Trazodone

Generic name: Pronounced as (traz' oh done)
Brand names
  • Desyrel®
  • Oleptro®
  • Trialodine®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 01/15/2022

A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as trazodone during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant. Children younger than 18 years of age should not normally take trazodone, but in some cases, a doctor may decide that trazodone is the best medication to treat a child's condition.

You should know that your mental health may change in unexpected ways when you take trazodone or other antidepressants even if you are an adult over age 24. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor when you are unable to seek treatment on your own.

Your healthcare provider will want to see you often while you are taking trazodone, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor.

The doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with trazodone. Read the information carefully and ask your doctor or pharmacist if you have any questions. You also can obtain the Medication Guide from the FDA website: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm.

No matter your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal. This risk is higher if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood) or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you.

Trazodone is used to treat depression. Trazodone is in a class of medications called serotonin modulators. It works by increasing the amount of serotonin, a natural substance in the brain that helps maintain mental balance.

Trazodone comes as a tablet to take by mouth. The tablet is usually taken with a meal or light snack two or more times a day. To help you remember to take trazodone, take it around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take trazodone exactly as directed. Do not take more or less of it, take it more often, or take it for a longer time than prescribed by your doctor.

Swallow the tablets whole or broken in half on the score mark.

Your doctor may start you on a low dose of trazodone and gradually increase your dose, not more than once every 3 to 4 days. Your doctor may decrease your dose once your condition is controlled.

Trazodone controls depression, but does not cure it. It may take 2 weeks or longer before you feel the full benefit of trazodone. Continue to take trazodone even if you feel well.

Do not stop taking trazodone without talking to your doctor. If you suddenly stop taking trazodone, you may experience withdrawal symptoms such as dizziness; nausea; headache; confusion; anxiety; agitation; difficulty falling asleep or staying asleep; extreme tiredness; seizures; pain, burning, or tingling in the hands or feet; frenzied or abnormally excited mood; ringing in the ears; or sweating. Your doctor will probably decrease your dose gradually.

Trazodone is also sometimes used to treat insomnia and schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions); anxiety (excessive worry). Trazodone is also sometimes used to control abnormal, uncontrollable movements that may be experienced as side effects of other medications and for the management of alcohol dependence. Talk to your doctor about the possible risks of using this medication for your condition.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Before taking trazodone,

  • tell your doctor and pharmacist if you are allergic to trazodone or any other medications.

  • tell your doctor if you are taking a monoamine oxidase (MAO) inhibitor, such as isocarboxazid (Marplan), linezolid, methylene blue, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), or if you have stopped taking one of these medications within the past 14 days. Your doctor will probably tell you that you should not take trazodone. If you stop taking trazodone, your doctor will tell you that you should wait at least 14 days before you start to take an MAO inhibitor.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: amiodarone (Nexterone, Pacerone); anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); antifungals such as itraconazole (Sporanox, Tolsura), ketoconazole, or voriconazole (Vfend); aspirin and other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); buspirone; carbamazepine (Carbatrol, Equetro, Tegretol, others); chlorpromazine; clarithromycin (Biaxin); clopidogrel (Plavix); dabigatran (Pradaxa); digoxin (Lanoxin); disopyramide (Norpace); diuretics ('water pills'); fentanyl (Actiq, Duragesic, Fentora, Subsys); indinavir (Crixivan); lithium (Lithobid); medications for anxiety, irregular heartbeat, mental illness or pain; medications for migraine headaches such as almotriptan, eletriptan (Relpax), frovatriptan (Frova), naratriptan, rizatriptan (Maxalt), and sumatriptan (Imitrex); phenobarbital; phenytoin (Dilantin, Phenytek); procainamide; quinidine (in Nuedexta); rifampin (Rifadin, Rimactane); rivaroxaban (Xarelto);sedatives; selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac), fluvoxamine (Luvox), paroxetine (Paxil, Pexeva), and sertraline (Zoloft); tranquilizers; sotalol (Betapace, Sorine, Sotylize); thioridazine; tramadol (Conzip, Qdola, Ultram, in Ultracet); tricyclic antidepressants such as amitriptyline, amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline, and trimipramine; or ziprasidone (Geodon). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with trazodone, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor what herbal products and nutritional supplements you are taking, especially St. John's wort and tryptophan.

  • tell your doctor if you or anyone in your family has or has ever had long QT syndrome (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death), if you have ever had a heart attack, or if you have a low level of sodium in your blood. Also tell your doctor if you drink or have ever drunk large amounts of alcohol, or if you have or have ever had high blood pressure; bleeding problems; sickle cell anemia (a disease of the red blood cells); multiple myeloma (cancer of the plasma cells); leukemia (cancer of the white blood cells); cavernosal fibrosis or Peyronie's disease (conditions that affects the shape of the penis such as angulation); or heart, liver, or kidney disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking trazodone, call your doctor.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking trazodone.

  • you should know that trazodone may make you drowsy and affect your judgment, thinking, and movements. Do not drive a car or operate machinery until you know how this medication affects you.

  • ask your doctor about the safe use of alcoholic beverages while you are taking trazodone. Alcohol can make the side effects from trazodone worse.

  • you should know that trazodone may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

  • you should know that trazodone may cause angle-closure glaucoma (a condition where the fluid is suddenly blocked and unable to flow out of the eye causing a quick, severe increase in eye pressure which may lead to a loss of vision). Talk to your doctor about having an eye examination before you start taking this medication. If you have nausea, eye pain, changes in vision, such as seeing colored rings around lights, and swelling or redness in or around the eye, call your doctor or get emergency medical treatment right away.

Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Trazodone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • vomiting

    • diarrhea

    • constipation

    • changes in appetite or weight

    • weakness or tiredness

    • nervousness

    • dizziness or lightheadedness

    • nightmares

    • muscle pain

    • dry mouth

    • rash

    • sexual problems in males; decreased sex drive, inability to get or keep an erection, or delayed or absent ejaculation

    • sexual problems in females; decreased sex drive, or delayed orgasm or unable to have an orgasm

    • uncontrollable shaking of a part of the body

    • stuffy nose

    • tired, red, or itchy eyes

  • Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS sections, call your doctor immediately or get emergency medical treatment:

    • chest pain

    • fast, pounding, or irregular heartbeat

    • loss of consciousness (coma)

    • fever, sweating, confusion, fast or irregular heartbeat, and severe muscle stiffness or twitching, agitation, hallucinations, loss of coordination, nausea, vomiting, or diarrhea

    • fainting

    • seizures

    • shortness of breath

    • unusual bruising or bleeding

    • nosebleeds

    • small red or purple dots on the skin

    • erection lasting more than 6 hours

    • headache

    • problems with thinking, concentration, or memory

    • weakness

    • problems with coordination

  • Trazodone can cause painful, long lasting erections in males. In some cases emergency and/or surgical treatment has been required and, in some of these cases, permanent damage has occurred. Talk to your doctor about the risk of taking trazodone.

