Trazodone

Trazodone is used to treat depression. Trazodone is in a class of medications called serotonin modulators. It works by increasing the amount of serotonin, a natural substance in the brain that helps maintain mental balance.

Trazodone comes as a tablet to take by mouth. The tablet is usually taken with a meal or light snack two or more times a day. To help you remember to take trazodone, take it around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take trazodone exactly as directed. Do not take more or less of it, take it more often, or take it for a longer time than prescribed by your doctor.

Swallow the tablets whole or broken in half on the score mark.

Your doctor may start you on a low dose of trazodone and gradually increase your dose, not more than once every 3 to 4 days. Your doctor may decrease your dose once your condition is controlled.

Trazodone controls depression, but does not cure it. It may take 2 weeks or longer before you feel the full benefit of trazodone. Continue to take trazodone even if you feel well.

Do not stop taking trazodone without talking to your doctor. If you suddenly stop taking trazodone, you may experience withdrawal symptoms such as dizziness; nausea; headache; confusion; anxiety; agitation; difficulty falling asleep or staying asleep; extreme tiredness; seizures; pain, burning, or tingling in the hands or feet; frenzied or abnormally excited mood; ringing in the ears; or sweating. Your doctor will probably decrease your dose gradually.

Trazodone is also sometimes used to treat insomnia and schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions); anxiety (excessive worry). Trazodone is also sometimes used to control abnormal, uncontrollable movements that may be experienced as side effects of other medications and for the management of alcohol dependence. Talk to your doctor about the possible risks of using this medication for your condition.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Before taking trazodone,

• tell your doctor and pharmacist if you are allergic to trazodone or any other medications.

• tell your doctor if you are taking a monoamine oxidase (MAO) inhibitor, such as isocarboxazid (Marplan), linezolid, methylene blue, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), or if you have stopped taking one of these medications within the past 14 days. Your doctor will probably tell you that you should not take trazodone. If you stop taking trazodone, your doctor will tell you that you should wait at least 14 days before you start to take an MAO inhibitor.

• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: amiodarone (Nexterone, Pacerone); anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); antifungals such as itraconazole (Sporanox, Tolsura), ketoconazole, or voriconazole (Vfend); aspirin and other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); buspirone; carbamazepine (Carbatrol, Equetro, Tegretol, others); chlorpromazine; clarithromycin (Biaxin); clopidogrel (Plavix); dabigatran (Pradaxa); digoxin (Lanoxin); disopyramide (Norpace); diuretics ('water pills'); fentanyl (Actiq, Duragesic, Fentora, Subsys); indinavir (Crixivan); lithium (Lithobid); medications for anxiety, irregular heartbeat, mental illness or pain; medications for migraine headaches such as almotriptan, eletriptan (Relpax), frovatriptan (Frova), naratriptan, rizatriptan (Maxalt), and sumatriptan (Imitrex); phenobarbital; phenytoin (Dilantin, Phenytek); procainamide; quinidine (in Nuedexta); rifampin (Rifadin, Rimactane); rivaroxaban (Xarelto);sedatives; selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac), fluvoxamine (Luvox), paroxetine (Paxil, Pexeva), and sertraline (Zoloft); tranquilizers; sotalol (Betapace, Sorine, Sotylize); thioridazine; tramadol (Conzip, Qdola, Ultram, in Ultracet); tricyclic antidepressants such as amitriptyline, amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline, and trimipramine; or ziprasidone (Geodon). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with trazodone, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

• tell your doctor what herbal products and nutritional supplements you are taking, especially St. John's wort and tryptophan.

• tell your doctor if you or anyone in your family has or has ever had long QT syndrome (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death), if you have ever had a heart attack, or if you have a low level of sodium in your blood. Also tell your doctor if you drink or have ever drunk large amounts of alcohol, or if you have or have ever had high blood pressure; bleeding problems; sickle cell anemia (a disease of the red blood cells); multiple myeloma (cancer of the plasma cells); leukemia (cancer of the white blood cells); cavernosal fibrosis or Peyronie's disease (conditions that affects the shape of the penis such as angulation); or heart, liver, or kidney disease.

• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking trazodone, call your doctor.

• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking trazodone.

• you should know that trazodone may make you drowsy and affect your judgment, thinking, and movements. Do not drive a car or operate machinery until you know how this medication affects you.

• ask your doctor about the safe use of alcoholic beverages while you are taking trazodone. Alcohol can make the side effects from trazodone worse.

• you should know that trazodone may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

• you should know that trazodone may cause angle-closure glaucoma (a condition where the fluid is suddenly blocked and unable to flow out of the eye causing a quick, severe increase in eye pressure which may lead to a loss of vision). Talk to your doctor about having an eye examination before you start taking this medication. If you have nausea, eye pain, changes in vision, such as seeing colored rings around lights, and swelling or redness in or around the eye, call your doctor or get emergency medical treatment right away.

Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

• Trazodone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea

  • vomiting

  • diarrhea

  • constipation

  • changes in appetite or weight

  • weakness or tiredness

  • nervousness

  • dizziness or lightheadedness

  • nightmares

  • muscle pain

  • dry mouth

  • rash

  • sexual problems in males; decreased sex drive, inability to get or keep an erection, or delayed or absent ejaculation

  • sexual problems in females; decreased sex drive, or delayed orgasm or unable to have an orgasm

  • uncontrollable shaking of a part of the body

  • stuffy nose

  • tired, red, or itchy eyes

• Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS sections, call your doctor immediately or get emergency medical treatment:

  • chest pain

  • fast, pounding, or irregular heartbeat

  • loss of consciousness (coma)

  • fever, sweating, confusion, fast or irregular heartbeat, and severe muscle stiffness or twitching, agitation, hallucinations, loss of coordination, nausea, vomiting, or diarrhea

  • fainting

  • seizures

  • shortness of breath

  • unusual bruising or bleeding

  • nosebleeds

  • small red or purple dots on the skin

  • erection lasting more than 6 hours

  • headache

  • problems with thinking, concentration, or memory

  • weakness

  • problems with coordination

• Trazodone can cause painful, long lasting erections in males. In some cases emergency and/or surgical treatment has been required and, in some of these cases, permanent damage has occurred. Talk to your doctor about the risk of taking trazodone.

• Trazodone may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat, and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

