Trazodone
Generic name: Pronounced as (traz' oh done)
Medical Content Reviewed By HelloPharmacist Staff
Last Revised - 01/15/2022
On this page
- Why is this medication prescribed?
- How should this medicine be used?
- Other uses for this medicine
- What special precautions should I follow?
- What special dietary instructions should I follow?
- What should I do if I forget a dose?
- What side effects can this medication cause?
- What should I know about STORAGE and DISPOSAL of this medication?
- What should I do in case of OVERDOSE?
- What OTHER INFORMATION should I know?
- Drug interactions
IMPORTANT WARNING
A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as trazodone during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant. Children younger than 18 years of age should not normally take trazodone, but in some cases, a doctor may decide that trazodone is the best medication to treat a child's condition.
You should know that your mental health may change in unexpected ways when you take trazodone or other antidepressants even if you are an adult over age 24. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor when you are unable to seek treatment on your own.
Your healthcare provider will want to see you often while you are taking trazodone, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor.
The doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with trazodone. Read the information carefully and ask your doctor or pharmacist if you have any questions. You also can obtain the Medication Guide from the FDA website: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm.
No matter your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal. This risk is higher if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood) or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you.
Why is this medication prescribed?
Trazodone is used to treat depression. Trazodone is in a class of medications called serotonin modulators. It works by increasing the amount of serotonin, a natural substance in the brain that helps maintain mental balance.
How should this medicine be used?
Trazodone comes as a tablet to take by mouth. The tablet is usually taken with a meal or light snack two or more times a day. To help you remember to take trazodone, take it around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take trazodone exactly as directed. Do not take more or less of it, take it more often, or take it for a longer time than prescribed by your doctor.
Swallow the tablets whole or broken in half on the score mark.
Your doctor may start you on a low dose of trazodone and gradually increase your dose, not more than once every 3 to 4 days. Your doctor may decrease your dose once your condition is controlled.
Trazodone controls depression, but does not cure it. It may take 2 weeks or longer before you feel the full benefit of trazodone. Continue to take trazodone even if you feel well.
Do not stop taking trazodone without talking to your doctor. If you suddenly stop taking trazodone, you may experience withdrawal symptoms such as dizziness; nausea; headache; confusion; anxiety; agitation; difficulty falling asleep or staying asleep; extreme tiredness; seizures; pain, burning, or tingling in the hands or feet; frenzied or abnormally excited mood; ringing in the ears; or sweating. Your doctor will probably decrease your dose gradually.
Other uses for this medicine
Trazodone is also sometimes used to treat insomnia and schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions); anxiety (excessive worry). Trazodone is also sometimes used to control abnormal, uncontrollable movements that may be experienced as side effects of other medications and for the management of alcohol dependence. Talk to your doctor about the possible risks of using this medication for your condition.
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking trazodone,
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tell your doctor and pharmacist if you are allergic to trazodone or any other medications.
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tell your doctor if you are taking a monoamine oxidase (MAO) inhibitor, such as isocarboxazid (Marplan), linezolid, methylene blue, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), or if you have stopped taking one of these medications within the past 14 days. Your doctor will probably tell you that you should not take trazodone. If you stop taking trazodone, your doctor will tell you that you should wait at least 14 days before you start to take an MAO inhibitor.
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tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: amiodarone (Nexterone, Pacerone); anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); antifungals such as itraconazole (Sporanox, Tolsura), ketoconazole, or voriconazole (Vfend); aspirin and other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); buspirone; carbamazepine (Carbatrol, Equetro, Tegretol, others); chlorpromazine; clarithromycin (Biaxin); clopidogrel (Plavix); dabigatran (Pradaxa); digoxin (Lanoxin); disopyramide (Norpace); diuretics ('water pills'); fentanyl (Actiq, Duragesic, Fentora, Subsys); indinavir (Crixivan); lithium (Lithobid); medications for anxiety, irregular heartbeat, mental illness or pain; medications for migraine headaches such as almotriptan, eletriptan (Relpax), frovatriptan (Frova), naratriptan, rizatriptan (Maxalt), and sumatriptan (Imitrex); phenobarbital; phenytoin (Dilantin, Phenytek); procainamide; quinidine (in Nuedexta); rifampin (Rifadin, Rimactane); rivaroxaban (Xarelto);sedatives; selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac), fluvoxamine (Luvox), paroxetine (Paxil, Pexeva), and sertraline (Zoloft); tranquilizers; sotalol (Betapace, Sorine, Sotylize); thioridazine; tramadol (Conzip, Qdola, Ultram, in Ultracet); tricyclic antidepressants such as amitriptyline, amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline, and trimipramine; or ziprasidone (Geodon). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with trazodone, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
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tell your doctor what herbal products and nutritional supplements you are taking, especially St. John's wort and tryptophan.
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tell your doctor if you or anyone in your family has or has ever had long QT syndrome (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death), if you have ever had a heart attack, or if you have a low level of sodium in your blood. Also tell your doctor if you drink or have ever drunk large amounts of alcohol, or if you have or have ever had high blood pressure; bleeding problems; sickle cell anemia (a disease of the red blood cells); multiple myeloma (cancer of the plasma cells); leukemia (cancer of the white blood cells); cavernosal fibrosis or Peyronie's disease (conditions that affects the shape of the penis such as angulation); or heart, liver, or kidney disease.
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tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking trazodone, call your doctor.
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if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking trazodone.
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you should know that trazodone may make you drowsy and affect your judgment, thinking, and movements. Do not drive a car or operate machinery until you know how this medication affects you.
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ask your doctor about the safe use of alcoholic beverages while you are taking trazodone. Alcohol can make the side effects from trazodone worse.
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you should know that trazodone may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.
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you should know that trazodone may cause angle-closure glaucoma (a condition where the fluid is suddenly blocked and unable to flow out of the eye causing a quick, severe increase in eye pressure which may lead to a loss of vision). Talk to your doctor about having an eye examination before you start taking this medication. If you have nausea, eye pain, changes in vision, such as seeing colored rings around lights, and swelling or redness in or around the eye, call your doctor or get emergency medical treatment right away.
What special dietary instructions should I follow?
Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
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Trazodone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
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nausea
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vomiting
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diarrhea
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constipation
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changes in appetite or weight
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weakness or tiredness
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nervousness
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dizziness or lightheadedness
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nightmares
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muscle pain
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dry mouth
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rash
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sexual problems in males; decreased sex drive, inability to get or keep an erection, or delayed or absent ejaculation
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sexual problems in females; decreased sex drive, or delayed orgasm or unable to have an orgasm
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uncontrollable shaking of a part of the body
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stuffy nose
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tired, red, or itchy eyes
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Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS sections, call your doctor immediately or get emergency medical treatment:
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chest pain
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fast, pounding, or irregular heartbeat
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loss of consciousness (coma)
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fever, sweating, confusion, fast or irregular heartbeat, and severe muscle stiffness or twitching, agitation, hallucinations, loss of coordination, nausea, vomiting, or diarrhea
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fainting
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seizures
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shortness of breath
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unusual bruising or bleeding
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nosebleeds
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small red or purple dots on the skin
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erection lasting more than 6 hours
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headache
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problems with thinking, concentration, or memory
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weakness
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problems with coordination
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Trazodone can cause painful, long lasting erections in males. In some cases emergency and/or surgical treatment has been required and, in some of these cases, permanent damage has occurred. Talk to your doctor about the risk of taking trazodone.
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Trazodone may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
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If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I know about STORAGE and DISPOSAL of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat, and moisture (not in the bathroom).
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Symptoms of overdose may include:
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vomiting
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drowsiness
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changes in heartbeat
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seizures
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difficulty breathing
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painful erection that does not go away
What OTHER INFORMATION should I know?