  • Trazodone may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat, and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

  • vomiting

  • drowsiness

  • changes in heartbeat

  • seizures

  • difficulty breathing

  • painful erection that does not go away

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Moxifloxacin.
Delavirdine Delavirdine The serum concentration of Trazodone can be increased when it is combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Trazodone can be decreased when combined with Nevirapine.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Trazodone.
Dolasetron Dolasetron The risk or severity of QTc prolongation can be increased when Trazodone is combined with Dolasetron.
Anagrelide Anagrelide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Anagrelide.
Candesartan Candesartan Trazodone may decrease the antihypertensive activities of Candesartan.
Cilostazol Cilostazol The risk or severity of QTc prolongation can be increased when Trazodone is combined with Cilostazol.
Clopidogrel Clopidogrel The risk or severity of bleeding can be increased when Trazodone is combined with Clopidogrel.
Diphenoxylate Diphenoxylate The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Diphenoxylate.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The risk or severity of QTc prolongation can be increased when Trazodone is combined with Erythromycin.
Guanfacine Guanfacine The risk or severity of adverse effects can be increased when Guanfacine is combined with Trazodone.
Methylergonovine Methylergonovine The risk or severity of hypertension can be increased when Methylergometrine is combined with Trazodone.
Naratriptan Naratriptan The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Naratriptan.
Olsalazine Olsalazine The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Olsalazine.
Paregoric Paregoric The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Morphine.
Penbutolol Penbutolol The risk or severity of QTc prolongation can be increased when Trazodone is combined with Acebutolol.
Pentazocine Pentazocine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Pentazocine.
Ranitidine Ranitidine The metabolism of Trazodone can be decreased when combined with Ranitidine.
Reserpine Reserpine The risk or severity of adverse effects can be increased when Reserpine is combined with Trazodone.
Rizatriptan Rizatriptan The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Rizatriptan.
Sumatriptan Sumatriptan The risk or severity of adverse effects can be increased when Sumatriptan is combined with Trazodone.
Tacrolimus Tacrolimus The risk or severity of QTc prolongation can be increased when Trazodone is combined with Tacrolimus.
Tizanidine Tizanidine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Tizanidine.
Triamcinolone Triamcinolone The metabolism of Trazodone can be increased when combined with Triamcinolone.
Zolmitriptan Zolmitriptan The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Zolmitriptan.
Famotidine Injection Famotidine Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Famotidine.
Fluconazole Injection Fluconazole Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Fluconazole.
Foscarnet Injection Foscarnet Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Foscarnet.
Hydromorphone Injection Hydromorphone Injection The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Hydromorphone.
Levofloxacin Injection Levofloxacin Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Levofloxacin.
Meperidine Injection Meperidine Injection The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Meperidine.
Metoclopramide Injection Metoclopramide Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Metoclopramide.
Metronidazole Injection Metronidazole Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Metronidazole.
Morphine Injection Morphine Injection The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Morphine.
Altretamine Altretamine Amphetamine may increase the serotonergic activities of Trazodone.
Cyclosporine Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Trazodone.
Ondansetron Ondansetron The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ondansetron.
Enoxaparin Injection Enoxaparin Injection The risk or severity of bleeding can be increased when Trazodone is combined with Enoxaparin.
Granisetron Granisetron The risk or severity of QTc prolongation can be increased when Trazodone is combined with Granisetron.
Torsemide Torsemide Trazodone may decrease the antihypertensive activities of Torasemide.
Olanzapine Olanzapine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Olanzapine.
Alosetron Alosetron The risk or severity of adverse effects can be increased when Alosetron is combined with Trazodone.
Dofetilide Dofetilide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Dofetilide.
Entacapone Entacapone The risk or severity of adverse effects can be increased when Entacapone is combined with Trazodone.
Eprosartan Eprosartan Trazodone may decrease the antihypertensive activities of Eprosartan.
Hydroxychloroquine Hydroxychloroquine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Hydroxychloroquine.
Meloxicam Meloxicam The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Meloxicam.
Oxcarbazepine Oxcarbazepine The risk or severity of adverse effects can be increased when Oxcarbazepine is combined with Trazodone.
Telmisartan Telmisartan Trazodone may decrease the antihypertensive activities of Telmisartan.
Zaleplon Zaleplon The risk or severity of adverse effects can be increased when Zaleplon is combined with Trazodone.
Anakinra Anakinra The metabolism of Trazodone can be increased when combined with Anakinra.
Desloratadine Desloratadine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Desloratadine.
Linezolid Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Trazodone.
Pentosan Polysulfate Pentosan Polysulfate The risk or severity of bleeding can be increased when Trazodone is combined with Pentosan polysulfate.
Trimipramine Trimipramine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Trimipramine.
Etanercept Injection Etanercept Injection The metabolism of Trazodone can be increased when combined with Etanercept.
Glycopyrrolate Glycopyrrolate Trazodone may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
Modafinil Modafinil The metabolism of Trazodone can be increased when combined with Modafinil.
Perindopril Perindopril Trazodone may decrease the antihypertensive activities of Perindopril.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Choline magnesium trisalicylate.
Sirolimus Sirolimus The metabolism of Sirolimus can be decreased when combined with Trazodone.
Dutasteride Dutasteride The metabolism of Dutasteride can be decreased when combined with Trazodone.
Epinephrine Injection Epinephrine Injection The therapeutic efficacy of Epinephrine can be decreased when used in combination with Trazodone.
Eplerenone Eplerenone The metabolism of Eplerenone can be decreased when combined with Trazodone.
Escitalopram Escitalopram The risk or severity of QTc prolongation can be increased when Trazodone is combined with Escitalopram.
Olmesartan Olmesartan Trazodone may decrease the antihypertensive activities of Olmesartan.
Zonisamide Zonisamide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Zonisamide.
Adalimumab Injection Adalimumab Injection The metabolism of Trazodone can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The risk or severity of QTc prolongation can be increased when Trazodone is combined with Aripiprazole.
Atomoxetine Atomoxetine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Atomoxetine.
Dexmethylphenidate Dexmethylphenidate The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Dexmethylphenidate.
Teriparatide Injection Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Trazodone.
Atazanavir Atazanavir The risk or severity of QTc prolongation can be increased when Trazodone is combined with Atazanavir.
Almotriptan Almotriptan The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Almotriptan.
Eletriptan Eletriptan The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Eletriptan.
Mefloquine Mefloquine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Mefloquine.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Trazodone.
Vardenafil Vardenafil The risk or severity of QTc prolongation can be increased when Trazodone is combined with Vardenafil.
Alfuzosin Alfuzosin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Alfuzosin.
Aprepitant Aprepitant The metabolism of Trazodone can be decreased when combined with Aprepitant.
Tegaserod Tegaserod The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Tegaserod.