• vomiting

• drowsiness

• changes in heartbeat

• seizures

• difficulty breathing

• painful erection that does not go away

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug	Interaction
Moxifloxacin	Moxifloxacin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Moxifloxacin.
Delavirdine	Delavirdine The serum concentration of Trazodone can be increased when it is combined with Delavirdine.
Nevirapine	Nevirapine The metabolism of Trazodone can be decreased when combined with Nevirapine.
Atorvastatin	Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Trazodone.
Dolasetron	Dolasetron The risk or severity of QTc prolongation can be increased when Trazodone is combined with Dolasetron.
Anagrelide	Anagrelide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Anagrelide.
Candesartan	Candesartan Trazodone may decrease the antihypertensive activities of Candesartan.
Cilostazol	Cilostazol The risk or severity of QTc prolongation can be increased when Trazodone is combined with Cilostazol.
Clopidogrel	Clopidogrel The risk or severity of bleeding can be increased when Trazodone is combined with Clopidogrel.
Diphenoxylate	Diphenoxylate The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Diphenoxylate.
Erythromycin and Sulfisoxazole	Erythromycin and Sulfisoxazole The risk or severity of QTc prolongation can be increased when Trazodone is combined with Erythromycin.
Guanfacine	Guanfacine The risk or severity of adverse effects can be increased when Guanfacine is combined with Trazodone.
Methylergonovine	Methylergonovine The risk or severity of hypertension can be increased when Methylergometrine is combined with Trazodone.
Naratriptan	Naratriptan The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Naratriptan.
Olsalazine	Olsalazine The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Olsalazine.
Paregoric	Paregoric The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Morphine.
Penbutolol	Penbutolol The risk or severity of QTc prolongation can be increased when Trazodone is combined with Acebutolol.
Pentazocine	Pentazocine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Pentazocine.
Ranitidine	Ranitidine The metabolism of Trazodone can be decreased when combined with Ranitidine.
Reserpine	Reserpine The risk or severity of adverse effects can be increased when Reserpine is combined with Trazodone.
Rizatriptan	Rizatriptan The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Rizatriptan.
Sumatriptan	Sumatriptan The risk or severity of adverse effects can be increased when Sumatriptan is combined with Trazodone.
Tacrolimus	Tacrolimus The risk or severity of QTc prolongation can be increased when Trazodone is combined with Tacrolimus.
Tizanidine	Tizanidine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Tizanidine.
Triamcinolone	Triamcinolone The metabolism of Trazodone can be increased when combined with Triamcinolone.
Zolmitriptan	Zolmitriptan The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Zolmitriptan.
Famotidine Injection	Famotidine Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Famotidine.
Fluconazole Injection	Fluconazole Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Fluconazole.
Foscarnet Injection	Foscarnet Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Foscarnet.
Hydromorphone Injection	Hydromorphone Injection The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Hydromorphone.
Levofloxacin Injection	Levofloxacin Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Levofloxacin.
Meperidine Injection	Meperidine Injection The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Meperidine.
Metoclopramide Injection	Metoclopramide Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Metoclopramide.
Metronidazole Injection	Metronidazole Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Metronidazole.
Morphine Injection	Morphine Injection The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Morphine.
Altretamine	Altretamine Amphetamine may increase the serotonergic activities of Trazodone.
Cyclosporine	Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Trazodone.
Ondansetron	Ondansetron The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ondansetron.
Enoxaparin Injection	Enoxaparin Injection The risk or severity of bleeding can be increased when Trazodone is combined with Enoxaparin.
Granisetron	Granisetron The risk or severity of QTc prolongation can be increased when Trazodone is combined with Granisetron.
Torsemide	Torsemide Trazodone may decrease the antihypertensive activities of Torasemide.
Olanzapine	Olanzapine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Olanzapine.
Alosetron	Alosetron The risk or severity of adverse effects can be increased when Alosetron is combined with Trazodone.
Dofetilide	Dofetilide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Dofetilide.
Entacapone	Entacapone The risk or severity of adverse effects can be increased when Entacapone is combined with Trazodone.
Eprosartan	Eprosartan Trazodone may decrease the antihypertensive activities of Eprosartan.
Hydroxychloroquine	Hydroxychloroquine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Hydroxychloroquine.
Meloxicam	Meloxicam The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Meloxicam.
Oxcarbazepine	Oxcarbazepine The risk or severity of adverse effects can be increased when Oxcarbazepine is combined with Trazodone.
Telmisartan	Telmisartan Trazodone may decrease the antihypertensive activities of Telmisartan.
Zaleplon	Zaleplon The risk or severity of adverse effects can be increased when Zaleplon is combined with Trazodone.
Anakinra	Anakinra The metabolism of Trazodone can be increased when combined with Anakinra.
Desloratadine	Desloratadine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Desloratadine.
Linezolid	Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Trazodone.
Pentosan Polysulfate	Pentosan Polysulfate The risk or severity of bleeding can be increased when Trazodone is combined with Pentosan polysulfate.
Trimipramine	Trimipramine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Trimipramine.
Etanercept Injection	Etanercept Injection The metabolism of Trazodone can be increased when combined with Etanercept.
Glycopyrrolate	Glycopyrrolate Trazodone may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
Modafinil	Modafinil The metabolism of Trazodone can be increased when combined with Modafinil.
Perindopril	Perindopril Trazodone may decrease the antihypertensive activities of Perindopril.
Choline Magnesium Trisalicylate	Choline Magnesium Trisalicylate The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Choline magnesium trisalicylate.
Sirolimus	Sirolimus The metabolism of Sirolimus can be decreased when combined with Trazodone.
Dutasteride	Dutasteride The metabolism of Dutasteride can be decreased when combined with Trazodone.
Epinephrine Injection	Epinephrine Injection The therapeutic efficacy of Epinephrine can be decreased when used in combination with Trazodone.
Eplerenone	Eplerenone The metabolism of Eplerenone can be decreased when combined with Trazodone.
Escitalopram	Escitalopram The risk or severity of QTc prolongation can be increased when Trazodone is combined with Escitalopram.
Olmesartan	Olmesartan Trazodone may decrease the antihypertensive activities of Olmesartan.
Zonisamide	Zonisamide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Zonisamide.
Adalimumab Injection	Adalimumab Injection The metabolism of Trazodone can be increased when combined with Adalimumab.
Aripiprazole	Aripiprazole The risk or severity of QTc prolongation can be increased when Trazodone is combined with Aripiprazole.
Atomoxetine	Atomoxetine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Atomoxetine.
Dexmethylphenidate	Dexmethylphenidate The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Dexmethylphenidate.
Teriparatide Injection	Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Trazodone.
Atazanavir	Atazanavir The risk or severity of QTc prolongation can be increased when Trazodone is combined with Atazanavir.
Almotriptan	Almotriptan The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Almotriptan.
Eletriptan	Eletriptan The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Eletriptan.
Mefloquine	Mefloquine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Mefloquine.
Rosuvastatin	Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Trazodone.
Vardenafil	Vardenafil The risk or severity of QTc prolongation can be increased when Trazodone is combined with Vardenafil.
Alfuzosin	Alfuzosin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Alfuzosin.
Aprepitant	Aprepitant The metabolism of Trazodone can be decreased when combined with Aprepitant.
Tegaserod	Tegaserod The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Tegaserod.
Tadalafil	Tadalafil The risk or severity of hypotension, dyspepsia, and headache can be increased when Trazodone is combined with Tadalafil.
Frovatriptan	Frovatriptan The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Frovatriptan.