Keep all appointments with your doctor.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Drug interactions
Drug | Interaction |
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Moxifloxacin | Moxifloxacin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Moxifloxacin. |
Delavirdine | Delavirdine The serum concentration of Trazodone can be increased when it is combined with Delavirdine. |
Nevirapine | Nevirapine The metabolism of Trazodone can be decreased when combined with Nevirapine. |
Atorvastatin | Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Trazodone. |
Dolasetron | Dolasetron The risk or severity of QTc prolongation can be increased when Trazodone is combined with Dolasetron. |
Anagrelide | Anagrelide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Anagrelide. |
Candesartan | Candesartan Trazodone may decrease the antihypertensive activities of Candesartan. |
Cilostazol | Cilostazol The risk or severity of QTc prolongation can be increased when Trazodone is combined with Cilostazol. |
Clopidogrel | Clopidogrel The risk or severity of bleeding can be increased when Trazodone is combined with Clopidogrel. |
Diphenoxylate | Diphenoxylate The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Diphenoxylate. |
Erythromycin and Sulfisoxazole | Erythromycin and Sulfisoxazole The risk or severity of QTc prolongation can be increased when Trazodone is combined with Erythromycin. |
Guanfacine | Guanfacine The risk or severity of adverse effects can be increased when Guanfacine is combined with Trazodone. |
Methylergonovine | Methylergonovine The risk or severity of hypertension can be increased when Methylergometrine is combined with Trazodone. |
Naratriptan | Naratriptan The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Naratriptan. |
Olsalazine | Olsalazine The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Olsalazine. |
Paregoric | Paregoric The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Morphine. |
Penbutolol | Penbutolol The risk or severity of QTc prolongation can be increased when Trazodone is combined with Acebutolol. |
Pentazocine | Pentazocine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Pentazocine. |
Ranitidine | Ranitidine The metabolism of Trazodone can be decreased when combined with Ranitidine. |
Reserpine | Reserpine The risk or severity of adverse effects can be increased when Reserpine is combined with Trazodone. |
Rizatriptan | Rizatriptan The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Rizatriptan. |
Sumatriptan | Sumatriptan The risk or severity of adverse effects can be increased when Sumatriptan is combined with Trazodone. |
Tacrolimus | Tacrolimus The risk or severity of QTc prolongation can be increased when Trazodone is combined with Tacrolimus. |
Tizanidine | Tizanidine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Tizanidine. |
Triamcinolone | Triamcinolone The metabolism of Trazodone can be increased when combined with Triamcinolone. |
Zolmitriptan | Zolmitriptan The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Zolmitriptan. |
Famotidine Injection | Famotidine Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Famotidine. |
Fluconazole Injection | Fluconazole Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Fluconazole. |
Foscarnet Injection | Foscarnet Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Foscarnet. |
Hydromorphone Injection | Hydromorphone Injection The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Hydromorphone. |
Levofloxacin Injection | Levofloxacin Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Levofloxacin. |
Meperidine Injection | Meperidine Injection The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Meperidine. |
Metoclopramide Injection | Metoclopramide Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Metoclopramide. |
Metronidazole Injection | Metronidazole Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Metronidazole. |
Morphine Injection | Morphine Injection The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Morphine. |
Altretamine | Altretamine Amphetamine may increase the serotonergic activities of Trazodone. |
Cyclosporine | Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Trazodone. |
Ondansetron | Ondansetron The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ondansetron. |
Enoxaparin Injection | Enoxaparin Injection The risk or severity of bleeding can be increased when Trazodone is combined with Enoxaparin. |
Granisetron | Granisetron The risk or severity of QTc prolongation can be increased when Trazodone is combined with Granisetron. |
Torsemide | Torsemide Trazodone may decrease the antihypertensive activities of Torasemide. |
Olanzapine | Olanzapine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Olanzapine. |
Alosetron | Alosetron The risk or severity of adverse effects can be increased when Alosetron is combined with Trazodone. |
Dofetilide | Dofetilide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Dofetilide. |
Entacapone | Entacapone The risk or severity of adverse effects can be increased when Entacapone is combined with Trazodone. |
Eprosartan | Eprosartan Trazodone may decrease the antihypertensive activities of Eprosartan. |
Hydroxychloroquine | Hydroxychloroquine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Hydroxychloroquine. |
Meloxicam | Meloxicam The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Meloxicam. |
Oxcarbazepine | Oxcarbazepine The risk or severity of adverse effects can be increased when Oxcarbazepine is combined with Trazodone. |
Telmisartan | Telmisartan Trazodone may decrease the antihypertensive activities of Telmisartan. |
Zaleplon | Zaleplon The risk or severity of adverse effects can be increased when Zaleplon is combined with Trazodone. |
Anakinra | Anakinra The metabolism of Trazodone can be increased when combined with Anakinra. |
Desloratadine | Desloratadine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Desloratadine. |
Linezolid | Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Trazodone. |
Pentosan Polysulfate | Pentosan Polysulfate The risk or severity of bleeding can be increased when Trazodone is combined with Pentosan polysulfate. |
Trimipramine | Trimipramine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Trimipramine. |
Etanercept Injection | Etanercept Injection The metabolism of Trazodone can be increased when combined with Etanercept. |
Glycopyrrolate | Glycopyrrolate Trazodone may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium. |
Modafinil | Modafinil The metabolism of Trazodone can be increased when combined with Modafinil. |
Perindopril | Perindopril Trazodone may decrease the antihypertensive activities of Perindopril. |
Choline Magnesium Trisalicylate | Choline Magnesium Trisalicylate The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Choline magnesium trisalicylate. |
Sirolimus | Sirolimus The metabolism of Sirolimus can be decreased when combined with Trazodone. |
Dutasteride | Dutasteride The metabolism of Dutasteride can be decreased when combined with Trazodone. |
Epinephrine Injection | Epinephrine Injection The therapeutic efficacy of Epinephrine can be decreased when used in combination with Trazodone. |
Eplerenone | Eplerenone The metabolism of Eplerenone can be decreased when combined with Trazodone. |
Escitalopram | Escitalopram The risk or severity of QTc prolongation can be increased when Trazodone is combined with Escitalopram. |
Olmesartan | Olmesartan Trazodone may decrease the antihypertensive activities of Olmesartan. |
Zonisamide | Zonisamide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Zonisamide. |
Adalimumab Injection | Adalimumab Injection The metabolism of Trazodone can be increased when combined with Adalimumab. |
Aripiprazole | Aripiprazole The risk or severity of QTc prolongation can be increased when Trazodone is combined with Aripiprazole. |
Atomoxetine | Atomoxetine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Atomoxetine. |
Dexmethylphenidate | Dexmethylphenidate The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Dexmethylphenidate. |
Teriparatide Injection | Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Trazodone. |
Atazanavir | Atazanavir The risk or severity of QTc prolongation can be increased when Trazodone is combined with Atazanavir. |
Almotriptan | Almotriptan The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Almotriptan. |
Eletriptan | Eletriptan The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Eletriptan. |
Mefloquine | Mefloquine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Mefloquine. |
Rosuvastatin | Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Trazodone. |
Vardenafil | Vardenafil The risk or severity of QTc prolongation can be increased when Trazodone is combined with Vardenafil. |
Alfuzosin | Alfuzosin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Alfuzosin. |
Aprepitant | Aprepitant The metabolism of Trazodone can be decreased when combined with Aprepitant. |
Tegaserod | Tegaserod The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Tegaserod. |
Tadalafil | Tadalafil The risk or severity of hypotension, dyspepsia, and headache can be increased when Trazodone is combined with Tadalafil. |
Frovatriptan | Frovatriptan The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Frovatriptan. |
Gemifloxacin | Gemifloxacin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Gemifloxacin. |
