Zolmitriptan

Zolmitriptan is used to treat the symptoms of migraine headaches (severe throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound and light). Zolmitriptan is in a class of medications called selective serotonin receptor agonists. It works by narrowing blood vessels around the brain, stopping pain signals from being sent to the brain, and blocking the release of certain natural substances that cause pain, nausea, and other symptoms of migraine. Zolmitriptan does not prevent migraine attacks or reduce the number of headaches you have.

Zolmitriptan comes as a tablet and an orally disintegrating tablet (tablet that dissolves quickly in the mouth) to take by mouth. It is usually taken at the first sign of a migraine headache. If your symptoms improve after you take zolmitriptan but return after 2 hours or longer, you may take a second tablet. However, if your symptoms do not improve after you take zolmitriptan, do not take a second tablet without calling your doctor. Your doctor will tell you the maximum number of tablets or orally disintegrating tablets you may take in a 24-hour period. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take zolmitriptan exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

You may take your first dose of zolmitriptan in a doctor's office or other medical facility where you can be monitored for serious reactions.

If your doctor has prescribed a dose lower than 2.5 mg, you may use your fingers to break the 2.5-mg tablet on the line that divides it in half. However, you should not break or split the orally disintegrating tablet.

To take the orally disintegrating tablet, use dry hands to peel back the foil packaging. Immediately take out the tablet and place it on your tongue. The tablet will quickly dissolve and can be swallowed with saliva. No water is needed to swallow disintegrating tablets. Do not open the foil packaging or remove the orally disintegrating tablet until just before you are ready to take it.

Call your doctor if your headaches do not get better or occur more frequently after taking zolmitriptan.

If you take zolmitriptan more often or for longer than the recommended period of time, your headaches may get worse or may occur more frequently. You should not take zolmitriptan or any other headache medication for more than 10 days per month. Call your doctor if you need to take zolmitriptan to treat more than three headaches in a 1-month period.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking zolmitriptan,

• tell your doctor and pharmacist if you are allergic to zolmitriptan, any other medications, or any of the ingredients in zolmitriptan tablets or orally disintegrating tablets. Ask your pharmacist for a list of the ingredients.

• do not take zolmitriptan if you have taken any of the following medications in the past 24 hours: other selective serotonin receptor agonists such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), or sumatriptan (Imitrex, in Treximet); or ergot-type medications such as bromocriptine (Parlodel), cabergoline , dihydroergotamine (D.H.E. 45, Migranal), ergoloid mesylates (Hydergine), ergonovine (Ergotrate), ergotamine (Cafergot, Ergomar, Wigraine), methylergonovine (Methergine), methysergide (Sansert), and pergolide (Permax).

• do not take zolmitriptan if you are taking a monoamine oxidase A (MAO-A) inhibitor such as isocarboxazid (Marplan), phenelzine (Parnate), or tranylcypromine (Nardil) or if you have taken one of these medications in the past 2 weeks.

• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, or herbal products you are taking or plan to take. Be sure to mention any of the following: acetaminophen (Tylenol); antidepressants such as amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Adapin, Sinequan), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); aspirin and other nonsteroidal anti-inflammatory medications (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); cimetidine (Tagamet); oral contraceptives ('birth control pills'); propranolol (Inderal); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, in Symbyax), fluvoxamine (Luvox), paroxetine (Paxil), and sertraline (Zoloft); and selective serotonin/norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Pristiq), duloxetine (Cymbalta), sibutramine (Meridia), and venlafaxine (Effexor). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

• tell your doctor if you have or have ever had heart disease; a heart attack; angina (chest pain); irregular heartbeats; stroke or 'mini-stroke'; or circulation problems such as varicose veins, blood clots in the legs, Raynaud's disease (problems with blood flow to the fingers, toes, ears, and nose), or ischemic bowel disease (bloody diarrhea and stomach pain caused by decreased blood flow to the intestines). Your doctor may tell you not to take zolmitriptan.

• tell your doctor if you smoke or are overweight; if you have or have ever had high blood pressure, high cholesterol, diabetes, or liver or kidney disease; if you have gone through menopause (change of life); or if any family members have or have ever had heart disease or stroke.

• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you plan to be sexually active while you are taking this medication, talk to your doctor about effective methods of birth control. If you become pregnant while taking zolmitriptan, call your doctor.

• you should know that this medication may make you drowsy or dizzy. Do not drive a car or operate machinery until you know how zolmitriptan affects you.

• talk to your doctor about your headache symptoms to make sure they are caused by migraine. Zolmitriptan should not be used to treat certain types of migraine headaches (hemiplegic or basilar) or other types of headaches (such as cluster headaches).

• if you have phenylketonuria (PKU, an inherited condition in which a special diet must be followed to prevent damage to your brain that can cause severe intellectual disability), you should know that the orally disintegrating tablets contain aspartame that forms phenylalanine.

Unless your doctor tells you otherwise, continue your normal diet.

• Zolmitriptan may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • feeling warm or cold

  • drowsiness

  • dry mouth

  • nausea

  • heartburn

  • sweating

  • dizziness or faintness

• Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

  • pain, tightness, pressure, or heaviness in the chest, throat, neck, or jaw

  • slow or difficult speech

  • weakness or numbness of an arm or leg

  • fast, pounding, or irregular heartbeat

  • bloody diarrhea

  • sudden or severe stomach pain

  • paleness or blue color of the fingers and toes

  • shortness of breath

  • swelling of the eyes, face, lips, tongue, or throat

  • difficulty breathing or swallowing

  • hoarseness

  • rash

  • hives

  • pain, burning, or tingling in the hands or feet

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat, and moisture (not in the bathroom). Dispose of any orally disintegrating tablets that you removed from the blister pack but did not use immediately.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

• extreme drowsiness

Keep all appointments with your doctor. Your blood pressure should be checked regularly.