Gemifloxacin	Gemifloxacin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Gemifloxacin.
Progesterone	Progesterone The metabolism of Trazodone can be decreased when combined with Progesterone.
Apomorphine Injection	Apomorphine Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Apomorphine.
Infliximab Injection	Infliximab Injection The metabolism of Trazodone can be increased when combined with Infliximab.
Protriptyline	Protriptyline The risk or severity of QTc prolongation can be increased when Trazodone is combined with Protriptyline.
Rifaximin	Rifaximin The serum concentration of Trazodone can be decreased when it is combined with Rifaximin.
Duloxetine	Duloxetine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Duloxetine.
Norethindrone	Norethindrone The metabolism of Norethisterone can be decreased when combined with Trazodone.
Trospium	Trospium Trazodone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Bosentan	Bosentan Trazodone may decrease the antihypertensive activities of Bosentan.
Cinacalcet	Cinacalcet The metabolism of Trazodone can be decreased when combined with Cinacalcet.
Erlotinib	Erlotinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Erlotinib.
Eszopiclone	Eszopiclone The risk or severity of CNS depression can be increased when Trazodone is combined with Eszopiclone.
Solifenacin	Solifenacin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Solifenacin.
Voriconazole	Voriconazole The risk or severity of QTc prolongation can be increased when Trazodone is combined with Voriconazole.
Dextroamphetamine	Dextroamphetamine Amphetamine may increase the serotonergic activities of Trazodone.
Peginterferon Alfa-2b (PEG-Intron)	Peginterferon Alfa-2b (PEG-Intron) The metabolism of Trazodone can be decreased when combined with Peginterferon alfa-2b.
Sodium Oxybate	Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Trazodone.
Ibandronate	Ibandronate The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ibandronate.
Isocarboxazid	Isocarboxazid Isocarboxazid may increase the serotonergic activities of Trazodone.
Ramelteon	Ramelteon The risk or severity of adverse effects can be increased when Ramelteon is combined with Trazodone.
Darifenacin	Darifenacin The metabolism of Darifenacin can be decreased when combined with Trazodone.
Fentanyl	Fentanyl The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Fentanyl.
Pregabalin	Pregabalin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Pregabalin.
Phenylephrine	Phenylephrine The therapeutic efficacy of Phenylephrine can be decreased when used in combination with Trazodone.
Tipranavir	Tipranavir The serum concentration of Tipranavir can be increased when it is combined with Trazodone.
Felbamate	Felbamate The risk or severity of QTc prolongation can be increased when Trazodone is combined with Felbamate.
Ranolazine	Ranolazine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ranolazine.
Abatacept Injection	Abatacept Injection The metabolism of Trazodone can be increased when combined with Abatacept.
Rasagiline	Rasagiline Rasagiline may increase the serotonergic activities of Trazodone.
Imatinib	Imatinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Imatinib.
Gefitinib	Gefitinib The metabolism of Trazodone can be decreased when combined with Gefitinib.
Albuterol	Albuterol The risk or severity of QTc prolongation can be increased when Trazodone is combined with Salbutamol.
Paliperidone	Paliperidone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Paliperidone.
Bortezomib	Bortezomib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Bortezomib.
Oxaliplatin Injection	Oxaliplatin Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Oxaliplatin.
Posaconazole	Posaconazole The risk or severity of QTc prolongation can be increased when Trazodone is combined with Posaconazole.
Primaquine	Primaquine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Primaquine.
Aliskiren	Aliskiren Trazodone may decrease the antihypertensive activities of Aliskiren.
Darunavir	Darunavir The serum concentration of Trazodone can be increased when it is combined with Darunavir.
Dimenhydrinate	Dimenhydrinate The risk or severity of QTc prolongation can be increased when Trazodone is combined with Dimenhydrinate.
Lisdexamfetamine	Lisdexamfetamine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Lisdexamfetamine.
Nabilone	Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Trazodone.
Vorinostat	Vorinostat The risk or severity of QTc prolongation can be increased when Trazodone is combined with Vorinostat.
Sorafenib	Sorafenib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Sorafenib.
Sunitinib	Sunitinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Sunitinib.
Dronabinol	Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Trazodone.
Lapatinib	Lapatinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Lapatinib.
Levocetirizine	Levocetirizine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Levocetirizine.
Dasatinib	Dasatinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Dasatinib.
Mexiletine	Mexiletine The metabolism of Mexiletine can be decreased when combined with Trazodone.
Armodafinil	Armodafinil The metabolism of Trazodone can be increased when combined with Armodafinil.
Temsirolimus	Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Trazodone.
Nilotinib	Nilotinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Nilotinib.
Toremifene	Toremifene The risk or severity of QTc prolongation can be increased when Trazodone is combined with Toremifene.
Budesonide	Budesonide The metabolism of Trazodone can be increased when combined with Budesonide.
Chloramphenicol Injection	Chloramphenicol Injection The metabolism of Trazodone can be decreased when combined with Chloramphenicol.
Desmopressin	Desmopressin The risk or severity of hyponatremia can be increased when Trazodone is combined with Desmopressin.
OnabotulinumtoxinA Injection	OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Trazodone.
RimabotulinumtoxinB Injection	RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Botulinum Toxin Type B is combined with Trazodone.
Arsenic Trioxide Injection	Arsenic Trioxide Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Arsenic trioxide.
Desvenlafaxine	Desvenlafaxine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Desvenlafaxine.
Cevimeline	Cevimeline The metabolism of Cevimeline can be decreased when combined with Trazodone.
Nebivolol	Nebivolol The serum concentration of Nebivolol can be increased when it is combined with Trazodone.
Tretinoin	Tretinoin The metabolism of Tretinoin can be decreased when combined with Trazodone.
Bendamustine Injection	Bendamustine Injection The serum concentration of Bendamustine can be decreased when it is combined with Trazodone.
Flecainide	Flecainide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Flecainide.
Certolizumab Injection	Certolizumab Injection The metabolism of Trazodone can be increased when combined with Certolizumab pegol.
Irinotecan Injection	Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Trazodone.
Praziquantel	Praziquantel The metabolism of Praziquantel can be decreased when combined with Trazodone.
Mitotane	Mitotane The serum concentration of Trazodone can be decreased when it is combined with Mitotane.
Rufinamide	Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Trazodone.
Silodosin	Silodosin Trazodone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Silodosin.
Midazolam	Midazolam The risk or severity of adverse effects can be increased when Trazodone is combined with Midazolam.
Naltrexone Injection	Naltrexone Injection The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Naltrexone.
Milnacipran	Milnacipran The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Milnacipran.
Fesoterodine	Fesoterodine Trazodone may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine.
Degarelix Injection	Degarelix Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Degarelix.
Betaxolol	Betaxolol The risk or severity of QTc prolongation can be increased when Trazodone is combined with Betaxolol.
Iloperidone	Iloperidone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Iloperidone.
Prasugrel	Prasugrel The risk or severity of bleeding can be increased when Trazodone is combined with Prasugrel.
Lacosamide	Lacosamide The risk or severity of adverse effects can be increased when Lacosamide is combined with Trazodone.
Everolimus	Everolimus The serum concentration of Trazodone can be decreased when it is combined with Everolimus.
Tolvaptan (low blood sodium)	Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be decreased when it is combined with Trazodone.
Dronedarone	Dronedarone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Dronedarone.
AbobotulinumtoxinA Injection	AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Trazodone.
Palonosetron Injection	Palonosetron Injection The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Palonosetron.
Saxagliptin	Saxagliptin The metabolism of Saxagliptin can be decreased when combined with Trazodone.