Progesterone | Progesterone The metabolism of Trazodone can be decreased when combined with Progesterone. |
Apomorphine Injection | Apomorphine Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Apomorphine. |
Infliximab Injection | Infliximab Injection The metabolism of Trazodone can be increased when combined with Infliximab. |
Protriptyline | Protriptyline The risk or severity of QTc prolongation can be increased when Trazodone is combined with Protriptyline. |
Rifaximin | Rifaximin The serum concentration of Trazodone can be decreased when it is combined with Rifaximin. |
Duloxetine | Duloxetine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Duloxetine. |
Norethindrone | Norethindrone The metabolism of Norethisterone can be decreased when combined with Trazodone. |
Trospium | Trospium Trazodone may increase the central nervous system depressant (CNS depressant) activities of Trospium. |
Bosentan | Bosentan Trazodone may decrease the antihypertensive activities of Bosentan. |
Cinacalcet | Cinacalcet The metabolism of Trazodone can be decreased when combined with Cinacalcet. |
Erlotinib | Erlotinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Erlotinib. |
Eszopiclone | Eszopiclone The risk or severity of CNS depression can be increased when Trazodone is combined with Eszopiclone. |
Solifenacin | Solifenacin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Solifenacin. |
Voriconazole | Voriconazole The risk or severity of QTc prolongation can be increased when Trazodone is combined with Voriconazole. |
Dextroamphetamine | Dextroamphetamine Amphetamine may increase the serotonergic activities of Trazodone. |
Peginterferon Alfa-2b (PEG-Intron) | Peginterferon Alfa-2b (PEG-Intron) The metabolism of Trazodone can be decreased when combined with Peginterferon alfa-2b. |
Sodium Oxybate | Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Trazodone. |
Ibandronate | Ibandronate The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ibandronate. |
Isocarboxazid | Isocarboxazid Isocarboxazid may increase the serotonergic activities of Trazodone. |
Ramelteon | Ramelteon The risk or severity of adverse effects can be increased when Ramelteon is combined with Trazodone. |
Darifenacin | Darifenacin The metabolism of Darifenacin can be decreased when combined with Trazodone. |
Fentanyl | Fentanyl The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Fentanyl. |
Pregabalin | Pregabalin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Pregabalin. |
Phenylephrine | Phenylephrine The therapeutic efficacy of Phenylephrine can be decreased when used in combination with Trazodone. |
Tipranavir | Tipranavir The serum concentration of Tipranavir can be increased when it is combined with Trazodone. |
Felbamate | Felbamate The risk or severity of QTc prolongation can be increased when Trazodone is combined with Felbamate. |
Ranolazine | Ranolazine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ranolazine. |
Abatacept Injection | Abatacept Injection The metabolism of Trazodone can be increased when combined with Abatacept. |
Rasagiline | Rasagiline Rasagiline may increase the serotonergic activities of Trazodone. |
Imatinib | Imatinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Imatinib. |
Gefitinib | Gefitinib The metabolism of Trazodone can be decreased when combined with Gefitinib. |
Albuterol | Albuterol The risk or severity of QTc prolongation can be increased when Trazodone is combined with Salbutamol. |
Paliperidone | Paliperidone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Paliperidone. |
Bortezomib | Bortezomib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Bortezomib. |
Oxaliplatin Injection | Oxaliplatin Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Oxaliplatin. |
Posaconazole | Posaconazole The risk or severity of QTc prolongation can be increased when Trazodone is combined with Posaconazole. |
Primaquine | Primaquine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Primaquine. |
Aliskiren | Aliskiren Trazodone may decrease the antihypertensive activities of Aliskiren. |
Darunavir | Darunavir The serum concentration of Trazodone can be increased when it is combined with Darunavir. |
Dimenhydrinate | Dimenhydrinate The risk or severity of QTc prolongation can be increased when Trazodone is combined with Dimenhydrinate. |
Lisdexamfetamine | Lisdexamfetamine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Lisdexamfetamine. |
Nabilone | Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Trazodone. |
Vorinostat | Vorinostat The risk or severity of QTc prolongation can be increased when Trazodone is combined with Vorinostat. |
Sorafenib | Sorafenib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Sorafenib. |
Sunitinib | Sunitinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Sunitinib. |
Dronabinol | Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Trazodone. |
Lapatinib | Lapatinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Lapatinib. |
Levocetirizine | Levocetirizine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Levocetirizine. |
Dasatinib | Dasatinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Dasatinib. |
Mexiletine | Mexiletine The metabolism of Mexiletine can be decreased when combined with Trazodone. |
Armodafinil | Armodafinil The metabolism of Trazodone can be increased when combined with Armodafinil. |
Temsirolimus | Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Trazodone. |
Nilotinib | Nilotinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Nilotinib. |
Toremifene | Toremifene The risk or severity of QTc prolongation can be increased when Trazodone is combined with Toremifene. |
Budesonide | Budesonide The metabolism of Trazodone can be increased when combined with Budesonide. |
Chloramphenicol Injection | Chloramphenicol Injection The metabolism of Trazodone can be decreased when combined with Chloramphenicol. |
Desmopressin | Desmopressin The risk or severity of hyponatremia can be increased when Trazodone is combined with Desmopressin. |
OnabotulinumtoxinA Injection | OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Trazodone. |
RimabotulinumtoxinB Injection | RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Botulinum Toxin Type B is combined with Trazodone. |
Arsenic Trioxide Injection | Arsenic Trioxide Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Arsenic trioxide. |
Desvenlafaxine | Desvenlafaxine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Desvenlafaxine. |
Cevimeline | Cevimeline The metabolism of Cevimeline can be decreased when combined with Trazodone. |
Nebivolol | Nebivolol The serum concentration of Nebivolol can be increased when it is combined with Trazodone. |
Tretinoin | Tretinoin The metabolism of Tretinoin can be decreased when combined with Trazodone. |
Bendamustine Injection | Bendamustine Injection The serum concentration of Bendamustine can be decreased when it is combined with Trazodone. |
Flecainide | Flecainide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Flecainide. |
Certolizumab Injection | Certolizumab Injection The metabolism of Trazodone can be increased when combined with Certolizumab pegol. |
Irinotecan Injection | Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Trazodone. |
Praziquantel | Praziquantel The metabolism of Praziquantel can be decreased when combined with Trazodone. |
Mitotane | Mitotane The serum concentration of Trazodone can be decreased when it is combined with Mitotane. |
Rufinamide | Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Trazodone. |
Silodosin | Silodosin Trazodone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Silodosin. |
Midazolam | Midazolam The risk or severity of adverse effects can be increased when Trazodone is combined with Midazolam. |
Naltrexone Injection | Naltrexone Injection The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Naltrexone. |
Milnacipran | Milnacipran The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Milnacipran. |
Fesoterodine | Fesoterodine Trazodone may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine. |
Degarelix Injection | Degarelix Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Degarelix. |
Betaxolol | Betaxolol The risk or severity of QTc prolongation can be increased when Trazodone is combined with Betaxolol. |
Iloperidone | Iloperidone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Iloperidone. |
Prasugrel | Prasugrel The risk or severity of bleeding can be increased when Trazodone is combined with Prasugrel. |
Lacosamide | Lacosamide The risk or severity of adverse effects can be increased when Lacosamide is combined with Trazodone. |
Everolimus | Everolimus The serum concentration of Trazodone can be decreased when it is combined with Everolimus. |
Tolvaptan (low blood sodium) | Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be decreased when it is combined with Trazodone. |
Dronedarone | Dronedarone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Dronedarone. |
AbobotulinumtoxinA Injection | AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Trazodone. |
Palonosetron Injection | Palonosetron Injection The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Palonosetron. |
Saxagliptin | Saxagliptin The metabolism of Saxagliptin can be decreased when combined with Trazodone. |