Tadalafil Tadalafil The risk or severity of hypotension, dyspepsia, and headache can be increased when Trazodone is combined with Tadalafil.
Frovatriptan Frovatriptan The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Frovatriptan.
Gemifloxacin Gemifloxacin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Gemifloxacin.
Progesterone Progesterone The metabolism of Trazodone can be decreased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Apomorphine.
Infliximab Injection Infliximab Injection The metabolism of Trazodone can be increased when combined with Infliximab.
Protriptyline Protriptyline The risk or severity of QTc prolongation can be increased when Trazodone is combined with Protriptyline.
Rifaximin Rifaximin The serum concentration of Trazodone can be decreased when it is combined with Rifaximin.
Duloxetine Duloxetine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Norethisterone can be decreased when combined with Trazodone.
Trospium Trospium Trazodone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Bosentan Bosentan Trazodone may decrease the antihypertensive activities of Bosentan.
Cinacalcet Cinacalcet The metabolism of Trazodone can be decreased when combined with Cinacalcet.
Erlotinib Erlotinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Erlotinib.
Eszopiclone Eszopiclone The risk or severity of CNS depression can be increased when Trazodone is combined with Eszopiclone.
Solifenacin Solifenacin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Solifenacin.
Voriconazole Voriconazole The risk or severity of QTc prolongation can be increased when Trazodone is combined with Voriconazole.
Dextroamphetamine Dextroamphetamine Amphetamine may increase the serotonergic activities of Trazodone.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The metabolism of Trazodone can be decreased when combined with Peginterferon alfa-2b.
Sodium Oxybate Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Trazodone.
Ibandronate Ibandronate The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ibandronate.
Isocarboxazid Isocarboxazid Isocarboxazid may increase the serotonergic activities of Trazodone.
Ramelteon Ramelteon The risk or severity of adverse effects can be increased when Ramelteon is combined with Trazodone.
Darifenacin Darifenacin The metabolism of Darifenacin can be decreased when combined with Trazodone.
Fentanyl Fentanyl The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Fentanyl.
Pregabalin Pregabalin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Pregabalin.
Phenylephrine Phenylephrine The therapeutic efficacy of Phenylephrine can be decreased when used in combination with Trazodone.
Tipranavir Tipranavir The serum concentration of Tipranavir can be increased when it is combined with Trazodone.
Felbamate Felbamate The risk or severity of QTc prolongation can be increased when Trazodone is combined with Felbamate.
Ranolazine Ranolazine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Trazodone can be increased when combined with Abatacept.
Rasagiline Rasagiline Rasagiline may increase the serotonergic activities of Trazodone.
Imatinib Imatinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Imatinib.
Gefitinib Gefitinib The metabolism of Trazodone can be decreased when combined with Gefitinib.
Albuterol Albuterol The risk or severity of QTc prolongation can be increased when Trazodone is combined with Salbutamol.
Paliperidone Paliperidone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Paliperidone.
Bortezomib Bortezomib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Bortezomib.
Oxaliplatin Injection Oxaliplatin Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Oxaliplatin.
Posaconazole Posaconazole The risk or severity of QTc prolongation can be increased when Trazodone is combined with Posaconazole.
Primaquine Primaquine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Primaquine.
Aliskiren Aliskiren Trazodone may decrease the antihypertensive activities of Aliskiren.
Darunavir Darunavir The serum concentration of Trazodone can be increased when it is combined with Darunavir.
Dimenhydrinate Dimenhydrinate The risk or severity of QTc prolongation can be increased when Trazodone is combined with Dimenhydrinate.
Lisdexamfetamine Lisdexamfetamine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Lisdexamfetamine.
Nabilone Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Trazodone.
Vorinostat Vorinostat The risk or severity of QTc prolongation can be increased when Trazodone is combined with Vorinostat.
Sorafenib Sorafenib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Sorafenib.
Sunitinib Sunitinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Sunitinib.
Dronabinol Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Trazodone.
Lapatinib Lapatinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Lapatinib.
Levocetirizine Levocetirizine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Levocetirizine.
Dasatinib Dasatinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Dasatinib.
Mexiletine Mexiletine The metabolism of Mexiletine can be decreased when combined with Trazodone.
Armodafinil Armodafinil The metabolism of Trazodone can be increased when combined with Armodafinil.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Trazodone.
Nilotinib Nilotinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Nilotinib.
Toremifene Toremifene The risk or severity of QTc prolongation can be increased when Trazodone is combined with Toremifene.
Budesonide Budesonide The metabolism of Trazodone can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Trazodone can be decreased when combined with Chloramphenicol.
Desmopressin Desmopressin The risk or severity of hyponatremia can be increased when Trazodone is combined with Desmopressin.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Trazodone.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Botulinum Toxin Type B is combined with Trazodone.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Arsenic trioxide.
Desvenlafaxine Desvenlafaxine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Desvenlafaxine.
Cevimeline Cevimeline The metabolism of Cevimeline can be decreased when combined with Trazodone.
Nebivolol Nebivolol The serum concentration of Nebivolol can be increased when it is combined with Trazodone.
Tretinoin Tretinoin The metabolism of Tretinoin can be decreased when combined with Trazodone.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be decreased when it is combined with Trazodone.
Flecainide Flecainide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Flecainide.
Certolizumab Injection Certolizumab Injection The metabolism of Trazodone can be increased when combined with Certolizumab pegol.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Trazodone.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Trazodone.
Mitotane Mitotane The serum concentration of Trazodone can be decreased when it is combined with Mitotane.
Rufinamide Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Trazodone.
Silodosin Silodosin Trazodone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Silodosin.
Midazolam Midazolam The risk or severity of adverse effects can be increased when Trazodone is combined with Midazolam.
Naltrexone Injection Naltrexone Injection The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Naltrexone.
Milnacipran Milnacipran The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Milnacipran.
Fesoterodine Fesoterodine Trazodone may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine.
Degarelix Injection Degarelix Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Degarelix.
Betaxolol Betaxolol The risk or severity of QTc prolongation can be increased when Trazodone is combined with Betaxolol.
Iloperidone Iloperidone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Iloperidone.
Prasugrel Prasugrel The risk or severity of bleeding can be increased when Trazodone is combined with Prasugrel.
Lacosamide Lacosamide The risk or severity of adverse effects can be increased when Lacosamide is combined with Trazodone.
Everolimus Everolimus The serum concentration of Trazodone can be decreased when it is combined with Everolimus.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be decreased when it is combined with Trazodone.
Dronedarone Dronedarone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Dronedarone.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Trazodone.
Palonosetron Injection Palonosetron Injection The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Palonosetron.
Saxagliptin Saxagliptin The metabolism of Saxagliptin can be decreased when combined with Trazodone.
Telavancin Injection Telavancin Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Telavancin.