Telavancin Injection	Telavancin Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Telavancin.
Romidepsin Injection	Romidepsin Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Romidepsin.
Tapentadol	Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Trazodone.
Topotecan	Topotecan The serum concentration of Topotecan can be decreased when it is combined with Trazodone.
Golimumab Injection	Golimumab Injection The metabolism of Trazodone can be increased when combined with Golimumab.
Pazopanib	Pazopanib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Pazopanib.
Asenapine	Asenapine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Asenapine.
Vigabatrin	Vigabatrin The risk or severity of adverse effects can be increased when Vigabatrin is combined with Trazodone.
Levonorgestrel	Levonorgestrel The metabolism of Trazodone can be decreased when combined with Levonorgestrel.
Oxymorphone	Oxymorphone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Oxymorphone.
Dabigatran	Dabigatran The risk or severity of bleeding can be increased when Trazodone is combined with Dabigatran.
Tocilizumab Injection	Tocilizumab Injection The metabolism of Trazodone can be increased when combined with Tocilizumab.
Dalfampridine	Dalfampridine The risk or severity of seizure can be increased when Trazodone is combined with Dalfampridine.
Fingolimod	Fingolimod The risk or severity of QTc prolongation can be increased when Trazodone is combined with Fingolimod.
Eribulin Injection	Eribulin Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Eribulin.
IncobotulinumtoxinA Injection	IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Trazodone.
Cabazitaxel Injection	Cabazitaxel Injection The serum concentration of Cabazitaxel can be decreased when it is combined with Trazodone.
Lurasidone	Lurasidone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Lurasidone.
Acetaminophen Injection	Acetaminophen Injection The metabolism of Acetaminophen can be decreased when combined with Trazodone.
Vilazodone	Vilazodone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Vilazodone.
Terbutaline Injection	Terbutaline Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Terbutaline.
Linagliptin	Linagliptin The serum concentration of Linagliptin can be decreased when it is combined with Trazodone.
Rilpivirine	Rilpivirine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Rilpivirine.
Potassium Iodide	Potassium Iodide The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Trazodone.
Cyclophosphamide Injection	Cyclophosphamide Injection The metabolism of Trazodone can be decreased when combined with Cyclophosphamide.
Abiraterone	Abiraterone The metabolism of Trazodone can be decreased when combined with Abiraterone.
Triptorelin Injection	Triptorelin Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Triptorelin.
Rivaroxaban	Rivaroxaban The risk or severity of bleeding can be increased when Trazodone is combined with Rivaroxaban.
Ticagrelor	Ticagrelor The risk or severity of bleeding can be increased when Trazodone is combined with Ticagrelor.
Brentuximab Vedotin Injection	Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be decreased when it is combined with Trazodone.
Vandetanib	Vandetanib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Vandetanib.
Clobazam	Clobazam The metabolism of Trazodone can be decreased when combined with Clobazam.
Vemurafenib	Vemurafenib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Vemurafenib.
Ivacaftor	Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Trazodone.
Axitinib	Axitinib The serum concentration of Axitinib can be decreased when it is combined with Trazodone.
Crizotinib	Crizotinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Crizotinib.
Cabergoline	Cabergoline The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Cabergoline.
Naloxone Injection	Naloxone Injection The serum concentration of Trazodone can be increased when it is combined with Naloxone.
Ambrisentan	Ambrisentan The metabolism of Ambrisentan can be decreased when combined with Trazodone.
Fondaparinux Injection	Fondaparinux Injection The risk or severity of bleeding can be increased when Trazodone is combined with Fondaparinux.
Ezogabine	Ezogabine The risk or severity of adverse effects can be increased when Tiagabine is combined with Trazodone.
Carfilzomib Injection	Carfilzomib Injection The serum concentration of Carfilzomib can be decreased when it is combined with Trazodone.
Iloprost	Iloprost The risk or severity of bleeding can be increased when Trazodone is combined with Iloprost.
Enzalutamide	Enzalutamide The serum concentration of Trazodone can be decreased when it is combined with Enzalutamide.
Mirabegron	Mirabegron The risk or severity of QTc prolongation can be increased when Trazodone is combined with Mirabegron.
Regorafenib	Regorafenib The serum concentration of Regorafenib can be decreased when it is combined with Trazodone.
Bosutinib	Bosutinib The serum concentration of Bosutinib can be decreased when it is combined with Trazodone.
Bedaquiline	Bedaquiline The risk or severity of QTc prolongation can be increased when Trazodone is combined with Bedaquiline.
Icosapent Ethyl	Icosapent Ethyl The risk or severity of bleeding can be increased when Trazodone is combined with Icosapent ethyl.
Alogliptin	Alogliptin The metabolism of Alogliptin can be decreased when combined with Trazodone.
Ponatinib	Ponatinib The metabolism of Ponatinib can be decreased when combined with Trazodone.
Pomalidomide	Pomalidomide The serum concentration of Trazodone can be decreased when it is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection	Ado-trastuzumab Emtansine Injection The serum concentration of Trastuzumab emtansine can be decreased when it is combined with Trazodone.
Apixaban	Apixaban The risk or severity of bleeding can be increased when Trazodone is combined with Apixaban.
Dabrafenib	Dabrafenib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Dabrafenib.
Ospemifene	Ospemifene The metabolism of Trazodone can be decreased when combined with Ospemifene.
Afatinib	Afatinib The serum concentration of Afatinib can be decreased when it is combined with Trazodone.
Levomilnacipran	Levomilnacipran The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Levomilnacipran.
Vortioxetine	Vortioxetine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Vortioxetine.
Perampanel	Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Trazodone.
Ibrutinib	Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Trazodone.
Avanafil	Avanafil The risk or severity of hypotension, dyspepsia, and headache can be increased when Avanafil is combined with Trazodone.
Ketorolac Injection	Ketorolac Injection The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Ketorolac.
Sofosbuvir	Sofosbuvir The serum concentration of Sofosbuvir can be decreased when it is combined with Trazodone.
Dapagliflozin	Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Trazodone.
Apremilast	Apremilast The metabolism of Trazodone can be increased when combined with Apremilast.
Droxidopa	Droxidopa The therapeutic efficacy of Droxidopa can be decreased when used in combination with Trazodone.
Ceritinib	Ceritinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ceritinib.
Siltuximab Injection	Siltuximab Injection The metabolism of Trazodone can be increased when combined with Siltuximab.
Eslicarbazepine	Eslicarbazepine The risk or severity of adverse effects can be increased when Eslicarbazepine is combined with Trazodone.
Testosterone Injection	Testosterone Injection The metabolism of Trazodone can be decreased when combined with Testosterone.
Oritavancin Injection	Oritavancin Injection The metabolism of Trazodone can be decreased when combined with Oritavancin.
Vorapaxar	Vorapaxar The risk or severity of bleeding can be increased when Trazodone is combined with Vorapaxar.
Hydrocodone	Hydrocodone Hydrocodone may increase the central nervous system depressant (CNS depressant) activities of Trazodone.
Suvorexant	Suvorexant Trazodone may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Edoxaban	Edoxaban The risk or severity of bleeding can be increased when Trazodone is combined with Edoxaban.
Olaparib	Olaparib The metabolism of Olaparib can be decreased when combined with Trazodone.
Methamphetamine	Methamphetamine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Metamfetamine.
Tasimelteon	Tasimelteon The risk or severity of adverse effects can be increased when Tasimelteon is combined with Trazodone.
Riociguat	Riociguat Trazodone may decrease the antihypertensive activities of Riociguat.
Secukinumab Injection	Secukinumab Injection The metabolism of Trazodone can be increased when combined with Secukinumab.
Risperidone Injection	Risperidone Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Risperidone.
Lenvatinib	Lenvatinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Lenvatinib.
Naloxegol	Naloxegol The metabolism of Trazodone can be decreased when combined with Naloxegol.