Telavancin Injection | Telavancin Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Telavancin. |
Romidepsin Injection | Romidepsin Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Romidepsin. |
Tapentadol | Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Trazodone. |
Topotecan | Topotecan The serum concentration of Topotecan can be decreased when it is combined with Trazodone. |
Golimumab Injection | Golimumab Injection The metabolism of Trazodone can be increased when combined with Golimumab. |
Pazopanib | Pazopanib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Pazopanib. |
Asenapine | Asenapine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Asenapine. |
Vigabatrin | Vigabatrin The risk or severity of adverse effects can be increased when Vigabatrin is combined with Trazodone. |
Levonorgestrel | Levonorgestrel The metabolism of Trazodone can be decreased when combined with Levonorgestrel. |
Oxymorphone | Oxymorphone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Oxymorphone. |
Dabigatran | Dabigatran The risk or severity of bleeding can be increased when Trazodone is combined with Dabigatran. |
Tocilizumab Injection | Tocilizumab Injection The metabolism of Trazodone can be increased when combined with Tocilizumab. |
Dalfampridine | Dalfampridine The risk or severity of seizure can be increased when Trazodone is combined with Dalfampridine. |
Fingolimod | Fingolimod The risk or severity of QTc prolongation can be increased when Trazodone is combined with Fingolimod. |
Eribulin Injection | Eribulin Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Eribulin. |
IncobotulinumtoxinA Injection | IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Trazodone. |
Cabazitaxel Injection | Cabazitaxel Injection The serum concentration of Cabazitaxel can be decreased when it is combined with Trazodone. |
Lurasidone | Lurasidone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Lurasidone. |
Acetaminophen Injection | Acetaminophen Injection The metabolism of Acetaminophen can be decreased when combined with Trazodone. |
Vilazodone | Vilazodone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Vilazodone. |
Terbutaline Injection | Terbutaline Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Terbutaline. |
Linagliptin | Linagliptin The serum concentration of Linagliptin can be decreased when it is combined with Trazodone. |
Rilpivirine | Rilpivirine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Rilpivirine. |
Potassium Iodide | Potassium Iodide The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Trazodone. |
Cyclophosphamide Injection | Cyclophosphamide Injection The metabolism of Trazodone can be decreased when combined with Cyclophosphamide. |
Abiraterone | Abiraterone The metabolism of Trazodone can be decreased when combined with Abiraterone. |
Triptorelin Injection | Triptorelin Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Triptorelin. |
Rivaroxaban | Rivaroxaban The risk or severity of bleeding can be increased when Trazodone is combined with Rivaroxaban. |
Ticagrelor | Ticagrelor The risk or severity of bleeding can be increased when Trazodone is combined with Ticagrelor. |
Brentuximab Vedotin Injection | Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be decreased when it is combined with Trazodone. |
Vandetanib | Vandetanib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Vandetanib. |
Clobazam | Clobazam The metabolism of Trazodone can be decreased when combined with Clobazam. |
Vemurafenib | Vemurafenib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Vemurafenib. |
Ivacaftor | Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Trazodone. |
Axitinib | Axitinib The serum concentration of Axitinib can be decreased when it is combined with Trazodone. |
Crizotinib | Crizotinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Crizotinib. |
Cabergoline | Cabergoline The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Cabergoline. |
Naloxone Injection | Naloxone Injection The serum concentration of Trazodone can be increased when it is combined with Naloxone. |
Ambrisentan | Ambrisentan The metabolism of Ambrisentan can be decreased when combined with Trazodone. |
Fondaparinux Injection | Fondaparinux Injection The risk or severity of bleeding can be increased when Trazodone is combined with Fondaparinux. |
Ezogabine | Ezogabine The risk or severity of adverse effects can be increased when Tiagabine is combined with Trazodone. |
Carfilzomib Injection | Carfilzomib Injection The serum concentration of Carfilzomib can be decreased when it is combined with Trazodone. |
Iloprost | Iloprost The risk or severity of bleeding can be increased when Trazodone is combined with Iloprost. |
Enzalutamide | Enzalutamide The serum concentration of Trazodone can be decreased when it is combined with Enzalutamide. |
Mirabegron | Mirabegron The risk or severity of QTc prolongation can be increased when Trazodone is combined with Mirabegron. |
Regorafenib | Regorafenib The serum concentration of Regorafenib can be decreased when it is combined with Trazodone. |
Bosutinib | Bosutinib The serum concentration of Bosutinib can be decreased when it is combined with Trazodone. |
Bedaquiline | Bedaquiline The risk or severity of QTc prolongation can be increased when Trazodone is combined with Bedaquiline. |
Icosapent Ethyl | Icosapent Ethyl The risk or severity of bleeding can be increased when Trazodone is combined with Icosapent ethyl. |
Alogliptin | Alogliptin The metabolism of Alogliptin can be decreased when combined with Trazodone. |
Ponatinib | Ponatinib The metabolism of Ponatinib can be decreased when combined with Trazodone. |
Pomalidomide | Pomalidomide The serum concentration of Trazodone can be decreased when it is combined with Pomalidomide. |
Ado-trastuzumab Emtansine Injection | Ado-trastuzumab Emtansine Injection The serum concentration of Trastuzumab emtansine can be decreased when it is combined with Trazodone. |
Apixaban | Apixaban The risk or severity of bleeding can be increased when Trazodone is combined with Apixaban. |
Dabrafenib | Dabrafenib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Dabrafenib. |
Ospemifene | Ospemifene The metabolism of Trazodone can be decreased when combined with Ospemifene. |
Afatinib | Afatinib The serum concentration of Afatinib can be decreased when it is combined with Trazodone. |
Levomilnacipran | Levomilnacipran The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Levomilnacipran. |
Vortioxetine | Vortioxetine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Vortioxetine. |
Perampanel | Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Trazodone. |
Ibrutinib | Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Trazodone. |
Avanafil | Avanafil The risk or severity of hypotension, dyspepsia, and headache can be increased when Avanafil is combined with Trazodone. |
Ketorolac Injection | Ketorolac Injection The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Ketorolac. |
Sofosbuvir | Sofosbuvir The serum concentration of Sofosbuvir can be decreased when it is combined with Trazodone. |
Dapagliflozin | Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Trazodone. |
Apremilast | Apremilast The metabolism of Trazodone can be increased when combined with Apremilast. |
Droxidopa | Droxidopa The therapeutic efficacy of Droxidopa can be decreased when used in combination with Trazodone. |
Ceritinib | Ceritinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ceritinib. |
Siltuximab Injection | Siltuximab Injection The metabolism of Trazodone can be increased when combined with Siltuximab. |
Eslicarbazepine | Eslicarbazepine The risk or severity of adverse effects can be increased when Eslicarbazepine is combined with Trazodone. |
Testosterone Injection | Testosterone Injection The metabolism of Trazodone can be decreased when combined with Testosterone. |
Oritavancin Injection | Oritavancin Injection The metabolism of Trazodone can be decreased when combined with Oritavancin. |
Vorapaxar | Vorapaxar The risk or severity of bleeding can be increased when Trazodone is combined with Vorapaxar. |
Hydrocodone | Hydrocodone Hydrocodone may increase the central nervous system depressant (CNS depressant) activities of Trazodone. |
Suvorexant | Suvorexant Trazodone may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
Edoxaban | Edoxaban The risk or severity of bleeding can be increased when Trazodone is combined with Edoxaban. |
Olaparib | Olaparib The metabolism of Olaparib can be decreased when combined with Trazodone. |
Methamphetamine | Methamphetamine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Metamfetamine. |
Tasimelteon | Tasimelteon The risk or severity of adverse effects can be increased when Tasimelteon is combined with Trazodone. |
Riociguat | Riociguat Trazodone may decrease the antihypertensive activities of Riociguat. |
Secukinumab Injection | Secukinumab Injection The metabolism of Trazodone can be increased when combined with Secukinumab. |
Risperidone Injection | Risperidone Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Risperidone. |
Lenvatinib | Lenvatinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Lenvatinib. |
Naloxegol | Naloxegol The metabolism of Trazodone can be decreased when combined with Naloxegol. |
Panobinostat | Panobinostat The risk or severity of QTc prolongation can be increased when Trazodone is combined with Panobinostat. |