You should keep a headache diary by writing down when you have headaches and when you take zolmitriptan.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug	Interaction
Moxifloxacin	Moxifloxacin The metabolism of Zolmitriptan can be decreased when combined with Moxifloxacin.
Insulin Glargine (rDNA origin) Injection	Insulin Glargine (rDNA origin) Injection The metabolism of Zolmitriptan can be increased when combined with Insulin glargine.
Leflunomide	Leflunomide The serum concentration of Zolmitriptan can be decreased when it is combined with Leflunomide.
Nevirapine	Nevirapine The metabolism of Zolmitriptan can be decreased when combined with Nevirapine.
Dolasetron	Dolasetron The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Dolasetron.
Aminophylline	Aminophylline The metabolism of Aminophylline can be decreased when combined with Zolmitriptan.
Anagrelide	Anagrelide The metabolism of Zolmitriptan can be decreased when combined with Anagrelide.
Candesartan	Candesartan Zolmitriptan may decrease the antihypertensive activities of Candesartan.
Cilostazol	Cilostazol The metabolism of Cilostazol can be decreased when combined with Zolmitriptan.
Clopidogrel	Clopidogrel The metabolism of Clopidogrel can be decreased when combined with Zolmitriptan.
Diphenoxylate	Diphenoxylate The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Diphenoxylate.
Estrogen and Progestin (Oral Contraceptives)	Estrogen and Progestin (Oral Contraceptives) The metabolism of Zolmitriptan can be decreased when combined with Conjugated estrogens.
Guanfacine	Guanfacine The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Guanfacine.
Methylergonovine	Methylergonovine Methylergometrine may increase the vasoconstricting activities of Zolmitriptan.
Naratriptan	Naratriptan The risk or severity of vasospastic reactions can be increased when Zolmitriptan is combined with Naratriptan.
Olsalazine	Olsalazine The risk or severity of hypertension can be increased when Zolmitriptan is combined with Olsalazine.
Paregoric	Paregoric The risk or severity of adverse effects can be increased when Morphine is combined with Zolmitriptan.
Penbutolol	Penbutolol Zolmitriptan may decrease the antihypertensive activities of Acebutolol.
Pentazocine	Pentazocine The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Pentazocine.
Ranitidine	Ranitidine The metabolism of Zolmitriptan can be decreased when combined with Ranitidine.
Reserpine	Reserpine The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Reserpine.
Rizatriptan	Rizatriptan The risk or severity of vasospastic reactions can be increased when Zolmitriptan is combined with Rizatriptan.
Sumatriptan	Sumatriptan The risk or severity of vasospastic reactions can be increased when Zolmitriptan is combined with Sumatriptan.
Tizanidine	Tizanidine The metabolism of Tizanidine can be decreased when combined with Zolmitriptan.
Famotidine Injection	Famotidine Injection The metabolism of Zolmitriptan can be decreased when combined with Famotidine.
Hydromorphone Injection	Hydromorphone Injection The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Hydromorphone.
Interferon Beta-1b Injection	Interferon Beta-1b Injection The metabolism of Zolmitriptan can be decreased when combined with Interferon beta-1b.
Interferon Gamma-1b Injection	Interferon Gamma-1b Injection The metabolism of Zolmitriptan can be decreased when combined with Interferon gamma-1b.
Levofloxacin Injection	Levofloxacin Injection The metabolism of Zolmitriptan can be decreased when combined with Levofloxacin.
Meperidine Injection	Meperidine Injection The metabolism of Zolmitriptan can be increased when combined with Meperidine.
Metoclopramide Injection	Metoclopramide Injection The risk or severity of sedation can be increased when Zolmitriptan is combined with Metoclopramide.
Morphine Injection	Morphine Injection The risk or severity of adverse effects can be increased when Morphine is combined with Zolmitriptan.
Altretamine	Altretamine The metabolism of Zolmitriptan can be decreased when combined with Amphetamine.
Cyclosporine	Cyclosporine The risk or severity of hypertension can be increased when Cyclosporine is combined with Zolmitriptan.
Ondansetron	Ondansetron The metabolism of Zolmitriptan can be decreased when combined with Ondansetron.
Granisetron	Granisetron The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Granisetron.
Torsemide	Torsemide Zolmitriptan may decrease the antihypertensive activities of Torasemide.
Olanzapine	Olanzapine The metabolism of Olanzapine can be decreased when combined with Zolmitriptan.
Alosetron	Alosetron The metabolism of Zolmitriptan can be decreased when combined with Alosetron.
Entacapone	Entacapone The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Entacapone.
Eprosartan	Eprosartan Zolmitriptan may decrease the antihypertensive activities of Eprosartan.
Meloxicam	Meloxicam The risk or severity of hypertension can be increased when Zolmitriptan is combined with Meloxicam.
Oxcarbazepine	Oxcarbazepine The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Oxcarbazepine.
Telmisartan	Telmisartan Zolmitriptan may decrease the antihypertensive activities of Telmisartan.
Zaleplon	Zaleplon The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Zaleplon.
Anakinra	Anakinra The metabolism of Zolmitriptan can be increased when combined with Anakinra.
Desloratadine	Desloratadine The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Desloratadine.
Linezolid	Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Zolmitriptan.
Trimipramine	Trimipramine The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Trimipramine.
Etanercept Injection	Etanercept Injection The metabolism of Zolmitriptan can be increased when combined with Etanercept.
Glycopyrrolate	Glycopyrrolate Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
Modafinil	Modafinil The metabolism of Zolmitriptan can be increased when combined with Modafinil.
Perindopril	Perindopril Zolmitriptan may decrease the antihypertensive activities of Perindopril.
Choline Magnesium Trisalicylate	Choline Magnesium Trisalicylate The risk or severity of hypertension can be increased when Zolmitriptan is combined with Choline magnesium trisalicylate.
Dutasteride	Dutasteride The risk or severity of hypertension can be increased when Zolmitriptan is combined with Dutasteride.
Epinephrine Injection	Epinephrine Injection The risk or severity of hypertension can be increased when Zolmitriptan is combined with Epinephrine.
Eplerenone	Eplerenone Zolmitriptan may decrease the antihypertensive activities of Eplerenone.
Escitalopram	Escitalopram The risk or severity of serotonin syndrome can be increased when Zolmitriptan is combined with Escitalopram.
Olmesartan	Olmesartan Zolmitriptan may decrease the antihypertensive activities of Olmesartan.