Panobinostat	Panobinostat The risk or severity of QTc prolongation can be increased when Trazodone is combined with Panobinostat.
Haloperidol Injection	Haloperidol Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Haloperidol.
Ivabradine	Ivabradine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ivabradine.
Macitentan	Macitentan Trazodone may decrease the antihypertensive activities of Macitentan.
Flibanserin	Flibanserin The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Flibanserin.
Rolapitant	Rolapitant The metabolism of Trazodone can be decreased when combined with Rolapitant.
Daclatasvir	Daclatasvir The metabolism of Daclatasvir can be decreased when combined with Trazodone.
Brexpiprazole	Brexpiprazole The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Brexpiprazole.
Ziprasidone Injection	Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ziprasidone.
Cariprazine	Cariprazine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Cariprazine.
Eluxadoline	Eluxadoline The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Eluxadoline.
Cobimetinib	Cobimetinib The serum concentration of Cobimetinib can be decreased when it is combined with Trazodone.
Trabectedin Injection	Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Trazodone.
Osimertinib	Osimertinib The serum concentration of Osimertinib can be decreased when it is combined with Trazodone.
Dexamethasone Injection	Dexamethasone Injection The serum concentration of Trazodone can be decreased when it is combined with Dexamethasone.
Defibrotide Injection	Defibrotide Injection The risk or severity of bleeding can be increased when Trazodone is combined with Defibrotide.
Brivaracetam Injection	Brivaracetam Injection The risk or severity of adverse effects can be increased when Brivaracetam is combined with Trazodone.
Venetoclax	Venetoclax The serum concentration of Venetoclax can be decreased when it is combined with Trazodone.
Cobicistat	Cobicistat The serum concentration of Trazodone can be increased when it is combined with Cobicistat.
Midodrine	Midodrine The therapeutic efficacy of Midodrine can be decreased when used in combination with Trazodone.
Selexipag	Selexipag Trazodone may decrease the antihypertensive activities of Selexipag.
Pimavanserin	Pimavanserin The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Pimavanserin.
Diphenhydramine Injection	Diphenhydramine Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Diphenhydramine.
Furosemide Injection	Furosemide Injection Trazodone may decrease the antihypertensive activities of Furosemide.
Rucaparib	Rucaparib The metabolism of Trazodone can be decreased when combined with Rucaparib.
Ribociclib	Ribociclib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ribociclib.
Parathyroid Hormone Injection	Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Trazodone.
Doxepin (Insomnia)	Doxepin (Insomnia) The risk or severity of QTc prolongation can be increased when Trazodone is combined with Doxepin.
Deutetrabenazine	Deutetrabenazine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Deutetrabenazine.
Valbenazine	Valbenazine The metabolism of Valbenazine can be decreased when combined with Trazodone.
Deflazacort	Deflazacort The metabolism of Trazodone can be increased when combined with Deflazacort.
Safinamide	Safinamide Safinamide may increase the serotonergic activities of Trazodone.
Midostaurin	Midostaurin The serum concentration of Trazodone can be increased when it is combined with Midostaurin.
Abaloparatide Injection	Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Trazodone.
Enasidenib	Enasidenib The metabolism of Enasidenib can be decreased when combined with Trazodone.
Inotuzumab Ozogamicin Injection	Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be decreased when it is combined with Trazodone.
Copanlisib Injection	Copanlisib Injection The serum concentration of Copanlisib can be decreased when it is combined with Trazodone.
Delafloxacin	Delafloxacin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Delafloxacin.
Abemaciclib	Abemaciclib The serum concentration of Abemaciclib can be decreased when it is combined with Trazodone.
Betrixaban	Betrixaban The risk or severity of bleeding can be increased when Trazodone is combined with Betrixaban.
Acalabrutinib	Acalabrutinib The metabolism of Trazodone can be decreased when combined with Acalabrutinib.
Letermovir	Letermovir The metabolism of Trazodone can be decreased when combined with Letermovir.
Tetrabenazine	Tetrabenazine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Tetrabenazine.
Buprenorphine Injection	Buprenorphine Injection Trazodone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Apalutamide	Apalutamide The serum concentration of Trazodone can be decreased when it is combined with Apalutamide.
Fostamatinib	Fostamatinib The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Trazodone.
Lofexidine	Lofexidine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Lofexidine.
Eliglustat	Eliglustat The risk or severity of QTc prolongation can be increased when Trazodone is combined with Eliglustat.
Encorafenib	Encorafenib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Encorafenib.
Binimetinib	Binimetinib The serum concentration of Binimetinib can be decreased when it is combined with Trazodone.
Ivosidenib	Ivosidenib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ivosidenib.
Elagolix	Elagolix The metabolism of Elagolix can be decreased when combined with Trazodone.
Doravirine	Doravirine The metabolism of Doravirine can be decreased when combined with Trazodone.
Tafenoquine	Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Trazodone.
Cannabidiol	Cannabidiol The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Cannabidiol.
Dacomitinib	Dacomitinib The serum concentration of Trazodone can be decreased when it is combined with Dacomitinib.
Stiripentol	Stiripentol The serum concentration of Trazodone can be increased when it is combined with Stiripentol.
Talazoparib	Talazoparib The serum concentration of Talazoparib can be decreased when it is combined with Trazodone.
Gilteritinib	Gilteritinib The therapeutic efficacy of Trazodone can be decreased when used in combination with Gilteritinib.
Glasdegib	Glasdegib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Glasdegib.
Lorlatinib	Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Trazodone.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Trazodone.
Rifamycin	Rifamycin The serum concentration of Trazodone can be decreased when it is combined with Rifamycin.
Emapalumab-lzsg Injection	Emapalumab-lzsg Injection The metabolism of Trazodone can be increased when combined with Emapalumab.
Siponimod	Siponimod The risk or severity of hypertension can be increased when Trazodone is combined with Siponimod.
Caplacizumab-yhdp Injection	Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Trazodone is combined with Caplacizumab.
Brexanolone Injection	Brexanolone Injection The risk or severity of adverse effects can be increased when Brexanolone is combined with Trazodone.
Solriamfetol	Solriamfetol The risk or severity of hypertension can be increased when Solriamfetol is combined with Trazodone.
Triclabendazole	Triclabendazole The risk or severity of QTc prolongation can be increased when Trazodone is combined with Triclabendazole.
Entrectinib	Entrectinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Entrectinib.
Istradefylline	Istradefylline The metabolism of Istradefylline can be decreased when combined with Trazodone.
Pitolisant	Pitolisant The therapeutic efficacy of Pitolisant can be decreased when used in combination with Trazodone.
Fedratinib	Fedratinib The metabolism of Trazodone can be decreased when combined with Fedratinib.
Lefamulin	Lefamulin Trazodone may increase the QTc-prolonging activities of Lefamulin.
Phenytoin Injection	Phenytoin Injection The serum concentration of Phenytoin can be increased when it is combined with Trazodone.
Fosphenytoin Injection	Fosphenytoin Injection The serum concentration of Fosphenytoin can be increased when it is combined with Trazodone.
Lumateperone	Lumateperone The risk or severity of adverse effects can be increased when Lumateperone is combined with Trazodone.
Lasmiditan	Lasmiditan The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Lasmiditan.
Cenobamate	Cenobamate The serum concentration of Trazodone can be decreased when it is combined with Cenobamate.
Selumetinib	Selumetinib The metabolism of Selumetinib can be decreased when combined with Trazodone.
Tucatinib	Tucatinib The metabolism of Tucatinib can be decreased when combined with Trazodone.
Selpercatinib	Selpercatinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Selpercatinib.
Lemborexant	Lemborexant The risk or severity of adverse effects can be increased when Trazodone is combined with Lemborexant.
Daratumumab and Hyaluronidase-fihj Injection	Daratumumab and Hyaluronidase-fihj Injection The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Trazodone.