Haloperidol Injection | Haloperidol Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Haloperidol. |
Ivabradine | Ivabradine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ivabradine. |
Macitentan | Macitentan Trazodone may decrease the antihypertensive activities of Macitentan. |
Flibanserin | Flibanserin The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Flibanserin. |
Rolapitant | Rolapitant The metabolism of Trazodone can be decreased when combined with Rolapitant. |
Daclatasvir | Daclatasvir The metabolism of Daclatasvir can be decreased when combined with Trazodone. |
Brexpiprazole | Brexpiprazole The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Brexpiprazole. |
Ziprasidone Injection | Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ziprasidone. |
Cariprazine | Cariprazine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Cariprazine. |
Eluxadoline | Eluxadoline The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Eluxadoline. |
Cobimetinib | Cobimetinib The serum concentration of Cobimetinib can be decreased when it is combined with Trazodone. |
Trabectedin Injection | Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Trazodone. |
Osimertinib | Osimertinib The serum concentration of Osimertinib can be decreased when it is combined with Trazodone. |
Dexamethasone Injection | Dexamethasone Injection The serum concentration of Trazodone can be decreased when it is combined with Dexamethasone. |
Defibrotide Injection | Defibrotide Injection The risk or severity of bleeding can be increased when Trazodone is combined with Defibrotide. |
Brivaracetam Injection | Brivaracetam Injection The risk or severity of adverse effects can be increased when Brivaracetam is combined with Trazodone. |
Venetoclax | Venetoclax The serum concentration of Venetoclax can be decreased when it is combined with Trazodone. |
Cobicistat | Cobicistat The serum concentration of Trazodone can be increased when it is combined with Cobicistat. |
Midodrine | Midodrine The therapeutic efficacy of Midodrine can be decreased when used in combination with Trazodone. |
Selexipag | Selexipag Trazodone may decrease the antihypertensive activities of Selexipag. |
Pimavanserin | Pimavanserin The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Pimavanserin. |
Diphenhydramine Injection | Diphenhydramine Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Diphenhydramine. |
Furosemide Injection | Furosemide Injection Trazodone may decrease the antihypertensive activities of Furosemide. |
Rucaparib | Rucaparib The metabolism of Trazodone can be decreased when combined with Rucaparib. |
Ribociclib | Ribociclib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ribociclib. |
Parathyroid Hormone Injection | Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Trazodone. |
Doxepin (Insomnia) | Doxepin (Insomnia) The risk or severity of QTc prolongation can be increased when Trazodone is combined with Doxepin. |
Deutetrabenazine | Deutetrabenazine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Deutetrabenazine. |
Valbenazine | Valbenazine The metabolism of Valbenazine can be decreased when combined with Trazodone. |
Deflazacort | Deflazacort The metabolism of Trazodone can be increased when combined with Deflazacort. |
Safinamide | Safinamide Safinamide may increase the serotonergic activities of Trazodone. |
Midostaurin | Midostaurin The serum concentration of Trazodone can be increased when it is combined with Midostaurin. |
Abaloparatide Injection | Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Trazodone. |
Enasidenib | Enasidenib The metabolism of Enasidenib can be decreased when combined with Trazodone. |
Inotuzumab Ozogamicin Injection | Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be decreased when it is combined with Trazodone. |
Copanlisib Injection | Copanlisib Injection The serum concentration of Copanlisib can be decreased when it is combined with Trazodone. |
Delafloxacin | Delafloxacin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Delafloxacin. |
Abemaciclib | Abemaciclib The serum concentration of Abemaciclib can be decreased when it is combined with Trazodone. |
Betrixaban | Betrixaban The risk or severity of bleeding can be increased when Trazodone is combined with Betrixaban. |
Acalabrutinib | Acalabrutinib The metabolism of Trazodone can be decreased when combined with Acalabrutinib. |
Letermovir | Letermovir The metabolism of Trazodone can be decreased when combined with Letermovir. |
Tetrabenazine | Tetrabenazine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Tetrabenazine. |
Buprenorphine Injection | Buprenorphine Injection Trazodone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. |
Apalutamide | Apalutamide The serum concentration of Trazodone can be decreased when it is combined with Apalutamide. |
Fostamatinib | Fostamatinib The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Trazodone. |
Lofexidine | Lofexidine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Lofexidine. |
Eliglustat | Eliglustat The risk or severity of QTc prolongation can be increased when Trazodone is combined with Eliglustat. |
Encorafenib | Encorafenib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Encorafenib. |
Binimetinib | Binimetinib The serum concentration of Binimetinib can be decreased when it is combined with Trazodone. |
Ivosidenib | Ivosidenib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ivosidenib. |
Elagolix | Elagolix The metabolism of Elagolix can be decreased when combined with Trazodone. |
Doravirine | Doravirine The metabolism of Doravirine can be decreased when combined with Trazodone. |
Tafenoquine | Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Trazodone. |
Cannabidiol | Cannabidiol The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Cannabidiol. |
Dacomitinib | Dacomitinib The serum concentration of Trazodone can be decreased when it is combined with Dacomitinib. |
Stiripentol | Stiripentol The serum concentration of Trazodone can be increased when it is combined with Stiripentol. |
Talazoparib | Talazoparib The serum concentration of Talazoparib can be decreased when it is combined with Trazodone. |
Gilteritinib | Gilteritinib The therapeutic efficacy of Trazodone can be decreased when used in combination with Gilteritinib. |
Glasdegib | Glasdegib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Glasdegib. |
Lorlatinib | Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Trazodone. |
Paclitaxel (with albumin) Injection | Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Trazodone. |
Rifamycin | Rifamycin The serum concentration of Trazodone can be decreased when it is combined with Rifamycin. |
Emapalumab-lzsg Injection | Emapalumab-lzsg Injection The metabolism of Trazodone can be increased when combined with Emapalumab. |
Siponimod | Siponimod The risk or severity of hypertension can be increased when Trazodone is combined with Siponimod. |
Caplacizumab-yhdp Injection | Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Trazodone is combined with Caplacizumab. |
Brexanolone Injection | Brexanolone Injection The risk or severity of adverse effects can be increased when Brexanolone is combined with Trazodone. |
Solriamfetol | Solriamfetol The risk or severity of hypertension can be increased when Solriamfetol is combined with Trazodone. |
Triclabendazole | Triclabendazole The risk or severity of QTc prolongation can be increased when Trazodone is combined with Triclabendazole. |
Entrectinib | Entrectinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Entrectinib. |
Istradefylline | Istradefylline The metabolism of Istradefylline can be decreased when combined with Trazodone. |
Pitolisant | Pitolisant The therapeutic efficacy of Pitolisant can be decreased when used in combination with Trazodone. |
Fedratinib | Fedratinib The metabolism of Trazodone can be decreased when combined with Fedratinib. |
Lefamulin | Lefamulin Trazodone may increase the QTc-prolonging activities of Lefamulin. |
Phenytoin Injection | Phenytoin Injection The serum concentration of Phenytoin can be increased when it is combined with Trazodone. |
Fosphenytoin Injection | Fosphenytoin Injection The serum concentration of Fosphenytoin can be increased when it is combined with Trazodone. |
Lumateperone | Lumateperone The risk or severity of adverse effects can be increased when Lumateperone is combined with Trazodone. |
Lasmiditan | Lasmiditan The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Lasmiditan. |
Cenobamate | Cenobamate The serum concentration of Trazodone can be decreased when it is combined with Cenobamate. |
Selumetinib | Selumetinib The metabolism of Selumetinib can be decreased when combined with Trazodone. |
Tucatinib | Tucatinib The metabolism of Tucatinib can be decreased when combined with Trazodone. |
Selpercatinib | Selpercatinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Selpercatinib. |
Lemborexant | Lemborexant The risk or severity of adverse effects can be increased when Trazodone is combined with Lemborexant. |
Daratumumab and Hyaluronidase-fihj Injection | Daratumumab and Hyaluronidase-fihj Injection The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Trazodone. |
Fenfluramine | Fenfluramine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Fenfluramine. |