Romidepsin Injection Romidepsin Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Romidepsin.
Tapentadol Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Trazodone.
Topotecan Topotecan The serum concentration of Topotecan can be decreased when it is combined with Trazodone.
Golimumab Injection Golimumab Injection The metabolism of Trazodone can be increased when combined with Golimumab.
Pazopanib Pazopanib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Pazopanib.
Asenapine Asenapine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Asenapine.
Vigabatrin Vigabatrin The risk or severity of adverse effects can be increased when Vigabatrin is combined with Trazodone.
Levonorgestrel Levonorgestrel The metabolism of Trazodone can be decreased when combined with Levonorgestrel.
Oxymorphone Oxymorphone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Oxymorphone.
Dabigatran Dabigatran The risk or severity of bleeding can be increased when Trazodone is combined with Dabigatran.
Tocilizumab Injection Tocilizumab Injection The metabolism of Trazodone can be increased when combined with Tocilizumab.
Dalfampridine Dalfampridine The risk or severity of seizure can be increased when Trazodone is combined with Dalfampridine.
Fingolimod Fingolimod The risk or severity of QTc prolongation can be increased when Trazodone is combined with Fingolimod.
Eribulin Injection Eribulin Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Eribulin.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Trazodone.
Cabazitaxel Injection Cabazitaxel Injection The serum concentration of Cabazitaxel can be decreased when it is combined with Trazodone.
Lurasidone Lurasidone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Lurasidone.
Acetaminophen Injection Acetaminophen Injection The metabolism of Acetaminophen can be decreased when combined with Trazodone.
Vilazodone Vilazodone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Vilazodone.
Terbutaline Injection Terbutaline Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Terbutaline.
Linagliptin Linagliptin The serum concentration of Linagliptin can be decreased when it is combined with Trazodone.
Rilpivirine Rilpivirine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Rilpivirine.
Potassium Iodide Potassium Iodide The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Trazodone.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Trazodone can be decreased when combined with Cyclophosphamide.
Abiraterone Abiraterone The metabolism of Trazodone can be decreased when combined with Abiraterone.
Triptorelin Injection Triptorelin Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Triptorelin.
Rivaroxaban Rivaroxaban The risk or severity of bleeding can be increased when Trazodone is combined with Rivaroxaban.
Ticagrelor Ticagrelor The risk or severity of bleeding can be increased when Trazodone is combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be decreased when it is combined with Trazodone.
Vandetanib Vandetanib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Vandetanib.
Clobazam Clobazam The metabolism of Trazodone can be decreased when combined with Clobazam.
Vemurafenib Vemurafenib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Vemurafenib.
Ivacaftor Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Trazodone.
Axitinib Axitinib The serum concentration of Axitinib can be decreased when it is combined with Trazodone.
Crizotinib Crizotinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Crizotinib.
Cabergoline Cabergoline The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Cabergoline.
Naloxone Injection Naloxone Injection The serum concentration of Trazodone can be increased when it is combined with Naloxone.
Ambrisentan Ambrisentan The metabolism of Ambrisentan can be decreased when combined with Trazodone.
Fondaparinux Injection Fondaparinux Injection The risk or severity of bleeding can be increased when Trazodone is combined with Fondaparinux.
Ezogabine Ezogabine The risk or severity of adverse effects can be increased when Tiagabine is combined with Trazodone.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Carfilzomib can be decreased when it is combined with Trazodone.
Iloprost Iloprost The risk or severity of bleeding can be increased when Trazodone is combined with Iloprost.
Enzalutamide Enzalutamide The serum concentration of Trazodone can be decreased when it is combined with Enzalutamide.
Mirabegron Mirabegron The risk or severity of QTc prolongation can be increased when Trazodone is combined with Mirabegron.
Regorafenib Regorafenib The serum concentration of Regorafenib can be decreased when it is combined with Trazodone.
Bosutinib Bosutinib The serum concentration of Bosutinib can be decreased when it is combined with Trazodone.
Bedaquiline Bedaquiline The risk or severity of QTc prolongation can be increased when Trazodone is combined with Bedaquiline.
Icosapent Ethyl Icosapent Ethyl The risk or severity of bleeding can be increased when Trazodone is combined with Icosapent ethyl.
Alogliptin Alogliptin The metabolism of Alogliptin can be decreased when combined with Trazodone.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Trazodone.
Pomalidomide Pomalidomide The serum concentration of Trazodone can be decreased when it is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The serum concentration of Trastuzumab emtansine can be decreased when it is combined with Trazodone.
Apixaban Apixaban The risk or severity of bleeding can be increased when Trazodone is combined with Apixaban.
Dabrafenib Dabrafenib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Trazodone can be decreased when combined with Ospemifene.
Afatinib Afatinib The serum concentration of Afatinib can be decreased when it is combined with Trazodone.
Levomilnacipran Levomilnacipran The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Levomilnacipran.
Vortioxetine Vortioxetine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Vortioxetine.
Perampanel Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Trazodone.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Trazodone.
Avanafil Avanafil The risk or severity of hypotension, dyspepsia, and headache can be increased when Avanafil is combined with Trazodone.
Ketorolac Injection Ketorolac Injection The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Ketorolac.
Sofosbuvir Sofosbuvir The serum concentration of Sofosbuvir can be decreased when it is combined with Trazodone.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Trazodone.
Apremilast Apremilast The metabolism of Trazodone can be increased when combined with Apremilast.
Droxidopa Droxidopa The therapeutic efficacy of Droxidopa can be decreased when used in combination with Trazodone.
Ceritinib Ceritinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Trazodone can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The risk or severity of adverse effects can be increased when Eslicarbazepine is combined with Trazodone.
Testosterone Injection Testosterone Injection The metabolism of Trazodone can be decreased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Trazodone can be decreased when combined with Oritavancin.
Vorapaxar Vorapaxar The risk or severity of bleeding can be increased when Trazodone is combined with Vorapaxar.
Hydrocodone Hydrocodone Hydrocodone may increase the central nervous system depressant (CNS depressant) activities of Trazodone.
Suvorexant Suvorexant Trazodone may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Edoxaban Edoxaban The risk or severity of bleeding can be increased when Trazodone is combined with Edoxaban.
Olaparib Olaparib The metabolism of Olaparib can be decreased when combined with Trazodone.
Methamphetamine Methamphetamine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Metamfetamine.
Tasimelteon Tasimelteon The risk or severity of adverse effects can be increased when Tasimelteon is combined with Trazodone.
Riociguat Riociguat Trazodone may decrease the antihypertensive activities of Riociguat.
Secukinumab Injection Secukinumab Injection The metabolism of Trazodone can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Risperidone.
Lenvatinib Lenvatinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Lenvatinib.
Naloxegol Naloxegol The metabolism of Trazodone can be decreased when combined with Naloxegol.
Panobinostat Panobinostat The risk or severity of QTc prolongation can be increased when Trazodone is combined with Panobinostat.
Haloperidol Injection Haloperidol Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Haloperidol.
Ivabradine Ivabradine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ivabradine.
Macitentan Macitentan Trazodone may decrease the antihypertensive activities of Macitentan.