Fenfluramine	Fenfluramine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Fenfluramine.
Fostemsavir	Fostemsavir The risk or severity of QTc prolongation can be increased when Trazodone is combined with Fostemsavir.
Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf Injection	Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf Injection The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Trazodone.
Octreotide	Octreotide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Octreotide.
Pralsetinib	Pralsetinib The metabolism of Trazodone can be decreased when combined with Pralsetinib.
Satralizumab-mwge Injection	Satralizumab-mwge Injection The serum concentration of Trazodone can be decreased when it is combined with Satralizumab.
Naxitamab-gqgk Injection	Naxitamab-gqgk Injection The risk or severity of hypertension can be increased when Trazodone is combined with Naxitamab.
Relugolix	Relugolix The serum concentration of Relugolix can be decreased when it is combined with Trazodone.
Viloxazine	Viloxazine The risk or severity of adverse effects can be increased when Trazodone is combined with Viloxazine.
Theophylline	Theophylline The metabolism of Theophylline can be decreased when combined with Trazodone.
Fenoprofen	Fenoprofen The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Fenoprofen.
Indomethacin	Indomethacin The risk or severity of gastrointestinal bleeding can be increased when Indomethacin is combined with Trazodone.
Mefenamic Acid	Mefenamic Acid The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Mefenamic acid.
Naproxen	Naproxen The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Naproxen.
Tolmetin	Tolmetin The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Tolmetin.
Sulindac	Sulindac The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Sulindac.
Hydroxyurea	Hydroxyurea The metabolism of Trazodone can be decreased when combined with Hydroxyurea.
Phenobarbital	Phenobarbital The serum concentration of Trazodone can be decreased when it is combined with Phenobarbital.
Metaxalone	Metaxalone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Metaxalone.
Levorphanol	Levorphanol The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Levorphanol.
Primidone	Primidone The serum concentration of Trazodone can be decreased when it is combined with Primidone.
Methsuximide	Methsuximide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Methsuximide.
Diethylpropion	Diethylpropion The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Diethylpropion.
Chlorpromazine	Chlorpromazine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Chlorpromazine.
Diazepam	Diazepam The risk or severity of adverse effects can be increased when Trazodone is combined with Diazepam.
Oxazepam	Oxazepam The risk or severity of adverse effects can be increased when Trazodone is combined with Oxazepam.
Flurazepam	Flurazepam The risk or severity of adverse effects can be increased when Trazodone is combined with Flurazepam.
Clorazepate	Clorazepate The risk or severity of adverse effects can be increased when Clorazepic acid is combined with Trazodone.
Lorazepam	Lorazepam The risk or severity of adverse effects can be increased when Lorazepam is combined with Trazodone.
Phenoxybenzamine	Phenoxybenzamine Trazodone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Phenoxybenzamine.
Amantadine	Amantadine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Amantadine.
Codeine	Codeine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Codeine.
Meprobamate	Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Trazodone.
Chlordiazepoxide	Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Trazodone.
Bromocriptine	Bromocriptine Trazodone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Bromocriptine.
Metaproterenol	Metaproterenol The therapeutic efficacy of Orciprenaline can be decreased when used in combination with Trazodone.
Tranylcypromine	Tranylcypromine Tranylcypromine may increase the serotonergic activities of Trazodone.
Phenelzine	Phenelzine Phenelzine may increase the serotonergic activities of Trazodone.
Procarbazine	Procarbazine Procarbazine may increase the serotonergic activities of Trazodone.
Ergoloid Mesylates	Ergoloid Mesylates The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Ergoloid mesylate.
Minocycline	Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Trazodone.
Prochlorperazine	Prochlorperazine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Prochlorperazine.
Thioridazine	Thioridazine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Thioridazine.
Trifluoperazine	Trifluoperazine Trazodone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Trifluoperazine.
Dapsone	Dapsone The metabolism of Trazodone can be decreased when combined with Dapsone.
Oxycodone	Oxycodone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Oxycodone.
Methadone	Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Trazodone.
Oxybutynin	Oxybutynin The metabolism of Oxybutynin can be decreased when combined with Trazodone.
Benztropine	Benztropine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Benzatropine.
Maprotiline	Maprotiline The risk or severity of QTc prolongation can be increased when Trazodone is combined with Maprotiline.
Ibuprofen	Ibuprofen The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Ibuprofen.
Trihexyphenidyl	Trihexyphenidyl Trazodone may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine	Orphenadrine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Orphenadrine.
Perphenazine	Perphenazine The risk or severity of adverse effects can be increased when Trazodone is combined with Perphenazine.
Fluphenazine	Fluphenazine The risk or severity of adverse effects can be increased when Fluphenazine is combined with Trazodone.
Phentermine	Phentermine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Phentermine.
Methylphenidate	Methylphenidate The risk or severity of hypertension can be increased when Methylphenidate is combined with Trazodone.
Amoxapine	Amoxapine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Amoxapine.
Sulfasalazine	Sulfasalazine The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Sulfasalazine.
Hydrocortisone	Hydrocortisone The metabolism of Hydrocortisone can be decreased when combined with Trazodone.
Doxorubicin	Doxorubicin The serum concentration of Doxorubicin can be decreased when it is combined with Trazodone.
Dactinomycin	Dactinomycin The serum concentration of Dactinomycin can be decreased when it is combined with Trazodone.
Carbamazepine	Carbamazepine The serum concentration of Trazodone can be decreased when it is combined with Carbamazepine.
Molindone	Molindone The risk or severity of adverse effects can be increased when Trazodone is combined with Molindone.
Methyldopa	Methyldopa The therapeutic efficacy of Methyldopa can be decreased when used in combination with Trazodone.
Clonidine	Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Trazodone.
Prazosin	Prazosin Prazosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Trazodone.
Hydralazine	Hydralazine Trazodone may decrease the antihypertensive activities of Hydralazine.
Cimetidine	Cimetidine The metabolism of Trazodone can be decreased when combined with Cimetidine.
Warfarin	Warfarin Trazodone may decrease the anticoagulant activities of Warfarin.
Clonazepam	Clonazepam The risk or severity of adverse effects can be increased when Clonazepam is combined with Trazodone.
Loperamide	Loperamide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Loperamide.
Promethazine	Promethazine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Promethazine.
Meclofenamate	Meclofenamate The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Meclofenamic acid.
Daunorubicin	Daunorubicin The metabolism of Trazodone can be increased when combined with Daunorubicin.
Digoxin	Digoxin The serum concentration of Digoxin can be increased when it is combined with Trazodone.
Loxapine	Loxapine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Loxapine.
Chloroquine	Chloroquine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Chloroquine.
Quinine	Quinine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Quinine.
Ethosuximide	Ethosuximide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ethosuximide.
Sulfinpyrazone	Sulfinpyrazone The risk or severity of bleeding can be increased when Trazodone is combined with Sulfinpyrazone.
Chlorothiazide	Chlorothiazide The risk or severity of hyponatremia can be increased when Trazodone is combined with Chlorothiazide.
Chlorthalidone	Chlorthalidone The risk or severity of hyponatremia can be increased when Trazodone is combined with Chlorthalidone.
Metolazone	Metolazone The risk or severity of hyponatremia can be increased when Trazodone is combined with Metolazone.
Clindamycin Injection	Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Trazodone.
Secobarbital	Secobarbital The risk or severity of adverse effects can be increased when Secobarbital is combined with Trazodone.