Zonisamide	Zonisamide The metabolism of Zolmitriptan can be decreased when combined with Zonisamide.
Adalimumab Injection	Adalimumab Injection The metabolism of Zolmitriptan can be increased when combined with Adalimumab.
Aripiprazole	Aripiprazole The risk or severity of vasospastic reactions can be increased when Zolmitriptan is combined with Aripiprazole.
Atomoxetine	Atomoxetine The risk or severity of adverse effects can be increased when Atomoxetine is combined with Zolmitriptan.
Dexmethylphenidate	Dexmethylphenidate The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Dexmethylphenidate.
Almotriptan	Almotriptan The risk or severity of vasospastic reactions can be increased when Zolmitriptan is combined with Almotriptan.
Eletriptan	Eletriptan The risk or severity of vasospastic reactions can be increased when Eletriptan is combined with Zolmitriptan.
Interferon Beta-1a Subcutaneous Injection	Interferon Beta-1a Subcutaneous Injection The metabolism of Zolmitriptan can be decreased when combined with Interferon beta-1a.
Tegaserod	Tegaserod The metabolism of Zolmitriptan can be decreased when combined with Tegaserod.
Tadalafil	Tadalafil Zolmitriptan may decrease the antihypertensive activities of Tadalafil.
Frovatriptan	Frovatriptan The risk or severity of vasospastic reactions can be increased when Zolmitriptan is combined with Frovatriptan.
Gemifloxacin	Gemifloxacin The metabolism of Zolmitriptan can be decreased when combined with Gemifloxacin.
Apomorphine Injection	Apomorphine Injection The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Apomorphine.
Infliximab Injection	Infliximab Injection The metabolism of Zolmitriptan can be increased when combined with Infliximab.
Protriptyline	Protriptyline The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Protriptyline.
Duloxetine	Duloxetine The risk or severity of serotonin syndrome can be increased when Zolmitriptan is combined with Duloxetine.
Trospium	Trospium Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Bosentan	Bosentan Zolmitriptan may decrease the antihypertensive activities of Bosentan.
Cinacalcet	Cinacalcet The metabolism of Cinacalcet can be decreased when combined with Zolmitriptan.
Erlotinib	Erlotinib The metabolism of Erlotinib can be decreased when combined with Zolmitriptan.
Eszopiclone	Eszopiclone The risk or severity of CNS depression can be increased when Zolmitriptan is combined with Eszopiclone.
Solifenacin	Solifenacin Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Solifenacin.
Dextroamphetamine	Dextroamphetamine The metabolism of Zolmitriptan can be decreased when combined with Amphetamine.
Entecavir	Entecavir The metabolism of Entecavir can be decreased when combined with Zolmitriptan.
Peginterferon Alfa-2a Injection	Peginterferon Alfa-2a Injection The metabolism of Zolmitriptan can be decreased when combined with Peginterferon alfa-2a.
Peginterferon Alfa-2b (PEG-Intron)	Peginterferon Alfa-2b (PEG-Intron) The metabolism of Zolmitriptan can be decreased when combined with Peginterferon alfa-2b.
Sodium Oxybate	Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Zolmitriptan.
Isocarboxazid	Isocarboxazid The metabolism of Zolmitriptan can be decreased when combined with Isocarboxazid.
Ramelteon	Ramelteon The metabolism of Ramelteon can be decreased when combined with Zolmitriptan.
Darifenacin	Darifenacin Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Darifenacin.
Fentanyl	Fentanyl The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Fentanyl.
Pregabalin	Pregabalin The therapeutic efficacy of Zolmitriptan can be increased when used in combination with Pregabalin.
Deferasirox	Deferasirox The metabolism of Zolmitriptan can be decreased when combined with Deferasirox.
Phenylephrine	Phenylephrine The metabolism of Zolmitriptan can be increased when combined with Phenylephrine.
Felbamate	Felbamate The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Felbamate.
Abatacept Injection	Abatacept Injection The metabolism of Zolmitriptan can be increased when combined with Abatacept.
Rasagiline	Rasagiline The metabolism of Zolmitriptan can be decreased when combined with Rasagiline.
Imatinib	Imatinib The metabolism of Imatinib can be decreased when combined with Zolmitriptan.
Albuterol	Albuterol The risk or severity of hypertension can be increased when Zolmitriptan is combined with Salbutamol.
Paliperidone	Paliperidone The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Paliperidone.
Bortezomib	Bortezomib The metabolism of Zolmitriptan can be decreased when combined with Bortezomib.
Insulin Glulisine (rDNA origin) Injection	Insulin Glulisine (rDNA origin) Injection The metabolism of Zolmitriptan can be increased when combined with Insulin glulisine.
Primaquine	Primaquine The metabolism of Zolmitriptan can be increased when combined with Primaquine.
Aliskiren	Aliskiren Zolmitriptan may decrease the antihypertensive activities of Aliskiren.
Pemetrexed Injection	Pemetrexed Injection The metabolism of Pemetrexed can be decreased when combined with Zolmitriptan.
Dimenhydrinate	Dimenhydrinate The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Dimenhydrinate.
Lisdexamfetamine	Lisdexamfetamine The risk or severity of serotonin syndrome can be increased when Zolmitriptan is combined with Lisdexamfetamine.
Nabilone	Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Zolmitriptan.
Sorafenib	Sorafenib The metabolism of Sorafenib can be decreased when combined with Zolmitriptan.
Dronabinol	Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Zolmitriptan.
Levocetirizine	Levocetirizine The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Levocetirizine.
Dasatinib	Dasatinib The metabolism of Dasatinib can be decreased when combined with Zolmitriptan.
Mexiletine	Mexiletine The metabolism of Zolmitriptan can be decreased when combined with Mexiletine.
Armodafinil	Armodafinil The metabolism of Zolmitriptan can be increased when combined with Armodafinil.
Desmopressin	Desmopressin The risk or severity of hypertension can be increased when Desmopressin is combined with Zolmitriptan.
OnabotulinumtoxinA Injection	OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Zolmitriptan.
RimabotulinumtoxinB Injection	RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Botulinum Toxin Type B is combined with Zolmitriptan.
Desvenlafaxine	Desvenlafaxine The risk or severity of serotonin syndrome can be increased when Zolmitriptan is combined with Desvenlafaxine.
Nebivolol	Nebivolol Zolmitriptan may decrease the antihypertensive activities of Nebivolol.
Bendamustine Injection	Bendamustine Injection The metabolism of Bendamustine can be decreased when combined with Zolmitriptan.
Flecainide	Flecainide The metabolism of Flecainide can be decreased when combined with Zolmitriptan.
Certolizumab Injection	Certolizumab Injection The metabolism of Zolmitriptan can be increased when combined with Certolizumab pegol.