Fostemsavir | Fostemsavir The risk or severity of QTc prolongation can be increased when Trazodone is combined with Fostemsavir. |
Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf Injection | Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf Injection The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Trazodone. |
Octreotide | Octreotide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Octreotide. |
Pralsetinib | Pralsetinib The metabolism of Trazodone can be decreased when combined with Pralsetinib. |
Satralizumab-mwge Injection | Satralizumab-mwge Injection The serum concentration of Trazodone can be decreased when it is combined with Satralizumab. |
Naxitamab-gqgk Injection | Naxitamab-gqgk Injection The risk or severity of hypertension can be increased when Trazodone is combined with Naxitamab. |
Relugolix | Relugolix The serum concentration of Relugolix can be decreased when it is combined with Trazodone. |
Viloxazine | Viloxazine The risk or severity of adverse effects can be increased when Trazodone is combined with Viloxazine. |
Theophylline | Theophylline The metabolism of Theophylline can be decreased when combined with Trazodone. |
Fenoprofen | Fenoprofen The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Fenoprofen. |
Indomethacin | Indomethacin The risk or severity of gastrointestinal bleeding can be increased when Indomethacin is combined with Trazodone. |
Mefenamic Acid | Mefenamic Acid The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Mefenamic acid. |
Naproxen | Naproxen The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Naproxen. |
Tolmetin | Tolmetin The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Tolmetin. |
Sulindac | Sulindac The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Sulindac. |
Hydroxyurea | Hydroxyurea The metabolism of Trazodone can be decreased when combined with Hydroxyurea. |
Phenobarbital | Phenobarbital The serum concentration of Trazodone can be decreased when it is combined with Phenobarbital. |
Metaxalone | Metaxalone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Metaxalone. |
Levorphanol | Levorphanol The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Levorphanol. |
Primidone | Primidone The serum concentration of Trazodone can be decreased when it is combined with Primidone. |
Methsuximide | Methsuximide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Methsuximide. |
Diethylpropion | Diethylpropion The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Diethylpropion. |
Chlorpromazine | Chlorpromazine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Chlorpromazine. |
Diazepam | Diazepam The risk or severity of adverse effects can be increased when Trazodone is combined with Diazepam. |
Oxazepam | Oxazepam The risk or severity of adverse effects can be increased when Trazodone is combined with Oxazepam. |
Flurazepam | Flurazepam The risk or severity of adverse effects can be increased when Trazodone is combined with Flurazepam. |
Clorazepate | Clorazepate The risk or severity of adverse effects can be increased when Clorazepic acid is combined with Trazodone. |
Lorazepam | Lorazepam The risk or severity of adverse effects can be increased when Lorazepam is combined with Trazodone. |
Phenoxybenzamine | Phenoxybenzamine Trazodone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Phenoxybenzamine. |
Amantadine | Amantadine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Amantadine. |
Codeine | Codeine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Codeine. |
Meprobamate | Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Trazodone. |
Chlordiazepoxide | Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Trazodone. |
Bromocriptine | Bromocriptine Trazodone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Bromocriptine. |
Metaproterenol | Metaproterenol The therapeutic efficacy of Orciprenaline can be decreased when used in combination with Trazodone. |
Tranylcypromine | Tranylcypromine Tranylcypromine may increase the serotonergic activities of Trazodone. |
Phenelzine | Phenelzine Phenelzine may increase the serotonergic activities of Trazodone. |
Procarbazine | Procarbazine Procarbazine may increase the serotonergic activities of Trazodone. |
Ergoloid Mesylates | Ergoloid Mesylates The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Ergoloid mesylate. |
Minocycline | Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Trazodone. |
Prochlorperazine | Prochlorperazine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Prochlorperazine. |
Thioridazine | Thioridazine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Thioridazine. |
Trifluoperazine | Trifluoperazine Trazodone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Trifluoperazine. |
Dapsone | Dapsone The metabolism of Trazodone can be decreased when combined with Dapsone. |
Oxycodone | Oxycodone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Oxycodone. |
Methadone | Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Trazodone. |
Oxybutynin | Oxybutynin The metabolism of Oxybutynin can be decreased when combined with Trazodone. |
Benztropine | Benztropine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Benzatropine. |
Maprotiline | Maprotiline The risk or severity of QTc prolongation can be increased when Trazodone is combined with Maprotiline. |
Ibuprofen | Ibuprofen The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Ibuprofen. |
Trihexyphenidyl | Trihexyphenidyl Trazodone may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl. |
Orphenadrine | Orphenadrine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Orphenadrine. |
Perphenazine | Perphenazine The risk or severity of adverse effects can be increased when Trazodone is combined with Perphenazine. |
Fluphenazine | Fluphenazine The risk or severity of adverse effects can be increased when Fluphenazine is combined with Trazodone. |
Phentermine | Phentermine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Phentermine. |
Methylphenidate | Methylphenidate The risk or severity of hypertension can be increased when Methylphenidate is combined with Trazodone. |
Amoxapine | Amoxapine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Amoxapine. |
Sulfasalazine | Sulfasalazine The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Sulfasalazine. |
Hydrocortisone | Hydrocortisone The metabolism of Hydrocortisone can be decreased when combined with Trazodone. |
Doxorubicin | Doxorubicin The serum concentration of Doxorubicin can be decreased when it is combined with Trazodone. |
Dactinomycin | Dactinomycin The serum concentration of Dactinomycin can be decreased when it is combined with Trazodone. |
Carbamazepine | Carbamazepine The serum concentration of Trazodone can be decreased when it is combined with Carbamazepine. |
Molindone | Molindone The risk or severity of adverse effects can be increased when Trazodone is combined with Molindone. |
Methyldopa | Methyldopa The therapeutic efficacy of Methyldopa can be decreased when used in combination with Trazodone. |
Clonidine | Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Trazodone. |
Prazosin | Prazosin Prazosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Trazodone. |
Hydralazine | Hydralazine Trazodone may decrease the antihypertensive activities of Hydralazine. |
Cimetidine | Cimetidine The metabolism of Trazodone can be decreased when combined with Cimetidine. |
Warfarin | Warfarin Trazodone may decrease the anticoagulant activities of Warfarin. |
Clonazepam | Clonazepam The risk or severity of adverse effects can be increased when Clonazepam is combined with Trazodone. |
Loperamide | Loperamide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Loperamide. |
Promethazine | Promethazine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Promethazine. |
Meclofenamate | Meclofenamate The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Meclofenamic acid. |
Daunorubicin | Daunorubicin The metabolism of Trazodone can be increased when combined with Daunorubicin. |
Digoxin | Digoxin The serum concentration of Digoxin can be increased when it is combined with Trazodone. |
Loxapine | Loxapine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Loxapine. |
Chloroquine | Chloroquine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Chloroquine. |
Quinine | Quinine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Quinine. |
Ethosuximide | Ethosuximide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ethosuximide. |
Sulfinpyrazone | Sulfinpyrazone The risk or severity of bleeding can be increased when Trazodone is combined with Sulfinpyrazone. |
Chlorothiazide | Chlorothiazide The risk or severity of hyponatremia can be increased when Trazodone is combined with Chlorothiazide. |
Chlorthalidone | Chlorthalidone The risk or severity of hyponatremia can be increased when Trazodone is combined with Chlorthalidone. |
Metolazone | Metolazone The risk or severity of hyponatremia can be increased when Trazodone is combined with Metolazone. |
Clindamycin Injection | Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Trazodone. |
Secobarbital | Secobarbital The risk or severity of adverse effects can be increased when Secobarbital is combined with Trazodone. |
Desipramine | Desipramine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Desipramine. |
Amitriptyline | Amitriptyline The risk or severity of QTc prolongation can be increased when Trazodone is combined with Amitriptyline. |