Desipramine	Desipramine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Desipramine.
Amitriptyline	Amitriptyline The risk or severity of QTc prolongation can be increased when Trazodone is combined with Amitriptyline.
Imipramine	Imipramine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Imipramine.
Quinidine	Quinidine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Quinidine.
Procainamide	Procainamide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Procainamide.
Isoniazid	Isoniazid The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Isoniazid.
Rifampin	Rifampin The serum concentration of Trazodone can be decreased when it is combined with Rifampicin.
Disopyramide	Disopyramide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Disopyramide.
Valproic Acid	Valproic Acid The risk or severity of QTc prolongation can be increased when Trazodone is combined with Valproic acid.
Tamoxifen	Tamoxifen The risk or severity of QTc prolongation can be increased when Trazodone is combined with Tamoxifen.
Butabarbital	Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Trazodone.
Levothyroxine	Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Trazodone.
Liothyronine	Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Trazodone.
Methimazole	Methimazole The serum concentration of Trazodone can be increased when it is combined with Methimazole.
Propylthiouracil	Propylthiouracil The therapeutic efficacy of Propylthiouracil can be decreased when used in combination with Trazodone.
Dextromethorphan	Dextromethorphan The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Dextromethorphan.
Cyclobenzaprine	Cyclobenzaprine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Cyclobenzaprine.
Niacin	Niacin The metabolism of Trazodone can be decreased when combined with Niacin.
Baclofen	Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Trazodone.
Doxylamine	Doxylamine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Doxylamine.
Cyproheptadine	Cyproheptadine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Cyproheptadine.
Clemastine	Clemastine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Clemastine.
Chlorpheniramine	Chlorpheniramine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Chlorpheniramine.
Brompheniramine	Brompheniramine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Dexbrompheniramine.
Meclizine	Meclizine The risk or severity of adverse effects can be increased when Meclizine is combined with Trazodone.
Methyclothiazide	Methyclothiazide The risk or severity of hyponatremia can be increased when Trazodone is combined with Methyclothiazide.
Hydrochlorothiazide	Hydrochlorothiazide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Hydrochlorothiazide.
Dantrolene	Dantrolene The risk or severity of adverse effects can be increased when Dantrolene is combined with Trazodone.
Chlorzoxazone	Chlorzoxazone The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Trazodone.
Carisoprodol	Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Trazodone.
Methocarbamol	Methocarbamol The risk or severity of adverse effects can be increased when Methocarbamol is combined with Trazodone.
Disulfiram	Disulfiram The risk or severity of QTc prolongation can be increased when Trazodone is combined with Disulfiram.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) The risk or severity of QTc prolongation can be increased when Trazodone is combined with Propranolol.
Minoxidil	Minoxidil Trazodone may decrease the antihypertensive activities of Minoxidil.
Pseudoephedrine	Pseudoephedrine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Pseudoephedrine.
Nortriptyline	Nortriptyline The risk or severity of QTc prolongation can be increased when Trazodone is combined with Nortriptyline.
Nadolol	Nadolol The serum concentration of Nadolol can be increased when it is combined with Trazodone.
Butorphanol Injection	Butorphanol Injection The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Butorphanol.
Nalbuphine Injection	Nalbuphine Injection The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Nalbuphine.
Oxytocin Injection	Oxytocin Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Oxytocin.
Trimethobenzamide	Trimethobenzamide The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Trazodone.
Flavoxate	Flavoxate Trazodone may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
Papaverine	Papaverine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Papaverine.
Fluorouracil Injection	Fluorouracil Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Fluorouracil.
Acetazolamide	Acetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Trazodone.
Calcitonin Salmon Injection	Calcitonin Salmon Injection The therapeutic efficacy of Salmon calcitonin can be decreased when used in combination with Trazodone.
Ketoconazole	Ketoconazole The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ketoconazole.
Pyrantel	Pyrantel The risk or severity of adverse effects can be increased when Pyrantel is combined with Trazodone.
Vincristine Injection	Vincristine Injection The serum concentration of Vincristine can be decreased when it is combined with Trazodone.
Captopril	Captopril Trazodone may decrease the antihypertensive activities of Captopril.
Dipyridamole	Dipyridamole The risk or severity of bleeding can be increased when Trazodone is combined with Dipyridamole.
Isoxsuprine	Isoxsuprine The therapeutic efficacy of Isoxsuprine can be decreased when used in combination with Trazodone.
Vinblastine	Vinblastine The serum concentration of Trazodone can be decreased when it is combined with Vinblastine.
Metoprolol	Metoprolol The metabolism of Metoprolol can be decreased when combined with Trazodone.
Hydroxyzine	Hydroxyzine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Hydroxyzine.
Thiothixene	Thiothixene The risk or severity of QTc prolongation can be increased when Trazodone is combined with Thiothixene.
Aspirin	Aspirin The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Acetylsalicylic acid.
Salsalate	Salsalate The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Salsalate.
Alprazolam	Alprazolam The risk or severity of adverse effects can be increased when Alprazolam is combined with Trazodone.
Temazepam	Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Trazodone.
Triazolam	Triazolam The risk or severity of adverse effects can be increased when Trazodone is combined with Triazolam.
Dicyclomine	Dicyclomine Trazodone may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
Hyoscyamine	Hyoscyamine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Hyoscyamine.
Propantheline	Propantheline Trazodone may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
Diltiazem	Diltiazem The risk or severity of QTc prolongation can be increased when Trazodone is combined with Diltiazem.
Nifedipine	Nifedipine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Nifedipine.
Timolol	Timolol The risk or severity of QTc prolongation can be increased when Trazodone is combined with Timolol.
Verapamil	Verapamil Verapamil may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Trazodone.
Atenolol	Atenolol The serum concentration of Atenolol can be increased when it is combined with Trazodone.
Pindolol	Pindolol The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Pindolol.
Diflunisal	Diflunisal The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Diflunisal.
Piroxicam	Piroxicam The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Piroxicam.
Etoposide	Etoposide The serum concentration of Etoposide can be decreased when it is combined with Trazodone.
Glyburide	Glyburide The metabolism of Glyburide can be decreased when combined with Trazodone.
Indapamide	Indapamide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Indapamide.
Pentoxifylline	Pentoxifylline The risk or severity of bleeding can be increased when Trazodone is combined with Pentoxifylline.
Pentamidine Injection	Pentamidine Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Pentamidine.
Labetalol	Labetalol Labetalol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Trazodone.
Leuprolide Injection	Leuprolide Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Leuprolide.
Guanabenz	Guanabenz The therapeutic efficacy of Guanabenz can be decreased when used in combination with Trazodone.
Ketoprofen	Ketoprofen The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Ketoprofen.
Pimozide	Pimozide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Pimozide.
Enalapril	Enalapril Trazodone may decrease the antihypertensive activities of Enalapril.
Flurbiprofen	Flurbiprofen The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Flurbiprofen.
Amiodarone	Amiodarone Trazodone may increase the QTc-prolonging activities of Amiodarone.
Buspirone	Buspirone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Buspirone.
Lovastatin	Lovastatin The metabolism of Trazodone can be decreased when combined with Lovastatin.
Ciprofloxacin	Ciprofloxacin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ciprofloxacin.