Praziquantel	Praziquantel The metabolism of Praziquantel can be decreased when combined with Zolmitriptan.
Rufinamide	Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Zolmitriptan.
Midazolam	Midazolam The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Midazolam.
Naltrexone Injection	Naltrexone Injection The risk or severity of serotonin syndrome can be increased when Zolmitriptan is combined with Naltrexone.
Eltrombopag	Eltrombopag The metabolism of Eltrombopag can be decreased when combined with Zolmitriptan.
Milnacipran	Milnacipran The risk or severity of serotonin syndrome can be increased when Zolmitriptan is combined with Milnacipran.
Fesoterodine	Fesoterodine Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine.
Betaxolol	Betaxolol The metabolism of Zolmitriptan can be decreased when combined with Betaxolol.
Iloperidone	Iloperidone The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Iloperidone.
Lacosamide	Lacosamide The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Lacosamide.
Dronedarone	Dronedarone The risk or severity of hypertension can be increased when Zolmitriptan is combined with Dronedarone.
AbobotulinumtoxinA Injection	AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Zolmitriptan.
Palonosetron Injection	Palonosetron Injection The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Palonosetron.
Tapentadol	Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Zolmitriptan.
Golimumab Injection	Golimumab Injection The metabolism of Zolmitriptan can be increased when combined with Golimumab.
Pazopanib	Pazopanib The metabolism of Pazopanib can be decreased when combined with Zolmitriptan.
Asenapine	Asenapine The metabolism of Asenapine can be decreased when combined with Zolmitriptan.
Vigabatrin	Vigabatrin The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Vigabatrin.
Albendazole	Albendazole The metabolism of Albendazole can be decreased when combined with Zolmitriptan.
Oxymorphone	Oxymorphone The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Oxymorphone.
Tocilizumab Injection	Tocilizumab Injection The metabolism of Zolmitriptan can be increased when combined with Tocilizumab.
IncobotulinumtoxinA Injection	IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Zolmitriptan.
Lurasidone	Lurasidone The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Lurasidone.
Acetaminophen Injection	Acetaminophen Injection The metabolism of Acetaminophen can be decreased when combined with Zolmitriptan.
Vilazodone	Vilazodone The risk or severity of vasospastic reactions can be increased when Zolmitriptan is combined with Vilazodone.
Terbutaline Injection	Terbutaline Injection The risk or severity of hypertension can be increased when Zolmitriptan is combined with Terbutaline.
Telaprevir	Telaprevir The metabolism of Zolmitriptan can be decreased when combined with Glecaprevir.
Abiraterone	Abiraterone The metabolism of Zolmitriptan can be decreased when combined with Abiraterone.
Clobazam	Clobazam The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Clobazam.
Vemurafenib	Vemurafenib The serum concentration of Zolmitriptan can be increased when it is combined with Vemurafenib.
Axitinib	Axitinib The metabolism of Axitinib can be decreased when combined with Zolmitriptan.
Cabergoline	Cabergoline The risk or severity of vasospastic reactions can be increased when Cabergoline is combined with Zolmitriptan.
Ambrisentan	Ambrisentan Zolmitriptan may decrease the antihypertensive activities of Ambrisentan.
Ezogabine	Ezogabine The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Tiagabine.
Mirabegron	Mirabegron The risk or severity of hypertension can be increased when Zolmitriptan is combined with Mirabegron.
Teriflunomide	Teriflunomide The serum concentration of Zolmitriptan can be decreased when it is combined with Teriflunomide.
Pomalidomide	Pomalidomide The metabolism of Pomalidomide can be decreased when combined with Zolmitriptan.
Levomilnacipran	Levomilnacipran The risk or severity of serotonin syndrome can be increased when Zolmitriptan is combined with Levomilnacipran.
Vortioxetine	Vortioxetine The risk or severity of vasospastic reactions can be increased when Zolmitriptan is combined with Vortioxetine.
Perampanel	Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Zolmitriptan.
Ketorolac Injection	Ketorolac Injection The risk or severity of hypertension can be increased when Zolmitriptan is combined with Ketorolac.
Simeprevir	Simeprevir The metabolism of Zolmitriptan can be decreased when combined with Simeprevir.
Dapagliflozin	Dapagliflozin The metabolism of Zolmitriptan can be decreased when combined with Dapagliflozin.
Apremilast	Apremilast The metabolism of Zolmitriptan can be increased when combined with Apremilast.
Droxidopa	Droxidopa Zolmitriptan may increase the hypertensive activities of Droxidopa.
Siltuximab Injection	Siltuximab Injection The metabolism of Zolmitriptan can be increased when combined with Siltuximab.
Eslicarbazepine	Eslicarbazepine The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Eslicarbazepine.
Belinostat Injection	Belinostat Injection The metabolism of Zolmitriptan can be increased when combined with Belinostat.
Hydrocodone	Hydrocodone Hydrocodone may increase the central nervous system depressant (CNS depressant) activities of Zolmitriptan.
Suvorexant	Suvorexant Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Peginterferon Beta-1a Injection	Peginterferon Beta-1a Injection The metabolism of Zolmitriptan can be decreased when combined with Peginterferon beta-1a.
Methamphetamine	Methamphetamine The metabolism of Zolmitriptan can be decreased when combined with Metamfetamine.
Tasimelteon	Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Zolmitriptan.
Riociguat	Riociguat Zolmitriptan may decrease the antihypertensive activities of Riociguat.
Pirfenidone	Pirfenidone The metabolism of Zolmitriptan can be decreased when combined with Pirfenidone.
Secukinumab Injection	Secukinumab Injection The metabolism of Zolmitriptan can be increased when combined with Secukinumab.
Risperidone Injection	Risperidone Injection The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Risperidone.
Insulin Human Inhalation	Insulin Human Inhalation The metabolism of Zolmitriptan can be increased when combined with Insulin human.
Lenvatinib	Lenvatinib The metabolism of Zolmitriptan can be decreased when combined with Lenvatinib.
Haloperidol Injection	Haloperidol Injection The risk or severity of CNS depression can be increased when Zolmitriptan is combined with Haloperidol.
Macitentan	Macitentan Zolmitriptan may decrease the antihypertensive activities of Macitentan.
Flibanserin	Flibanserin The risk or severity of vasospastic reactions can be increased when Zolmitriptan is combined with Flibanserin.