Flibanserin Flibanserin The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Flibanserin.
Rolapitant Rolapitant The metabolism of Trazodone can be decreased when combined with Rolapitant.
Daclatasvir Daclatasvir The metabolism of Daclatasvir can be decreased when combined with Trazodone.
Brexpiprazole Brexpiprazole The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ziprasidone.
Cariprazine Cariprazine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Cariprazine.
Eluxadoline Eluxadoline The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Eluxadoline.
Cobimetinib Cobimetinib The serum concentration of Cobimetinib can be decreased when it is combined with Trazodone.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Trazodone.
Osimertinib Osimertinib The serum concentration of Osimertinib can be decreased when it is combined with Trazodone.
Dexamethasone Injection Dexamethasone Injection The serum concentration of Trazodone can be decreased when it is combined with Dexamethasone.
Defibrotide Injection Defibrotide Injection The risk or severity of bleeding can be increased when Trazodone is combined with Defibrotide.
Brivaracetam Injection Brivaracetam Injection The risk or severity of adverse effects can be increased when Brivaracetam is combined with Trazodone.
Venetoclax Venetoclax The serum concentration of Venetoclax can be decreased when it is combined with Trazodone.
Cobicistat Cobicistat The serum concentration of Trazodone can be increased when it is combined with Cobicistat.
Midodrine Midodrine The therapeutic efficacy of Midodrine can be decreased when used in combination with Trazodone.
Selexipag Selexipag Trazodone may decrease the antihypertensive activities of Selexipag.
Pimavanserin Pimavanserin The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Pimavanserin.
Diphenhydramine Injection Diphenhydramine Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Diphenhydramine.
Furosemide Injection Furosemide Injection Trazodone may decrease the antihypertensive activities of Furosemide.
Rucaparib Rucaparib The metabolism of Trazodone can be decreased when combined with Rucaparib.
Ribociclib Ribociclib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ribociclib.
Parathyroid Hormone Injection Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Trazodone.
Doxepin (Insomnia) Doxepin (Insomnia) The risk or severity of QTc prolongation can be increased when Trazodone is combined with Doxepin.
Deutetrabenazine Deutetrabenazine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Deutetrabenazine.
Valbenazine Valbenazine The metabolism of Valbenazine can be decreased when combined with Trazodone.
Deflazacort Deflazacort The metabolism of Trazodone can be increased when combined with Deflazacort.
Safinamide Safinamide Safinamide may increase the serotonergic activities of Trazodone.
Midostaurin Midostaurin The serum concentration of Trazodone can be increased when it is combined with Midostaurin.
Abaloparatide Injection Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Trazodone.
Enasidenib Enasidenib The metabolism of Enasidenib can be decreased when combined with Trazodone.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be decreased when it is combined with Trazodone.
Copanlisib Injection Copanlisib Injection The serum concentration of Copanlisib can be decreased when it is combined with Trazodone.
Delafloxacin Delafloxacin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Delafloxacin.
Abemaciclib Abemaciclib The serum concentration of Abemaciclib can be decreased when it is combined with Trazodone.
Betrixaban Betrixaban The risk or severity of bleeding can be increased when Trazodone is combined with Betrixaban.
Acalabrutinib Acalabrutinib The metabolism of Trazodone can be decreased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Trazodone can be decreased when combined with Letermovir.
Tetrabenazine Tetrabenazine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Tetrabenazine.
Buprenorphine Injection Buprenorphine Injection Trazodone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Apalutamide Apalutamide The serum concentration of Trazodone can be decreased when it is combined with Apalutamide.
Fostamatinib Fostamatinib The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Trazodone.
Lofexidine Lofexidine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Lofexidine.
Eliglustat Eliglustat The risk or severity of QTc prolongation can be increased when Trazodone is combined with Eliglustat.
Encorafenib Encorafenib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Encorafenib.
Binimetinib Binimetinib The serum concentration of Binimetinib can be decreased when it is combined with Trazodone.
Ivosidenib Ivosidenib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ivosidenib.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Trazodone.
Doravirine Doravirine The metabolism of Doravirine can be decreased when combined with Trazodone.
Tafenoquine Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Trazodone.
Cannabidiol Cannabidiol The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Cannabidiol.
Dacomitinib Dacomitinib The serum concentration of Trazodone can be decreased when it is combined with Dacomitinib.
Stiripentol Stiripentol The serum concentration of Trazodone can be increased when it is combined with Stiripentol.
Talazoparib Talazoparib The serum concentration of Talazoparib can be decreased when it is combined with Trazodone.
Gilteritinib Gilteritinib The therapeutic efficacy of Trazodone can be decreased when used in combination with Gilteritinib.
Glasdegib Glasdegib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Glasdegib.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Trazodone.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Trazodone.
Rifamycin Rifamycin The serum concentration of Trazodone can be decreased when it is combined with Rifamycin.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Trazodone can be increased when combined with Emapalumab.
Siponimod Siponimod The risk or severity of hypertension can be increased when Trazodone is combined with Siponimod.
Caplacizumab-yhdp Injection Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Trazodone is combined with Caplacizumab.
Brexanolone Injection Brexanolone Injection The risk or severity of adverse effects can be increased when Brexanolone is combined with Trazodone.
Solriamfetol Solriamfetol The risk or severity of hypertension can be increased when Solriamfetol is combined with Trazodone.
Triclabendazole Triclabendazole The risk or severity of QTc prolongation can be increased when Trazodone is combined with Triclabendazole.
Entrectinib Entrectinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Entrectinib.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Trazodone.
Pitolisant Pitolisant The therapeutic efficacy of Pitolisant can be decreased when used in combination with Trazodone.
Fedratinib Fedratinib The metabolism of Trazodone can be decreased when combined with Fedratinib.
Lefamulin Lefamulin Trazodone may increase the QTc-prolonging activities of Lefamulin.
Phenytoin Injection Phenytoin Injection The serum concentration of Phenytoin can be increased when it is combined with Trazodone.
Fosphenytoin Injection Fosphenytoin Injection The serum concentration of Fosphenytoin can be increased when it is combined with Trazodone.
Lumateperone Lumateperone The risk or severity of adverse effects can be increased when Lumateperone is combined with Trazodone.
Lasmiditan Lasmiditan The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Lasmiditan.
Cenobamate Cenobamate The serum concentration of Trazodone can be decreased when it is combined with Cenobamate.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Trazodone.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Trazodone.
Selpercatinib Selpercatinib The risk or severity of QTc prolongation can be increased when Trazodone is combined with Selpercatinib.
Lemborexant Lemborexant The risk or severity of adverse effects can be increased when Trazodone is combined with Lemborexant.
Daratumumab and Hyaluronidase-fihj Injection Daratumumab and Hyaluronidase-fihj Injection The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Trazodone.
Fenfluramine Fenfluramine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Fenfluramine.
Fostemsavir Fostemsavir The risk or severity of QTc prolongation can be increased when Trazodone is combined with Fostemsavir.
Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf Injection Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf Injection The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Trazodone.
Octreotide Octreotide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Octreotide.