Imipramine | Imipramine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Imipramine. |
Quinidine | Quinidine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Quinidine. |
Procainamide | Procainamide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Procainamide. |
Isoniazid | Isoniazid The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Isoniazid. |
Rifampin | Rifampin The serum concentration of Trazodone can be decreased when it is combined with Rifampicin. |
Disopyramide | Disopyramide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Disopyramide. |
Valproic Acid | Valproic Acid The risk or severity of QTc prolongation can be increased when Trazodone is combined with Valproic acid. |
Tamoxifen | Tamoxifen The risk or severity of QTc prolongation can be increased when Trazodone is combined with Tamoxifen. |
Butabarbital | Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Trazodone. |
Levothyroxine | Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Trazodone. |
Liothyronine | Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Trazodone. |
Methimazole | Methimazole The serum concentration of Trazodone can be increased when it is combined with Methimazole. |
Propylthiouracil | Propylthiouracil The therapeutic efficacy of Propylthiouracil can be decreased when used in combination with Trazodone. |
Dextromethorphan | Dextromethorphan The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Dextromethorphan. |
Cyclobenzaprine | Cyclobenzaprine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Cyclobenzaprine. |
Niacin | Niacin The metabolism of Trazodone can be decreased when combined with Niacin. |
Baclofen | Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Trazodone. |
Doxylamine | Doxylamine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Doxylamine. |
Cyproheptadine | Cyproheptadine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Cyproheptadine. |
Clemastine | Clemastine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Clemastine. |
Chlorpheniramine | Chlorpheniramine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Chlorpheniramine. |
Brompheniramine | Brompheniramine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Dexbrompheniramine. |
Meclizine | Meclizine The risk or severity of adverse effects can be increased when Meclizine is combined with Trazodone. |
Methyclothiazide | Methyclothiazide The risk or severity of hyponatremia can be increased when Trazodone is combined with Methyclothiazide. |
Hydrochlorothiazide | Hydrochlorothiazide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Hydrochlorothiazide. |
Dantrolene | Dantrolene The risk or severity of adverse effects can be increased when Dantrolene is combined with Trazodone. |
Chlorzoxazone | Chlorzoxazone The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Trazodone. |
Carisoprodol | Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Trazodone. |
Methocarbamol | Methocarbamol The risk or severity of adverse effects can be increased when Methocarbamol is combined with Trazodone. |
Disulfiram | Disulfiram The risk or severity of QTc prolongation can be increased when Trazodone is combined with Disulfiram. |
Propranolol (Cardiovascular) | Propranolol (Cardiovascular) The risk or severity of QTc prolongation can be increased when Trazodone is combined with Propranolol. |
Minoxidil | Minoxidil Trazodone may decrease the antihypertensive activities of Minoxidil. |
Pseudoephedrine | Pseudoephedrine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Pseudoephedrine. |
Nortriptyline | Nortriptyline The risk or severity of QTc prolongation can be increased when Trazodone is combined with Nortriptyline. |
Nadolol | Nadolol The serum concentration of Nadolol can be increased when it is combined with Trazodone. |
Butorphanol Injection | Butorphanol Injection The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Butorphanol. |
Nalbuphine Injection | Nalbuphine Injection The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Nalbuphine. |
Oxytocin Injection | Oxytocin Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Oxytocin. |
Trimethobenzamide | Trimethobenzamide The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Trazodone. |
Flavoxate | Flavoxate Trazodone may increase the central nervous system depressant (CNS depressant) activities of Flavoxate. |
Papaverine | Papaverine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Papaverine. |
Fluorouracil Injection | Fluorouracil Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Fluorouracil. |
Acetazolamide | Acetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Trazodone. |
Calcitonin Salmon Injection | Calcitonin Salmon Injection The therapeutic efficacy of Salmon calcitonin can be decreased when used in combination with Trazodone. |
Ketoconazole | Ketoconazole The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ketoconazole. |
Pyrantel | Pyrantel The risk or severity of adverse effects can be increased when Pyrantel is combined with Trazodone. |
Vincristine Injection | Vincristine Injection The serum concentration of Vincristine can be decreased when it is combined with Trazodone. |
Captopril | Captopril Trazodone may decrease the antihypertensive activities of Captopril. |
Dipyridamole | Dipyridamole The risk or severity of bleeding can be increased when Trazodone is combined with Dipyridamole. |
Isoxsuprine | Isoxsuprine The therapeutic efficacy of Isoxsuprine can be decreased when used in combination with Trazodone. |
Vinblastine | Vinblastine The serum concentration of Trazodone can be decreased when it is combined with Vinblastine. |
Metoprolol | Metoprolol The metabolism of Metoprolol can be decreased when combined with Trazodone. |
Hydroxyzine | Hydroxyzine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Hydroxyzine. |
Thiothixene | Thiothixene The risk or severity of QTc prolongation can be increased when Trazodone is combined with Thiothixene. |
Aspirin | Aspirin The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Acetylsalicylic acid. |
Salsalate | Salsalate The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Salsalate. |
Alprazolam | Alprazolam The risk or severity of adverse effects can be increased when Alprazolam is combined with Trazodone. |
Temazepam | Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Trazodone. |
Triazolam | Triazolam The risk or severity of adverse effects can be increased when Trazodone is combined with Triazolam. |
Dicyclomine | Dicyclomine Trazodone may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine. |
Hyoscyamine | Hyoscyamine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Hyoscyamine. |
Propantheline | Propantheline Trazodone may increase the central nervous system depressant (CNS depressant) activities of Propantheline. |
Diltiazem | Diltiazem The risk or severity of QTc prolongation can be increased when Trazodone is combined with Diltiazem. |
Nifedipine | Nifedipine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Nifedipine. |
Timolol | Timolol The risk or severity of QTc prolongation can be increased when Trazodone is combined with Timolol. |
Verapamil | Verapamil Verapamil may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Trazodone. |
Atenolol | Atenolol The serum concentration of Atenolol can be increased when it is combined with Trazodone. |
Pindolol | Pindolol The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Pindolol. |
Diflunisal | Diflunisal The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Diflunisal. |
Piroxicam | Piroxicam The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Piroxicam. |
Etoposide | Etoposide The serum concentration of Etoposide can be decreased when it is combined with Trazodone. |
Glyburide | Glyburide The metabolism of Glyburide can be decreased when combined with Trazodone. |
Indapamide | Indapamide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Indapamide. |
Pentoxifylline | Pentoxifylline The risk or severity of bleeding can be increased when Trazodone is combined with Pentoxifylline. |
Pentamidine Injection | Pentamidine Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Pentamidine. |
Labetalol | Labetalol Labetalol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Trazodone. |
Leuprolide Injection | Leuprolide Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Leuprolide. |
Guanabenz | Guanabenz The therapeutic efficacy of Guanabenz can be decreased when used in combination with Trazodone. |
Ketoprofen | Ketoprofen The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Ketoprofen. |
Pimozide | Pimozide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Pimozide. |
Enalapril | Enalapril Trazodone may decrease the antihypertensive activities of Enalapril. |
Flurbiprofen | Flurbiprofen The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Flurbiprofen. |
Amiodarone | Amiodarone Trazodone may increase the QTc-prolonging activities of Amiodarone. |
Buspirone | Buspirone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Buspirone. |
Lovastatin | Lovastatin The metabolism of Trazodone can be decreased when combined with Lovastatin. |
Ciprofloxacin | Ciprofloxacin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ciprofloxacin. |
Mesalamine | Mesalamine The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Mesalazine. |