Brexpiprazole	Brexpiprazole The risk or severity of vasospastic reactions can be increased when Zolmitriptan is combined with Brexpiprazole.
Ziprasidone Injection	Ziprasidone Injection The risk or severity of vasospastic reactions can be increased when Zolmitriptan is combined with Ziprasidone.
Cariprazine	Cariprazine The risk or severity of vasospastic reactions can be increased when Zolmitriptan is combined with Cariprazine.
Eluxadoline	Eluxadoline The risk or severity of serotonin syndrome can be increased when Zolmitriptan is combined with Eluxadoline.
Insulin Degludec (rDNA Origin) Injection	Insulin Degludec (rDNA Origin) Injection The metabolism of Zolmitriptan can be increased when combined with Insulin degludec.
Osimertinib	Osimertinib The serum concentration of Zolmitriptan can be decreased when it is combined with Osimertinib.
Brivaracetam Injection	Brivaracetam Injection The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Brivaracetam.
Midodrine	Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Zolmitriptan.
Selexipag	Selexipag Zolmitriptan may decrease the antihypertensive activities of Selexipag.
Pimavanserin	Pimavanserin The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Pimavanserin.
Obeticholic Acid	Obeticholic Acid The metabolism of Zolmitriptan can be decreased when combined with Obeticholic acid.
Diphenhydramine Injection	Diphenhydramine Injection The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Diphenhydramine.
Furosemide Injection	Furosemide Injection Zolmitriptan may decrease the antihypertensive activities of Furosemide.
Rucaparib	Rucaparib The metabolism of Zolmitriptan can be decreased when combined with Rucaparib.
Doxepin (Insomnia)	Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Zolmitriptan.
Safinamide	Safinamide The metabolism of Zolmitriptan can be decreased when combined with Safinamide.
Midostaurin	Midostaurin The metabolism of Zolmitriptan can be decreased when combined with Midostaurin.
Enasidenib	Enasidenib The metabolism of Zolmitriptan can be decreased when combined with Enasidenib.
Buprenorphine Injection	Buprenorphine Injection Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Lofexidine	Lofexidine The therapeutic efficacy of Zolmitriptan can be increased when used in combination with Lofexidine.
Binimetinib	Binimetinib The metabolism of Binimetinib can be decreased when combined with Zolmitriptan.
Cannabidiol	Cannabidiol The risk or severity of vasospastic reactions can be increased when Cannabidiol is combined with Zolmitriptan.
Stiripentol	Stiripentol The metabolism of Zolmitriptan can be decreased when combined with Stiripentol.
Gilteritinib	Gilteritinib The therapeutic efficacy of Zolmitriptan can be decreased when used in combination with Gilteritinib.
Rifamycin	Rifamycin The metabolism of Zolmitriptan can be decreased when combined with Rifamycin.
Emapalumab-lzsg Injection	Emapalumab-lzsg Injection The metabolism of Zolmitriptan can be increased when combined with Emapalumab.
Siponimod	Siponimod The risk or severity of hypertension can be increased when Zolmitriptan is combined with Siponimod.
Acyclovir Ophthalmic	Acyclovir Ophthalmic The metabolism of Acyclovir can be decreased when combined with Zolmitriptan.
Brexanolone Injection	Brexanolone Injection The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Brexanolone.
Solriamfetol	Solriamfetol The risk or severity of hypertension can be increased when Solriamfetol is combined with Zolmitriptan.
Triclabendazole	Triclabendazole The metabolism of Zolmitriptan can be decreased when combined with Triclabendazole.
Istradefylline	Istradefylline The metabolism of Istradefylline can be decreased when combined with Zolmitriptan.
Pitolisant	Pitolisant The metabolism of Zolmitriptan can be increased when combined with Pitolisant.
Phenytoin Injection	Phenytoin Injection The risk or severity of adverse effects can be increased when Phenytoin is combined with Zolmitriptan.
Fosphenytoin Injection	Fosphenytoin Injection The metabolism of Zolmitriptan can be increased when combined with Fosphenytoin.
Lumateperone	Lumateperone The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Lumateperone.
Lasmiditan	Lasmiditan The risk or severity of serotonin syndrome can be increased when Zolmitriptan is combined with Lasmiditan.
Selumetinib	Selumetinib The metabolism of Selumetinib can be decreased when combined with Zolmitriptan.
Selpercatinib	Selpercatinib The risk or severity of hypertension can be increased when Zolmitriptan is combined with Selpercatinib.
Capmatinib	Capmatinib The metabolism of Zolmitriptan can be decreased when combined with Capmatinib.
Lemborexant	Lemborexant The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Lemborexant.
Fenfluramine	Fenfluramine The risk or severity of serotonin syndrome can be increased when Zolmitriptan is combined with Fenfluramine.
Satralizumab-mwge Injection	Satralizumab-mwge Injection The serum concentration of Zolmitriptan can be decreased when it is combined with Satralizumab.
Naxitamab-gqgk Injection	Naxitamab-gqgk Injection The risk or severity of hypertension can be increased when Zolmitriptan is combined with Naxitamab.
Viloxazine	Viloxazine The metabolism of Zolmitriptan can be decreased when combined with Viloxazine.
Theophylline	Theophylline The metabolism of Zolmitriptan can be decreased when combined with Theophylline.
Fenoprofen	Fenoprofen The risk or severity of hypertension can be increased when Zolmitriptan is combined with Fenoprofen.
Indomethacin	Indomethacin The risk or severity of hypertension can be increased when Zolmitriptan is combined with Indomethacin.
Mefenamic Acid	Mefenamic Acid The risk or severity of hypertension can be increased when Zolmitriptan is combined with Mefenamic acid.
Naproxen	Naproxen The metabolism of Naproxen can be decreased when combined with Zolmitriptan.
Tolmetin	Tolmetin The risk or severity of hypertension can be increased when Zolmitriptan is combined with Tolmetin.
Sulindac	Sulindac The risk or severity of hypertension can be increased when Zolmitriptan is combined with Sulindac.
Trazodone	Trazodone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Zolmitriptan.
Phenobarbital	Phenobarbital The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Phenobarbital.
Metaxalone	Metaxalone The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Metaxalone.
Levorphanol	Levorphanol The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Levorphanol.
Primidone	Primidone The metabolism of Zolmitriptan can be increased when combined with Primidone.
Methsuximide	Methsuximide The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Methsuximide.
Diethylpropion	Diethylpropion The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Diethylpropion.
Chlorpromazine	Chlorpromazine The metabolism of Chlorpromazine can be decreased when combined with Zolmitriptan.