Pralsetinib Pralsetinib The metabolism of Trazodone can be decreased when combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Trazodone can be decreased when it is combined with Satralizumab.
Naxitamab-gqgk Injection Naxitamab-gqgk Injection The risk or severity of hypertension can be increased when Trazodone is combined with Naxitamab.
Relugolix Relugolix The serum concentration of Relugolix can be decreased when it is combined with Trazodone.
Viloxazine Viloxazine The risk or severity of adverse effects can be increased when Trazodone is combined with Viloxazine.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Trazodone.
Fenoprofen Fenoprofen The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Fenoprofen.
Indomethacin Indomethacin The risk or severity of gastrointestinal bleeding can be increased when Indomethacin is combined with Trazodone.
Mefenamic Acid Mefenamic Acid The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Mefenamic acid.
Naproxen Naproxen The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Naproxen.
Tolmetin Tolmetin The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Tolmetin.
Sulindac Sulindac The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Sulindac.
Hydroxyurea Hydroxyurea The metabolism of Trazodone can be decreased when combined with Hydroxyurea.
Phenobarbital Phenobarbital The serum concentration of Trazodone can be decreased when it is combined with Phenobarbital.
Metaxalone Metaxalone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Metaxalone.
Levorphanol Levorphanol The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Levorphanol.
Primidone Primidone The serum concentration of Trazodone can be decreased when it is combined with Primidone.
Methsuximide Methsuximide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Methsuximide.
Diethylpropion Diethylpropion The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Diethylpropion.
Chlorpromazine Chlorpromazine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Chlorpromazine.
Diazepam Diazepam The risk or severity of adverse effects can be increased when Trazodone is combined with Diazepam.
Oxazepam Oxazepam The risk or severity of adverse effects can be increased when Trazodone is combined with Oxazepam.
Flurazepam Flurazepam The risk or severity of adverse effects can be increased when Trazodone is combined with Flurazepam.
Clorazepate Clorazepate The risk or severity of adverse effects can be increased when Clorazepic acid is combined with Trazodone.
Lorazepam Lorazepam The risk or severity of adverse effects can be increased when Lorazepam is combined with Trazodone.
Phenoxybenzamine Phenoxybenzamine Trazodone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Phenoxybenzamine.
Amantadine Amantadine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Amantadine.
Codeine Codeine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Codeine.
Meprobamate Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Trazodone.
Chlordiazepoxide Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Trazodone.
Bromocriptine Bromocriptine Trazodone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Bromocriptine.
Metaproterenol Metaproterenol The therapeutic efficacy of Orciprenaline can be decreased when used in combination with Trazodone.
Tranylcypromine Tranylcypromine Tranylcypromine may increase the serotonergic activities of Trazodone.
Phenelzine Phenelzine Phenelzine may increase the serotonergic activities of Trazodone.
Procarbazine Procarbazine Procarbazine may increase the serotonergic activities of Trazodone.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Ergoloid mesylate.
Minocycline Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Trazodone.
Prochlorperazine Prochlorperazine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Prochlorperazine.
Thioridazine Thioridazine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Thioridazine.
Trifluoperazine Trifluoperazine Trazodone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Trifluoperazine.
Dapsone Dapsone The metabolism of Trazodone can be decreased when combined with Dapsone.
Oxycodone Oxycodone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Oxycodone.
Methadone Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Trazodone.
Oxybutynin Oxybutynin The metabolism of Oxybutynin can be decreased when combined with Trazodone.
Benztropine Benztropine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Benzatropine.
Maprotiline Maprotiline The risk or severity of QTc prolongation can be increased when Trazodone is combined with Maprotiline.
Ibuprofen Ibuprofen The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Ibuprofen.
Trihexyphenidyl Trihexyphenidyl Trazodone may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine Orphenadrine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Orphenadrine.
Perphenazine Perphenazine The risk or severity of adverse effects can be increased when Trazodone is combined with Perphenazine.
Fluphenazine Fluphenazine The risk or severity of adverse effects can be increased when Fluphenazine is combined with Trazodone.
Phentermine Phentermine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Phentermine.
Methylphenidate Methylphenidate The risk or severity of hypertension can be increased when Methylphenidate is combined with Trazodone.
Amoxapine Amoxapine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Amoxapine.
Sulfasalazine Sulfasalazine The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Sulfasalazine.
Hydrocortisone Hydrocortisone The metabolism of Hydrocortisone can be decreased when combined with Trazodone.
Doxorubicin Doxorubicin The serum concentration of Doxorubicin can be decreased when it is combined with Trazodone.
Dactinomycin Dactinomycin The serum concentration of Dactinomycin can be decreased when it is combined with Trazodone.
Carbamazepine Carbamazepine The serum concentration of Trazodone can be decreased when it is combined with Carbamazepine.
Molindone Molindone The risk or severity of adverse effects can be increased when Trazodone is combined with Molindone.
Methyldopa Methyldopa The therapeutic efficacy of Methyldopa can be decreased when used in combination with Trazodone.
Clonidine Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Trazodone.
Prazosin Prazosin Prazosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Trazodone.
Hydralazine Hydralazine Trazodone may decrease the antihypertensive activities of Hydralazine.
Cimetidine Cimetidine The metabolism of Trazodone can be decreased when combined with Cimetidine.
Warfarin Warfarin Trazodone may decrease the anticoagulant activities of Warfarin.
Clonazepam Clonazepam The risk or severity of adverse effects can be increased when Clonazepam is combined with Trazodone.
Loperamide Loperamide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Loperamide.
Promethazine Promethazine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Promethazine.
Meclofenamate Meclofenamate The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Meclofenamic acid.
Daunorubicin Daunorubicin The metabolism of Trazodone can be increased when combined with Daunorubicin.
Digoxin Digoxin The serum concentration of Digoxin can be increased when it is combined with Trazodone.
Loxapine Loxapine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Loxapine.
Chloroquine Chloroquine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Chloroquine.
Quinine Quinine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Quinine.
Ethosuximide Ethosuximide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ethosuximide.
Sulfinpyrazone Sulfinpyrazone The risk or severity of bleeding can be increased when Trazodone is combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide The risk or severity of hyponatremia can be increased when Trazodone is combined with Chlorothiazide.
Chlorthalidone Chlorthalidone The risk or severity of hyponatremia can be increased when Trazodone is combined with Chlorthalidone.
Metolazone Metolazone The risk or severity of hyponatremia can be increased when Trazodone is combined with Metolazone.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Trazodone.
Secobarbital Secobarbital The risk or severity of adverse effects can be increased when Secobarbital is combined with Trazodone.
Desipramine Desipramine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Desipramine.
Amitriptyline Amitriptyline The risk or severity of QTc prolongation can be increased when Trazodone is combined with Amitriptyline.
Imipramine Imipramine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Imipramine.
Quinidine Quinidine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Quinidine.