Mesalamine	Mesalamine The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Mesalazine.
Diclofenac	Diclofenac The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Diclofenac.
Fluoxetine	Fluoxetine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Fluoxetine.
Nimodipine	Nimodipine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Nimodipine.
Clozapine	Clozapine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Clozapine.
Estazolam	Estazolam The risk or severity of adverse effects can be increased when Trazodone is combined with Estazolam.
Idarubicin	Idarubicin The metabolism of Idarubicin can be decreased when combined with Trazodone.
Ofloxacin	Ofloxacin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ofloxacin.
Clarithromycin	Clarithromycin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Clarithromycin.
Benazepril	Benazepril Trazodone may decrease the antihypertensive activities of Benazepril.
Etodolac	Etodolac The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Etodolac.
Felodipine	Felodipine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Felodipine.
Fosinopril	Fosinopril Trazodone may decrease the antihypertensive activities of Fosinopril.
Nabumetone	Nabumetone The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Nabumetone.
Quinapril	Quinapril Trazodone may decrease the antihypertensive activities of Quinapril.
Ramipril	Ramipril Trazodone may decrease the antihypertensive activities of Ramipril.
Simvastatin	Simvastatin The metabolism of Trazodone can be decreased when combined with Simvastatin.
Amlodipine	Amlodipine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Amlodipine.
Teniposide Injection	Teniposide Injection The metabolism of Trazodone can be decreased when combined with Teniposide.
Itraconazole	Itraconazole The risk or severity of QTc prolongation can be increased when Trazodone is combined with Itraconazole.
Lisinopril	Lisinopril Trazodone may decrease the antihypertensive activities of Lisinopril.
Oxaprozin	Oxaprozin The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Oxaprozin.
Sotalol	Sotalol The risk or severity of QTc prolongation can be increased when Trazodone is combined with Sotalol.
Bisoprolol	Bisoprolol The serum concentration of Bisoprolol can be increased when it is combined with Trazodone.
Zolpidem	Zolpidem Trazodone may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin	Doxazosin Doxazosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Trazodone.
Terazosin	Terazosin Trazodone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Terazosin.
Isradipine	Isradipine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Isradipine.
Omeprazole	Omeprazole The metabolism of Trazodone can be decreased when combined with Omeprazole.
Cisapride	Cisapride The risk or severity of QTc prolongation can be increased when Trazodone is combined with Cisapride.
Gabapentin	Gabapentin The risk or severity of adverse effects can be increased when Gabapentin is combined with Trazodone.
Fluvastatin	Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Trazodone.
Venlafaxine	Venlafaxine Venlafaxine may increase the serotonergic activities of Trazodone.
Fluvoxamine	Fluvoxamine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Fluvoxamine.
Nefazodone	Nefazodone The serum concentration of Nefazodone can be increased when it is combined with Trazodone.
Lamotrigine	Lamotrigine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Lamotrigine.
Losartan	Losartan The risk or severity of QTc prolongation can be increased when Trazodone is combined with Losartan.
Tramadol	Tramadol The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Tramadol.
Vinorelbine Injection	Vinorelbine Injection The metabolism of Trazodone can be decreased when combined with Vinorelbine.
Moexipril	Moexipril The risk or severity of QTc prolongation can be increased when Trazodone is combined with Moexipril.
Lansoprazole	Lansoprazole The metabolism of Trazodone can be decreased when combined with Lansoprazole.
Ifosfamide Injection	Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Trazodone.
Nicardipine	Nicardipine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Nicardipine.
Bupropion	Bupropion The risk or severity of seizure can be increased when Trazodone is combined with Bupropion.
Ticlopidine	Ticlopidine The risk or severity of bleeding can be increased when Trazodone is combined with Ticlopidine.
Saquinavir	Saquinavir The risk or severity of QTc prolongation can be increased when Trazodone is combined with Saquinavir.
Dalteparin Injection	Dalteparin Injection The risk or severity of bleeding can be increased when Trazodone is combined with Dalteparin.
Nisoldipine	Nisoldipine The risk or severity of hypotension can be increased when Nisoldipine is combined with Trazodone.
Riluzole	Riluzole The risk or severity of adverse effects can be increased when Riluzole is combined with Trazodone.
Gemcitabine Injection	Gemcitabine Injection The serum concentration of Gemcitabine can be decreased when it is combined with Trazodone.
Indinavir	Indinavir The metabolism of Trazodone can be decreased when combined with Indinavir.
Ritonavir	Ritonavir The serum concentration of Ritonavir can be increased when it is combined with Trazodone.
Docetaxel Injection	Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Trazodone.
Clomipramine	Clomipramine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Clomipramine.
Mirtazapine	Mirtazapine Trazodone may increase the serotonergic activities of Mirtazapine.
Trandolapril	Trandolapril Trazodone may decrease the antihypertensive activities of Trandolapril.
Topiramate	Topiramate The risk or severity of adverse effects can be increased when Topiramate is combined with Trazodone.
Valsartan	Valsartan Trazodone may decrease the antihypertensive activities of Valsartan.
Pramipexole	Pramipexole Trazodone may increase the sedative activities of Pramipexole.
Donepezil	Donepezil The risk or severity of QTc prolongation can be increased when Trazodone is combined with Donepezil.
Nelfinavir	Nelfinavir The risk or severity of QTc prolongation can be increased when Trazodone is combined with Nelfinavir.
Azithromycin	Azithromycin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Azithromycin.
Loratadine	Loratadine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Loratadine.
Carvedilol	Carvedilol Trazodone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Carvedilol.
Flutamide	Flutamide The metabolism of Trazodone can be decreased when combined with Flutamide.
Selegiline	Selegiline Selegiline may increase the serotonergic activities of Trazodone.
Bicalutamide	Bicalutamide The metabolism of Trazodone can be decreased when combined with Bicalutamide.
Sertraline	Sertraline The risk or severity of QTc prolongation can be increased when Trazodone is combined with Sertraline.
Propafenone	Propafenone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Propafenone.
Irbesartan	Irbesartan Trazodone may decrease the antihypertensive activities of Irbesartan.
Tamsulosin	Tamsulosin Trazodone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Tamsulosin.
Ropinirole	Ropinirole Trazodone may increase the sedative activities of Ropinirole.
Finasteride	Finasteride The metabolism of Finasteride can be decreased when combined with Trazodone.
Quetiapine	Quetiapine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Quetiapine.
Cetirizine	Cetirizine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Cetirizine.
Paroxetine	Paroxetine The risk or severity of serotonin syndrome can be increased when Paroxetine is combined with Trazodone.
Tolcapone	Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Trazodone.
Citalopram	Citalopram The risk or severity of QTc prolongation can be increased when Trazodone is combined with Citalopram.
Efavirenz	Efavirenz The risk or severity of QTc prolongation can be increased when Trazodone is combined with Efavirenz.
Sildenafil	Sildenafil The metabolism of Trazodone can be decreased when combined with Sildenafil.
Celecoxib	Celecoxib The risk or severity of bleeding can be increased when Celecoxib is combined with Trazodone.
Rosiglitazone	Rosiglitazone The metabolism of Trazodone can be decreased when combined with Rosiglitazone.
Tolterodine	Tolterodine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Tolterodine.
Thalidomide	Thalidomide Trazodone may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Balsalazide	Balsalazide The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Balsalazide.
Nateglinide	Nateglinide The metabolism of Nateglinide can be decreased when combined with Trazodone.
Galantamine	Galantamine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Galantamine.
Levetiracetam	Levetiracetam The risk or severity of adverse effects can be increased when Trazodone is combined with Levetiracetam.
Rabeprazole	Rabeprazole The metabolism of Trazodone can be decreased when combined with Rabeprazole.
Terbinafine	Terbinafine The metabolism of Trazodone can be decreased when combined with Terbinafine.