Diazepam	Diazepam The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Diazepam.
Oxazepam	Oxazepam The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Oxazepam.
Flurazepam	Flurazepam The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Flurazepam.
Clorazepate	Clorazepate The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Clorazepic acid.
Lorazepam	Lorazepam The risk or severity of adverse effects can be increased when Lorazepam is combined with Zolmitriptan.
Phenoxybenzamine	Phenoxybenzamine The risk or severity of hypertension can be increased when Zolmitriptan is combined with Phenoxybenzamine.
Carmustine	Carmustine The metabolism of Zolmitriptan can be decreased when combined with Carmustine.
Amantadine	Amantadine The risk or severity of serotonin syndrome can be increased when Zolmitriptan is combined with Amantadine.
Codeine	Codeine The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Codeine.
Meprobamate	Meprobamate The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Meprobamate.
Chlordiazepoxide	Chlordiazepoxide The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Chlordiazepoxide.
Bromocriptine	Bromocriptine Bromocriptine may increase the vasoconstricting activities of Zolmitriptan.
Metaproterenol	Metaproterenol The risk or severity of hypertension can be increased when Zolmitriptan is combined with Orciprenaline.
Tranylcypromine	Tranylcypromine The metabolism of Zolmitriptan can be decreased when combined with Tranylcypromine.
Phenelzine	Phenelzine The metabolism of Zolmitriptan can be decreased when combined with Phenelzine.
Procarbazine	Procarbazine The metabolism of Zolmitriptan can be decreased when combined with Procarbazine.
Ergoloid Mesylates	Ergoloid Mesylates Ergoloid mesylate may increase the vasoconstricting activities of Zolmitriptan.
Minocycline	Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Zolmitriptan.
Prochlorperazine	Prochlorperazine The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Prochlorperazine.
Thioridazine	Thioridazine The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Thioridazine.
Trifluoperazine	Trifluoperazine The metabolism of Trifluoperazine can be decreased when combined with Zolmitriptan.
Oxycodone	Oxycodone The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Oxycodone.
Methadone	Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Zolmitriptan.
Oxybutynin	Oxybutynin Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Oxybutynin.
Benztropine	Benztropine Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Benzatropine.
Maprotiline	Maprotiline The metabolism of Maprotiline can be decreased when combined with Zolmitriptan.
Ibuprofen	Ibuprofen The risk or severity of hypertension can be increased when Zolmitriptan is combined with Ibuprofen.
Trihexyphenidyl	Trihexyphenidyl Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine	Orphenadrine The metabolism of Zolmitriptan can be decreased when combined with Orphenadrine.
Perphenazine	Perphenazine The metabolism of Perphenazine can be decreased when combined with Zolmitriptan.
Azathioprine	Azathioprine The metabolism of Azathioprine can be decreased when combined with Zolmitriptan.
Fluphenazine	Fluphenazine The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Fluphenazine.
Phentermine	Phentermine The metabolism of Zolmitriptan can be decreased when combined with Phentermine.
Methylphenidate	Methylphenidate The risk or severity of hypertension can be increased when Zolmitriptan is combined with Methylphenidate.
Amoxapine	Amoxapine The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Amoxapine.
Sulfasalazine	Sulfasalazine The risk or severity of hypertension can be increased when Zolmitriptan is combined with Sulfasalazine.
Carbamazepine	Carbamazepine The metabolism of Zolmitriptan can be decreased when combined with Carbamazepine.
Molindone	Molindone The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Molindone.
Methyldopa	Methyldopa Zolmitriptan may decrease the antihypertensive activities of Methyldopa.
Clonidine	Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Zolmitriptan.
Prazosin	Prazosin Zolmitriptan may decrease the antihypertensive activities of Prazosin.
Hydralazine	Hydralazine Zolmitriptan may decrease the antihypertensive activities of Hydralazine.
Cimetidine	Cimetidine The serum concentration of Zolmitriptan can be increased when it is combined with Cimetidine.
Warfarin	Warfarin The metabolism of Warfarin can be decreased when combined with Zolmitriptan.
Clonazepam	Clonazepam The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Clonazepam.
Promethazine	Promethazine The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Promethazine.
Meclofenamate	Meclofenamate The risk or severity of hypertension can be increased when Zolmitriptan is combined with Meclofenamic acid.
Griseofulvin	Griseofulvin The metabolism of Zolmitriptan can be increased when combined with Griseofulvin.
Loxapine	Loxapine The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Loxapine.
Quinine	Quinine The metabolism of Quinine can be decreased when combined with Zolmitriptan.
Ethosuximide	Ethosuximide The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Ethosuximide.
Triamterene	Triamterene The metabolism of Triamterene can be decreased when combined with Zolmitriptan.
Chlorothiazide	Chlorothiazide Zolmitriptan may decrease the antihypertensive activities of Chlorothiazide.
Chlorthalidone	Chlorthalidone Zolmitriptan may decrease the antihypertensive activities of Chlorthalidone.
Metolazone	Metolazone Zolmitriptan may decrease the antihypertensive activities of Metolazone.
Secobarbital	Secobarbital The metabolism of Zolmitriptan can be increased when combined with Secobarbital.
Desipramine	Desipramine Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Amitriptyline	Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Zolmitriptan.
Imipramine	Imipramine The metabolism of Zolmitriptan can be decreased when combined with Imipramine.
Quinidine	Quinidine The metabolism of Zolmitriptan can be decreased when combined with Quinidine.
Isoniazid	Isoniazid The metabolism of Zolmitriptan can be decreased when combined with Isoniazid.
Rifampin	Rifampin The metabolism of Zolmitriptan can be increased when combined with Rifampicin.
Disopyramide	Disopyramide The metabolism of Zolmitriptan can be decreased when combined with Disopyramide.
Valproic Acid	Valproic Acid The metabolism of Zolmitriptan can be decreased when combined with Valproic acid.
Tamoxifen	Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Zolmitriptan.
Butabarbital	Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Zolmitriptan.
Methimazole	Methimazole The metabolism of Zolmitriptan can be decreased when combined with Methimazole.
Dextromethorphan	Dextromethorphan The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Dextromethorphan.