Procainamide Procainamide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Procainamide.
Isoniazid Isoniazid The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Isoniazid.
Rifampin Rifampin The serum concentration of Trazodone can be decreased when it is combined with Rifampicin.
Disopyramide Disopyramide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Disopyramide.
Valproic Acid Valproic Acid The risk or severity of QTc prolongation can be increased when Trazodone is combined with Valproic acid.
Tamoxifen Tamoxifen The risk or severity of QTc prolongation can be increased when Trazodone is combined with Tamoxifen.
Butabarbital Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Trazodone.
Levothyroxine Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Trazodone.
Liothyronine Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Trazodone.
Methimazole Methimazole The serum concentration of Trazodone can be increased when it is combined with Methimazole.
Propylthiouracil Propylthiouracil The therapeutic efficacy of Propylthiouracil can be decreased when used in combination with Trazodone.
Dextromethorphan Dextromethorphan The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Dextromethorphan.
Cyclobenzaprine Cyclobenzaprine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Cyclobenzaprine.
Niacin Niacin The metabolism of Trazodone can be decreased when combined with Niacin.
Baclofen Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Trazodone.
Doxylamine Doxylamine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Doxylamine.
Cyproheptadine Cyproheptadine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Cyproheptadine.
Clemastine Clemastine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Clemastine.
Chlorpheniramine Chlorpheniramine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Chlorpheniramine.
Brompheniramine Brompheniramine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Dexbrompheniramine.
Meclizine Meclizine The risk or severity of adverse effects can be increased when Meclizine is combined with Trazodone.
Methyclothiazide Methyclothiazide The risk or severity of hyponatremia can be increased when Trazodone is combined with Methyclothiazide.
Hydrochlorothiazide Hydrochlorothiazide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Hydrochlorothiazide.
Dantrolene Dantrolene The risk or severity of adverse effects can be increased when Dantrolene is combined with Trazodone.
Chlorzoxazone Chlorzoxazone The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Trazodone.
Carisoprodol Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Trazodone.
Methocarbamol Methocarbamol The risk or severity of adverse effects can be increased when Methocarbamol is combined with Trazodone.
Disulfiram Disulfiram The risk or severity of QTc prolongation can be increased when Trazodone is combined with Disulfiram.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The risk or severity of QTc prolongation can be increased when Trazodone is combined with Propranolol.
Minoxidil Minoxidil Trazodone may decrease the antihypertensive activities of Minoxidil.
Pseudoephedrine Pseudoephedrine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Pseudoephedrine.
Nortriptyline Nortriptyline The risk or severity of QTc prolongation can be increased when Trazodone is combined with Nortriptyline.
Nadolol Nadolol The serum concentration of Nadolol can be increased when it is combined with Trazodone.
Butorphanol Injection Butorphanol Injection The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Butorphanol.
Nalbuphine Injection Nalbuphine Injection The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Nalbuphine.
Oxytocin Injection Oxytocin Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Oxytocin.
Trimethobenzamide Trimethobenzamide The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Trazodone.
Flavoxate Flavoxate Trazodone may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
Papaverine Papaverine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Papaverine.
Fluorouracil Injection Fluorouracil Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Fluorouracil.
Acetazolamide Acetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Trazodone.
Calcitonin Salmon Injection Calcitonin Salmon Injection The therapeutic efficacy of Salmon calcitonin can be decreased when used in combination with Trazodone.
Ketoconazole Ketoconazole The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ketoconazole.
Pyrantel Pyrantel The risk or severity of adverse effects can be increased when Pyrantel is combined with Trazodone.
Vincristine Injection Vincristine Injection The serum concentration of Vincristine can be decreased when it is combined with Trazodone.
Captopril Captopril Trazodone may decrease the antihypertensive activities of Captopril.
Dipyridamole Dipyridamole The risk or severity of bleeding can be increased when Trazodone is combined with Dipyridamole.
Isoxsuprine Isoxsuprine The therapeutic efficacy of Isoxsuprine can be decreased when used in combination with Trazodone.
Vinblastine Vinblastine The serum concentration of Trazodone can be decreased when it is combined with Vinblastine.
Metoprolol Metoprolol The metabolism of Metoprolol can be decreased when combined with Trazodone.
Hydroxyzine Hydroxyzine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Hydroxyzine.
Thiothixene Thiothixene The risk or severity of QTc prolongation can be increased when Trazodone is combined with Thiothixene.
Aspirin Aspirin The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Acetylsalicylic acid.
Salsalate Salsalate The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Salsalate.
Alprazolam Alprazolam The risk or severity of adverse effects can be increased when Alprazolam is combined with Trazodone.
Temazepam Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Trazodone.
Triazolam Triazolam The risk or severity of adverse effects can be increased when Trazodone is combined with Triazolam.
Dicyclomine Dicyclomine Trazodone may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
Hyoscyamine Hyoscyamine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Hyoscyamine.
Propantheline Propantheline Trazodone may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
Diltiazem Diltiazem The risk or severity of QTc prolongation can be increased when Trazodone is combined with Diltiazem.
Nifedipine Nifedipine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Nifedipine.
Timolol Timolol The risk or severity of QTc prolongation can be increased when Trazodone is combined with Timolol.
Verapamil Verapamil Verapamil may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Trazodone.
Atenolol Atenolol The serum concentration of Atenolol can be increased when it is combined with Trazodone.
Pindolol Pindolol The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Pindolol.
Diflunisal Diflunisal The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Diflunisal.
Piroxicam Piroxicam The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Piroxicam.
Etoposide Etoposide The serum concentration of Etoposide can be decreased when it is combined with Trazodone.
Glyburide Glyburide The metabolism of Glyburide can be decreased when combined with Trazodone.
Indapamide Indapamide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Indapamide.
Pentoxifylline Pentoxifylline The risk or severity of bleeding can be increased when Trazodone is combined with Pentoxifylline.
Pentamidine Injection Pentamidine Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Pentamidine.
Labetalol Labetalol Labetalol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Trazodone.
Leuprolide Injection Leuprolide Injection The risk or severity of QTc prolongation can be increased when Trazodone is combined with Leuprolide.
Guanabenz Guanabenz The therapeutic efficacy of Guanabenz can be decreased when used in combination with Trazodone.
Ketoprofen Ketoprofen The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Ketoprofen.
Pimozide Pimozide The risk or severity of QTc prolongation can be increased when Trazodone is combined with Pimozide.
Enalapril Enalapril Trazodone may decrease the antihypertensive activities of Enalapril.
Flurbiprofen Flurbiprofen The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Flurbiprofen.
Amiodarone Amiodarone Trazodone may increase the QTc-prolonging activities of Amiodarone.
Buspirone Buspirone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Buspirone.
Lovastatin Lovastatin The metabolism of Trazodone can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ciprofloxacin.
Mesalamine Mesalamine The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Mesalazine.
Diclofenac Diclofenac The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Diclofenac.