Diclofenac | Diclofenac The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Diclofenac. |
Fluoxetine | Fluoxetine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Fluoxetine. |
Nimodipine | Nimodipine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Nimodipine. |
Clozapine | Clozapine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Clozapine. |
Estazolam | Estazolam The risk or severity of adverse effects can be increased when Trazodone is combined with Estazolam. |
Idarubicin | Idarubicin The metabolism of Idarubicin can be decreased when combined with Trazodone. |
Ofloxacin | Ofloxacin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ofloxacin. |
Clarithromycin | Clarithromycin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Clarithromycin. |
Benazepril | Benazepril Trazodone may decrease the antihypertensive activities of Benazepril. |
Etodolac | Etodolac The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Etodolac. |
Felodipine | Felodipine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Felodipine. |
Fosinopril | Fosinopril Trazodone may decrease the antihypertensive activities of Fosinopril. |
Nabumetone | Nabumetone The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Nabumetone. |
Quinapril | Quinapril Trazodone may decrease the antihypertensive activities of Quinapril. |
Ramipril | Ramipril Trazodone may decrease the antihypertensive activities of Ramipril. |
Simvastatin | Simvastatin The metabolism of Trazodone can be decreased when combined with Simvastatin. |
Amlodipine | Amlodipine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Amlodipine. |
Teniposide Injection | Teniposide Injection The metabolism of Trazodone can be decreased when combined with Teniposide. |
Itraconazole | Itraconazole The risk or severity of QTc prolongation can be increased when Trazodone is combined with Itraconazole. |
Lisinopril | Lisinopril Trazodone may decrease the antihypertensive activities of Lisinopril. |
Oxaprozin | Oxaprozin The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Oxaprozin. |
Sotalol | Sotalol The risk or severity of QTc prolongation can be increased when Trazodone is combined with Sotalol. |
Bisoprolol | Bisoprolol The serum concentration of Bisoprolol can be increased when it is combined with Trazodone. |
Zolpidem | Zolpidem Trazodone may increase the central nervous system depressant (CNS depressant) activities of Zolpidem. |
Doxazosin | Doxazosin Doxazosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Trazodone. |
Terazosin | Terazosin Trazodone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Terazosin. |
Isradipine | Isradipine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Isradipine. |
Omeprazole | Omeprazole The metabolism of Trazodone can be decreased when combined with Omeprazole. |
Cisapride | Cisapride The risk or severity of QTc prolongation can be increased when Trazodone is combined with Cisapride. |
Gabapentin | Gabapentin The risk or severity of adverse effects can be increased when Gabapentin is combined with Trazodone. |
Fluvastatin | Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Trazodone. |
Venlafaxine | Venlafaxine Venlafaxine may increase the serotonergic activities of Trazodone. |
Fluvoxamine | Fluvoxamine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Fluvoxamine. |
Nefazodone | Nefazodone The serum concentration of Nefazodone can be increased when it is combined with Trazodone. |
Lamotrigine | Lamotrigine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Lamotrigine. |
Losartan | Losartan The risk or severity of QTc prolongation can be increased when Trazodone is combined with Losartan. |
Tramadol | Tramadol The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Tramadol. |
Vinorelbine Injection | Vinorelbine Injection The metabolism of Trazodone can be decreased when combined with Vinorelbine. |
Moexipril | Moexipril The risk or severity of QTc prolongation can be increased when Trazodone is combined with Moexipril. |
Lansoprazole | Lansoprazole The metabolism of Trazodone can be decreased when combined with Lansoprazole. |
Ifosfamide Injection | Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Trazodone. |
Nicardipine | Nicardipine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Nicardipine. |
Bupropion | Bupropion The risk or severity of seizure can be increased when Trazodone is combined with Bupropion. |
Ticlopidine | Ticlopidine The risk or severity of bleeding can be increased when Trazodone is combined with Ticlopidine. |
Saquinavir | Saquinavir The risk or severity of QTc prolongation can be increased when Trazodone is combined with Saquinavir. |
Dalteparin Injection | Dalteparin Injection The risk or severity of bleeding can be increased when Trazodone is combined with Dalteparin. |
Nisoldipine | Nisoldipine The risk or severity of hypotension can be increased when Nisoldipine is combined with Trazodone. |
Riluzole | Riluzole The risk or severity of adverse effects can be increased when Riluzole is combined with Trazodone. |
Gemcitabine Injection | Gemcitabine Injection The serum concentration of Gemcitabine can be decreased when it is combined with Trazodone. |
Indinavir | Indinavir The metabolism of Trazodone can be decreased when combined with Indinavir. |
Ritonavir | Ritonavir The serum concentration of Ritonavir can be increased when it is combined with Trazodone. |
Docetaxel Injection | Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Trazodone. |
Clomipramine | Clomipramine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Clomipramine. |
Mirtazapine | Mirtazapine Trazodone may increase the serotonergic activities of Mirtazapine. |
Trandolapril | Trandolapril Trazodone may decrease the antihypertensive activities of Trandolapril. |
Topiramate | Topiramate The risk or severity of adverse effects can be increased when Topiramate is combined with Trazodone. |
Valsartan | Valsartan Trazodone may decrease the antihypertensive activities of Valsartan. |
Pramipexole | Pramipexole Trazodone may increase the sedative activities of Pramipexole. |
Donepezil | Donepezil The risk or severity of QTc prolongation can be increased when Trazodone is combined with Donepezil. |
Nelfinavir | Nelfinavir The risk or severity of QTc prolongation can be increased when Trazodone is combined with Nelfinavir. |
Azithromycin | Azithromycin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Azithromycin. |
Loratadine | Loratadine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Loratadine. |
Carvedilol | Carvedilol Trazodone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Carvedilol. |
Flutamide | Flutamide The metabolism of Trazodone can be decreased when combined with Flutamide. |
Selegiline | Selegiline Selegiline may increase the serotonergic activities of Trazodone. |
Bicalutamide | Bicalutamide The metabolism of Trazodone can be decreased when combined with Bicalutamide. |
Sertraline | Sertraline The risk or severity of QTc prolongation can be increased when Trazodone is combined with Sertraline. |
Propafenone | Propafenone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Propafenone. |
Irbesartan | Irbesartan Trazodone may decrease the antihypertensive activities of Irbesartan. |
Tamsulosin | Tamsulosin Trazodone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Tamsulosin. |
Ropinirole | Ropinirole Trazodone may increase the sedative activities of Ropinirole. |
Finasteride | Finasteride The metabolism of Finasteride can be decreased when combined with Trazodone. |
Quetiapine | Quetiapine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Quetiapine. |
Cetirizine | Cetirizine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Cetirizine. |
Paroxetine | Paroxetine The risk or severity of serotonin syndrome can be increased when Paroxetine is combined with Trazodone. |
Tolcapone | Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Trazodone. |
Citalopram | Citalopram The risk or severity of QTc prolongation can be increased when Trazodone is combined with Citalopram. |
Efavirenz | Efavirenz The risk or severity of QTc prolongation can be increased when Trazodone is combined with Efavirenz. |
Sildenafil | Sildenafil The metabolism of Trazodone can be decreased when combined with Sildenafil. |
Celecoxib | Celecoxib The risk or severity of bleeding can be increased when Celecoxib is combined with Trazodone. |
Rosiglitazone | Rosiglitazone The metabolism of Trazodone can be decreased when combined with Rosiglitazone. |
Tolterodine | Tolterodine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Tolterodine. |
Thalidomide | Thalidomide Trazodone may increase the central nervous system depressant (CNS depressant) activities of Thalidomide. |
Balsalazide | Balsalazide The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Balsalazide. |
Nateglinide | Nateglinide The metabolism of Nateglinide can be decreased when combined with Trazodone. |
Galantamine | Galantamine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Galantamine. |
Levetiracetam | Levetiracetam The risk or severity of adverse effects can be increased when Trazodone is combined with Levetiracetam. |
Rabeprazole | Rabeprazole The metabolism of Trazodone can be decreased when combined with Rabeprazole. |
Terbinafine | Terbinafine The metabolism of Trazodone can be decreased when combined with Terbinafine. |
Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists