.
Sarecycline Sarecycline The serum concentration of Abemaciclib can be increased when it is combined with Sarecycline.
Stiripentol Stiripentol The metabolism of Abemaciclib can be decreased when combined with Stiripentol.
Talazoparib Talazoparib Abemaciclib may decrease the excretion rate of Talazoparib which could result in a higher serum level.
Gilteritinib Gilteritinib The excretion of Abemaciclib can be decreased when combined with Gilteritinib.
Glasdegib Glasdegib The serum concentration of Abemaciclib can be increased when it is combined with Glasdegib.
Larotrectinib Larotrectinib The serum concentration of Abemaciclib can be increased when it is combined with Larotrectinib.
Methoxy Polyethylene Glycol-Epoetin Beta Injection Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Abemaciclib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Abemaciclib can be increased when combined with Paclitaxel.
Rifamycin Rifamycin The metabolism of Abemaciclib can be increased when combined with Rifamycin.
Prucalopride Prucalopride The metabolism of Abemaciclib can be decreased when combined with Prucalopride.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Abemaciclib can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Abemaciclib can be decreased when combined with Siponimod.
Acyclovir Ophthalmic Acyclovir Ophthalmic The excretion of Abemaciclib can be decreased when combined with Acyclovir.
Erdafitinib Erdafitinib The serum concentration of Abemaciclib can be increased when it is combined with Erdafitinib.
Alpelisib Alpelisib The serum concentration of Alpelisib can be increased when it is combined with Abemaciclib.
Cladribine Cladribine Abemaciclib may decrease the excretion rate of Cladribine which could result in a higher serum level.
Solriamfetol Solriamfetol The excretion of Abemaciclib can be decreased when combined with Solriamfetol.
Darolutamide Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Abemaciclib.
Triclabendazole Triclabendazole The metabolism of Abemaciclib can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The serum concentration of Abemaciclib can be increased when it is combined with Entrectinib.
Pexidartinib Pexidartinib The excretion of Abemaciclib can be decreased when combined with Pexidartinib.
Istradefylline Istradefylline The serum concentration of Abemaciclib can be increased when it is combined with Istradefylline.
Pitolisant Pitolisant The serum concentration of Abemaciclib can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The serum concentration of Abemaciclib can be increased when it is combined with Fedratinib.
Lefamulin Lefamulin The serum concentration of Abemaciclib can be increased when it is combined with Lefamulin.
Phenytoin Injection Phenytoin Injection The metabolism of Abemaciclib can be increased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Abemaciclib can be increased when combined with Fosphenytoin.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Abemaciclib can be increased when it is combined with Enfortumab vedotin.
Voxelotor Voxelotor The serum concentration of Abemaciclib can be increased when it is combined with Voxelotor.
Lasmiditan Lasmiditan The serum concentration of Abemaciclib can be increased when it is combined with Lasmiditan.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Abemaciclib.
Tazemetostat Tazemetostat The excretion of Tazemetostat can be decreased when combined with Abemaciclib.
Cenobamate Cenobamate The serum concentration of Abemaciclib can be decreased when it is combined with Cenobamate.
Ozanimod Ozanimod Abemaciclib may decrease the excretion rate of Ozanimod which could result in a higher serum level.
Selumetinib Selumetinib Abemaciclib may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Rimegepant Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Abemaciclib.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Abemaciclib.
Remdesivir Injection Remdesivir Injection The excretion of Abemaciclib can be decreased when combined with Remdesivir.
Ripretinib Ripretinib The serum concentration of Ripretinib can be increased when it is combined with Abemaciclib.
Selpercatinib Selpercatinib The excretion of Abemaciclib can be decreased when combined with Selpercatinib.
Capmatinib Capmatinib The serum concentration of Abemaciclib can be increased when it is combined with Capmatinib.
Lemborexant Lemborexant The serum concentration of Abemaciclib can be increased when it is combined with Lemborexant.
Fostemsavir Fostemsavir Fostemsavir may decrease the excretion rate of Abemaciclib which could result in a higher serum level.
Octreotide Octreotide The serum concentration of Abemaciclib can be increased when it is combined with Octreotide.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Abemaciclib can be increased when it is combined with Belantamab mafodotin.
Pralsetinib Pralsetinib The metabolism of Pralsetinib can be increased when combined with Abemaciclib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Abemaciclib can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Abemaciclib can be decreased when combined with Drospirenone.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The metabolism of Abemaciclib can be increased when combined with Vitamin E.
Trazodone Trazodone The serum concentration of Abemaciclib can be decreased when it is combined with Trazodone.
Phenobarbital Phenobarbital The metabolism of Abemaciclib can be increased when combined with Phenobarbital.
Methotrexate Injection Methotrexate Injection Abemaciclib may decrease the excretion rate of Methotrexate which could result in a higher serum level.
Primidone Primidone The metabolism of Abemaciclib can be increased when combined with Primidone.
Chlorpromazine Chlorpromazine The metabolism of Abemaciclib can be increased when combined with Chlorpromazine.
Diazepam Diazepam The metabolism of Abemaciclib can be decreased when combined with Diazepam.
Lorazepam Lorazepam The metabolism of Abemaciclib can be decreased when combined with Lorazepam.
Bromocriptine Bromocriptine The metabolism of Abemaciclib can be decreased when combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Abemaciclib can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Abemaciclib can be decreased when combined with Phenelzine.
Tetracycline Tetracycline The metabolism of Abemaciclib can be decreased when combined with Tetracycline.
Prochlorperazine Prochlorperazine The metabolism of Abemaciclib can be decreased when combined with Prochlorperazine.
Methadone Methadone The metabolism of Abemaciclib can be increased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Abemaciclib can be decreased when combined with Oxybutynin.
Orphenadrine Orphenadrine The metabolism of Abemaciclib can be decreased when combined with Orphenadrine.
Phentermine Phentermine The metabolism of Abemaciclib can be decreased when combined with Phentermine.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the excretion rate of Abemaciclib which could result in a higher serum level.
Hydrocortisone Hydrocortisone The metabolism of Abemaciclib can be increased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The metabolism of Doxorubicin can be decreased when combined with Abemaciclib.
Dactinomycin Dactinomycin Abemaciclib may decrease the excretion rate of Dactinomycin which could result in a higher serum level.
Carbamazepine Carbamazepine The metabolism of Abemaciclib can be increased when combined with Carbamazepine.
Prazosin Prazosin Abemaciclib may decrease the excretion rate of Prazosin which could result in a higher serum level.
Hydralazine Hydralazine The metabolism of Abemaciclib can be decreased when combined with Hydralazine.
Cimetidine Cimetidine The metabolism of Abemaciclib can be decreased when combined with Cimetidine.
Warfarin Warfarin The metabolism of Abemaciclib can be increased when combined with Warfarin.
Loperamide Loperamide The metabolism of Abemaciclib can be decreased when combined with Loperamide.
Daunorubicin Daunorubicin The metabolism of Daunorubicin can be decreased when combined with Abemaciclib.
Nitrofurantoin Nitrofurantoin Abemaciclib may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Griseofulvin Griseofulvin The metabolism of Abemaciclib can be increased when combined with Griseofulvin.
Digoxin Digoxin The serum concentration of Abemaciclib can be increased when it is combined with Digoxin.
Loxapine Loxapine The serum concentration of Abemaciclib can be increased when it is combined with Loxapine.
Quinine Quinine The metabolism of Abemaciclib can be increased when combined with Quinine.
Calcitriol Calcitriol The metabolism of Abemaciclib can be increased when combined with Calcitriol.
Sulfinpyrazone Sulfinpyrazone The metabolism of Abemaciclib can be increased when combined with Sulfinpyrazone.
Secobarbital Secobarbital The metabolism of Abemaciclib can be increased when combined with Secobarbital.
Desipramine Desipramine The metabolism of Abemaciclib can be decreased when combined with Desipramine.
Probenecid Probenecid The metabolism of Abemaciclib can be increased when combined with Probenecid.
Quinidine Quinidine The metabolism of Abemaciclib can be decreased when combined with Quinidine.
Procainamide Procainamide The excretion of Procainamide can be decreased when combined with Abemaciclib.
Isoniazid Isoniazid The metabolism of Abemaciclib can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Abemaciclib can be increased when combined with Rifampicin.
Valproic Acid Valproic Acid The metabolism of Abemaciclib can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be increased when combined with Abemaciclib.
Levothyroxine Levothyroxine The serum concentration of Abemaciclib can be decreased when it is combined with Levothyroxine.
Methimazole Methimazole The metabolism of Abemaciclib can be decreased when combined with Methimazole.
Niacin Niacin The metabolism of Abemaciclib can be decreased when combined with Niacin.
Folic Acid Folic Acid Abemaciclib may decrease the excretion rate of Folic acid which could result in a higher serum level.
Danazol Danazol The metabolism of Abemaciclib can be decreased when combined with Danazol.
Amphotericin B Injection Amphotericin B Injection The metabolism of Abemaciclib can be decreased when combined with Amphotericin B.
Nadolol Nadolol The excretion of Nadolol can be decreased when combined with Abemaciclib.
Allopurinol Allopurinol Abemaciclib may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Clomiphene Clomiphene The serum concentration of Abemaciclib can be increased when it is combined with Clomifene.
Fluorouracil Injection Fluorouracil Injection Abemaciclib may decrease the excretion rate of Fluorouracil which could result in a higher serum level.
Colchicine Colchicine The metabolism of Abemaciclib can be increased when combined with Colchicine.
Cephalexin Cephalexin The excretion of Abemaciclib can be decreased when combined with Cephalexin.
Acetazolamide Acetazolamide The metabolism of Abemaciclib can be decreased when combined with Acetazolamide.
Ketoconazole Ketoconazole The metabolism of Abemaciclib can be decreased when combined with Ketoconazole.
Vincristine Injection Vincristine Injection Abemaciclib may decrease the excretion rate of Vincristine which could result in a higher serum level.
Vinblastine Vinblastine The metabolism of Abemaciclib can be increased when combined with Vinblastine.
Metoprolol Metoprolol The metabolism of Abemaciclib can be decreased when combined with Metoprolol.
Diltiazem Diltiazem The metabolism of Abemaciclib can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Abemaciclib can be increased when combined with Nifedipine.
Verapamil Verapamil The metabolism of Abemaciclib can be decreased when combined with Verapamil.
Etoposide Etoposide The metabolism of Etoposide can be increased when combined with Abemaciclib.
Glyburide Glyburide The metabolism of Glyburide can be decreased when combined with Abemaciclib.
Dicloxacillin Dicloxacillin The metabolism of Abemaciclib can be increased when combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The metabolism of Abemaciclib can be increased when combined with Nafcillin.
Pimozide Pimozide The metabolism of Abemaciclib can be decreased when combined with Pimozide.
Amiodarone Amiodarone The metabolism of Abemaciclib can be decreased when combined with Amiodarone.
Lovastatin Lovastatin The metabolism of Abemaciclib can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The metabolism of Abemaciclib can be decreased when combined with Ciprofloxacin.
Clozapine Clozapine The metabolism of Abemaciclib can be increased when combined with Clozapine.
Clarithromycin Clarithromycin The metabolism of Abemaciclib can be decreased when combined with Clarithromycin.
Felodipine Felodipine The metabolism of Abemaciclib can be decreased when combined with Felodipine.
Pravastatin Pravastatin Pravastatin may decrease the excretion rate of Abemaciclib which could result in a higher serum level.
Simvastatin Simvastatin The serum concentration of Abemaciclib can be increased when it is combined with Simvastatin.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Abemaciclib.
Teniposide Injection Teniposide Injection The metabolism of Teniposide can be decreased when combined with Abemaciclib.
Itraconazole Itraconazole The metabolism of Abemaciclib can be decreased when combined with Itraconazole.
Rifabutin Rifabutin The metabolism of Abemaciclib can be increased when combined with Rifabutin.
Bisoprolol Bisoprolol The serum concentration of Abemaciclib can be increased when it is combined with Bisoprolol.
Doxazosin Doxazosin The metabolism of Abemaciclib can be decreased when combined with Doxazosin.
Isradipine Isradipine The metabolism of Abemaciclib can be decreased when combined with Isradipine.
Omeprazole Omeprazole The metabolism of Abemaciclib can be increased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Abemaciclib can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Abemaciclib can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine Venlafaxine may increase the excretion rate of Abemaciclib which could result in a lower serum level and potentially a reduction in efficacy.
Famciclovir Famciclovir The metabolism of Abemaciclib can be decreased when combined with Famciclovir.
Fluvoxamine Fluvoxamine The metabolism of Abemaciclib can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The metabolism of Abemaciclib can be decreased when combined with Nefazodone.
Losartan Losartan The metabolism of Abemaciclib can be decreased when combined with Losartan.
Lansoprazole Lansoprazole The metabolism of Abemaciclib can be increased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Abemaciclib can be increased when combined with Ifosfamide.
Nicardipine Nicardipine The metabolism of Abemaciclib can be decreased when combined with Nicardipine.
Ticlopidine Ticlopidine The metabolism of Abemaciclib can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The metabolism of Saquinavir can be decreased when combined with Abemaciclib.
Metformin Metformin The excretion of Abemaciclib can be decreased when combined with Metformin.
Lamivudine Lamivudine Abemaciclib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Riluzole Riluzole Abemaciclib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Abemaciclib can be increased when it is combined with Gemcitabine.
Ritonavir Ritonavir The metabolism of Abemaciclib can be decreased when combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Abemaciclib can be decreased when combined with Docetaxel.
Zafirlukast Zafirlukast The metabolism of Abemaciclib can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine The metabolism of Abemaciclib can be decreased when combined with Mirtazapine.
Topiramate Topiramate The metabolism of Abemaciclib can be increased when combined with Topiramate.
Donepezil Donepezil Abemaciclib may decrease the excretion rate of Donepezil which could result in a higher serum level.
Nelfinavir Nelfinavir Nelfinavir may decrease the excretion rate of Abemaciclib which could result in a higher serum level.
Fexofenadine Fexofenadine The serum concentration of Abemaciclib can be increased when it is combined with Fexofenadine.
Azithromycin Azithromycin The metabolism of Abemaciclib can be decreased when combined with Azithromycin.
Carvedilol Carvedilol The serum concentration of Abemaciclib can be increased when it is combined with Carvedilol.
Bicalutamide Bicalutamide The metabolism of Abemaciclib can be decreased when combined with Bicalutamide.
Propafenone Propafenone The serum concentration of Abemaciclib can be increased when it is combined with Propafenone.
Raloxifene Raloxifene The metabolism of Raloxifene can be decreased when combined with Abemaciclib.
Irbesartan Irbesartan The metabolism of Abemaciclib can be decreased when combined with Irbesartan.
Paroxetine Paroxetine The metabolism of Abemaciclib can be decreased when combined with Paroxetine.
Citalopram Citalopram The metabolism of Abemaciclib can be decreased when combined with Citalopram.
Efavirenz Efavirenz The metabolism of Abemaciclib can be decreased when combined with Efavirenz.
Sildenafil Sildenafil The serum concentration of Abemaciclib can be increased when it is combined with Sildenafil.
Celecoxib Celecoxib Abemaciclib may decrease the excretion rate of Celecoxib which could result in a higher serum level.
Rabeprazole Rabeprazole The metabolism of Abemaciclib can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Abemaciclib can be increased when combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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