Fluoxetine Fluoxetine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Fluoxetine.
Nimodipine Nimodipine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Nimodipine.
Clozapine Clozapine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Clozapine.
Estazolam Estazolam The risk or severity of adverse effects can be increased when Trazodone is combined with Estazolam.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Trazodone.
Ofloxacin Ofloxacin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ofloxacin.
Clarithromycin Clarithromycin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Clarithromycin.
Benazepril Benazepril Trazodone may decrease the antihypertensive activities of Benazepril.
Etodolac Etodolac The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Etodolac.
Felodipine Felodipine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Felodipine.
Fosinopril Fosinopril Trazodone may decrease the antihypertensive activities of Fosinopril.
Nabumetone Nabumetone The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Nabumetone.
Quinapril Quinapril Trazodone may decrease the antihypertensive activities of Quinapril.
Ramipril Ramipril Trazodone may decrease the antihypertensive activities of Ramipril.
Simvastatin Simvastatin The metabolism of Trazodone can be decreased when combined with Simvastatin.
Amlodipine Amlodipine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Amlodipine.
Teniposide Injection Teniposide Injection The metabolism of Trazodone can be decreased when combined with Teniposide.
Itraconazole Itraconazole The risk or severity of QTc prolongation can be increased when Trazodone is combined with Itraconazole.
Lisinopril Lisinopril Trazodone may decrease the antihypertensive activities of Lisinopril.
Oxaprozin Oxaprozin The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Oxaprozin.
Sotalol Sotalol The risk or severity of QTc prolongation can be increased when Trazodone is combined with Sotalol.
Bisoprolol Bisoprolol The serum concentration of Bisoprolol can be increased when it is combined with Trazodone.
Zolpidem Zolpidem Trazodone may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin Doxazosin Doxazosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Trazodone.
Terazosin Terazosin Trazodone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Terazosin.
Isradipine Isradipine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Isradipine.
Omeprazole Omeprazole The metabolism of Trazodone can be decreased when combined with Omeprazole.
Cisapride Cisapride The risk or severity of QTc prolongation can be increased when Trazodone is combined with Cisapride.
Gabapentin Gabapentin The risk or severity of adverse effects can be increased when Gabapentin is combined with Trazodone.
Fluvastatin Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Trazodone.
Venlafaxine Venlafaxine Venlafaxine may increase the serotonergic activities of Trazodone.
Fluvoxamine Fluvoxamine The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Fluvoxamine.
Nefazodone Nefazodone The serum concentration of Nefazodone can be increased when it is combined with Trazodone.
Lamotrigine Lamotrigine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Lamotrigine.
Losartan Losartan The risk or severity of QTc prolongation can be increased when Trazodone is combined with Losartan.
Tramadol Tramadol The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Tramadol.
Vinorelbine Injection Vinorelbine Injection The metabolism of Trazodone can be decreased when combined with Vinorelbine.
Moexipril Moexipril The risk or severity of QTc prolongation can be increased when Trazodone is combined with Moexipril.
Lansoprazole Lansoprazole The metabolism of Trazodone can be decreased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Trazodone.
Nicardipine Nicardipine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Nicardipine.
Bupropion Bupropion The risk or severity of seizure can be increased when Trazodone is combined with Bupropion.
Ticlopidine Ticlopidine The risk or severity of bleeding can be increased when Trazodone is combined with Ticlopidine.
Saquinavir Saquinavir The risk or severity of QTc prolongation can be increased when Trazodone is combined with Saquinavir.
Dalteparin Injection Dalteparin Injection The risk or severity of bleeding can be increased when Trazodone is combined with Dalteparin.
Nisoldipine Nisoldipine The risk or severity of hypotension can be increased when Nisoldipine is combined with Trazodone.
Riluzole Riluzole The risk or severity of adverse effects can be increased when Riluzole is combined with Trazodone.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Gemcitabine can be decreased when it is combined with Trazodone.
Indinavir Indinavir The metabolism of Trazodone can be decreased when combined with Indinavir.
Ritonavir Ritonavir The serum concentration of Ritonavir can be increased when it is combined with Trazodone.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Trazodone.
Clomipramine Clomipramine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Clomipramine.
Mirtazapine Mirtazapine Trazodone may increase the serotonergic activities of Mirtazapine.
Trandolapril Trandolapril Trazodone may decrease the antihypertensive activities of Trandolapril.
Topiramate Topiramate The risk or severity of adverse effects can be increased when Topiramate is combined with Trazodone.
Valsartan Valsartan Trazodone may decrease the antihypertensive activities of Valsartan.
Pramipexole Pramipexole Trazodone may increase the sedative activities of Pramipexole.
Donepezil Donepezil The risk or severity of QTc prolongation can be increased when Trazodone is combined with Donepezil.
Nelfinavir Nelfinavir The risk or severity of QTc prolongation can be increased when Trazodone is combined with Nelfinavir.
Azithromycin Azithromycin The risk or severity of QTc prolongation can be increased when Trazodone is combined with Azithromycin.
Loratadine Loratadine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Loratadine.
Carvedilol Carvedilol Trazodone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Carvedilol.
Flutamide Flutamide The metabolism of Trazodone can be decreased when combined with Flutamide.
Selegiline Selegiline Selegiline may increase the serotonergic activities of Trazodone.
Bicalutamide Bicalutamide The metabolism of Trazodone can be decreased when combined with Bicalutamide.
Sertraline Sertraline The risk or severity of QTc prolongation can be increased when Trazodone is combined with Sertraline.
Propafenone Propafenone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Propafenone.
Irbesartan Irbesartan Trazodone may decrease the antihypertensive activities of Irbesartan.
Tamsulosin Tamsulosin Trazodone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Tamsulosin.
Ropinirole Ropinirole Trazodone may increase the sedative activities of Ropinirole.
Finasteride Finasteride The metabolism of Finasteride can be decreased when combined with Trazodone.
Quetiapine Quetiapine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Quetiapine.
Cetirizine Cetirizine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Cetirizine.
Paroxetine Paroxetine The risk or severity of serotonin syndrome can be increased when Paroxetine is combined with Trazodone.
Tolcapone Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Trazodone.
Citalopram Citalopram The risk or severity of QTc prolongation can be increased when Trazodone is combined with Citalopram.
Efavirenz Efavirenz The risk or severity of QTc prolongation can be increased when Trazodone is combined with Efavirenz.
Sildenafil Sildenafil The metabolism of Trazodone can be decreased when combined with Sildenafil.
Celecoxib Celecoxib The risk or severity of bleeding can be increased when Celecoxib is combined with Trazodone.
Rosiglitazone Rosiglitazone The metabolism of Trazodone can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Tolterodine.
Thalidomide Thalidomide Trazodone may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Balsalazide Balsalazide The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Balsalazide.
Nateglinide Nateglinide The metabolism of Nateglinide can be decreased when combined with Trazodone.
Galantamine Galantamine The risk or severity of QTc prolongation can be increased when Trazodone is combined with Galantamine.
Levetiracetam Levetiracetam The risk or severity of adverse effects can be increased when Trazodone is combined with Levetiracetam.
Rabeprazole Rabeprazole The metabolism of Trazodone can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Trazodone can be decreased when combined with Terbinafine.

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