Cyclobenzaprine	Cyclobenzaprine The risk or severity of CNS depression can be increased when Zolmitriptan is combined with Cyclobenzaprine.
Baclofen	Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Zolmitriptan.
Doxylamine	Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Zolmitriptan.
Cyproheptadine	Cyproheptadine The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Cyproheptadine.
Clemastine	Clemastine The risk or severity of adverse effects can be increased when Clemastine is combined with Zolmitriptan.
Chlorpheniramine	Chlorpheniramine The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Chlorpheniramine.
Brompheniramine	Brompheniramine The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Dexbrompheniramine.
Meclizine	Meclizine The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Meclizine.
Hydrochlorothiazide	Hydrochlorothiazide Zolmitriptan may decrease the antihypertensive activities of Hydrochlorothiazide.
Dantrolene	Dantrolene The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Dantrolene.
Chlorzoxazone	Chlorzoxazone The metabolism of Chlorzoxazone can be decreased when combined with Zolmitriptan.
Carisoprodol	Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Zolmitriptan.
Methocarbamol	Methocarbamol The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Methocarbamol.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) The serum concentration of the active metabolites of Zolmitriptan can be reduced when Zolmitriptan is used in combination with Propranolol resulting in a loss in efficacy.
Minoxidil	Minoxidil Zolmitriptan may decrease the antihypertensive activities of Minoxidil.
Pseudoephedrine	Pseudoephedrine The metabolism of Zolmitriptan can be decreased when combined with Pseudoephedrine.
Nortriptyline	Nortriptyline Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Nortriptyline.
Nadolol	Nadolol Zolmitriptan may decrease the antihypertensive activities of Nadolol.
Butorphanol Injection	Butorphanol Injection The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Butorphanol.
Nalbuphine Injection	Nalbuphine Injection The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Nalbuphine.
Trimethobenzamide	Trimethobenzamide The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Trimethobenzamide.
Flavoxate	Flavoxate Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
Fluorouracil Injection	Fluorouracil Injection The metabolism of Fluorouracil can be decreased when combined with Zolmitriptan.
Dacarbazine	Dacarbazine The metabolism of Dacarbazine can be decreased when combined with Zolmitriptan.
Acetazolamide	Acetazolamide The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Acetazolamide.
Ketoconazole	Ketoconazole The metabolism of Zolmitriptan can be decreased when combined with Ketoconazole.
Pyrantel	Pyrantel The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Pyrantel.
Captopril	Captopril Zolmitriptan may decrease the antihypertensive activities of Captopril.
Isoxsuprine	Isoxsuprine The risk or severity of hypertension can be increased when Zolmitriptan is combined with Isoxsuprine.
Metoprolol	Metoprolol Zolmitriptan may decrease the antihypertensive activities of Metoprolol.
Hydroxyzine	Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Zolmitriptan.
Thiothixene	Thiothixene The metabolism of Thiothixene can be decreased when combined with Zolmitriptan.
Aspirin	Aspirin The risk or severity of hypertension can be increased when Zolmitriptan is combined with Acetylsalicylic acid.
Salsalate	Salsalate The risk or severity of hypertension can be increased when Zolmitriptan is combined with Salsalate.
Alprazolam	Alprazolam The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Alprazolam.
Temazepam	Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Zolmitriptan.
Triazolam	Triazolam The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Triazolam.
Dicyclomine	Dicyclomine Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
Hyoscyamine	Hyoscyamine Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
Propantheline	Propantheline Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
Diltiazem	Diltiazem Zolmitriptan may decrease the antihypertensive activities of Diltiazem.
Nifedipine	Nifedipine The metabolism of Nifedipine can be decreased when combined with Zolmitriptan.
Timolol	Timolol Zolmitriptan may decrease the antihypertensive activities of Timolol.
Verapamil	Verapamil The metabolism of Verapamil can be decreased when combined with Zolmitriptan.
Atenolol	Atenolol Zolmitriptan may decrease the antihypertensive activities of Atenolol.
Pindolol	Pindolol The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Pindolol.
Diflunisal	Diflunisal The risk or severity of hypertension can be increased when Zolmitriptan is combined with Diflunisal.
Piroxicam	Piroxicam The risk or severity of hypertension can be increased when Zolmitriptan is combined with Piroxicam.
Streptozocin	Streptozocin The metabolism of Zolmitriptan can be increased when combined with Streptozocin.
Etoposide	Etoposide The metabolism of Etoposide can be decreased when combined with Zolmitriptan.
Indapamide	Indapamide Zolmitriptan may decrease the antihypertensive activities of Indapamide.
Nafcillin Injection	Nafcillin Injection The metabolism of Zolmitriptan can be increased when combined with Nafcillin.
Pentoxifylline	Pentoxifylline The metabolism of Pentoxifylline can be decreased when combined with Zolmitriptan.
Labetalol	Labetalol Zolmitriptan may decrease the antihypertensive activities of Labetalol.
Gemfibrozil	Gemfibrozil The metabolism of Zolmitriptan can be decreased when combined with Gemfibrozil.
Guanabenz	Guanabenz The metabolism of Guanabenz can be decreased when combined with Zolmitriptan.
Ketoprofen	Ketoprofen The risk or severity of hypertension can be increased when Zolmitriptan is combined with Ketoprofen.
Pimozide	Pimozide The metabolism of Pimozide can be decreased when combined with Zolmitriptan.
Enalapril	Enalapril Zolmitriptan may decrease the antihypertensive activities of Enalapril.
Flurbiprofen	Flurbiprofen The risk or severity of hypertension can be increased when Zolmitriptan is combined with Flurbiprofen.
Amiodarone	Amiodarone The metabolism of Zolmitriptan can be decreased when combined with Amiodarone.
Buspirone	Buspirone The risk or severity of serotonin syndrome can be increased when Zolmitriptan is combined with Buspirone.
Ciprofloxacin	Ciprofloxacin The metabolism of Zolmitriptan can be decreased when combined with Ciprofloxacin.
Mesalamine	Mesalamine The risk or severity of hypertension can be increased when Mesalazine is combined with Zolmitriptan.
Diclofenac	Diclofenac The metabolism of Diclofenac can be decreased when combined with Zolmitriptan.
Fluoxetine	Fluoxetine The risk or severity of serotonin syndrome can be increased when Zolmitriptan is combined with Fluoxetine.
Nimodipine	Nimodipine Zolmitriptan may decrease the antihypertensive activities of Nimodipine.
Interferon Alfa-2b Injection	Interferon Alfa-2b Injection The metabolism of Zolmitriptan can be decreased when combined with Interferon alfa-2b.
Clozapine	Clozapine The metabolism of Zolmitriptan can be decreased when combined with Clozapine.
Estazolam	Estazolam The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Estazolam.
Ofloxacin	Ofloxacin The metabolism of Zolmitriptan can be decreased when combined with Ofloxacin.
Benazepril	Benazepril Zolmitriptan may decrease the antihypertensive activities of Benazepril.
Etodolac	Etodolac The risk or severity of hypertension can be increased when Zolmitriptan is combined with Etodolac.
Felodipine	Felodipine Zolmitriptan may decrease the antihypertensive activities of Felodipine.
Fosinopril	Fosinopril Zolmitriptan may decrease the antihypertensive activities of Fosinopril.
Nabumetone	Nabumetone The metabolism of Nabumetone can be decreased when combined with Zolmitriptan.
Quinapril	Quinapril Zolmitriptan may decrease the antihypertensive activities of Quinapril.
Ramipril	Ramipril Zolmitriptan may decrease the antihypertensive activities of Ramipril.
Amlodipine	Amlodipine Zolmitriptan may decrease the antihypertensive activities of Amlodipine.
Lisinopril	Lisinopril Zolmitriptan may decrease the antihypertensive activities of Lisinopril.
Oxaprozin	Oxaprozin The risk or severity of hypertension can be increased when Zolmitriptan is combined with Oxaprozin.
Bisoprolol	Bisoprolol Zolmitriptan may decrease the antihypertensive activities of Bisoprolol.
Zolpidem	Zolpidem Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin	Doxazosin Zolmitriptan may decrease the antihypertensive activities of Doxazosin.
Terazosin	Terazosin Zolmitriptan may decrease the antihypertensive activities of Terazosin.
Isradipine	Isradipine Zolmitriptan may decrease the antihypertensive activities of Isradipine.
Omeprazole	Omeprazole The metabolism of Zolmitriptan can be decreased when combined with Omeprazole.
Cisapride	Cisapride The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Cisapride.
Gabapentin	Gabapentin The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Gabapentin.
Venlafaxine	Venlafaxine The risk or severity of serotonin syndrome can be increased when Venlafaxine is combined with Zolmitriptan.
Fluvoxamine	Fluvoxamine The risk or severity of serotonin syndrome can be increased when Fluvoxamine is combined with Zolmitriptan.
Nefazodone	Nefazodone The risk or severity of serotonin syndrome can be increased when Zolmitriptan is combined with Nefazodone.
Lamotrigine	Lamotrigine The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Lamotrigine.
Losartan	Losartan Zolmitriptan may decrease the antihypertensive activities of Losartan.
Tramadol	Tramadol The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Zolmitriptan.
Moexipril	Moexipril Zolmitriptan may decrease the antihypertensive activities of Moexipril.
Nicardipine	Nicardipine Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Nicardipine.
Bupropion	Bupropion The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Bupropion.
Ticlopidine	Ticlopidine The metabolism of Zolmitriptan can be decreased when combined with Ticlopidine.
Nisoldipine	Nisoldipine Zolmitriptan may decrease the antihypertensive activities of Nisoldipine.
Riluzole	Riluzole The metabolism of Riluzole can be decreased when combined with Zolmitriptan.
Ritonavir	Ritonavir The metabolism of Zolmitriptan can be increased when combined with Ritonavir.
Clomipramine	Clomipramine The metabolism of Clomipramine can be decreased when combined with Zolmitriptan.
Zafirlukast	Zafirlukast The metabolism of Zolmitriptan can be decreased when combined with Zafirlukast.
Mirtazapine	Mirtazapine Zolmitriptan may increase the serotonergic activities of Mirtazapine.
Trandolapril	Trandolapril Zolmitriptan may decrease the antihypertensive activities of Trandolapril.
Topiramate	Topiramate The risk or severity of adverse effects can be increased when Topiramate is combined with Zolmitriptan.
Zileuton	Zileuton The metabolism of Zileuton can be decreased when combined with Zolmitriptan.
Valsartan	Valsartan Zolmitriptan may decrease the antihypertensive activities of Valsartan.
Insulin Lispro Injection	Insulin Lispro Injection The metabolism of Zolmitriptan can be increased when combined with Insulin lispro.
Pramipexole	Pramipexole Zolmitriptan may increase the sedative activities of Pramipexole.
Donepezil	Donepezil The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Donepezil.
Carvedilol	Carvedilol The metabolism of Carvedilol can be decreased when combined with Zolmitriptan.
Flutamide	Flutamide The metabolism of Flutamide can be decreased when combined with Zolmitriptan.
Selegiline	Selegiline The metabolism of Zolmitriptan can be decreased when combined with Selegiline.
Sertraline	Sertraline The risk or severity of serotonin syndrome can be increased when Zolmitriptan is combined with Sertraline.
Propafenone	Propafenone The metabolism of Zolmitriptan can be decreased when combined with Propafenone.
Irbesartan	Irbesartan Zolmitriptan may decrease the antihypertensive activities of Irbesartan.
Ropinirole	Ropinirole Zolmitriptan may increase the sedative activities of Ropinirole.
Finasteride	Finasteride The risk or severity of hypertension can be increased when Zolmitriptan is combined with Finasteride.
Quetiapine	Quetiapine The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Quetiapine.
Cetirizine	Cetirizine The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Cetirizine.
Paroxetine	Paroxetine The risk or severity of serotonin syndrome can be increased when Paroxetine is combined with Zolmitriptan.
Tolcapone	Tolcapone The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Tolcapone.
Citalopram	Citalopram The risk or severity of serotonin syndrome can be increased when Citalopram is combined with Zolmitriptan.
Efavirenz	Efavirenz The metabolism of Zolmitriptan can be decreased when combined with Efavirenz.
Celecoxib	Celecoxib The risk or severity of hypertension can be increased when Zolmitriptan is combined with Celecoxib.
Rosiglitazone	Rosiglitazone The metabolism of Zolmitriptan can be decreased when combined with Rosiglitazone.
Tolterodine	Tolterodine Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Tolterodine.
Thalidomide	Thalidomide Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Balsalazide	Balsalazide The risk or severity of hypertension can be increased when Zolmitriptan is combined with Balsalazide.
Levetiracetam	Levetiracetam The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Levetiracetam.
Rabeprazole	Rabeprazole The metabolism of Zolmitriptan can be increased when combined with Rabeprazole.
Terbinafine	Terbinafine The metabolism of Terbinafine can be decreased when combined with Zolmitriptan.